Today, diseases of the nervous system are not uncommon. And there can be many reasons for this phenomenon. For example, the wrong way of life, bad ecology, heredity, overwork and others. "Prozerin" in ampoules, the instructions for use characterizes it as an incredibly effective remedy intended for the treatment of certain ailments of the nervous system. In this article, we will consider all the features of this medicine, and also figure out how to use it correctly.
Release form and composition
The drug "Prozerin" in ampoules, the instructions for use describe as a solution intended for the injection method of treatment. The solution itself is absolutely transparent and colorless and does not have a specific smell. The main active substance of this medication is prozerin. In this case, each milliliter of the solution will contain 0.5 mg of the active substance. In addition, the drug also contains an auxiliary component.
This includes sterile water. Each vial made of glass contains 10 ml of medicine. The preparation "Prozerin" in ampoules, the instructions for use of which are included in each factory package, can be bought both individually and in a whole box, which contains ten glass test tubes.
Pharmacokinetic properties
With the correct use of such a medicinal substance as proserin, the acetylcholinesterase enzyme will be blocked in the human body. Due to this, the following effects will be observed:
- the drug has an active effect on all the muscles of the human body;
- at the same time, there is an increased work of the salivary, sweat, sebaceous and other glands;
- the pressure inside the eye will begin to decrease, and the pupil itself will narrow;
- the work of the sphincter and intestinal walls will also increase.
Usually the drug is administered intravenously, intramuscularly or subcutaneously. Which method is right for you will be determined by your doctor. The active component of the drug is able to accumulate very quickly in blood cells and spread throughout all tissues of the human body. At the same time, the drug "Prozerin" in ampoules, the instructions for use of which are described in this article, does not affect the central nervous system, which makes the medication as safe as possible. But the processes of proserin metabolism occur in the liver, after which the decay products are almost completely excreted by the urinary system.
"Prozerin" in ampoules, instructions for use and analogues of which are described in this article, can be used to treat certain diseases of the nervous system. Let us consider in more detail in which cases doctors prescribe this medicine to their patients:
- Very often, experts recommend that their patients use Prozerin injections with a significant weakening of the muscles. In this case, the etymology of the origin of the disease does not matter.
- Also, the remedy showed itself very well during the recovery period after suffering brain injuries, a stroke, or in violation of the motor function of the muscles as a result of other diseases of the nervous system.
- The tool is able to cope with atrophy of the optic nerve, as well as with inflammatory processes in it.
- The drug perfectly improves the tone of the muscles of the bladder and intestines.
- Very often, doctors recommend using Prozerin injections during the recovery period after undergoing treatment with certain types of drugs.
"Proserin" in ampoules, instructions for use and a photo of which are presented to your attention, is very often prescribed by specialists during the rehabilitation period after suffering inflammation of the meninges.
Are there any contraindications for use?
Since this medication has a very strong effect on the body, it should be taken with extreme caution and only as directed by a doctor. The medicine can be bought at a pharmacy only if you have a prescription from a doctor. So, according to the instructions for use, it is forbidden to use the drug in such cases:
- If a person has excessive sensitivity to the active ingredient that is part of this medicine.
- It is strictly forbidden to use the medication for epilepsy, as well as for excessive motor activity of skeletal muscles.
- Treatment with this drug should be abandoned in patients suffering from diseases of the cardiovascular system. This is especially true for angina pectoris and problems with arterial vessels.
- Ulcerative chronic diseases of the digestive system, leading to the formation of serious defects on the walls of the intestines and stomach.
- The remedy should not be used for prostate adenoma, which is characterized by excessive enlargement of the prostate gland.
- Doctors forbid the use of the remedy for those patients who have serious intoxication of the body. This is especially true for small children.
Specialists try in every possible way to protect their patients from self-treatment. The use of such a serious medication can adversely affect your health, so be sure to go to the hospital.
