Chorionic gonadotropin 5000 units for how long. The use of human chorionic gonadotropin for men. Method of use of hCG

Composition and release form

1 bottle of lyophilized powder for the preparation of an injection solution contains 500 or 1000 units of human chorionic gonadotropin, complete with a solvent (isotonic sodium chloride solution 0.9% in 1 ml ampoules); There are 5 sets in a cardboard pack.

Characteristic

White or almost white powder.

pharmachologic effect

pharmachologic effect- gonadotropic.

It has a gonadotropic, predominantly luteinizing effect. In women, promotes ovulation, education and hormonal activity corpus luteum. In men, it stimulates the interstitial cells of the gonads, primarily Leydig cells, thereby enhancing the synthesis of testosterone and partially spermatogenesis, activates the development of the genital organs and secondary sexual characteristics, and in cryptorchidism, promotes the descent of the testicles.

Indications for the drug Chorionic Gonadotropin for injection

Decreased function of the gonads in men and women, caused by disruption of the activity of the hypothalamus and pituitary gland: interstitial pituitary insufficiency (Simmonds disease, Sheehan syndrome, panhypopituitarism of any etiology, adiposogenital dystrophy, pituitary dwarfism with symptoms of sexual infantilism, hypogonadotropic hypogonadism with signs of eunuchoidism), anovulatory dysfunction ovaries and associated infertility, later sexual development, habitual and threatening abortion in the first trimester of pregnancy, dysfunctional uterine bleeding in women of childbearing age, bilateral cryptorchidism in children, unilateral cryptorchidism after surgical treatment in the presence of signs of eunuchoidism, differential diagnosis primary and secondary hypogonadism in men.

Contraindications

Pituitary tumors, inflammatory diseases genital area, hormonally active tumors of the gonads, absence of the gonads (congenital or after surgery), early attack menopause, thrombophlebitis, breastfeeding.

Use during pregnancy and breastfeeding

Breastfeeding should be stopped during treatment.

Side effects

Allergic reactions, headache, depression, enlargement of the testicles located in the inguinal canals, preventing their further descent; premature puberty(with prolonged treatment or use in large doses in male adolescents with impaired physical and sexual development), degeneration of the gonads (with unreasonably long-term use of the drug for cryptorchidism, especially if indicated surgery), atrophy of the seminiferous tubules (due to inhibition of FSH production as a result of stimulation of the production of androgens and estrogens), a decrease in the number of sperm in the ejaculate (with drug abuse in men).

Interaction

Used in combination with menopausal gonadotropin in the treatment of infertility.

Directions for use and doses

IM, in doses of 500-3000 IU/day.

For men - 2-3 times a week, in courses of 4 weeks at intervals of 4-6 weeks. Conduct 3-6 courses over 6-12 months; V diagnostic purposes- 1500-3000 units/day for 5 days.

Women with anovulatory cycles, starting from the 10-12th day of the cycle - 3000 units 2-3 times with an interval of 2-3 days or 1500 units 6-7 times every other day.

For pituitary dwarfism with symptoms of sexual infantilism - 500-1000 units 1-2 times a week for 1-2 months in repeated courses.

For cryptorchidism, children under 10 years old - 500-1000 units, 10-14 years old - 1500 units 2 times a week for 4-6 weeks in repeated courses.

Overdose

Women may experience ovarian hyperstimulation syndrome with an increase in their size.

Precautionary measures

Prescribe with caution to boys puberty, patients with coronary artery disease, arterial hypertension, renal failure, bronchial asthma, migraine.

special instructions

In women, if ovarian hyperstimulation syndrome occurs, the drug should be discontinued.

Storage conditions for the drug Chorionic Gonadotropin for injection

In a place protected from light, at a temperature not exceeding 20 °C.

Keep out of the reach of children.

Shelf life of the drug Chorionic Gonadotropin for injection

4 years.

Do not use after the expiration date stated on the package.

