Atropine is a medication designed to dilate the pupils, available in the form of eye drops. The effect of using the drug lasts for ten days, so the attending physician must take this fact into account in the treatment of a particular patient.
It is worth noting that the drug has many contraindications, so the appropriateness of its use in patient therapy is assessed by the attending physician.
Atropine is prescribed only by an ophthalmologist, who controls the treatment process, so self-administration of these drops is prohibited.
Action
Atropine is a plant component belonging to the group of alkaloids. Its main effect is to dilate the pupils and prevent the outflow of fluid inside the eyes. This effect leads to an increase in intraocular pressure, which may be important in the treatment of certain diseases.
However, taking this drug leads to a certain decrease in visual acuity, so taking eye drops imposes certain restrictions on human activity. During the action of the drug, i.e. approximately in the first ten days after instillation, you need to limit driving a car, as well as operating other units.
The action of Atropine begins half an hour after instillation of the drug into the eye. The effect can last several days, but no more than ten days. After the effect of the drug has ended, the functions of the eye will be completely restored, i.e. it will contract and expand normally. But how glasses with holes are used to restore vision can be seen in this
The therapeutic effect of Atropine is to increase intraocular pressure, so the condition may worsen in patients suffering from glaucoma. In healthy people, such side effects are not observed.
Instructions for use
The decision on the advisability of using Atropine is made by the patient’s attending physician, who draws up a regimen for taking these drops. It may vary depending on the goals of treatment, but the standard use of the drug is as follows. Drops are instilled into the conjunctival sac, 1-2 drops per day. The amount of instillation can be up to three times a day. You also need to maintain a certain time interval between taking the drops, which should be about six hours. But you can see what a conjunctival cyst looks like in a child 
Drops must be instilled in a certain way to reduce the likelihood of developing negative manifestations from using the product. You need to slightly press the lower corner of the eye, and then instill the product, thereby preventing the solution from entering the nasopharynx.
Side effects can be caused not only by the wrong method of instillation, but also if the patient has certain diseases. In particular, the drug is contraindicated for closed-angle and open-angle glaucoma, as well as for synechiae of the iris. Naturally, the drug is also contraindicated if the patient has intolerance to individual components of the drug. It is worthwhile to dwell separately on the issue of studying the issue of
Separately, I would like to mention the most vulnerable categories of patients who should be prescribed this or that drug with extreme caution. We are talking about small children and pregnant women. As for children, the use of Atropine is contraindicated if the child is under 7 years of age.
Interesting on the topic! : indications, contraindications, analogues and correct dosages.
The video shows a description of eye drops:
Regarding the pregnancy period, I would like to say that the appropriateness of using this drug is assessed by the attending physician. There is no direct prohibition, but taking the drops should be done with extreme caution, which involves regularly assessing the mother’s condition.
In addition, there are other factors that need to be considered when prescribing this drug. If they are present in patients, then the drops should be taken with extreme caution:
- Cardiac arrhythmia.
- Arterial hypertension.
- Diseases of the cardiovascular system.
- Intestinal diseases and gastrointestinal problems.
- Increased body temperature.
- Problems with the thyroid gland and urinary system.
All these factors are not direct contraindications, but their presence must be reported to your doctor.
In some cases, patients may experience the following side effects:
If the patient experiences these symptoms, he should immediately stop taking this drug. You also need to consult a doctor so that he can prescribe a medicine similar in its principle of action.
Indications for use
Atropine is used by ophthalmologists to dilate the pupil for diagnostic and therapeutic purposes. In addition, one of the effects of using this remedy is paralysis of eye accommodation, i.e. a condition in which the eyes are unable to change focal length.
All this is necessary solely for diagnostic purposes, which consists of examining the condition of the fundus. In addition, taking these drops allows you to determine the form of myopia, which is very important for further therapy.
In addition, the use of Atropine is advisable in the following cases:
- When you need to provide peace to the eyes, which is required during various diseases and inflammatory processes.
