In this article you can read the instructions for use of the drug Panangin. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Panangin in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Panangin in the presence of existing structural analogues. Use for the treatment of potassium and magnesium deficiency, heart failure and myocardial infarction in adults, children, as well as during pregnancy and lactation.
Panangin- a drug that affects metabolic processes. Source of potassium and magnesium ions.
Potassium and magnesium are intracellular cations that play a major role in the functioning of many enzymes, the interaction of macromolecules and intracellular structures, and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, magnesium, calcium and sodium ions affects myocardial contractility. A low level of potassium and/or magnesium ions in the internal environment can have a proarrhythmogenic effect, predisposing to the development of arterial hypertension, atherosclerosis of the coronary arteries and the occurrence of metabolic changes in the myocardium.
One of the most important physiological functions of potassium is maintaining the membrane potential of neurons, myocytes and other excitable structures of myocardial tissue. An imbalance between the intra- and extracellular potassium content leads to a decrease in myocardial contractility, the occurrence of arrhythmia, tachycardia and increased toxicity of cardiac glycosides.
Magnesium is a cofactor in more than 300 enzymatic reactions in energy metabolism and the synthesis of proteins and nucleic acids. Magnesium reduces contractile tension and heart rate, leading to a decrease in myocardial oxygen demand. Magnesium has an anti-ischemic effect on myocardial tissue. Decreased contractility of smooth muscle myocytes in the walls of arterioles, incl. coronary, leads to vasodilation and increased coronary blood flow.
The combination of potassium and magnesium ions in one preparation is justified by the fact that potassium deficiency in the body is often accompanied by magnesium deficiency and requires simultaneous correction of the content of both ions in the body. With simultaneous correction of the levels of these electrolytes, an additive effect is observed, in addition, potassium and magnesium reduce the toxicity of cardiac glycosides without affecting their positive inotropic effect.
Pharmacokinetics
When taken orally, absorption of the drug is high. Excreted in urine.
Data on the pharmacokinetics of the drug in the form of a solution for intravenous administration are not provided.
Indications
- as part of complex therapy for heart failure, myocardial infarction, cardiac arrhythmias (mainly ventricular arrhythmias);
- to improve the tolerability of cardiac glycosides;
- replenishment of potassium and magnesium deficiency when their content in the diet is reduced (for tablets).
Release forms
Film-coated tablets.
Solution for intravenous administration (in ampoules for injection).
Instructions for use and dosage
For oral administration
Prescribe 1-2 tablets 3 times a day. The maximum daily dose is 3 tablets 3 times a day.
The drug should be used after meals, because the acidic environment of the stomach contents reduces its effectiveness.
The duration of therapy and the need for repeated courses are determined by the doctor individually.
For intravenous administration
The drug is prescribed intravenously (in a dropper), as a slow infusion. A single dose is 1-2 ampoules; if necessary, repeated administration can be done after 4-6 hours.
To prepare a solution for intravenous infusion, the contents of 1-2 amps. dissolve in 50-100 ml of 5% glucose solution.
Side effect
- paresthesia (caused by hyperkalemia);
- hyporeflexia;
- convulsions (due to hypermagnesemia);
- AV block;
- paradoxical reaction (increased number of extrasystoles);
- decrease in blood pressure;
- redness of the facial skin (due to hypermagnesemia);
- nausea, vomiting;
- diarrhea (including those caused by hyperkalemia);
- a feeling of discomfort or burning in the pancreas (in patients with anacid gastritis or cholecystitis);
- respiratory depression (due to hypermagnesemia);
- feeling of heat (due to hypermagnesemia);
- with rapid intravenous administration, symptoms of hyperkalemia and/or hypermagnesemia may develop.
Contraindications
For oral and intravenous administration
- acute and chronic renal failure;
- oliguria, anuria;
- Addison's disease;
- 2nd and 3rd degree AV block;
- cardiogenic shock (BP<90 мм рт.ст.);
- hyperkalemia;
- hypermagnesemia;
- hypersensitivity to the components of the drug.
For oral administration
- myasthenia gravis;
- 1st degree AV block;
- hemolysis;
- violation of amino acid metabolism;
- acute metabolic acidosis;
- dehydration of the body.
Use during pregnancy and breastfeeding
There are no data on the negative effects of the drug in the form of a solution for intravenous administration during pregnancy and lactation (breastfeeding).
The drug should be used orally with caution during pregnancy (especially in the 1st trimester) and during lactation (breastfeeding).
special instructions
The drug should be prescribed with caution to patients with an increased risk of developing hyperkalemia. In this case, it is necessary to regularly monitor the level of potassium ions in the blood plasma.
Before taking the drug, the patient should consult a doctor.
With rapid intravenous administration of the drug, skin hyperemia may develop.
Impact on the ability to drive vehicles and operate machinery
The drug does not affect the ability to drive a car or engage in activities that require increased concentration and speed of psychomotor reactions.
Drug interactions
When used simultaneously with potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporine, heparin, ACE inhibitors, NSAIDs, the risk of developing hyperkalemia up to the appearance of arrhythmia and asystole increases. The use of potassium supplements together with corticosteroids eliminates the hypokalemia they cause. Under the influence of potassium, a decrease in the undesirable effects of cardiac glycosides is observed.
The drug enhances the negative dromo- and bathmotropic effects of antiarrhythmic drugs.
Due to the presence of potassium ions in the drug, when Panangin is used with ACE inhibitors, beta-blockers, cyclosporine, potassium-sparing diuretics, heparin, NSAIDs, the development of hyperkalemia is possible (monitoring the level of potassium in the blood plasma is necessary); with anticholinergic drugs - a more pronounced decrease in intestinal motility; with cardiac glycosides - a decrease in their effect.
Magnesium preparations reduce the effectiveness of neomycin, polymyxin B, tetracycline and streptomycin.
Anesthetics enhance the inhibitory effect of magnesium on the central nervous system. When used with atracurium, dexamethonium, suxamethonium, neuromuscular blockade may be enhanced; with calcitriol - increasing the level of magnesium in the blood plasma; with calcium supplements, a decrease in the effect of magnesium ions is observed.
