Pregnancy is one of the most wonderful periods in the life of every woman. Unfortunately, not all women experience these wonderful 9 months without health problems. And all because the body is as weakened as possible, the immune system cannot always overcome the offensive various infections and diseases. In such situations, there is no way to do without antibiotics, because even the most minor infection can harm the baby. One of the most effective antibiotics, Cefazolin, consisting of synthetic substances, has a wide spectrum of action.
Cefazolin is a first generation antibiotic. This drug can not only prevent the proliferation of bacteria in the body, but also destroy microorganisms.
The antibiotic has 2 names:
- Cefazolin.
- Cefazolin Akos.
The only difference between these drugs is that they have different manufacturers, but all other properties are absolutely the same.
Cefazolin is available exclusively in powder form for intravenous or intramuscular injection. The medication is dissolved in water, glucose or sodium chloride. Maximum concentration Cefazolin appears in the blood within an hour. Complete cleansing of the drug from the body occurs after 24 hours.
The drug is able to penetrate into all organs human body However, the entry of Cefazolin into the brain will be minimized, because passage through the blood-brain barrier is as difficult as possible. Reception medical product during pregnancy can be harmful, because its components are able to penetrate the placenta, which carries a risk of exposure harmful substances into the fetus and amniotic fluid.
Indications for the use of Cefazolin during pregnancy
There are several ailments for which a doctor can prescribe Cefazolin:
- Various lung diseases.
- Inflammation in the heart area.
- Infections that enter the body through the blood.
- Diseases abdominal cavity.
- Infection associated with a burn or recent surgery.
- Venereal diseases.
- Inflammation in the pelvic area.
- Inflammation of bones and joints, accompanied by infection.
All of the above possible problems in the body of a pregnant woman may serve as an indication for the use of Cefazolin.
Contraindications to the use of Cefazolin during pregnancy
Before using an antibiotic, it is necessary to take into account that it has a number of contraindications. Failure to comply with all regulations for the use of the drug can lead to irreversible consequences.
- Allergic reaction to the components of the drug.
- Tendency to anorexia.
- Gospel disease.
- Reduced hemoglobin.
- Increased level of sugar in urine.
- Kidney dysfunction.
- Disturbed acid-base balance.
- Dysbacteriosis.
- Any form of stomatitis.
- Sudden drop in white blood cell count.
- Negative consequences after intravenous injection.
- Significant increase in platelets.
- Pain in the lower abdomen.
- The presence of any type of fungus.
- Nausea and vomiting.
If any of the above contraindications are present, the medication should be replaced with a more suitable one.
Side effects when using Cefazolin during pregnancy
Like almost any drug, Cefazolin has its own adverse reactions, which you also need to know before taking the drug:
- nausea and vomiting;
- heartburn;
- diarrhea;
- hives;
- Quincke's edema;
- anemia;
- kidney dysfunction;
- painful sensations at the injection site;
- convulsions;
- dizziness.
Use of Cefazolin during pregnancy
Cefazolin is an antibiotic that is strictly prohibited to be taken without permission during pregnancy, without consulting a specialist. This drug is prescribed, as a rule, in cases where it is not possible to immediately determine the type of disease.
The use of the drug in the 1st trimester of pregnancy cannot be considered safe, since during this period all vital important organs and systems in the baby’s body.
Cefazolin injections during pregnancy - 2nd trimester
The prescription of Cefazolin in the second trimester is allowed only if there is an emergency. If possible, you should avoid taking an antibiotic during pregnancy or choose a more gentle one.
Cefazolin injections during pregnancy - 3rd trimester
3rd trimester is not less safe period gestation of the fetus. Despite the fact that there are only a few days left until the long-awaited meeting with the baby, the risk of irreversible consequences does not decrease.
If urgent treatment is necessary, a qualified specialist is obliged to select a more gentle dosage that will cause minimal harm to the fetus.
3 factors that a doctor should consider when prescribing Cefazolin:
- indication for caesarean section;
- complications during pregnancy due to chronic diseases;
- treatment with the drug for no more than three days.
Use of Cefazolin during pregnancy - instructions for use
As mentioned above, the use of Cefazolin on early stages pregnancy can significantly harm a small developing organism.
Cefazolin Akos injections are more or less safe in the second and third trimester of pregnancy, however, without emergency It is still not worth using the drug. The medication must be prescribed by a strictly qualified specialist. Its use must correspond to the doctor’s prescription; an independent reduction or increase in the dosage of the drug will reduce it medicinal properties to zero and will worsen the patient’s condition.
Before starting intramuscular injection, it is necessary to dilute 0.5 g. powder in 3 ml of a special liquid intended for injection, and for the intravenous proportion the volume is increased to 10 ml.
In order to administer a medication using a dropper, about 200 ml of isotonic sodium chloride is needed. Maximum daily dosage drug – 12 g. The duration of treatment with Cefazolin ranges from 7 days to 2 weeks. As a rule, the drug is used no more than 4 times a day. More precise prescriptions will be given by the attending physician, depending on the condition and degree of the patient’s disease.
In the presence of diseases associated with the respiratory system and genitourinary system, the specialist prescribes the administration of Cefazolin no more than twice a day, 0.5 g. If complications occur, the dose is increased.
For sepsis and peritonitis, the doctor prescribes 3 grams. medication no more than 4 times a day.
Using the drug in a higher dosage and for longer than two weeks can cause infections and microflora disorders in a woman’s body.
The medication should be stored in a dark, cool place. The shelf life of the drug is 3 years.
