The drug Mexidol is indicated for use as an injection. Mexidol intramuscularly or intravenously, which is better?

The indications of the drug are related to different areas of medicine. And it is quite natural that the product is of interest to many categories of consumers, even those who do not have any serious problems with the activity of the brain and nervous system. To understand in what cases the drug is most effective to use, you must first learn about its purpose.

Indications of Mexidol

The main effect of the drug is associated with its nootropic effect. It has primarily a stress-protective effect. The pharmacological product contains one active substance - ethylmethylhydroxypyridine succinate. It has a whole set of properties that can improve brain activity, prevent sclerotic processes, and improve cerebral circulation.

That is, Mexidol can be used primarily in for preventive purposes. But it is also prescribed after a stroke and for initial stages atherosclerosis. If we take into account the peculiarities of the action of injections on the body, we can present the readings as follows:

• history of stroke and ischemic disease in combination with other medications;
• previous traumatic brain injuries, mild concussion;
• dysfunction of the circulatory system (for example, VSD);
• deterioration of cognitive functions due to previous diseases and age-related changes;
• neuroses that cause increased anxiety or fear;
• pronounced irritability due to accumulated or sudden stress;
• consequences of drug and alcohol use.

Due to such an impressive list of indications, the drug is prescribed not only to sick people, but also for preventive purposes. The product helps maintain high performance, protects against stress factors and deterioration of brain activity due to exhaustion or consumption of alcoholic beverages.

“Side” consequences include improved memory, increased cognitive functions, and relief of emotional stress. Thus, even completely healthy people this drug may be prescribed. True, it must be used correctly to achieve this effect.

Instructions for use

A standard package contains 5–10 2 ml ampoules. The injections are given intramuscularly. Intravenous administration is permissible only in a hospital setting through a drip. Intravenous injection is acceptable. But, again, only under the supervision of a specialist. At home, the best option is to perform intramuscular injections in the buttock.

In each case, the dosage, frequency and duration of use should be determined by a doctor. Mexidol should be used independently only for preventive purposes in order to avoid anxiety disorders and decreased mental abilities. In this situation, the following rules must be taken into account.

1. The maximum dosage for intramuscular administration is 600 mg per day. But it’s better to start with 200 mg per day. Only if there is no result, the dose is increased over time. The ampoules of the drug contain different parts active substance. The most common is Mexidol 5%. But, if you plan to use the maximum dosage, it is worth purchasing Mexidol 10% ampoules.
2. The daily dosage is divided into 2 administrations - morning and evening. Injections are usually easily tolerated. The administration of the drug does not cause pain or burning sensation. It is no coincidence that doctors prescribe the drug even to children under 12 years of age, and in exceptional cases- and infants.
3. The prophylactic course lasts 10–14 days. It is impossible to give injections for longer without the supervision of a doctor. If you want to enhance the effect, after this period it is better to switch to the tablet form. Again, this is only possible if there are no side effects.

Patients usually treat the intramuscular administration of Mexidol with caution, because they consider the method to be ineffective. But experts say that there is little difference between intramuscular and intravenous administration No. One has only to note that the most pronounced results can be obtained by performing injections together and taking Mexidol tablets.

Now it’s worth considering the reviews about the drug, which turn out to be much more useful than the “dry” recommendations of specialists. Now the medicine is prescribed often, so enough impressions have accumulated to draw conclusions about the effectiveness of the injections. How exactly do patients respond to him?

Reviews about injections

“I got rid of constant migraines”

The doctor prescribed a course of Mexidol for the reason that I was constantly having headaches. I had migraines almost all the time for two months, without stopping. Then they gave intramuscular injections for two weeks. I didn’t feel any particular inconvenience. Only at first dizziness appeared about half an hour after administration. Then the headaches began to subside. After the course, migraines occurred rarely - maybe once a month, no more. I can say for sure that Mexidol helped. Life has become much easier.

“Simply incredible effect”

About six months ago I was diagnosed with cerebrovascular insufficiency. Some people might be scared by this name. In fact, the disease manifests itself only in periodic dizziness and headaches... Be that as it may, they prescribed a course of Mexidol intramuscularly. I'm simply amazed at the results you can get from it! Judge for yourself - after almost every injection I felt better. Not only did the pain go away, but my hearing also improved. I have much more strength to work. The mood is also high. In general, the impressions are the most positive. I just want to warn you that it is not advisable to use it yourself. It's better to go to the doctor first and get a consultation.

“I coped with apathy and normalized sleep”

I have been plagued by hypotension since a young age. Constant sleepiness– this is familiar to me. But lately it has been getting worse and worse. Apathy appeared, I didn’t want to do anything. I even felt that I was starting to have trouble “thinking”—everything was falling out of my hands, and I couldn’t work effectively. Saved by Mexidol. The doctor prescribed it for support. I read the discussions on the forums. Started using it. Here are the changes that happened after a couple of weeks:

• drowsiness completely disappeared throughout the day;
• I started sleeping as per the schedule - no problems with falling asleep and waking up;
• my head became completely clear and I began to cope with things easily;
• appeared positive attitude, which has never happened before.

In general, as you can imagine, I am completely satisfied. At home, of course, it is inconvenient to give injections. But, if you have someone to do it, then you can definitely do it. Just inject it a couple of times a day, and after 2 weeks you are already a completely new person.

Mexidol should not be considered as some harmless “vitamins”. This is a powerful nootropic medicine, the independent use of which does not always lead to positive consequences. It is not enough to read the instructions before taking it. You should also visit a specialist who will give complete recommendations. In this case, you can guarantee that the result will be excellent.

This medicine belongs to the category of antioxidant drugs. It is used primarily to treat neurological pathologies. Mexidol injections according to the instructions for use contribute to:

• improvement of metabolic processes;
• regeneration of cell structure.

These properties make it possible to ensure stabilization of the patient’s psycho-emotional background. The medicine is prescribed only for the treatment of adult patients.

The drug is produced in the form of an injection solution. It is sold in glass ampoules with a volume of 2 or 5 ml. The active ingredient of the drug is ethylmethylhydroxypyridine succinate. The amount of this active substance in 1 ml of liquid is 50 mg.

Additional components of the drug are:

• sodium metabisulfite;
• injection water.

pharmachologic effect

The active substance of the drug provides the following effects:

• Antihypoxic. There is an increase in cellular resistance during oxygen starvation body.
• Membranoprotective. The drug protects blood cell membranes from negative destructive factors, free radicals, and endogenous toxins.
• Nootropic. The product protects cells of the entire nervous system when exposed to unfavorable factors due to a lack of oxygen supply to the blood.
• Anticonvulsant. The medicine blocks increased pulsation pathological nature in neurons of motor centers various structures nerve systems.
• Anxiolytic. The medication improves brain functionality, suppresses feelings of anxiety and attacks of fear.

The presence of therapeutic effects of Mexidol ensures the following tasks:

• normalization correct exchange substances at the cellular level in the nervous system;
• improving the rheological parameters of blood, thereby reducing its viscosity;
• reducing the process of platelet adhesion;
• decreased enzyme intoxication when pancreatitis is diagnosed;
• significant improvement in metabolic processes in the heart muscle.

A similar result is achieved by increasing ethylmethylhydroxypyridine succinate, which promotes the activity of a special enzyme, superoxide dismutase. Mexidol injections help improve the adaptation capabilities of the human body under the negative influence of stressful situations.

Indications for use

Mexidol injections according to the instructions are used for adults in the treatment of pathological processes and their prevention. Using medicine for prevention, a person manages to protect the body from the appearance of somatic diseases before anticipated stressful events. When a person is actively affected by stressors, the medication will help minimize their negative impact, protecting cardiomyocytes from overload.

If it is impossible to avoid negative phenomena, the medicine is prescribed in the following situations:

• ischemia of cardiac tissue;
• consequences of TBI;
• dystonia;
• damage to the soft tissue of the brain (mild lesions);
• encephalopathy of various types;
• neurogenic and mental disorders;
• asthenia;
• open-angle glaucoma;
• purulent-necrotic phenomena affecting the peritoneal organs.

Important! This medicine is not used to treat childhood diseases. Reliable positive clinical achievements confirming the safety of this medicine in childhood, not installed. Mexidol is also not recommended for use in the treatment of pathologies in women carrying a child and during lactation.

Contraindications for use

The drug should not be used in the following situations:

• acute renal or hepatic inflammatory processes;
• severe allergy to the composition of the medicine;
• high blood pressure;
• bronchial asthma.

Some patients experience unpleasant discomfort after injections:

• dry mouth;
• gagging;
• nausea;
• fatigue;
• notice redness on the skin;
• drowsiness;
• significant metallic taste inside the mouth;
• apathetic state.

Directions for use and doses

Mexidol, according to the instructions for use, should be administered by injection intramuscularly or intravenously only in inpatient conditions. Intravenous use of the medication is carried out through a slow stream for 5–7 minutes or by drip, with preliminary dissolution of the medicine in a special saline solution.

The daily dose of the drug is about 1200 mg. The choice of regimen, as well as the dosage of using liquid for injection, depends only on the severity of the ongoing pathological process. For adults, the maximum dose per day is 1.2 g. For prophylactic purposes, the medicine is administered only intramuscularly.

To stop the acute phase of the pathological condition, a drip is prescribed (the medication is administered intravenously with preliminary dissolution in physiological solution). Subsequently, maintenance therapy is prescribed using intramuscular injections.

The duration of the therapeutic course depends on the progression of the inflammatory reaction:

• If there is a disruption in the blood supply to the brain cells, the drug is administered at a dose of 0.2-0.5 g 2-4 times daily during the first 2 weeks. Over the next 2 weeks, the drug is prescribed in a dosage of 0.1-0.25 g no more than 3 times a day.
• In acute ischemia of cardiac tissue, the drug is used as part of the main course of treatment. In the very first 5 days, the drug is administered intravenously, very slowly, after which injections are performed into the muscle for the next 9 days. The dose of the drug is selected according to the diagnosis and weight of the patient. The dose is from 2 mg/kg to 3 mg/kg of the patient’s body weight per dose.
• For TBI, a two-week course of 0.2-0.5 g of medication is administered intramuscularly in the mornings and evenings.
• For discirculatory encephalopathy, the drug is used only in the acute phase - 0.2-0.5 g. In some cases, the course is continued up to 2 times a day for 2 weeks. Injections are given into a vein. Subsequently, reduce the dose to 0.1-0.25 g per day intramuscularly. If it is necessary to carry out a preventive course of DEP, the medication is administered in a dosage of 0.2-0.25 g for two weeks by intramuscular injection.
• In case of poisoning with antipsychotics, the medicine is administered only intravenously. Daily dosage is 0.2-0.5 g. Therapy is continued for about 14 days.
• Treatment of glaucoma involves the use of intramuscular injections for 2 weeks.
• Traumatic brain injuries require complex therapy - use an intravenous drip of 200-500 mg up to 4 times a day. The course is continued for 10-15 days.
• For the treatment of acute peritonitis, the dosage is selected strictly individually; everything in this situation depends only on the neglect of the process. The drug is used before and after surgery in order to achieve a lasting clinical effect. The medicine is withdrawn gradually, with a slow reduction in the dose used over a certain period.
• If you feel constant anxiety, intramuscular injections are recommended in a dosage of 100-300 ml once a day. Therapy takes 10-30 days.
• For a hangover in a chronic alcoholic, the medicine is used intramuscularly and an intravenous drip of 200-500 mg is prescribed up to three times a day. Therapy is continued for 7 days.
• For acute edematous pancreatitis, the medicine is used 3 times a day, 200-500 ml. It is administered intravenously through a drip, and intramuscular injections are also given.
• For mild necrotic lesions of the pancreas, the medication is prescribed 100-200 ml three times a day intravenously through a dropper or intramuscularly.
• With a similar diagnosis, but in the middle stage of damage to the pancreas, the treatment regimen involves using 200 ml three times a day by drip.
• In case of a severe pathological process (necrotizing pancreatitis), the dosage of the substance is 800 ml 2 times on the very first day, and then it is reduced to 200-500 ml.
• In a situation with myocardial infarction in the acute stage, Mexidol is used in complex therapy.

The medication is administered intravenously and also intramuscularly for two weeks simultaneously with traditional therapy for the disease. It includes the use of nitrates, thrombolytics, beta-blockers, antiplatelet and anticoagulant drugs, angiotensin-converting enzyme inhibitors. At the same time, medications are prescribed according to indications, depending on the symptoms.

In the very first 4-5 days, in order to achieve maximum effect, Mexidol must be administered intravenously, after (another 9 days) it is allowed to be injected intramuscularly. The drug is delivered into the vein through a dropper, slowly (to prevent side effects). If necessary, jet injection is allowed (slow only). Injections are given strictly every 8 hours.

The daily therapeutic dose is 6-9 mg/kg of the patient’s body weight per day. Respectively single dose- three times less. The maximum dose allowed is 800 mg per day, and no more than 250 mg at a time.

Benefits of injection

Having carefully studied the instructions for using this wonderful drug, the patient will find there valuable information about possible complications due to self-prescription and use of injections of this drug. The drug Mexidol should be used only after receiving a qualified prescription from the attending physician, who will monitor changes in the dynamics of the clinical picture.

The advantage of the intravenous use of this medication is the rapid achievement of a therapeutic effect, since active substance immediately penetrates the blood. When administering the drug by drip, it is possible to retain the substance in its high concentration inside the bloodstream for an hour, or even longer.

