Candida cream during pregnancy for external use. Candida: a cure for fungus. Preventive actions on facial skin

Candide: instructions

The instruction accompanies any form of release of the drug Candide by applying information directly to the packaging of the drug.

Form, composition, packaging

The drug Candide comes in several dosage forms.

Cream Candide for external use in the form of a homogeneous substance in aluminum tubes of 20 grams. White color.

Clotrimazole, being an active component of the drug, is supplemented with white petrolatum, sodium dihydrogen phosphate, propylene glycol, sodium hydrogen phosphate, color macrogol emulsion wax, benzyl alcohol, liquid paraffin, methyl parahydroxybenzoate, butylated hydroxytoluene, propyl parahydroxybenzoate and purified water.

Candida powder for external use in the form of powder in a plastic bottle of thirty grams.

Candide solution transparent, topically applied, viscous consistency and colorless. The drug is packaged in bottles containing 15 grams of the product. The active ingredient of the composition, clotrimazole, is supplemented with glycerol and propylene glycol in the required proportions.

Candide tablets/suppositories for intravaginal use. Clotrimazole in their composition is combined with an additive in the form of a combination of purified talc, sodium carboxymethyl starch, starch, methyl parahydroxybenzoate, magnesium stearate, propylparaben, silicon dioxide and lactose.

Storage period and conditions

Candide in any of its varieties is stored for about three or four years away from children in a temperature range of 2 to 25 degrees.

Pharmacology

The drug is capable of exhibiting local antifungal (in a wide spectrum) and antibacterial, as well as antiprotozoal action. Shows excellent effect against gram (+) bacteria and a range of gram (–) pathogens. The drug is active against the pathogen lichen versicolor.

Pharmacokinetics

The metabolism of clotrimazole occurs in the liver.

Since external application does not lead to absorption, systemic effects are not observed.

The drug administered intravaginally is absorbed by no more than 10%. The next two or three days after use, a small level of concentration of clotrimazole in the blood and a rather high level in the vaginal secretion may be noted.

Candid indications for use

For a number of diseases, it is advisable to use some forms of Candida:

  • in the presence of pityriasis versicolor or versicolor;
  • fungal diaper dermatitis;
  • mycosis of skin folds and feet;
  • development of candidiasis in the genital area and anus;
  • erythrasmas;
  • with paronychia candidiasis;
  • for candidiasis of superficial etiology, which is caused by various fungi and dermatophytes;
  • for skin candidiasis;
  • for mycoses with subsequent complication of pyoderma;
  • with balanitis or candidal vulvitis.

In the form of a solution, the drug is used for the development of candidal stomatitis in the oral cavity.

Vagina tablets are used in the treatment of candidal infections and superinfections of the genital area.

Often the drug is used when preparing a woman for childbirth to sanitize the birth canal.

Contraindications

If a patient has a high degree of sensitivity to the active component of the drug, he cannot be treated with this medicine, regardless of its form. Also, appointments are not made during menstruation and in the first period of pregnancy. Caution is advised when using the drug for nursing women.

Candid instructions for use

The drug is in the form of a cream

The cream is applied in a thin, even layer to the affected skin surface, previously cleaned with soap and dried. Rub in with light movements. Apply two or three times a day. The duration of therapy is determined by the doctor.

Dermatomycoses are treated for at least a month, but for pityriasis versicolor a week's use is enough (in severe cases it will take three weeks). Those who suffer from foot fungus should continue to apply the cream for at least two weeks after the symptoms disappear.

Candide solution

This type of drug is prescribed to treat large areas of lesions on the skin or head under the hair. Strict adherence to the instructions that come with the drug helps the treatment.

The oral cavity is treated with a cotton swab several times a day. It is advisable to continue treatment until symptoms disappear completely.

Powder

It is used evenly applied to the areas of the skin affected by the disease several times a day. The success of treatment depends largely on the regularity of application of the drug. Often the powder should also be used after the visible signs of the disease have disappeared. The duration of therapy is determined by the doctor. As a rule, this is from one to four weeks for various diagnoses.

Vaginal tablets

The drug is administered in a supine position, asking the woman to bend her knees. Administration is carried out before bedtime.

To sanitize the birth canal, one 500 milligram tablet of medication is used.

Candida during pregnancy

During pregnancy, Candide is not used often and according to strict indications. However, no information has been received about harm to the mother and her unborn baby when treated with Candida. However, only a doctor can authorize the use of Candida.