"Prozerin" in ampoules: instructions for use, method of administration, dosage
Contraindications to the use of this drug have been described above. Now it’s worth figuring out exactly how to use it in order to provide the maximum benefit to the body. As mentioned above, injections of this drug can be administered under the skin, intramuscularly and intravenously. This can only be done by a qualified specialist in a hospital environment, while observing the list of all antiseptic and hygiene rules. The dosage is selected by the doctor individually, depending on the age of the patient, as well as on the ailments that disturb him.
With myasthenia gravis, the dosage of the drug is one ampoule per day, which must be administered both subcutaneously and intramuscularly. To achieve maximum effect, these two methods of administration must be alternated. If myasthenia gravis has become acute and is accompanied by difficulty breathing and swallowing, then the drug is administered intravenously once, after which experts recommend using the method of administration under the skin.
In the presence of a disease such as atony of the gallbladder or intestines, "Prozerin" in ampoules (instructions for use and reviews of doctors confirm this) should be used at a dosage of 0.25 to 0.5 mg, depending on how severe the disease is. In this case, both subcutaneous and intramuscular methods of administration can be used. If patients have experienced an overdose of muscle relaxants, then in this case the drug should be administered intravenously for two minutes. If necessary, the procedure must be repeated one more time.
The drug "Proserin" in ampoules, instructions for use for which is very important information that every patient should be familiar with, can also be used by children, but only in a hospital setting. So, the tool can be used even for babies who have not reached the one-year period. In this case, the dosage of the active substance should be about 0.05-0.3 mg per kilogram of body weight. For children under twelve years of age, it is recommended to increase the dosage to 0.2-05 mg. In this case, only the attending physician can determine the regimen, method of application and method of treatment. In addition, the individual characteristics of each person, as well as the severity of the disease, should be taken into account.
A few words about side effects
"Prozerin" in ampoules, the instructions for use describe it as a very serious and effective drug, so you need to approach treatment issues with all responsibility. Be prepared for the fact that during treatment with this substance, various pathological processes can occur in the body from all organs and systems. Therefore, if there are unpleasant phenomena, immediately tell your doctor about it. This may lead to further adjustments in treatment.
Most often, side effects occur from the digestive system. Many patients complained of diarrhea, nausea, bloating, vomiting, and excessive salivation. In addition, against the background of the use of the drug, deviations from the cardiovascular system often occurred. Headache, dizziness, weakness and drowsiness are not excluded. Much less often, patients complained about the development of pathologies of the urinary, supporting and respiratory systems. Also, patients often experience allergic reactions to the components included in the composition. Usually, allergies make themselves felt in the form of a rash, hives and itchy skin.
Important Notes
The drug "Proserin" in ampoules, the instructions for use and the method of administration of which must be studied in as much detail as possible, should be used with extreme caution. Each doctor must take into account special instructions and prescribe treatment correctly. If the agent is used in sufficiently large dosages, then it is necessary to combine the use of the Prozerin solution with Atropine. If the patient has recently undergone surgery on the digestive system or genitourinary organs, then the remedy can only be used under strict medical supervision. The drug can be prescribed to children of any age category. However, it is recommended to do this only in a hospital under the strict supervision of the attending physician.
It is very important to take into account drug interactions, because proserin can affect the human body in different ways, depending on the drugs used by the patient. In some cases, the remedy can also be used by pregnant women. However, this should also be done under the strict supervision of the attending physician. During the course of treatment, the patient must abandon hazardous activities associated with the operation of mechanisms, since the psychomotor reactions of the body may be slowed down.
What happens in case of an overdose?
"Proserin" in ampoules, the instructions for use and the composition of which will allow you to use it correctly, must be administered very carefully, taking into account the dosage prescribed by your doctor. If an excessively large amount of the active substance enters the patient's body, then adverse reactions such as tachycardia, problems with intestinal motility and breathing, lowering blood pressure, weakness, and unconscious muscle contractions may appear. In case of overdose, treatment with the drug is stopped. In this case, the doctor must necessarily conduct symptomatic therapy.