When Panangin is used simultaneously with potassium-sparing diuretics and ACE inhibitors, the risk of developing hyperkalemia increases (the level of potassium in plasma should be monitored).
Analogues of the drug Panangin
Structural analogues of the active substance:
- Asparkam;
- Asparkam-L;
- Asparkam-UBF;
- Asparkam-Farmak;
- Potassium and magnesium aspartate Berlin-Chemie;
- Pamaton.
If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.
Panangin is a combination drug that contains magnesium and potassium salts. This drug actively regulates metabolic reactions and electrolyte balance, restores metabolic processes, has an antiarrhythmic effect, and normalizes metabolism in the myocardium. It is thanks to this property that the drug “Panangin” has found application in the treatment of the cardiovascular system and related diseases.
Mechanism of action of the drug
The complex intake of magnesium, potassium, calcium and sodium ions in the cells and in the extracellular space ensures normal functioning. If the body's metabolism is disturbed and there is a deficiency of magnesium and potassium ions inside the cells of the heart muscle, then this can lead to disturbances in the rhythm of cardiac activity and to increased performance blood pressure, metabolic disorders in the myocardium, the development of ischemic heart disease, as well as increased toxicity of cardiac drugs - glycosides.
Taking the drug "Panangin" gives the body an additional opportunity to receive magnesium ions to participate in the synthesis of proteins and obtain additional energy from carbohydrates. The normal content of magnesium ions in the cells of the heart muscle allows the heart muscle to contract less frequently. This leads to a decrease in the need for oxygen and a reduction in angina attacks. Under the influence of magnesium ion, small blood vessels dilate and blood flow increases. Magnesium and potassium ions are vital for the functionality of the heart muscle; the mechanism of action of the drug "Panangin" is based on this. Contraindications to taking the medicine are based on the activity of magnesium and potassium ions. If there are large quantities of them, this drug should not be taken.
For the treatment of heart diseases and in case of insufficient content of magnesium and potassium salts in food, patients are prescribed the drug "Panangin". Indeed, as the main enzymes, these salts take part in the biochemical reaction of metabolism in the patient’s body.
How to take Panangin?
The medication is taken in tablet form three times a day, two tablets. Preventive therapy is carried out one tablet three times a day. The course of treatment lasts 3-4 weeks. The medicine "Panangin" is administered intravenously as a solution by drip, at a rate of 20-25 drops per minute, once or twice a day, 300 ml.
Panangin: contraindications
Contraindications for the use of the drug are:
Myasthenia gravis,
Severe kidney diseases with impairment of their functions,
Increased levels of magnesium and potassium in the body,
Heart blockades,
Hemolytic anemia,
Adrenal insufficiency,
Severe course of any disease,
Panangin, whose use is contraindicated during pregnancy and breastfeeding, is prescribed to women of childbearing age with caution.
Contraindications to its use apply to patients with intolerance to sorbitol and fructose. If there is a violation of amino acid metabolism, exicosis, hemolysis, dehydration, or pathology of the renal system, taking this drug is not recommended.
The drug "Panangin": side effects
Deterioration of the intestinal mucosa, epigastric pain, bleeding from diarrhea, decreased blood pressure, nausea, itching, thrombosis, dizziness, sweating, asthenia - all these diseases can become side effects when using the drug "Panangin". The appearance of hypermagnesemia and hyperkalemia can provoke rapid intravenous infusion of the drug.
In case of an overdose of the drug, paresthesia of the extremities and changes in readings on the electrocardiogram may occur. In this case, urgent use of dextrose or immediate medical attention is required. In emergency cases, hemodialysis and dialysis are used.
Contraindications
The medicine has a large list of restrictions, so be sure to read the instructions before using it. There are several common cases for both forms of release of the drug, but each of them also has a number of individual contraindications. The table describes them in more detail:
Pills
hyperkalemia;
hypermagnesemia;
acute or chronic kidney failure;
severe myasthenia gravis;
hypersensitivity to the components of the drug;
cardiogenic shock with blood pressure less than 90 mmHg
dehydration.
AV blockade 1-3 degrees
AV blockade 2-3 degrees
Amino acid metabolism disorder
Lactation
Adrenal insufficiency
Acute metabolic acidosis
Pregnancy
Carefully
Pregnancy (especially the first trimester)
Lactation
1st degree AV block
Impaired renal function
Inability to control plasma magnesium levels
Metabolic acidosis
Severe liver dysfunction
Hypophosphatemia
Urolithiasis due to impaired metabolism of calcium, magnesium and ammonium phosphate
Analogues of the drug Panangin
What is the difference between Panangin and Asparkam, Aspangin - domestic analogues? Panangin is an original drug, more purified. Asparkam is an analogue (copy) of this medicine. Tablets of the drug, coated with a protective coating, protect the gastrointestinal tract from negative effects, so people suffering from colitis, ulcers and gastritis should give it preference.
The price indications of the drugs also differ: being a copy, asparkam and aspangin cost two to three times less than the original. Most people who have indications for the use of drugs that replenish K and Mg deficiency give preference to panangin due to its noticeable effect on the heart muscle, leg muscles, and a reduction in the manifestations of varicose veins.
pharmachologic effect
Panangin affects myocardial metabolism and is a source of magnesium and potassium ions (see all potassium and magnesium tablets).
These microelements are intracellular cations and play a leading role in the functioning of a number of enzymes, provide communication between the intracellular structures of the heart muscle and macromolecules, and also participate in the process of muscle contractility. Normal contractile function of the heart is possible with a physiological extra- and intracellular ratio of magnesium, sodium, potassium and calcium ions.
Endogenous aspartate works as an ion conductor. High affinity for cells, possible due to the low dissociation of its salts, ensures the penetration of ions in the form of complex compounds into the cell wall. Magnesium and potassium aspartate have a positive effect on metabolism in the myocardium. The lack of these ions is a predisposing factor in the development of atherosclerosis of the heart arteries, arterial hypertension and metabolic disorders.