- For injuries to the organs of vision. Here’s how corneal erosion is treated and what the most effective means are:
- If the patient has an increased risk of blood clots.
- To relax the muscles of the visual organs, which speeds up the recovery process.
special instructions
While taking these eye drops, the pupil of the eyes cannot shrink to the optimal size, which is necessary for diagnosing various eye diseases. However, this condition cannot be called normal, so there are certain restrictions associated with driving a car, as well as those devices that require acute vision and good reaction.
While using these drops, you should completely stop wearing contact lenses. If this is not possible, then you can put on lenses, but only one hour after instilling eye drops.
Remember that dilated pupils are the most vulnerable to sunlight, so you need to protect your eyes with sunglasses, which are recommended to be worn throughout the entire treatment period.
Price
The cost of the drug depends on various factors, including the pricing policy of the pharmacy chain. If we consider the average figures for the country, the cost of the drug is about 65-70 rubles per package.
Analogs
The drug Atropine has a certain number of analogues, i.e. medicines with similar principles of action and composition. Let's look at some of them.
Irifrin
The active ingredient of this drug is phenylephrine. Irifrin also promotes vasoconstriction. Thanks to these actions, the drug is used for diagnosis and treatment, as well as as a preparatory measure before surgery.
The product has a dilating effect on the eyes
The use of this drug is contraindicated if the patient's age is less than 12 years. There is also a ban on taking drops by older people who have problems with cerebral vessels, as well as cardiovascular diseases. Pregnancy is not a contraindication, but drops should only be taken after consultation with your doctor.
Midriacil
The active ingredient of the drug is tropicamide. can be used for several purposes - diagnostic, therapeutic, etc. In particular, the drug is used to detect false myopia, diagnose the fundus, and also as a preparatory measure before eye surgery. 
The effect of the drug completely coincides with the effect of taking Atropine. In addition, the contraindications are also quite similar, i.e. Midriacil should not be taken in some forms of glaucoma, as well as in case of intolerance to the components of the drug.
Cyclomed
This drug also has the effect that is required in the diagnosis of certain diseases. In addition, Cyclomed is a must when preparing for laser eye surgery.
The product is necessary for use in the preoperative period
Atropine sulfate
International nonproprietary name
Dosage form
Eye drops 10 mg/ml
Compound
1 ml of solution contains
active substance- atropine sulfate 0.05 g,
Excipients: sodium chloride, sodium metabisulfite, water for injection.
Description
Transparent colorless liquid
Pharmacotherapeutic group
Drugs for the treatment of eye diseases. Mydriatics. Anticholinergics. Atropine.
ATX code S01FA01
Pharmacological properties
Pharmacokinetics
Considering the systemic effect of atropine when swallowing eye drops that enter the nasopharynx through the lacrimal duct, the drug is easily absorbed in the gastrointestinal tract, the bioavailability of the drug is 50%, period
half-life is 13 - 38 hours, atropine is 50% bound to plasma proteins, metabolized in the liver, and excreted by the kidneys 50% unchanged.
Pharmacodynamics
Atropine sulfate reduces the secretion of salivary and other glands, causes tachycardia, improves atrioventricular conduction, reduces the tone of smooth muscle organs, significantly dilates the pupils (with a possible increase in intraocular pressure), and causes paralysis of accommodation.
The mechanism of action is due to the selective blockade of M-cholinergic receptors by atropine (it has a lesser effect on N-cholinergic receptors), as a result of which the latter become insensitive to acetylcholine, which is formed in the area of the endings of postganglionic parasympathetic nerves. Maximum mydriasis occurs after 30 - 40 minutes and persists for 7 - 10 days, paralysis of accommodation occurs after 1 - 3 hours and persists for 8 - 12 days.