Intramuscular injection of Mexidol has lower effectiveness, since the active component goes through several stages of metabolism. Accordingly, the effect of the medication will be somewhat weaker. Jet administration of the medicine is practically in no way inferior to dripping in terms of therapeutic properties.

Side effects

The digestive system is capable of reacting to the use of such a drug with the appearance of nausea, especially dry oral mucosa. Drowsiness and mild allergic reactions are possible.

The drug solution in the situation of parenteral administration is well tolerated by patients. Only sometimes nausea and some dry mouth are possible. Allergies during therapy are also possible. It is characterized by skin rash, itching, and urticaria (a special type of rash similar to when a person is burned by nettles).

Important! If you take the medication using excessive therapeutic doses, drowsiness develops. The appearance of additional side effects becomes a compelling reason to immediately stop taking the medication.

special instructions

Sometimes, especially among patients predisposed to attacks of bronchial asthma and having increased sulfite sensitivity, the development of dangerous reactions hypersensitivity.

When starting to use the injection solution, you should especially carefully study the instructions for the drug in order to understand why Mexidol injections are prescribed.

There are several fundamental guidelines regarding the use of the medicine, which you must pay close attention to:

• With increased sulfite sensitivity, diagnosing bronchial asthma, the drug can provoke a complex allergic reaction. It is expressed by angioedema complicated by Quincke's edema. This is the name given to severe swelling of the facial tissues and genitals. At the same time, there is a real danger of developing anaphylactic shock, which is a syndrome of pronounced reactive drop in systemic blood pressure.
• There is no verified information about the safety of the drug in relation to pregnant women, minor children, and mothers breastfeeding their newborn. Because of this, the use of the drug for the treatment of these categories of patients is not recommended. Only sometimes such a prescription is performed by the attending physician, when the expected dose of the active substance received does not exceed the existing risk of developing a dangerous disease.
• The solution for parenteral administration cannot be used in cases of observed functional renal or hepatic failure.
• The medication enhances the effectiveness of anticonvulsants (Carbamazepine), Benzodiazepine, as well as antiparkinsonian (Levodopa) drugs.
• After using the medicine, it is not recommended to perform any work that requires a person to increased speed psychomotor reactions and concentration due to possible drowsiness.

Pharmacy kiosks dispense a solution intended for parenteral use and only with a medical prescription. It is forbidden to use it independently when you do not have a doctor’s prescription.

Interaction with other drugs

Although the medicine reduces the toxic effect of ethyl alcohol, this does not at all mean a recommendation to actively drink alcohol, and then inject this drug to prevent Negative consequences drinking. The drug potentiates the activity of its derivatives: Levodopa, Carbamazepine and benzodiazepine.

Overdose

The only risk of overdose is the development of hypersomnia syndrome. This is dangerous if you need to drive a vehicle or perform actions that require special concentration and tension.

Analogues of Mexidol injections

The number of drug analogues is small, although they are produced. The drugs Medomex, Mexiprim and Mexipridol, Astrox and Armadin, as well as Mexicor are as close as possible in terms of therapeutic effects, as well as composition.

Terms and conditions of storage

A special feature of storing the medicine is the requirement that it be kept in a dry place, protected from exposure to light and accessible to small children.

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Intravenous administration of Mexidol in a single dose, which usually should not exceed 300 mg, causes a decrease in the threshold of the patient's limiting electrical sensitivity.

First of all, the drug has a positive effect on the optic nerves. Usually side symptom is the expansion of the total boundaries of vision. The decision to use Maxidol intravenously is made by doctors two weeks after the start of treatment. The effect of using the drug does not change blood flow in the arteries eyeball. Also, the drug does not have a negative effect on the eye orbits. They are transient, non-critical, and all consequences from the administration of this drug are leveled out 3 months after the end of therapy.

In this case, analogues perform much worse and their use is accompanied by a large number of side effects. The delayed vasotropic effect of Mexidol is associated with an increase in blood flow pressure in the central artery, which is directly connected to the retina. The maximum effect occurs 90 days after the infusion therapy ends.

The use of Mexidol intravenously is due to the patient’s acute condition, which occurs due to circulatory disorders or stroke. For these patient conditions, the drug is prescribed intravenously for a very short term, for more than 4 days. Then the treatment continues, but the drug is already administered intramuscularly. In this case, the dose is reduced to 100 mg.

The number of appointments varies individually, depending on changes in clinical parameters. The drug is also administered intravenously. Similar radiation methods are used to neutralize the effects of poisoning antipsychotic drugs or neuroleptics. For this diagnosis, the optimal dose is a maximum of 400 mg.

IN modern practice Doctors widely use intravenous Mexidol injections. At the same time, for any form of administration of the drug, both intramuscular and intravenous, the maximum daily dose should be no more than 1200 mg.

In addition to the main method of administering the drug, there is a second method - the jet method. It is also widely used in modern medical practice. The peculiarity of how Mexidol is administered in a stream is that it must be administered slowly, over 5-7 minutes. This is the optimal speed that is well accepted by patients.

The drug is administered intravenously, dissolving it with water for injection or with another very popular drug, saline sodium chloride solution. Under no circumstances should Mexidol be administered to patients under the influence of alcohol. Not in tablet form or in any other form.

And yet, most often doctors prefer to use IVs that are placed throughout the week. Intramuscular injections are allowed (in this case, the medicine is prescribed in ampoules), but due to their very painful tolerability, both patients and doctors most often refuse them. The most common solution is to administer the drug by drip. In this case, the administration interval is up to 60 drops per minute. Mexidol is administered slowly over 5-7 minutes.

In any case, it is highly not recommended to start using the drug on your own, even based on the data from Mexidol’s instructions. The doctor prescribes the drug based on indications for use and general clinical condition patient. Despite the fact that Mexidol is practically a panacea for many, you should be wary of this drug. This is far from a panacea.

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where it is better to give an injection of MEXIDOL IV or VM.

Mexidol is used intramuscularly or intravenously (stream or drip). The drug is recommended to be administered as a stream to relieve withdrawal symptoms and vegetative and sympathoadrenal paroxysms (a sharp increase in the concentration of adrenal hormones / adrenaline / in the blood), and as a drip for acute disorders cerebral circulation.

When administered intravenously, it is recommended to use sterile water for injection as a solvent. Mexidol is administered in a stream over 5-7 minutes, and dropwise at a rate of 60 drops per minute. Doses are prescribed individually.

Begin treatment with a dose of 100 mg 1-3 times a day, gradually increasing the dose until a therapeutic effect is obtained. The duration of treatment and the choice of individual dose depend on the severity of the patient’s condition and the effectiveness of treatment. The maximum daily dose should not exceed 800 mg.

For the treatment of acute cerebrovascular accident (stroke), Mexidol is prescribed intravenously by drip into the brain in the first 2-4 days, and then intramuscularly at a dose of 100 mg 3 times a day.

Patients with dyscirculatory encephalopathy and vegetative-vascular dystonia The drug is administered intramuscularly 3 times a day.

In case of withdrawal syndrome, Mexidol is administered intramuscularly 2-3 times a day or intravenously (drip) 1-2 times a day, and for neurotic and neurosis-like disorders it is prescribed intramuscularly in a dose daily.

For the treatment of atherosclerotic dementia in elderly patients, Mexidol is used intramuscularly up to a day.

In case of acute neuroleptic intoxication (poisoning with neuroleptics), the drug is used intravenously in a stream up to seven times a day.

Mexidol intramuscularly or intravenously, which is better?

The three injections listed above are the most common. Moreover, the most common ones are intramuscular injections. It is the simplicity and speed of these injections that allow many people to inject themselves and/or their loved ones at home.

At home, it is recommended to give intramuscular injections only in the buttock or thigh. It is not safe to inject into the deltoid muscle of the arm. In most cases, intramuscular injections are given by doctors, nurses and ambulance paramedics.

When a medicine is injected with a syringe into a vein, it is said to be jet(intravenous) administration of a drug.

There are situations when it is necessary to administer a large amount of medicine or when the effect of the medicine is better, if you inject it into a vein very slowly and it must be highly diluted. In the latter case we are already talking about infusion(when the patient needs to be given an IV). This drip(intravenous) administration medications to the patient (rate of administration of drops per minute).

The medicine was created by outstanding Russian scientists at the end of the last century and has no analogues abroad. The active substance Mexidol ethylmethylhydroxypyridine succinate is low toxic.

It is for this reason that Mexidol exhibits side effects only in isolated cases (dryness of the oral mucosa, nausea, allergies may occur in case of individual hypersensitivity to Mexidol or vitamin B6).

No severe side effects, in turn, expand the possibilities of using Mexidol in medical practice at high therapeutic effect drug.

All this, as well as the pharmacological properties of Mexidol - an antioxidant and antihypoxant - make it successful application in such areas of medicine as neurology, psychiatry, surgery, ophthalmology and dentistry.

Mexidol helps very well in the treatment of strokes and traumatic brain injuries, because stimulates blood flow to the brain, as well as the supply of oxygen and nutrients to the brain.

In both cases, Mexidol is administered intravenously, two to four times a day, two hundred to five hundred milligrams (two weeks).

Treatment of acute cerebrovascular accidents is completed with intramuscular injections of Mexidol two hundred to two hundred and fifty milligrams two to three times a day (two weeks).

Therapy dyscirculatory encephalopathy also finish with intramuscular injections of one hundred and two hundred and fifty milligrams per day (two weeks). Intramuscular injections of Mexidol, two hundred to two hundred fifty milligrams, twice a day are also given to prevent the above-mentioned encephalopathy (two weeks).

Unfortunately, older people often have problems with attention, memory, etc. (as a consequence of atherosclerosis). In the treatment of such mild disorders (in medicine they are designated "cognitive disorders") intramuscular injections of Mexidol, which are given daily at one hundred to three hundred milligrams (from two to four weeks), help very well.

Similar therapy helps very well in the case of neurotic states(anxiety, fear, etc.). Patients' anxiety goes away, performance and sleep normalize.

Intramuscular or intravenous injections of Mexidol are used successfully in complex treatment acute myocardial infarction(together with medications that are traditionally used to treat this dangerous disease).

Both jet injections into a vein and drip infusions of one hundred to one hundred and fifty milliliters of Mexidol solution are allowed.

Mexidol injections also successfully help in treatment:

in the treatment of hypertension (reduce blood pressure)

A difficult and at the same time very urgent problem is the problem of treating alcoholism. dependencies.

Mexidol injections are successfully used to relieve withdrawal symptoms, when vegetative-vascular neurosis and other neurosis-like conditions predominate.

In this case, you can give intravenous or intramuscular injections:

From five to seven days they give Mexidol injections of two hundred to five hundred milligrams (daily).

There are also contraindications for Mexodil injections.

These are patients with serious illness liver and kidneys, patients with bronchial asthma who have increased sensitivity to sulfites.

Mexidol injections are not prescribed pregnant and lactating mothers.

2 comments:

Hello! I have hearing loss and heart failure, I constantly have a headache, when I was constantly at the ENT, she constantly prescribed me the medicine Mexidol Cavinton Mildronate, because I felt good and advised me to take Cavinton drops twice a year and the rest were injections into a vein, but since she had problems and she no longer works at all, I turned to a nurse who constantly did things for me as prescribed by the doctor and I asked her to do everything the same as they did without a doctor’s prescription, she denies she can’t do it without a direction, she categorically refuses, now I want to consult with you I have someone who does it into a vein at home, but she doesn’t know what to dilute Mexidol with or saline solution or with novocaine, why am I in a hurry because a lot of time has passed since I didn’t take the drops in the spring and it’s already summer, instead of these medications I took piracetam intramuscularly at home so that I can give a little support, but I can’t anymore because it doesn’t hurt much, but I’ll practically say that almost every day I have a headache, my heart, or my blood pressure, so I beg you, please advise what to dilute Mexidol Cavinton with, how much is needed and how and if possible, a video of how to do it in a vein? Thank you in advance!

Hello, Nastya! Sorry for the late answer to your question. However, we hope that you found the necessary information on our website in the instructions for Mexidol http://www.meksidol-info.ru/2013/06/meksidol-instrukcija.html:

"For infusions, Mexidol is diluted in a 0.9% solution of sodium chloride (in two hundred ml of NaCl) or a 5% solution of dextrose (glucose). Stream or drip injections are carried out."

Mexidol

Description current as of 09/04/2014

• Latin name: Mexidolum
• ATX code: N07XX
• Active ingredient: Ethylmethylhydroxypyridine succinate (Aethylmethylhydroxypyridini succinas)
• Manufacturer: Ellara LLC, Armavir Biofactory, Moscow Endocrine Plant, Mir-Pharm, ZiO-Zdorovye, ALSI Pharma (Russia)

Compound

The composition of the drug in the form of an injection solution includes ethylmethylhydroxypyridine succinate as an active substance (50 mg per 1 ml) and auxiliary components:

One Mexidol tablet contains 125 mg of the active ingredient ethylmethylhydroxypyridine succinate, as well as a number of auxiliary components:

• lactose monohydrate;
• sodium carboxymethylcellulose (sodium carmellose);
• magnesium stearate.

Each tablet is coated with a white or creamy white film consisting of:

• Opadry II white (macrogol polyethylene glycol);
• polyvinyl alcohol;
• talc;
• titanium dioxide.

