Flemoxin is a generic version of one of the most popular antibiotics in the world - Amoxicillin. The original drug was developed by British pharmacists in the 60s of the last century. On pharmaceutical market Amoxicillin appeared in the early 70s.
Amoxicillin is, without a doubt, one of the safest broad-spectrum antibacterial drugs. According to some reports, this penicillin antibiotic is almost the most prescribed medicine in pediatrics. Almost every reputable pharmaceutical company considers it its duty to release its own Amoxicillin. The Japanese corporation Astellas Pharma also succeeded in this matter by developing Flemoxin.
Flemoxin Solutab stands out from the monotonous background of Amoxicillins due to its release form. After all, the drug is available in the form of dispersible tablets, which have many advantages compared to the pills we are used to.
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In this article we will try to understand how Flemoxin differs from its analogues, and also clarify positive sides drug. And let’s not ignore the negative qualities, which, of course, are also present.
Astellas Pharma: new life for antibiotics
Astellas Pharma is the largest Japanese pharmaceutical concern. It appeared in 2005 thanks to the merger of two well-known Japanese companies: Fujisawa Pharmaceutical Co and Yamanouchi Pharmaceutical Co.
Today Astellas Pharma works in various areas of medicine, creating both original drugs and analogues famous brands. The company also produces several antibiotics, which have become widely known due to their dispersible form.
Each of these drugs has an additional word in the name indicating a special form, - solutab. Dispersible drugs include:
- cephalosporin antibiotic Ceforal solutab;
- Unidox Solutab, widely known in Russia;
- Vilprafen solutab;
- Flemoxin Solutab and Flemoklav Solutab are two related drugs containing Amoxicillin as the active ingredient.
I would like to note that Flemoxin Solutab is registered only in Germany, Iceland, Portugal and the CIS countries.
Flemoxin solutab: composition of the drug
So, Flemoxin contains, as you already understood, the only active component - Amoxicillin - in the form of a stable compound (trihydrate).
Amoxicillin is a semi-synthetic penicillin, which in its chemical structure and spectrum of activity is very similar to Ampicillin.
As additional substances, Flemoxin contains chemical substances, which, in fact, ensure its solubility in a minimum volume of solvent. These include cellulose and MCC - microcrystalline cellulose.
Note that Flemoxin tablets have a pleasant citrus taste due to the addition of tangerine and lemon flavoring.
The color of the tablet can vary from pure white to yellowish or even light yellow. A change in color does not mean that the drug was stored incorrectly. Or, moreover, it is a crude fake. The color variations of Flemoxin are associated with the presence of cellulose compounds in it, in which color changes are allowed.
Forms of release of Flemoxin - for both children and adults
The wide range of Flemoxin includes both children's and adult forms of release, which differ only in dosage.
Unlike conventional oral antibiotics, Flemoxin is not presented in powder form for the preparation of a children's suspension. Therefore, parents of young patients are practically deprived of the opportunity to show their hidden pharmaceutical abilities, calculating the volume of water and diluting the white powder with trembling hands.
So, let’s list the release forms of Flemoxin Solutab.
Children's release forms:
- Flemoxin solutab dosage 125 mg;
- Flemoxin solutab at a dose of 250 mg.
Adult release forms:
- Flemoxin solutab 500 mg;
- Flemoxin solutab at a dose of 1000 mg.
Why can’t you split a Flemoxin tablet?
The oblong tablet of Flemoxin has a cross mark. Most patients believe that the score is needed in order to split the tablet in half. And get a dosage exactly half the original one.
I would like to explain to readers why experts persistently warn patients against such a division.
There may be two reasons why you should not divide the tablet into two parts. Firstly, many tablets are coated with a protective coating that protects them from the destructive properties of hydrochloric acid. However, this does not apply to Flemoxin - it is not coated, so we can go further.
The second and main reason is that when dividing a tablet, it is technically impossible to find out the dosage of the resulting parts. Even if you have a pharmacy scale at hand, and you were able to absolutely accurately divide a 1000 milligram tablet of Flemoxin into two equal parts, the amount of the active substance remains unknown. Why do you think?
Take another look at the drug packaging or instructions for Flemoxin. The composition of any tablet drug (as, by the way, most others) often contains many other substances in addition to the main active component. Using the example of Flemoxin Solutab at a dosage of 125 mg, we see that the content of cellulose, microcellulose (or MCC), as well as flavorings and saccharin is about 17% of the share of Amoxicillin. Wherein active substance is distributed unevenly, and therefore the left half of the tablet may contain N percent more active ingredient than the right half. Or vice versa.
Accordingly, efficiency different parts Flemoxin tablets may be, to put it mildly, different. And side effects too.
Now let’s remember that we are not dealing with ascorbic acid vitamins, but with a drug, the dose of which is carefully selected depending on age and the severity of the infection. And let’s remember the unshakable rule of pharmaceuticals: dividing a tablet in order to reduce the dosage is simply prohibited!
Exceptions may include some cardiac medications. In such cases, the manufacturers themselves take into account all the nuances and technologically achieve uniform distribution of all the components of the tablet.
Dispersible tablet: what is it?
Many patients, when they first encounter the name “dispersible tablet,” have difficulty imagining what it is. Meanwhile, more and more pharmaceutical companies are trying to put older drugs into dispersible form. Dispersible vitamins, antibiotics, and even erectile dysfunction drugs are appearing on the market.
Dispersible tablets were originally created for patients who had difficulty swallowing. This condition, which is medically called dysphagia, occurs in 35% of the general population and in 60% of older people.
The first dispersible tablets dissolved in the mouth to produce gas. Subsequently, new forms were developed, which included cellulose and its compounds. We have already mentioned that Flemoxin solutab is one of these drugs.
Advantages of dispersible form
So, let's figure out how Flemoxin dispersible tablets differ from regular Amoxicillin and what their advantage is.
So, the dispersible form of Flemoxin:
- has high bioavailability.
Flemoxin dispersible tablets are absorbed in the oral cavity directly into the blood, bypassing the gastrointestinal tract. Due to this, the bioavailability of orally soluble tablets is an order of magnitude higher than that of oral tablets;
- quickly reaches peak concentration.