The systemic effect of atropine is due to its anticholinergic (cholinolytic) effect and includes inhibition of the secretion of the salivary, gastric, bronchial, sweat glands, pancreas, increased heart rate (the inhibitory effect decreases n.vagus on the heart), decreased tone of smooth muscle organs (bronchial tree, abdominal organs, etc.).
Penetrating the blood-brain barrier, atropine affects the central nervous system. The drug reduces muscle tone and tremor in patients with parkinsonism (central anticholinergic effect); in therapeutic doses, atropine stimulates the respiratory center; large doses of atropine cause motor and mental disorders, convulsions, hallucinatory phenomena, and respiratory paralysis.
Indications for use
Diagnostic dilation of the pupil for fundus examination
To achieve paralysis of accommodation in order to determine the true refraction of the eye
As part of complex therapy for inflammatory diseases, eye injuries, embolism or spasm of the central retinal artery
Directions for use and doses
For therapeutic purposes, adults and children over 7 years of age are prescribed 1-2 drops of atropine 2-3 times a day.
After instilling atropine into the conjunctival cavity, you should immediately press the lacrimal punctum to the nasal septum to prevent the drug from entering the nasal cavity. The duration of the course of treatment is determined by the doctor.
Side effects
Increased intraocular pressure
Hyperemia of the skin of the eyelids, hyperemia and swelling of the conjunctiva (especially with prolonged use)
Photophobia
Tachycardia
Dry mouth, intestinal atony, constipation, dizziness, urinary retention, bladder atony.
Contraindications
glaucoma
urinary dysfunction due to benign prostatic hyperplasia
hypersensitivity to the components of the drug
children up to 7 years old
synechiae of the iris, keratoconus
With caution: ulcerative colitis, paralytic ileus, severe urinary retention due to prostatic hyperplasia, hyperthermia, conditions accompanied by tachycardia (thyrotoxicosis, heart failure, heart surgery), myocardial infarction (risk of increased myocardial ischemia), hypertension, mitral stenosis, arrhythmias , liver and/or kidney failure. The effect of atropine on the esophageal sphincter can lead to increased reflux.
Drug interactions
When using atropine sulfate with monoamine oxidase inhibitors, heart rhythm disturbances occur; with quinine, novocainamide, a summation of the anticholinergic effect is observed.
special instructions
Atropine sulfate should be prescribed with caution, taking into account possible increased individual sensitivity to it. When introducing the drug into the conjunctival sac in the form of drops, it is necessary to compress the area of the lacrimal ducts to prevent the solution from entering the lacrimal canal and being absorbed. In ophthalmological practice, it is advisable to use atropine sulfate primarily for therapeutic purposes, and for diagnostic purposes it is better to use mydriatics of shorter duration. Use with caution in patients with severe damage to the cardiovascular system (arrhythmias, mitral stenosis); with subconjunctival and parabulbar administration, in order to prevent tachycardia, the patient is given a validol tablet under the tongue along with Atropine.
There are no data on the use of contact lenses during the use of atropine sulfate.
Pregnancy and lactation
During pregnancy, the drug is prescribed only if absolutely necessary. When using atropine during lactation, breastfeeding should be stopped, as the drug passes into breast milk and can cause respiratory depression and drowsiness in the child.
Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
During the treatment period, you should refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration, speed of psychomotor reactions and clarity of vision.
Overdose
It is possible that the side effects and systemic effects of atropine may increase: tachycardia, dry mucous membranes, constipation, urinary retention, the occurrence or intensification of symptoms of bronchial obstruction, decreased sweating, the appearance of hyperthermia, especially in children, the development of motor and mental disorders.
Treatment: intravenous administration of physostigmine 0.5-2 mg (no more than 5 mg/day) at a rate of no more than 1 mg per minute or neostigmine methyl sulfate intravenously 0.5-2 mg or intramuscularly 0.5-1 mg every 2-3 hours.