Release form

The drug Mexidol has two forms of release: in ampoules and in tablets.

Mexidol in ampoules is intended for infusions and intramuscular injections. The solution is produced in ampoules made of colorless or light-protected glass, on which the breaking point is marked in blue or white and three marking rings, the top of which is yellow, the middle - white, the bottom - red.

Ampoules have a capacity of 2 or 5 ml and are packaged in 5 pieces in blister packs. The cardboard packaging is completed with 1 or 2 contour packages, as well as instructions for medical use drug.

For hospital inpatient units, Mexidol solution is packaged in 4, 10 or 20 blister packs.

One tablet of Mexidol weighs 125 mg and is intended for oral administration. Tablets are produced packaged in 10 pieces in blister packs made of PVC film and aluminum foil or 90 pieces in plastic jars made of food grade plastic.

For inpatient medical institutions, tablets are produced in plastic jars made from food-grade plastic, 450 or 900 pieces each.

Description of the drug in the form of a solution for injection

Mexidol in ampoules has the form of a clear liquid, which can be either colorless or slightly yellowish.

Description of the tablet form of Mexidol

The tablets are biconvex, round in shape, coated, the color of which can vary from white to white with a slightly creamy tint.

pharmachologic effect

The medicine Mexidol belongs to the pharmacological group of drugs that affect the nervous system.

In addition, it has a pronounced stress-protective effect (that is, it increases the body’s resistance to stress), improves memory, has the ability to prevent or stop seizures, and also reduces the concentrations of certain lipid fractions (in particular, low-density lipoproteins) in various tissues and body fluids.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The pharmacological properties of Mexidol are determined by the activity of ethylmethylhydroxypyridine succinate, which is part of it.

According to Wikipedia, this substance belongs to the category of drugs that prevent or slow down the processes of peroxidation of membrane lipids in cells.

Ethylmethylhydroxypyridine succinate belongs to the class of 3-hydroxypyridines and is a pyridine derivative general formula C5H4_nN(OH)n.

The substance has the form of colorless crystals, which are characterized by the ability to easily dissolve in ethanol and acetone, moderately dissolve in water and limitedly in diethyl ether, benzene and ligroin.

The mechanism of action of ethylmethylhydroxypyridine succinate is determined by its antioxidant and membrane protective properties.

Acting as an antioxidant, it slows down and suppresses oxidative chain reactions in which active free radicals, represented by peroxide (RO2*), alkoxy (RO*) and alkyl (R*) forms of oxygen, take part.

Thanks to this, against the background of using Mexidol:

• the activity of the antioxidant enzyme superoxide dismutase (SOD) increases;
• the ratio of proteins and lipids increases;
• The viscosity of cell membranes decreases and, accordingly, their fluidity increases.

The drug regulates and normalizes the activity of membrane-bound enzymes (in particular, the main enzyme of the cholinergic system acetylcholinesterase, the enzyme of the lyase class of adenylate cyclase and calcium-independent PDE (phosphodiesterase)), as well as the activity of receptor complexes (for example, the GABA-benzodiazepine receptor complex).

• membrane-binding enzymes and receptor complexes increase their ability to bind ligands;
• normal indicators of the structural and functional organization of biological membranes are maintained;
• the processes of transport of neurotransmitters are normalized;
• indicators of synaptic transmission of neurotransmitters improve.

Mexidol tablets and injections can increase the body's resistance to the influence of various aggressive factors and pathological conditions associated with oxygen deficiency.

The drug effectively eliminates symptoms caused by oxygen deprivation, state of shock, ischemia, cerebral circulatory disorders, as well as symptoms of general poisoning of the body with drugs (in particular, antipsychotic drugs) or alcohol.

After a course of treatment with Mexidol (intravenously, intramuscularly or orally):

• the content of dopamine in the brain increases;
• the course of metabolic processes in the brain is normalized;
• cerebral blood supply is normalized;
• blood microcirculation improves;
• blood rheological parameters improve;
• platelet aggregation decreases;
• membranes of postcellular blood structures (erythrocytes and platelets) are stabilized during hemolysis;
• total cholesterol levels decrease;
• LDL levels decrease;
• the severity of symptoms of pancreatogenic toxemia (general blood poisoning) decreases;
• the severity of the syndrome of endogenous intoxication caused by acute pancreatitis;
• the compensatory activity of aerobic glycolysis increases;
• under conditions of oxygen starvation, the degree of inhibition of oxidative processes in the tricarboxylic acid cycle (Krebs cycle) decreases;
• the content of adenosine triphosphate (ATP) and creatine phosphoric acid (creatine phosphate) increases;
• energy synthesis by cellular mitochondria is activated;
• cell membranes are stabilized;
• the course of metabolic processes in the areas of the myocardium affected by ischemia is normalized;
• the area of ​​the necrosis zone decreases;
• the electrical activity of the heart and its contractility are restored and improved (in patients with reversible cardiac dysfunction);
• blood flow increases in areas of the myocardium affected by ischemia;
• the severity of the consequences of reperfusion syndrome caused by acute coronary insufficiency decreases.

Treatment with Mexidol IV or IM allows preserving ganglion cells, as well as nerve fibers of sensitive cells of the retina of the eye in patients with progressive forms of neuropathy caused by ischemic disease and hypoxia.

At the same time, patients experience a significant increase in the functional activity of the retina and optic nerve, and visual acuity increases.

The anti-stress effect of treatment with Mexidol tablets is expressed as:

• normalization of behavior after suffering stress;
• disappearance of symptoms of somatovegetative disorders;
• normalization of sleep and wake cycles;
• restoration (partial or complete) of impaired learning abilities;
• memory restoration;
• reducing the severity of dystrophic and morphological changes in various parts of the brain.

Mexidol is also a remedy that effectively eliminates the symptoms that occur during withdrawal states.

It relieves manifestations of intoxication caused by alcohol withdrawal (both neurological and neurotoxic), restores behavioral disorders, normalizes autonomic functions, relieves or reduces the severity of cognitive impairment caused by prolonged alcohol consumption or abrupt cessation of alcohol.

Pharmacokinetics

After intramuscular injection, the active substance Mexidol is determined in the blood plasma for another four hours. The time during which maximum plasma concentration is achieved ranges from 0.45 to 0.5 hours.

Mexidol is quickly absorbed from the bloodstream into various tissues and organs and is just as quickly eliminated from the body: the average retention time of ethylmethylhydroxypyridine succinate varies from 0.7 to 1.3 hours.

Biotransformation of ethylmethylhydroxypyridine succinate occurs in the liver. As a result, phosphate-3-hydroxypyridine, glucurone conjugates and other metabolic products are formed. Moreover, some of them are characterized by pharmacological activity.

The drug is excreted primarily in the urine and mainly in glucuron-conjugated form. A small amount of it is excreted unchanged.

According to the annotation for Mexidol, there are no significant differences in the pharmacokinetic profiles of ethylmethylhydroxypyridine succinate when taking a single dose and undergoing a course of treatment.

After oral administration of Mexidol ethylmethylhydroxypyridine succinate tablets, it is quickly absorbed, quickly distributed in various tissues and organs, and quickly eliminated from the body.

After 4.9 to 5.2 hours after taking the tablet, its active substance is no longer detectable in the patient’s blood plasma.

After biotransformation in the liver through conjugation with glucuronic acid, five metabolites are formed. In particular, phosphate-3-hydroxypyridine, which is then broken down by alkaline phosphatase into 3-hydroxypyridine and phosphoric acid.

In addition, a pharmacologically active substance is formed in large quantities, which is determined in the patient’s urine even hours after taking the drug, two glucuron conjugates and a substance that is excreted from the body in large quantities in the urine.

The half-life of Mexidol after oral administration varies from 2 to 2.6 hours.

The substance is excreted mainly in the urine in the form of metabolites (this process is especially intense in the first four hours after administration) and only a small part of it is excreted unchanged.

Excretion rates in urine of the drug in unchanged form and in the form of metabolic products are characterized by individual variability.

Indications for use of Mexidol

Indications for the use of Mexidol injections (intravenously or intramuscularly):

• acute circulatory disorders in the brain;
• traumatic brain injuries (injections of the drug are also prescribed to relieve or reduce the severity of the consequences of traumatic brain injuries);
• slowly progressive insufficiency of cerebral blood supply (dyscirculatory encephalopathy);
• neurocirculatory (vegetative-vascular) dystonia syndrome;
• mild forms of cognitive dysfunction of atherosclerotic origin;
• anxiety disorders that accompany neurotic and neurosis-like (pseudo-neurotic) conditions;
• acute myocardial infarction (the drug is prescribed from the first days in the form of droppers or intramuscular injections as part of a complex of therapeutic measures);
• open-angle glaucoma of the primary type (Mexidol in ampoules is intended for the treatment of the disease at various stages, complex therapy is considered the most effective);
• alcohol withdrawal syndrome, characterized by a predominance of pseudoneurotic and vegetative-vascular disorders;
• symptoms of intoxication of the body with antipsychotic drugs;
• purulent-inflammatory processes occurring in an acute form in the abdominal cavity (including necrotizing pancreatitis or peritonitis; the drug is prescribed as part of a complex of therapeutic measures).

Indications for the use of Mexidol tablets:

• consequences of acute circulatory disorders in the brain, including the consequences of TIA (transient ischemic attack), as well as as a prophylactic agent at the stage of decompensation of diseases caused by cerebral circulatory disorders;
• minor traumatic brain injuries and their consequences;
• non-inflammatory brain diseases (encephalopathies) of various origins (for example, dyscirculatory or post-traumatic);
• anxiety disorders that accompany neurotic and pseudoneurotic conditions;
• ischemic disease (as part of a complex of therapeutic measures);
• alcohol withdrawal syndrome, manifested mainly in the form of pseudoneurotic, vegetative-vascular and post-abstinence disorders;
• symptoms of antipsychotic drug poisoning;
• asthenic syndrome.

Also, an indication for the use of the drug in tablet form is the presence of a sympomocomplex in the patient, caused by the impact of stress factors on the body.

In addition, for preventive purposes, Mexidol is indicated for patients who have a high risk of developing somatic diseases due to exposure to extreme factors and stress.

The mechanism of action of Mexidol is determined by its antihypoxic, antioxidant and membrane protective properties. Therefore, to the questions “What are Mexidol tablets for?” and “When is Mexidol solution effective?”, experts answer that prescribing the drug is considered the most appropriate and successful for:

Contraindications for Mexidol

Contraindications to the use of the drug are:

• hypersensitivity to ethylmethylhydroxypyridine succinate or any of the auxiliary components;
• acute liver failure;
• acute renal failure.

Side effects of Mexidol

The drug is well tolerated and quite rarely provokes certain undesirable effects.

Side effects, which in some cases may occur after taking Mexidol in solution form:

Side effects that are potentially possible after taking Mexidol tablets include:

Also, the drug sometimes increases or decreases blood pressure, provokes emotional reactivity, distal hyperhidrosis, impaired coordination and the process of falling asleep.

Instructions for use of Mexidol: method and dosage

Mexidol injections, instructions for use. How to administer intramuscularly and intravenously

The drug in the form of an injection solution is intended for administration intramuscularly or into a vein (by jet or drip infusion). If Mexidol is prescribed for intravenous administration, the contents of the ampoule should be diluted in an isotonic sodium chloride solution.

A jet infusion involves administering a solution over five to seven minutes; the drug is administered by drip at a rate of forty to sixty drops per minute. In this case, the maximum permissible dose should not exceed 1200 mg per day.

Before injecting intramuscularly or administering the drug intravenously, you should read the instructions. The optimal dosage of Mexidol in ampoules is selected individually in each specific case, depending on the patient’s diagnosis and the nature of the course of his disease.

Dosing of Mexidol in solution form

Acute cerebral circulatory disorders: from 200 to 500 mg by drip into a vein two to four times a day for days.

Next, the drug should be administered intramuscularly. As indicated in the instructions, this method of treatment is the most effective. The solution is administered intramuscularly for two weeks, two or once a day, at a dose of 200 to 250 mg.

Elimination of the consequences of traumatic brain injuries: the drug is administered by drip in a dose of 200 to 500 mg. The frequency of administrations is from 2 to 4, the duration of treatment is from 10 to 15 days.

Slowly progressive insufficiency of cerebral blood supply at the stage of decompensation: the drug is administered by drop or jet method once or twice a day for two weeks.

The dose is selected individually and varies from 200 to 500 mg. Further treatment involves the appointment of intramuscular injections: over the next 14 days, the patient is administered from 100 to 250 mg of Mexidol per day.

As a prophylactic against discirculatory encephalopathy: the drug is prescribed for injection into the muscle, the daily dose is from 400 to 500 mg, the frequency of administration is 2, the duration of the therapeutic course is two weeks.

Mild cognitive impairment in elderly patients and anxiety disorders: the solution is injected into the muscle, the daily dose varies from 100 to 300 mg, the duration of the therapeutic course is from two weeks to one month.

Acute myocardial infarction (in combination with other therapeutic measures): the medicine is injected into a muscle or vein over two weeks in combination with traditional measures taken to treat patients with myocardial infarction.

In the first five days of the therapeutic course, it is recommended to administer the drug intravenously by drip infusion, then you can switch to intramuscular injections (injections continue to be given for nine days).

When administered by infusion, Mexidol is diluted in an isotonic solution of sodium chloride or in a 5% glucose solution. The recommended volume is from 100 to 150 ml, the infusion time can vary from half an hour to an hour and a half.