Oral tablets begin to be absorbed into the blood within 15–20 minutes after administration, at best. Dispersible dosage forms (including Flemoxin) are absorbed within 5 minutes after dissolving in the mouth;
- more convenient for pharmaceutical substances that are unstable in water.
An excellent example is children's Flemoxin Solutab 125 mg, which is much more convenient in the form of soluble tablets than Amoxicillin suspension;
- can be used for newborns and infants;
- does not require additional manipulations before use, unlike, for example, a suspension that needs to be prepared;
- may be dissolved in breast milk;
- Requires very little water to dissolve.
Every parent knows how important it is that the medicine is not only effective, but also tasty. A mother who is trying to pour the hated bitter medicine into a sick child while the father is holding the child by the arms and legs is a very sad picture. And not that rare.
Astellas Pharma pharmacists masked the traditionally bitter taste of Amoxicillin with citrus flavors and saccharin. Therefore, Flemoxin Solutab is delicious medicine for children.
Flemoxin pharmacokinetic data provide convincing evidence of its benefits
The pharmacokinetic properties of drugs largely determine their effectiveness. This is an axiom that does not require proof.
For example, one of the most negative aspects of Flemoxin's predecessor, Ampicillin, is low absorption and short half-life. Imagine that two-thirds of the antibiotic is not absorbed at all. That is, you drink one gram of something other than safe drug, and only 300 mg enters the blood. The remaining part is excreted from the body, simultaneously “working” in the intestines on your previously quite viable microflora. Not the most pleasant prospect, is it?
Therefore, one of the main tasks of modern pharmaceuticals is the search for new drugs and forms that have a high level of bioavailability. And Flemoxin Solutab, without any doubt, can be called one of these drugs.
Flemoxin is absorbed into the blood very quickly - within 5-10 minutes - and almost completely. The bioavailability of dispersible Amoxicillin is close to 93%. Note that for oral dosage forms such figures are practically record-breaking. In comparison with oral Amoxicillin, Flemoxin also clearly wins in this indicator. Thus, the bioavailability of conventional tablet forms of Amoxicillin rarely exceeds 75-80%.
Flemoxin packaging: tightness is a condition of preservation
Flemoxin dispersible tablets are extremely sensitive to moisture. To protect the tablet from moisture in the air, it is necessary to ensure that the packaging is completely sealed. Flemoxin is packaged in aluminum blisters, which guarantee protection of the antibiotic from premature decomposition.
If you accidentally squeezed a Flemoxin tablet out of the cell, it is better to either take it immediately or dispose of it, that is, mercilessly throw it in the trash.
It should be remembered that due to the high cellulose content, there is a possibility of gradual dissolution of the tablet in air moisture. And we know that any antibiotic, including Flemoxin, is unstable in a dissolved state.
Therefore, a Flemoxin tablet that was stored in damaged packaging or, even worse, without it, may turn out to be, at best, a harmless dummy.
Flemoxin solutab: spectrum of pharmacological activity
Amoxicillin, the active ingredient in Flemoxin, is active against many gram-positive and gram-negative bacteria. Among them:
- streptococci - Streptococcus pyogenes and Streptococcus pneumonia;
- clostridia;
- gonorrhea pathogens Neisseria gonorrhoeae;
- listeria;
- pathogen peptic ulcer Helicobacter pylori.
Low activity of Flemoxin is recorded against most pathogens of intestinal infections:
- enterococci;
- coli;
- Proteus;
- salmonella;
- Shigella
And finally, Proteus, Enterobacteriaceae, and microorganisms that produce beta-lactamases are absolutely insensitive to the action of Flemoxin.
Beta-lactamases and Flemoxin: a fight for life
In the instructions for Flemoxin and other penicillin, as well as cephalosporin antibiotics, the term “beta-lactamase” is often used. Usually, patients who carefully study the annotations intuitively understand that lactamase is probably something very bad. But it is not always possible to clearly understand what it is and what, exactly, the harm of beta-lacatmaz is.
Let's try to find out who or what this beta-lactamase is. Let's start by remembering when the first penicillins began to be used.
The history of antibiotics goes back more than 70 years. During this period, many microorganisms learned to recognize the destructive antibacterial substance. Modern strains of bacteria already synthesize antidotes for at least two groups of antibiotics - penicillins and cephalosporins. The role of “antidote” is played by special enzymes from the group of beta-lactamases (penicillinases), which destroy the beta-lactam ring of the antibiotic. As a result, the drug is completely inactivated and has no antibacterial effect.
The first bacteria that learned to produce penicillinase were staphylococci. And, if in 1944 only 5% of Staphylococcus aureus strains produced the enzyme, now this figure has increased many times and is almost 90%!
In addition, bacteria that produce beta-lactamase include streptococci, as well as many gram-negative microorganisms, including Klebsiella, Enterobacteriaceae, Pseudomonas and other pathogens.
So, when infected with microorganisms that produce beta-lactamases, neither Flemoxin, nor other analogues of Amoxicillin, nor Ampicillin are absolutely effective.
Therefore, a correct assessment by a doctor when prescribing unprotected penicillins is so important. The specialist’s task is to differentiate the pathogen and “not to miss” in choosing an antibiotic.
Flemoxin or Flemoklav, which is better?
The Astellas Pharma company produces another antibiotic containing Amoxicillin - Flemoclav. Both the name and packaging of the drug are very similar to Flemoxin, however, there is a significant difference between these drugs. Let's figure out how these seemingly similar antibiotics differ.
We have already found out that some strains of microorganisms produce beta-lactamase, which inactivates Flemoxin. Therefore, for many infectious diseases, Amoxicillin, the active ingredient in Flemoxin, is absolutely ineffective.
Researchers British company Beecham, who developed Amoxicillin, managed to find a substance that blocks beta-lactamases. This substance turned out to be clavulanic acid. Scientists have proven that the combination of clavulanic acid and penicillin antibiotics is effective against strains of bacteria that produce beta-lactamase.
