Levofloxacin and ofloxacin comparative ophthalmology. Ciprofloxacin or ofloxacin which is better. Release form Lomefloxacin ®

The tablet drug Lomefloxacin ® is an effective antimicrobial drug for oral administration.

The drug belongs to fluoroquinolone antibiotics. The main active ingredient is lomefloxacin.

Due to its wide spectrum of action, it is used in various fields of medicine for the treatment of bacterial infections. Helps with all types of inflammation of the urinary tract, respiratory system, osteomyelitis, skin lesions, tuberculosis. In ophthalmology, eye drops based on Lomefloxacin® are used for the treatment of inflammatory processes in the conjunctiva.

The drug belongs to the group of prescription drugs, since, along with its effectiveness, it is characterized by a rather high toxicity. It is not used to treat children, adolescents and pregnant women, has a number of restrictions on its use and requires strict medical supervision during the course of therapy. Why is it impossible to take this drug uncontrollably?

Because Lomefloxacin ® is an antibiotic belonging to the second generation of quinolones (fluoroquinolones). All medications of this group, due to the peculiarities of pharmacokinetics, are capable of replacing calcium in bone tissue, which leads to a slowdown in the growth of bone cartilage tissue in children (in this regard, the drug is contraindicated in children and pregnant women). There is also a negative effect of drugs on the nervous system, ligamentous apparatus and liver. For this reason, the use of tablets on their own, without a medical prescription, is unacceptable.

Pharmacological group

According to the generally accepted international classification, Lomefloxacin ® belongs to antibacterial agents of the fluoroquinolone class.

Composition of Lomefloxacin ®

The active ingredient of the drug with this name is the second-generation quinolone (fluorinated) antibiotic lomefloxacin of the same name. Most of the causative agents of bacterial infections have a bactericidal effect, blocking DNA gyrase and preventing further DNA replication. The following types of pathogens are susceptible to antibiotics:

• gram-positive aerobic strains of staphylococci, including staphylococcus aureus;
• gram-negative aerobes - enterobacteria, Citrobacter diversus and freundii, E. coli, Haemophilus influenzae and parainfluenzae, some varieties of Klebsiella, Moraxella catarrhalis, Proteus spp., Morganella morganii, shigella, salmonella, gonococcus and others;
• atypical microorganisms - ureaplasma, mycoplasma, chlamydia, tuberculous mycobacterium.

Lomefloxacin ® is absorbed from the digestive tract almost completely, and then it is quickly distributed to tissues, where its concentration significantly exceeds the plasma concentration. It is noted that the presence of food in the gastrointestinal tract somewhat worsens the absorption of the drug. The drug is excreted mainly by the kidneys, and practically unchanged.

Release form Lomefloxacin ®

On the basis of this antibiotic, two dosage forms are produced. The domestic pharmaceutical company "Pharmasintez" through the pharmacy chains sells tablets in an enteric film shell, where the content of the active substance is 400 mg. They are packaged in cardboard boxes of 5 pieces.

Another Russian company, JSC Sintez, produces eye drops with lomefloxacin hydrochloride in 5 ml dropper bottles under the trade name Lofox. The concentration of the antibiotic in them is 0.3%.

Lomefloxacin ® recipe in Latin

It has been prohibited to freely sell antibiotics in pharmacy chains since January last year: organizations are threatened with fines and suspension of activities for this. The ban is associated with an increase in the tolerance of infectious agents to drugs. In addition, fluoroquinolones are very dangerous to use for self-medication. To purchase the drug, you will need a prescription filled in and certified by a doctor:

Rp .: Tab. Lomefloxacini 0.4

S. t. d. No. 10

D.S. Take one tablet once a day.

Indications for use

The wide antimicrobial spectrum and the effectiveness of the drug make it possible to successfully use it in the treatment of infectious and inflammatory processes of the most diverse localization:

• (bronchitis, pneumonia, infected bronchiectasis, etc.);
• and (pyelonephritis, cystitis, prostatitis, etc.);
• , subcutaneous tissue and bone tissue;
• tuberculosis (in combination with other medicines).

In ophthalmology, lomefloxacin eye drops are prescribed in case of damage to the organs of vision by susceptible microflora (keratitis).

Contraindications

It is strictly forbidden to use the drug for pregnant women, breastfeeding, as well as children and adolescents under the age of 18 years. The prohibition is associated with the property of the antibiotic to form insoluble chemical compounds with calcium and slow down the growth of the cartilage skeleton. In addition, you should not take Lomefloxacin® in the presence of hypersensitivity to it, epilepsy, as well as inflammation of the tendons against the background of the previous intake of fluoroquinolones.

The drug is prescribed with caution in case of impaired renal and liver function, as well as with atherosclerosis and impaired cerebral circulation.

Dosages and regimens of therapy

Due to the slow elimination of the drug from the body, it is enough to take only once a day (only for tuberculosis - twice a day). In what dose and for how long - the doctor decides on the basis of the severity and nature of the disease. On average, treatment regimens are as follows:

Disease	Daily dose, mg	Treatment course, days
MEP infections are not complicated and complicated	400 for uncomplicated course, 800 for complications	from 3 to 5 for uncomplicated form and up to 10-14 with complicated diseases
Prevention of infections during transurethral interventions	400	A few hours before the operation, once
and skin infections	400	5-14
acute and chronic	800	Once to open the mold and 5 days for chronic
urogenital	400-800	up to 28
	from 400 to 800	21-56
acute, bronchopneumonia	400	10
Chronical bronchitis,	400-800	up to 14
	800	to 10

In the treatment of tuberculosis, the drug is taken at 800 mg for two to four weeks (as part of a comprehensive anti-tuberculosis therapy regimen).

Eye drops are applied daily, 2 or 3 times drop in each eye. The average course of treatment is a week.