In cases where this is necessary, the solution can be administered by drip (the duration of the infusion should be at least five minutes).

Both intravenously and intramuscularly, the drug should be administered three times a day with an interval of eight hours. The optimal dose is from 6 to 9 mg per day per kilogram of the patient’s body weight. Accordingly, a single dose is 2 or 3 mg per kilogram of body weight.

In this case, the maximum permissible daily dose should not exceed 800 mg, and a single dose should not exceed 800 mg.

Open-angle glaucoma (for various stages of the disease in combination with other therapeutic measures): the drug is administered intramuscularly for two weeks, the daily dose varies from 100 to 300 mg, the frequency of injections is from 1 to 3 during the day.

Alcohol withdrawal: method of administration - drip infusion or intramuscular injections, daily dose varies from 200 to 500 mg, frequency of injections - 2 or 3 per day. The duration of the therapeutic course is from 5 to 7 days.

Intoxication with antipsychotic drugs: route of administration - intravenously, daily dose - from 200 to 500 mg, duration of the therapeutic course - from one to two weeks.

Acute purulent inflammatory processes of the abdominal cavity: the drug is indicated for use both on the first day before surgery and on the first day after the operation. Method of administration: intravenous drip and intramuscular injection.

The dose is selected depending on the severity and form of the disease, the extent of the lesion, and the characteristics of the clinical picture. It varies from 300 (for mild necrotizing pancreatitis) to 800 mg (for severe severe course diseases) per day.

Discontinuation of the drug should be carried out gradually and only after achieving a stable positive clinical and laboratory effect.

Mexidol tablets, instructions for use

Mexidol tablets are intended for oral administration. The daily dose varies from 375 to 750 mg, the frequency of doses is 3 (one or two tablets three times a day). The maximum permissible dose is mg per day, which corresponds to 6 tablets.

The duration of treatment depends on the disease and the patient’s body’s response to the prescribed treatment. As a rule, it ranges from two weeks to one and a half months. In cases where the drug is prescribed to relieve symptoms of alcohol withdrawal, the duration of the course is from five to seven days.

In this case, abrupt discontinuation of the drug is unacceptable: treatment is stopped gradually, reducing the dose over two to three days.

At the beginning of the course, the patient is prescribed to take one or two tablets per dose, once or twice a day. The dose is gradually increased until a positive clinical effect is obtained (it should not exceed 6 tablets per day).

The duration of the therapeutic course in patients diagnosed with ischemic disease is from one and a half to two months. If necessary, a second course may be prescribed as prescribed by a doctor. Optimal time for appointment of a repeated course - autumn and spring.

Overdose

The instructions warn that a medicine such as Mexidol, if the recommended dose is exceeded, can provoke the development of drowsiness.

Interaction

The drug is compatible with all drugs that are used to treat somatic diseases.

When used simultaneously with benzodiazepine derivatives, antidepressant, neuroleptic, tranquilizing, anticonvulsant (for example, carbamazepine) and antiparkinsonian (levodopa) drugs, their effect on the body increases.

This allows you to significantly reduce the doses of the latter, as well as reduce the likelihood of the development and severity of unwanted side effects (which is why Mexidol is prescribed to certain categories of patients).

The drug reduces the severity of the toxic effects of ethanol.

Mexidol and Piracetam: compatibility

Piracetam as an active component is included in the drug Nootropil, which is used to improve cognitive processes of the brain.

The combined administration of Nootropil and Mexidol allows one to achieve better results in increasing mental abilities in children, restoring patients after an ischemic stroke or coma, treating chronic alcoholism, psycho-organic syndrome (including in elderly patients with reduced memory, mood lability, behavioral disorders) etc..

It should be noted, however, that in contrast to nootropic drugs (and, in particular, Nootropil), Mexidol does not have an activating effect on the body, does not provoke sleep disturbances or increased convulsive activity.

In terms of its therapeutic effectiveness, it is significantly superior to Piracetam.

Compatibility of Mexidol and Actovegin

Mexidol and Actovegin have a similar mechanism of action, so they are often prescribed in combination with each other. However, since Actovegin is made from calf blood, it is somewhat more likely than Mexidol to provoke certain side effects.

Actovegin at the molecular level accelerates the processes of utilization of oxygen and glucose, thereby increasing the body's resistance to hypoxic conditions and helping to increase energy metabolism.

Compatibility of Cavinton and Mexidol

The active component of Cavinton is Vinpocetine, which is synthesized from vincamine, an alkaloid of the perennial plant Vinca minor. The substance has the ability to dilate blood vessels, improve blood circulation in the brain, and has a pronounced antiaggregation and antihypoxic effect.

In addition, Vinpocetine is able to influence metabolic processes occurring in brain tissue and reduces platelet aggregation (or, in other words, sticking together), thereby improving its rheological properties.

Terms of sale

The drug is classified as a prescription drug.

Storage conditions

Mexidol should be stored in a dry place, protected from light and out of reach of children, at a temperature of no more than 25°C.

Best before date

Mexidol tablets and solution are suitable for use for 3 years. After the expiration of the period indicated on the packaging, their use is prohibited.

special instructions

Solution for intramuscular and intravenous administration

In patients with a predisposition to allergic reactions, hypersensitivity to sulfites, as well as in people with bronchial asthma, severe hypersensitivity reactions may develop during treatment.

Mexidol tablets

During the course of treatment with Mexidol tablets, special care should be taken when driving and performing work that poses a danger to health and life. This is due to the fact that the drug has the ability to slow down the speed of psychomotor reactions and reduce concentration.

Mexidol's analogs

Many patients often have the question “What can replace the drug prescribed by a doctor and are there cheaper analogues?”

Analogs of Mexidol in tablets:

Analogues of the drug in ampoules are:

Quite often, patients have a question: which analogue of the drug prescribed to them is better, cheaper, has fewer side effects, etc. Therefore, it is worth considering this topic in detail.

Which is better: Actovegin or Mexidol?

The drugs are used in similar areas of medicine. For this reason, to achieve a more pronounced clinical effect, patients are prescribed them in combination.

Which is better: Cavinton or Mexidol?

Both Cavinton and Mexidol are complementary drugs, so they are often prescribed in combination to eliminate the consequences of circulatory disorders in the brain.

The main requirement is that the drugs should not be mixed in the same dropper or in the same syringe.

Which is better: Mexidol or Mexicor?

Mexicor is a generic (synonym) of Mexidol. Therefore, the drug is used in the same areas of medicine as Mexidol. It is available in the form of gelatin capsules, tablets and solution for injection.

Mexicor effectively relieves anxiety, relieves fears and improves mood, improves memory, attention, increases performance and learning abilities, eliminates symptoms of alcohol intoxication and reduces the pathological consequences of a stroke.

The drug belongs to the group of metabolic cardiocytoprotectors. The mechanism of its action is due to the fusion in its composition of the antihypoxant succinate and the antioxidant emoxypine, which is characterized by a wide spectrum of action.

In combination with other therapeutic measures, Mexicor is indicated for the treatment of myocardial ischemia and ischemic stroke. It is also recommended to be prescribed in the treatment of mild and moderately severe cognitive disorders and to reduce the severity of symptoms of dyscirculatory encephalopathy.

Mexiprim and Mexidol - which is better?

Mexiprim is the German analogue of Mexidol. Its manufacturer is STADA Arzneimittel AG. The main difference between the drugs is the composition of the auxiliary components of the core and shell of the tablets. Their mechanism of action and indications for use are similar.

Mexidol or Mildronate - which is better?

Mildronate belongs to the group of drugs that improve metabolism and energy supply to tissues. It is available in the form of gelatin capsules, solution for injection and syrup for oral administration.

The active ingredient of the drug is meldonium (trimethylhydrazinium propionate), which is similar in structure to gamma-butyrobetaine (a substance present in every cell of a living organism).

Mildronate is used as a vasodilator. In addition, the drug improves the supply of oxygen to organs and tissues, helps increase humoral and tissue immunity, and reduces blood pressure.

Mexidol and Mildronate, according to the doctor’s decision, can be prescribed as part of combination therapy to treat patients with:

Synonyms

• film-coated tablets and solution for intravenous and intramuscular administration of Medomexi;
• solution for intravenous and intramuscular administration Mexidant;
• film-coated tablets and solution for intravenous and intramuscular administration of Mexiprim;
• Mexifin injection solution and tablets;
• solution for intravenous and intramuscular administration Neurox;
• Mexipridor injection solution and tablets;
• solution for intravenous and intramuscular administration and Mexicor capsules.

Prescription of the drug Mexidol for children

The drug is not prescribed to children and adolescents due to insufficient knowledge of the effect of ethylmethylhydroxypyridine succinate on the children's body.

Mexidol and alcohol

Mexidol is a drug that has a powerful antioxidant effect. For this reason, it is widely used in a wide variety of branches of medicine, including surgery, psychiatry, neurology, etc.

To the question “What is the medicine Mexidol for?” an experienced specialist will answer that the latter effectively restores the function of the neurological and psychological sphere and, in addition, helps to renew and maintain the functional activity of liver cells.

Due to the ability of the drug to have a hepatoprotective and nootropic effect, the prescription of Mexidol is one of the most common methods of treating alcohol withdrawal syndrome, which develops against the background of intoxication of the body with ethyl alcohol.

It is believed that Mexidol and alcohol are compatible. Some are inclined to believe that the drug even partially neutralizes the effect of the latter. However, this opinion is erroneous, since the active substance Mexidol, penetrating into the tissues of the brain and liver, only relieves existing symptoms of intoxication and eliminates pathology, but does not protect cells.

That is, the drug does not prevent the occurrence of unwanted symptoms of alcohol intake, but only eliminates its consequences:

• reduces the severity of headaches;
• reduces the severity of symptoms of intoxication;
• accelerates the process of removing toxic substances and fusel oils contained in alcohol from the liver.

However, Mexidol cannot protect against liver cirrhosis or irreversible mental disorders, if a person continues to drink alcohol in the same doses.

Mexidol during pregnancy and lactation

Pregnancy and lactation are contraindications to the use of Mexidol. This is due to the fact that strictly controlled studies of the effect of the drug on pregnant and lactating women have not been conducted.

How long therapy will last depends on what disease is being treated. So:

• to normalize the blood supply to the brain, Mexidol is used for 10 to 14 days;
• for atherosclerosis, injections will have to be given for 30 or even 40 days;
• for encephalopathy, the course of treatment is shorter - usually two weeks is enough;
• in case of necrotizing pancreatitis, the task of Mexidol is to reduce the severity of manifestations. In every individual case timing varies;
• It may take 7-10 days to eliminate intoxication with antipsychotics.

In any case, you should not stop treatment suddenly. In order not to cause discomfort, the dose should be reduced gradually.

Features of the drug

The drug relaxes muscle tissue well, prevents cells from oxidizing, stimulates blood circulation and removes harmful substances from the body. Many doctors note its sedative effect and the ability to have a beneficial effect on the human autonomic system. Such results are achieved due to the main active ingredient (ethylmethylhydroxypyridine succinate), which has a positive effect on the outer membrane of cells. Due to this effect, accelerated synthesis of dopamine occurs in the patient’s brain. It is a special neurotransmitter that can lift your mood and increase your ability to work.

The scientists who created this medicine claim that the list of things that Mexidol helps with includes its effect on hematopoiesis and the blood flow itself. This effect will be especially appreciated by people suffering from poor vascular permeability, anemia and high level cholesterol in the blood.

A sedative effect on the nervous system helps patients who suffer from panic attacks, anxiety, depression and other mental disorders.

Mexidol injections quickly stop such manifestations. After completing the course of injections, there are no negative consequences, such as addiction.

You can inject during a stroke, as it helps improve cerebral (brain) blood circulation and serves prophylactic from relapses. Among its other advantages, we can highlight its good compatibility with most well-known medications. That is why Mexidol is used in many treatment regimens as a primary or additional treatment.

Question answer

• Question- Hello, Doctor! Over the past week I have been feeling dizzy very often. I saw a neurologist, did an REG, they said some things were normal, some were not, and they also found osteochondrosis. For treatment, Mexidol was prescribed once a day, Cavinton 3 times a day and Bellataminal half a tablet 2 times a day. I didn’t see any results after the treatment, I still feel dizzy. Please tell me what to do? What other examinations can be carried out? Sincerely, Natalia. Answer- Hello, Natalia! You definitely need to consult a competent neurologist and ENT doctor; it is best to even consult an otoneurologist. Instrumental examinations depend only on the results of a study of the neurological status and otoneurological examination;
• Question- Hello! I am 34 years old. A month ago I started having a constant headache. I turned to a neurologist for help. After doing a tomography, the doctor said that the vertebra on which the head rests prevents normal blood circulation to the brain, in addition, there is also an excess of fluid that washes the brain. For treatment, I was prescribed Mexidol, Omaron and Neuromultivit. The doctor said that first you need to inject Mexidol, and only then drink Omaron. However, he didn’t say anything about Neuromultivit. Please tell me when can I start drinking Neuromultivit, and is it worth drinking it at all? Answer- Hello! The doctor prescribed you neuromultivitis as a strengthening drug after the administration of Mexidol. Neuromultivitis is vitamins B (B1, B6, B12), which are not enough for normal functioning central nervous system. It is impossible to explain your situation specifically, since you need to familiarize yourself with tomography tests and medical history. For your safety, we recommend that you make an appointment with a more qualified neurologist or even seek help from a neurosurgeon.