This is how a new antibacterial drug with an extended spectrum of action appeared. The original antibiotic was released by Glaxo under the name Augmentin. By the way, thanks to the protective effect of clavulanates, complex antibiotics began to be called protected. After all, clavulanic acid really serves as a real protection for the lactam penicillin ring from destruction!
The Japanese corporation Astellas Pharma has developed a dispersible form of protected Amoxicillin - Flemoklav.
Patients often wonder: which antibiotic is preferable - Flemoxin or Flemoklav? Only a specialist who relies not only on theoretical, but also on practical knowledge can resolve this dilemma.
When deciding on the selection of a particular antibiotic, the doctor evaluates the history of the current disease, as well as experience in treating previous infections. The most important stage selection of antibiotic - differentiation of the pathogen. An error leads to incorrect prescription of the drug, and, therefore, to ineffective treatment.
Making a decision is complicated by the fact that in the vast majority of cases the pathogen is calculated empirically, that is, based on the symptoms of the disease. A qualified doctor will undoubtedly be able to do this. But a medical amateur is definitely not able to do this. Therefore, patients should remember: the decision to prescribe antibiotics and the choice of a specific drug should be entrusted to the doctor or clinical pharmacist. And no one else!
Flemoxin solutab: when to take?
Indications for the use of Flemoxin are primarily related to the spectrum of pharmacological activity of the drug. Note that Amoxicillin is included in the treatment protocols for many infectious diseases.
Modern semi-synthetic penicillin - Flemoxin solutab - is the drug of choice for uncomplicated pathologies of the respiratory tract of bacterial origin. I would like to place special emphasis on the word “uncomplicated”. In case of a moderately severe disease or a severe, complicated course of infection, protected penicillins or antibiotics of other groups are preferred to Flemoxin.
So, let's list the main diseases for which Flemoxin Solutab is indicated:
- spicy otitis media- inflammation of the middle ear.
In the initial treatment of acute otitis media, Flemoxin is the first-line drug, that is, the preferred antibiotic. However, if the disease is aggravated by severe otalgia (ear pain), a temperature above 39 degrees, then the doctor may suspect infection with beta-lactamase producing strains of Haemophilus influenzae and Moraxella catarrhalis. In such cases, the drug of choice is Flemoclav, that is, protected Amoxicillin.
As a rule, these diseases are caused by Streptococcus pyogenes, which are highly sensitive to Amoxicillin. Standard treatment protocols indicate that for bacterial tonsillitis Flemoxin solutab is the drug of choice. However, if the disease is recurrent in nature, that is, it recurs periodically over, for example, one year, then preference is given to a combination with clavulanates, as well as macrolides or cephalosporins.
- lower respiratory tract infections.
The main causative agents of pneumonia and bacterial bronchitis - alpha and beta hemolytic streptococci, Streptococcus pneumoniae, Staphylococcus aureus and Haemophilus influenzae - are sensitive to Flemoxin. Therefore, for uncomplicated bronchitis and pneumonia, Flemoxin Solutab can be used.
- skin infections caused by sensitive streptococci, Staphylococcus aureus and E. coli.
- infections urinary tract.
Flemoxin is effective for inflammatory diseases of the kidneys and bladder if they are caused by sensitive enterococci Enterococcus faecalis, Escherichia coli or Proteus. For the treatment of uncomplicated urinary tract infections caused by enterococcus, Flemoxin is the drug of choice.
However, it is worth considering that some strains of E. coli are resistant, that is, completely insensitive to Amoxicillin. Meanwhile, cystitis - inflammation of the bladder - in most cases is caused by E. coli. Therefore, Flemoxin is prescribed with caution for urological infections.
- typhoid fever and salmonellosis.
Flemoxin is considered an alternative antibiotic for these infections and is used when first-line drugs are contraindicated. Note that the drugs of choice are fluoroquinolone antibiotics and third-generation cephalosporins.
- Lyme disease.
Flemoxin is used in cases of early localized Lyme disease.
Treatment of peptic ulcer with Flemoxin
Long gone are the days when peptic ulcer disease was considered an incurable chronic disease that truly aggravated the patient’s life. Ulcer sufferers no longer need to be teetotalers, drink potato juice on an empty stomach, or poison themselves with vinylin. And especially to lie down on the operating table.
Thanks to the discovery of the role of a banal infection in the formation of ulcers in the wall of the stomach or duodenum, quick and effective therapy for these diseases has become possible. , the causative agent of which is the microorganism Helicobacter pylori, is the cause of peptic ulcer disease in almost 90% of cases. In addition, Helicobacter provokes the development of atrophic gastritis, a dangerous inflammatory disease of the stomach wall, which is a risk factor for ulcers and even stomach cancer.
For a long time, scientists could not even imagine that anything living could survive in a highly hydrochloric acid environment. It turned out that Helicobacter pylori not only survives, but also actively reproduces. The bacterium synthesizes a special enzyme that neutralizes the hydrochloric acid of the stomach - that’s the whole secret of survival.
Meanwhile, Helicobacter responds well to therapy. The complex treatment regimen for infection includes two antibacterial drugs (one of which is Flemoxin), as well as a proton load inhibitor. The last medicine is necessary in order to completely neutralize hydrochloric acid in the stomach. Otherwise, healing of the inflamed area is simply impossible.
So, one of the most effective treatment regimens for peptic ulcer disease includes Amoxicillin (Flemoxin Solutab), Clarithromycin and a proton pump inhibitor (for example, Omeprazole, Lanzaprozole and other drugs). If you are intolerant to Clarithromycin, use a two-component regimen or add Metronidazole as an antimicrobial agent.
STD treatment
The abbreviation STD hides not the most pleasant diseases - diseases that are sexually transmitted.
Flemoxin is used only for two infections, and only in special cases. Let's look at them in more detail:
- gonorrhea.
Amoxicillin was previously widely used to treat uncomplicated cases of gonorrhea. But recently, penicillin-resistant strains of Neisseria gonorrhoeae have emerged, so Flemoxin is often replaced with another antibiotic.
- chlamydia.
Flemoxin is a first-line treatment for uncomplicated urethritis (inflammation of the urethra) and cervicitis (inflammation of the cervical canal) during pregnancy. Note that in most cases of chlamydia in pregnant women, Sumamed is still used instead of Flemoxin or other Amoxicillin, which is considered the drug of choice.