Are there analogues?
The drug "Prozerin" in ampoules, the instructions for use and dosage of which we now know, like any other drug, has analogues. The closest in composition, as well as the effect on the body, is the drug "Neostigmine sulfate". It is possible to replace the drug only if it is recommended by your doctor.
"Prozerin" in ampoules: instructions for use for dogs
This tool can also be used in veterinary medicine. In this case, a 0.05% solution is usually used. The drug is prescribed for birth complications, disorders of the brain after injuries, with myasthenia gravis, as well as with atony of the digestive system and bladder.
How to store?
The drug "Prozerin", like any other medicine, it is very important to store it correctly. Only in this case the effect of the treatment will be maximum. The shelf life of this product is thirty-six months from the date of manufacture. However, if you store it in the wrong conditions, this period will be significantly reduced.
Ampoules should be stored in the original carton in a dark and dry place. At the same time, place the packaging so that it is out of the reach of children. The storage temperature of this medicine should not exceed twenty-five degrees Celsius.
Medication cost
The drug "Prozerin" is an old and proven tool that has appeared on the market for a relatively long time. The average price for a package of solution is about sixty to seventy rubles. Despite such a low cost, the drug has a truly miraculous effect.
findings
The drug "Proserin" in ampoules, the instructions for use and contraindications of which determine the appropriateness of use, is a very effective, but at the same time dangerous remedy that can be purchased only on the advice of a doctor. Therefore, do not sacrifice your health and approach the treatment process with all responsibility. Start taking care of your health today, and then you will not need medicines.
Properties.
White crystalline powder, odorless, bitter taste. Hygroscopic. Easily soluble in water (1:10) and alcohol (1:5).
The solutions are sterilized at 100°C for 30 minutes. Under the influence of light, the drug acquires a pink agaric. Prozerin in the form of 0.5% solution - transparent
colorless liquid, stable at storage.
Prozerin is incompatible with iodine preparations, salts of heavy metals, alkalis, oxidizing agents, salts of sulfanilamide preparations.
Kind of animal.
livestock
Release form.
Produced in powder, tablets of 0.015 g and ampoules of 10 ml of a 0.5% solution.
Action and application.
Prozerin blocks cholinesterase, prevents the hydrolytic cleavage of acetylcholine, which, accumulating, enhances the contractile activity of the uterus, stomach, intestines, constricts the pupils, and lowers intraocular pressure. It restores the course of the acetylcholine cycle in motor nerve fibers and endings, stimulates the work of neurons, increases the tone and activity of nerves.
It acts similarly to physostigmine, weaker on carnivores and omnivores, and stronger on horses and cattle.
Stimulates the secretion of the digestive glands, increases tone and increases the contraction of the smooth muscles of the digestive tract, uterus, bladder and skeletal muscles.
Changes the resting stage of the estrous cycle. It is used for barrenness of cows, injected subcutaneously at 0.01 g in the form of a 0.5% solution three times.
A 0.05% solution of prozerin is used in animals with weakness of labor, subinvolution of the uterus, retained placenta, endometritis, ovarian hypofunction, for the prevention and treatment of postoperative atony of the gastrointestinal tract of the bladder, as a ruminator. It is used for paresis and paralysis of the motor nerves, motor disorders after brain injuries, various diseases of the nerve trunks and fibers with a decrease in their functions, myasthenia gravis, optic nerve atrophy, neuritis. It is an antagonist of curare-like drugs.
With atony of the proventriculus in ruminants, atony of the bladder is also used subcutaneously 2 times a day.
With myasthenia gravis, the drug is prescribed orally or under the skin 2 times a day for 20-30 days.