- Potassium performs one of the most important physiological functions - it is involved in maintaining the membrane potential of muscle and nerve cells and other myocardial structures with excitability. When the balance of intra- and extracellular potassium content is disturbed, the contractile function of the myocardium decreases, arrhythmia and tachycardia occur, and the toxicity of cardiac glycosides taken in therapeutic doses increases.
- Magnesium is a cofactor in about three hundred enzymatic reactions, including the synthesis of nucleic acids, proteins and energy metabolism. The trace element improves muscle contractile function and normalizes heart rate, reducing the heart's need for oxygen. Magnesium also eliminates ischemia of the heart muscle.
Why is taking a complex drug more effective than taking microelements separately? The fact is that potassium deficiency is almost always accompanied by magnesium deficiency, so it is most rational to carry out a comprehensive correction of microelement deficiency. Simultaneous elimination of the pathological deficiency of potassium and magnesium leads to an additive effect (the effectiveness of the joint action is equal to the sum of the effects of each element separately). Another positive joint effect is a reduction in the toxicity of cardiac glycosides without inhibiting their inotropic effect.
Who is the drug prescribed to?
For those who do not know what Panangin tablets are for, it is worth saying that they are prescribed to compensate for the deficiency of magnesium and potassium, provided that their content in the diet is low.
Less commonly, the tablet form of the drug can be recommended for use by patients as part of the complex treatment of arrhythmia, heart failure and acute myocardial infarction. In most cases, people with such diseases are prescribed the medicine "Panangin" in the form of a solution for intravenous administration.
Panangin solution or tablets are prescribed (the instructions also contain this information) to people suffering from various heart diseases. This is due to the fact that potassium and magnesium ions improve the tolerance of cardiac glycosides.
pharmachologic effect
The drug Panangin is a source of magnesium and potassium and affects metabolic processes in the body. These microelements are extremely valuable substances for the proper functioning of a wide variety of processes in the body, including the healthy functioning of all internal organs and the cardiovascular system in particular.
Potassium and magnesium are directly involved in the functioning of various enzymes, are involved in the interaction of macromolecules and intracellular structures, as well as in the action of the mechanism of muscle contractility. These microelements are especially necessary for proper contractile function of the myocardium. With a long-term deficiency of magnesium and potassium ions in the body, arterial hypertension, atherosclerosis of the coronary arteries, and metabolic changes in the myocardium may develop. One of the most significant physiological functions of potassium is the preservation of the membrane potential of neurons and various excitable structures of myocardial tissue. Prolonged lack of potassium in the body leads to increased toxicity of cardiac glycosides and the occurrence of arrhythmia and tachycardia.
No less valuable for the body is magnesium, which is a cofactor in about 300 enzymatic metabolic reactions of energy metabolism and the production of nucleic acids and proteins. Due to magnesium, the heart rate and myocardial muscle tension are partially reduced, and magnesium also produces an anti-ischemic effect on myocardial tissue.
Both of these microelements are interconnected and that is why potassium and magnesium ions are combined in one preparation. The fact is that potassium deficiency is often accompanied by a lack of magnesium, and to compensate for such a deficiency, a simultaneous intake of both ions into the body is required. Simultaneous correction of the levels of these electrolytes leads to an additive effect; it also reduces the toxicity of cardiac glycosides without suppressing their positive inotropic effect.
7 Analogues of the product
Popular analogues of Panangin are Asparkam, potassium and magnesium aspartate. These drugs are similar in action, properties and a number of side effects on the human body. A group of similar drugs includes Aspangin, Pamaton. Each drug has its own characteristics, so you cannot replace one with another on your own.
A popular analogue of Panangin is Asparkam, which is familiar to many patients. Its production began many years ago and for a long period of time had no corresponding analogues. Russian Asparkam has an identical composition to Panangin, but costs much less. However, not all so simple. Experts say that Asparkam is worse for the heart than Panangin.
It is important to store Panangin correctly. It must be kept at a temperature not exceeding 30°C
The shelf life established by the manufacturer does not exceed 5 years, and for the liquid form - 3 years. Children should not be allowed to accidentally use the medicine. Consultation with a specialist is required.
Despite the fact that Panangin can be purchased without a prescription, independent use is undesirable. This is due to the fact that a person may not realize that he has an individual intolerance or contraindications for using this drug.
Panangin is a medicine; it does not belong to the category of vitamins or dietary supplements, so you cannot drink it just like that. In order to maintain good health, you need to regularly visit a doctor and undergo an annual medical examination. Do not neglect the rules of safety and prevention of cardiovascular diseases.
The cost of the drug varies depending on the pharmacy and region of the country, but it does not exceed 200 rubles. The price of tablets and injections differs, this is due to the form of release and production technology. The injections are stronger, and the tablets are less aggressive in treatment. The treatment and necessary medications are selected by the attending physician. If necessary, you can replace Panangin with analogues and generics. For example, this is done if an allergy or intolerance to the components of the product occurs.
Drug interactions
- In combination with ACE inhibitors, potassium-sparing diuretics, cyclosporine, beta-blockers, NSAIDs, heparin, the risk of developing hyperkalemia increases.
- In combination with glucocorticosteroids, hypokalemia, which is a side effect of hormonal therapy, is eliminated.
- In combination with cardiac glycosides, their toxicity is reduced.
- When taken together with antiarrhythmic drugs, their negative dromo- and bathmotropic effects are enhanced.
- Reduced effects of neomycin, tetracycline, polymyxin B and streptomycin.
- Calcium reduces the effect of magnesium in Panangin.
- When used with anesthetics, the inhibitory effect of magnesium on the central nervous system increases.
- Atracurium, Dexamethonium and Suxamethonium may lead to increased neuromuscular blockade.
- Calcitroiol increases plasma magnesium levels.
- Astringent and enveloping drugs reduce the absorption of Panangin from the gastrointestinal tract.
How it works
Panangin promotes the proper functioning of many systems.