Flemoxin is usually prescribed in case of individual intolerance to macrolides.
Standard dosages of Flemoxin according to the instructions for use
Let us immediately emphasize that any antibacterial drug is dosed individually. And Flemoxin is no exception to the rule. In each specific case, the doctor assesses the severity of the disease, medical history, that is, medical history, as well as concomitant diseases. And based on this information, he selects the correct dosage.
However, there are still standard dosages of Flemoxin - something like the average body temperature in the ward. We emphasize that they are necessary for the doctor, not for the patient. And even more so, you should not rely on this information in order to prescribe the most correct treatment regimen for yourself.
So, according to the instructions for use of Flemoxin, the following dosages are recommended:
- For children from 1 to 3 years old, Flemoxin 250 mg tablets are used twice a day. An alternative prescription may be 125 mg of Flemoxin three times a day at regular intervals;
- The maximum dose of Flemoxin for a child is 60 mg per kilogram of weight per day. This dosage is indicated for severe infectious processes;
- for children from 3 to 10 years old, 375 mg of Flemoxin is prescribed twice or 250 mg three times a day;
- for children over 10 years of age and adults, the average dosage of Flemoxin is 500–750 mg twice or 375–500 mg three times a day.
For severe infections, Flemoxin can be used up to 3 grams per day, certainly divided into three doses.
The duration of treatment, as well as the dosage of Flemoxin, is selected individually. Please note that the minimum course of therapy should not be less than five days. The standard treatment regimen consists of a weekly course of antibiotics. If the infection is caused by the streptococcus Streptococcus pyogenes, Flemoxin is used for at least 10 days.
It is worth emphasizing that antibiotic treatment should not be stopped immediately after the symptoms of the disease disappear. This haste is fraught with the formation of resistant strains from among selected and strong bacteria, on which Flemoxin simply does not have time to act.
In order to avoid complications, it is necessary to continue treatment with Flemoxin for two days after the manifestations of the infection stop. At the same time, we must not forget that the minimum course should not be less than five days.
Chew, swallow, dissolve, or what is the best way to take Flemoxin?
When encountering dispersible tablets for the first time, many patients wonder what is the best way to take Flemoxin. We will try to answer this question and clarify whether there is a difference between the methods of taking this drug.
So, one of the most significant advantages of Flemoxin Solutab is the ability to choose a method of use that is convenient for the patient.
Depending on the individual characteristics and personal preferences of each Flemoxin tablet, you can:
- chew in the mouth;
- suck like a lollipop;
- dissolve in a small amount of cool boiled or simply purified water;
- dissolve in breast milk - for infants;
- dissolve in any juice, compote, tea and other drink. The only condition is that the drink should not be hot.
Let us immediately note that there is no fundamental difference in the methods of application. The rate of absorption, bioavailability and metabolism of Flemoxin do not depend on how long you chewed the tablet or how much juice you diluted in.
In addition, the pharmacokinetic properties of Flemoxin are not affected by food intake. You can take the tablet before meals, during lunch or after dinner, and in all cases the bioavailability of the antibiotic will be the same.
Contraindications to taking Flemoxin
Do not forget that Flemoxin is an antibacterial drug that has both side effects and contraindications. However, in fairness, it is worth noting that Amoxicillin is one of the safest antibiotics.
So, let's list absolute contraindications before taking Flemoxin:
- individual sensitivity to antibiotics penicillin series.
The likelihood of an allergic reaction to Flemoxin is low. However, if you are allergic to medications, and especially antibiotics, do not forget to warn your doctor about this. A specialist will be able to assess the risk and choose the right antibacterial agent.
In addition, do not forget about cross-sensitivity between penicillins and cephalosporins. If you have had an allergic reaction, for example, to ceftriaxone or any other antibiotic from the cephalosporin group, then it is also better to replace Flemoxin.
- Infectious mononucleosis.
Erroneous prescription of Flemoxin and other penicillins for this disease leads to the appearance of an erythematous rash. Note that the symptoms of infectious mononucleosis are similar to those of bacterial pharyngitis and tonsillitis. However, mononucleosis is caused by a virus and does not require antibiotic treatment. Only a doctor can make the correct diagnosis and prescribe the correct medication.
Flemoxin during pregnancy: risks and benefits
Flemoxin is one of the antibiotics conditionally approved for use during pregnancy. The instructions for Flemoxin indicate that the drug can be used in cases where the risk to the child is less than the expected benefit to the mother.
Don't be afraid of this wording. It is caused solely by the fact that clinical trials of Flemoxin on pregnant women have not been carried out, and it is unlikely that they will ever be carried out for obvious reasons.
Nevertheless, Flemoxin is considered one of the safest antibiotics that can be used during pregnancy. And quite a long experience of using it is excellent proof of this. But let us emphasize once again that any antibiotic, including Flemoxin, can only be prescribed by a doctor. Think about your health and the health of your unborn child.
Side effects associated with treatment with Flemoxin
Flemoxin is one of the antibiotics that is well tolerated. However, there is a possibility of adverse events during or after treatment with the drug. Among them:
in 1-10% of cases the following are registered:
- development of vulvovaginal fungal infection (in 2% of patients). In such situations, during treatment with Flemoxin, parallel use of antifungal drugs, for example, Fluconazole, is recommended;
- diarrhea (in 1.7% of patients). As a rule, this symptom does not require discontinuation of Flemoxin and goes away on its own;
- nausea (in 1.3% of patients);
- headache(in 1% of cases).
in less than 1% of cases the following are possible:
- vomiting (0.7% of patients);
- abdominal pain (in 0.3% of patients).
In less than 1% of cases treated with Flemoxin, a rather serious side effect may develop - pseudomembranous colitis. The cause of this condition is a change in the composition of the intestinal flora and the proliferation of opportunistic microorganisms Clostridium difficile. Clinically, pseudomembranous colitis is manifested by severe diarrhea, which is fraught with general dehydration of the body.