How to replace Cefazolin during pregnancy
Exists great amount analogues of Cefazolin, which have the same properties:
- Cesolin.
- Natsef.
- Kefzol.
- Anceph.
- Cephalexin.
- Cefadroxil.
The only difference from Cefazolin is that they are available in tablet form. They are also strictly prohibited from being used without permission, without the advice of a qualified specialist.
Cefazolin injections during pregnancy - reviews
- I suffered from a terrible ARVI at 15 weeks of pregnancy, the doctor prescribed Cefazolin. At first it was scary, because the antibiotic is quite strong, but then I decided, because an infection can hit the baby much harder than medicine. Within 5 days I injected the drug, everything improved. We gave birth to a healthy baby, we feel great. Julia is 27 years old.
- The worst time is the 1st trimester, when the placenta, which is supposed to protect the fetus, is still developing. I believe that if the doctor said to take medicine, there is no need to argue! Experts always know best! Irina is 31 years old.
- During pregnancy, I read a lot about taking antibiotics during this period and got scared. As soon as it came to illness, I read about the dangers of infections for the baby, and immediately realized that being treated with antibiotics is much safer than waiting for the infection to subside on its own. I don’t regret it one bit, I’m healthy, my son is healthy, everything is fine. Katya is 24 years old.
- The urine test showed a lot of protein and leukocytes, I was very scared. The doctor prescribed Cefazolin Akos. I injected the drug for 5 days, took tests, everything is normal. Luda is 32 years old.
Thank you
Medicine Cefazolin is antibiotic belonging to the first generation of the group cephalosporins. Cefazolin is administered only by injection, since when taken orally (in the form of tablets) it is destroyed in the gastrointestinal tract, without having time to be absorbed into the blood and have antibacterial effect. The antibiotic has a wide spectrum of action, so it can be used to treat various infections caused by microbes sensitive to it. Cefazolin is used to treat organs of almost all systems, for example, respiratory, urinary, reproductive, skin, joints, etc.
Release forms and name
The antibiotic Cefazolin is available only in the form of a dry powder intended for the preparation of a solution for intramuscular or intravenous administration. The powder is packaged in glass bottles and hermetically sealed. On Latin the name of the drug is written as follows - cefazolin, which is international name antibiotic. Commercial names may differ from international ones, since each pharmaceutical company can produce a drug with the active ingredient cefazolin, but give it a memorable and simple name. For example, the antibiotic cefazolin is marketed under the following names: commercial names– Amzolin, Ancef, Atralcef, Vulmizolin, Zolin, Zolfin, Intrazolin, Ifizol, Kefzol, Lizolin, Nacef, etc. However, there are antibiotics whose name is the same as international name substances, for example, Cefazolin-AKOS, Cefazolin-Sandoz, etc. All listed drugs are the same thing - the antibiotic cefazolin, which is used as a standard, regardless of the name and manufacturer. Only the quality of the drug itself, produced by different pharmaceutical factories, may differ.
Dosage
Today, various pharmaceutical concerns produce Cefazolin in the following dosages:- 250 mg;
- 500 mg;
- 1 g (1000 mg).
Therapeutic effects and spectrum of action of Cefazolin
Cefazolin belongs to the semisynthetic antibiotics from the group of beta-lactams. These antibiotics kill pathogenic bacteria by destroying their cell wall. Cefazolin is capable of destroying many types of microorganisms, therefore it is a broad-spectrum antibiotic. Compared with other drugs from the group of first-generation cephalosporins, it is the most safe medicine because it has minimal toxicity.Main and main therapeutic effect Cefazolin is the destruction of the pathogenic microorganism that caused the infectious and inflammatory disease. Accordingly, the drug effectively cures infections and inflammations caused by microbes, on which Cefazolin has a detrimental effect.
To date, Cefazolin is effective against the following pathogenic microorganisms:
- Staphylococcus aureus (Staphylococcus aureus);
- Epidermal staphylococcus (Staphylococcus epidermidis);
- Beta-hemolytic streptococci from group A;
- Pyogenic streptococcus (Streptococcus pyogenes);
- Diplococcus pneumoniae;
- Hemolytic streptococcus (Streptococcus hemolyticus);
- Viridal streptococcus (Streptococcus viridans);
- Escherichia coli;
- Klebsiella spp.;
- Proteus (Proteus mirabilis);
- Enterobacter aerogenes;
- Haemophilus influenzae (Haemophilus influenzae);
- Salmonella (Salmonella spp.);
- Shigella (Shigella disenteriae, etc.);
- Neisseria (Neisseria gonorrhoeae and Neisseria meningitidis);
- Corynebacterium diphtheriae;
- The causative agent of anthrax (Bacillus anthracis);
- Clostridia (Clostridium pertringens);
- Spirochetes (Spirochaetoceae);
- Treponema (Treponema spp.);
- Leptospira spp.
The antibiotic does not act on Pseudomonas aeruginosa, Mycobacterium tuberculosis, viruses, fungi and protozoan microorganisms (Trichomonas, chlamydia, etc.).
Indications for use
Due to the fact that Cefazolin has a detrimental effect on many pathogenic microorganisms, it is used to treat infections various organs. Today, the indications for the use of Cefazolin are the following infectious and inflammatory diseases:- acute and chronic bronchitis;
- infected bronchiectasis;
- pneumonia caused by bacteria (not fungi or viruses);
- bronchopneumonia;
- chest infections that developed after surgical intervention(for example, after a puncture, etc.);
- pleural empyema;
- lung abscess;
- acute and chronic pyelonephritis;
- cystitis;
- urethritis;
- skin infections;
- carbuncles;
- infected gangrene;
- infection on a wound or burn surface;
- skin or soft tissue infection after surgery;
- eye infection;
- septic arthritis;
- biliary tract infections;
- infection after abortion;
- uterine infection;
- pelvic abscess;
- peritonitis.