Potassium and magnesium, which are contained in this medicine, have the following effects on the body:
- restoration of electrolyte balance;
- improvement of myocardial metabolism;
- antiarrhythmic effect;
- Helps maintain normal cardiac activity.
One way or another, many people suffer from a deficiency of these elements. The stronger the deficiency, the higher the risk of developing hypertension, atherosclerosis and myocardial changes.
The effect of the medicinal supplement occurs within a few weeks after the start of use. A person begins to feel better and gets rid of heart pain.
The functioning of the entire body as a whole improves significantly. The activity of many systems is returning to normal.
Instructions for use of Panangin in ampoules
The dosage and method of administration must be prescribed by a doctor. It may be enough for some to take pills, but with injections, magnesium and potassium will be better absorbed, and the results will appear faster. That’s why “Panangin” is administered intravenously so that the active substances enter the blood immediately. To do this, you need to dilute the contents of 1 ampoule of the drug with 50 ml of a 5% glucose solution. The injection is done by drip so that the drug enters the blood gradually (no faster than 20 drops per minute). Otherwise, the risk of side effects increases. You can repeat the drip after 4-6 hours. Usually 1-2 ampoules of Panangin are administered at a time.
Medicine Panangin
The preparation is based on 2 microelements – magnesium and potassium ions. Due to them, the medicine normalizes heart rhythm, further improving the conduction of nerve impulses through the conduction system of the heart. Restoring ion levels by eliminating magnesium and potassium deficiency helps with heart rhythm disturbances. Such effects help in the treatment or prevention of atherosclerosis and myocardial infarction. Panangin - instructions for its use indicate that it is part of a combination therapy against the occurrence of arrhythmia or chronic heart diseases.
Compound
Regardless of the form of release, the main substances of the drug are potassium and magnesium. The composition contains auxiliary components. They are different for tablets and solution, in the form of which the drug is produced. The table describes the composition in more detail:
Release form
Panangin is available in different forms - in the form of an injection solution and tablets for oral administration. The active substances in them are the same, but are contained in different concentrations. In a pharmacy, each form of the drug can be recognized by its special packaging and the type of tablets or solution themselves:
Pharmacodynamics and pharmacokinetics
Magnesium and potassium are very important for the formation of connections between macromolecules and intracellular structures, the preservation of myocardial functions, and muscle contraction. Substances help:
- restore electrolyte balance;
- regulate metabolic processes and reactions;
- prevent the development of arrhythmia due to low levels of potassium and magnesium.
Potassium is an integral part of synaptic transmission, the implementation of muscle contractions. Its aspartate improves the conduction of nerve impulses. Additionally, the microelement has a diuretic effect. Magnesium is part of the reactions and processes responsible for energy expenditure. It promotes the penetration of potassium ions into cells. Medicine based on them improves myocardial metabolism. According to the instructions for use, the drug is well absorbed and excreted by the kidneys.
Indications for use
The main indication for use is to compensate for the deficiency of potassium and magnesium in the body. This is necessary for cardiovascular pathologies or the development of their complications. Specific indications, according to the instructions, are:
- heart failure;
- hypomagnesemia and hypokalemia with low magnesium content or lack of potassium in the diet;
- taking laxatives and diuretics, glucocorticosteroids;
- persistent vomiting, diarrhea;
- taking saluretics that enhance sodium excretion;
- acute myocardial infarction;
- digitalis intoxication;
- atrial extrasystole;
- paroxysmal tachycardia;
- supraventricular tachycardia;
- ventricular extrasystole.
What does the medicine help with Panangin?
What is the mechanism of action of panangin when the patient has indications for using the medicine? Microelements necessary for the normal functioning of the cardiovascular system perform the following functions:
- Stimulate myocardial function, increasing cardiac conduction of impulses.
- Strengthen the walls of blood vessels, reducing muscle tone and increasing blood flow.
- Normalizes heart rate.
- Participate in the metabolic processes of the heart, relieve swelling and spasms of internal organs.
For preventive purposes, cardiologists prescribe panangin to patients:
- when there is a threat of ischemia;
- after a heart attack;
- people suffering from heart pain, swelling;
- for heart failure, arrhythmias;
- high blood pressure, hypertension.
Indications for the use of panangin are constant spasms and pain in the leg muscles. The lack of active substances leads to a “squeezed” state of the muscular system and constant contraction. Intense physical activity, mental work, stressful situations are prerequisites for potassium and magnesium deficiency. Taking medication in these cases increases performance and increases resistance to stress.
The inclusion of Mg and K in the composition of the drug is due to a simultaneous deficiency of these microelements in the body. Potassium and magnesium ions in combination create additive synergism, when each substance exhibits an effect separately, enhancing the effect of the “companion”. Indications for the use of the drug are to reduce the toxicity of cardiac glycosides without affecting the positive effects.
Drug interactions
- The risk of hyperkalemia increases with simultaneous use of this drug with beta-blockers, potassium-sparing diuretics (spironolactone, triamterene), cyclosporine, ACE inhibitors, heparin and NSAIDs.
- The negative batmo- and dromotropic effects of antiarrhythmic drugs are enhanced; use together with GCS reduces hypokalemia caused by these substances.
- Increased neuromuscular blockade is possible when using the drug Panangin together with atracurium, suxamethonium, dexamethonium.
- Calcium preparations reduce the effect of magnesium ions, and anesthetics increase the inhibitory effect of magnesium on the central nervous system.
1 General information about the medicine
Manufacturers produce Panangin in several forms: in the form of tablets and solution. The liquid intended for intravenous administration is colorless and odorless; a transparent greenish tint is allowed. When examining the contents, no grains should be detected in the solution. The drug contains 45.2 mg of potassium aspartate per 1 ml of liquid.
The drug is packaged in a plastic shell, five ampoules each. To reduce the cost of production, cardboard packaging is used. The drug, which is available in tablet form, has a color ranging from white to off-white. All tablets are coated with an enteric film, which makes the appearance of the medicine shiny and uneven.