Candide for children

For children, Candide is used in the form of a solution. They treat stomatitis, strictly following the instructions and recommendations of the doctor. Treatment of fungal infections and thrush in newborns is also indicated for children.

Side effects

The use of Candida is fraught with side effects, which should be taken into account when prescribing it:

  • Tingling, burning, and skin rashes accompanied by itching were observed at the sites where the cream was applied;
  • In addition to skin irritation, swelling or blisters may develop. Typically, the skin becomes rough and irritated.

If such signs of side effects occur, Candide cream should be discontinued immediately.

Also, local irritation may occur when using vaginal tablets. However, this side effect occurs infrequently and disappears on its own with further treatment. The negative effects are expressed as follows:

  • in the form of itching accompanied by burning;
  • pain during sexual intercourse and a burning sensation by a man;
  • vaginal discharge accompanied by swelling of the vaginal mucosa;
  • urination may become more frequent with the subsequent development of intercurrent cystitis;
  • headache.

Overdose

An overdose of cream is almost impossible.

In case of accidental use of the drug orally, the patient should rinse the stomach and prescribe enterosorbents. Symptoms of this type of overdose will be the development of nausea, vomiting, and allergies. There were cases when drowsiness and hallucinations were recorded.

The development of gastralgia, pollakiuria, and anorexia may also be a consequence of the oral use of the drug, which is intended for external or vaginal use.

Symptomatic therapy is often required to eliminate unpleasant symptoms.

Drug interactions

A drug containing clotrimazole reduces its effectiveness when combined with Nystatin, Natamycin and Amphotericin B.

Apart from these drugs, there are no other examples of such incompatibility with clotrimazole.

Additional instructions

The product is not applied to the eye area.

It is necessary to monitor liver function in those patients who suffer from liver diseases.

If hypersensitivity to the drug occurs, it should be discontinued immediately.

If, after completing a month-long course of treatment, the patient does not receive the expected effect, then the treatment was chosen incorrectly. You should visit a doctor to review the course of treatment.

The medicine does not pose a danger to drivers and other technical workers.

The product is not suitable for treating skin with a violation of its integrity.

To prevent relapses when treating vaginal superinfections, it is necessary to treat both partners.

If the vagina and labia are affected, it is advisable to treat using a combination of tablets for insertion into the vagina and a cream for external treatment.

Candide analogues

An effect similar to Candida has been observed in a number of drugs. We are talking about medications: Antifungol, Candibene, Imidil cream, Clotrimazole, Imidil, Candida B6, Candizol, Canesten and Amyclone.

Candid price

According to the latest information from pharmacies, the cost of the drug relative to its dosage forms is distributed as follows:

  • Cream – 251 rubles;
  • solution – 372 rubles;
  • powder – 375 rubles;
  • tablets/suppositories – 82 rubles per piece.

Content

In dermatology, gynecology and other areas, doctors use the drug Candide. It is highly effective, quickly achieves results, and contains clotrimazole. Different forms of the drug are used for external and intravaginal use. Read the instructions for use of Candida and consult your doctor before starting treatment.

Candide drug

Doctors often prescribe the drug Candide - the instructions for its use contain information that the medication is an antifungal agent for treating the oral cavity, genitals and skin. The active substance of the composition is clotrimazole, which destroys the cells of bacteria and fungal pathogens, preventing them from multiplying, thereby leading to their death.

Composition and release form

Five forms of Candida are available, differing in purpose and composition. Detailed composition:

Description

Clotrimazole mg concentration

Package

Colorless transparent viscous liquid

Glycerol, propylene glycol

Dropper bottles 15 ml

Light yellow powder with a characteristic odor

Fragrance, talc, corn starch, colloidal silica

Bottles of 30 g

Vaginal gel

Homogeneous white color

Water, cetyl alcohol, chlorocresol, cetyl alcohol, sodium hydroxide, propylene glycol, carbopol, glycerol, cetomacrogol emulsion wax, benzyl alcohol

Aluminum tubes 30 g with applicator

White uniform

Water, propylene glycol, sodium hydrogen phosphate, white petrolatum, sodium dihydrogen phosphate dihydrate, liquid paraffin, butylated hydroxytoluene, cetomacrogol emulsion wax, propyl and methyl parahydroxybenzoate, benzyl alcohol

Aluminum tubes 20 g

Vaginal tablets

Oval white, truncated, biconvex, without shell

100 or 500 per 1 piece.

