Antibacterial agent for topical use in ophthalmology, sulfanilamide derivative. Has a wide spectrum of antimicrobial action. Has a bacteriostatic effect. The mechanism of action is associated with competitive antagonism with PABA and competitive inhibition of dihydropteroate synthetase, which leads to disruption of the synthesis of tetrahydrofolic acid, necessary for the synthesis of purines and pyrimidines.
Sulfacetamide is active against gram-positive and gram-negative bacteria (including pathogenic cocci, Escherichia coli), Chlamydia spp., Actinomyces spp.
Pharmacokinetics
When applied topically, it penetrates into the tissues and fluids of the eye. Absorbed into the systemic circulation through the inflamed conjunctiva.
Indications
Purulent corneal ulcers, conjunctivitis, blepharitis, gonorrheal eye diseases in newborns and adults, prevention of blenorrhea in newborns.
Dosage regimen
Apply 2-3 drops into the lower conjunctival sac of each eye 5-6 times/
To prevent blenorrhea in newborns, 2 drops of the solution are instilled into the eyes immediately after birth and 2 drops after 2 hours.
Side effect
Local reactions: itching, redness, swelling.
Contraindications
Hypersensitivity to sulfacetamide and other sulfa drugs.
special instructions
Patients hypersensitive to furosemide, thiazide diuretics, sulfonylureas, or carbonic anhydrase inhibitors may be hypersensitive to sulfacetamide.
Drug interactions
Sulfacetamide, when applied topically, is incompatible with silver salts.
Russian ophthalmic product Sulfacyl sodium is an antibacterial drug used to treat eye diseases.
The uniqueness of the medicine lies in the possibility of treating newborn children with its help.
Despite the minimum of contraindications and adverse reactions, drops should be used with caution and only as prescribed by a doctor.
Compound
- sulfacetamide;
- sodium thiosulfate;
- hydrochloric acid;
- sterile water.
Available in tubes with a convenient dropper dispenser.
Recipe in Latin
Sulfacylum natrium
Active ingredient formula
Indications for use
Prescribed in therapy:
- purulent corneal ulcers;
- gonorrheal eye diseases (both in adults and newborns).
Also, the use of drops is advisable in preventive measures against the development of blenorrhea in infants. The drug is highly effective in treatment.
Contraindications, possible adverse reactions
Among the contraindications, only individual immunity of the body to the components of the composition is noted.
When the drug is used correctly, as prescribed by the doctor, side effects occur extremely rarely. A negative reaction is mainly manifested by itching, swelling and redness of the eyes.
For women during pregnancy and breastfeeding, an ophthalmic agent can be prescribed at the discretion of the doctor. According to clinical data, the components included in the drops do not have a negative effect on either the woman’s health or the baby’s development.
Overdose
Excessively active instillation of the drug into the eyes can lead to an overdose.
Her symptoms:
- burning;
- pain in the eyes;
Also, many patients with an overdose complain of discomfort and a feeling in the eyes.
In case of undesirable reactions, it is necessary to reduce the dosage of drops to a minimum. It is recommended to consult with a specialist about the possibility of further use of the drug.
Instructions for use
Optimal dosage – 2 drops in each eye, the drug is instilled into the conjunctival sac.
Dosage – up to 6 times a day. The break between instillation should be at least 3 hours.
The duration of therapy is determined by the doctor individually, depending on the patient’s age, his diagnosis and response to the drug.
A more detailed description of the treatment regimen depending on the diagnosis is presented in the table:
| Diagnosis | Patient age | Single dosage | Number of daily procedures |
| Ulcerative lesion of the cornea | Adults | 1 to 3 drops | Up to 6 times |
| Ulcerative lesion of the cornea | Children | 1 drop each | No more than 5 times |
| Gonorrheal eye disease | Adults | 2 drops each | Up to 8 times |
| Gonorrheal eye disease | Children | 1 drop each | Up to 6 times |
| Conjunctivitis, blepharitis | Adults | 3 drops each | 4 to 6 times |
For children infancy the use of drops in the prevention of blenorrhea is prescribed 2 drops in each eye, after 2 hours the procedure is repeated.
Please note: after opening the bottle, the drug can be used for no more than 28 days.
