Phezam the therapeutic effect as quickly comes. Phezam. What are Phezam capsules prescribed for?

For what diseases is Phezam effective and why is it prescribed - an exhaustive answer to these questions will help to avoid mistakes in treatment and achieve positive dynamics of recovery. It is worthwhile to study in more detail the direction and action of its components, as well as the effect that it provides.

Phezam: indications for use

Nootropic medicine that has a stimulating effect on blood circulation and oxygen supply to the human brain. It is prescribed for the following diseases:

disorders of blood circulation in the brain (ischemic and hemorrhagic strokes, the rehabilitation period after them, atherosclerosis)
comatose and subcomatous states due to head injuries, brain intoxication
ailments of the central nervous system (including in children) with symptoms of memory loss, attention, mood swings
dementia
encephalopathy
deterioration in visual function (with complex therapy)
vestibular disorders (labyrinthopathy, Meniere's syndrome)
migraines, kinetosis
aphasia due to vascular pathology

In addition, the medication is used in the complex treatment of high blood pressure, asthenia of psychogenic etiology and therapy of children's mental retardation. For successful treatment, you need to have a full range of information about pheses - what helps, in what doses it is used, etc.

Phezam: analogues

The main substances in its composition are piracetam (400 mg), cinnarizine (25 mg). The first has an effect on metabolism, glucose uptake and helps to protect brain cells from toxin attacks. Strengthens the brain's ability to analyze, synthesize and make non-standard decisions.

The second - provides a calming function of the drug, improves the general tone of the vessels responsible for supplying the brain with blood flow. In addition, by expanding blood vessels, it does not negatively affect pressure (intracranial or arterial).

Similar drugs have a similar effect to Phezam: acefen, cavinton, vinpotropil, vincetin, glycine, hopantam, demanol solution, idebenone, carnicetin, minisem, neuromen, nooclerin, pantocalcin, piracetam, telektol, phenotropil, and some others. Functional synonyms: piracesin, nokam, lobster (tablets).

Often, in the presence of symptoms of ischemic disease, endotoxicosis, the consequences of head injuries, doctors include Cytoflavin, Mexidol in the treatment therapy. It is noticed that their use contributes to the onset of improvements in a shorter time. The consequences of injuries are often hematomas on the face. (We wrote earlier about).

Dosages and methods of administration

The medication is a white gelatin capsule. It is recommended to drink them with a significant amount of water. 1-3 pcs are accepted. three times a day (for adults). Pediatric dosage 1-2 pcs. twice a day.

The instructions for use do not contain information on exactly when to take Phezam: before or after meals. Usually doctors advise to use it after a full meal or a light snack. This will ensure the correct assimilation of the components and the absence of negative reactions of the digestive tract, if there are deviations in its work.

A standard therapeutic course lasts up to 3 months. You can repeat the treatment 2-3 times a year. When prescribing to children (from 5 years old), strict medical supervision is required. According to statistics, it is more often prescribed to the elderly in order to improve the functions of brain activity and memory.

Piracetam or Fezam: which is better

Piracetam is an analogue of Phezam. Despite the easy tolerance, in some cases, doctors avoid prescribing it. So, often the action in its pure form causes nervous tension and increases insomnia in persons prone to nervous disorders. Do not apply if you have epilepsy.

Sometimes one doctor prescribes piracetam for a patient and another for cinnarizine. What can replace them in such a situation? It was Phezam. The influence of the two components will be more balanced and gentle for the body.

Phezam: side effects

Most of the unpleasant side effects with this medication are temporary. It is enough to suspend its use, and negative manifestations disappear on their own, without requiring additional treatment measures. These include:

nausea, rarely vomiting or diarrhea, dry mouth, increased salivation
drowsiness, dizziness, depression, twitching of the limbs, insomnia; less often there are hallucinations, disruptions in the coordination of movements
rashes (- read here), pruritus, photosensitivity, dermatitis
exacerbation of sexual desire, tremors of the limbs, excessive muscle tone
excess weight formation

Sometimes there is an overdose, the symptoms of which, when pain in the abdomen appear, are eliminated by washing the stomach.

Compatibility

It is necessary to take into account some of the features of the interaction of Phezam with other drugs. So, when combining vasodilators with it, the main components of the latter enhance the effect on the body. In addition, it improves the effects of antidepressants and antipsychotics. CNS-depressing pills may cause excessive sedation.

It is not recommended to consume alcoholic beverages during the course. In the annotation, the manufacturer indicates that fezam and alcohol are not compatible. It is advisable for athletes to discontinue the drug before passing certain tests. The gelatinous membrane can affect the level of radioactive iodine in the blood, and the components of cinnarizine will provoke traces of doping.

Contraindications and caution

It is not advisable to prescribe to pregnant women and mothers during the feeding period. Observance of caution is required in cases with patients with renal failure, abnormalities in the liver. Control of the rate of renal enzymes is important.

The effect of drowsiness (in the first days of therapy) is dangerous for people whose work is associated with driving cars or complex mechanisms. The doctor is obliged to choose the correct dosage and the duration of the course of treatment.