Synonyms of nosological groups

Category ICD-10	Synonyms of diseases according to ICD-10
E23.0 Hypopituitarism	Anovulatory disorders
	Simmonds disease
	Simmonds-Glinsky disease
	Secondary hypogonadism in men
	Secondary hypogonadotropic hypogonadism
	Hypogenitalism
	Hypogonadism
	Hypogonadism hypogonadotropic
	Hypogonadism pituitary
	Hypogonadism in men
	Hypogonadotropic hypogonadism
	Hypopituitrism
	Pituitary infantilism
	Cerebropituitary dwarfism
	Pituitary cachexia
	Diencephalic-pituitary cachexia
	Larona dwarfism
	Pituitary insufficiency
	Growth retardation in children with hypopituitarism
	Panhypopituitarism
	Primary hypogonadism
	Primary hypogonadotropic hypogonadism
	Kallmann syndrome
	Fertile eunuch syndrome
	Schehen's syndrome
	Sheehan syndrome
	Sheehan syndrome
E23.6.0* Adiposogenital syndrome	Adiposogenital dystrophy
E23.6.0* Adiposogenital syndrome	Adiposogenital syndrome
E23.7 Disease of the pituitary gland, unspecified
	Diagnosis of disorders of gonadotropic function of the pituitary gland
	Interpituitary insufficiency
	Pituitary gland dysfunction
	Insufficiency of the anterior lobe of the pituitary gland
	Cerebrohypophyseal disease
E25 Adrenogenital disorders	Adrenogenital syndrome
	Congenital dysfunction of the adrenal cortex
	Macrogenitosomia in boys
	Apert-Halle syndrome
	Crook-Aper-Halle syndrome

E28 Ovarian dysfunction	Dysfunction of the gonads
	Ovarian dysfunction
	Non-functioning ovaries

	Decreased function of the gonads
	Estrogen deficiency
E28.3 Primary ovarian failure	Ovarian hypogonadism (primary)
	Ovarian hypofunction
	Estrogen deficiency
	Insufficient estrogen content in the body
	Estrogen deficiency
	Estrogen deficiency
	Primary ovarian dysfunction
	Estrogen deficiency conditions
E29 Testicular dysfunction
	Androgenic dysfunction
	Dysfunction of the gonads
	Dysfunction of the gonads in men
	Underdevelopment of the genital organs in men
	Primary hypogonadism in men
E29.1 Testicular hypofunction	Androgen deficiency
	Androgen deficiency
	Leydig cell aplasia
	Testicular hypogonadism (primary)
	Testicular hypoplasia
	Hypofunction of the gonads in men
	Eunuchoidism
	Androgen deficiency
	Androgen deficiency in men
	Leydig cell deficiency
	Testosterone deficiency
	Reduced function of the gonads
E30.0 Delayed puberty	Late puberty
E30.0 Delayed puberty	Puberty late
E34.3 Short stature [dwarfism], not elsewhere classified	Pituitary dwarfism
	Pituitary dwarfism
	Stunting
	Stunted growth in children
	Dwarfism
	Pituitary dwarfism
	Nanism is disproportionate
	Nanism associated with external factors
	Disruption of the growth process
	Growth disorder
	Impaired endogenous hormone secretion with growth retardation
	Growth disorders
	Growth hormone deficiency
	Endogenous growth hormone deficiency
	Stunting
N94.6 Dysmenorrhea, unspecified	Algomenorrhea
	Algomenorrhea
	Pain syndrome due to smooth muscle spasms
	Pain syndrome due to smooth muscle spasms (renal and biliary colic, intestinal spasms, dysmenorrhea)
	Pain syndrome due to smooth muscle spasms internal organs
	Pain syndrome due to spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasms, dysmenorrhea)
	Pain during menstruation
	Painful, irregular periods
	Pain during menstruation
	Pain during menstruation
	Dysalgomenorrhea
	Dysmenorrhea
	Dysmenorrhea (essential) (exfoliative)
	Menstrual disorder
	Menstrual crumpies
	Menstruation is painful
	Metrorrhagia
	Violation menstrual cycle
	Menstrual irregularities
	Primary dysalgomenorrhea
	Prolactin-dependent menstrual disorder
	Prolactin-dependent menstrual dysfunction
	Menstrual disorder
	Spasmodic dysmenorrhea
	Functional disorders of the menstrual cycle
	Functional disorders of the menstrual cycle
N97 Female infertility	Anovulatory infertility
	Female infertility
	Infertility due to hyperprolactinemia
	Infertility of ovarian origin
	Infertility caused by hypothalamic-pituitary dysfunction
	The marriage is barren
	Hyperprolactinemic infertility
	Hyperprolactinemia with infertility
	Female infertility due to anovulation
	Stimulation of growth of one follicle
	Functional infertility
	Endocrine infertility
O20.0 Threatened abortion	Abortion is threatening
	Miscarriage is threatening
	Spastic condition with risk of abortion
	Threatened abortion
	Threatened miscarriage in the first trimester of pregnancy
	Threatened spontaneous miscarriage
	Threat of miscarriage
	Threat of spontaneous miscarriage

HCG (human chorionic gonadotropin) is a hormone that large quantities produced by the chorion of the embryo. This happens within a week after fertilization. A sufficient amount of it indicates a normally developing pregnancy. Chorionic gonadotropin is also present in small amounts in the body of men and women who are not expecting a child. A drug containing this hormone is widely used in medicine for various purposes.