Release form and packaging
5 ml of the drug are placed in glass bottles, hermetically sealed with rubber stoppers, followed by rolling in aluminum caps. A self-adhesive label is placed on the bottles.
The bottle, along with instructions for medical use in the state and Russian languages and a polyethylene dropper cap, is placed in a cardboard pack.
Storage conditions
Rumyantseva Anna Grigorievna
Reading time: 7 minutes
A A
One of the most popular drugs in ophthalmology was Atropine.
Now He is becoming less and less common in ophthalmological practice due to the presence of a lot of side effects.
But in some situations the use of these drops is necessary. The use of this drug should be strictly under the supervision of a physician.
Available as a 1% solution in 5 ml bottles.
pharmachologic effect
Atropine is a plant alkaloid. Contained in various plants of the nightshade family, for example, belladonna, belina.
The main action is to dilate the pupil(mydriasis).
This is associated with a slowdown in the outflow of intraocular fluid and an increase in intraocular pressure.
As a result, paralysis of accommodation develops (the ability of the eye to adapt to changing conditions).
This effect significantly reduces vision, which makes working at close range problematic.
Need to know! The duration of the effect is approximately 4 days, then the work of the eye muscles gradually begins to recover. The maximum duration of action is 10 days.
Penetration of the drug occurs by absorption through the mucous membrane of the eye.
The ciliary muscle that fixes the lens relaxes and moves, which stops the outflow of intraocular fluid. The result is an increase in intraocular pressure.
Instructions for use
They are instilled 1-2 drops of 1% atropine solution in the affected eye(in both eyes in preparation for diagnostic procedures).
According to the instructions for use, use 3 times a day, every 5-6 hours. For children, a solution of lower concentration is used.
Subconjunctival or parabulbar injections can be performed with a 0.1% solution. For subconjunctival injections, the volume of the solution is 0.2-0.5 ml, for parabulbar injections – 0.3-0.5 ml.
Using electrophoresis or eye baths, a 0.5% solution is administered from the anode.
Indications for use
Keep in mind! Drops are used systemically for:
- Gastrointestinal pathologies (spasm, peptic ulcer of the stomach and duodenum, intestinal colic, irritable bowel syndrome and a number of other pathologies);
- Respiratory system disorders (bronchospasm, laryngospasm);
- Premedications for surgical interventions;
- Diseases of the cardiovascular system (AV block, bradycardia).
Locally used in ophthalmology:
Interaction with other medicinal substances
Important! When atropine is used concomitantly with certain groups of drugs, certain effects may occur.
When combined with:
Features of use during pregnancy
Able to penetrate the placenta. When administered intravenously, it can cause a change in the heart rhythm of the fetus (tachycardia).
Remember! Use in pregnant women is indicated only if the therapeutic effect of the drug outweighs the risks to the fetus.
Features of use in children
Used under strict supervision in children with chronic lung diseases– atropine can reduce the secretion of bronchial mucus, which leads to its thickening and clogging of the bronchi.
Side effects
When using this drug the following adverse effects are possible:
Contraindications
- individual intolerance;
- Closed- and open-angle forms of glaucoma;
- Synechia of the iris.
Composition and dispensing from pharmacies
The composition includes a 1% solution of atropine sulfate. Available with prescription doctor
Conditions and shelf life
A drug store out of the reach of children at temperatures up to 25 °C for 5 years.
After the expiration date, the drug should not be used.
Similar medicines
TO similar medicines can be attributed:
Price
average price for Atropine eye drops is about 45 rubles.
Reviews
A month ago I was faced with the fact that to kid at the medical examination discovered poor eyesight. And so, in order to To make a specific diagnosis, the doctor prescribed Atropine drips.
Putting Atropine in a child's eyes is a real punishment. The medicine burns a lot.
However diagnosis we still thanks to this drug they put me in and the drops were stopped.
I consulted an ophthalmologist with complaints of deteriorating vision., after examining me Atropine was prescribed. AND in two hours - again for examination.