Phezam: reviews of patients

The majority of patients (60%) note a positive trend during treatment with this remedy. Their memory and general condition improve, attention is optimized, and mental performance increases. In addition, many notice a positive effect on the emotional background, mood, as well as calmness in emergency situations or tense moments, the absence of anxiety.

A negative attitude towards the drug is caused in people who could not overcome the barrier of side effects (drowsiness) and those who expected the onset of a too quick result. Negative reviews are promoted by cases in which the patient's condition has not changed significantly.

To achieve the best performance, complex therapy is needed. Especially if pathologies of the functions of other organs and systems are found. Real recovery is impossible, for example, by ignoring abnormalities in the genital area. (What is - written in the previous article). An individual approach, complete examination and holistic treatment will ensure a quality result.

Phezam is a two-component drug belonging to the group of nootropics. Has a vasodilating and antihypoxic effect. The main purpose is to improve blood circulation in the brain, improve metabolism.

The effectiveness of Phezam has been proven in the treatment of brain diseases, migraines and asthenic conditions. Currently, it is produced by a Bulgarian manufacturer in a single dosage form - Fezam capsules for oral administration.

The main therapeutic properties of the drug:

- Activates metabolic processes in the brain;
- Increases the resistance of neurons to hypoxia (oxygen starvation);
- Accelerates the speed of conduction of electrical impulses of nerve cells;
- Improves the ability to learn and assimilate new information in large volumes;
- Supports brain function in the elderly, improves cognitive abilities;
- Stimulates the processes of blood circulation in the body;
- Promotes the formation of new neural circuits and connections, involving new areas of the brain.

Phezam, photo of capsules

Phezam is a combined preparation, each capsule contains the following active ingredients:

Piracetam - 400 mg;
Cinnarizine - 25 mg.

Piracetam refers to nootropic drugs that are aimed at activating metabolic processes in the brain, increasing metabolism, reducing the risk of hypoxia, and improving the functioning of the central nervous system.

Cinnarizine - blocks the flow of calcium ions into the plasma, lowers the tone of smooth muscles, without lowering the patient's blood pressure. Cinnarizine has a mild antihistamine effect, this substance can reduce the excitability of the vestibular apparatus, as well as increase the tone of the sympathetic nervous system.

The active ingredients of Phezam are aimed at increasing cerebral circulation and, therefore, improving memory. Both components mutually potentiate the action aimed at reducing vascular resistance, increasing the resistance of neurocytes under conditions of ischemia.

Indications for use Fezam

cerebral atherosclerosis;
stroke;
dementia;
circulatory disorders;
aphasia due to vascular pathology;
migraine of various etiologies;
encephalopathy of various types;
Meniere's syndrome;
arterial hypertension;
visual impairment;
asthenia.

Also, an indication for Phezam can be intoxication, diseases of the central nervous system, which are accompanied by a decrease in the level of memory and attention, as well as fluctuations in the emotional background. Often, the instruction to Phezam suggests its use for adynamia, labyrinthopathy (sensation of noise, ringing, squeak in the ears, dizziness, nausea and vomiting).

There are positive reviews about Phezam as a means of combating the intellectual developmental lag in children, as well as in the prevention of seasickness, kinetosis and migraines.

The combination of the vasoactive (cinnarizine) and metabolic (piracetam) components of the Phezam preparation made it possible to use the drug in a number of clinical studies to increase the effectiveness of existing methods of treating functional and organic lesions of the optic-nervous apparatus of the eyes in children and in order to stabilize the achieved visual functions.

Instructions for use of Fezam, dosages

According to the official annotation to the medication, Phezam should be taken by adults 2 capsules 2-3 times a day, and children - 1 capsule 2 times a day. The course of treatment is 1.5-3 months.

The exact dosage of the drug and the duration of therapy should be determined only by the attending physician according to the patient's indications.

If necessary, courses of treatment with Phezam are repeated 2-3 times a year.

Application features

Ethanol, tricyclic antidepressants, antihypertensive (pressure lowering) drugs, agents that depress the central nervous system, enhance the sedative effect of the drug.

Phezam is not recommended to be taken at night - it threatens with sleep disturbance and insomnia, as well as combined with driving a car and performing work with increased attention due to possible adverse reactions from the central nervous system.

Side effects and contraindications

Side effects can appear in the form of:

various digestive disorders (dyspecia): nausea, heaviness in the abdomen, heartburn, belching, bloating;
coordination disorders, lethargy, limb tremors and decreased psychomotor reactions;
headache and dizziness;
interruptions in sleep and wakefulness;
an allergic reaction to the drug or its components: skin rash, itching, itching, dermatitis, urticaria, etc.

With a long course of treatment, in isolated cases, there may be an increase in body weight.

Overdose

Overdose cases are known, but here we are talking more about a child's body, since young patients became extremely irritable. In such situations, the active components of the medication should be removed from the body as soon as possible.

Symptoms of a medication overdose in adult patients: possible abdominal pain.