Cefazolin injections - instructions for use
Cefazolin is administered intramuscularly or intravenously, after dissolving the required dose of powder in water, lidocaine or novocaine. The dosage and frequency of Cefazolin injections are determined by the severity of the person’s condition and the potential risk of infection. Injections are given in parts of the body where the muscle layer is well developed, for example, in the thigh, shoulder, buttock, etc. Cefazolin can be administered intravenously in the form of injections or droppers.
The powder should be diluted in necessary for a person dosage. For example, if you need to administer 0.5 g, then take a bottle with the appropriate dosage of Cefazolin powder. You cannot take a 1g bottle and split it in half to get a 500mg dose. But to get a dose of 1 g, you can take two bottles of 500 mg or four bottles of 250 mg.
Intravenous injections Cefazolin in a dosage of less than 1 g is administered as a slow injection. The solution is injected into a vein over 3 to 5 minutes. If Cefazolin is administered intravenously in a dosage of more than 1 g, then a dropper should be used. In this case, the antibiotic solution is administered for at least 30 minutes.
Antibiotic solutions must be prepared immediately before use. A high-quality solution must be transparent and not contain any impurities, suspended particles, sediment or turbidity. A slight yellowish tint of the finished solution is allowed, which is normal and does not indicate deterioration of the drug. If the resulting solution is not transparent, it cannot be used. It is also not allowed to use a solution prepared in advance. IN exceptional cases It is allowed to store the prepared solution in the refrigerator for no longer than 2 days.
The dosage of Cefazolin is determined by the severity of the pathology. Adults not suffering renal failure, should receive an antibiotic in the following dosages:
1.
Infections mild degree caused by cocci (staphylococci, streptococci) require the use of Cefazolin at a dose of 500 mg - 1 g every 12 hours. 500 mg can be administered every 8 hours. Maximum daily dose is 1.5 – 2 g.
2.
Acute uncomplicated infections urinary tract(urethritis, cystitis, etc.) – Cefazolin is administered 1 g every 12 hours. The daily dose of antibiotic is 2 g.
3.
Pneumonia caused by pneumococci requires the administration of Cefazolin 500 mg every 12 hours. The daily dosage of the antibiotic is 1 g.
4.
Severe or medium degree require the use of Cefazolin 500 mg - 1 g every 6 - 8 hours. The daily dose is 3 – 4 g.
5.
Infections, life threatening, are treated by administering 1 - 1.5 g of Cefazolin every 6 hours. In this case, a person receives 4–6 g of antibiotic per day.
It is possible to increase the dosage of Cefazolin to 12 g per day if in serious condition person when it is a matter of life and death. Elderly people without renal impairment receive Cefazolin at the usual adult dosage.
To prepare a solution for intramuscular injection, 2–3 ml of sterile water, 0.5% Lidocaine or 2% Novocaine are injected into a bottle with powder. After which the bottle is shaken vigorously until the powder is completely dissolved and a clear liquid is formed.
For intravenous injection, Cefazolin powder is dissolved in sterile water. In this case, at least 10 ml of water is needed to ensure the administration of the drug within 3 to 5 minutes. It is allowed to dilute the antibiotic in at least 4 ml of water per 1 g of powder.
A solution for intravenous infusion (dropper) is prepared using 100 - 150 ml of the main solvent. The following drugs are used as a solvent:
- sterile saline solution;
- 5% or 10% glucose solution;
- glucose solution in saline;
- glucose solution in Ringer's solution;
- 5% or 10% fructose solution in water for injection;
- Ringer's solution;
- 5% sodium bicarbonate solution.
Cefazolin with Novocaine and Cefazolin with Lidocaine - how to dilute?
To dilute Cefazolin powder you will need 2% Novocaine or 0.5% Lidocaine, which are sold in pharmacies in sealed ampoules. You will also need sterile syringes. Method for preparing a solution of Cefazolin on Novocaine or Lidocaine for intramuscular administration: 1. Carefully file and break off the tip of the ampoule with 2% Novocaine solution or 0.5% Lidocaine.
2. Open the sterile syringe, put on the needle and lower it into the ampoule with Novocaine or Lidocaine.
3. You need to draw the amount of Novocaine or Lidocaine into a syringe (2 or 4 ml).
4. Remove the syringe from the ampoule with Novocaine or Lidocaine.
5. Remove the metal cap from the bottle of Cefazolin powder.
6. Pierce the rubber cap of the bottle with Cefazolin with the syringe needle.
7. Carefully squeeze out the entire contents of the syringe into the bottle of powder.
8. Without removing the syringe, shake the bottle until the powder is completely dissolved.
9. Draw the prepared solution into a syringe.
10. Remove the syringe from the rubber stopper and turn it upside down with the needle.
11. Tap the surface of the syringe with your finger in the direction from the piston to the needle so that air bubbles collect at the base.
12. Press the plunger of the syringe to release the air.
13. Give an intramuscular injection.
The amount of Lidocaine or Novocaine is determined by the dosage of Cefazolin. To dilute 500 mg of Cefazolin, you will need 2 ml of Novocaine or Lidocaine solution. And to dilute 1 g of Cefazolin, you need 4 ml of Novocaine or Lidocaine.