Price
The price of the drug Sulfacyl sodium 20% depends on the pharmaceutical company producing it. The approximate cost is presented in the table:
| Company manufacturer | Dosage, ml | Approximate cost, rub |
| Synthesis | 5 | 38 |
| PFC update | 5 | 51 |
| Rewenal | 2 bottles of 2 ml | 76 |
| Grotesque | 5 | 87 |
| Slavic pharmacy | 10 | 31 |
| Diapharm | 10 | 50 |
| MEZ | 2 bottles of 1.5 ml | 60 |
The drug is sold only with a doctor's prescription.
Additional ingredients: sodium thiosulfate, purified water, hydrochloric acid.
Release form
In pharmacies you can find Sulfacyl Sodium eye drops 20%, 30%, as well as powder in packaging.
pharmachologic effect
The medicine has antimicrobial properties.
Pharmacodynamics and pharmacokinetics
Pharmacopoeia indicates that the formula of Sodium Sulfacyl is CsHgSaNaOsS-b^O. INN – Sulfacetamide . The recipe in Latin will contain the name Sulfacylum-natrium.
Eye drops inhibit absorption PABC , and also interfere with the synthesis PABA-containing growth factors microorganisms.
The medicine is characterized antibacterial properties. It acts on streptococci , gonococci , coli , chlamydia , pneumococci , actinomycetes .
An aqueous solution of Sodium Sulfacyl has a slightly alkaline reaction, which allows it to be instilled into conjunctival sac eyes.
Indications for use
Eye drops are used for gonorrheal eye diseases, blenorrhea , purulent corneal ulcers, blepharitis and other eye diseases. The drug can be used by both children and adults, including for the purpose of prevention blennorrhea in infants. In the case of purulent processes, it stops them and accelerates the healing of the cornea.
Prescribed for therapy streptoderma And staphyloderma , infections , provoked coli .
The medicine can be used orally in case of colibacillary infections urinary tract, mastoiditis , puerperal sepsis and others infectious diseases .
Contraindications
This product should not be used if you are hypersensitive to its components.
Side effects
In some cases, when taking the drug, tissue irritation may occur, including redness, eyelids, etc. When using the medicine orally, it is possible dyspeptic disorders .
Instructions for use of Sulfacyl Sodium (Method and dosage)
For those who are indicated for Sulfacyl Sodium eye drops, the instructions for use advise that instillation should be carried out in conjunctival sac . For adult patients, a dosage of 1-2 drops is prescribed. The product is applied 5-6 times a day (every 4-8 hours). In childhood, a solution of 10 percent and 20 percent is indicated. To prevent development blennorrhea Immediately after birth, babies are instilled with 2 drops of the product, and then 2 drops every 2 hours.
The medicine can also be used in vaseline-based ointments 10-30% in case of blepharitis and skin of the eyelids.
Instructions for use of Sulfacyl Sodium indicate that the duration of therapy directly depends on the severity of the disease. It is not recommended to use the medicine for longer without consulting a specialist.
When gonorrheal eye diseases are prescribed combination therapy . Instill a 30% solution or dust the affected area with powder; in addition, take the drug by mouth.
Infected wounds treated using powder.
The maximum single dosage for adults orally is 2 g, the maximum daily dosage is 7 g.
Before using the drops for the first time, the cap is screwed all the way down. A spike on the inside pierces a hole in the membrane. Before use, you need to hold the bottle in your palm for a while to warm the product to body temperature. The cap is unscrewed and after light pressure on the body of the bottle, the solution is dripped into the eyes. Then the bottle should be closed again.
Overdose
In case of overdose, redness, swelling of the eyelids, and itching are possible. Then they continue to use a lower concentration of the drug or completely discontinue the drug.
Interaction
If you need to take other drugs in combination with Sulfacyl Sodium, you should consult your doctor.
Bacteriostatic the effect of the drug is reduced when combined with, and. And its toxicity increases when interacting with, salicylates And para-aminosalicylic acid . If used together with indirect anticoagulants it is possible to increase their specific activity.
Drops should not be used together with salts of some alkaloids, with agents including silver salts, with, as well as with acids and substances that have an acidic reaction.
Terms of sale
The drug is sold without a prescription.
Storage conditions
It is necessary to keep the drug in a dark place. The optimal temperature is 15-25°C.
Best before date
2 years. After the first use, you should keep the product for no longer than 4 weeks.
Analogues
Level 4 ATX code matches:The following analogues of the drug are known: Acetopt , Ophthalemide , Sebizon , Sulfaprocul , Sulfacyl , Sulfacyl soluble , Almocetamide , Octzetan , Prontamid , Sobizon , Sulfacetamide Sodium , Sulfacyl Sodium-DIA .