Treatment: gastric lavage should be performed and vomiting should be induced, in the future, symptomatic therapy is indicated, if necessary, hemodialysis. There is no specific antidote.

Contraindications

Phezam medicine should not be taken in the following cases:

severe renal and hepatic impairment;
psychomotor agitation during the period of drug administration;
with Huntington's chorea;
during pregnancy and lactation;
at the age of the patient up to 5 years;
with high sensitivity to the constituents of the product.

With Parkinson's disease, impaired hemostasis, severe bleeding, impaired kidney or liver function, the medicine is prescribed with caution and only after a thorough examination.

Analogues of Fezam, a list of drugs

Analogs of the drug by scope and medical indicators:

Kombitropil;
NooKam;
Omaron;
Cavinton;
Noozam;
Memozam;
Evrysam;
Piracesin;
Aminalon;
Biotropil;
Bravinton;
Vasavital;
Lucetam;
Cognifen.

Important - the instructions for the use of Fezam, the price and reviews do not apply to analogues and cannot be used as a guide for the use of drugs of similar composition or action. All therapeutic appointments must be made by a doctor. When replacing Phezam with an analogue, it is important to consult a specialist, you may need to change the course of therapy, dosages, etc. Do not self-medicate!

It should be noted that Phezam is absorbed in the body much faster than analogues of the drug. Despite the relative safety of these drugs, prior consultation with a doctor is a mandatory criterion for successful treatment.

Combined drug with a pronounced antihypoxic, nootropic and vasodilating effect. The components mutually potentiate the decrease in the resistance of the cerebral vessels and contribute to an increase in blood flow in them.

Piracetam is a nootropic drug. It activates metabolic processes in the brain by enhancing energy and protein metabolism, accelerating the utilization of glucose by cells and increasing their resistance to hypoxia. Improves interneuronal transmission in the central nervous system and regional blood flow in the ischemic zone.

Cinnarizine is a selective slow calcium channel blocker and an antagonist of histamine H 1 receptors. It was found that it inhibits the entry of calcium ions into cells and reduces their content in the plasmolemma depot. Reduces the tone of smooth muscles of arterioles, reduces their response to biogenic vasoconstrictor substances (catecholamines, angiotensin and vasopressin). It has a vasodilating effect (especially in relation to cerebral vessels, enhancing the antihypoxic effect of piracetam), without significantly affecting blood pressure. Shows moderate antihistamine activity, reduces the excitability of the vestibular apparatus, increases the tone of the sympathetic nervous system. Increases the elasticity of erythrocyte membranes, their ability to deform, reduces blood viscosity.

Pharmacokinetics

Suction

After oral administration, the drug is completely absorbed from the gastrointestinal tract.

With max piracetam in plasma is created after 2-6 hours. The bioavailability of piracetam is 100%.

The absorption of cinnarizine is slow. Cmax of cinnarizine in plasma is achieved after 1-4 hours.

Distribution

Piracetam does not bind to plasma proteins. The apparent Vd is about 0.6 l / kg. Piracetam freely penetrates the BBB. With max piracetam in the cerebrospinal fluid is achieved in 2-8 hours. Penetrates into all organs and tissues, penetrates the placental barrier. Selectively accumulates in the cerebral cortex, mainly in the frontal, parietal and occipital lobes, cerebellum and basal ganglia.

Plasma protein binding of cinnarizine is 91%.

Metabolism

Piracetam is not metabolized.

Cinnarizine is actively and completely metabolized in the liver by dealkylation with the participation of the CYP2D6 isoenzyme.

Withdrawal

T 1/2 of piracetam from blood plasma is 4-5 hours, from cerebrospinal fluid - 8.5 hours. 80-100% of piracetam is excreted by the kidneys unchanged by renal filtration. The renal clearance of piracetam in healthy volunteers is 86 ml / min.

T 1/2 of cinnarizine - 4 hours 1/3 of metabolites is excreted in the urine, 2/3 - in the feces.

Pharmacokinetics in special clinical situations

T 1/2 of piracetam is lengthened in renal failure. The pharmacokinetics of piracetam does not change in patients with hepatic impairment. Penetrates through the filter membranes of hemodialysis machines.

Release form

Hard gelatin capsules, size No. 0, cylindrical, white; the contents of the capsules are a powdery mixture from white to almost white, the presence of conglomerates is allowed, which, when pressed with a glass rod, easily turn into powder.

	1 caps.
piracetam	400 mg
cinnarizine	25 mg

Excipients: lactose monohydrate - 55 mg, colloidal silicon dioxide - 15 mg, magnesium stearate - 5 mg.

Shell composition: titanium dioxide - 2%, gelatin - 98%.

10 pieces. - blisters (3) - cardboard packs.
10 pieces. - blisters (6) - cardboard packs.

Dosage

For adults, the drug is prescribed for 1-2 caps. 3 times / day for 1-3 months, depending on the severity of the disease. The course of treatment is 2-3 times a year.

Children over 5 years of age are prescribed 1-2 caps. 1-2 times / day The course of treatment is 1.5-3 months.