The tablets contain particles of corn starch, talc, potato starch, magnesium stearate, povidone, and silicon dioxide. To film the tablets, talc, titanium dioxide, and macrogol 6000 are used. The tablets are packaged in a bottle of 50 pieces and packed in cardboard boxes.
The work and health of the body, as well as the harmonious functioning of all organs, depend on many factors. The most important of them is maintaining the necessary balance of minerals and trace elements. Potassium and magnesium are actively involved in debugging the functioning of the heart and all blood vessels. By improving the metabolic processes of the heart and myocardial metabolism, these components protect the fragile human body from arrhythmia, heart attack or tachycardia.
Usually a person receives potassium and magnesium from the outside, for example, with food or as special medications. Reviews of Panangin indicate its high effectiveness as a component of complex treatment, as well as as a separate drug for replenishing micronutrient deficiencies.
Composition of Panangin
The drug is a complete medicine that is designed to compensate for the lack of potassium and magnesium in the body. The medicine contains two active substances:
- magnesium aspartate;
- potassium aspartate.
The following are present as auxiliary additives and stabilizers: talc, magnesium stearate, corn starch, enterosorbents. Magnesium and potassium aspartate is considered a medicinal component, which is the ions of the corresponding trace elements. Aspartate, which is part of panangin, is a supplier of potassium and magnesium through cell membranes and helps regulate metabolic processes.
Modern pharmaceutical companies produce:
- solution for intravenous and intramuscular administration;
- pills.
For oral use, Panangin is sold in cardboard packaging. Tablets in the amount of 50 pieces are packed in a plastic bottle. Solution for intravenous administration packaged in glass ampoules of 10 ml each, 5 pieces per package.
Indications for use
Potassium and magnesium, which are so necessary for the patient for the normal functioning of the cardiovascular system, perform the following functions:
As a preventative measure, doctors prescribe Panangin to their patients for the following problems:
- after a heart attack;
- when there is a threat of coronary disease;
- patients suffering from swelling and heart pain;
- for arrhythmia and heart failure;
- for hypertension and high blood pressure.
When a patient is tormented by constant spasms in the leg muscles, the doctor prescribes Panangin. The fact is that it is the lack of potassium and magnesium that leads to a state of muscle tightness and their periodic contraction. Constant physical activity high intensity, stressful situations, mental work - all these are prerequisites for magnesium and potassium deficiency. If you start taking the necessary medications in a timely manner, stress resistance significantly increases and performance increases.
Both components disappear from the body evenly, so these two microelements are contained in Panangin. When combined, the ions create an effect called additive synergism (each element works separately, but enhances the effect of its companion).
Composition of Panangin tablets selected in such a way that each capsule has high absorption and is easily excreted from the body through the kidneys. Sometimes doctors prescribe Panangin tablets in combination with cardiac glycosides.
According to the instructions, the dosage of tablets is prescribed by the attending physician, but, as a rule, does not go beyond two capsules three times a day. If the patient has a violation of coronary circulation, then 2-3 capsules are prescribed three times a day, always after meals. So, under the supervision of the attending physician, the dosage is gradually reduced.
The medicine in the form of a solution for injection into a vein by stream or drip is used exclusively in a medical institution under the supervision of a group of specialists.
Contraindications
Each drug has its own number of contraindications, and Panangin was no exception. A doctor does not prescribe this medicine and you should not buy it yourself if you have the following ailments and conditions:
Panangin is not recommended during the first trimester of pregnancy and lactation. Patients with cardiac muscle conduction pathology should take the drug with caution. If the patient feels a burning sensation in the epidural area, be sure to inform your doctor about this, he will reduce the dosage or prescribe an analogue.
Children should find out about the possibility of prescribing Panangin from a doctor, since a fragile child’s body can perceive even a minimal dose of the drug as an overdose.
The combined use of Panangin and other medications should be discussed with your doctor in advance.
Cases of overdose
If for some reason you were drunk an abnormal dose of the drug, an increase in the symptoms of hyperkalemia and hypermagnesemia may be observed: diarrhea or constipation, nausea, vomiting, lethargy, cramps of the lower extremities, minor dehydration. If an overdose occurs, the following manipulations must be carried out:
- stop taking the drug (before visiting a doctor);
- inject 300 ml of saline solution;
- in particularly severe cases of intoxication, hemodialysis is necessary.
How much does Panangin and its analogues cost?
You can buy the drug in both tablets and ampoules at any pharmacy; a doctor’s prescription is not required. The price of the medicine ranges from 150 to 170 rubles for tablets and from 140 to 170 rubles for a solution for intramuscular injection.
The main generics of the drug are Aspangin and Asparkam. The difference between Panangin and these drugs is that it is a refined product, the original, and Asparkam is its exact copy. Panangin tablets are coated with a special protective coating, which means they do not affect the walls of the gastrointestinal tract, so patients with ulcerative colitis should give preference to Panangin.
There is also an additional version of Panangin, which includes vitamin B6, as well as Panangin Forte. Both drugs are similar in properties to the original. Medicines should be taken correctly, that is, only as prescribed by a doctor.
The price of Aspangin and Asparkam is significantly lower than the cost of the original, but despite this, most patients prefer Panangin. Compared to the copy, the original has a noticeable effect on the leg muscles, heart muscle, reduces swelling and the appearance of varicose veins.
Tradename
Panangin®
Dosage form
COMPOUND
Active ingredients:
Magnesium aspartate 140.0 mg (in the form of magnesium aspartate 4 H2O – 175.00 mg) and
potassium aspartate 158.0 mg (in the form of potassium aspartate 1/2 H2O – 166.30 mg).
Excipients:
Silicon dioxide, colloidal – 2.00 mg, povidone K30 – 3.30 mg, magnesium stearate – 4.00 mg,
talc – 10.00 mg, corn starch – 86.10 mg, potato starch – 3.30 mg in the core
tablets.
Shell composition:
Macrogol 6000 – 1.40 mg, titanium dioxide Col. ind. 77891, E171 – 5.30 mg,
butyl methacrylate, dimethylaminoethyl methacrylate and methyl methacrylate copolymer
– 6.00 mg, talc – 7.30 mg.