The drug is administered to animals subcutaneously according to the following scheme: to cows to stimulate labor activity 3-4 ml 3 times with an interval of 1 hour, with retention of the placenta 3-4 ml twice with an interval of 12 hours, to prevent and treat subinvolution of the uterus, acute and chronic endometritis 3-4 ml with an interval of 48 hours in combination with other methods of treatment, with the ovarian cyst - after 3 days. , with hypofunction of the ovaries 2-3 ml once in combination with FFA, which is administered subcutaneously 24 hours after the injection of prozerin at a dose of 500 ME per 100 kg of body weight, pigs with the same indications 1-2 ml.
Doses subcutaneously:
horses 0.03-0.05 g,
cattle 0.02-0.04 g,
small cattle and pigs 0.005-0.01 g,
dogs 0.0004-0.001 g
Prozerin is prescribed for overdose of antidepolarizing muscle relaxants as an antidote in the same doses.
In eye practice, a 0.5% solution is used, several drops 2-3 times a day.
In case of overdose, poor tolerance and ingestion of prozerin solution into muscle tissue possible side effects due to shortness of breath, enteritis, salivation, anxiety. In such cases, the administration of the drug is stopped. As an antidotan, atropine is prescribed subcutaneously at the rate of 0.05 mg/kg of body weight.
Side effect. From the digestive system: nausea, vomiting, diarrhea, hypersalivation, flatulence, spastic contraction and increased peristalsis.
From the side of the central nervous system and peripheral nervous system: headache, dizziness, weakness, loss of consciousness, drowsiness, miosis, visual disturbances, twitching of skeletal muscles (including the muscles of the tongue), convulsions.
From the side of the cardiovascular system: arrhythmias, brady- or tachycardia, AV blockade, junctional rhythm, non-specific ECG changes, lowering blood pressure.
From the respiratory system: shortness of breath, respiratory depression, increased secretion of bronchial glands, increased tone of the bronchi.
Allergic reactions: possible skin rash, itching, anaphylactic reactions.
Others: arthralgia, increased urination, increased sweating.
Overdose.Symptoms:
associated with overexcitation of cholinergic receptors (cholinergic crisis): bradycardia, hypersalivation, miosis, bronchospasm, nausea, increased peristalsis, diarrhea, frequent urination, twitching of the muscles of the tongue and skeletal muscles, the gradual development of general weakness, a decrease in blood pressure. Treatment: reduce the dose or stop treatment, if necessary, introduce atropine (1 ml of a 0.1% solution), metacin and other anticholinergic drugs.
Contraindications. Epilepsy, hyperkinesis, arrhythmias, bradycardia, thyrotoxicosis, peptic ulcer of the stomach and duodenum, peritonitis, mechanical obstruction of the gastrointestinal tract or urinary tract, acute infectious diseases, intoxication of the weakened, hypersensitivity to neostigmine methyl sulfate.
Prescribed with caution against the background of anticholinergics, with myasthenia gravis against the background of neomycin, streptomycin, kanamycin and other antibiotics that have an antidepolarizing effect, local and some general anesthetics, antiarrhythmics and a number of other drugs that disrupt cholinergic transmission.
Use during pregnancy and lactation.
Neostigmine methyl sulfate crosses the placental barrier and is excreted in very small amounts in breast milk.
Prozerin during pregnancy and lactation is used only according to strict indications.
drug interaction.
When myasthenia gravis is prescribed in combination with aldosterone antagonists, corticosteroids and anabolic hormones. Atropine, metacin, etc. M-anticholinergics weaken M-cholinomimetic effects (pupil constriction, bradycardia, increased gastrointestinal motility, hypersalivation, etc.). It lengthens and enhances (when administered parenterally) the effect of depolarizing muscle relaxants (ditilin, etc.), weakens or eliminates antidepolarizing ones.
store
(list A) in well-closed orange glass jars in a place protected from light at a temperature not exceeding 25 ° C.