Overdose

Fezam ® is well tolerated by patients; in case of an overdose, there are no serious side effects requiring discontinuation of the drug.

Symptoms: Abdominal pain is possible.

Treatment: gastric lavage should be performed, induce vomiting; carrying out symptomatic therapy; if necessary, hemodialysis. There is no specific antidote.

Interaction

With simultaneous use with the drug Fezam®, it is possible to enhance the sedative effect of drugs that depress the activity of the central nervous system, tricyclic antidepressants, and ethanol.

Fezam ® potentiates the action of nootropic and antihypertensive drugs.

With the simultaneous use of vasodilators enhance the effect of the drug.

Fezam ® improves the tolerance of antipsychotic drugs and tricyclic antidepressants.

Side effects

From the nervous system: hyperkinesia, nervousness, drowsiness, depression; in isolated cases - dizziness, headaches, ataxia, imbalance, insomnia, confusion, agitation, anxiety, hallucinations.

Allergic reactions: very rarely - skin rash, dermatitis, itching, edema, photosensitivity.

From the digestive system: in some cases - increased salivation, nausea, vomiting, diarrhea, abdominal pain.

Others: increased sexual activity.

Indications

insufficiency of cerebral circulation (atherosclerosis of the vessels of the brain, the recovery period of ischemic and hemorrhagic strokes, after traumatic brain injury, encephalopathy of various origins);
intoxication;
diseases of the central nervous system, accompanied by a decrease in intellectual and mnestic functions (impaired memory, attention, mood);
conditions after a traumatic brain injury;
psychoorganic syndrome with a predominance of symptoms of asthenia and adynamia;
asthenic syndrome of psychogenic genesis;
labyrinthopathies (dizziness, tinnitus, nausea, vomiting, nystagmus);
Meniere's syndrome;
prevention of kinetosis;
prevention of migraine;
as part of complex therapy with low learning ability in children with psychoorganic syndrome.

Contraindications

severe renal failure (CC< 20 мл/мин);
severe liver failure;
psychomotor agitation at the time of prescribing the drug;
chorea of Huntington;
pregnancy;
lactation period (breastfeeding);
children under 5 years of age;
hypersensitivity to the components of the drug.

The drug should be prescribed with caution in Parkinson's disease, impaired liver and / or kidney function, impaired hemostasis, severe bleeding.

Application features

Application during pregnancy and lactation

Despite the lack of data on the presence of a teratogenic effect of piracetam and cinnarizine, Fezam ® is contraindicated for use during pregnancy.

Piracetam is excreted in breast milk, therefore, if it is necessary to use the drug during lactation, breastfeeding should be discontinued.

Application for violations of liver function

Contraindicated in severe liver dysfunction.

Application for impaired renal function

Contraindicated in severe renal impairment.

Application in children

Contraindication: children under 5 years of age.

special instructions

Use with caution in patients with liver and / or kidney disease.

In case of mild and moderate renal failure (CC less than 60 ml / min), the therapeutic dose should be reduced or the interval between doses should be increased.

In patients with impaired liver function, it is necessary to monitor the content of liver enzymes.

Patients should avoid drinking alcohol while taking Phezam.

The drug increases the activity of thyroid hormones and can cause tremors and anxiety.

Influence on the ability to drive vehicles and control mechanisms

While taking Fezam ®, patients should be careful when driving and working with machines and equipment, since at the beginning of treatment, cinnarizine can cause drowsiness.

Phezam is a combined drug from the group of nootropics that improve cerebral circulation and, as a result, brain function. The drug is used in the treatment of cerebral circulation disorders (for example, vascular atherosclerosis, cerebrovascular insufficiency), strokes, encephalopathies of various origins (for example, against the background of hypertension, traumatic brain injuries, previous infections, etc.), dementia (dementia) of vascular origin, disorders of memory, attention and mental work, as well as labyrinthopathy, Meniere's syndrome and neurological pathology of childhood.

Composition, names and forms of release of Phezam

Currently, Phezam is produced in a single dosage form - capsules for oral administration. Often these capsules are called tablets, which is incorrect from the point of view of science, but it is quite suitable for designating a dosage form intended for oral administration. However, it should be remembered that when people say "Phezam tablets", they mean exactly the form for oral administration, that is, capsules. In addition, there is a common incorrect name for the drug "Phezama", which is often used in everyday speech. Therefore, having heard the term "Phezam", you should know that we are talking about the drug "Phezam".

Phezam contains two active ingredients:
1. Cinnarizine - 25 mg;
2. Piracetam 400 mg

This means that each capsule contains 400 mg of Piracetam and 25 mg of Cinnarizine. Due to this content of active substances, the drug is often called "Fezam 400 + 25" in the slang of medical workers. When a person sees a similar name, do not be scared, since we are talking about the same Phezam.

Phezam contains the following substances as auxiliary components:

Colloidal silicon dioxide;
Magnesium stearate.

The capsule shell is 98% gelatin and 2% titanium dioxide dye.