DESCRIPTION
Round, biconvex, film-coated tablets, white or almost white, with a slightly shiny and uneven surface, almost odorless.
Pharmacological group
Potassium and magnesium preparation.
ATX code
PHARMACOLOGICAL PROPERTIES
Pharmacodynamics: the most important intracellular cations K+ and Mg++ play a key role in the functioning of numerous enzymes, in the formation of bonds between macromolecules and intracellular structures and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, calcium, sodium and magnesium ions affects myocardial contractility. Endogenous aspartate acts as a conductor of ions: it has a high affinity for cells, due to the slight dissociation of its salts, ions in the form of complex compounds penetrate into the cells. Magnesium and potassium aspartates improve myocardial metabolism. Lack of magnesium/potassium predisposes to the development of hypertension, atherosclerosis of the coronary arteries, arrhythmia and metabolic changes in the myocardium.
Pharmacokinetics: Absorption is high. Excreted by the kidneys.
INDICATIONS FOR USE
As an additional remedy in the treatment of chronic heart diseases (heart failure, condition after myocardial infarction), heart rhythm disturbances (primarily ventricular arrhythmias), in the treatment of digitalis; replacement therapy for lack of magnesium/potassium in food.
CONTRAINDICATIONS
Hypersensitivity to any of the constituent components of the drug, acute and chronic renal failure, hyperkalemia, hypermagnesemia, Addison's disease, atrioventricular block I-III degree, cardiogenic shock (blood pressure less than 90 mmHg), amino acid metabolism disorder, myasthenia gravis , hemolysis, acute metabolic acidosis, dehydration.
CAREFULLY
Pregnancy (especially in the first trimester) and during lactation.
METHOD OF APPLICATION AND DOSES
Inside, the drug should be used after meals, because. the acidic environment of the stomach reduces its effectiveness.
Usual daily dose: 1-2 tables each 3 times a day.
Maximum daily dose: 3 tablets 3 times a day.
The duration of taking the drug and the need for repeated courses is determined by the doctor.
SIDE EFFECTS
Possible nausea, vomiting, diarrhea, discomfort or burning sensation in the pancreas (in patients with anacid gastritis or cholecystitis), atrioventricular block, paradoxical reaction (increased number of extrasystoles), hyperkalemia (nausea, vomiting, diarrhea, paresthesia), hypermagnesemia (redness of the face, feeling of thirst, decreased blood pressure, hyporeflexia, respiratory depression, convulsions).
OVERDOSE
Symptoms: conduction disturbances (especially with previous pathology of the cardiac conduction system).
Treatment: intravenous administration of calcium chloride; if necessary, hemodialysis and peritoneal dialysis.
INTERACTION WITH OTHER MEDICINES
Pharmacodynamic: combined use with potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporine, heparin, angiotensin-converting enzyme (ACE) inhibitors, non-steroidal anti-inflammatory drugs increases the risk of developing hyperkalemia up to the development of arrhythmia and asystole. The use of potassium supplements together with glucocorticosteroids eliminates the hypokalemia caused by the latter. Under the influence of potassium, the undesirable effects of cardiac glycosides are reduced. Strengthens the negative dromo- and bathmotropic effect of antiarrhythmic drugs. Magnesium reduces the effect of neomycin, polymyxinB, tetracycline and streptomycin. Anesthetics increase the inhibitory effect of magnesium preparations on the central nervous system; when used simultaneously with atracuronium, decamethonium, succinyl chloride and suxamethonium, neuromuscular blockade may be enhanced; Calcitriol increases the content of magnesium in the blood plasma, calcium supplements reduce the effect of magnesium supplements.
Pharmacokinetic: astringents and enveloping agents reduce the absorption of the drug in the gastrointestinal tract and it is necessary to maintain a three-hour interval between ingestion of Panangin® with the listed agents.
SPECIAL INSTRUCTIONS
Patients with diseases accompanied by hyperkalemia require special attention: regular monitoring of the ionogram is necessary.
Impact on the ability to drive a car and perform work associated with an increased risk of injury: does not affect the ability to drive a car and engage in activities that require increased concentration and speed of psychomotor reactions.
RELEASE FORM
Film-coated tablets.
50 tablets in a polypropylene bottle. 1 bottle in a cardboard box with instructions for use.
STORAGE CONDITIONS
At a temperature of 15-30 °C. Keep out of the reach of children.
BEST BEFORE DATE
5 years. Do not use the drug after the expiration date.
CONDITIONS OF VACATION FROM PHARMACIES
Over the counter.
MANUFACTURER
JSC "Gedeon Richter"
JSC "GEDEON RICHTER - RUS"
140342 Russia, Moscow region, Egoryevsky district,
Shuvoe village, st. Lesnaya, 40
In the case of packaging and packaging of the drug, JSC "GEDEON RICHTER - RUS" additionally indicates:
Packaged/Packed at JSC "GEDEON RICHTER - RUS"
140342 Russia, Moscow region, Egoryevsky district, Shuvoe village, st. Lesnaya, 40
Tel.: (495) 363–3950, Fax: (495) 363–3949
Download instructions
Registration number
Tradename
Panangin® Forte
International or group name:
Potassium aspartate + magnesium aspartate.
Dosage form
Film-coated tablets.
Composition per tablet
Tablet core
Active ingredients:
potassium aspartate 316.00 mg (in the form of potassium aspartate hemihydrate 332.60 mg),
magnesium aspartate 280.00 mg (in the form of magnesium aspartate tetrahydrate 350.00 mg);
Excipients: corn starch 172.20 mg, talc 20.00 mg, magnesium stearate 8.00 mg, potato starch 6.60 mg, povidone K30 6.60 mg, colloidal silicon dioxide 4.00 mg;
Tablet shell: talc 7.30 mg, butyl methacrylate copolymer 6.00 mg, titanium dioxide (color index: C.I. 77891, E171) 5.30 mg, macrogol-6000 1.40 mg.