As part of drugs in tablets contains active ingredient neostigmine methyl sulfate , as well as additional ingredients: potato starch, sucrose, calcium stearate.
Part Prozerin in the form of a solution contains the active ingredient neostigmine (0.5 mg) and water for injection as an additional component.
Release form
- Produced Prozerin tablets which are contained in packs of 20 pcs. (two blister packs each). White tablets.
- Prozerin in the form of a solution contained in ampoules of 1 ml.
pharmachologic effect
The pharmacological group of the drug is a cholinesterase inhibitor. It is a synthetic anticholinesterase drug that reversibly blocks cholinesterase. As a result of this action, acetylcholine accumulates and its effect on tissues and organs increases. As a result, neuromuscular conduction is restored.
Under the influence of the drug, the heart rate decreases, the secretion of the bronchial, salivary, sweat glands, as well as the glands of the digestive tract increases. In turn, this contributes to the manifestation of bronchorrhea, hypersalivation, and an increase in the level of acidity of gastric juice.
The active substance causes pupillary constriction, lowers , provides stimulation of the tone of the smooth muscles of the intestines and bladder, tones the skeletal muscles, provokes bronchospasm.
Prozerin is an antagonist of antidepolarizing curariform drugs. When taking large doses, the drug can provoke a violation of neuromuscular conduction, which occurs due to the accumulation of acetylcholine. It produces a direct n-cholinomimetic effect. The influence of the agent coincides with the characteristic effects of excitation of the cholinergic nerves. It does not cause central effects, in comparison with it provides more active stimulation of the muscles of the bladder, intestines, uterus. Little effect on the heart.
Pharmacokinetics and pharmacodynamics
After the introduction of neostigmine methyl sulfate parenterally, the substance undergoes hydrolysis . It also occurs in the liver, in which inactive ones are formed. It binds to proteins by 15-25%. It is excreted from the body through the kidneys, while 80% of the substance is excreted within 24 hours, while approximately 50% is excreted as metabolites. It penetrates poorly through the BBB.
Indications for Prozerin's use
There are the following indications for the use of Prozerin:
- movement disorders after brain injury;
- recovery after , meningitis, ;
- open-angle ;
- with intestinal atony, atony of the digestive tract as a whole;
- atony of the bladder;
- neuritis, ;
- weak labor activity (in rare cases);
- in order to eliminate disorders of neuromuscular transmission with non-depolarizing muscle relaxants.
The use of funds for children is practiced in similar cases.
Contraindications
The medicine can not be used for such diseases and conditions:
- hyperkinesis;
- arrhythmia, bradycardia;
- vagotomy ;
- ischemic heart disease (including angina pectoris);
- expressed;
- stomach and duodenal ulcer;
- thyrotoxicosis;
- peritonitis;
- mechanical obstruction of the urinary tract or digestive tract;
- prostate hyperplasia;
- acute infectious diseases;
- in children weakened by diseases;
- high sensitivity to neostigmine methyl sulfate .
Side effects
Injections and taking Prozerin tablets can cause the following side reactions:
- digestion: , hypersalivation, vomiting, , nausea, increased peristalsis;
- central and peripheral NS: and, blurred vision, weakness, miosis, , convulsions, impaired consciousness, dysarthria, skeletal muscle twitching;
- heart and blood vessels: , bradycardia, arrhythmia, AV blockade, junctional rhythm, non-specific ECG changes, decrease;
- allergic manifestations: rash on the skin, flushing of the face, anaphylactic manifestations;
- breath: respiratory depression, increased bronchial tone, increased secretion of bronchial glands, ;
- other manifestations: increased urination, increased sweating, arthralgia.
Application instruction of Prozerin (Way and dosage)
Injections with Prozerin, instructions for use
In order to use the drug to stop the effect of muscle relaxants, it is initially administered intravenously atropine sulfate (0.5-0.7 mg), then wait until the pulse quickens and after about 2 minutes, 1.5 mg of Prozerin is administered intravenously. If the effect is insufficient, a similar dose is administered repeatedly. In total, the introduction of 5-6 mg of the drug for about 30 minutes is allowed.