Side effects of Lomefloxacin ®

Lomefloxacin hydrochloride (a chemical form of an antibiotic in preparations), due to toxicity, can provoke the following negative reactions:

• disorders of appetite and stool, the development of colitis;
• malaise, headaches and eye pains, sleep and consciousness disorders, tremors and convulsive syndrome;
• disorders of hematopoiesis and heart rhythm, hypotension, progression of ischemia, heart attack;
• cough flu-like symptoms, apnea, shortness of breath;
• pain in bones, joints, vasculitis;
• inflammation and rupture of tendons;
• disorders of urination, impurities in the urine, intermenstrual bleeding and vaginitis in women, in men - orchitis, epidymitis;
• inflammation and rupture of tendons;
• rash, photosensitivity, urticaria,.

Eye drops can cause a local burning sensation, and with a long course of treatment, the development of fungal superinfection.

Lomefloxacin during pregnancy and hepatitis B

Penetrating through the placenta, the antibiotic interferes with the proper development and growth of fetal bone tissue, causing other mutations. Therefore, the use of the drug Lomefloxacin® during pregnancy is unacceptable. During lactation, excreted into milk, drugs cause sensitization in infants, disturbance of the intestinal microflora, candidiasis, and slowing of skeletal growth. Therefore, breastfeeding should be discontinued during treatment.

Lomefloxacin ® and alcohol

It is unacceptable to combine such toxic antibiotics as fluoroquinolones with alcohol intake. This combination is fraught with serious complications for the liver and kidneys, moreover, against the background of alcohol intoxication, the above side effects occur more often. Therefore, the combination of Lomefloxacin ® with alcohol is not only undesirable, but even dangerous for the patient's health and life. Possible development of toxic lesions of the central nervous system, medicinal hepatitis, nephritis, etc.

Analogues of Lomefloxacin ®

On the basis of the active substance with the original name, several preparations similar in composition and action are produced:

• Lomflox ®
• Xenaquin ®
• Lomacin ®
• Lofox ®

In addition, the doctor may prescribe another antibiotic from the fluoroquinolone group as an alternative drug, if indicated.

What is the Difference Between Lomefloxacin® and Levofloxacin®

It represents the third generation of fluoroquinolone antibiotics, therefore the spectrum of its bactericidal activity is wider. It is more active in relation to gram-positive pathogens, which allows it to be used for a larger number of diseases, and optimized pharmacokinetic processes reduce the severity of side effects. In addition, there is a dosage form of Levofloxacin ® for parenteral administration.

Comparison of Ofloxacin ® and Lomefloxacin ®

Both drugs belong to the second generation of fluoroquinolones, but there is some difference between them. First, it is less toxic. Secondly, a wider spectrum of action determines the use in ENT practice for the treatment of sinusitis, otitis media and other infections. Thirdly, in addition to tablets, there is Ofloxacin in the form of ear drops and lyophilisate for intravenous administration.

Antimicrobials from the same group are continually being improved to improve antibacterial properties, safety and fight against new strains of bacteria that develop resistance over time. Levofloxacin is a fluoroquinic antibiotic third generation, developed by Japanese scientists as an improved alternative to the main representatives of the second worship: ofloxacin and ciprofloxacin. Levofloxacin is superior to ofloxacin in antibacterial activity, and ciprofloxacin is safer and more convenient dosing regimen. Let's take a closer look at these differences.

Use only as directed by a physician

What is the difference?

The main difference between levofloxacin and previous generations of fluoroquinols is its enhanced activity against gram-positive bacteria. Provides a wider range of action and indications for use in infections of the urinary tract, respiratory system, skin. Levofloxacin is more active against Streptococcus pneumoniae than ciprofloxacin. Representatives of the III generation are somewhat superior to the II and are safe, less often causing side effects from the nervous and cardiovascular systems. In practical application, levofloxacin also has a number of advantages.

• Convenient regimen of administration - 1 time per day (except for severe infections), than levofloxacin compares favorably with ciprofloxacin, which must be taken twice. For antibiotics, this is an important parameter that affects the success of treatment, as it reduces the likelihood of gaps and errors in the interval between pills.
• Better tolerance and fewer negative interactions with other medications. Less often it causes side effects, and among the most frequent (6-7% of cases): headache, nausea and mild digestive disorders that do not require treatment withdrawal.
• Excellent bioavailability both when administered intravenously and orally (orally in the form of tablets).
• Less hepatotoxicity (liver damage) than other fluoroquinols. Does not interact with alcohol in small amounts.

Among the disadvantages inherited from previous generations are rare but serious side effects:

• Peripheral nerve damage. Symptoms: pain or burning in the limbs, tingling, numbness, muscle weakness, impaired tactile sensitivity.
• Injuries (up to ruptures) of tendons, especially in the elderly over 60 years and in people taking corticosteroids. May increase the duration of fracture healing.
• Arrhythmia and prolongation of the QT interval.

Of the minor negative aspects, one can note the higher cost of branded drugs based on levofloxacin: Tavanik (Germany), Levaquin (USA). This problem is partially solved by a wide variety of domestic and Indian cheaper ones (Glevo, Levolet).

What is more efficient and better?

In the destruction of sensitive bacteria, ciprofloxacin and levofloxacin have comparable efficacy, however, the dosage regimen of levofloxacin can reduce the total course dose of the antibiotic by 25-50%, reducing the load on the liver and improving overall tolerance. This criterion is especially important when long-term treatment is required, for example, bacterial prostatitis in men.

An important clarification: the diagnosis of chronic bacterial prostatitis is often misdiagnosed. Chronic pelvic pain syndrome in men gives similar symptoms, but long-term use of fluoroquinols is meaningless and, according to the results of treatment, does not differ from placebo (). The use of antibiotics is justified only after a comprehensive diagnosis, the results of bacterial culture of the secretion of the prostate gland with the identification of the pathogen and the determination of sensitivity.

The comparative tables show the percentage of the effectiveness of therapy obtained in clinical trials (). The indicated schemes and duration of admission are standardized and averaged, in each case it is necessary to apply it as prescribed by your doctor.

Pyelonephritis and urinary tract infections (UTIs)

Both antibiotics are second-line antibiotics for UTI with similar efficacy.

Their appointment does not require a preliminary laboratory study of pathogens and determination of their sensitivity to these drugs, which makes it possible to start treatment in a timely manner.