Cefazolin injections - instructions for use for children
Cefazolin in infants can only be used if there is an urgent need and the child’s life is at risk. IN in this case The antibiotic is used only under medical supervision.The dosage of Cefazolin in children is determined by the severity of the pathology and the child’s body weight. It is by weight that the daily dose of the antibiotic is calculated, which is divided into 2 to 4 administrations. If the child suffers from renal failure, then the dosage is also affected by the indicator glomerular filtration(QC), determined according to the Rehberg test.
Dosages of Cefazolin for children who do not suffer from kidney pathology are as follows:
- For mild and moderate infections, the daily dosage is calculated at the rate of 25–50 mg of antibiotic per 1 kg of child’s weight. The resulting amount is divided into 2 - 4 administrations per day.
- For severe infections, the dosage is calculated at the rate of 100 mg of Cefazolin per 1 kg of child’s weight. The calculated daily dosage is divided into 3 to 4 administrations.
- Newborns and premature infants weighing less than 2 kg receive Cefazolin in a single dose of 20 mg per 1 kg, every 12 hours. That is, the daily dose of antibiotic is 40 mg per 1 kg of body weight.
- For children over 7 days old and weighing more than 2 kg, the daily dose of the drug is determined at the rate of 60 mg per 1 kg of weight.
If a child suffers from renal failure, then the algorithm for determining the dosage of Cefazolin is as follows:
1.
Calculate the dose based on body weight, as for a child who does not suffer from kidney pathology.
2.
Perform the Rehberg test and assess creatinine clearance.
3.
Calculate the dose of Cefazolin that can be administered to the child according to the ratios shown in the table:
However, the first dose of Cefazolin is administered completely to children suffering from renal failure. And then all subsequent ones are reduced to the required amount, depending on creatinine clearance.
Cefazolin injections for children - how to dilute?
For children, Cefazolin injections should be diluted exclusively with solutions of Novocaine or Lidocaine. Moreover, it is better to choose the anesthetic that has the best analgesic effect in this particular child. In most cases, Lidocaine has a more pronounced analgesic effect, so it is recommended to use this particular drug to prepare Cefazolin solution for injections. If possible, you can give the child one injection of Cefazolin with Novocaine, and one with Lidocaine, so that the baby himself can evaluate which solution has the best analgesic effect.Cefazolin powder for intramuscular injections Children are diluted immediately before use. An antibiotic dose of less than 500 mg is diluted in 2 ml of Novocaine or Lidocaine. A dose of more than 500 mg requires 4 ml of Lidocaine or Novocaine. The sequence of actions for diluting Cefazolin is as follows:
1.
Open the ampoule with Lidocaine or Novocaine, dip the tip of the syringe needle into the solution.
2.
Take the required amount of solution - 2 or 4 ml of Novocaine or Lidocaine.
3.
Pierce the cap of the bottle with Cefazolin powder with a needle.
4.
Pour Novocaine or Lidocaine into the bottle and, without removing the needle, vigorously mix the contents to obtain a solution.
5.
Carefully draw the entire contents of the bottle into the syringe.
6.
Remove the syringe from the bottle and give an intramuscular injection.
Use during pregnancy
Cefazolin crosses the placenta and affects the fetus, so the antibiotic can be used during pregnancy only if there is absolute readings when there is a threat to the mother's life. To date, it is not clear exactly what effect Cefazolin has on the fetus, therefore, when deciding whether to use an antibiotic in pregnant women, it is necessary to carefully weigh the possible risk/expected benefit ratio. To date, Cefazolin has only been tested in pregnant rats. Moreover, the drug in large doses did not cause a teratogenic effect, that is, it did not lead to the formation of congenital deformities of the fetus. However, for obvious reasons, such controlled studies have not been conducted in pregnant women.
Cefazolin also passes into breast milk, although there it is detected in small concentrations. However, if it is necessary to use it during breastfeeding, the child should be switched to artificial formula for the duration of treatment.
How to inject the antibiotic Cefazolin?
Cefazolin should be administered intramuscularly only to those parts of the body where a person has a well-developed muscle layer. Usually this is the front and side of the thigh, buttocks, shoulders or abdominal Press. Since the injection is very painful, and a lump often forms at the injection site, it is recommended to change the injection areas one by one. For example, one injection is placed in the buttock, the second in the thigh, the third in the shoulder, and the fourth in the abdominals. Then they start again with the buttock, and so alternate the injection sites for Cefazolin until the very end of the course of treatment. The intramuscular injection should be done slowly - over at least 3 - 5 minutes, gradually introducing the medicine. The needle should be inserted deep into the muscle so that the medicine does not enter the subcutaneous tissue. fatty tissue. After administration of Cefazolin, you should not heat the injection site, as this may lead to the development of aseptic inflammation. When injecting Cefazolin, you should follow General requirements to perform these medical procedures:
1.
Treat the injection site with an antiseptic (70% alcohol, etc.).
2.
Use only a sterile syringe with a sterile needle.
3.
Release the air from the syringe with the prepared solution.
4.
Position the needle vertically to the surface of the skin and insert it deep into the muscle.
5.
Slowly press the plunger, injecting the medicine over 3 to 5 minutes.
6.
After injecting the entire solution, remove the needle, holding it by the edge placed on the syringe.
7.
Treat the injection site with an antiseptic.