In ophthalmology, it is practiced to introduce 1-2 drops into the conjunctival sac from 1 to 4 times a day.
Oral administration is carried out at the rate of 10-15 mg 2-3 times a day for adults and 1 mg per day for 1 year of life for children under 10 years of age. The highest allowable dose for adults is 50 mg per day, for children - 10 mg per day.
Overdose
With an overdose of the drug, symptoms occur that are associated with the process of overexcitation of cholinergic receptors (the so-called cholinergic crisis). Hypersalivation, miosis, bradycardia, nausea, bronchospasm, frequent urination, general weakness, twitching of the muscles of the skeletal muscles and tongue, lowering may develop.
In this case, you need to reduce the dose of the drug or stop taking it completely. If there is such a need, the patient is administered, as well as other drugs with anticholinergic action.
Interaction
It should be borne in mind that neostigmine methyl sulfate is an antagonist of non-depolarizing muscle relaxants, therefore, when taken simultaneously, it activates the effect of depolarizing muscle relaxants.
If applied at the same time ganglioblockers, m-cholinergic blockers, Novocainamide, Quinidine, local action, tricyclic antidepressants , drugs with antiepileptic and antiparkinsonian action, the effect of neostigmine methyl sulfate is reduced.
The effect of neostigmine methyl sulfate is potentiated when taken .
When taking neostigmine methyl sulfate and beta blockers may intensify bradycardia .
Terms of sale
You can buy Prozerin by prescription, the doctor writes out a prescription in Latin.
Storage conditions
Store in a dark and dry place, at t not more than 25 degrees.
Shelf life
Prozerin in ampoules is stored for 1.5 years, in tablets - 5 years.
special instructions
Injections and pills are used with caution in people with Addison's disease.
When administered parenterally in large doses, Atropine must be administered simultaneously or preliminarily.
If during treatment a myasthenic crisis develops (due to an insufficient dose) or a cholinergic crisis (due to an overdose), a thorough differential diagnosis should be carried out due to the similarity of signs.
Prozerin's analogs
Coincidence in the ATX code of the 4th level:An analogue of this medicine is a remedy Neostigmine methyl sulfate . Analogues according to the mechanism of action - drugs Armin , Amiridin , Deoxypeganine hydrochloride , Oksazil .
children
For the treatment of children, it is recommended to use Prozerin in the form of granules, which are previously dissolved in water. Children under 10 years of age are shown taking 1 mg of medication per day for each year of life. Electrophoresis with Prozerin is also practiced for children under the supervision of a doctor.
During pregnancy and lactation
The active substance penetrates the placental barrier, passes in small amounts into breast milk. Therefore, it is possible to use the remedy during the period and at the time only if there are strict indications.
"Prozerin" solution for injection 0.05%, 5 ml - drug acetylcholine cycle in the motor nerve fibers and endings, excites the work of neurons, increases the tone and activity of nerves in cattle and small cattle, pigs, dogs.
Description and composition:
Packing: 5 ampoules of 1 ml of 0.05% solution.
Pharmacological properties:
Prozerin blocks cholinesterase, prevents the hydrolytic cleavage of acetylcholine, which, accumulating, enhances the contractile activity of the uterus, stomach, intestines, constricts the pupils, and lowers intraocular pressure. Changes the resting stage of the estrous cycle.
Indications:
- When cows are lethargic: 0.01 g is injected subcutaneously in the form of a 0.5% solution, three times.
- With weakness of labor, subinvolution of the uterus, retained placenta, endometritis, ovarian hypofunction, for the prevention and treatment of postoperative atony of the gastrointestinal tract and bladder; as a ruminator. It is used for paresis and paralysis of the motor nerves, for motor disorders after brain injuries, various diseases of the nerve trunks and fibers with a decrease in their functions, for myasthenia gravis, atrophy of the optic nerve, and neuritis. It is an antagonist of curare-like drugs. With atony of the proventriculus in ruminants, atony of the bladder: subcutaneously 2 times a day.