Ofloxacin - description of the drug

Ofloxacin (Ofloxacin) - a synthetic antibacterial drug obtained as a result of the improvement of nalidixic acid, belongs to the class of fluoroquinolones, named similarly to the main active ingredient. The use of Ofloxacin for cystitis is due to the fact that it:

• It is directed to the organs of the small pelvis - the target of treatment, while it does not settle in the liver;
• Has a low level of microbial resistance;
• Has a wide spectrum of action against gram-negative and gram-positive bacteria, some types of protozoa;
• Due to the possibility of simultaneous administration with other antibacterial drugs, it is widely used as part of complex therapy for diseases of the urinary tract;
• It is widely used in the period of pre-medical care as a catalyst for the development of protective blocks in the body.

Important! Ofloxacin practically does not affect lacto- and bifidobacteria, as a result of which it occupies one of the leading positions in the sparing treatment of bacterial infectious diseases of the urinary tract.

In the case of an uncomplicated course of the disease, the drug is prescribed for a short course (from 3 to 5 days), in the case of a chronic form of cystitis, the treatment is extended up to 10 days.

The dosage is selected individually and on average ranges from 200 to 800 mg of the drug per day, calculated for several doses. A single dose, if necessary, can be 400 mg.

2 hours after administration, the drug is maximally concentrated in the blood, producing a therapeutic effect, and is excreted from the body within 24 hours. Young age (up to 18 years old), pregnancy and lactation are contraindications for taking Ofloxacin.

Levofloxacin - description of the drug

Levofloxacin (Levofloxacin) - a drug designed to fight atypical bacteria, obtained as a result of serious pharmacological developments, the ofloxacin isomer is an effective drug of the latest generation of fluoroquinolones, ideal for the systemic treatment of urinary infections in women.

The main active ingredient is levofloxacin hemihydrate, which:

• Blocks the formation of DNA of pathogenic bacteria, inhibits their reproduction;
• Prevents the penetration of pathogens into the bladder mucosa;
• Quickly relieves acute inflammation;
• Resistance develops slowly and does not interfere with other antibiotics.

The drug is bioavailable, quickly and completely absorbed by the body, due to which it penetrates well into organs, tissues and mucous membranes.

Take up to 2 times a day, swallowing the tablets completely and drinking plenty of water. The dosage is determined by the severity of the disease and ranges from 250mg to 500mg over 3-14 days.

Important! Clinical studies of the effect of the drug on women during pregnancy and lactation, as well as children, are not sufficient, therefore, its use should be determined by the degree of risk for this group of patients.

Levofloxacin or Ofloxacin. What is more effective for cystitis?

Both drugs belong to an important group of fluoroquinolones and are actively used in the therapeutic practice of treating cystitis. In the presence of identical mechanisms of action on atypical pathogens, Levofloxacin belongs to the III (new) generation antibiotics, which are characterized by a higher clinical activity and a minimal set of side effects.

When the drug is absorbed internally, Levofloxacin in cystitis behaves in relation to pathogenic microbes 2 times more active than Ofloxacin, which is an important advantage in choosing a treatment.

In case of ineffectiveness of the therapeutic course with one of the drugs, the doctor diagnoses a complicated bladder infection and sends the patient for a urological examination to identify possible pathologies and prescribes a new treatment adequate to the patient's condition.

Thickening of the bladder walls is a symptom that accompanies many diseases of the genitourinary system. The main diagnostic criterion is ultrasound. Adequate treatment will prevent the development of complications.

Levofloxacin: analogs of the active substance, features of the therapeutic effect and indications for admission

According to the instructions for use, Levofloxacin is an original broad-profile antibiotic that is active against a number of pathogens of infectious processes in the human body.

The drug Levofloxacin, analogs of which can be presented in different forms of release, can be effectively used in diseases of the ENT system. Thus, quite often this drug is prescribed to patients with otitis media, sinusitis, sinusitis, pharyngitis, etc. The active ingredient of this medication will be no less effective in relation to skin infectious lesions, as well as diseases of the urinary and reproductive systems (prostatitis, pyelonephritis, chlamydia, etc.).

According to statistics, today Levofloxacin has several medicinal analogues, which can be presented in the form of drops and tablets, and also have a cheaper price. Reviews of these drugs can be read on numerous patient forums. Moreover, more than 60% of adults are regularly exposed to infectious lesions of various body systems, so the need to use Levofloxacin is more than in demand today.

Levofloxacin is produced, analogs of which also have a wide therapeutic spectrum of action, in the form of tablets, solution for injection, and also eye drops. As for the pharmacological effect, this drug is a potent antibiotic that helps to destroy pathogenic infectious foci.

Levofloxacin, like its main substitutes, is contraindicated in pregnancy, childhood, severe kidney and liver diseases. Elderly people need to take such a drug strictly under the supervision of a doctor.

Analogs

All analogues of Levofloxacin (synonyms for therapeutic effect) are divided into two separate subgroups:

• Analogs for the active substance of the drug.
• Pharmacological group analogs.

By active substance

Levofloxacin analogs, which will be presented below, can be prescribed for the treatment of pneumonia, sinusitis, protracted bronchitis, all kinds of urological lesions, as well as pyelonephritis. It is forbidden to prescribe such drugs to children under eighteen years of age, pregnant women, as well as in case of individual intolerance to the active substance of the drug.

The most effective analogues of Levofloxacin (based on the active ingredient) are:

Levofloxacin, as well as generics, should be taken in the morning before meals. For acute infectious lesions, the permissible dosage of the drug is 250 mg (1 tablet per day). The duration of therapy is determined by the attending physician. On average, it takes five to ten days to completely suppress the infection.

As for the side effects from analogs of Levofloxacin, in comparison with the drugs of the previous generation, these drugs are much better tolerated and provoke adverse reactions in no more than 1.5% of all cases. At the same time, patients may experience nausea, abdominal pain, improved functioning of the heart, kidneys and digestive system.

According to the quinolone generation

Sparfloxacin is a striking analogue of Levofloxacin in the generation of quinolones. Also, like Levofloxacin, it belongs to the last, third generation of antibiotics. This drug is most effective against gram-negative foci of infection, in particular, staphylococci.