Many people use needles for intramuscular Cefazolin injections (especially for children). intravenous injections in an effort to reduce pain. However, this cannot be done, since a thin needle for intravenous injections quite often slips out and goes into the thickness of the muscles, remaining there for a long time. long years and causing inconvenience to a person. Surgeons often encounter similar phenomena when they have to remove syringe needles from buttocks and thighs that broke off and went into the “muscle” several years ago. In addition, the use of a thinner needle does not reduce the pain of Cefazolin administration.
How much to inject Cefazolin?
The duration of use of Cefazolin depends on the severity of the infection and the speed of recovery. The course of treatment lasts from 7 to 14 days. Cefazolin injections should not be used for less than 5 or more than 15 days, since in this case there is high risk development of antibiotic-resistant types of microorganisms. These resistant microorganisms can re-cause an infection that will have to be treated again, only with the use of another, even stronger antibiotic. Unfortunately, there is a high risk that the microorganism may be resistant to another antibiotic. In this case, the prognosis for life is unfavorable, since there are very few antibiotics in the world that can cope with resistant microbes. And if they do not help, then you can only count on the immunity of the sick person.That is why the use of antibiotics, including Cefazolin, must be taken responsibly. You should not give up injections as soon as a person feels better, considering the treatment to be over. At least 5 days of Cefazolin injections must be given, overcoming pain and reluctance. This is especially true for children. After all, a child can “acquire” resistant types of microbes faster and easier than an adult, which will constantly cause infections that are difficult to treat.
Side effects
Most of the side effects of Cefazolin concern organs gastrointestinal tract, or limited by increased sensitivity. If a person suffers from hypersensitivity to any other medications, then the risk of developing it to Cefazolin is also high. In addition, it develops relatively often increased sensitivity to an antibiotic in people who are prone to allergic reactions, bronchial asthma, urea rash and creatinine in the blood according to laboratory tests. When using large doses of antibiotics, the functional activity of the kidneys may be impaired. In this case, the dosage of Cefazolin is reduced, and further treatment is carried out under constant monitoring of the concentration of urea and creatinine in the blood. Local reactions. The main local reaction is severe pain when the antibiotic is administered. In some cases, a lump may form at the injection site. In rare cases, intravenous administration of an antibiotic can trigger the development of phlebitis.
Other organs and systems. Cefazolin may lead to the development of such side effects like dizziness, feeling of squeezing in chest, convulsions, dysbiosis, addition of another infection, candidiasis (candidal stomatitis or vaginitis). If candidiasis develops or another infection occurs, it is necessary to decide on the further advisability of using Cefazolin.
Contraindications
If you are allergic to any other antibiotics from the cephalosporin group, Cefazolin is strictly prohibited for use. If a person is allergic to penicillin antibiotics, then Cefazolin is administered carefully, having prepared a kit to combat anaphylactic shock, since there is cross-allergenicity between these two groups of drugs.The antibiotic is also contraindicated for use during pregnancy and breastfeeding. Cefazolin is not administered to infants under 1 month of age, since there is no scientifically proven data on its safety for newborns.
Analogs
Today, the antibiotic Cefazolin is produced under different names, but all these drugs are synonymous, since they contain the same active substance. All synonyms of Cefazolin are a powder intended for the preparation of a solution for intramuscular or intravenous administration. On the domestic pharmaceutical market There are the following synonyms for Cefazolin: - Amzolin;
- Anceph;
- Atralcef;
- Vulmizoline;
- Zolin;
- Zolfin;
- Intrazolin;
- Ifizol;
- Kefzol;
- Lysolin;
- Natsef;
- Orizolin;
- Orpin;
- Prozoline;
- Reflin;
- Totacef;
- Cesolin;
- Cefazolin-Biochemi;
- Cefazolin-Watham;
- Cefazolin-KMP;
- Cefazolin Nycomed;
- Cefazolin-Sandoz;
- Cefazolin-Teva;
- Cefazolin-Elfa;
- Cefazolin-AKOS;
- Cefazolin-Ferein;
- Cefazolin sodium;
- Cefamezine;
- Cefaprim;
- Cefezol;
- Cefzolin;
- Cefopride.
- Cephalexin granules, capsules, powder and tablets;
- Cephalothin powder;
- Ecocephron capsules.
Cephalosporin antibiotic, classified as semi-synthetic antimicrobial agent, is Cefazolin. What do these injections help with? The drug has wide range bactericidal action. The medicine "Cefazolin" instructions for use suggests using it for therapy infectious pathologies caused by gram-negative and gram-positive pathogenic microorganisms.
Release form and composition
"Cefazolin" is available in powder form for the preparation of a solution for intramuscular or intravenous administration. Sold in bottles of 0.5, 1 and 2 g. Sodium salt“Cefazolin” is the active component of the antibiotic (500, 1000, 2000 mg, respectively, in one bottle).
Pharmacological properties
The drug "Cefazolin", the instructions for use provide such information, is the least toxic cephalosporin antibiotic with a wide spectrum of action. It belongs to the semi-synthetic antimicrobials from the group of beta-lactams. This group of antibiotics kills pathogenic bacteria and microbes, destroying their cell walls.
According to the instructions, Cefazolin exhibits increased activity against gram-positive and gram-negative microorganisms: staphylococci, diplococcus pneumoniae, enterobacteria, coli, salmonella, klebsiella, shigella, proteus, pathogen anthrax, Haemophilus influenzae, clostridia, treponema, spirochetes, etc. The antibiotic has no effect on mycobacterium tuberculosis, Pseudomonas aeruginosa, fungi, viruses and protozoan microorganisms.
Cefazolin injections: what does the medicine help with?