What is human chorionic gonadotropin and what is it responsible for? This substance belongs to gonadotropic hormones. It plays an important role in the body of men and women. This substance is on a par with follicle-stimulating hormones, but differs from them in structure. Human chorionic gonadotropin is a complex protein base in which carbohydrate elements are present. It consists largely of amino acids.

Chorionic gonadotropin, produced in large quantities in the body of a pregnant woman, is excreted unchanged from her body in the urine. From there it is extracted to create medicines that are subsequently used for various purposes.

Pharmacological properties of gonadotropin

A drug containing gonadotropin hormone has the following pharmacological properties:

promotes the synthesis of sex hormones in the female body, which occurs in the ovaries. In men, the same process occurs in the testicles. Human chorionic gonadotropin especially affects testosterone production;
promotes ovulation;
stimulates spermatogenesis in men;
provides normal functioning corpus luteum, which is especially important during pregnancy;
affects normal development genital organs in men and women, provokes the appearance of secondary sexual characteristics.

Indications for use of the drug gonadotropin

The peculiarity of the use of gonadotropin is that it can eliminate many problems that are found in men and women. This drug is most often used to treat decreased sexual function, which occurs when normal operation pituitary gland and hypothalamus.

The most common indications for use of this medicine are considered:

Simmonds syndrome, which causes serious hormonal disorders of various kinds;
necrosis of the pituitary gland observed after childbirth. This condition is a complication that occurs as a result of significant bleeding;
different types, regardless of the reasons for its occurrence;

adiposogenital dystrophy with emerging obesity, which is localized in the area of the brain where the hypothalamus and pituitary gland are located;
caused by insufficient function of the pituitary gland, which is accompanied by sexual disorders;
, accompanied by sexual dysfunction, absence of normally developed genitals;
infertility in women, which is associated with lack of ovulation;

with delayed sexual development in men and women;
when there are threats of spontaneous abortion in the first trimester of pregnancy in the presence of a fetus that is developing normally;
uterine bleeding in women of reproductive age;
to stimulate the descent of the testicles into the scrotum in children;
Diagnosis of hypogonadism in representatives of the stronger sex.

Use of gonadotropin drug in sports

Chorionic gonadotropin has anabolic properties. It is because of this that they began to use it in bodybuilding for gaining muscle mass. Also, a drug containing this hormone has a special effect, which stimulates the reduction of body fat. The human body begins to consume more intensively energy reserves, which is why the weight loss effect occurs. At the same time, the muscles do not undergo splitting, as can be observed in a natural process without external intervention.

Recent research by scientists indicates that the use this drug may be hazardous to human health. Chorionic gonadotropin produces a much smaller effect on gaining muscle mass than taking other anabolic steroids. To get a noticeable result, it is necessary to administer large doses of the drug, which negatively affects the functioning of the body.

Gonadotropin for men is indicated exclusively in cases where there is high risk testicular atrophy due to the use of anabolic steroids. In this case, it is recommended to use the drugs in minimum dosage, which eliminates negative consequences for the body. They are taken after a long course of steroids (more than 1-2 months). At this time it is also recommended to consume vitamin complexes and lots of protein foods.

Method of use of the gonadotropin drug

Human chorionic gonadotropin is released pharmaceutical companies in the form of a powder, which is intended for preparing a solution. For this purpose, a solvent (most often sodium chloride) is included in the kit for the main drug. It must be introduced into an ampoule with powder, and then used for its intended purpose. The drug usually dissolves well within a few seconds. The resulting liquid is injected intramuscularly.

If the prepared solution is not completely used, then it must be moved to the refrigerator. Dry powder should be kept in a dark place out of reach of children. The optimal temperature for this is no more than 20°C.

Half-life active substances of the drug is several hours. The results from using one injection are preserved long time– about 5-6 days.

Acceptable dosages of gonadotropin

Instructions for use of this drug indicate the optimal dosage:

for women in the absence of ovulation, to stimulate this process with one injection - from 5,000 to 10,000 units;
stimulation normal life corpus luteum - maximum dose 5000 units (used on certain days of the menstrual cycle);
during the IVF procedure during stimulation of ovulation - 10,000 U in one injection;
in case of recurrent miscarriage (before 8 weeks of pregnancy), the entire first trimester - the first dose is 10,000 units, then 5,000 units 2 times a week;
for developmental delays in children (boys) - a maximum dose of 5000 IU for 3 months or more once a week;
in case of violation reproductive function for men - maximum dose of 2000 units 2-3 times a week for several months;
during treatment hypogonadotropic hypogonadism– maximum dose 6000 U once a week;
to assess testicular function when diagnosing certain conditions – 5000 U once;
for testicular descent in boys under 6 years of age - maximum dose of 1000 U 2 times a week for 1.5 months;
for the descent of the testicles in boys over 6 years old - 1500 units twice a week for 1.5 months;
for oligospermia - 5000 units every week for 3 months.