Talc, adipic acid, propyl and methyl parahydroxybenzoate, corn starch, povidone, colloidal silicon dioxide, sodium carboxymethyl starch, lactose monohydrate, sodium bicarbonate, magnesium stearate

Packs of 1 or 6 pcs., with applicator

Pharmacodynamics and pharmacokinetics

The entire line of drugs refers to antifungal agents with a wide spectrum of action for topical use. The active substance of the composition is clotrimazole, an imidazole derivative. Its antimycotic effect is associated with disruption of the synthesis of ergosterol, which is part of the cell membrane of the fungus. The component causes a change in tissue structure and leads to lysis (dissolution) of the fungal cell. In low concentrations it acts as a fungistatic, in high concentrations it acts as a fungicide.

At fungicidal concentrations, the drug interacts with mitochondrial enzymes working as peroxidase, which increases the concentration of hydrogen peroxide to a toxic level. Yeast-like fungi Candida, dermatophytes, Rhodotorula, Torulopsis glabrata, molds, Pityriasis versicolor (lichen versicolor) and erythrasma are sensitive to the active substance. The drug destroys gram-positive microorganisms, staphylococci, streptococci, gram-negative Bacteroides, Gardnerella vaginalis, Trichomonas vaginalis.

When applied topically, the absorption of clotrimazole is negligible, so the systemic effect is practically undetectable. When applied externally, the concentration of the active substance in the epidermis is higher than in the subcutaneous tissue and dermis. With intravaginal administration of gel or tablets, the absorption of clotrimazole is up to 10% of the dose, the concentration remains for up to 72 hours. In the liver, the substance is metabolized to inactive metabolites.

Indications for use

According to the instructions for use, indications for use are different factors. The annotation states:

  • candidal stomatitis of the oral cavity;
  • fungal skin infections;
  • erosion between the fingers caused by fungi;
  • mycoses complicated by secondary infection;
  • pityriasis versicolor;
  • erythrasma;
  • candidal vulvovaginitis, paronychia, balanitis, thrush;
  • trichomoniasis;
  • genital superinfections;
  • dermatophytosis of the scalp, face, body, legs;
  • onychomycosis (nail fungus);
  • candidiasis of the skin, anorectal area, external genitalia;
  • fungal diaper dermatitis;
  • dermatomycosis;
  • sanitation before childbirth of the birth canal.

Directions for use and dosage

Each drug in the Candide line has its own instructions for use. So, cream (erroneously called ointment) and powder are used for external application to the skin. Gel and tablets (vaginal suppositories) are administered intravaginally, drops of the solution are used to treat the oral cavity. Depending on the severity of the disease, the course and dosage regimen will differ.

Cream Candide

According to the instructions, Candida cream or ointment is applied to previously washed and dry affected areas of the skin up to 2-3 times a day. The product is lightly rubbed in and left until absorbed. Treatment of candidiasis continues for 2-4 weeks after the disappearance of clinical manifestations of the disease to ensure mycological cure and prevent recurrence of infection.

Powder

Candide powder, according to the instructions, is for external use. It is applied to the affected areas of the skin 3-4 times a day. According to reviews, improvement occurs on days 3-5, but successful treatment requires systematic use of the drug. The average duration of antifungal therapy is a month, for pityriasis versicolor - 1-3 weeks, for erythrasma - 2-4 weeks. If interdigital fungal erosions of the feet are treated, then the duration of use of the powder continues for another two weeks from the moment the symptoms are relieved.

Gel

Candide gel is intended for intravaginal use only for the treatment of thrush. According to the instructions, take a full applicator with gel (approximately 5 g) and insert it into the vagina. It is advisable to administer the drug while lying on your back with your knees slightly bent. Treatment continues every evening for six days. The repetition of the course is determined by the doctor.

Solution

The instructions suggest using Candide solution for the oral cavity in an amount of 10-20 drops (0.5-1 ml of the drug). The product is applied to the affected areas of the skin 3-4 times a day using a cotton swab. On days 3-5, patients note an improvement in their condition, but treatment should still be continued until the clinical manifestations of the disease are completely eliminated.