Indications for the use of Cefazolin are as follows: 
- infectious skin diseases;
- blood poisoning;
- peritonitis and sepsis;
- inflammation of the lining of the heart;
- bone and joint infections;
- infectious diseases of the respiratory tract;
- venereal diseases;
- skin infections after burns, surgical interventions and wounds;
- infections of the biliary and urinary tract;
- mastitis;
- inflammation in the abdominal cavity and pelvic organs.
Why is Cefazolin still prescribed? Only a doctor knows the exact indications for the use of Cefazolin. For example, he may recommend a drug for sore throat, skin infections or blood poisoning. Injections help with blood infections, peritonitis, meningitis, and many infectious diseases.
Instructions for use
"Cefazolin" is prescribed intramuscularly, intravenously (stream or drip). The average daily dose for adults is 0.25-1 g; frequency of administration - 2-4 times a day. The maximum daily dose is 6 g (in rare cases - 12 g). The average duration of treatment is 7-10 days.
To prevent postoperative infection - 1 g intravenously 0.5-1 hour before surgery, 0.5-1 g during surgery and 0.5-1 g every 8 hours during the first day after surgery. Children 1 month and older - 25-50 mg/kg per day; at severe course infections, the dose can be increased to 100 mg/kg per day. The frequency of administration is 2-4 times a day.
Preparation of solutions for injections and infusions: 0.5 g of the drug is dissolved in 2 ml of water for injection (can be used in the case of intramuscular administration of the drug Novocain to reduce pain at the injection site), 1 g - in 4 ml of water for injection. For intravenous bolus administration, the resulting solution is diluted with 5 ml of water for injection, then administered slowly over 3-5 minutes.
For intravenous drip administration, the drug is diluted with 50-100 ml of 5% or 10% dextrose solution, 0.9% sodium chloride solution, Ringer's solution, 5% sodium bicarbonate solution. During dilution, the vials must be shaken vigorously until completely dissolved.
Contraindications
The instructions for Cefazolin indicate that the antibiotic cannot be prescribed in the following cases:
- when breastfeeding;
- during pregnancy;
- up to 1 month of age;
- with hypersensitivity to drugs from the cephalosporin group.
Side effects
According to the instructions, the use of the drug "Cefazolin" can cause the following side effects: 
- allergies: urticaria, eosinophilia, itching, fever;
- local reactions: painful sensations at the site of intramuscular injection;
- organs digestive system: diarrhea, nausea, vomiting;
- chemotherapeutic effect: candidiasis, pseudomembranous colitis.
In rare cases, there is a transient increase in the activity of liver transaminases, anaphylactic shock, arthralgia, angioedema, leukopenia (reversible), thrombocytopenia, neutropenia, renal dysfunction.
What are the analogues of the drug "Cefazolin"
Complete analogues for the active substance:
- Anceph.
- Zolin.
- Ifizol.
- Intrazolin.
- Lysolin.
- Kefzol.
- Natsef.
- Orpin.
- Orizolin.
- Totatsef.
- Cefamezin.
- Cesolin.
- Cefazolin sodium.
- Cefazolin Sandoz (Elfa, Biochemi, -AKOS, -Ferein).
- Cefezol.
- Cefopride.
- Cefazolin sodium salt.
- Cefaprim.
Price, holiday conditions
You can buy it with a doctor's prescription. average price"Cefazolin", powder for preparing a solution (Moscow), costs 29 rubles. In Minsk the drug costs 78 Bel. kopecks In Kyiv, the solution is sold for 50 hryvnia, in Kazakhstan - for 1200 tenge.
Published on this page detailed instructions by application antibiotic Cefazolin. Available dosage forms the drug (powder in ampoules for injections), as well as its analogues. Information is provided on the side effects that Cefazolin can cause and on interactions with other medications. In addition to information about diseases for the treatment and prevention of which they are prescribed medicine(sore throat, bronchitis, pneumonia, sepsis), admission algorithms are described in detail, possible dosages for adults, for children, the possibility of use during pregnancy and breastfeeding is being clarified. The abstract for Cefazolin is supplemented with reviews from patients and doctors. Instructions are given on how to dilute the powder form of the drug and what solutions to use (novocaine, lidocaine, water for injection).
Instructions for use and dosage
Intramuscularly, intravenously (stream and drip (dropper)). The average daily dose for adults is 0.25-1 g; frequency of administration - 3-4 times a day. The maximum daily dose is 6 g (in rare cases - 12 g). The average duration of treatment is 7-10 days.
To prevent postoperative infection - 1 g intravenously 0.5-1 hour before surgery, 0.5-1 g during surgery and 0.5-1 g every 8 hours during the first day after surgery.
Children 1 month and older - 25-50 mg/kg per day; in case of severe infection, the dose can be increased to 100 mg/kg per day. The frequency of administration is 3-4 times a day.
Preparation of solutions for injections and infusions: 0.5 g of the drug is dissolved in 2 ml of water for injection (can be used in the case of intramuscular administration of the drug Novocain to reduce pain at the injection site), 1 g - in 4 ml of water for injection. For intravenous bolus administration, the resulting solution is diluted with 5 ml of water for injection, then administered slowly over 3-5 minutes. For intravenous drip administration, the drug is diluted with 50-100 ml of 5% or 10% dextrose solution, 0.9% sodium chloride solution, Ringer's solution, 5% sodium bicarbonate solution.
During dilution, the vials must be shaken vigorously until completely dissolved.
Release forms
Powder for the preparation of a solution for intravenous and intramuscular administration (injections in ampoules for injection).