Sparfloxacin is prescribed with the same patient indications as Levofloxacin (analogs can be prescribed by a doctor). Thus, such an antibiotic can be used to treat chlamydia, leprosy, inflammatory diseases of the urethra and the respiratory system.

As for contraindications, apart from the standard prohibitions that are attributed to Levofloxacin, Sparfloxacin also has a prohibition in the form of bradycardia and hepatitis.

The price for such an analogue of the drug is 340 rubles per pack (6 tablets).

Tavanic or Levofloxacin: which is better, characteristics and features of the best antibiotic analogues

One of the most popular foreign analogues of Levofloxacin is the drug Tavanik, which is produced by a French manufacturer. Many patients do not know whether Tavanic or Levofloxacin is better.

With a detailed study of both of these drugs, it should be said that, unlike Levofloxacin, Tavanic has only one dosage form (solution for infusion). This is the disadvantage of this medication.

Tavanic or Levofloxacin (which is better for adults, the attending physician must decide in each case) have very similar indications for use, since both drugs are approved for use in prostatitis, sinusitis, respiratory and genitourinary infections. Moreover, both medicines are available over the counter.

When asked whether Tavanic or Levofloxacin is better, it is also important to note the cost of the first drug, which can reach up to 1200 rubles, which will be significantly higher than the average price for Levofloxacin.

Another analogue of Levofloxacin, which has a similar therapeutic effect, is the drug Moxifloxacin. It has a pronounced antibacterial effect against infectious agents of different classes.

Compared to Levofloxacin, Moxifloxacin has the following advantages:

• The drug has a wider spectrum of action.
• Does not provoke allergies when exposed to ultraviolet radiation.
• It can be used in conjunction with other antibiotics without causing negative reactions.

In turn, the following disadvantages of this analogue are distinguished in comparison with Levofloxacin:

• Less effective for urinary tract infections.
• Does not have complete reception security.
• It has a large list of contraindications.
• It has a bad effect on the metabolism of vitamins when taken.

As for eye drops, Levofloxacin in this form of release has analogues in the form of Floxal, Signicef ​​and Ofloxacin. It is allowed to use these drugs only as directed by a doctor, with strict adherence to the dosage. If treatment is necessary for children, it is important that the therapy is supervised by a specialist.

Remember that self-medication is dangerous to your health! Be sure to consult your doctor! The information on the site is presented solely for popular informational purposes and does not claim to be reference and medical accuracy, is not a guide to action.

Which is better: ciprofloxacin or levofloxacin?

To date, in otolaryngology and pulmonology, various antibacterial agents are considered one of the main drugs. Due to their high efficiency, drugs from the fluoroquinolone group are quite often prescribed for the treatment of ENT diseases and respiratory infections. In this article we will try to figure out which is better than levofloxacin or ciprofloxacin. To give a thorough answer, one should dwell in more detail on the features of the use of each of these drugs separately.

Ciprofloxacin

Ciprofloxacin belongs to the classical fluoroquinolones, which have wide indications for use in respiratory infections of the lower respiratory tract and ENT pathology. Clinical experience shows that this drug is active against gram-negative bacteria, staphylococci and atypical pathogens (chlamydia, mycoplasma, etc.). At the same time, Ciprofloxacin is not effective enough for diseases caused by pneumococci.

The selection of the optimal drug for the treatment of any disease should be dealt with exclusively by a highly qualified doctor.

Indications

As a broad-spectrum antibacterial drug, Ciprofloxacin is successfully used in the treatment of patients suffering from respiratory infections of the respiratory tract and ENT pathology. For what diseases of the respiratory system and diseases of the ear, throat, nose, this drug from the group of classic fluoroquinolones is used:

1. Acute and chronic bronchitis (at the stage of exacerbation).
2. Pneumonia caused by various pathogenic microorganisms.
3. Inflammation of the middle ear, sinuses, throat, etc.

Contraindications

Like most drugs, Ciprofloxacin has its own contraindications. In what situations this representative of classical fluoroquinolones cannot be used in the treatment of respiratory diseases and ENT pathology:

• Allergic reaction to Ciprofloxacin.
• Pseudomembranous colitis.
• Childhood and adolescence (until the end of the formation of the skeletal system). The exception is children with pulmonary cystic fibrosis who have developed infectious complications.
• Pulmonary anthrax.

In addition, patients with the following disorders and pathological conditions have restrictions on the use of Ciprofloxacin:

• Progressive atherosclerotic lesions of the blood vessels of the brain.
• Severe cerebral circulation disorders.
• Various heart diseases (arrhythmia, heart attack, etc.).
• Decreased levels of potassium and / or magnesium in the blood (electrolyte imbalance).
• Depressive state.
• Epileptic seizures.
• Severe central nervous system disorders (eg, stroke).
• Myasthenia gravis.
• Serious malfunction of the kidneys and / or liver.
• Advanced age.

Side effects

According to clinical practice, adverse reactions in the prevailing majority of patients taking fluoroquinolones are infrequent. Let's list the undesirable effects that occur in about 1 in 1000 patients taking Ciprofloxacin:

• Dyspeptic disorders (vomiting, pain in the abdomen, diarrhea, etc.)
• Decreased appetite.
• Feeling of heartbeat.
• Headache.
• Dizziness.
• Recurrent sleep problems.
• Changes in the main indicators of blood.
• Weakness, fatigue.
• Allergic reaction.
• Various skin rashes.
• Painful sensations in muscles and joints.
• Functional disorders of the kidneys and liver.

Do not buy Levofloxacin or Ciprofloxacin without first talking to your healthcare professional.

special instructions

With extreme caution, Ciprofloxacin is prescribed to patients who are already taking medications that lead to an extension of the QT interval:

1. Antiarrhythmic drugs.
2. Antibiotics from the macrolide group.
3. Tricyclic antidepressants.
4. Antipsychotics.

Clinical observations show that Ciprofloxacin enhances the effect of hypoglycemic drugs. With their simultaneous use, careful monitoring of blood glucose should be carried out. It is recorded that drugs that reduce acidity in the gastrointestinal tract (antacids), and containing aluminum and magnesium, reduce the absorption of fluoroquinolones from the digestive tract. The interval between the use of an antacid and an antibacterial drug should be at least 120 minutes. I would also like to note that milk and dairy products can affect the absorption of Ciprofloxacin.