Contraindications for use

Human chorionic gonadotropin is not used with therapeutic purpose in the following cases:

ovarian cancer;
hypersensitivity to any component;
absence of glands reproductive system (congenital pathology, the result of the operation);
hypothyroidism;
menopause that came too early;
tumors of various types (pituitary gland or hormonally dependent gonads);
thrombophlebitis;
lactation;
adrenal dysfunction;
obstruction of the uterine tubes.

Also, with great caution, this drug is prescribed for hypertension, in adolescence, for the treatment of people with kidney failure, asthma or frequent migraine episodes.

Side effects of gonadotropin

Chorionic gonadotropin 1500 IU dosage or any other can provoke the following adverse reactions:

increased irritability;
pain at the injection site;
hyperemia;
allergic reactions of various manifestations;
headache;
high fatigue;
depressive states;
inhibition of the normal functioning of the pituitary gland;
in women, when taken in large doses, ovarian hyperstimulation syndrome is observed, in men - tissue swelling, nipple sensitivity, enlarged testicles;
with long-term use in men, suppression of sperm activity is observed.

Reception features

With increasing doses of the drug, women often experience ovarian hyperstimulation syndrome, which is accompanied by an increase in their size.

This dangerous condition, requiring symptomatic treatment. Main complications this state– ascites and hydrothorax. In the treatment of infertility, this drug is often used in combination with menopausal gonadotropin.

When treating men, the drug has been proven to be ineffective at high concentrations of FSH. Unfounded long-term use means leads to negative consequences. When treating children, premature puberty may occur. If the hormone is administered for cryptorchidism, degeneration of the genital organs sometimes occurs.

Long-term use may cause the formation of specific antibodies. This is a dangerous condition that leads to a decrease in hormone concentration immune system. During pregnancy, this leads to miscarriage or premature birth. If this drug was used to stimulate ovulation, the likelihood of producing two or more eggs increases several times.

It should also be taken into account that after discontinuation of the drug, in both men and women, a pregnancy test will show a false positive result for a week.

Manufacturers

Chorionic gonadotropin is produced by several pharmaceutical companies under different trade names:

Moscow endocrine plant. It has generic name, denoting the active substance;
Rotten. Contains human chorionic gonadotropin 500, 100, 1500, 3000 units in one bottle. Manufacturer – Netherlands;
Profasi. Manufacturer – Switzerland;
Ovitrel. Manufacturer – Italy.

The descriptions of these drugs are identical. They have the same range of applications and side effects. The tablet is not used as a medicinal component. All products are ready-made or semi-ready solution for injection.

Bibliography

Atlas by ultrasound diagnostics in obstetrics and gynecology. Dubile P., Benson K.B. 2009 Publisher: MEDpress-inform.
Metabolic syndrome and thrombophilia in obstetrics and gynecology. Makatsaria A.D., Pshenichnikova E.B. 2006 Publisher: MIA.
Arterial hypertension in pregnant women Preeclampsia (preeclampsia). Makarov O.V., Volkova E.V. RASPM; Moscow; TsKMS GOU VPO RGMU.-31 pp.- 2010.
Herpes infection, antiphospholipid syndrome and fetal loss syndrome. HELL. Makatsaria, N.V. Dolgushina, 2008, Moscow, “Triad-X”.
Obstetric risk. Maximum information - minimum danger for mother and baby Radzinsky V.E., Knyazev S.A., Kostin I.N. 2009 Publisher: Eksmo.

Most often, gonadotropin is used in sports and bodybuilding, but its application is much more extensive. For athletes, it helps produce more testosterone and has an anabolic effect; for women, hCG therapy is sometimes required not only during pregnancy, but also before it. Restoring the menstrual cycle, improving the functioning of the corpus luteum, stimulating follicles- all this requires use this tool. How to take gonadotropin in all these cases so as not to harm yourself?

Dosage and regimen of hCG

Gonadotropin in tablets is not used because it has low effectiveness, so it is administered by injection into the muscle. Here it is absorbed faster, which means it begins to work more actively. You can give injections yourself, but only if you have the necessary skills so as not to damage other important areas near the muscle.