Albucid and Sulfacyl Sodium
What is more effective Albucid or Sodium Sulfacyl, they often ask on forums. Experts answer that these are actually synonyms. Thus, Albucid – this is Sulfacyl Sodium. This drug is also available in the form of eye drops and is used for diseases caused by streptococci , pneumococci , gonococci . However, relatively recently Albucid and Sulfacyl Sodium began to be used for instillation into the nose.
Sulfacyl Sodium for children
Sulfacyl Sodium for children is used in a dosage of 2-3 drops (20% solution). The child should be in a sitting or lying position. You should carefully open your eyelids and drip the medicine. It is recommended to start from the place where the inflammation is less pronounced.
When acute otitis the drug is instilled into the ears. It can be diluted in boiled water 2-4 times.
Newborns
Medicine for newborns is usually instilled immediately after birth to prevent the development of blennorrhea .
In addition, Sodium Sulfacyl is often used in the nose of infants. The doctor prescribes this remedy for a prolonged runny nose, especially when it comes to bacterial infection . It should be borne in mind that if the drug gets into the nose, it can cause a burning sensation, which is why the child begins to be capricious.
During pregnancy (and lactation)
After consultation with a doctor, the medicine can be used for. It can also be used during. Use the drug when pregnancy And lactation necessary in doses prescribed by a specialist. It is not recommended to increase the dosage on your own.
Reviews of Sulfacyl Sodium
Numerous positive reviews about eye drops indicate their effectiveness. Those who have tried this remedy note its rapid action. After 1-3 days, it helps get rid of irritation and redness of the eyes. Among the negative aspects, reviews of Sulfacyl Sodium only note a slight burning sensation when used.
Price of Sodium Sulfacyl, where to buy
The price of Sulfacyl Sodium eye drops 20% is about 50 rubles. In some pharmacies the cost of this product reaches 85 rubles. The average price of Sulfacyl Sodium in Ukraine is 10 hryvnia.
- Online pharmacies in Russia Russia
- Online pharmacies in Ukraine Ukraine
ZdravCity
Sulfacyl sodium-DIA eye drops 20% vial - cap. 10ml CJSC Diapharm
Sulfacyl sodium eye drops 20% tube-drops. 2ml 2 pcs. PFC UpdateJSC Renewal PFK
Sulfacyl sodium-SOLOpharm eye drops 20% tube dropper 0.5 ml 5 pcs LLC "Grotex"
Sulfacyl sodium-DIA eye drops 20% vial - cap. 5ml CJSC Diapharm
Pharmacy Dialogue
Sulfacyl sodium (vial-drop. 20% 5ml (individual packaging)) Diapharm CJSC
sulfacetamide: Albucid, Sulfacetamide, Sulfacetamide sodium, Sulfacyl, Sulfacyl sodium-DIA, Sulfacyl sodium, Sulfacyl sodium, Sulfacyl ointment.
Sulfacyl sodium - Sulfacetamide
Sulfacyl sodium is an antibacterial drug from the sulfonamide group.
Latin name:
SULFACYLUM-NATRIUM
Active ingredient:
Sulfacetamide
Composition and release form:
Eye drops 20%, 30% 10 ml
10 ml of sterile solution contains 2 or 3 g of sodium sulfacyl.
Pharmacological properties:
Sulfacyl sodium is an antibacterial drug from the sulfonamide group. Its action is associated with a disruption of the synthesis by microorganisms of folic and dihydrofolic acids, which they need for life. Effective against streptococcal, gonococcal, coli-bacillary infections.
Indications:
Sulfacyl sodium eye drops are used for purulent conjunctivitis; blepharitis; purulent ulcers of the cornea; gonorrheal eye diseases in newborns and adults; for the prevention of blenorrhea in newborns.
Directions for use and dosage:
Adults are recommended to use a 30% solution. Place 2 drops in both eyes. The frequency of instillations varies from 2-3 to 5-6 times a day. A 20% solution is used to treat children.
Contraindications:
The drug is contraindicated in case of hypersensitivity to sulfonamide drugs.
Side effects:
The drug is well tolerated by patients, but sometimes tissue irritation may occur. In this case, it is necessary to switch to instilling a solution of lower concentration.
Storage conditions:
In a cool place, protected from light.
Tradename:
Sulfacyl sodium.