In case of an overdose of the drug, the development of headache, dizziness, weakness, convulsive attacks, dyspeptic disorders, functional disorders of the kidneys and liver is possible. There is no specific antidote. The stomach is washed, activated charcoal is given. If necessary, symptomatic therapy is prescribed. Closely monitor the patient's condition until complete recovery.

Levofloxacin

Levofloxacin belongs to the third generation fluoroquinolones. Possesses high activity against gram-negative bacteria, pneumococci and atypical pathogens of respiratory infections. Most pathogens that show resistance (resistance) to the "classic" second-generation fluoroquinolones may be susceptible to more modern drugs such as Levofloxacin.

Food intake does not affect the absorption of Ciprofloxacin or Levofloxacin. Modern fluoroquinolones can be taken either before or after meals.

Indications

Levofloxacin is a broad-spectrum antibacterial drug. It is actively used for the following diseases of the respiratory system and ENT organs:

• Acute or chronic inflammation of the bronchi (at the stage of exacerbation).
• Inflammation of the paranasal sinuses (sinusitis, sinusitis, etc.).
• Infectious and inflammatory processes in the ear, throat.
• Pneumonia.
• Infectious complications of cystic fibrosis.

Contraindications

Despite the fact that Levofloxacin belongs to the new generation of fluoroquinolones, this drug can not be prescribed in all cases. What are the contraindications to the use of Levofloxacin:

• Allergic reaction to the drug or its analogues from the fluoroquinolone group.
• Serious kidney problems.
• Epileptic seizures.
• Tendon damage associated with previous fluoroquinolone therapy.
• Children and adolescents.
• Periods of childbearing and breastfeeding.

Levofloxacin should be prescribed with extreme caution in elderly patients.

Side effects

As a rule, all adverse reactions are classified according to the severity and frequency of occurrence. Let's list the main undesirable effects from taking Levofloxacin that may occur:

• Problems with the functioning of the gastrointestinal tract (nausea, vomiting, diarrhea, etc.).
• Headache.
• Dizziness.
• Allergic reactions (skin rash, itching, etc.).
• The level of essential liver enzymes rises.
• Drowsiness.
• Weakness.
• Pain in muscles and joints.
• Tendon damage (inflammation, tears, etc.).

Self-administration of Levofloxacin or Ciprofloxacin without the permission of the attending physician can have serious consequences.

special instructions

Since the likelihood of joint damage is high, Levofloxacin is not prescribed in childhood and adolescence (up to 18 years), with the exception of extremely severe cases. When using antibacterial drugs for the treatment of elderly patients, it should be borne in mind that this category of patients may have impaired renal function, which is a contraindication for prescribing fluoroquinolones.

During therapy with Levofloxacin, patients who have previously suffered a stroke or severe traumatic brain injury may develop epileptic seizures (convulsions). If you suspect the presence of pseudomembranous colitis, you must immediately stop taking Levofloxacin and prescribe the optimal course of therapy. In such situations, it is strongly discouraged to use drugs that inhibit intestinal motility.

Although rare, there may be cases of tendon inflammation (tendonitis) when using Levofloxacin. Older patients are more prone to this kind of adverse reactions. Concomitant use of glucocorticosteroids significantly increases the risk of tendon ruptures. If you suspect a tendon lesion (inflammation, ruptures, etc.), fluoroquinolone therapy is discontinued.

In case of an overdose of this drug, symptomatic therapy should be carried out. The use of dialysis in such cases is ineffective. There is no specific antidote.

During therapy with Levofloxacin, it is not recommended to engage in activities that require increased concentration of attention and a quick reaction (for example, driving). In addition, due to the risk of developing photosensitization, refrain from excessive exposure of the skin to ultraviolet rays.

Which drug should you choose?

How to determine which is better than Levofloxacin or Ciprofloxacin? Of course, only an experienced specialist can make the best choice. Nevertheless, when choosing a drug, it is necessary to rely on 3 main aspects:

A good drug is one that is not only effective, but also less toxic and available. In terms of effectiveness, Levofloxacin has its advantages over Ciprofloxacin. Along with the preserved activity against gram-negative pathogenic microorganisms, Levofloxacin has a more pronounced antibacterial effect against pneumococci and atypical pathogens. Nevertheless, it is inferior to Ciprofloxacin in activity against the pathogen Pseudomonas (P.) aeruginosa. It has been noted that pathogens that are resistant to Ciprofloxacin may be sensitive to Levofloxacin.

The type of pathogen and its sensitivity to antibacterial agents are decisive when choosing the optimal fluoroquinolone (in particular, Ciprofloxacin or Lefovloxacin).

Both drugs are well absorbed in the intestine when taken orally. Food practically does not affect the absorption process, with the exception of milk and dairy products. They are convenient to use because they can be prescribed 1-2 times a day. Regardless of whether you take Ciprofloxacin or Levofloxacin, in rare cases, unwanted side reactions may develop. As a rule, dyspeptic disorders (nausea, vomiting, etc.) are noted. Some patients taking second or third generation fluoroquinolones complain of headache, dizziness, weakness, increased fatigue, and sleep disturbance.

In elderly patients, especially with glucorticosteroid therapy, tendon ruptures are possible. Due to the risk of developing joint lesions, fluoroquinolones are limited in use during periods of gestation and breastfeeding, as well as during childhood.

Currently, for most patients, the price aspect is of paramount importance. A package of Ciprofloxacin tablets costs about 40 rubles. Depending on the dosage of the drug (250 or 500 mg), the price may fluctuate, but not significantly. More modern Levofloxacin will cost you an average of 200-300 rubles. The price will depend on the manufacturer.

At the same time, the final decision as to which is best for the patient, Ciprofloxacin or Levofloxacin, is made exclusively by the attending physician.

Which is better - Ofloxacin or Ciprofloxacin? How not to make a mistake with the choice?