The dosage of the drug is selected in each case purely individually. Pharmacies usually provide gonadotropin in doses from 500 IU to 10,000 IU, which allows you to immediately dilute the required amount of medication with one injection.

The standard dosages of gonadotropin used will be given below, but it should be used only as prescribed by a doctor. We must not forget that incorrect treatment This medicine can cause many problems, as well as delay the treatment of the underlying disease. So, standard dosages for various pathologies, as a rule, the following:

When stimulating the corpus luteum, it is enough to use hCG in an amount of 1500 IU per day of ovulation (that is, on the third, sixth and ninth day), or inject 5000 IU at a time.
If there is a threat of miscarriage, 10,000 IU is first prescribed, then therapy is continued weekly at 5,000 IU twice. The period of application is strictly limited. Treatment should begin and end from 8 to 14 weeks of pregnancy, respectively.
Gonadotropin injections are also given to maintain pregnancy if a woman has previously experienced recurrent miscarriage. Dosage in in this case similar to those prescribed for threatened miscarriage.
Stimulation of follicular growth precedes further reproductive activities. In the latter case, a one-time injection of 10,000 IU of gonadotropin is sufficient so that after 34 hours a mature egg can be selected.
In cases of developmental delay, hCG is prescribed in an amount of 3000-5000 IU for 3 months every week. This dosage is suitable for teenagers; for men, hCG 500, 1500 or 2000 IU is more often used 2-3 times a week. The course of therapy is selected individually and can last 1.5-3 months.
Hypogonadotropic hypogonadism is treated in combination with menotropins. 1500-6000 IU of gonadotropin are administered at a time.
Up to 6 years of age, boys with cryptorchidism are injected with either 500 IU twice a week, or 1000 IU at a time for 6 weeks. After 6 years, the dosage of gonadotropin increases and will be 1500 IU, and the medicine must be administered twice a week.

Rules for gonadotropin injection

HCG is sold in pharmacies, usually in the form of a powder for injection, which is then diluted either with a special solution or with water for injection. Dilution of the drug at home is done as follows:

Remove the rubber protective cap without opening the bottle;
Wipe it with alcohol;
Fill a clean syringe with water for injection (2 ml) and, without removing the cap from the bottle, pierce it with a needle and slowly inject the liquid into it;
The diluted medicine should not be shaken, exposed to the sun, or heated in any way;
Draw the solution into the cavity without removing the syringe and inject.

A gonadotropin injection is given in the same way as any other intramuscular injection. The safest area is gluteal muscle, and not all of it, but only its upper part. In order not to hurt sciatic nerve, mentally draw a cross on your buttock.

The upper outer part of the thigh is best place for independent intramuscular injection. Naturally, both before and after the procedure it is necessary to treat the area with alcohol.

The storage of the medicine must also be approached correctly so that it does not spoil. So, human chorionic gonadotropin should be stored in the refrigerator (not in the freezer!), especially if it has already been diluted. You can choose another cool place for it, the main thing is that the temperature is no higher than 10-12 degrees.

The hCG injection is designed to compensate for the amount of human chorionic gonadotropin in the body when its natural production is insufficient. An injection involves the administration of one of the drugs that have different commercial names. The list of such drugs includes: human chorionic gonadotropin (Russia), Profazi (Switzerland), Pregnil (Netherlands or USA), Horagon (Germany), etc. The main purpose of such drugs is to affect hormonal background body and restoration of the functions of the genital organs. The need to inject hCG into women wishing to become pregnant is explained by the normalization of the ovulatory process and the occurrence of subsequent hormonal activity of the corpus luteum after the injection.

Chorionic gonadotropin: general information

HCG or human chorionic gonadotropin has two subunits in its structure: alpha and beta. The alpha subunit is identical in structure to the TSH, FSH, and LH subunits. The beta subunit has no analogues. It is the basis for tests that determine pregnancy.

The production of the beta component of hCG occurs in the first weeks of pregnancy. And by the 11th week its content increases thousands of times. After this, its level begins to gradually fall. For this reason, it is important to monitor human chorionic gonadotropin during the perinatal period. Thus, monitoring the level of the hormone allows you to timely determine its decrease or increase, which may indicate the development of certain pregnancy pathologies (threat of miscarriage, ectopic pregnancy and etc.).