When similar symptoms The first thing the patient should do is urgently notify the attending physician. Usually in such cases the only possible solution is to discontinue Flemoxin and prescribe another antibiotic or antimicrobial drug, to which clostridia are sensitive. In addition, recovery plays an important role water-salt balance in organism.
Flemoxin solutab - analogues
The pharmaceutical market is replete with generics of Amoxicillin from a variety of manufacturers. Let's try to list those Flemoxin analogues that have earned positive reviews from doctors:
- Amoxicillin produced by the Serbian company Hemofarm;
- Amoxicillin Sandoz, which is produced by the French corporation Sandoz;
- Hiconcil, a drug from the Slovak company KRKA;
- Ospamox produced by the Austrian pharmaceutical concern Biochemi;
- Amosin, Russian pharmaceutical company Synthesis.
Despite the abundance of analogues of Flemoxin Solutab, very few drugs have the same dispersible form. These include the Austrian Ospamox DT.
And the last thing I would like to note. Despite the wide selection of Flemoxin analogues, one should not forget that the prerogative of both prescribing an antibiotic and selecting a generic belongs exclusively to the doctor.
Unfortunately, sometimes you cannot do without antibiotics, because if left untreated, certain infectious diseases can cause a lot of complications. Certainly, modern market pharmacology offers a huge amount antibacterial drugs. And doctors often prescribe the drug “Flemoxin Solutab 1000 mg” to patients. Instructions, indications, expert reviews, cost and effective analogues - these are the points that are worth considering in more detail.
Information about the release form and composition
In modern medicine, the drug Flemoxin Solutab is often used. Indications, instructions, cost - these are, of course, important issues. However, first you should find out more about the composition of the drug prescribed by your doctor.
The medicine is produced in the form of oval tablets white, often with a yellowish tint. On one side there is a dividing strip, and on the other there is a digital designation of a single dose (1000 mg corresponds to the designation “236”). The tablets are packaged in blisters of 5 or 7 pieces. At the pharmacy you can purchase a package containing 2 or 4 blisters.
Main active component The drug "Flemoxin Solutab 1000 mg", the instructions for which will be discussed below, is amoxicillin in the form of trihydrate. The tablet also contains some excipients, including crospovidone, microcrystalline and dispersible cellulose, saccharin, vanillin, magnesium stearate, and lemon and tangerine flavors.
How does the medicine affect the body? Basic properties
Quite often, doctors recommend taking Flemoxin Solutab 1000 mg tablets for sore throat and other respiratory diseases. Of course, patients are interested in questions about how it affects the body. this medicine. What can Flemoxin Solutab 1000 mg tablets help with?
In order to answer this question, it is worth considering the main pharmacological properties. Amoxicillin is a fairly powerful antibiotic with a wide spectrum of effects. It belongs to the group that has bactericidal properties, is resistant to acids, and therefore remains active after passing through the acidic environment of the stomach.
This substance is active against a variety of gram-positive and gram-negative bacteria, including streptococci and staphylococci, clostridia, bacilli, listeria, and salmonella. But pathogenic microorganisms that produce beta-lactamases are insensitive to this antibiotic.
Pharmacokinetic information
How is the drug “Flemoxin Solutab” (1000 mg) absorbed by the body? The instructions contain information that the main active substance is quickly absorbed by the walls digestive tract. Amoxicillin is resistant to acidic environments. The maximum concentration of this compound in the blood is observed 1-2 hours after administration.
The degree of binding to plasma proteins is 20%. The antibacterial substance quickly penetrates bone tissue, sputum, mucous membranes, intraocular fluid, bile. Amoxicillin is partially metabolized by the liver, and most of the formed substances do not have biological activity.
The active substance of the drug is excreted by the kidneys - the half-life is 1-1.5 hours (if the kidneys are healthy and functioning normally).
In what cases is the drug needed?
When do doctors prescribe the drug Flemoxin Solutab to patients? Indications for use: diseases associated with the activity of pathogenic bacteria.
The medicine is often prescribed for infectious lesions of the gastrointestinal tract and genitourinary system. In addition, the drug is effective against diseases respiratory system— Doctors often prescribe Flemoxin Solutab tablets (1000 mg) for bronchitis, tonsillitis, tonsillitis, and pneumonia. The list of indications also includes ailments of the skin and soft tissues.
Medicine "Flemoxin Solutab" (1000 mg): instructions for use
It is worth understanding that you should not use antibiotics without permission. Only the attending physician, after familiarizing himself with the clinical picture and test results, will be able to draw up a treatment regimen with Flemoxin Solutab (1000 mg). The instructions for use contain only general information.
The medicine is taken regardless of food. The tablet can be swallowed completely with a glass of water, or chewed first. It is possible to grind the tablet into a powder, which can then be dissolved in a small amount of liquid (about 100 mg) - this will result in a suspension with a pleasant citrus taste.
In what quantities should I take the drug “Flemoxin Solutab 1000 mg”? The dosage is determined individually. As a rule, in mild forms bacterial diseases adult patients are recommended to take 500 mg of amoxicillin three times a day (half a tablet). If we are talking about more severe forms infections or recurrent diseases, the dose can be increased to 1 g of antibiotic (one tablet) three times a day. For uncomplicated forms of gonorrhea, patients are prescribed a single dose of 3 g of amoxicillin.
The duration of therapy depends on individual factors. Typically, treatment lasts about 5-7 days. In some cases, the doctor may extend therapy for a few more days.
List of main contraindications
Can all patients take the drug Flemoxin Solutab (1000 mg)? The instructions contain information about the presence of contraindications. You should definitely familiarize yourself with their list before starting therapy.
- The drug is not prescribed to patients with hypersensitivity to amoxicillin, beta-lactam antibiotics, or excipients contained in tablets.
- If you have hypersensitivity to xenobiotics, the medicine can be used, but with caution.
- Relative contraindications include pregnancy. During this period, taking pills is possible only if the benefit to the woman exceeds the level of possible risk to the fetus. Some substances from the drug may partially pass into breast milk, so feeding the newborn should be stopped during therapy.
- Since the antibiotic is excreted by the kidneys, in the presence of diseases excretory system or renal failure, the patient's condition must be constantly monitored.