Ofloxacin is a second generation antibacterial drug from the group of fluoroquinolones. Pharmacological agents of this group are an alternative to broad-spectrum antibiotics.

Due to the structure and mechanism of action, the drug has a high bactericidal activity in relation to gram-negative and gram-positive microorganisms.

The main advantage of Ofloxacin is that it is effective in deactivating microflora that is resistant to other antibiotics.

The use of Ofloxacin

The antibiotic has been successfully used to treat various diseases. The drug is used to treat infectious pathologies of the respiratory tract (including pneumonia, bronchitis). The drug is widely used in otorhinolaryngology for the treatment of sinusitis, pharyngitis, otitis media, laryngitis, tracheitis.

Photo 1. Packaging of Ofloxacin in the form of tablets with a dosage of 200 mg. Producer "Darnitsa".

In infectious diseases of the skin (for example, with furunculosis, carbunculosis, phlegmon), the drug shows high efficiency. Ofloxacin copes with the treatment of infections of the osteoarticular apparatus, gastrointestinal tract, small pelvis (for example, salpingitis, oophoritis).

The antibiotic is used in nephrology and urology for the treatment of pyelonephritis, cystitis, urethritis. Among the pathologies of the venereal profile, the drug is used to treat gonorrhea, chlamydia. An antibacterial drug is prescribed to prevent the development of infectious pathologies with immunodeficiencies (including HIV).

In ophthalmic practice, the drug shows high efficiency in the fight against conjunctivitis, keratitis, blepharitis, iritis, complications after trauma to the organ of vision.

Reference. An antibacterial drug is used to treat tuberculosis in combination with other drugs.

Contraindications

Ofloxacin has some contraindications for use:

• status epilepticus;
• pathology of the functions of the nervous system (meningitis, encephalitis in history);
• the state of pregnancy;
• fermentopathy of glucose-6-phosphate dehydrogenase.

The drug is contraindicated in children under the age of 18, since the growth of the skeleton has not yet been completed by this time. Patients with diagnoses of atherosclerosis of the cerebral arteries, impaired blood circulation in the brain, chronic kidney disease should limit the prescription of the antibiotic to a minimum dosage.

Side effects

From the gastrointestinal tract, the following side reactions may occur:

• anorexia state;
• feeling of nausea;
• defecation disorders (often in the form of diarrhea);
• bloating;
• pain in the abdominal region;
• hyperactivity of liver enzymes;
• excess bilirubin;
• development of jaundice due to cholestasis.

From the side of the central nervous system, the following side reactions may occur:

• cephalalgia;
• convulsive tremors;
• dizziness;
• difficulty in movement;
• feeling of numbness in the limbs;
• increased anxiety;
• depressive disorders;
• a feeling of double vision;
• changes in taste perception.

On the part of the musculoskeletal system, the following side reactions may occur:

• muscle pain;
• joint pain;
• inflammation of the synovial sheaths and tendons.

From the side of the cardiovascular system, the following side reactions may occur:

• vascular inflammation;
• an increase in the frequency of myocardial contractions;
• significant drop in pressure up to collapse.

On the part of the skin, the following side reactions may occur:

• petechial hemorrhages;
• dermatitis;
• rash in the form of papules;
• vascular inflammation.

From the side of the hematopoietic system, the following side reactions may occur:

• decrease in leukocytes;
• the development of agranulocytosis;
• the development of anemia;
• decreased platelets;
• decrease in the work of all sprouts of hematopoiesis.

From the urinary system, the following side reactions may occur:

• sharp nephritis;
• impaired renal function;
• increased blood creatinine;
• excess urea.

The manifestation of allergic diseases is possible in the form of:

• hives;
• Quincke's edema;
• skin rash;
• allergic pneumonitis;
• allergic nephritis;
• anaphylaxis (extremely rare).

Composition

One tablet of an antibacterial agent consists of 400 mg of ofloxacin as an active ingredient, corn starch, cellulose, talc, povidone, calcium stearate, aerosil.

Levofloxacin

Levofloxacin is a synthetically created fluoroquinolone antibiotic. The isomeric analogue of ofloxacin acts as the active substance of the drug.

Composition

One levofloxacin tablet consists of 250 mg of levofloxacin hemihydrate.

Photo 2. Packages of Levofloxacin in the form of tablets with a dosage of 250 and 500 mg. Manufacturer "Dalkhimpharm".

Indications

Indications for the use of Levofloxacin are infectious diseases caused by sensitive microflora:

• acute sinusitis;
• chronic bronchitis in the acute stage;
• pneumonia;
• urinary tract infections;
• prostatitis;
• infectious skin lesions;
• infections of the gastrointestinal tract.

Contraindications

Contraindications include: hypersensitivity to fluoroquinolones, status epilepticus, renal failure, pregnancy and lactation.

The drug is contraindicated in children and adolescents.

Side effects

On the part of the gastrointestinal tract, such side reactions as changes in the act of defecation (in the form of diarrhea), flatulence, and abdominal pain may occur. These effects are rare and occur in 1% of cases.

From the side of the central nervous system, there may be side effects such as cephalgic pain, patients sometimes feel dizzy, and the cycle of sleep and wakefulness is disrupted.

Fatigue appears, work capacity and stress resistance decrease.

On the part of the musculoskeletal system, pain of muscle and articular origin may be noted. A pain syndrome of this nature is subjectively felt by a person as body aches.

Negative effects on the part of the cardiovascular system manifest themselves infrequently and are expressed in vascular inflammation, an increase in the frequency of myocardial contractions, a significant decrease in pressure up to collapse.

On the part of the skin, petechial hemorrhages, dermatitis, rash in the form of papules, and vascular inflammation are possible.

Rarely, allergic diseases such as urticaria and skin rashes occur. Anaphylaxis and Quincke's edema are extremely rare.

Important! Levofloxacin is widely used in phthisiology for the treatment of tuberculosis. It is a reserve medicine and is only used if the Koch bacillus strain is highly resistant to other drugs.