Cefazolin- 1st generation cephalosporin antibiotic. Acts bactericidal.
Has a wide spectrum of antimicrobial action. Active against both gram-positive and gram-negative microorganisms. Also active against Spirochaetaceae and Leptospiraceae.
The drug is not effective against P. aeruginosa, indole-positive strains of Proteus spp., M. tuberculosis, and anaerobic microorganisms.
Pharmacokinetics
It is destroyed when taken orally. Penetrates into organs and tissues of the body (including joints, cardiovascular system, abdominal cavity, kidneys and urinary tract, middle ear, placenta, Airways, skin and soft fabrics). In patients with normal function bile ducts, the concentration in the gallbladder tissue and bile is significantly higher than in plasma. With obstruction of the biliary tract, the concentration in bile is significantly less than in plasma. Metabolized in the liver. Excreted unchanged by the kidneys during the first 6 hours - 60-90%, after 24 hours - 70-95%.
Indications
Infectious and inflammatory diseases caused by pathogens sensitive to the drug:
- sepsis;
- peritonitis;
- endocarditis;
- respiratory tract infections;
- genitourinary tract infections, including syphilis and gonorrhea;
- infectious lesions of bones and joints.
Prevention of postoperative complications.
Contraindications
- pregnancy;
- lactation;
- newborns;
- hypersensitivity to drugs of the cephalosporin group and other beta-lactam antibiotics.
special instructions
Patients with a history of allergic reactions to penicillins may have increased sensitivity to cephalosporin antibiotics.
The drug is prescribed with caution to patients with gastrointestinal diseases (especially colitis).
When using cefazolin, positive direct and indirect Coombs tests may occur.
When using cefazolin, it is possible to obtain a false positive reaction to glucose in the urine.
The safety of the drug in premature infants and children in the first month of life has not been established.
Side effect
- hives;
- chills;
- fever;
- rash;
- bronchospasm;
- angioedema;
- anaphylactic shock;
- nausea, vomiting;
- diarrhea or constipation;
- flatulence;
- abdominal pain;
- dysbacteriosis;
- stomatitis;
- glossitis;
- pseudomembranous enterocolitis;
- leukopenia, neutropenia, granulocytopenia, thrombocytopenia, hemolytic anemia;
- impaired renal function (azotemia, increased urea levels in the blood, hypercreatininemia);
- anal itching;
- itching of the genitals;
- phlebitis;
- pain along the vein;
- pain and infiltration at the site of intramuscular injection;
- superinfection;
- candidiasis.
Drug interactions
Loop diuretics and drugs that block tubular secretion increase the concentration of cefazolin in plasma.
Aminoglycosides increase the risk of developing kidney damage.
Pharmaceutically incompatible with aminoglycosides (mutual inactivation). Lidocaine should not be used to prepare a solution for intravenous administration (jet or drip).
Analogues of the drug Cefazolin
Structural analogues of the active substance:
- Anceph;
- Zolin;
- Intrazolin;
- Ifizol;
- Kefzol;
- Lysolin;
- Natsef;
- Orizolin;
- Orpin;
- Totacef;
- Cesolin;
- Cefazolin sodium;
- Cefazolin Sandoz;
- Cefazolin Elfa;
- Cefazolin AKOS;
- Cefazolin Ferein;
- Cefazolin sodium salt;
- Cefamezine;
- Cefaprim;
- Cefezol;
- Cefopride.
Use during pregnancy and breastfeeding
Taking the drug during pregnancy is contraindicated. If necessary, use the drug breast-feeding stop.
In this medical article can be found medicine Cefazolin. The instructions for use will explain in what cases injections can be taken, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the forms of release of the drug and its composition.
In the article, doctors and consumers can only leave real reviews about Cefazolin, from which you can find out whether the medicine helped in the treatment of sore throat, sepsis and other infections in adults and children, for which it is also prescribed. The instructions list analogues of Cefazolin, prices of the drug in pharmacies, as well as its use during pregnancy.
Cefazolin is a cephalosporin antibiotic that belongs to the group of semisynthetic antimicrobial drugs. Instructions for use indicate that injections in injection ampoules have a wide spectrum of bactericidal action.
Release form and composition
Cefazolin is available in powder form for the preparation of a solution and its subsequent injection intramuscularly or intravenously. Powder in bottles from clear glass cardboard box, the drug is accompanied by a detailed annotation describing the characteristics of the antibiotic.
Powder white or almost white, when dissolved, turns into transparent colorless liquid with a slight specific odor. Each bottle contains 250 mg, 500 mg or 1 g of active active substance– Cefazolin in the form of sodium salt.
pharmachologic effect
Cefazolin is the least toxic cephalosporin antibiotic with a wide spectrum of action. It belongs to semisynthetic antimicrobial drugs from the beta-lactam group. This group of antibiotics kills pathogenic bacteria and microbes by destroying their cell walls.
Cefazolin exhibits increased activity against gram-positive and gram-negative microorganisms: staphylococci, diplococcus pneumoniae, enterobacteria, E. coli, salmonella, Klebsiella, Shigella, Proteus, anthrax, Haemophilus influenzae, clostridia, treponema, spirochetes, etc.
The antibiotic has no effect on Mycobacterium tuberculosis, Pseudomonas aeruginosa, fungi, viruses and protozoan microorganisms.