Candles

Candida tablets are mistakenly called suppositories. The drug is used intravaginally, injected as deeply as possible while lying on your back with slightly bent legs. Every evening you need to use one tablet for six days. To sanitize the birth canal before childbirth, one piece is prescribed. To facilitate the administration of the drug, an applicator is used. Instructions for its use (also suitable for using gel):

  • extend the piston all the way;
  • place the tablet inside;
  • carefully insert the applicator deep into the vagina;
  • slowly press the piston all the way;
  • remove the applicator;
  • Remove the piston completely, wash with warm water and soap and wipe dry.

special instructions

If Candide is used, the instructions for use involve studying the special instructions. Some of the excerpts indicate that:

  • the solution is used only as a treatment for the oral cavity;
  • intravaginal forms cannot be used during menstruation;
  • to prevent reinfection, it is advisable for the sexual partner to also undergo treatment;
  • the drugs are not used in ophthalmology;
  • for trichomoniasis, for successful treatment, therapy is combined with taking systemic medications, for example, Metronidazole;
  • with simultaneous manifestation of candidiasis on the vulva of the labia and adjacent areas, it is allowed to combine intravaginal forms of the drug with cream;
  • during pregnancy, the applicator cannot be used to administer gels and tablets;
  • when treating patients with liver failure with Candida, liver functional parameters should be monitored;
  • if signs of hypersensitivity or local irritation appear on the skin and genitals, therapy is canceled;
  • if there is no effect from the drugs within a month, the diagnosis should be reconsidered;
  • Medicines do not affect concentration and the speed of psychomotor reactions, so they can be used when driving vehicles and dangerous mechanisms.

During pregnancy

During pregnancy and breastfeeding, the instructions allow the use of the medication only if the benefit to the mother exceeds the risk to the fetus or newborn. Intravaginal forms of drugs are contraindicated in the first trimester of pregnancy. According to experimental data, high doses of clotrimazole cause embryotoxic effects. It is not known whether the active substance is excreted in breast milk.

Candide for children

There is no experience in using this line of drugs in children, so before prescribing it is worth considering the possible risk to the body. It is known that long-term use of clotrimazole in a child leads to an increased risk of adrenal suppression. Be sure to get your doctor's permission before using any dosage form of the drug and do not try to prescribe it yourself.

Drug interactions

According to the instructions, simultaneous use of clotrimazole with amphotericin B and nystatin reduces the effect of the drug. Doctors allow the combination of drugs with systemic antibiotics and antimicrobial agents, plus forms for external and intravaginal use. You should consult your doctor before using any combination of medications.

Side effects

According to patient reviews, the drugs are well tolerated. Possible adverse reactions when using them are:

  • allergic reactions, redness of the mucous membranes of the vagina;
  • burning, tingling at the site of application;
  • urticaria, erythema;
  • itching, blistering;
  • swelling, irritation of the vaginal mucosa, peeling;
  • if such symptoms appear, Candida therapy is canceled.

Overdose

When applied topically, an overdose of Candida is unlikely and does not lead to situations that threaten human life and health. With long-term use of the cream in children or with an occlusive dressing in adults, the risk of suppressing the function of the adrenal cortex increases, therefore, during treatment, the vital signs of these organs should be monitored.

Contraindications

Instructions for use Candide advises using medications with caution during pregnancy, lactation, and childhood. Contraindications for intravaginal forms of the drug are the first trimester of pregnancy and using an applicator; for all others - increased sensitivity to the components of the composition and other imidazole derivatives.

Terms of sale and storage

You can buy Candide without a prescription; it is stored away from light and children at a temperature of no more than 25 degrees. The shelf life is three years from the date of issue.

Analogs

There are many analogues of Candida based on the active ingredient clotrimazole. There are also indirect drug substitutes that have a similar therapeutic effect. Analogs of the drug include medications containing clotrimazole in the following composition:

  • Clotrimazole;
  • Kanizon;
  • Kandibene;
  • Travocort;
  • Biffon;
  • Bifunal;
  • Kanespor;
  • Mycosporus;
  • Dermazol;
  • Ketozoral.

Candida price

You can purchase the drugs in the line via the Internet or pharmacy chains. Prices for the products depend on the form of release and concentration of clotrimazole. The approximate cost will be.

Candida is the trade name of clotrimazole, a popular remedy for infections of the skin and oral mucosa, as well as urogenital diseases of fungal pathogenesis. The manufacturer of the drug is the Indian pharmaceutical company Glenmark Pharmaceuticals. The instructions for use for Candide describe it as an antimycotic agent that helps against most dermatophytes, yeasts and molds, as well as some microbes and bacteria, including streptococci, staphylococci and other gram-positive pathogens.