Video: consultation from a doctor about the drug Mexidol

Mexidol injections

Mexidol is sold not only in tablet form, but also in injection ampoules. In ampoules, the medicine is administered intravenously by drip or jet method. With the drip version of treatment, the ampoule with Mexidol must be diluted with saline and administered at a rate of 60 drops per minute, with the jet method - very slowly and undiluted. The maximum dose per day is 1200 mg. In the first 2 weeks after a stroke, Mexidol in ampoules should be administered 200-500 mg 4 times a day, and then the same dosage, but twice a day. This medicine will help in the complex treatment of arthritis and pancreatitis, although it will not be the main drug.

Mexidol indications for use

This synthetic antioxidant is suitable for internal use. It is produced as a liquid solution for injection and in the form of pills. If the doctor has prescribed Mexidol, the indications for use should be discussed in advance, cases of overdose and contraindications should be excluded. In case of drug incompatibility, it is worth choosing a more gentle analogue with a mild effect on the site of pathology.

Active substance chemical formula– ethylmethylhydroxypyridine succinate. The synthetic component improves tissue respiration, which is especially important for all types of hypoxia. In addition, it provides high-quality nutrition to tissues and effectively fights the products of intoxication in the body. The therapeutic effect is almost instantaneous, especially if these are intramuscular injections for shock conditions.

Interaction

The medication Mexidol is used in combination with various medications used to treat various somatic diseases.

When administered simultaneously with benzodiazepine derivatives, antidepressants, tranquilizers, and anticonvulsants, their effect on the human body increases.

The medication helps to significantly reduce the toxicity of ethanol. Mexidol together with Nootropil allows you to quickly achieve the desired improvements in increasing mental performance in children.

The parallel use of Medoxidol with Actovegin allows you to accelerate the processes of utilization of oxygen and glucose, which significantly increases metabolism and the body’s resistance to insufficient oxygen.

With alcohol

Mexidol has an antioxidant effect and is widely used in various medical fields. The medicine also has a beneficial effect on the liver and also increases the functionality of the brain, so it is often prescribed for the treatment of alcohol withdrawal syndrome, which appears as a result of intoxication of the body with ethanol.

It is generally accepted that the medication Mexidol helps neutralize the effects of alcohol on the body, but this is not entirely true. The elements that are components of the drug invade the tissues of the brain and liver, help eliminate the symptoms resulting from the state of poisoning of the body and eliminate pathological processes without protecting the cells.

Based on this, the remedy cannot prevent the occurrence of symptoms of drinking alcoholic beverages, but it saves from the consequences.

Drug interactions

Quite often, Mexidol is one of the components of the treatment process and is used in parallel with other medications. The dose and duration of use of Mexidol often depend on how they interact.

In combination with it, the human body is more strongly influenced by:

• anticonvulsants;
• antidepressants;
• nootropics;
• neuroleptics;
• tranquilizers;
• benzodiazepine derivatives;
• painkillers.

In general, it can be noted that there were no negative results associated with the combination of Mexidol with any other medicine. But you should tell your doctor when you are taking any other medications at the same time.

Compound

The active ingredient of Mexidol is ethylmethylhydroxypyridine succinate (2-ethyl-6-methyl-3-hydroxypyridine succinate). An injection solution (50 g/l) or tablets containing 125 mg are available. active substance. This is a domestic drug and is one of the new generation of antioxidant drugs.

As excipients, the Mexidol injection solution includes sodium metabisulfite (1 g) and injection water (up to 1 liter). Mexidol tablets - excipients are magnesium stearate, sodium carboxymethylcellulose (otherwise known as carmellose), lactose monohydrate, as well as the components that make up the tablet shell - talc, macrogol, polyvinyl alcohol and titanium dioxide.

Interaction of the drug with other drugs, Mexidol analogues

Instructions for the use of injections describe the enhancement of the therapeutic effects of drugs from the benzodiazepine group, Levodopa (for Parkinson's disease) and drugs that relieve seizures (Carbamazepine). Mexidol reduces intoxication in case of alcohol poisoning, as it reduces the concentration of formaldehydes in the blood formed as a result of the fermentation of ethyl alcohol (using injections of the medicine reduces the intensity of headaches, nausea and vomiting go away).

Analogs of the drug are Mexiprim, Mexicor, Mexidant, Mexifin, Cerecard, Neurox, Medomex (also used by injection).

Mechanism of action of the drug

Mexidol is a drug exhibiting antioxidant properties.

Mexidol tablets and injections, as indicated in the instructions for use, help inhibit free radical processes and lipid peroxidation.

With his help The antioxidant enzyme superoxide dismutase is activated. It has a positive effect on the physicochemical properties of the biomembrane.

During its effect on the human body, this drug acts as a substance that protects membranes, prevents the occurrence of seizures, increases the body’s resistance to the effects of negative factors and prevents the development of oxygen-dependent pathological conditions.

Mexidol improves the flow of processes in the brain, improves blood circulation and reduces the ability of platelets to attract each other. It helps reduce cholesterol levels.

Under the influence of this drug, the process of lipid peroxidation slows down, superoxide dismutase activity increases, the viscosity of the membrane decreases and, in turn, its fluidity decreases.

Due to its mechanisms of action, it has few contraindications and has a low level of toxicity.

Compatibility of Mexidol with alcohol

A special feature of the drug is its positive effect on the body during withdrawal symptoms. That is why it is prescribed for the treatment of alcoholism, in order to eliminate unpleasant symptoms during therapy.

The medicine reduces the severity of such symptoms:

• rapid pulse;
• headache;
• digestive problems;
• swelling of tissues;
• trembling in the limbs.

The medicine is most often prescribed intravenously. Droppers are placed so that the active substance enters the blood faster. It removes toxins that poison the body and helps the liver cope with increased load.

You should take the drug only after stopping alcohol! Concomitant use with alcohol-containing drinks will only worsen the condition.

Side effects

All groups of medications have certain side effects. In most cases, they are the result of an incorrectly selected dosage, intolerance to the composition, or an incorrect combination of medications. After an injection with Mexidol solution, the following undesirable reactions most often occur:

• Nausea to the point of vomiting;
• Manifestation of allergies;
• General weakness;
• Disturbed sleep rhythm;
• Dry mouth;
• Low work capacity.

The tablet form has the same side effects, but you can also add a negative effect on the gastrointestinal tract:

• Bloating and stomach cramps;
• Heartburn;
• Diarrhea or diarrhea.

In rare cases, after consuming Mexidol, blood pressure decreases and sweating increases, especially in the palms and feet. Against this background, the patient may experience sudden mood changes. However, all negative effects from taking this drug quickly disappear after its discontinuation.

Mexidol ampoules instructions for use

The product is also available in 5% ampoules in clear or dark glass. Depending on the dosage and other indicators, Mexidol 2 is divided ( 2 ml), Mexidol 5 ( 5 ml), Mexidol 10 (10 ml). It remains to consider what is it prescribed for? application this drug. The product is used for injections; specific dosages must be chosen strictly by the treating specialist.

It is possible to carry out intravenous drip administration of the drug orally; for this, one ampoule of the drug is taken and dissolved in 200 ml of physical solution. After this, 60 drops per minute are injected into a vein. Another proven method of administering the drug is inkjet. This administration is carried out intravenously through the use of a syringe. The solution is not diluted; the speed at which the ampoule is administered is 7 minutes.

Instructions for use of Mexidol

The dosage and release form of the pharmacological product are selected taking into account the pathology, general condition the patient, the ultimate goals pursued by the attending physician. The table shows the main options for influencing the patient using the drug Mexidol.

Pathological condition	The form of the drug used	Dosage (daily)	Duration of therapeutic effect
TBI, consequences of injuries	Pills	800 mg, divided into three doses throughout the day. This is the maximum permissible dose. If possible, the minimum dosage is selected for the patient.	5 days – 2 months (it all depends on the severity of the injury and the body’s reaction to the medicinal products received).
Cerebrovascular accident	Injection	For the first 4 days, 300 mg of the drug is administered by IV. For the remaining time, the patient is given an injection three times a day (100 mg at a time).	No more than 14 days.
Withdrawal syndrome	Pills	Two tablets twice a day. In especially severe cases, it is permissible to take 3 tablets per day for a short time.	5 – 7 days.
Atherosclerosis	Injection	Over the course of a day, the patient is administered a total of 300 mg of the drug (maximum dosage) by intramuscular injection.	The maximum allowable period of admission is 6 weeks.
Encephalopathy (dyscirculatory)	Injection	250 mg is administered intramuscularly twice a day. The maximum daily dose is 500 mg.	2 weeks.
Intoxication with neuroleptics and other drugs of this kind	Injection	The maximum dose is 500 mg. As a rule, it is divided into two steps.	1-2 weeks.
Necrotizing pancreatitis	Injection	The maximum permissible dose is 800 mg. Administered in 2-3 doses.	Until there is a visible improvement in well-being. The dose is reduced gradually.

For the dropper, injection water is used, in which Mexidol is diluted. The approximate rate of drip administration of the drug is 60 drops/min.

Pharmacological effect

Mexidol is used in medical practice to activate blood supply and normalize the metabolic process in the brain. The medication is characterized by the presence of the following pharmacological properties:

• antioxidant;
• membrane-protective;
• anticonvulsant;
• hypolipidemic;
• antihypoxic;
• nootropic;
• anxiolytic.

After a course of treatment with Mexidol (intravenously, intramuscularly or orally):

• the content of dopamine in the brain increases;
• the course of metabolic processes in the brain is normalized;
• cerebral blood supply is normalized;
• blood microcirculation improves;
• blood rheological parameters improve;
• platelet aggregation decreases;
• energy synthesis by cellular mitochondria is activated;
• cell membranes are stabilized;
• the course of metabolic processes in the areas of the myocardium affected by ischemia is normalized;
• the area of ​​the necrosis zone decreases;
• blood flow increases in areas of the myocardium affected by ischemia;
• membranes of postcellular blood structures (erythrocytes and platelets) are stabilized during hemolysis;
• total cholesterol levels decrease;
• LDL levels decrease;
• the severity of symptoms of pancreatogenic toxemia (general blood poisoning) decreases;
• the severity of the syndrome of endogenous intoxication caused by acute pancreatitis decreases;
• the compensatory activity of aerobic glycolysis increases;
• under conditions of oxygen starvation, the degree of inhibition of oxidative processes in the tricarboxylic acid cycle (Krebs cycle) decreases;
• the content of adenosine triphosphate (ATP) and creatine phosphoric acid (creatine phosphate) increases;
• the severity of the consequences of reperfusion syndrome caused by acute coronary insufficiency decreases;
• the electrical activity of the heart and its contractility are restored and improved (in patients with reversible cardiac dysfunction).

Treatment with Mexidol IV or IM allows preserving ganglion cells, as well as nerve fibers of sensitive cells of the retina of the eye in patients with progressive forms of neuropathy caused by ischemic disease and hypoxia.

At the same time, patients experience a significant increase in the functional activity of the retina and optic nerve, and visual acuity increases.

The anti-stress effect of treatment with Mexidol tablets is expressed as:

• restoration (partial or complete) of impaired learning abilities;
• memory restoration;
• reducing the severity of dystrophic and morphological changes in various parts of the brain;
• normalization of behavior after suffering stress;
• disappearance of symptoms of somatovegetative disorders;
• normalization of sleep and wake cycles.

Mexidol is also a remedy that effectively eliminates the symptoms that occur during withdrawal states.

Mexidol injections instructions for use

The second form of release of this medicine is a solution for injection. If regular Mexidol is prescribed in this form, ampoules (injections) are also available without a prescription.

The release version is more effective, since the component - methylhydroxypyridine - immediately enters the systemic bloodstream, has a therapeutic effect, and gives a stable and long-lasting therapeutic effect. The medicine has antioxidant, nootropic, antihypoxic and anxiolytic properties. What does Mexidol help with? Indications for use are:

• Impaired cognitive function;
• Disturbed systemic circulation of the cerebral cortex and not only;
• Nervous disorders with panic attacks, anxiety;
• Open angle glaucoma;
• Insufficient nutrition of brain tissue.

The medication Mexidol injections according to the instructions is injected into the patient’s body into the muscle or intravenously

It is important to discuss single doses and course duration with your doctor in advance.

A similar summary of Mexidol instructions for use states that a single dose of medication depends on the nature of the pathological process, the degree of neglect of the diagnosed disease. These may be the following standards:

1. Traumatic brain injuries – 500 mg / 14 days;
2. Circulatory insufficiency in the cerebral cortex – 100-250 ml / 10 days;
3. Impaired cerebral circulation - 200-500 mg of medication / 14 days.
4. In the presence of mild cognitive impairment, older people inject about 300 mg/day into the muscle for up to thirty days;
5. Acute diseases of a purulent-inflammatory nature - from the first days of treatment and after the end of the operation. The required dosage is calculated by a specialist; the duration of use of the drug will depend on the form and severity of the disease. Features and characteristic features its currents. Mexidol is discontinued gradually, as soon as a stable clinical effect is achieved and blood counts stabilize;
6. For mild necrotizing pancreatitis - up to 200 mg three times a day. Choose one of the administration methods or use a combination of them;
7. For necrotizing pancreatitis, if it is severe, 800 mg is prescribed on the first day in a pulse dosage. For the following days, 200 to 500 mg is prescribed twice a day;
8. Encephalopathy (injections can only be done during the decompensation phase) - 200-400 mg of Mexidol intravenously twice a day for fourteen days. Over the next two weeks, about 200 mg are administered. 1 per day. Preventive measure occurs by administering a solution intramuscularly at 250 mg. twice a day for two weeks;
9. In case of acute poisoning with neuroleptics, 300-500 mg/day is prescribed for a week;
10. For acute pancreatitis, accompanied by swelling, up to 500 mg of the drug Mexidol is prescribed 3 times a day by drip or injection into the muscle;
11. For alcohol withdrawal, 250 mg/daily is prescribed intravenously by drip or three injections into the muscle for one week.