In addition, a woman registered for infertility must undergo testing to detect antibodies to hCG. These antibodies do not allow the protein to fully function, which leads to a decrease in placental lacogen, estradiol, and progesterone. Due to human chorionic gonadotropin, embryo rejection and its death inside the mother's womb are excluded. This is another argument in favor of monitoring its level. Patients who have antibodies to hCG in their blood are recommended to undergo plasmapheresis and take advantage of the possibilities of in vitro fertilization.

Usually, human chorionic gonadotropin levels are monitored during pregnancy, which is normal in such a situation. However, a beta-hCG test may in some cases be indicated for some non-pregnant women and even men. A test that detects human chorionic gonadotropin in the blood is prescribed to men and non-pregnant women when it is necessary to confirm hormone-producing tumors.

For injections, human chorionic gonadotropin is produced in the form of a solution or in the form of a lyophilisate (a solution is prepared from it). This protein is extracted for production hormonal drugs from the urine of pregnant women.

Indications for the use of hCG injections

The effectiveness of drugs with hCG has been noted when the following conditions occur in women:

dysmenorrhea;
ovarian dysfunction;
anovulatory infertility;
corpus luteum deficiency;
threat of spontaneous miscarriage;
inability to bear fruit;
preparation for IVF;
formation of the placenta.

The drug with hCG can act as additional means with assisted reproductive techniques.

Recombinant hCG has the following effects:

on the ovaries and tissues to enhance the production of sex hormones;
when stimulating ovulation.

Instructions for using hg

The drugs are injected intramuscularly. It is permissible for a woman to inject herself with hCG, but only if she knows how to do it intramuscular injections. Otherwise, she will have to look for a person from her inner circle who could do this for her. If none of the options is possible, then you can go for injections in treatment room that antenatal clinic, which the patient visits at her place of registration. But this option is not entirely convenient, since the injections are prescribed for a long time, in entire courses, and the opportunity to visit the treatment room of the clinic is not always possible. Therefore, it is best to find a person who can come to your home or do it yourself.

When stimulating ovulation, the doctor will recommend an injection of hCG into the stomach. This is much more painless and convenient than placing it in the buttock. To do this, measure a distance of about two fingers from the navel to the left and right. Having pinched the skin fold, insert the needle into it completely. For these purposes, it is better to select a short insulin needle. The injection site must be treated with a cotton swab soaked in an alcohol solution.

Permissible doses of drugs with hCG.

The volumes of human chorionic gonadotropin may vary. The following dosages of the hormone are available in the pharmacy chain: 500 units, 1000 units, 1500 units, 5000 units, 10000 units.

Dosages at different problems An obstetrician-gynecologist may prescribe the following.

The dosage of human chorionic gonadotropin injections, which are prescribed to maintain pregnancy, can range from 5,000 IU to 10,000 IU. Each time it will depend on how much of the hormone is detected in the pregnant woman’s blood. In addition, the size of the follicle is taken into account, since ovarian hyperstimulation syndrome may develop due to an injection of a drug with hCG.

One of the main indications for the use of hCG injections is infertility. After ovulation stimulation, several procedures are prescribed ultrasound examination. During ultrasound sessions, follicle growth is monitored (up to 20-25 cm) and then hCG is injected, which triggers the ovulation mechanism. Also, the action of the hormone is directed against the regression of follicles, that is, it prevents the development follicular cyst. In order to stimulate ovulation, human chorionic gonadotropin is indicated once in a dose of 5000 or 10000 units. The effect of the administered injection is assessed after 24-36 hours using ultrasound equipment. Performing injections with hCG increases the possibility of conception many times over.

To stimulate the performance of the corpus luteum for 3-6-9 days, human chorionic gonadotropin is indicated at a dose of 1500 units or hCG 5000 units.

When performing superovulation as part of reproductive measures, the patient, after stimulating the growth of several follicles, is injected once with about 10,000 units of human chorionic gonadotropin. The egg is collected 34-36 hours after the hCG injection.

If a threat of miscarriage is suspected, 10,000 units of the drug are first administered, after which the dose is reduced to 5,000 units, which is administered twice a week. Therapy begins before the 8th week of gestation and can be continued until the 14th week.

Indications for hCG injections for pregnant women.

Pregnant women are prescribed injections with hCG when there is a sharp drop in the level of human chorionic gonadotropin in the blood in order to maintain pregnancy in the future. Low concentration this complex protein in the blood may explain early diagnosis. Before prescribing hormone therapy to a pregnant woman, the doctor will once again send for a test to confirm the lack of gonadotropin.

In situations in which deviations of the indicator are significant from normal value, always taken into account for the week of pregnancy, and this downward deviation is more than 20%, then a course of hormone therapy is prescribed in mandatory. Such a deviation in the hormone level may be evidence of abnormalities, such as:

ectopic pregnancy;
frozen pregnancy;
chronic placental insufficiency;
threat of miscarriage.