Clotrimazole is an active substance in the composition of the drug; it is an imidazole-based drug. Indications for use of Candida are identical to clotrimazole:

  • candidal stomatitis – a fungal disease of the oral mucosa;
  • urogenital trichomoniasis - a fungal infection caused by the bacterium Trichomonas;
  • pityriasis versicolor and/or versicolor - a fungal infection of the skin on the torso and chest;
  • foot fungus (so-called athlete's foot);
  • fungal disease of fingernails and toenails;
  • vaginal candidiasis (thrush);
  • vaginitis, vulvitis (infection of the external female genital organs);
  • fungal balanitis (disease of the skin of the head of the penis and foreskin);
  • superficial mycoses of the skin;
  • sanitation of female genital organs before childbirth.

Clotrimazole exhibits fungicidal activity - it inhibits the growth and reproduction of fungi by acting on the cell membrane of microorganisms. When used externally, it is poorly absorbed into the skin and mucous membranes.

Most of the substance accumulates in the stratum corneum of the epidermis.

Candida, depending on the form of the drug, is used for external or local application/introduction - applied to the skin or mucous membranes, and also inserted into the vagina to treat fungal diseases. Upon contact with the mucous membranes of the mouth, vagina and head of the penis, up to 10% of the active substance is absorbed.

Release forms

Candide is available in various forms intended for external and topical use:

  • cream;
  • gel;
  • vaginal tablets;
  • solution;
  • powder.

All forms of the drug contain 10 mg of clotrimazole per 1 g of substance.

Instructions for use

Based on the form of the drug, it is applied to various parts of the body (skin around the nails, feet, skin folds, penis) or inserted into the vagina using an applicator or in the form of tablets.

For the oral cavity

For candidal stomatitis, a solution is used as a local drug, which is applied to the affected areas of the oral mucosa with a cotton swab 3-4 times a day. The course of therapy is up to 5 days or until the symptoms of fungal infection of the mucous membrane completely disappear.

For exposed skin

For the treatment of foot and nail fungus, cutaneous mycoses, color or pityriasis versicolor, manifested in the form of rashes, pigment spots, redness and itching in the folds of the skin, a gel/cream is taken. A small amount of the substance should be applied to the skin or mucous membranes 1-2 times a day after skin hygiene. The course of therapy is up to 3-4 weeks, plus another 14 days to consolidate the result.

For genitals

Candida can be used by both men and women to treat mycoses of the vulva, vagina, urethra and glans penis and foreskin. For infections of the vulva (external genitalia of women) and the head of the penis, a powder or gel is used, which is applied 2-3 times a day for 1-2 weeks.

For vaginal candidiasis (thrush), tablets are used that are inserted into the vagina. The treatment regimen, according to the annotation, is 500 mg once, 200 mg every day for 3 days or 100 mg for 7 days. The gel is inserted deep into the vagina in a supine position using a vaginal applicator, which is included in the package with the drug. It is better to administer the drug intravaginally before bedtime after genital hygiene.

For urethral infection, a solution is used that is injected into the urethra using a special applicator. The drug must be used daily for 6 days.

The medicine must be stored in its original packaging, closed, in a dry place protected from direct sunlight at a temperature not exceeding 25 degrees.

Contraindications

The drug is not recommended for hypersensitivity to the active substance. During pregnancy, it is allowed to apply Candide to treat infections only on open areas of the skin - feet or hands. The medicine in the form of tablets or gel is not recommended for use in the 1st trimester, since there is no data on the effect of the active substance on the developing fetus. In the 2-3 trimester, intravaginal use in the form of tablets is conditionally permitted with the recommendation of a doctor. It is not advisable to use a special applicator with a plunger for insertion.

If there is a need to use a drug based on clotrimazole to treat thrush or stomatitis during breastfeeding, it is recommended to first consult with your doctor.

The drug is not used during menstruation. When using a cream, gel or powder to treat candidal balanitis or vulvitis, it is recommended to abstain from sexual intercourse. There is evidence that clotrimazole-based ointments and gels affect latex and may reduce the effectiveness of barrier contraceptives.

When treating genital infections in men and women, it is recommended that both partners be treated with the drug to avoid re-infection.

Dosage

For local use on open areas of the body, as well as when inserted into the vagina and local use in the oral cavity, the maximum single dose is 0.5-1 ml for solution or 500-1000 mg for tablets. The drug is well tolerated by the body, adverse allergic reactions are rare.

Side effects

Side effects noted by the manufacturer for topical or topical use of Candida include:

  • when used externally - a burning sensation, itching, redness, swelling or flaking of the skin;
  • in the treatment of urogenital fungal pathologies - itching, burning, swelling of the mucous membrane of the external genitalia, discharge from the genital tract, increased urge to urinate, pain during sexual intercourse;
  • for the treatment of candidal stomatitis - redness, itching or irritation of the oral mucosa in the area of ​​application.