Phezam capsules are dense, cylindrical in shape, painted white. Inside the capsules there is a powdery mixture, painted in white or cream color. The powder inside the capsules may have small lumps, which, when pressed lightly with a dense object (for example, a spoon, glass rod, etc.), crumble and turn into powder. Fezam is available in packs of 60 capsules.

Phezam - mechanisms of action and scope of therapeutic application

The mechanism of action and therapeutic effects of Phezam are due to the active components that make up its composition. The general, resulting therapeutic and clinical property of Phezam is its ability to improve cerebral circulation and metabolism in the cells and nerve fibers of the brain. In fact, all the other effects of Phezam are due precisely to the activation of blood flow and the intensification of metabolism in brain cells.

Since Phezam is a combined drug, which includes two active components, we will consider the properties of each of them and their resulting cumulative effect.

Piracetam is a nootropic agent that improves brain activity, having a positive effect on metabolic processes. Piracetam increases the rate of consumption of glucose, which is the main nutrient for the brain, since from any other compounds the cells of the central nervous system are not able to receive the energy necessary to maintain life and function. That is, the brain cells under the influence of Piracetam begin to actively feed, producing more energy, which is quite enough to ensure the intensive work of the organ. It is thanks to this that the rate of transmission of impulses between neurons increases, memory is activated, attention is concentrated and there is a general improvement in intellectual function.

In addition, Piracetam improves blood flow to various parts of the brain that have vascular damage and moderate or weak oxygen deprivation (ischemia). Due to the improvement of microcirculation in the brain, ischemic zones suffering from oxygen deficiency disappear, and the entire volume of neurons is included in intensive work. Improving blood flow is achieved not only through direct action, but also indirectly, which consists in inhibition of platelet adhesion and, therefore, in the prevention of blood clots. Thus, Piracetam improves not only blood circulation, but also the properties of blood, making it maximally suitable for circulation through microvessels. In areas of the brain prone to ischemia, Piracetam has a protective effect, increasing the resistance of neurons to hypoxia and death.

That is, Piracetam is able not only to improve cerebral circulation, but also to enhance the integrative function of the brain (the ability to synthesize and analyze, generalize, non-standard solutions, etc.), increase the productivity of intellectual work, consolidate memory, facilitate the learning process and assimilation of new material. as well as restore and maintain brain function in the elderly.

Cinnarizine is a substance that has a pronounced effect directly on the vessels of the brain. So, cinnarizine dilates the vessels of the brain, reducing the tone of smooth muscles, as well as the severity of their reaction to biologically active substances that constrict the vessels. Cinnarizine dilates blood vessels, due to which blood flow is activated, and the supply of various parts of the brain with oxygen and nutrients is significantly improved. By improving blood circulation, the substance increases the resistance of brain tissues to a lack of oxygen. However, despite the vasodilating effect, Cinnarizine does not affect intracranial and blood pressure.

Together, Cinnarizine and Piracetam enhance the effects of each other, therefore, the severity of the resulting effect of Phezam is higher compared to the use of drugs in isolation with a time interval of admission. However, in Phezam, the sedative effect of Cinnarizine prevails, due to which a person does not feel psychomotor agitation, as when using Piracetam.

Phezam - indications for use (from which Phezam tablets)

Currently, Phezam is indicated for use for the treatment of various diseases and conditions associated with cerebrovascular accident, trauma, and disorders of integrative function. However, not all these conditions are included in the list of official indications for the use of the drug, since their effectiveness has not been scientifically proven. Therefore, we provide only a list of approved, official indications for the use of Phezam.

So, the indications for the use of Phezam are the treatment of the following diseases or conditions:

Cerebral circulation disorders of any genesis (atherosclerosis of cerebral vessels, subacute or chronic stroke, recovery period after hemorrhagic stroke, traumatic brain injury, osteochondrosis of the cervical spine, etc.);
Recovery after a traumatic brain injury;
Memory impairment;
Impaired mental function (it is difficult to clearly formulate a thought, it is impossible to find a solution to a simple problem or to think over the situation from different points of view, etc.);
Impaired concentration of attention;
Mood disorders;
Intoxication of any origin;
Asthenia of psychogenic origin (anxiety, depression, feeling of emotional discomfort, irritability, lability);
Encephalopathy of various origins (against the background of chronic hypertension, traumatic brain injury, previous infection, surgery, anesthesia, etc.);
Dementia (dementia) due to vascular pathology;
Psychoorganic syndrome with a predominance of asthenia and adynamia, provoked by infectious and inflammatory diseases of the nervous system;
Labyrinthopathy (pathology of the structures of the inner ear), manifested by tinnitus, nausea, vomiting, nystagmus, motion sickness;
Meniere's syndrome;
Aphasia (speech disorder) provoked by vascular pathology;
Prevention of kinetosis (motion sickness, "motion sickness", etc.);
Prevention of migraine;
Mild neurological pathology in children (poor learning ability, low concentration of attention, insufficient long-term memory, etc.);
In a complex method of teaching children who have a lag in intellectual development.