Levofloxacin or Ofloxacin: which is better

The activity of Levofloxacin against microorganisms is twice that of Ofloxacin. The period of half excretion of the substance from the body lasts about 6 hours, and ofloxacin - about 5.

The drugs differ in dosage. For the treatment of infectious pathologies of the respiratory tract, 200 mg of Ofloxacin is prescribed twice a day. For the treatment of a similar pathology, 500 mg of Levofloxacin is required once a day. This creates a concentration of Levofloxacin 2.5 times higher than Ofloxacin.

Ciprofloxacin

Ciprofloxacin is an antimicrobial drug with a wide range of effects; it also belongs to fluoroquinols. The drug has a bactericidal effect.

Composition

One antibiotic tablet contains 250 mg of ciprofloxacin as active ingredient. The list of excipients consists of cellulose, hypromellose, croscarmellose, polysorbate, stearate.

Photo 3. Packaging of Ciprofloxacin in the form of tablets with a dosage of 500 mg. Producer "Actavis".

Indications

Indications for prescribing a medication are infectious pathologies of various systems:

• respiratory tract;
• ENT organs;
• urinary system;
• reproductive system;
• gastrointestinal tract;
• skin;
• musculoskeletal system.

The drug is used to prevent infections with immunodeficiency.

Contraindications

Contraindications include high sensitization to drugs of the fluoroquinolone group. The medicine should not be used to treat patients with status epilepticus. Lack of kidney and liver function makes taking Ciprofloxacin unacceptable.

Attention! During gestation and lactation, it is strictly forbidden to take any drugs from the group of fluoroquinolones.

The medication is contraindicated in children and adolescents. For older people, there is a high risk of renal disease while taking an antibiotic.

Side effects

Patients most often tolerate Ciprofloxacin without adverse effects. Allergic manifestations (itching, rash) are rarely noted, Quincke's edema rarely develops.

Photo 4. Quincke's edema in a woman. May cause suffocation in some cases.

Appetite may disappear, soreness in the epigastrium, diarrhea, and malaise may be felt. Sometimes sleep is disturbed, cephalgic syndrome develops. Perception of taste and odors may be impaired.

Important! Ciprofloxacin is successfully used by phthisiatricians for the treatment of tuberculosis. As an agent from the reserve group, the antibiotic shows a high effect against resistant colonies of tuberculosis bacteria.

Differences between Ciprofloxacin and Ofloxacin

Ciprofloxacin is a first generation fluoroquinolone medication. Unlike Ofloxacin, the spectrum of its effects is narrower, since more bacteria are resistant to it. Ciprofloxacin and Ofloxacin are similar in mechanism of action and structure, but have a number of differences. The activity of Ciprofloxacin against microorganisms exceeds that of Ofloxacin.

The drugs differ from each other in effective doses. For the treatment of infectious diseases of the respiratory system, 200 mg of Ofloxacin is prescribed twice a day. For the treatment of a similar pathology, 400 mg of Ciprofloxacin is required once a day. Ciprofloxacin has fewer side effects than Ofloxacin.

Ofloxin and Ofloxacin: are they the same thing or is there a difference?

In order to find out whether there is a difference in the drugs Ofloxin and Ofloxacin, it is necessary to analyze their composition, compare the contraindications and side effects of antibiotics.

Composition

Ofloxin is an analogue of Ofloxacin. The composition contains 200 mg of ofloxacin as an active ingredient. Excipients: corn starch, cellulose, talc, povidone, calcium stearate, aerosil.

Photo 5. Packaging of Ofloxin in the form of tablets with a dosage of 400 mg. Manufacturer "Zentiva".

Application

The drug is used in the treatment of:

• respiratory tract infections (including pneumonia, bronchitis);
• otorhinolaryngological diseases (sinusitis, pharyngitis, otitis media, laryngitis, tracheitis);
• infections of the skin (for example, with furunculosis, carbunculosis, phlegmon);
• diseases of the osteoarticular apparatus;
• ailments of the gastrointestinal tract;
• pelvic infections (eg, salpingitis, oophoritis);
• urological pathologies (pyelonephritis, cystitis, urethritis);
• sexually transmitted infections (gonorrhea, chlamydia).

Contraindications

Epilepsy and high sensitization to quinolones are contraindications to the use of Ofloxin.

It is forbidden to prescribe an antibiotic for pregnant women, as well as women in the lactation period.

In case of impaired renal function at the beginning of therapy, the usual dosages are prescribed, and later they are reduced, taking into account the creatinine clearance rates.

Side effects

Adverse reactions are manifested in the form of dyspeptic disorders, appetite disappears, epigastric pain, diarrhea are noted. In the blood plasma, the concentration of bilirubin increases. Anemic conditions may develop with increased fatigue, apathy.

The reaction speed slows down during complex work. Sleep is disturbed, dizzy, hallucinations are extremely rare.

Ofloxin and Ofloxacin are complete structural analogs, and there are no differences between them.

Comparison of drugs: rational choice of antibiotics from the group of fluoroquinolones

Ofloxacin and Ofloxin are the same medicine. Levofloxacin is an isomer of Ofloxacin and differs from the latter in a number of properties. To achieve the effect, a smaller dose of the drug is needed, therefore the choice of Levofloxacin is preferable.

Ciprofloxacin is the first generation of fluoroquinolones, it is less effective in use than Ofloxacin and Levofloxacin, since a larger number of microorganisms managed to form resistance to it. With regard to tuberculosis and severe infectious pathologies, Levofloxacin shows the highest effect.

Useful video

Watch the video review of the packaging of Ofloxacin, which is produced by Lekhim.

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An online magazine about tuberculosis, lung diseases, analyzes, diagnostics, medications and other important information about this.

One of the most important directions in the treatment of urological pathology of the male gland is the use of antibiotics. A huge breakthrough for doctors and patients was the invention of fluoroquinolones - a special class of antibacterial agents with the ability to penetrate directly into the tissue of the damaged organ.

At the moment, levofloxacin for prostatitis is considered the gold standard in its treatment.

A new generation of antimicrobial agents has emerged from the wrong approach to the use of similar drugs in the past. Inadequate dosages, too short courses of therapy, the choice of the wrong group of drugs ensured the emergence of a mass of resistant bacterial strains.