If the described side effects occur, it is recommended to stop using Candida and other clotrimazole-based drugs. Dermatologists advise choosing a drug based on another antimycotic component.

Price

The cost of Candida, depending on the form of release, varies in the following values:

  • vaginal tablets – 65-80 rubles;
  • solution for external use – 330-370 rubles;
  • liquid for topical use – 260-300 rubles;
  • powder – 295-335 rubles;
  • cream for external use – 230-285 rubles;
  • vaginal gel – 100-120 rubles.

Analogs

Candida has several analogues - preparations for external and local use based on clotrimazole:

  • Candide-B6 (tablets).
  • Clotrimazole (cream and ointment, tablets).
  • Kanizon (cream, gel, tablets for insertion into the vagina, powder for external use).
  • Kandizol (tablets for insertion into the vagina, cream for external use).

Clotrimazole is also included in such drugs as Canesten, Imidil, Amyclone, Faktodin, Candibene.

The drugs described above are synonyms or complete structural analogues, because have the same active ingredient. Cheap analogues of Candida that have similar pharmacological effects include drugs based on other antifungal drugs:

  • ketoconazole (trade names Livarol, Dermazol, Mycozoral);
  • miconazole (in the preparations Ginezol 7, Mikozon);
  • naftifine (Exoderil, Mizol Evalar);
  • terbinafine (Lamisil, Lamican, Fungoterbin);
  • fluconazole (Diflucan, Flocoside, Flucostat).

These and other antifungal drugs are recommended for the treatment of skin fungal diseases of the nails, feet, urogenital fungal infections, stomatitis and other focal lesions of the skin and mucous membranes. The drugs can be found in the form of external and local use (gels, creams, powders, solutions, sprays, shampoos).

Overdose

There is no evidence of overdose with clotrimazole for external or topical use. If accidentally ingested, symptoms such as nausea, vomiting, heartburn, loss of appetite, stomach pain, and liver dysfunction may occur. Treatment is symptomatic (taking sorbents, antacids, antiemetic drugs).

3D images

Compound

Description of the dosage form

Colorless, transparent, viscous liquid.

pharmachologic effect

pharmachologic effect- broad spectrum antifungal.

Pharmacodynamics

Clotrimazole is an imidazole derivative, a broad-spectrum antifungal agent.

The antimycotic effect is associated with a disruption in the synthesis of ergosterol, which is part of the cell membrane of fungi, which causes a change in its structure and properties and leads to cell lysis.

Dermatophytes, yeast-like fungi (genus Candida, Torulopsis glabrata, Rhodotorula), molds, as well as the causative agent of lichen versicolor Pityriasis versicolor and the causative agent of erythrasma.

Has an antimicrobial effect against gram-positive (staphylococci and streptococci) and gram-negative bacteria ( Bacteroides, Gardnerella vaginalis), as well as in relation to Trichomonas vaginalis.

Pharmacokinetics

When applied topically, the adsorption of clotrimazole from the mucous membranes is insignificant.

Indications for the drug Candide

Candidal stomatitis.

Contraindications

Hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

The use of the drug during pregnancy or lactation is permitted in cases where the expected benefit to the mother outweighs the risk to the fetus or infant.

Side effects

The drug is usually well tolerated. In rare cases, with hypersensitivity to the components of the drug, allergic reactions are observed - redness of the oral mucosa, burning and tingling sensation at the site of application of the drug, urticaria.

If irritation occurs, the drug must be discontinued.

Interaction

When used simultaneously with amphotericin B and nystatin, the activity of clotrimazole may decrease.

Directions for use and doses

Locally, 10-20 drops (1/2-1 ml) are applied to the affected areas of the oral cavity using a cotton swab 3-4 times a day. Improvement in the condition usually occurs on the 3-5th day of treatment, but treatment must be continued until the clinical manifestations of the disease are completely eliminated.

Overdose

Cream Candide contains active ingredient clotrimazole , as well as auxiliary components: white petrolatum, propylene glycol, emulsion cetomacrogol wax, liquid paraffin, butylated hydroxytoluene, propyl parahydroxybenzoate, methyl parahydroxybenzoate, benzyl alcohol, sodium hydrogen phosphate, sodium dihydrogen phosphate dihydrate, purified water.

Candide solution contains the active ingredient clotrimazole , as well as glycerol and propylene glycol as additional components.