Side effects of hCG injection

Side effects in women: due to the administration of the drug, ovarian hyperstimulation syndrome, hydrothorax, ascites, thromboembolism, and cysts may occur.

Other side effects from hCG are rare. This may be discomfort and sensation nagging pain in the stomach, flatulence (gas in the stomach), mood swings, excessive restlessness and fatigue. After completing the course of treatment, such symptoms usually disappear.

List of contraindications.

Measures involving the artificial administration of a hormone-containing drug are contraindicated:

during lactation;
at the onset of early menopause;
at tumor process in the pituitary gland and ovaries;
with thrombophlebitis;
When fallopian tubes declared impassable;
when allergic reactions on the drug;
for diseases of the adrenal glands;
with hyperthyroidism.

If there are difficulties with conceiving or carrying an embryo, the doctor will first identify the cause of this disorder by prescribing a hCG test and a number of other examinations. Despite the importance of human chorionic gonadotropin for the processes of ovulation and for maintaining the development of the fetus, as well as when its deficiency is identified and for some other indications, the doctor prescribes hCG injections to artificially restore the lost balance of the amount of hormone in the woman’s body.

However, you should not worry that this hCG injection will be dangerous to the health of the woman herself or to the fetus.

In most situations, it is thanks to this measure that expectant mother It is possible to preserve and bear a healthy baby. The sooner a disorder requiring immediate attention is identified medical care, the higher the chances of a positive outcome.

Almost every woman who plans to get pregnant knows what hCG is. This one is after the egg is fertilized. However, this does not happen with anovulation. That is, problems arise with the further occurrence, maintenance and development of pregnancy.

An injection of hCG to stimulate ovulation is used after the doctor detects a dominant follicle. The injection allows him to grow to required sizes and burst.

What is a hormone?

Chorionic gonadotropin (hCG) is specific hormone human, which contains subunits such as alpha and . The second has no analogues in the body, so pregnancy tests are made on its basis. It is produced in the first weeks of embryo development. Its number is growing significantly. However, from the 11th week, the concentration of the hormone may decrease.

During this period, it is necessary to monitor the peculiarities of the course of pregnancy. Jumps in hCG levels may indicate pathologies of fetal development and the threat of miscarriage. If the amount of the hormone is insufficient, then the woman has an abortion or its onset becomes impossible.

HCG promotes the production of progesterone and estrogen. The formation of the corpus luteum depends on these hormones, proper development and attachment of the embryo to the lining of the uterus. It is he who ensures the preservation of pregnancy even before the formation of the placenta.

Indications and contraindications for use of the product

HCG drugs have a luteinizing gonadotropic effect. They stimulate the onset of ovulation in women. They should be used if the patient has:

dysfunction of the gonads, provoked by improper functioning of the pituitary gland and hypothalamus;
anovulatory infertility (that is, lack of education dominant follicle and development of the egg);
insufficient functionality of the corpus luteum;
recurrent miscarriage;
dysmenorrhea.

HCG injections are required for the normal formation of the placenta in a pregnant woman. Without drugs based on gonadotropins, it is impossible to stimulate ovulation and IVF.

But it is not always possible to use hCG-based medicine. Contraindications include:

hypersensitivity to the components of the product;
early menopause;
congenital or postoperative absence of the gonads;
neoplasm in the pituitary gland;
hormonally active tumors.

And also you should not give hCG injections in the presence of thrombophlebitis, hypothyroidism, insufficiency of adrenal gland functionality, obstruction fallopian tubes, ovarian cancer and during breastfeeding. The medicine must be used very carefully when renal failure, bronchial asthma, migraines, pressure surges, cardiac ischemia, and also in adolescence.

Rules of application

Before you begin the procedure for administering hCG, you need to make sure that it is approved. It is important to follow these rules:

Check the degree of patency of the fallopian tubes. If there is a problem, then there is no point in carrying out the procedure. Patency can be determined using laparoscopy or other diagnostic methods.
Determine hormonal balance. Tests are taken on the 3rd day of the menstrual cycle. Based on the results, the dosage of stimulant medications can be adjusted.
Perform an ultrasound. This procedure will have to be carried out many times. It is imperative to determine a woman’s ovarian reserve.
Take a spermogram for your partner, as well as test the compatibility of the couple to conceive a child.

HCG injection 5000 units. most often used if a woman does not ovulate for some reason. In most cases, this dose is enough to start the process. It must be done intramuscularly. A woman can give an injection on her own if she knows how to do it. If this is not possible, then it is better to entrust the procedure to a specialist.