Phezam (tablets) - instructions for use

Phezam capsules must be taken orally, swallowing whole, without chewing, without violating the integrity of the shell and without pouring the powder into a glass of water. The capsule must be washed down with a small amount of water (at least half a glass) or any other liquid with the exception of carbonated sugary drinks, coffee and caffeine-containing energy drinks. For example, you can drink Phezam capsules with mineral water, juice, tea, compote, fruit drink and other drinks. The only condition that the Phezam drinking liquid must satisfy is a low temperature, that is, the drink should not be hot, but warm or cool.

Phezam capsules can be taken at any convenient time, regardless of the meal. However, if a person suffers from any diseases of the gastrointestinal tract, then it is better for him to take Phezam capsules 20 to 30 minutes after eating. Moreover, a light snack is quite suitable as a meal, for example, an apple, banana or other fruit, a sandwich, a piece of meat, etc.

You should try to always take Phezam capsules at the same time, for example, every day at 9-00 in the morning, or daily at 8-00 and 18-00, depending on how many times a day it is recommended to drink the drug. Moreover, if a person missed an appointment at the set time, then you should drink the capsule immediately, if the next date for taking Phezam has not approached. If, after the missed capsule, the time for taking the next one has approached, then you should drink only one, not two, without trying to compensate for the forgotten intake of the drug.

For the treatment of various diseases, adults should take Phezam 1 - 2 capsules three times a day, for one to three months. Children over 5, but under 18 years of age, also for the treatment of various diseases and conditions, should take Phezam 1 - 2 capsules, but only once or twice a day for 1.5 - 3 months. The duration of the course of therapy is determined by the severity of the disease and the rate of clinical improvement. You can not take Phezam for more than three months without a break. If necessary, courses of treatment can be repeated 2-3 times during one calendar year.

Overdose with Phezam

Overdose with Phezam during the entire period of use of the drug was recorded a very limited number of times. The drug is safe, and even exceeding the therapeutic dosage several times did not cause pronounced side effects that would force a person to stop taking Phezam. The only symptom of an overdose of Phezam in adults may be abdominal pain, which, as a rule, is normally tolerated and does not require discontinuation of the drug. An overdose of Phezam in children is manifested by insomnia, agitation, irritability, tremors, nightmares, hallucinations, or seizures.

If any symptoms of an overdose appear in adults and children, it is necessary to carry out symptomatic treatment aimed at relieving discomfort. In addition, gastric lavage is recommended. An overdose of Phezam can also be removed with hemodialysis.

Special instructions for the use of Phezam

Athletes should discontinue the drug 2 to 3 days before doping tests, as the cinnarizine contained in Phezam can give a positive test result.

In addition, the use of Phezam can give a false-positive test result for the determination of radioactive iodine, since this microelement is contained in the dye of the capsule. Phezam also activates the thyroid gland, as a result of which a person may experience tremors (tremors) in various parts of the body and anxiety.

If Piracetam causes insomnia and tension in a person, then it should be replaced with Phezam, which in such situations is the optimal drug. Also, Phezam is the drug of choice if doctors simultaneously prescribed Cinnarizine and Piracetam (this may be the appointment of different doctors).

While using Phezam, care should be taken when working with various mechanisms, including when driving, since cinnarizine at the initial stages of therapy can provoke drowsiness.

While taking Phezam, one should refrain from drinking alcohol, as this will provoke massive death of brain cells.

When using Phezam in people suffering from liver diseases, the activity of transaminases (AST, ALAT) should be monitored once a week. With an increase in the activity of transaminases by more than 1.5 times from the upper limit of the norm, Phezam should be discontinued.

If a person has kidney disease, before prescribing Phezam, creatinine clearance should be determined by Reberg's test. If the creatinine clearance is more than 60 ml / min, then Phezam can be taken at the usual dosage, monitoring this laboratory indicator every 3 to 4 days. If the creatinine clearance was initially less than 60 ml / min or fell against the background of the drug use, then the dosage of Phezam should be halved and the intervals between doses should be increased.

Application during pregnancy and lactation

In the course of experiments on animals, the absence of any negative effect of Phezam on the growth and development of the fetus was revealed. However, despite this, the drug is contraindicated for use during pregnancy. This is due to possible negative changes in the mental state of a woman, an increase in anxiety, lability of the emotional sphere and mood, which theoretically can have a bad effect on the course of pregnancy.

Since Phezam passes into milk, it is also contraindicated during breastfeeding. If a woman who is breastfeeding a baby must, for whatever reason, take Phezam, then the baby should be transferred to artificial mixtures.

Interaction with other medicinal products

Phezam, when taken simultaneously, enhances the effect of sedatives, other nootropics, antihypertensive drugs and alcoholic beverages. Moreover, Phezam enhances only the depressing effect on the central nervous system of all the listed groups of drugs.

Taking drugs that dilate blood vessels and lower pressure leads to an increase in all the effects of Phezam. Accordingly, drugs that constrict blood vessels and increase blood pressure, on the contrary, weaken the effects of Phezam.