There are some inconveniences after using this drug.
For a long time you can’t look at bright light, read, overload your vision, everything around is cloudy and blurry.
But The drug does its job - there is an effect, After the next examination, the doctor prescribed the necessary treatment and told me to take Atropine for another 3 days.
Useful video
This video discusses the drug Atropine and its analogues:
Despite all the side effects atropine doesn't matter takes place in ophthalmology.
The use of this drug must be justified, and its appointment must be carried out by a specialist.
In contact with
APPROVED
By order of the Chairman of the Committee
Pharmaceutical control
Ministry of Health
Republic of Kazakhstan
From "___"___________ 20 ____
№ _______________________
Instructions for medical use
medicine
ATROPINE SULPHATE
Tradename
Atropine sulfate
International nonproprietary name
Atropine sulfate
Dosage form
Eye drops 10mg/ml
Compound
1 ml of solution contains
active substance- atropine sulfate 0.05 g,
Excipients: sodium chloride, sodium metabisulfite, water for injection.
Description
Colorless transparent liquid
Pharmacotherapeutic group
Drugs for the treatment of eye diseases. Mydriatics. Anticholinergics.
Code ATCS01FA01
Pharmacological properties
Pharmacokinetics.
Considering the systemic effect of atropine when swallowing eye drops that enter the nasopharynx through the lacrimal duct, the drug is easily absorbed in the gastrointestinal tract, the bioavailability of the drug is 50%, the half-life is 13 - 38 hours, atropine is 50% bound to blood plasma proteins and is metabolized in the liver, excreted by the kidneys 50% unchanged.
Pharmacodynamics
Atropine sulfate reduces the secretion of salivary and other glands, causes tachycardia, improves atrioventricular conduction, reduces the tone of smooth muscle organs, significantly dilates the pupils (with a possible increase in intraocular pressure), and causes paralysis of accommodation.
The mechanism of action is due to the selective blockade of m-cholinergic receptors by atropine (it has a lesser effect on n-cholinergic receptors), as a result of which the latter become insensitive to acetylcholine, which is formed in the area of the endings of postganglionic parasympathetic nerves. Maximum mydriasis occurs after 30 - 40 minutes and persists for 7 - 10 days, paralysis of accommodation occurs after 1 - 3 hours and persists for 8 - 12 days.
The systemic effect of atropine is due to its anticholinergic (cholinolytic) effect and includes inhibition of the secretion of the salivary, gastric, bronchial, sweat glands, pancreas, increased heart rate (the inhibitory effect of the n.vagus on the heart decreases), decreased tone of smooth muscle organs (bronchial tree, abdominal organs). cavities, etc.).
Penetrating the blood-brain barrier, atropine affects the central nervous system. The drug reduces muscle tone and tremor in patients with parkinsonism (central anticholinergic effect); in therapeutic doses, atropine stimulates the respiratory center; large doses of atropine cause motor and mental disorders, convulsions, hallucinatory phenomena, and respiratory paralysis.
Indications for use
Diagnostic dilation of the pupil for fundus examination
To achieve paralysis of accommodation in order to determine the true refraction of the eye
As part of complex therapy for inflammatory diseases, eye injuries, embolism or spasm of the central retinal artery
Directions for use and doses
For medicinal purposes adults and children over 7 years old Prescribe 1 - 2 drops of atropine 2 - 3 times a day.
Side effects
Increased intraocular pressure
Hyperemia of the skin of the eyelids, hyperemia and swelling of the conjunctiva (especially with prolonged use)
Photophobia
Tachycardia
Dry mouth.