Description
Oval, biconvex, film-coated tablets, white or almost white, with a slightly glossy surface, engraved “A83” on one side, almost odorless. On a cross section it is white or almost white in color.
Pharmacotherapeutic group
Potassium and magnesium preparation.
ATX code
Pharmacological properties
Pharmacodynamics. The most important intracellular cations of potassium (K+) and magnesium (Mg++) play a key role in the functioning of numerous enzymes, in the formation of bonds between macromolecules and intracellular structures and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, calcium, sodium and magnesium ions affects myocardial contractility.
Endogenous aspartate acts as a conductor of ions: it has a high affinity for cells, due to the slight dissociation of its salts, ions in the form of complex compounds penetrate into the cell. Magnesium aspartate and potassium aspartate improve myocardial metabolism. Lack of magnesium/potassium predisposes to the development of arterial hypertension, atherosclerosis of the coronary arteries, arrhythmias and metabolic changes in the myocardium.
Each tablet of the drug Panangin® Forte contains 280 mg of magnesium aspartate and 316 mg of potassium aspartate, which is 2 times higher than the content of active ingredients in the drug Panangin®, film-coated tablets.
Daily dose of Panangin® Forte.
1 tablet 3 times a day, corresponds to the daily dose of Panangin®: 2 tablets 3 times a day. Taking a single dose of Panangin® Forte in the form of one tablet makes treatment more convenient for the patient.
Pharmacokinetics. Potassium and magnesium aspartates are intensively absorbed in the intestine, mainly in the small intestine. Excreted by the kidneys.
Indications for use
To eliminate potassium and magnesium deficiency as part of combination therapy for various manifestations of coronary heart disease (including acute myocardial infarction); chronic heart failure; heart rhythm disturbances (including arrhythmias caused by an overdose of cardiac glycosides).
Contraindications
Hypersensitivity to any of the constituent components of the drug, acute and chronic renal failure, hyperkalemia, hypermagnesemia, Addison's disease, atrioventricular block I-III degree, shock (including cardiogenic) (blood pressure less than 90 mm Hg), metabolic disorders amino acids, myasthenia gravis, hemolysis, acute metabolic acidosis, dehydration state, age under 18 years (efficacy and safety have not been established).
Carefully
Pregnancy (especially in the first trimester of pregnancy) and the period of breastfeeding.
Use during pregnancy and breastfeeding
Use is possible if the potential benefit to the mother outweighs the possible risk to the fetus.
Potassium and magnesium aspartate pass into breast milk. If it is necessary to take the drug during breastfeeding, breastfeeding should be stopped.
Directions for use and doses
Before use, you should consult your doctor.
Take orally, without chewing and with plenty of water.
Panangin® Forte should be taken after meals, because... the acidic environment of the stomach reduces its effectiveness.
Recommended daily dose: 1 tablet 3 times a day.
Maximum daily dose: 1 tablet 3 times a day.
Side effect
Possible nausea, vomiting, diarrhea, discomfort or burning sensation in the epigastric region (in patients with anacid gastritis or cholecystitis), atrioventricular block, paradoxical reaction (increased number of extrasystoles), hyperkalemia (nausea, vomiting, diarrhea, paresthesia), hypermagnesemia (redness of the face , feeling of thirst, decreased blood pressure, hyporeflexia, respiratory depression, convulsions).
If any of the side effects listed become serious, or you notice side effects not listed in this leaflet, you should consult your doctor.
Overdose
The risk of symptoms of hyperkalemia and hypermagnesemia increases.
Symptoms of hyperkalemia: increased fatigue, myasthenia gravis, paresthesia, confusion, heart rhythm disturbances (bradycardia, atrioventricular block, arrhythmias, cardiac arrest).
Symptoms of hypermagnesemia: decreased neuromuscular excitability, nausea, vomiting, lethargy, decreased blood pressure. With a sharp increase in the content of magnesium ions in the blood: inhibition of deep tendon reflexes, respiratory paralysis, coma.
Treatment: symptomatic therapy - intravenous administration of calcium chloride at a dose of 100 mg/min, if necessary - hemodialysis.
Interaction with other drugs
Pharmacodynamic interaction
When used together with potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporine, heparin, angiotensin-converting enzyme (ACE) inhibitors, and non-steroidal anti-inflammatory drugs, the risk of developing hyperkalemia up to the development of arrhythmia and asystole increases. The simultaneous use of potassium supplements with glucocorticosteroids eliminates the hypokalemia caused by the latter. Potassium reduces the undesirable effects of cardiac glycosides. Panangin® Forte enhances the negative dromo- and bathmotropic effects of antiarrhythmic drugs. Magnesium reduces the effects of neomycin, polymyxin B, tetracycline and streptomycin. Anesthetics increase the inhibitory effect of magnesium preparations on the central nervous system; when used simultaneously with atracuronium, decamethonium, succinyl chloride and suxamethonium, neuromuscular blockade may be enhanced. Calcitriol increases the content of magnesium in the blood plasma, calcium supplements reduce the effects of magnesium supplements.
Pharmacokinetic interaction
Medicines that have an astringent and enveloping effect reduce the absorption of magnesium aspartate and potassium aspartate in the gastrointestinal tract, therefore it is necessary to maintain a three-hour interval between oral administration of Panangin® Forte with the above medications.
special instructions
Patients with diseases accompanied by hyperkalemia require special attention: regular monitoring of potassium levels in the blood plasma is necessary.
Impact on the ability to drive vehicles and machinery
No studies have been conducted. No effect is expected on the ability to drive vehicles or operate mechanisms that require increased concentration and speed of psychomotor reactions.
Release form
Film-coated tablets, 316 mg + 280 mg.
Keep out of the reach of children!
Do not use after the expiration date stated on the package.
Name and address of the legal entity in whose name the registration certificate was issued:
JSC "Gedeon Richter"
1103 Budapest, st. Demrei 19-21, Hungary
Manufacturer
JSC "Gedeon Richter"
1103 Budapest, st. Demrei 19-21, Hungary
15 tablets in a blister made of PVC/PVDC and aluminum foil. 2, 4, 6 blisters along with instructions for use are placed in a cardboard box.