Fezam improves the subjective tolerance of drugs from the group of antipsychotics and antidepressants.

Phezam: before or after meals - how to take

Many of the instructions for use of Phezam, which are on the package insert, do not indicate how to take the drug with respect to food intake. Usually, if it is not specifically stated how to take a drug - before, during or after a meal, this means that it can be used regardless of food, at any convenient time. This rule is also true for Phezam, which can really be taken regardless of food intake at any time convenient for a person.

However, experienced doctors or people who have used this drug more than once recommend taking it half an hour after eating. This option was chosen as the optimal one by them empirically, when they tried various methods of taking Phezam - during, before or after a meal. The empirical conclusion that it is best to take Phezam half an hour after a meal is based on the fact that it is with this option that side effects develop less often, and the drug is well tolerated.

If Phezam needs to be taken several times a day, and full meals are not possible for some reason, then you can just have a snack with something, for example, an apple, a banana, nuts, a bun, a sandwich, etc. instead of lunch, afternoon tea or dinner. A small amount of food that has entered the stomach will completely replace a full meal in terms of minimizing the discomfort from the use of Phezam. Remember that the phrase "after a meal" does not mean that you have to eat lunch, dinner, breakfast or afternoon tea that is complete from your point of view. It only means that you need to eat something before taking the medicine, for example, a piece of bread, a fruit, a sandwich, a piece of jelly or cold meat from a soup, etc.

Phezam for children

Phezam is used for therapy in children over 5 years of age. If necessary, it is allowed to use Phezam in children from one year old.

Phezam in children and adolescents normalizes sleep, eliminates nightmares, stops nighttime awakenings, reduces fatigue, increases performance, both mental and physical, and also relieves irritability, emotional instability, mood lability and excessive vulnerability. In addition, Phezam reduces the frequency of headaches in children, improves adaptation in the school or preschool team, stabilizes and maintains normal blood pressure, preventing its surges. In general, Phezam normalizes the neuropsychic status of children, especially those suffering from various disorders of the emotional-volitional sphere.

Currently, as a rule, Phezam is used to eliminate poor sleep, irritability, tearfulness, mood instability, hysteria, poor concentration and other mild disorders of the emotional-volitional sphere in children of early and school age. The drug is usually prescribed by a neurologist, not a psychiatrist, because it is not suitable for the treatment of severe mental illnesses, and it can be successfully used to eliminate mild disorders.

After a course of application, the child becomes balanced, less whiny, focused, attentive, he is not so quickly and easily upset, his mood does not change within one minute several times, he sleeps much more calmly at night, and mastering speech and other skills is more successful and faster. ... Such positive changes, combined with good tolerability of the drug, allow doctors and parents to consider Phezam an effective drug and use it to improve mental performance and development of children.

In addition, Phezam is successfully used in children for the treatment of perinatal lesions of the central nervous system, recovery from traumatic brain injuries and infectious diseases. In such situations, the drug normalizes brain function, reduces headaches, stabilizes night sleep, and also improves team adaptation and learning ability. Also, Phezam can improve the condition and contribute to the recovery of children with autism and suffering from neurological disorders of mild severity.

Phezam - side effects

Phezam is generally well tolerated and rarely causes side effects. According to international standards, all side effects are classified into several groups, depending on the frequency of their occurrence. Regarding Phezam, it was found that all side effects are recorded either sometimes or rarely. Moreover, "sometimes", according to the international classification, means that the effect develops in less than one person in a hundred, but more than 1 in 1000. And "rarely" means that a side effect develops in more than 1 person in 10,000 , but less than 1 in 1000. All side effects of Phezam are transient, that is, they disappear on their own after drug withdrawal and do not require any special treatment.

The side effects of Phezam include the following symptoms from various organs and systems:
1. From the side of the central nervous system:

Hyperkinesis (twitching of the limbs, excessive movement, etc.);

At the heart of the drug Phezam are substances such as piracetam and cinnarizine. These components have an antihypoxic effect that dilates blood vessels.

At the same time, the effect of these substances increases the efficiency of the visual and auditory functions of the body, improves the quality of blood permeability through the vessels. This medication stimulates the metabolic processes of brain cells, intensively removes excess glucose, and increases the protective functions of brain tissues.

Clinical and pharmacological group

A drug that improves blood circulation and brain metabolism.

Conditions of sale from pharmacies

Can buy with a doctor's prescription.

Price

How much does Phezam cost in pharmacies? The average price is at 320 rubles.

Composition and form of release

Fezam is available in capsule form. The manufacturer presents two packages - for 20 and 60 pieces, which do not differ in dosage. Inside the capsules there is a white powder, and the gelatinous shell itself is also white.

The capsules contain 2 main active ingredients, the content of which in one capsule is:

Cinnarizine - 25 mg.
Piracetam 400 mg

It also contains auxiliary components, which include colloidal silicon dioxide, titanium dioxide, lactose monohydrate, gelatin, magnesium stearate. Phezam capsules are packaged in a blister of 10 pieces.