Vaginal tablets contain clotrimazole as an active ingredient, as well as additional ingredients: purified talc, starch, magnesium stearate, lactose, silicon dioxide, propylparaben, methyl parahydroxybenzoate, sodium carboxymethyl starch.

Release form

The medicine has several forms of release. Currently produced are Candide gel 2%, cream for external use 1%, powder for external use 1%, solution for topical use 1%, as well as vaginal tablets (suppositories) Candide.

  • The cream is a homogeneous white substance, contained in a 20 g aluminum tube.
  • A solution for topical use, transparent, colorless, has a viscous consistency. The bottle contains 15 g of product.
  • Powder for external use (powder) is contained in a 30 g plastic bottle.

pharmachologic effect

The drug produces a local antibacterial and antifungal effect, and also has an antiprotozoal and trichomonacid effect. There is a wide range of antifungal effects.

Antimycotic effect clotrimazole (the active component of the drug is an imidazole derivative) occurs due to a disruption in the synthesis of ergosterol, which is part of the fungal cell membrane. As a consequence, the permeability of the membrane changes and subsequent cell lysis occurs.

There is an interaction of fungicidal concentrations with mitochondrial and peroxidase enzymes, and as a result, the concentration of hydrogen peroxide increases to a toxic level. As a result, the fungal cells are destroyed.

Fungistatic and fungicidal activity against dermatomycetes was noted ( Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), mold and yeast-like fungi (fungi Candida spp., Torulopsis glabrata, Pityrosporum orbiculare, kind Rhodotorula).

Clotrimazole also demonstrates activity against the causative agent of lichen versicolor.

The product is effective against gram-positive bacteria and a number of gram-negative bacteria. Provided that high concentrations are used, the product is active against Trichomonas vaginalis.

Pharmacokinetics and pharmacodynamics

Clotrimazole is poorly absorbed through the skin and mucous membranes, so when the drug is used externally, no systemic effect is observed. When applied externally, a higher concentration of clotrimazole is observed than in the subcutaneous tissue and dermis.

When administered intravaginally, the absorption of clotrimazole is equal to 3% to 10% of the dose that is administered. Within 2 to 3 days, small concentrations of the active substance are observed in and high concentrations are observed in the vaginal secretion.

Side effects

The following side effects may develop when using this drug:

  • , burning and tingling sensation where the cream was applied;
  • , blisters , peeling and irritation of the skin.

If such manifestations are noted, you need to discontinue Candida ointment.

When Candida is used intravaginally, the development of local irritation is rarely observed, which, as a rule, disappears on its own with further treatment. Also, with intravaginal use of the drug, the following negative effects may develop:

  • itching, burning;
  • vaginal discharge and swelling of the mucous membrane;
  • frequent urination and intercurrent ;
  • burning sensation in the male genitals.

Instructions for use of Candida (Method and dosage)

Cream Candide, instructions for use

The ointment is applied externally. Before applying the product, you must first clean and dry the areas of the skin that have been affected. For cleaning, use soap with a neutral pH value. The cream is applied in a thin layer and gently rubbed into the skin, doing this two to three times a day. Treatment lasts as long as the doctor prescribes. Its duration depends on the location and severity of the disease, as well as on the effectiveness of treatment.

When treating dermatomycosis, the course of use is at least 4 weeks; when treating pityriasis versicolor, the cream should be applied for 1 to 3 weeks. People who suffer from fungal diseases of the skin of the legs should apply the cream regularly for at least two weeks after the symptoms of the disease have disappeared.

How to use the gel also depends on the severity and characteristics of the disease. As a rule, the product is rubbed into the affected area 2-3 times a day. It is advisable to use the gel for another 3-4 weeks in order to completely eliminate possible relapses.

Candide solution, instructions for use

The product in the form of a solution is prescribed for large lesions of the skin, as well as for lesions of the scalp. If a patient is prescribed Candida drops, the instructions for use must be carefully followed. If the oral cavity is affected, apply 10-20 drops of the solution using a cotton swab, doing this 3-4 times a day. It is important to treat all affected areas very carefully. The product should be used until the clinical symptoms disappear.

Instructions for the powder

Candide powder is used externally; it should be applied to the affected areas of the skin 3-4 times a day. It is important to apply the product regularly. The duration of therapy depends on the severity of the disease, as well as on the location of the disease. To completely cure the disease, sometimes treatment continues after the symptoms disappear. The duration of treatment is usually 4 weeks. Patients with pityriasis versicolor are recommended to use the drug for 1-3 weeks, patients suffering from erythrasma , it is indicated to carry out treatment for 2-4 weeks.