The exact dosage of Mexidol should be selected by a doctor. Mexidol can be administered intravenously by drip. Another method of administration is jet. It is administered directly into a vein using a syringe.

There is no need to dilute this solution. The rate of administration of the ampoule is no more than seven minutes. If Mexidol is injected into a muscle, then it must be given in the center of the upper quadrant of the buttock.

Mexidol injections

Mexidol is administered intramuscularly or intravenously (stream or drip). To prepare a solution for infusion, the drug should be diluted in 0.9% sodium chloride solution.

Mexidol is administered in a stream slowly over 5-7 minutes, drip-wise at a rate of 40-60 drops/min. The maximum daily dose should not exceed 1200 mg.

1. For traumatic brain injury and consequences of traumatic brain injury used for 10-15 days intravenously, 200-500 mg 2-4 times a day.
2. For acute cerebrovascular accidents used in the first 10-14 days intravenously at a dose of 200-500 mg 2-4 times a day, then - intramuscularly at a dose of 200-250 mg 2-3 times a day for 2 weeks.
3. For course prophylaxis dyscirculatory encephalopathy administered intramuscularly at a dose of 200-250 mg 2 times a day for 10-14 days.
4. For dyscirculatory encephalopathy in the decompensation phase used intravenously in a stream or drip at a dose of 200-500 mg 1-2 times/day for 14 days, then intramuscularly at 100-250 mg/day for the next 2 weeks.
5. For mild cognitive impairment in elderly patients and anxiety disorders administered intramuscularly at a dose of 100-300 mg/day for 14-30 days.
6. For open-angle glaucoma of various stages as part of complex therapy, 100-300 mg/day is administered intramuscularly 1-3 times/day for 14 days.
7. With withdrawal symptoms alcohol syndrome administered in a dose of 200-500 mg intravenously or intramuscularly 2-3 times a day for 5-7 days.
8. In case of acute intoxication with antipsychotic drugs administered intravenously at a dose of 200-500 mg/day for 7-14 days.
9. For necrotizing pancreatitis of mild severity Prescribe 100-200 mg 3 times/day intravenously (in isotonic sodium chloride solution) and intramuscularly.
10. For acute edematous (interstitial) pancreatitis Prescribe 200-500 mg 3 times/day intravenously (in isotonic sodium chloride solution) and intramuscularly.
11. For necrotizing pancreatitis of moderate severity– 200 mg 3 times/day intravenously (in isotonic sodium chloride solution).
12. For severe necrotizing pancreatitis- in a pulse dosage of 800 mg on the first day, with a double dose regimen, then - 200-500 mg 2 times a day with a gradual decrease in the daily dose.
13. In acute purulent-inflammatory processes of the abdominal cavity(acute necrotizing pancreatitis, peritonitis) Mexidol is prescribed on the first day both in the preoperative and postoperative periods. The administered doses depend on the form and severity of the disease, the prevalence of the process, and variants of the clinical course. Discontinuation of the drug should be done gradually, only after a stable positive clinical and laboratory effect.
14. In extremely severe forms of necrotizing pancreatitis initial dose of 800 mg/day until persistent relief of the manifestations of pancreatogenic shock, upon stabilization of the condition - 300-500 mg 2 times/day intravenously (in 0.9% sodium chloride solution) with a gradual reduction in the daily dosage.
15. At acute heart attack myocardium as part of complex therapy, Mexidol is administered intravenously or intramuscularly for 14 days, against the background traditional therapy myocardial infarction, including nitrates, beta-blockers, ACE inhibitors, thrombolytics, anticoagulant and antiplatelet agents, as well as symptomatic remedies according to indications. In the first 5 days, to achieve maximum effect, it is advisable to administer the drug intravenously; in the next 9 days, Mexidol can be administered intramuscularly. IV administration of the drug is carried out by drip infusion, slowly (to avoid side effects) in a 0.9% sodium chloride solution or 5% dextrose (glucose) solution in a volume of 100-150 ml for 30-90 minutes. If necessary, a slow jet injection of the drug lasting at least 5 minutes is possible. The drug is administered (IV or IM) 3 times a day every 8 hours. The daily therapeutic dose is 6-9 mg/kg body weight/day, a single dose is 2-3 mg/kg body weight. The maximum daily dose should not exceed 800 mg, a single dose - 250 mg.

Dosage and methods of application. Instructions for use

Mexidol injections are intended for jet or drip injection of a solution into a vein or using intramuscular injections

It is important to know how to properly inject Mexidol intravenously. Typically, an ampoule of the drug must be diluted in a special sodium chloride solution

Why do you need to dilute Mexidol with the solution? The answer is simple: to avoid side effects. How long the process of infusion of the drug takes depends on the method of injection. The procedure takes on average about 5 minutes. If droppers are used, the injection rate is 60 drops per minute. The maximum dose allowed for use during the day is 1.2 grams.

This method of injecting the drug "Mexidol" intramuscular injections is recommended only after careful study of the instructions for use, since the dosage is selected on a strictly individual basis for each specific case, depending on the stage of the disease.

"Mexidol" in the form of a solution - what does it help with and how to use it? Instructions

• in case of severe disturbances in the circulatory processes of the brain: 200 – 500 milligrams, first with the help of droppers, for a course of 10 days to 2 weeks, 4 times a day. Then the drug is administered intramuscularly in a course of 2 weeks, 1 - 2 times a day at a dosage of 200 - 250 milligrams. This comprehensive technique is most effective for achieving positive results throughout the entire treatment process;
• when eliminating the consequences of traumatic brain injuries: a course of 10 to 15 days at a dosage of 200 - 500 milligrams with the amount of administration from 2 to 4;
• in case of insufficient blood supply to the brain of a slowly progressive nature, the drug is injected into a vein for up to 2 weeks, 1 to 2 times a day. In this case, the dosage for each individual patient is individual - 200 - 250 milligrams. Further administration of the solution is supposed to be done by intramuscular injection in a course of up to 2 weeks, 100 - 250 milligrams per day;
• for disorders associated with the cognitive functions of the body, the drug is administered into the muscle for up to 1 month at a dosage of 100 – 300 milligrams per day;
• in case of myocardial infarction, a long complex course of treatment is provided, which involves administering the drug intravenously during the first five days, and then switching to injecting the drug into the muscle in a course of also 5 days. The dosage in both cases is 3 times a day with a time interval of 8 hours. The maximum dose allowed for use is limited to 9 milligrams per day per 1 kilogram of total body weight;
• for open-angle glaucoma, the intramuscular route of drug administration involves a course of up to 14 days at a dosage of 100–300 milligrams with a number of injections from 1 to 3;
• In case of alcohol poisoning, both injection options are possible. The course of therapeutic nature is 5 - 7 days at a dosage of 200 - 500 ml with a frequency of administration 2 - 3 times a day;
• for inflammation with discharge of pus: given acute condition involves surgical intervention. Therefore, injections of Mexidol (Mexiprim) injections are prescribed both one day before the operation and after it in a dosage of 300 - 800 ml per day. Such a large interval in acceptable doses is explained by the severity of the condition in a particular admitted patient.

When prescribing a course of Mexidol injections, discontinuation of the drug is impossible. Treatment should be discontinued gradually by reducing the initial dosage.

Notes Product price category and customer reviews

The cost of the drug "Mexidol" varies between 450 - 2000 rubles, depending on the form of packaging.

After completing a therapeutic course of treatment with the drug, many patients report completely positive results: a general surge of strength, improved vision, cessation of headaches and severe dizziness, reduction of fatigue. There is also a lack of addiction effect. But whether Mexidol injections are painful or not depends on each patient’s individual reaction to both the drug and the pain from the procedure. Most of them note that the procedure is painless.

Read also:

“What does Mexidol help with?

Instructions for use of the drug "Mexidol" »

Mexidol analogues

If these injections give an allergic reaction, adjustment of the treatment regimen is necessary. Drugs similar in composition to Mexidol also act productively, the main thing is to choose the safest one for a particular clinical picture medicine. According to doctors' recommendations, Cerecard, Mexiprim, Mexidant, Neurox, Mexicor have proven themselves well.

Actovegin and Mexidol: The drugs have similar uses and are often prescribed together. Actovegin is produced on the basis of an extract from calf blood, so allergic reactions are more likely to develop to it. Improves nutrition and tissue regeneration. Unlike Mexidol, Actovegin is used for disorders in peripheral vessels, and to treat the consequences of such disorders - trophic ulcers and angiopathy.

What's better than Mexidol? Since the drug has recently appeared on the market, its research is ongoing. In the case of a particular patient, those remedies that give maximum effect. If there is no improvement within two to three days of using Mexidol, it is better to replace it with other drugs. There is no clear answer to the question of which drugs are better. The selection of a treatment regimen is individual and depends on the level of qualifications of the attending physician.

Mexidol or Mexiprim? Mexiprim is a German drug, similar in its properties to the domestic Mexidol. Produced by the Stada Arzneimittel concern. It differs only in the excipients included in the shell and core of the tablets.

Mexidol or Cavinton? The active ingredient of Cavinton is a semi-synthetic derivative of vincamine (devincan) contained in periwinkle - vinpocetine. It is a vasodilator used to improve blood circulation in the brain. Slightly reduces blood pressure, improves the supply of glucose and oxygen to the brain.

It is also used in ophthalmology and the treatment of age-related diseases of the ENT organs. Both drugs complement each other and are often used together in the treatment of cerebrovascular problems. It is not advisable to mix these drugs in one dropper; it is better to administer them separately.

Mexidol or Mildronate? Mildronate (trimethylhydrazinium propionate) is a vasodilator, improves oxygen supply to tissues, increases humoral and tissue immunity, lowers blood pressure, and is used in the treatment of coronary artery disease. It can be prescribed together with Mexidol for withdrawal symptoms and disorders of the blood supply to the brain, since the drugs complement each other.

Mexidol or Neurox? These two drugs are identical and contain the same active ingredient.

Mexidol or Cortexin? Cortexin contains an extract from bovine brain polypeptides. The choice of drug depends on the individual reaction of the patient’s body to it. Together, both drugs are used in the treatment of acute brain hypoxia in newborns. Prescribed only by the attending physician.

Mexidol or Nootropil? The active ingredient of Nootropil is piracetam. The drugs are often prescribed together to treat memory impairment, the consequences of ischemic stroke, alcoholism, and improving learning ability in children.

Pharmacological action and pharmacokinetics

The active substance of the drug is a membrane protector that protects the body's cells from the negative effects of all kinds of toxic substances, especially free radicals, which cause intoxication.

Thanks to this characteristic, the drug is a powerful antioxidant that provides reliable protection from oxidative processes in tissues that cause oxygen starvation and disorders of the central nervous system.

"Mexidol" is capable of:

• inhibit hypoxia processes;
• improve the functioning of cell membranes;
• increase dopamine levels in the brain;
• normalize cerebral circulation;
• stabilize cholesterol levels;
• reduce symptoms of intoxication;
• improve energy balance in cells;
• eliminate cramps;
• restore the electrical activity of the heart;
• protect against emotional swings, reduce susceptibility to stress;
• overcome attacks of panic and anxiety;
• improve attention and memory.

The speed of the therapeutic effect depends on the method of administration of the drug. Intravenous infusions or injections are effective within 2 hours. Oral or intramuscular use provides maximum concentration of the substance for 4 hours.

Metabolism of the drug occurs in the liver with the help of glucoronic acid. Within 12 hours, metabolites and the substance are excreted unchanged in the urine.

Contraindications, side effects and overdose

To obtain maximum benefit from taking the drug, you must carefully read the list of contraindications. He is not big.

There is a categorical ban on the use of Mexidol:

• children under 12 years of age;
• patients with exacerbation of chronic renal failure;
• pregnant women;
• nursing mothers;
• people with lactose intolerance (they can take tablets or injections).

Hyper- and hypotensive patients, drivers and people operating complex equipment should take the drug with caution. The last two contraindications are related to the peculiarity of the drug’s effect on the body.

It reduces concentration and causes drowsiness.

Other side effects rarely develop, because the drug is characterized by low toxicity.

This:

• dry mouth;
• symptoms of dyspepsia - constipation, diarrhea, flatulence, nausea, vomiting, epigastric pain;
• changes in blood pressure;
• sleep problems;
• allergic skin rashes, swelling.

At correct dosage Undesirable symptoms are rare. If you exceed the recommended dose or increase the course of treatment without permission, symptoms such as nausea, heartburn and vomiting are possible. You should immediately stop taking the drug and seek medical help.

Analogs

Among the complete analogues of Mexidol presented in the pharmacy chain, one can name products with the same active ingredient.