Pharmacological effect

Phezam has a pronounced vasodilator, nootropic and antihypoxic effects. Its components cause a decrease in the resistance of blood vessels in the brain and increase blood flow in them.

Cinnarizine, which is part of Phezam, is a selective blocker of slow calcium channels, which inhibits the flow of calcium ions into cells and reduces their content in the plasmolemma depot. It reduces the tone of smooth muscles of arterioles and their response to vasoconstrictor substances such as dopamine, epinephrine, vasopressin, norepinephrine, angiotensin. Cinnarizine dilates the blood vessels of the brain, enhancing the effect of piracetam, but without affecting blood pressure. At the same time, it has a moderate antihistamine activity, reduces the tone of the sympathetic nervous system and the excitability of the vestibular apparatus. Increases the elasticity of erythrocyte membranes, reduces blood viscosity.

Piracetam improves metabolism in the brain by activating protein and energy metabolism, increasing the resistance of cells to hypoxia, accelerating glucose utilization; improves regional blood flow in the ischemic zone and interneuronal transmission in the central nervous system.

Indications for use

Phezam is shown for use in the following diseases and disorders of the functioning of the brain:

Meniere's disease;
circulatory disorders;
migraine of various etiologies;
encephalopathy of various types;
visual impairment;
asthenia.

Phezam's indications for use are disorders of brain activity, memory and mental ability in children.

Contraindications

A number of pathological and physiological conditions of the patient's body are distinguished, in which taking Phezam capsules is contraindicated:

Pregnancy at any stage of the course and lactation period (breastfeeding period).
The patient's age is up to 5 years.
Severe violation of the functional activity of the liver and kidneys.
Parkinsonism is a violation of the functional activity of the pyramidal system.
Individual intolerance to any of the components of the drug.

The drug is used with caution in Parkinson's disease. Before prescribing Phezam capsules, it is important to exclude the presence of contraindications.

Appointment during pregnancy and lactation

Dosage and method of administration

As indicated in the instructions for use, Fezam is recommended to take 1-2 capsules three times a day for one to three months. The duration of treatment depends on the severity of the disease. The drug is usually taken in courses - 2-3 courses annually.

Children over 5 years old are shown to take 1-2 capsules 1-2 times a day. Capsules are used for one and a half to three months. You need to take the capsules by swallowing them whole, without violating the integrity of the capsule. The pill should be washed down with half a glass of water, and it should not be hot.

Many users ask about capsules, how to take - before or after meals. In the instructions, we are talking about the fact that there is not much difference in whether to take the remedy before or after a meal. But it is optimal to drink capsules 20-30 minutes after a meal. It is advisable to drink the medicine at the same time every day.

Doctors warn that you cannot take the medicine for more than 3 months - a break is required between courses.

Adverse Reactions

Phezam can cause side effects. There have been cases when patients complained of changes in such organ systems:

Cutaneous - dermatitis, hyperhidrosis, rash, itching.
Immune - allergic reactions, hypersensitivity.
Musculoskeletal - rigidity.
Nervous - headache, vestibular disorders, insomnia, tremors, fatigue, imbalance, worsening of the course of epilepsy.
Digestive - dyspepsia, abdominal pain, nausea, cholestatic jaundice, dry mouth.

Mental disorders are also possible: depression, hyperexcitability, anxiety, hallucinations. In some patients, in response to taking the drug, there was increased sweating, weight gain, hemorrhagic disorders, and sexual arousal.

Overdose

Overdose with Phezam during the entire period of use of the drug was recorded a very limited number of times.

The drug is safe, and even exceeding the therapeutic dosage several times did not cause pronounced side effects that would force a person to stop taking Phezam. The only symptom of an overdose of Phezam in adults may be abdominal pain, which, as a rule, is normally tolerated and does not require discontinuation of the drug. An overdose of Phezam in children is manifested by insomnia, agitation, irritability, tremors, nightmares, hallucinations, or seizures.

special instructions

Before you start using the drug, read the special instructions:

Use with caution in patients with liver and / or kidney disease.
In patients with impaired liver function, it is necessary to monitor the content of liver enzymes.
Patients should avoid drinking alcohol while taking Phezam.
The drug increases the activity of thyroid hormones and can cause tremors and anxiety.
In case of mild and moderate renal failure (CC less than 60 ml / min), the therapeutic dose should be reduced or the interval between doses should be increased.

While taking the drug Phezam, patients should be careful when driving and working with machines and equipment, since at the beginning of treatment, cinnarizine can cause drowsiness.

Compatibility with other drugs

When using the drug, it is necessary to take into account the interaction with other drugs:

Phezam potentiates the action of nootropic and antihypertensive agents.
With the simultaneous use of vasodilators enhance the effect of the drug.
Phezam improves the tolerance of antipsychotic drugs and tricyclic antidepressants.
With simultaneous use with the drug Phezam, it is possible to enhance the sedative effect of drugs that depress the activity of the central nervous system, tricyclic antidepressants, and ethanol.