International nonproprietary name:
sulfacetamide.
Dosage form.
Eye drops.
Compound:
1 ml of solution contains sodium sulfacetamide monohydrate (sodium sulfacyl) 200 mg based on 100% substance;
Excipients: sodium thiosulfate 1 mg; hydrochloric acid solution 1 M to pH 8; water for injections up to 1 ml.
Description. Transparent colorless or slightly yellowish liquid.
Pharmacotherapeutic group.
Antimicrobial agent – sulfanilamide.
ATX code: S01AB04
Pharmacological properties.
Pharmacodynamics.
Sulfacyl sodium has a bacteriostatic effect against gram-positive and gram-negative bacteria - streptococci, pneumococci, gonococci, Escherichia coli, chlamydia, actinomycetes. The mechanism of action of the drug is due to competitive antagonism with para-aminobenzoic acid (PABA) and inhibition of dihydropteroate synthetase, which leads to disruption of the synthesis of tetrahydrofolic acid, necessary for the synthesis of purine and pyrimidine bases. As a result, the synthesis of nucleic acids (DNA and RNA) of bacterial cells is disrupted.
Pharmacokinetics.
Penetrates into the tissues of the eye, where it exerts its specific antibacterial effect. It acts predominantly locally, but part of the drug is absorbed through the inflamed conjunctiva and enters the systemic bloodstream.
When applied topically, the maximum concentration (Cmax) of sulfonamides in the cornea (about 3 mg/ml), anterior chamber fluid (about 0.5 mg/ml) and iris (about 0.1 mg/ml) is achieved 30 minutes after instillation. A small amount (less than 0.5 mg/ml) of sulfacetamide remains in the tissues of the eyeball for 3-4 hours. If the corneal epithelium is damaged, the penetration of sulfonamides increases.
Indications for use.
As part of complex therapy for children and adults for the treatment of conjunctivitis, blepharitis, purulent corneal ulcers; adults for the treatment of chlamydial and gonorrheal eye diseases. For the prevention and treatment of neonatal blenorrhea.
Contraindications.
History of hypersensitivity to the components of the drug and sulfonamides.
Method of administration and dose.
Adults and children. Instill 1-2 drops of the drug into each conjunctival sac 4-6 times a day.
For the prevention of blenorrhea in newborns. Instill 2 drops of the drug into each conjunctival sac immediately after birth and 2 drops after 2 hours.
Side effect.
Local allergic reactions, short-term burning sensation, blurred vision, lacrimation, pain, itching in the eyes.
Overdose.
Not described.
Interaction with other drugs.
Sulfacetamide enhances the effect of indirect anticoagulants. Combined use with novocaine, dicaine, procaine, tetracaine, anesthesin reduces the bacteriostatic effect of sulfacetamide. Difenin, PAS, salicylates increase its toxicity. Sulfacetamide is incompatible with silver salts.
Special instructions.
In patients with hypersensitivity to furosemide, thiazide diuretics (hydrochlorothiazide), sulfonylureas (glibenclamide), carbonic anhydrase inhibitors (diacarb), cross-sensitivity to sulfacetamide may occur.
Use during pregnancy and breastfeeding.
There is not enough experience with the use of the drug during pregnancy or breastfeeding. It is possible to use sulfacetamide for the treatment of pregnant women and nursing mothers as prescribed by the attending physician, if the expected benefit to the mother outweighs the potential risk to the fetus and child.
The ability to influence reaction speed when driving vehicles and other mechanisms.
Due to the possibility of side effects (lacrimation, blurred vision) after using the drug, you should refrain from driving vehicles or working with complex mechanisms.
Release form.
Eye drops 20%. 5 ml or 10 ml in polyethylene bottles, sealed with caps. Each bottle, along with instructions for medical use, is placed in a cardboard pack.
Storage conditions.
Store in a place protected from light at a temperature of 8 to 15 °C.
Keep out of the reach of children.
Best before date:
2 years. After opening the bottle, the drug is good for 28 days.
Do not use after the expiration date stated on the packaging.
Vacation conditions:
over the counter.
Manufacturer/Marketing Authorization Holder:
PJSC "Farmak", Ukraine, 04080, Kyiv, st. Frunze, 63.
Organization receiving consumer complaints:
Representative office of the Public Joint Stock Company "Farmak" (Ukraine).
Russia, 121357, Moscow, Kutuzovsky prosp., 65.
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