Namely:

• "Mexico";
• "Neurox";
• "Mexidant";
• "Cerekard";
• "Mexifil";
• "Mexipridol";
• "Mexibel".

Medicines are presented in tablet form or in the form of injection solutions. Indications for the use of synonymous drugs are almost identical.

Your doctor may also prescribe other medications that are similar in their effects to the medication in question.

The most common analogues in tablets:

• "Glycine";
• "Polyneurin";
• "Cerebronorm";
• "Cytoflavin";
• "Venokor";
• "Actovegin";
• "Elfunat";
• "Armadin";
• "Dinar";
• "Zameksen."

Medicines in the form of a solution for injections:

• "Riluzole";
• "Vitagamma";
• "Combilipen";
• "Emoxibel";
• "Compligam B";
• "Trigamma";
• "Hypoxen";
• "Cytoflavin".

The choice of analogue depends on the characteristics of the treatment, because each of them differs in its effect on the body. The medicine is prescribed only by a doctor, based on the clinical picture of the disease.

Proper use of the drug will effectively eliminate the symptoms of diseases of the central nervous system and improve overall well-being.

Composition, release form and packaging

Mexidol is produced both in tablets and in the form of a solution for injections. The latter looks like a clear liquid, sealed in 2 or 5 ml ampoules. The package usually contains five containers.

Each milliliter of medicine contains:

• ethylmethylhydroxypyridine succinate (medicinal component) – 50 mg;
• sodium metabisulfite;
• water for injections.

This is a very popular drug. Especially for those who had to struggle with abnormalities in the functioning of the brain, including stroke survivors. However, the medicine has proven itself not only in neurology, but also in other areas of medicine, from psychiatry to surgery.

Mexidol toothpaste

The anti-inflammatory and antioxidant effect of Mexidol has found its application in dentistry. Mexidol Dent toothpaste– a wonderful remedy for periodontitis, bleeding and sensitivity of the gums. The paste kills pathogenic bacteria, heals purulent wounds and improves the immunity of the oral mucosa. Dentists recommend brushing your teeth 2-3 times a day. This medicinal paste has the following varieties: MEXIDOL dent Professional White – for teeth whitening; MEXIDOL dent Fito – against bleeding gums; MEXIDOL dent Sensitive reduces tooth sensitivity due to caries, exposure of the neck of teeth and demineralization; MEXIDOL dent Complex – against caries; MEXIDOL dent Aktiv – for the treatment of gum inflammation. All of these toothpastes are effective in the treatment of stomatitis, gingivitis, caries and periodontitis.

In tablets

This is the most accessible form release for a sick person: it is possible to buy tablets without a prescription at any pharmacy. The use of Mexidol should be based on the recommendations of a specialist and study of the instructions. If used correctly medical drug, you can protect the body from intoxication, prevent the appearance of foci of necrosis against the background of spontaneously progressive oxygen starvation. Mexidol (tablets) is prescribed for such conditions of the body as:

• systemic circulatory disorder;
• previous strokes;
• general intoxication of the body;
• encephalopathy;
• long-term stressful conditions;
• extensive nerve damage;
• infectious and inflammatory processes in the body.

Mexidol's instructions tell you how to properly use this medicine in practice. The initial dose of the drug is defined as 1-2 tablets twice a day, but then, on the recommendation of a doctor, it can be increased to 1-2 tablets three times a day. The maximum portion of ethylmethylhydroxypyridine per day is 800 mg, i.e. 6 tablets. Exceeding the daily norms, according to the instructions for use, can lead to an overdose. The duration of therapy varies from 2 to 6 weeks, and must be discussed with the attending physician.

Rules for prescribing the drug

The injectable medicine is administered in two ways: intravenously and intramuscularly. To set up an infusion system, the drug is diluted with 0.9% saline solution. Intravenous injections of Mexidol are given in a stream for 7 minutes. The drip infusion rate is 40-60 drops per minute. The maximum daily dosage is 1200 mg.

Features of therapy for various nosological forms

Instructions for Mexidol injections offer basic treatment regimens for various diseases. For separate disease There is a specific form of administration and duration of treatment. These rules must be followed to avoid complications.

Injections are prescribed according to the following schemes:

Disease	Course, dosage
First 2 weeks	Next 14 days of treatment
Acute hypoxic state of the brain (shock, collapse)	Infusion injections of 200 - 500 mg, 2 - 4 times a day.	According to the instructions, Mexidol injections are given intramuscularly at 200 - 250 mg 2 - 3 times a day.
TBI (including in pediatrics)	For adults, droppers 200 - 500 mg 2 - 4 times a day. Note: the dosage and duration of drug therapy for the child is selected individually.	—
Compensation and prevention of encephalopathies	Intramuscularly 200 - 250 mg twice a day.	—
Decreased cognitive function in patients over 50 years of age suffering from atherosclerosis	The injections are given in gluteal muscle daily dosage of 100 - 300 mg/day. 2-4 weeks.
Ischemic myocardial infarction (MI)	In the first 5 days, infusion or jet; after which injections into the muscle are prescribed for 9 days. Droppers are placed slowly (from ½ hour to 1.5 hours) at 0.9% saline. solution or 5% glucose, 100 - 150 ml. An injection of Mexidol is also prescribed in a stream for 5 minutes (preferably 7). Daily dosage for MI is 6 - 9 mg/kg/day, once 2 - 3 mg/kg body weight. Maximum daily dosage is 800 mg, one-time dosage is 250 mg. Note: The medicine is prescribed in conjunction with standard therapy for myocardial infarction.	If necessary, therapy can be continued (at the discretion of the attending physician).
Glaucoma	Intramuscular administration of the drug 100 - 300 mg/day, 1 - 3 times a day.	—
Poisoning with antipsychotic drugs	Mexidol is administered into a vein at 200 - 500 mg/day.	Treatment can be extended if there is no desired effect.
Purulent-septic diseases (peritonitis, pancreatitis)	The official instructions do not describe the exact timing of treatment. At acute inflammation pancreas Mexidol is used in a dosage of 100-500 mg three times a day, using infusion (with saline solution), as well as injections into the gluteal muscle. The dose is adjusted according to the severity of pancreatitis. The duration and dosage of therapy are determined by the severity of the disease and the effectiveness of treatment measures. Cancellation of Mexidol is carried out gradually with positive dynamics from the use of the drug. Pancreatic shock requires an increase in dose to 800 mg/day.
Alcohol and drug withdrawal syndrome	Intramuscular injections 200 - 500 mg three times a day, 5 - 7 days. It is acceptable to use droppers with the same doses.	—

Mexidol tablets instructions for use

Mexidol tablets instructions for use suggests that these are products that contain 125 mg of the main effect. The drug is quickly absorbed when ingested internal organs and fabrics. TO maximum indicator the concentration of the drug in the body is 3.5 mcg
ml. Excretion is carried out by the kidneys along with urinary fluid, and the unchanged form of the drug is supposed to be administered in small quantities.

Typically, experts prescribe taking the tablet form of the drug 1-2 times a day, one piece, as evidenced by reviews from patients - people taking drug on a regular basis. The initial dosage is 1-2 tablets 2 times a day. If the disease has acute symptoms or is accompanied by complications, dosages may be increased in consultation with a specialist.

The maximum tablets used are 600 mg, taken every 6 weeks. If alcoholism is being treated, therapeutic activities are carried out within a week. The tablets are stopped gradually, regularly reducing the dosage. Use in children controlled by a doctor and prescribed by him. Price tablets is slightly different from the cost of a medicinal injection solution, but this value is small.

What does Mexidol help with?

Mexidol is a drug traditionally used as an antioxidant drug. Having a wide range of indications, it copes with various diseases.

• Neurology: in this area, the drug acts as an antioxidant for cerebrovascular disorders and encephalopathy. The remedy has proven itself well in the treatment of vegetative-vascular dystonia, with cognitive pathological processes due to atherosclerosis associated with impaired speech function, concentration, memory deterioration and intelligence.
• Psychiatry: within this area, the drug is indispensable in alleviating withdrawal symptoms, withdrawal symptoms and poisoning - first indications for use facilities. It is also widely used in cases of intoxication of the body through antipsychotics used to eliminate psychosis and other phenomena. Helps overcome anxiety syndromes associated with neurotic illnesses.
• The surgical industry involves the use of the drug in the event of the formation of purulent and inflammatory processes in the peritoneal space. The drug is widely used in cases of pancreatitis and is part of a wide range of treatment systems for other diseases.

In addition to indications and tasks to be solved, an important role is played by contraindications for application this remedy.

• High sensitivity of individuals to the main substance of action;
• Intolerance to the personal plan of auxiliary components;
• Acute diseases of the liver and kidney type.

The active ingredient of this product is ethylmethylhydroxypyridine succinate. The product is available in several forms with different contents of the active substance - tablets, ampoules, solutions for internal administration. Domestic medicine is relevant to the new generation.

Main contraindications

Before offering Mexidol to the patient, the doctor tells why it is prescribed, in what doses, how long the medicine should be used, and what its main effect on the body is.

The doctor must also take a thorough medical history of his patient, taking into account all possible contraindications:

• acute renal failure;
• acute liver failure;
• increased susceptibility to the main pharmacological substance or auxiliary components;
• childhood;
• pregnancy;
• active lactation period.

The use of the drug for all of the above conditions is inappropriate. In the case of pregnant and lactating patients, the drug product is not prescribed due to the lack of any data on the safety of the pharmacological product.

If the patient cannot tolerate any component of the drug, it makes sense to select a suitable analogue that does not contain a potential allergen.

special instructions

When using Mexidol, a number of recommendations should be followed.

Sometimes, extremely rarely, in the presence of allergic reactions to sulfites, the presence of bronchial asthma, or polyallergies, severe allergic reactions can develop. Such patients, when first prescribed Mexidol, require inpatient monitoring (ideally) or full outpatient monitoring.

There are a number of proven drug interactions between Mexidol and other drugs. You should remember about the possibility of enhancing the effect of antiparkinsonian drugs containing levodopa, anticonvulsants, and benzodiazepine-based anxiolytics. More often it is positive effect, allowing you to reduce the dose, and, consequently, the risk of side effects from the use of these drugs. Mexidol also reduces the toxic effects of ethanol (including reducing intoxication and dizziness from intoxication).

Price

Mexidol injections are available from pharmacies with a doctor's prescription. The price in pharmacies varies due to the markup of suppliers and the own markup of pharmacies, although Mexidol itself is included in the list of Vital and Essential Drugs. Current prices as of October 2017:

• Ampoules 2 ml, No. 10 437-580 rubles.
• Ampoules 2 ml, No. 50 1970-2285 rubles (used more often when purchasing to hospitals and hospitals).
• Ampoules 5 ml, No. 5 415-555 rubles.
• Ampoules 5 ml, No. 20 1640-1810 rubles (used more often for purchases in hospitals).

In comparison with the author’s archive (ampoules 2 ml, No. 10 price 365-527 rubles, ampoules 2 ml, No. 50 2000-2400 rubles, ampoules 5 ml, No. 5 cost 360-495 rubles, ampoules 5 ml, No. 20 1600-1820 rubles), prices increased significantly (up to 20%) for small-sized packages and decreased very slightly for large packages, which generally reflects negative price dynamics for the average person.

You should not self-medicate, it can be dangerous! Before using Mexidol, consult your doctor!

Indications for use of Mexidol

Mexidol is an antioxidant drug necessary to improve blood supply to the brain during purulent processes in the abdominal cavity. It is used for the recovery period during a stroke, as well as for its prevention. Mexidol will be needed to treat stress, in case of poisoning with atarax, aminazine, triftazine. This drug protects cells from destruction when exposed to toxins, helps to survive withdrawal syndrome (in simple words - withdrawal), reduces the effect of drugs and alcohol on human body and very effective for cramps.

Precautionary measures

Strictly follow the instructions for use.

Activities associated with the need for increased concentration and the need for quick psychomotor reactions, including driving, require caution in taking Mexidol.

Patients with a predisposition to bronchial asthma and with high sensitivity to sulfites are at risk of producing negative response reflexes.

Blood pressure indicators should be monitored. If it increases systematically during treatment with Mexidol, you should immediately stop using it.

In the presence of hypertension (any stage, the mildest), the use of the drug requires strict and constant monitoring by a doctor; blood pressure measurements in this case are carried out regularly.

Analogs

We present to your attention a list of common analogues and their average cost:

• Mexidant from 53 rub. for 1 amp;
• Mexiprim from 180 rubles;
• Medomexi from 161 rub. for 1 amp;
• Cerecard from 160 rub. for 5 amp. 5 ml each;
• Neurox from 39 rub. for 1 amp;
• Meksifin from 157 rub. for 1 amp;
• Mexico from 175 rub.

For comparison: 1 ampoule of 50 mg, 2 ml each costs from 52 rubles.

Similar agents that have a different chemical composition but are used in the treatment of the same diseases include:

• Instenon;
• Glycine;
• Cortexin;
• Nootropil;
• Piracetam;
• Armadin;
• Antifront;
• Actovegin;
• Cavinton.

There are schemes when 2 drugs (not structural analogues!) are prescribed at the same time. This is quite justified, since the impact is carried out on different mechanisms of pathogenesis.

Before using analogues, consult your doctor.

Overdose and additional instructions

Nausea, dry mouth, and drowsiness may likely occur. Allergic reactions are possible.

special instructions

In cases of individual hypersensitivity of patients to the components of the drug, allergic reactions are possible

Patients who drive cars need special attention.