Contraindications
Glaucoma
Difficulty urinating in benign prostatic hyperplasia
Hypersensitivity to the components of the drug
Children's age up to 7 years
Drug interactions
When using atropine sulfate with monoamine oxidase inhibitors, heart rhythm disturbances occur; with quinine, novocainamide, a summation of the anticholinergic effect is observed.
special instructions
Atropine sulfate should be prescribed with caution, taking into account possible increased individual sensitivity to it. When introducing the drug into the conjunctival sac in the form of drops, it is necessary to compress the area of the lacrimal ducts to prevent the solution from entering the lacrimal canal and being absorbed. In ophthalmological practice, it is advisable to use atropine sulfate primarily for therapeutic purposes, and for diagnostic purposes it is better to use mydriatics of shorter duration.
There are no data on the use of contact lenses during the use of atropine sulfate.
Pregnancy and lactation
During pregnancy, the drug is prescribed only if absolutely necessary. When using atropine during lactation, breastfeeding should be stopped, as the drug passes into breast milk and can cause respiratory depression and drowsiness in the child.
Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
Pharmacological.
Atropine sulfate reduces the secretion of the salivary and other glands, causes tachycardia, improves AV conduction, reduces the tone of the smooth muscles of the organs, significantly dilates the pupil (with a possible increase in intraocular pressure), causes paralysis of accommodation.
The mechanism of action is due to the selective blockade by atropine of m cholinergic receptors (it has a lesser effect on n-cholinergic receptors), as a result of which the latter become insensitive to acetylcholine, which is formed in the area of the endings of postganglionic parasympathetic nerves. The ability of atropine to bind to cholinergic receptors is explained by the presence in its molecule of a fragment that gives it an affinity with the molecule of the endogenous ligand - acetylcholine. The pupil is dilated with atropine and does not constrict when instilled with cholinomimetic drugs. Maximum mydriasis occurs after 30-40 minutes and persists for 7-10 days, paralysis of accommodation - respectively, after 1-3 hours and persists for 8-12 days.
The systemic effect of atropine is due to its anticholinergic (cholinolytic) effect, which manifests itself in the inhibition of the secretion of the salivary, gastric, bronchial, sweat glands, pancreas, increased heart rate (the inhibitory effect decreases n.vagus on the heart), decreased tone of smooth muscles of organs (bronchial tree, abdominal organs).
Penetrating the blood-brain barrier, atropine affects the central nervous system. The drug reduces muscle tone and tremor in patients with parkinsonism (central anticholinergic effect); in therapeutic doses, atropine stimulates the respiratory center; large doses of atropine cause motor and mental disorders, convulsions, hallucinatory phenomena, and respiratory paralysis.
Pharmacokinetics.
Considering the systemic effect of atropine when swallowing eye drops that enter the nasopharynx through the lacrimal duct, the drug is easily absorbed in the digestive tract, bioavailability is 50%, half-life is 13-38 hours, atropine is 50% bound to blood plasma proteins, metabolized in the liver, 50% is excreted unchanged by the kidneys.
Indications
Diagnostic dilation of the pupil during examination of the fundus, to achieve paralysis of accommodation in order to determine the true refraction of the eye, in the complex treatment of inflammatory diseases, eye injuries and embolism, spasm of the central retinal artery.
Contraindications
Hypersensitivity to the components of the drug.
Diseases of the cardiovascular system in which an increase in heart rate may be undesirable: atrial fibrillation, tachycardia, chronic heart failure, coronary heart disease, mitral stenosis, severe arterial hypertension. Acute bleeding. Thyrotoxicosis. Hyperthermic syndrome. Diseases of the gastrointestinal tract accompanied by obstruction (achalasia of the esophagus, pyloric stenosis, intestinal atony). Glaucoma. Liver and kidney failure. Myasthenia gravis. Urinary retention or predisposition to it. Brain damage.
Interaction with other drugs and other types of interactions
When atropine sulfate is used together with MAO inhibitors, heart rhythm disturbances occur with quinidine, novocainamide - a potentiation of the anticholinergic effect is observed.
When used with lily of the valley preparations, a physicochemical interaction is observed with tannin, which leads to a mutual weakening of the effects.