- When used simultaneously with other penicillin antibiotics, there is a risk of developing superinfection.
- The list of relative contraindications includes the presence of diseases digestive system in the patient's medical history, especially when it comes to colitis.
- If we are talking about the treatment of lymphocytic leukemia or infectious mononucleosis, then taking Flemoxin tablets can lead to the development of non-allergic exanthems.
Are there any possible side effects?
Adverse reactions when taking tablets are rarely recorded. However, this possibility exists, so it is worth familiarizing yourself with the list of complications.
- Digestive disorders are the most frequently reported. Some patients complain of changes in taste, nausea, and diarrhea. It is extremely rare that therapy leads to the development of hemorrhagic and pseudomembranous colitis.
- Occasionally, treatment provokes the development of nephritis, in particular interstitial forms of the disease.
- Disturbances in the functioning of the hematopoietic system are possible. Sometimes during therapy, neutropenia, agranulocytosis, and hemolytic form of anemia are observed.
- It is impossible not to mention allergic reactions. Taking pills sometimes leads to skin rashes, in particular hives. Occasionally, exudative erythema multiforme is recorded. The development of angioedema and shock conditions is possible, but only in the presence of increased sensitivity to antibiotics of this type.
- Disorders from the outside nervous system were not registered.
If during treatment you feel a deterioration, you should immediately report this to your doctor. Sometimes side effects go away after dosage adjustment.
Complications and treatment of overdose
Cases of overdose are rarely recorded, since even large doses of the drug are well tolerated by the human body. However, if you take too many tablets at once, complications may occur. In such cases, patients experience disorders of the digestive system - nausea, severe vomiting, diarrhea. Severe diarrhea can lead to serious violations electrolyte balance and dehydration. That is why the victim must be urgently taken to the hospital.
As a rule, the patient first needs gastric lavage. After this, doctors prescribe sorbents that can bind and remove from the body the remains of the drug that are still in the digestive system. Next, you need to take measures to restore water-electrolyte balance. Serious, irreversible complications in this case are practically not recorded.
The drug "Flemoxin Solutab" (1000 mg): price
Information about the rules of use and possible complications is definitely very important. But for many patients, one of the key questions is how much the drug “Flemoxin Solutab” 1000 mg will cost. The price, of course, will vary depending on the pricing policy of the pharmacy, manufacturing company and other factors. For a package of 20 tablets you will have to pay about 500-600 rubles.
Are there any analogues of the medicine?
This medicine is often used to fight infectious diseases. However, it is not suitable for all patients. What to do in such cases? Is it possible to replace the drug with something?
The modern drug market offers a lot of substitutes. For example, pharmacies sell Amoxicillin with the same active ingredient (the name itself indicates this). This medicine can be purchased in the form of tablets, suspensions, drops and capsules, however, maximum dose- 500 mg of antibiotic. Analogs include the drug “Amoxin”, as well as capsules “Iramox”, “Graximol”, and “Gramox” powder. Of course, choose a safe and effective medicine- This is the task of the attending physician. Using antibiotics without permission is strictly prohibited.
What do doctors and patients say about the drug?
Of course, people who, for one reason or another, have to take the drug are interested in questions about what Flemoxin Solutab tablets (1000 mg) actually are. Reviews about it are mostly positive. The effect of therapy is confirmed by both doctors and their patients. Amoxicillin really copes with infectious diseases of the respiratory tract, skin, and excretory system. Improvement in the patient's condition can be observed within a few days after the start of therapy.
The occurrence of side effects is actually recorded extremely rarely, and the list of contraindications is not that long. An undoubted advantage of the drug is its affordable cost - prices for medications containing the same amoxicillin are often much higher. The drug is really good, which explains the degree to which it is in demand in modern medical practice.
Antibiotics of the penicillin group and, in particular, amoxicillin, are highly effective drugs for the treatment of bacterial infections of the respiratory tract, because extend their activity to a fairly wide range of pathogens. This is, in fact, a well-known fact. The original drug based on amoxicillin, Flemoxin Solutab (hereinafter referred to as Flemoxin) from the Dutch pharmaceutical plant Astellas Europe, is of particular interest: in addition wide range antibacterial action, it has pharmacokinetic and pharmacodynamic characteristics that are very worthy against the general background (bioavailability, absorption, etc.), which, together with a unique dosage form - dispersible (soluble) tablets with apricot flavor - makes it popular among various age groups. Today, flemoxin is a first-line antibiotic in the treatment of acute infectious and inflammatory diseases of the ear/nose/throat and lower respiratory tract.
Flemoxin has a bactericidal effect against such gram-positive and gram-negative bacteria as Streptococcus pneumonia, Streptococcus pyogenes, Clostridium tetani, Neisseria meningitidis, Neisseria gonorrhoeae, Staphylococcus aureus (not producing the enzyme beta-lactamase), Listeria monocytogenes, Bacillus anthracis, Helicobacter pylori. Under certain conditions, the drug can be effective against Escherichia coli, Enterococcus faecalis, Salmonella typhi, Proteus mirabilis, Shigella sonnei, Vibrio cholerae.
Taking flemoxin does not make sense for infections caused by bacteria that produce beta-lactamases, as well as Pseudomonas spp., indole-positive Serratia spp., Proteus spp., Enterobacter spp.
Flemoxin is stable in the acidic environment of the stomach. At orally it is absorbed and distributed in the body very quickly, regardless of food intake. Available only in the form of dispersible tablets, which can be swallowed, divided into pieces or chewed with water. As for the main method of using flemoxin tablets - dissolution, water is used for this in a volume of 20 ml (the final product is syrup) or 100 ml (suspension). According to general recommendations, adults and children over 10 years of age use 500-750 mg of the drug twice or 375-500 mg three times a day. With the peculiarities of using the drug for specific diseases, as well as for young children, can be found in the package insert. The duration of antibiotic therapy for mild and moderate infections is about 5-7 days, and in cases of infections caused by Streptococcus pyogenes - 10 days. Disappearance clinical manifestations disease is by no means a signal to immediately discontinue the drug: it should be taken for another 2 days. If the use of Flemoxin is accompanied by severe diarrhea, then the presence of pseudomembranous colitis can be assumed. In such cases, the drug must be discontinued.