Interactions with drugs

There are no peculiarities observed with the parallel use of several drugs.

Mexidol combines quite well with other medications.

Has the ability to reduce the toxic effect of ethyl alcohol.

If necessary, can be taken after drinking alcohol.

Use during pregnancy and lactation

Indications for use

What does it help with? Mexidol is used as an antioxidant agent in neurology, cardiology and psychiatry. Indications for use of the drug are as follows:

1. Panic attacks;
2. Cognitive impairment due to cerebrosclerosis;
3. Psychopathy, withdrawal syndrome;
4. Acute intoxication with psychotropic drugs;
5. Neurasthenic conditions after strong physical exertion;
6. Concussion, consequences of head injuries;
7. Acute and chronic encephalopathies;
8. Autonomic dysfunction;
9. Neurosis-like conditions;
10. Acute coronary circulatory disorders, as an additional therapy;
11. In surgery after surgical interventions, purulent inflammation of the peritoneum and pancreatitis;
12. Residual effects after strokes, as well as during transient cerebral ischemia to prevent exacerbation;
13. For prevention before extreme stress.

Types of medication

For more convenient use, Mexidol is available in ampoules and tablets. Each of these forms has its own characteristics and method of application:

• Ampoules. One package usually contains 5-10 containers of solution. The ampoule can be 2, 5 and 10 ml. Mexidol injections intramuscularly should be done only in mild cases. The attending physician should tell you how much to inject the medicine, based on the patient’s condition. In severe cases, injections are given mainly intravenously. Two types of input are used for this purpose:
  • Dropper. In this option, the speed should be no more than 1 drop per second;
  • Jet method. This type of procedure lasts about 5 minutes depending on the amount of the drug.
• Pills. They are quickly absorbed into the blood through the stomach. The tablets will remain in the body for about 5-6 hours from the moment of administration. The breakdown occurs in the patient’s liver, and the drug is excreted in the form of urine. Mexidol in tablets differs from ampoules in that it can cause additional side effects in the patient’s gastrointestinal tract (constipation, diarrhea, etc.) and enters the blood more slowly.

Before using the drug, you need to find out what it helps with. A neurologist can tell you about this, as well as instructions for use and reviews left by people and doctors about this medication.

Interaction with other drugs

Simultaneous administration (administration) of Mexidol with other medical derivatives:

• Potentiates the effect of: painkillers, anticonvulsants, antiparkinsonian medications, antidepressants, anxiolytics, benzodiazepine derivatives (tranquilizers).
• Significantly reduces the toxic effect of ethyl alcohol.
• Effectively interacts with medications intended for the treatment of somatic diseases, treatment of alcoholic and vascular pathologies.

Attention! There have been no cases of negative reactions from the complex use of Mexidol together with other medicinal products!

Instructions for the use of intramuscular injections

Typically, Mexidol injections are prescribed in cases serious illnesses. The decision to prescribe injections is made only by a doctor; taking this drug on your own is unacceptable and dangerous.

Diseases for which Mexidol injections are prescribed:

Often, after a course of Mexidol injections, the patient is prescribed therapy with this drug in the form of tablets, this allows you to achieve a better and longer-lasting effect from treatment with this drug.

During pregnancy and childhood, Mexidol in the form of injections is not used, since there is no reliable data on its safety in this case. This substance is excreted from the body in the urine, 4-5 hours after entering the blood.

Before injecting Mexidol into a muscle, the contents of the ampoule with the medicine should be dilute isotonic sodium chloride solution. The injection of this drug should be done slowly over several minutes. The maximum dose of Mexidol should not exceed the daily norm, which is 1200 mg per day.

Before injecting this medication, you should carefully study instructions for use, especially if treatment occurs at home.

Side effects

Like any other medicine, Mexidol has its own side effects. It should be noted that this remedy rarely expresses himself negatively, adverse reactions during treatment are observed only in isolated cases, and they do not cause significant harm to health.

Adverse reactions to Mexidol in ampoules:

1. Nausea.
2. Dry mouth.
3. Prostration.
4. Drowsiness.
5. Allergy to the components of the drug.

Adverse reactions to Mexidol tablets:

1. Discomfort and pain in the stomach.
2. Heartburn.
3. Bloating.
4. Diarrhea, constipation.
5. Other intestinal disorders.
6. Weakness and lethargy.
7. Allergy.

In very rare cases, a decrease in blood pressure has been observed under the influence of Mexidol. In addition, there have been cases where patients experienced incoordination, emotional reactivity, and distal hyperhidrosis as a result of taking this drug.

Contraindications

There are very few contraindications that completely exclude the use of Mexidol. Typically, patients are prescribed injections of this drug, without fear serious negative manifestations. However, there are several types of deviations in human health that exclude the possibility of injections or taking pills of this drug.

Deviations:

1. Acute liver failure.
2. Acute renal failure.
3. Hypersensitivity to the drug or its individual components.
4. Pregnancy and lactation period.
5. Childhood.

Doctors of many specializations are actively used Mexidol in the treatment of its patients. This medicine is very popular due to its high efficiency in the treatment of a huge number of ailments.

Mexidol in ampoules

The medication, produced in ampoules, is intended for use by injecting Mexidol solution into a vein or using intramuscular injections. Typically, the capacity of one ampoule is 2 or 5 milliliters. Mexidol in ampoules is a clear liquid.

Characteristics of the pharmacodynamic action of Mexidol injections

“Mexidol” for injection, after administering the solution intramuscularly, begins to actively carry out its chemical and biological processes, penetrating into the blood plasma. The active substance of the drug continues to remain there for another 4 hours. The maximum plasma concentration is achieved within half an hour.

Further, spreading through the bloodstream to all tissues and organs, the active substance ethylmethylhydroxypyridine succinate, ending up in the liver, undergoes a transformation of biological nature. As a result, the product phosphate-3-hydroxypyridine, necessary for metabolic processes, is formed.

The Mexidol solution also has the ability to be rapidly absorbed. Therefore, the active substance does not stay in the body for a long time. Its withdrawal is carried out within a time period of no more than one and a half hours, mainly through urination.

Indications for the use of Mexidol injections

Prescription by a specialist of intravenous or intramuscular injections of Mexidol for a course of injections is indicated in the following cases:

• for acute disorders of circulatory processes;
• for traumatic brain injuries or to eliminate their consequences;
• with insufficient blood supply to the brain of a slowly progressive nature - discioculatory encephalopathy;
• for diseases of the autonomic nervous system - VSD;
• for disorders with anxious neurotic states;
• in the presence of mild forms of cognitive impairment of atherosclerotic properties;
• in case of acute myocardial infarction, in this case, droppers with medicinal solution or intramuscular injections as a set of therapeutic procedures;
• for open-angle glaucoma, Mexidol injections are prescribed intramuscularly at any stage of the disease as part of a complex treatment;
• in case of alcohol poisoning and general drug addiction with subsequent detection VSD violations and manifestations of pseudoneurotic disorders;
• in the presence of pronounced symptoms of intoxication of the body with antipsychotic drugs;
• in the presence of inflammation with the release of pus that forms in the abdomen (abdominal cavity), and possible development, as a consequence of launched acute forms, necrotizing pancreatitis or peritonitis.

Also, indications for prescribing the drug may be somatic diseases that develop as a result of some extreme factor or excessive stress on the body. Mexidol is prescribed as a means of prevention.

General contraindications to the use of the drug "Mexidol". Possible unwanted side effects

There are practically no direct contraindications that would completely exclude the possibility of taking the drug. But there are some factors of human health, the presence of which does not eliminate the manifestation of possible side effects from the use of this drug:

• acute liver and kidney failure;
• in women - during lactation and pregnancy itself;
• increased susceptibility to the component composition of the drug;
• age (not recommended for children).

Possible adverse reactions to Mexidol in ampoules:

• feelings of nausea;
• drying of the throat mucosa;
• fatigue;
• allergic reactions.

Adverse reactions from taking Mexidol tablets:

• pain in the gastrointestinal tract;
• heartburn, colic, bloating in combination with diarrhea or intestinal obstruction;
• lethargic states;
• allergic reactions.

In any case, you should not carry out self-treatment. Taking the drug, and especially Mexidol in ampoules for injection, requires recommendations and qualified assistance from a specialist doctor.

Mexidol's analogs

Ethyl methylhydroxypyridine succinate - in demand in modern pharmacology basis for creating various medications. Mexidol can also be found on the market under other commercial names:

• Mexico;
• Mexibel;
• Mexicofor.

According to the chemical structure, everything listed drugs identical. The release form, dosage and other features of the composition do not differ. However, each drug is selected taking into account a specific pathology, but there are no specific justifications for such a distribution in official medicine.

As for other pharmacological products that are similar in composition and also identical in pharmacological action, the following drugs are considered the most popular:

• Neurox;
• Cerecard;
• Hypoxene;
• Riluzole;
• Vitagamma;
• Emoxybel.

Pharmacological action and pharmacodynamics

Mexidol has phenomenal biological activity.

He:

• activates metabolism;
• improves the functioning of cell membranes;
• normalizes cholesterol levels;
• reduces symptoms of poisoning;
• relieves cramps;
• restores the electrical activity of the heart;
• successfully combats anxiety and panic attacks;
• helps to resist stress;
• improves memory and ability to concentrate;
• normalizes blood supply to the brain;
• stops the processes of negative effects on the body of lack of oxygen.

The medicine quickly penetrates the body at the cellular level, giving the strength to resist situations caused by a lack of oxygen in the blood, including ischemia, hypoxia, and oxygen deficiency in the brain.

In addition, Mexidol is able to remove alcohol toxins and improve the poor health of a person suffering from withdrawal syndrome (the so-called complex of pathologies that arise in a chronic alcoholic due to sharp decline usual dose of alcohol or refusal from it). It also helps during operations for purulent processes in the peritoneum and helps with neurotic and neurotic-like conditions.

The introduction of Mexidol inhibits the formation of free radicals and strengthens the membranes of red blood cells, does not allow platelets to stick together into blood clots, and reduces poisoning caused by acute pancreatitis, when toxins begin to accumulate in the body due to inflammation of the pancreas.

During hypoxia, it reduces the activity of oxidative processes. By increasing coronary blood flow, it improves metabolism in the myocardium suffering from oxygen deficiency, directly in the area of ​​ischemia. It also affects the retina and optic nerve, making vision sharper.

The main active component of the drug increases the content of dopamine (a neurotransmitter that allows you to feel pleasure, not feel pain and is responsible for motor function muscles) in the brain.

Instructions for using Mexidol injections

Appointment decision parenteral route The doctor delivers the medicine. Injections should be performed in a medical facility, subject to antiseptic rules, to prevent infection.

The instructions for using Mexidol injections describe in detail the conditions of use, since the choice of injection dosage and duration of therapy depend on the type of pathology.

Standard packaging contains 5-10 ampoules of 2 ml. Injections are given intramuscularly. Intravenous administration is permissible only in a hospital setting through a dropper. Acceptable jet intravenous introduction, but, again, exclusively under the supervision of a specialist. At home, the best option is to perform intramuscular injections in the buttock.

In each specific situation The dosage, frequency and duration of use is determined by the doctor.

Independent use of Mexidol is permissible for preventive purposes to avoid anxiety disorders and decreased mental abilities. In this situation, the following rules are taken into account:

• Maximum dosage for intramuscular administration is 600 mg per day. It is better to start with 200 mg per day. If there is no result, the dose is increased over time. The ampoules of the drug contain different proportions of the active substance. The most common is Mexidol 5%. But, if you plan to use the maximum dosage, the best solution is to purchase ampoules of Mexidol 10%.
• Daily dosage is divided into 2 administrations: morning and evening. Injections are usually tolerated without complications. The administration of the drug does not cause pain or burning sensation. It is not for nothing that doctors prescribe the drug to children under 12 years of age, and in exceptional situations, to infants.
• Preventive course lasts 10-14 days. It is impossible to give injections for longer without the supervision of a doctor. If you want to enhance the effect, after this period it is better to switch to the tablet form. Again, this is acceptable as long as there are no adverse consequences.

Patients usually treat intramuscular administration of Mexidol with caution, because they think that it is better to administer intravenously. But experts say that there is no particular difference between intramuscular and intravenous administration. Note that the most pronounced result is obtained when performing injections together and taking Mexidol tablets.

Mexidol and alcohol compatibility

Mexidol is a drug that has a nootropic effect, so it is often used to eliminate withdrawal symptoms and symptoms of ethyl alcohol poisoning. Many people believe that if you take a drug simultaneously with alcohol, the effect of the latter can be easily neutralized. But this is just an erroneous assumption.

As the substance penetrates the body, the process of stopping the existing pathology begins, while no protection is provided for the cells. Therefore, to the question of whether can they be used together?, there is only one answer: it is forbidden, since there is no compatibility between substances.

Disobedience in this regard can cause serious negative consequences. consequences in the form of nausea, vomiting, pain and dizziness. However, it is possible to use this drug as a single component in the phased elimination of alcohol dependence. Typically, this technique helps to increase the effectiveness of therapy and instantly eliminate disorders.

Thus, the drug is effective in eliminating numerous ailments and pathological phenomena, and therefore will allow you to recover from any form of many diseases in just a short course. But before using the medicine, it is recommended to consult a specialist.

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