Atropine sulfate reduces the duration and depth of action of narcotic drugs, weakens the analgesic effect of opiates.
When used simultaneously with diphenhydramine or diprazine, the effect of atropine increases; with nitrates, haloperidol, corticosteroids for systemic use - the likelihood of increasing intraocular pressure increases; with sertraline - the depressive effect of both drugs increases; with spironolactone, minoxidil - the effect of spironolactone and minoxidil decreases; with penicillins - the effect of both drugs is enhanced, with nizatidine - the effect of nizatidine is enhanced, ketoconazole - the absorption of ketoconazole is reduced, with ascorbic acid and attapulgitis - the effect of atropine is reduced, with pilocarpine - the effect of pilocarpine in the treatment of glaucoma is reduced, with oxprenolone - the antihypertensive effect of the drug is reduced. Under the influence of octadin, it is possible to reduce the hyposecretory effect of atropine, which weakens the effect of M-cholinomimetics and anticholinesterase drugs. When used simultaneously with sulfonamide drugs, the risk of kidney damage increases; with drugs containing potassium, the formation of intestinal ulcers is possible; with nonsteroidal anti-inflammatory drugs, the risk of gastric ulcers and bleeding increases.
The effect of atropine sulfate can be enhanced by the simultaneous use of other drugs with an antimuscarinic effect, M-anticholinergics, antiparkinsonian drugs (amantadine), antispasmodics, some antihistamines, butyrophenone group drugs, phenothiazines, dispyramidives, quinidine and tricyclic antidepressants, non-selective monoamine reuptake inhibitors.
Inhibition of peristalsis under the influence of atropine can lead to changes in the absorption of other drugs.
Features of application
When introducing the drug into the conjunctival sac in the form of drops, it is necessary to compress the area of the lacrimal ducts to prevent the solution from entering the lacrimal canal and being absorbed. In ophthalmological practice, it is advisable to use atropine sulfate primarily for therapeutic purposes, and for diagnostic purposes, it is better to use mydriatics of shorter duration, in particular homatropine (maximum mydriasis - after 40-60 minutes, duration of pupil dilation and paralysis of accommodation - 1-2 days).
For subconjunctival or parabulbar administration, validol should be administered sublingually to reduce tachycardia.
Considering the systemic effect of atropine when swallowing eye drops that enter the nasopharynx through the lacrimal canal, it should be used with caution in patients with prostatic hypertrophy without urinary tract obstruction, with Down's disease, with cerebral palsy, reflux esophagitis, hiatal hernia, combined with reflux esophagitis, ulcerative colitis, megacolon, patients with xerostomia, elderly or debilitated patients, chronic lung diseases with reversible obstruction, chronic lung diseases with low production of thick sputum, which is difficult to separate, especially in young children and weakened patients with autonomic (autonomic) neuropathy.
There are no data on the use of contact lenses when using atropine sulfate.
Use with caution in elderly patients (over 60 years of age).
If it is necessary to use any other eye drops during treatment, the interval between instillations should be at least 15 minutes.
Use during pregnancy or breastfeeding
The drug is contraindicated during pregnancy.
During breastfeeding, with the possible development of systemic effects when using eye drops from the mother, atropine passes into breast milk and can cause respiratory depression and drowsiness in the child. The use of atropine sulfate during breastfeeding is contraindicated due to the risk of developing toxic effects on the child.
The ability to influence the reaction rate when driving vehicles or other mechanisms
During the treatment period, you should refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration, speed of psychomotor reactions and clarity of vision.
Directions for use and doses
For therapeutic purposes, adults and children over 7 years of age are prescribed 1-2 drops 2-6 times a day. Maximum dilation of the pupils with atropine, which promotes relaxation of the eye muscles and accelerates regression of the pathological process, is observed after 30-40 minutes and persists for 7-10 days, paralysis of accommodation - respectively after 1-3 hours and persists for 8-12 days.
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