If an injection of hCG is to help stimulate ovulation, then it should be done in the abdomen. This method is faster and more convenient. In addition, an injection in the buttock is characterized by the fact that its pain is more pronounced.

The distance from the navel to the injection site is about 2 cm on the left and right side. Next, you need to pinch the fold of skin and insert the needle into it all the way to the base. It should be short (preferably insulin). The hCG injection site must be disinfected.

In case of stimulation of ovulation, monitoring using ultrasound is indispensable. It is important to monitor the size of the dominant follicle. As soon as they are as acceptable as possible, an hCG injection is immediately given. It is he who starts the ovulation process. Regression of the follicles is prevented, so the development of cysts is prevented.

One injection is enough to stimulate ovulation. The effectiveness of the procedure is checked by ultrasound on the second or third day. It significantly increases the chance of getting pregnant.

Before stimulation, it is necessary to check the woman’s hormonal levels. Sometimes, to restore her menstrual cycle, it is enough for her to undergo a simple course of treatment without the use of hCG.

Features of the stimulation process

Any interference with natural processes female body, does not pass without a trace. All procedures with hormones must be carried out with the permission and under the supervision of doctors. Before prescribing an hCG injection, the specialist must find out the following data:

dynamics of follicle enlargement;
features of endometrial growth.

And he is also obliged to predict when ovulation should occur. In addition to the injection, the patient may be prescribed concomitant medications: Puregon or Clostilbegit. After the injection, ovulation occurs no later than 36 hours. The following drugs are suitable for injection: Pregnil, Chorionic Gonadotropin. The dosage of the drug is prescribed by the doctor. The most commonly used injection of hCG is 10,000 units.

During this period, it is necessary to have regular sexual intercourse with a partner in order to become pregnant. You should have sex every other day. Next, there is additional stimulation of the functionality of the corpus luteum, which initially ensures the success of pregnancy and embryo development.

How to choose the right dosage?

This question should be addressed to a doctor who has examined the patient and is familiar with the instructions for use. You should not use injections on your own. For the first time, 5000 units of hCG are usually prescribed. If this dosage does not give positive effect, then it can be increased to 10,000 units, but in the next cycle.

If ovulation has occurred, which was confirmed by ultrasound, then the patient is indicated for additional stimulation of the functionality of the corpus luteum. is prescribed on days 3, 6 and 9 after the release of the egg. The dosage in this case is minimal - no more than 5000 units.

In the presence of recurrent miscarriage pregnancy, the course of treatment using hCG is long - up to 14 weeks. The first dose of the drug is 10,000 units. Further, the rate decreases. A woman receives 2 injections per week, 5000 units each.

Possible side effects

After stimulation has been carried out, it is important to ensure that ovulation occurs. Sometimes the patient may experience ovarian hyperstimulation syndrome. The follicle simply cannot rupture and develops into a cyst. In addition, the administration of hCG can cause other side effects:

gastrointestinal disorders (diarrhea, constipation, nausea);
thromboembolism (blockage of blood vessels by a detached blood clot);
hydrothorax (fluid accumulation in pleural cavity, which is non-infectious);
gynecomastia (this symptom is typical for men and manifests itself in enlarged mammary glands);
increased sensitivity of the nipples.

The patient may also experience painful sensations, as well as a rash in the area of hCG injection. There is also discomfort in the mammary glands and fever. However, after cessation of stimulation, all discomfort disappear.

Overdose and special instructions for the use of hCG

An overdose of hCG may be accompanied by ovarian hyperstimulation syndrome, which negatively affects general health women. That is, the patient develops an excessive number of follicles, which over time degenerate into cysts. Treatment of all side effects is symptomatic.

It is important to remember that long-term use of hCG-based drugs is fraught with the formation. The likelihood of multiple embryos increases (development of multiple pregnancy). During treatment, as well as for a week after its completion, pregnancy tests may show an erroneous result.

If there have already been several unsuccessful attempts at stimulation, in which the dosage of the drugs used was gradually increased, then it is necessary to stop the process and undergo additional tests. After this, treatment methods are reviewed.

If the drug Clostilbegit is used for stimulation, it is recommended to use it no more than 5-6 times throughout life. Otherwise, ovarian wasting syndrome will occur and the woman will not be able to use her own eggs even for artificial insemination.

If stimulation does not give the expected result and pregnancy does not occur, do not give up. Perhaps the long-awaited conception will occur after 2-3 months naturally. Moreover, now there are new reproductive technologies that allow a woman to become a mother.