Storage conditions
At a temperature not exceeding 30 °C.
Best before date
2 years.
Vacation conditions
Available without a prescription.
Consumer complaints should be sent to:
Moscow Representative Office of JSC Gedeon Richter
119049 Moscow, 4th Dobryninsky lane, building 8,
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Certificate of state registration
No. RU.77.99.11.003.E.002001.02.15 dated 02/04/2015
Tradename
Plus Vitamin B6 "Panangin"®
Release form
tablets weighing 545 mg
Composition (1 tablet)
Active components: magnesium aspartate tetrahydrate (magnesium aspartate 140 mg), potassium aspartate hemihydrate (potassium aspartate 158 mg), pyridoxine hydrochloride (vitamin B6 0.6 mg).
Excipients: media microcrystalline cellulose, agent anti-firing talc, shell Euragin E-100, thickening polyvinylpyrrolidon (povidon), agent anti-firing magnesium stearat, thickening starch potatoes, glazing agent polyethylene glycol 6000 (macrogol 6000), agent anti-olive diox dioxide, dyeing diox Sid, baking powder Crospovidon.
Application area: recommended as a biologically active food supplement - an additional source of vitamin B6, containing magnesium aspartate and potassium aspartate.
Energy value: 0 kcal.
The nutritional value: proteins 0 g, fats 0 g, carbohydrates 0 g
The properties of the product are determined by the complex of properties of the active components included in its composition.
Vitamin B6 (pyridoxine)
Vitamin B6 (pyridoxine) is involved in a wide range of metabolic processes:
- participates in the regulation of the nervous system
- exhibits anti-stress and antidepressant effects;
- improves the absorption of magnesium in the gastrointestinal tract and facilitates the transport of magnesium ions into cells;
- has a positive effect on liver function, hematopoiesis, and energy metabolism (synthesis of ATP molecules);
- improves the body's use of unsaturated fatty acids, including those that prevent the development of atherosclerosis, have a cardioprotective effect and reduce cholesterol levels.
Vitamin B6 (pyridoxine) deficiency occurs when the body's increased need for it (during heavy physical activity, pregnancy, excess protein in the diet) and is often accompanied by magnesium deficiency. A decrease in vitamin B6 levels may be accompanied by irritability, lethargy, decreased appetite and nausea.
Magnesium
Magnesium is a vital element that is found in all tissues of the body and is necessary for the normal functioning of cells. Actively participates in more than 300 enzymatic processes:
- is a mandatory element for the regulation of the transmission of nerve impulses and the stable functioning of the nervous system;
- able to increase the body’s resistance to psycho-emotional stress;
- has a calming effect; reduces the level of anxiety, nervousness, irritability;
- has a positive effect on vascular tone, conductivity, excitability and contractility of the myocardium;
- helps reduce cholesterol levels in the blood and tissues and prevent cholesterol deposition in the artery wall;
- helps normalize blood clotting and bone metabolism.
The causes of magnesium deficiency in the body can be acute and chronic stress, physical overexertion and physical inactivity, alcohol abuse, low-calorie diets, pregnancy and lactation.
A decrease in magnesium levels can develop when exposed to high temperatures (hot climate, work in hot shops, excessive visits to saunas and baths); when eating foods with limited magnesium content or foods that interfere with the absorption of magnesium in the gastrointestinal tract (high content of animal fats, proteins, phosphorus, calcium); for diseases of the gastrointestinal tract, diabetes mellitus, chronic heart failure, obesity. Depletion of intracellular magnesium stores causes adverse effects on the myocardium (heart muscle).
Magnesium deficiency is accompanied by impaired cardiac conduction, increases the risk of arrhythmia, predisposes to spasm of the coronary arteries, promotes the development of insomnia, autonomic dystonia syndrome, arthritis, migraine, and osteoporosis.
Magnesium is a vital macronutrient for potassium absorption and optimal intracellular K+ levels.
Potassium
Potassium is the main element of every living cell:
- regulates intracellular exchange of water and salts;
- promotes the removal of water and sodium from the body;
- participates in the conduction of nerve impulses to muscles, normalizes muscle contraction;
- activates a number of enzymes and participates in the processes of energy formation, synthesis of proteins and carbohydrates.
The reason for a decrease in the level of potassium in the body can be the use of certain medications (diuretics, hormonals, caffeine), diarrhea and vomiting, and excessive sweating.
Potassium deficiency is characterized by clinical symptoms similar to asthenia (a feeling of fatigue that persists even after sleep and rest, fatigue, sleep disturbances, anxiety, depression). Also characteristic symptoms of potassium deficiency are instability of blood pressure, heart rhythm disturbances, and constipation.
The most characteristic signs of a cumulative deficiency of potassium and magnesium: fatigue, decreased performance, muscle weakness, heart rhythm disturbances, insomnia, cramps, painful contractions and spasms of the calf muscles, especially at night or during physical activity, depression.
The intake of magnesium and potassium into the body in the form of organic salts-aspartates promotes the rapid absorption of these elements in the gastrointestinal tract and their entry into cells.
The combined intake of magnesium aspartate, potassium aspartate and vitamin B6 (pyridoxine) helps maintain the functioning of the heart and blood vessels under stress due to:
- normalization of the tone of the heart muscle and blood vessels, blood pressure and heart rate;
- reducing the risk of developing atherosclerosis;
- increasing stress resistance;
- improving the functioning of the nervous system; reducing anxiety.
1103 Budapest, st. Demrei, 19-21, Hungary.
Importer in the Russian Federation:
JSC "GEDEON RICHTER - RUS", 140342 Russia, Moscow region,
Egoryevsky district, Shuvoe village, st. Lesnaya, 40.
Consumer complaints should be sent to:
Moscow Representative Office of JSC Gedeon Richter
119049 Moscow, 4th Dobryninsky lane, building 8,
Tel.: (495) 363–39–50, Fax: (495) 363–39–49
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