Pharmacology
A bactericidal, acid-resistant, broad-spectrum antibiotic from the group of semisynthetic penicillins. It disrupts the synthesis of peptidoglycan (the supporting polymer of the cell wall) during division and growth, causing lysis of bacteria.
Active against gram-positive and gram-negative microorganisms: Streptococcus pyogenes, Streptococcus pneumoniae, Clostridium tetani, Clostridium welchii, Neisseria gonorrhoeae, Neisseria meningitidis, Staphylococcus aureus (not producing β-lactamases), Bacillus anthracis, Listeria monocytogenes, Helicobacter pylori.
Less active against Enterococcus faecalis, Escherichia coli, Proteus mirabilis, Salmonella typhi, Shigella sonnei, Vibrio cholerae.
Not active against microorganisms producing β-lactamases, Pseudomonas spp., Proteus spp. (indole-positive strains), Serratia spp., Enterobacter spp.
Strains producing penicillinase are resistant to amoxicillin.
Pharmacokinetics
Suction
After oral administration, amoxicillin is absorbed quickly and almost completely (93%) and is not destroyed in the acidic environment of the stomach. Food intake has virtually no effect on the absorption of the drug. After oral administration of 500 mg of amoxicillin, the C max of the active substance, amounting to 5 μg/ml, is observed in the blood plasma after 2 hours. When the dose of the drug is increased or decreased by 2 times, the C max in the blood plasma also changes by 2 times.
Distribution
Plasma protein binding is 17%. Amoxicillin penetrates the mucous membranes, bone tissue, intraocular fluid and sputum in therapeutically effective concentrations. The concentration of amoxicillin in bile exceeds its concentration in blood plasma by 2-4 times. In amniotic fluid and umbilical vessels, the concentration of amoxicillin is 25-30% of its level in the blood plasma of a pregnant woman. Amoxicillin penetrates the BBB poorly; however, with inflammation of the meninges, the concentration is cerebrospinal fluid is about 20% of the concentration in blood plasma.
A small amount is excreted from breast milk.
Metabolism
Amoxicillin is partially metabolized in the liver; most of its metabolites are microbiologically inactive.
Removal
Amoxicillin is excreted 50-70% by the kidneys unchanged (by tubular excretion - 80% and glomerular filtration - 20%), by the liver - 10-20%.
In the absence of renal dysfunction, T1/2 amoxicillin is 1-1.5 hours. In premature infants, newborns and children under 6 months - 3-4 hours.
Pharmacokinetics in special clinical situations
T1/2 of amoxicillin does not change with impaired liver function.
If renal function is impaired (creatinine clearance ≤ 15 ml/min), T1/2 of amoxicillin increases and reaches 8.5 hours in anuria.
Amoxicillin is removed from the body during hemodialysis.
Release form
Dispersible tablets from white to light yellow, oval, with the company logo and digital designation"236" on one side and a score dividing the tablet in half on the other side.
Excipients: dispersible cellulose - 34.8 mg, microcrystalline cellulose - 50.5 mg, crospovidone - 50.4 mg, vanillin - 1 mg, tangerine flavor - 9.1 mg, lemon flavor - 11.1 mg, saccharin - 13.1 mg, magnesium stearate - 6 mg.
5 pieces. - blisters (4) - cardboard packs.
Dosage
The drug is taken orally. The drug is prescribed before, during or after meals. The tablet can be swallowed whole, divided into pieces or chewed with a glass of water, and can also be diluted in water to form a syrup (20 ml) or suspension (100 ml), which has a pleasant fruity taste.
The dosage regimen is set individually, taking into account the severity of the disease, the sensitivity of the pathogen to the drug, and the age of the patient.
In the case of infectious and inflammatory diseases of mild to moderate severity, it is recommended to use the drug according to the following scheme: adults and children over 10 years of age are prescribed 500-750 mg 2 times / day or 375-500 mg 3 times / day; children aged 3 to 10 years are prescribed 375 mg 2 times / day or 250 mg 3 times / day; children aged 1 to 3 years are prescribed 250 mg 2 times a day or 125 mg 3 times a day.
The daily dose of the drug for children (including children under 1 year old) is 30-60 mg/kg/day, divided into 2-3 doses.
When treating severe infections, as well as for hard-to-reach foci of infection (for example, acute otitis media), a three-time dose is recommended.
At chronic diseases, recurrent infections, infections severe course adults are prescribed 0.75-1 g 3 times a day; children - 60 mg/kg/day, divided into 3 doses.
For acute uncomplicated gonorrhea, 3 g of the drug is prescribed in 1 dose in combination with 1 g of probenecid.
In case of mild to moderate infections, the drug is taken for 5-7 days. However, for infections caused by Streptococcus pyogenes, the duration of treatment should be at least 10 days.
The drug must be continued for 48 hours after the symptoms of the disease disappear.
Overdose
Symptoms: gastrointestinal dysfunction - nausea, vomiting, diarrhea; Vomiting and diarrhea may result in water and electrolyte imbalance.
Treatment: gastric lavage, activated charcoal, saline laxatives are prescribed; measures are taken to maintain water and electrolyte balance, hemodialysis.
Interaction
Probenecid, phenylbutazone, oxyphenbutazone, diuretics, allopurinol, NSAIDs, to a lesser extent - acetylsalicylic acid and sulfinpyrazone suppress the tubular secretion of penicillins, which leads to an increase in T1/2 and an increase in the concentration of amoxicillin in the blood plasma.
Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin) exhibit synergism when taken simultaneously.
Antagonism is possible when taken with some bacteriostatic drugs (for example, chloramphenicol, sulfonamides).
Concomitant use of amoxicillin with estrogen-containing oral contraceptives may reduce the effectiveness of the latter and increase the risk of acyclic bleeding.
Antacids, glucosamine, laxatives, aminoglycosides, and food reduce absorption. Ascorbic acid increases absorption.
Increases the effectiveness of indirect anticoagulants (suppressing intestinal microflora, reduces vitamin K synthesis and prothrombin index); enhances the absorption of digoxin.