- With myasthenia gravis: the drug is administered orally or under the skin 2 times a day for 20-30 days.
The drug is administered subcutaneously:
- cows to stimulate labor activity: 3-4 ml 3 times with an interval of 1 hour. When retaining the placenta 3-4 ml 2 times with an interval of 12 hours. For the prevention and treatment of subinvolution of the uterus, acute and chronic endometritis 3-4 ml with an interval of 48 hours. In combination with other methods of treatment: with an ovarian cyst - after 3 days, with ovarian hypofunction - 2-3 ml once in combination with FFA, which is administered subcutaneously 24 hours after the injection of prozerin at a dose of 500 IU per 100 kg of weight.
- pigs with the same indications 1-2 ml.
Doses for animals:
Prozerin is prescribed for overdose of antidepolarizing muscle relaxants as an antidote in the same doses.
In eye practice, a 0.5% solution is used, several drops 2-3 times a day.
Contraindications: epilepsy, hyperkinesis, arrhythmias, bradycardia, thyrotoxicosis, peptic ulcer of the stomach and duodenum, peritonitis, mechanical obstruction of the gastrointestinal tract or urinary tract, acute infectious diseases, intoxication in the weakened, hypersensitivity to neostigmine methyl sulfate.
Description: clear colorless liquid.
Packing: 5 ampoules of 1 ml of 0.05% solution.
Terms and conditions of storage: in a dry, dark place, at a temperature not exceeding 25 ° C. Shelf life - 2 years.
Properties.
White crystalline powder, odorless, bitter taste. Hygroscopic. Easily soluble in water (1:10) and alcohol (1:5).
The solutions are sterilized at 100°C for 30 minutes. Under the influence of light, the drug acquires a pink agaric. Prozerin in the form of 0.5% solution - transparent
colorless liquid, stable at storage.
Prozerin is incompatible with iodine preparations, salts of heavy metals, alkalis, oxidizing agents, salts of sulfanilamide preparations.
Kind of animal.
livestock
Release form.
Produced in powder, tablets of 0.015 g and ampoules of 10 ml of a 0.5% solution.
Action and application.
Prozerin blocks cholinesterase, prevents the hydrolytic cleavage of acetylcholine, which, accumulating, enhances the contractile activity of the uterus, stomach, intestines, constricts the pupils, and lowers intraocular pressure. It restores the course of the acetylcholine cycle in motor nerve fibers and endings, stimulates the work of neurons, increases the tone and activity of nerves.
It acts similarly to physostigmine, weaker on carnivores and omnivores, and stronger on horses and cattle.
Stimulates the secretion of the digestive glands, increases tone and increases the contraction of the smooth muscles of the digestive tract, uterus, bladder and skeletal muscles.
Changes the resting stage of the estrous cycle. It is used for barrenness of cows, injected subcutaneously at 0.01 g in the form of a 0.5% solution three times.
A 0.05% solution of prozerin is used in animals with weakness of labor, subinvolution of the uterus, retained placenta, endometritis, ovarian hypofunction, for the prevention and treatment of postoperative atony of the gastrointestinal tract of the bladder, as a ruminator. It is used for paresis and paralysis of the motor nerves, motor disorders after brain injuries, various diseases of the nerve trunks and fibers with a decrease in their functions, myasthenia gravis, optic nerve atrophy, neuritis. It is an antagonist of curare-like drugs.
With atony of the proventriculus in ruminants, atony of the bladder is also used subcutaneously 2 times a day.
With myasthenia gravis, the drug is prescribed orally or under the skin 2 times a day for 20-30 days.