The product in the form of vaginal tablets is administered intravaginally; this should be done in a lying position with legs bent. It is necessary to take the tablets once a day, before bedtime. To sanitize the birth canal, one tablet (500 mg of the drug) is administered.

Overdose

When using the cream in high doses, no reactions or life-threatening conditions are observed.

If the drug is taken orally, the patient may develop nausea, vomiting, gastralgia, anorexia, pollakiuria, and allergic manifestations. Development is rarely noted , . There is no specific drug; when Candida drugs are taken orally, a dose is prescribed; symptomatic therapy is also practiced.

Interaction

The effect of clotrimazole is reduced with simultaneous use of drugs Nystatin, , Natamycin , which is why Candide ointment and other forms of the drug should not be used when treating with the listed drugs.

In general, when using the cream simultaneously with other medications, the negative effects of other drugs are unknown, since the low resorption capacity of clotrimazole is noted.

Terms of sale

Sold without a doctor's prescription.

Storage conditions

All forms of Candida should be kept away from children and stored at a temperature of 2 to 25 °C.

Best before date

Candid ointment can be stored for 4 years, Candid solution can be stored for 3 years.

special instructions

Do not apply the product to the skin in the eye area.

When using the medicine, the condition of the liver of a patient who suffers from liver failure should be periodically monitored.

If signs of high sensitivity appear during use, treatment with the drug should be discontinued.

If, after using the product for 4 weeks, there is no effect from the treatment, it is necessary to confirm the diagnosis by visiting a specialist.

The use of the product does not affect the ability to drive vehicles and operate precision machinery.

You should not apply the product for external use to those areas of the skin where there are violations of integrity.

To prevent the development of urogenital reinfection, it is important to treat both sexual partners simultaneously.

If the vagina and labia are affected, Candida cream and vaginal tablets should be used simultaneously.

Analogs

Level 4 ATX code matches:

A number of drugs with similar effects are produced. These are medications , Imidil cream , Imidil , Kanesten , Candid-B6 , , etc. The price of analogues depends on the manufacturer, release form, and packaging of the drug.

Cream Candide and Candide B have a similar effect, however, Candide B, in addition to clotrimazole, also contains beclomethasone as an active ingredient.

For children

The remedy Candide in the form of a solution is used for stomatitis in children; it must be used in accordance with the instructions and on the recommendation of a doctor. The product is also used in the treatment of a number of fungal diseases, in particular it is used to treat children from . Candida for thrush in newborns and children is used strictly as prescribed by the doctor.

Candide for newborns

Candida solution for newborns is used to treat candidiasis in infants. It is necessary to carry out procedures for thrush in infants after feeding. To carry out this procedure, apply a few drops of solution (3-4 drops) to a cotton swab or swab, and then carefully lubricate those areas in the oral cavity that have been affected. This procedure should be carried out three times a day. Within 2-3 days there should be clear signs of improvement.

During pregnancy and lactation

There is no clinically established data that the use of Candide medication topically during pregnancy, as well as during breastfeeding, negatively affects the health of the woman or the unborn child. But it is important that the decision to use the drug during the second and third trimester of pregnancy, as well as during lactation, is made by a doctor.

Do not apply the product to the mammary glands during lactation.

Reviews about Candida

There are mostly positive reviews about Candide cream online. Users note that the ointment is very effective in overcoming problems associated with the development of fungal diseases. Candida solution is often used by parents to treat children, noting that the drops are easy to use and that the negative manifestations of diseases are reduced almost from the first use. Adult patients also write that with the help of a cream or gel they were able to completely cure fungal diseases and get rid of unpleasant symptoms. Thus, Candide cream is no less effective than any other suppositories or other forms of medicine.

Candida price, where to buy

The price of Candide cream 1% is from 250 rubles per package of 20 g. The ointment may cost more, depending on the place of sale. The price of Candide solution is on average 370 rubles. per pack 20 ml. How much this form of the drug costs depends on the packaging. Drops for children in a 15 ml package can be purchased at a price of 270 rubles.

Powder for external use costs an average of 340-380 rubles per 30 g package. Powder for newborns is sold without a prescription at any pharmacy. Gel Candide costs an average of 120 rubles. per pack 30 g. Price of Candida suppositories (cost of vaginal tablets) – from 80 rubles. for 1 piece

  • Online pharmacies in Russia Russia
  • Online pharmacies in Ukraine Ukraine
  • Online pharmacies in Kazakhstan Kazakhstan

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