Concomitant use of amoxicillin with allopurinol increases the risk of developing skin rash.
Side effects
From the digestive system: rarely - changes in taste, nausea, vomiting, diarrhea, dysbacteriosis, stomatitis, glossitis; in some cases - a moderate increase in the activity of liver transaminases, cholestatic jaundice, hepatic cholestasis, acute cytolytic hepatitis, pseudomembranous and hemorrhagic colitis.
From the urinary system: development of interstitial nephritis, crystalluria.
From the hematopoietic system: leukopenia, neutropenia, thrombocytopenic purpura, eosinophilia, thrombocytopenia, agranulocytosis, hemolytic anemia.
From the nervous system: agitation, anxiety, insomnia, ataxia, confusion, behavior changes, depression, peripheral neuropathy, headache, dizziness, epileptic convulsions.
Allergic reactions: skin reactions, mainly in the form of a specific maculopapular rash, urticaria, skin hyperemia, erythematous rashes, rhinitis, conjunctivitis, erythema multiforme exudative (Stevens-Johnson syndrome), fever, arthralgia, eosinophilia, exfoliative dermatitis, reactions similar to serum sickness, toxic epidermal necrolysis, allergic vasculitis, acute generalized exanthematous pustulosis; in some cases - anaphylactic shock, angioedema.
Other: difficulty breathing, vaginal candidomycosis, superinfection (especially in patients with chronic diseases or reduced body resistance).
Indications
Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
- respiratory infections;
- infections of the genitourinary system;
- gastrointestinal infections;
- skin and soft tissue infections.
Contraindications
- hypersensitivity to the components of the drug;
- hypersensitivity to other beta-lactam antibiotics, incl. to other penicillins, cephalosporins, carbapenems.
The drug should be used with caution in cases of polyvalent hypersensitivity to xenobiotics, infectious mononucleosis, lymphocytic leukemia, a history of gastrointestinal diseases (especially with colitis associated with the use of antibiotics), renal failure, during pregnancy and lactation, allergic reactions (including in the anamnesis).
Features of application
Use during pregnancy and breastfeeding
The use of Flemoxin Solutab ® during pregnancy and lactation is possible if the expected benefit of therapy for the mother outweighs the risk of side effects in the fetus and infant.
Amoxicillin is excreted in small quantities into breast milk, which can lead to the development of sensitization phenomena in an infant.
Use for renal impairment
For patients with impaired renal function with CC≤10 ml/min, the dose of the drug is reduced by 15-50%.Use in children
Used in children according to indications according to the dosage regimen.
special instructions
The drug should be prescribed to patients with infectious mononucleosis and lymphocytic leukemia with caution, since there is a high probability of exanthema of non-allergic origin.
A history of erythroderma is not a contraindication for the use of Flemoxin Solutab ® .
Cross-resistance with penicillin drugs and cephalosporins is possible.
The appearance of severe diarrhea, characteristic of pseudomembranous colitis, is an indication for discontinuation of the drug.
During a course of treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.
Superinfection may develop due to the growth of microflora insensitive to the drug, which requires a corresponding change in antibacterial therapy.
At treatment of mild diarrhea in the background course treatment Antidiarrheal drugs that reduce intestinal motility should be avoided; You can use kaolin- or attapulgite-containing antidiarrheal drugs. Treatment must continue for another 48-72 hours after disappearance clinical symptoms diseases.
When using estrogen-containing oral contraceptives and amoxicillin simultaneously, other or additional methods contraception.
Impact on the ability to drive vehicles and operate machinery
There were no reports of adverse effects of the drug on the ability to drive vehicles or operate machines.
The drug Flemoxin Solutab is an antibacterial drug. The composition, if indicated for use, is used in pediatric and therapeutic practice. The antibiotic belongs to the group of semi-synthetic penicillins with a wide spectrum of activity. The medication is a 4-hydroxyl analogue.
Dosage form
The drug is produced in the form of tablets intended for oral administration.
Description and composition
Dispersible tablets are white to light yellow in color. The drug has an oval shape with the company logo and the number 236 on one side and a line dividing the tablet into 3 parts on the reverse. The main active ingredient is 3 1. The list of auxiliary components of the drug can be presented as follows:
- lemon raspberry flavor;
- vanillin flavoring;
- crospovidone;
- magnesium stearate;
- saccharinate;
- microcrystalline cellulose.
Pharmacological group
The antibacterial agent belongs to the group of semisynthetic penicillins with a broad spectrum of activity. The composition is a 4 hydroxyl analogue. The product has a pronounced bactericidal effect. The drug is active against aerobic gram-positive bacteria and gram-negative anaerobic bacteria.
Hepatitis, colitis, allergic reactions, interstitial nephritis are rarely observed. When taken in combination with clavulanic acid, liver disorders may occur.
Interaction with other drugs
Data on drug interactions indicate that it significantly reduces the effectiveness of contraceptives intended for oral administration. Women should find another method to prevent unwanted pregnancy.
When taken simultaneously with bactericidal antibiotics, synergism occurs.
When taken with bacteriostatic and antibiotics, antagonism.
The drug enhances the effect of indirect anticoagulants that suppress intestinal flora.
A decrease in the prothrombin index is possible.
special instructions
Carefully medicine used by persons prone to allergic reactions. During the use of the drug, you should stop using alcoholic drinks. in combination with is not recommended for use in patients under the age of 18 years.
Overdose
When taking the drug in doses significantly higher than those regulated by the instructions adverse reactions– they can manifest themselves with greater intensity. Treatment consists of discontinuing the drug used. If the patient’s well-being sharply deteriorates, it is necessary to contact a qualified medical care.
Storage conditions
Flemoxin Solutab should be stored at a temperature of no more than 25 degrees. Maximum shelf life is 2 years from the date of issue.
The drug is sold to the public through a network of pharmacies for free sale.
Analogues
The drug Flemoxin Solutab has a sufficient number of analogues that can act as its applicant. The list of analogues includes all drugs containing .
It is considered as the most popular analogue, which is a substitute for flemoxin. The composition is designed specifically to eliminate infectious processes and subsequent inflammatory processes in the human body.
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