The drug is administered to animals subcutaneously according to the following scheme: to cows to stimulate labor activity 3-4 ml 3 times with an interval of 1 hour, with retention of the placenta 3-4 ml twice with an interval of 12 hours, to prevent and treat subinvolution of the uterus, acute and chronic endometritis 3-4 ml with an interval of 48 hours in combination with other methods of treatment, with the ovarian cyst - after 3 days. , with hypofunction of the ovaries 2-3 ml once in combination with FFA, which is administered subcutaneously 24 hours after the injection of prozerin at a dose of 500 ME per 100 kg of body weight, pigs with the same indications 1-2 ml.
Doses subcutaneously:
horses 0.03-0.05 g,
cattle 0.02-0.04 g,
small cattle and pigs 0.005-0.01 g,
dogs 0.0004-0.001 g
Prozerin is prescribed for overdose of antidepolarizing muscle relaxants as an antidote in the same doses.
In eye practice, a 0.5% solution is used, several drops 2-3 times a day.
In case of overdose, poor tolerance and ingestion of prozerin solution into muscle tissue possible side effects due to shortness of breath, enteritis, salivation, anxiety. In such cases, the administration of the drug is stopped. As an antidotan, atropine is prescribed subcutaneously at the rate of 0.05 mg/kg of body weight.
Side effect. From the digestive system: nausea, vomiting, diarrhea, hypersalivation, flatulence, spastic contraction and increased peristalsis.
From the side of the central nervous system and peripheral nervous system: headache, dizziness, weakness, loss of consciousness, drowsiness, miosis, visual disturbances, twitching of skeletal muscles (including the muscles of the tongue), convulsions.
From the side of the cardiovascular system: arrhythmias, brady- or tachycardia, AV blockade, junctional rhythm, non-specific ECG changes, lowering blood pressure.
From the respiratory system: shortness of breath, respiratory depression, increased secretion of bronchial glands, increased tone of the bronchi.
Allergic reactions: possible skin rash, itching, anaphylactic reactions.
Others: arthralgia, increased urination, increased sweating.
Overdose.Symptoms:
associated with overexcitation of cholinergic receptors (cholinergic crisis): bradycardia, hypersalivation, miosis, bronchospasm, nausea, increased peristalsis, diarrhea, frequent urination, twitching of the muscles of the tongue and skeletal muscles, the gradual development of general weakness, a decrease in blood pressure. Treatment: reduce the dose or stop treatment, if necessary, introduce atropine (1 ml of a 0.1% solution), metacin and other anticholinergic drugs.
Contraindications. Epilepsy, hyperkinesis, arrhythmias, bradycardia, thyrotoxicosis, peptic ulcer of the stomach and duodenum, peritonitis, mechanical obstruction of the gastrointestinal tract or urinary tract, acute infectious diseases, intoxication of the weakened, hypersensitivity to neostigmine methyl sulfate.
Prescribed with caution against the background of anticholinergics, with myasthenia gravis against the background of neomycin, streptomycin, kanamycin and other antibiotics that have an antidepolarizing effect, local and some general anesthetics, antiarrhythmics and a number of other drugs that disrupt cholinergic transmission.
Use during pregnancy and lactation.
Neostigmine methyl sulfate crosses the placental barrier and is excreted in very small amounts in breast milk.
Prozerin during pregnancy and lactation is used only according to strict indications.
drug interaction.
When myasthenia gravis is prescribed in combination with aldosterone antagonists, corticosteroids and anabolic hormones. Atropine, metacin, etc. M-anticholinergics weaken M-cholinomimetic effects (pupil constriction, bradycardia, increased gastrointestinal motility, hypersalivation, etc.). It lengthens and enhances (when administered parenterally) the effect of depolarizing muscle relaxants (ditilin, etc.), weakens or eliminates antidepolarizing ones.
store
(list A) in well-closed orange glass jars in a place protected from light at a temperature not exceeding 25 ° C.
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