Indications for use
What does Cefazolin help with? Injections are prescribed if the patient has:
- inflammation in the abdominal cavity and pelvic organs;
- bone and joint infections;
- peritonitis and sepsis;
- skin infections after burns, surgeries and wounds;
- venereal diseases;
- blood poisoning;
- infectious diseases of the respiratory tract;
- infectious skin diseases;
- inflammation of the lining of the heart;
- mastitis;
- infections of the biliary and urinary tract.
For what purpose the drug will be effective in each individual case, it is necessary to consult a specialist. Only a doctor knows the exact indications for the use of Cefazolin. For example, he may recommend a drug for sore throat, skin infections or blood poisoning.
Injections help with blood infections, peritonitis, meningitis, and many infectious diseases.
Instructions for use
Cefazolin injections are administered intramuscularly, intravenously (stream and drip (in the form of a dropper)). The average daily dose for adults is 0.25-1 g; frequency of administration - 2-4 times a day. The maximum daily dose is 6 g (in rare cases - 12 g). The average duration of treatment is 7-10 days.
To prevent postoperative infection - 1 g intravenously 0.5-1 hour before surgery, 0.5-1 g during surgery and 0.5-1 g every 8 hours during the first day after surgery. Children 1 month and older - 25-50 mg/kg per day; in case of severe infection, the dose can be increased to 100 mg/kg per day. The frequency of administration is 2-4 times a day.
Preparation of solutions for injections and infusions: 0.5 g of the drug is dissolved in 2 ml of water for injection (can be used in the case of intramuscular administration of the drug Novocain to reduce pain at the injection site), 1 g - in 4 ml of water for injection.
For intravenous bolus administration, the resulting solution is diluted with 5 ml of water for injection, then administered slowly over 3-5 minutes.
For intravenous drip administration, the drug is diluted with 50-100 ml of 5% or 10% dextrose solution, 0.9% sodium chloride solution, Ringer's solution, 5% sodium bicarbonate solution. During dilution, the vials must be shaken vigorously until completely dissolved.
Read also: what helps and how to take an antibiotic.
Contraindications 
- lactation period;
- children up to one month old;
- pregnancy;
- hypersensitivity to medications of the cephalosporin group.
Side effects
During treatment with Cefazolin injections, side effects occur in patients with hypersensitivity to cephalosporins:
- from the authorities respiratory system– shortness of breath, bronchospasm, swelling of the mucous membranes of the respiratory tract;
- from the hematopoietic organs - leukopenia, decreased platelet levels, granulocytopenia, hemolytic anemia, increased prothrombin time;
- local reactions - pain along the vein, puncture of the vein, formation of a hematoma, formation of a painful infiltrate at the injection site, redness and swelling of the skin at the site of drug administration;
- allergic reactions - urticaria, skin itching, dermatitis, toxic epidermal necrolysis, development of Quincke's edema, anaphylactic shock;
- from the genitourinary system - impaired renal function, development interstitial nephritis, itching of the genitals as a result of dysbacteriosis, thrush in women;
- from the digestive system - the formation of painful ulcers in oral cavity, candidal stomatitis, dry mouth, heartburn, belching, nausea, lack of appetite, vomiting, diarrhea, development of colitis, impaired liver function, development of acute pancreatitis.
If you experience any side effects from injections of the drug, you should definitely inform your doctor. If during the administration of the medicine the patient experiences a feeling of shortness of breath, heat in the face, shortness of breath, tachycardia, chills, this should be reported immediately medical worker and stop administering the solution.
Children, pregnancy and breastfeeding
Contraindicated during pregnancy and lactation.
In childhood
Contraindicated for children under 1 month and premature infants due to the fact that the safety of use in these groups of patients has not been established.
special instructions
Patients with a history of allergic reactions for drugs of the penicillin group, before starting therapy with Cefazolin, you should consult your doctor. Typically, such patients have increased sensitivity to cephalosporins.
Patients with chronic diseases gastrointestinal organs, especially with colitis, including a history, you should definitely consult a doctor before starting therapy. During injection therapy, the patient's condition should be carefully monitored; if symptoms of colitis occur, it is recommended to immediately stop treatment.
With a correctly calculated dose, the drug does not have a depressing effect on the functioning of the central nervous system. nervous system and does not slow down the speed of psychomotor reactions.
Drug interactions
When the drug is combined with aminoglycosides, Rifampicin, Vancomycin, a synergistic antimicrobial effect is observed. Aminoglycosides increase the likelihood of kidney damage. The drug is incompatible with them.
It is not advisable to combine the medication with anticoagulants and diuretics.
Interaction with agents that inhibit tubular secretion increases the level active substance drug in the blood, increases the likelihood of toxic reactions and slows down the elimination time.
Analogues of the drug Cefazolin
Analogues are determined by structure:
- Cefopride.
- Cefaprim.
- Orpin.
- Cefamezin.
- Cefazolin Sandoz (Elfa, Biochemi, AKOS, Ferein).
- Cefazolin sodium salt.
- Kefzol.
- Intrazolin.
- Ifizol.
- Cefazolin sodium.
- Anceph.
- Zolin.
- Natsef.
- Totatsef.
- Cesolin.
- Lysolin.
- Orizolin.
- Cefezol.
Vacation conditions and price
The average cost of Cefazolin (powder for solution 1 g) in Moscow is 29 rubles. The drug is sold in pharmacies with a prescription.
It is recommended to store bottles of powder in a cool place out of reach of children. Avoid direct sunlight exposure of the drug. The shelf life of the powder is 3 years from the date of manufacture. Do not use a drug that has expired.
The solution should be prepared immediately before administration; it is unacceptable to store the prepared solution until the next injection.
Loading...