It is when the usual antibiotic does not help, you need to choose Levofloxacin. Its main advantages are:

1. A wide range of therapeutic actions (Streptococcusagalactiae, Staphylococcusepidermidis, Staphylococcusaureus, Streptococcuspneumoniae, Streptococcuspyogenes, Listeriamonocytogenes, Chlamydiapneumoniae and many others).
2. Better penetration directly into the prostate tissue. Approximately 92% of the dose is accumulated in the gland.
3. Excellent bioavailability and speed of action. The maximum concentration in the blood is reached after 1.5 hours.
4. The same dosage of the medication for oral and parenteral administration.
5. Intracellular action, which makes it possible to destroy atypical microbes.

Thanks to these properties, fluoroquinolone becomes the basis for healing from prostatitis. It gained its effectiveness thanks to a special levorotatory formula and the ability to block the DNA gyrase enzyme of a microbial cell.

As a result, the bacterium is unable to correctly reproduce the genetic structure, damage to the cytoplasm, membrane occurs, and the microorganism dies.

The drug has a very wide range of applications in addition to inflammation of the male organ. It is excellent for treating bacterial diseases of the urinary system, abdominal organs, community-acquired pneumonia, sepsis and other infectious processes.

"Salutem Pro" - male strength and health at any age! Development of Israeli scientists from prostatitis! "Salutem pro" - a plant complex from Israel, thanks to its unique composition, will help you in the shortest possible time.

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Levofloxacin for prostatitis is most often used in tablets with a dosage of 0.25-0.5 g or infusion in 100 mg vials, which contain 0.5 g of the active ingredient.

After therapy with this agent, the following effects are observed:

• Suppression of the focus of inflammation;
• Reducing edema;
• Pain regression;
• Normalization of local and general body temperature;
• Elimination of pathological microflora from the gland tissue.

Treatment of prostatitis with Levofloxacin for patients is most convenient in the form of oral pills. The daily dose of the drug is 500 mg.

The medicine is inactive in relation to food, therefore, it practically does not matter when to drink it, but it is recommended to use it between lunch and dinner once or twice a day - it all depends on the stage of neglect of the disease that the patient has acquired. Be sure to drink 0.5 or 1 glass of water.

Do not chew the tablets. The course of treatment is 28 days.

Injections have the same mode of use, but due to the constant need for injections, they remain unclaimed by patients with inflammation of the prostate gland.

Particular attention should be paid to situations when the patient has concomitant renal failure or other diseases of this system. Since 75% of the drug is excreted in the urine, violations of this process can significantly aggravate the course of the underlying disease.

For such people, you need to reduce the dose by half while maintaining the antibiotic regimen and observe the occurrence of any negative changes in dynamics.

Levofloxacin for chronic prostatitis or any other form of ailment is one of the safest remedies.

However, in rare cases, such negative reactions are possible:

1. Nausea, diarrhea, vomiting;
2. Drop in blood pressure, tachycardia;
3. Dizziness, headache, general weakness, sleep disturbances;
4. Tremors, anxiety, depression;
5. Muscle and joint pain, tendovaginitis.

In addition, there are a number of contraindications for the use of this antibacterial drug:

1. Tendon and joint problems after any history of fluoroquinolone use;
2. The patient's age is up to 18 years;
3. Epileptic seizures, Jacksonian epilepsy;
4. Allergic reactions to the constituent components of the drug;
5. Renal failure stage IV-V.

Levofloxacin is one of the best options for the etiological treatment of bacterial prostatitis. However, self-medication is highly undesirable. Before use, it is imperative to undergo an examination of the whole body and consult a specialist to select an adequate dose and therapy regimen.

With bacterial prostatitis, it is impossible to get rid of the pathology without eliminating the pathogenic agents that provoked the inflammatory process. Despite the bias of patients towards the use of antibiotics, only properly selected antibiotic therapy helps to get rid of male pathology of an infectious nature.

Coping with the bacterial form of prostatitis can only be done with antibiotics.

How to find the right antibiotic

Absolutely different pathogenic and opportunistic organisms can act as agents provocateurs in prostatitis, which can multiply rapidly and cause inflammatory reactions in the organ. To suppress the vital activity of such particles, antimicrobial drugs are used.

However, the effect of medications is designed to destroy certain groups of bacteria. In order to choose the right effective remedy for prostatitis, it is necessary to determine the type of microbes and their sensitivity to antibacterial drugs.

For this, a bacterial culture of the secretion of the prostate gland is carried out. Based on the results obtained, the appropriate antibiotic can be selected.

• anaerobic gram-positive bacteria;
• anaerobic gram-negative agents;
• simple anaerobic microorganisms;
• other bacteria.

For the treatment of prostatitis, a course with Levofloxacin is prescribed

Levofloxacin shows good results, both in the treatment of acute forms of pathology, and in chronic prostatitis of a bacterial nature.

Levofloxacin, due to its ability to kill disease-causing particles at any stage of development, is an effective bactericidal drug. Unlike bacteriostatic drugs that stop the reproduction of microbes, that is, they affect only cell division, Levofloxacin destroys cells, both dividing and growing, and in a state of rest. Therefore, the drug is considered to be quite effective, with a wide range of action.

The mechanisms of the drug work correspond to the basic properties of the group of quinols, fluoroquinols. The drug, penetrating into the disease-causing cells, blocks the activity of certain enzymes involved in the formation of DNA. Due to pathological changes in the cell, processes develop that are incompatible with the life of microbes.

In this case, bacteria not only lose their ability to reproduce, but also finally die. Thus, the drug can have a detrimental effect on most of the disease-causing particles found in prostatitis.

The drug is effective against bacteria

The drug is quite often prescribed for exacerbations of pathology, chronic course of the disease, since, penetrating into the places of greatest accumulation of pathogenic agents, it is able to effectively eliminate them and contribute to a complete cure.

The lack of effect can be observed only in the treatment of a disease caused by bacteria that do not belong to the group of sensitive agents to levofloxacin.

Levofloxacin is found in the form of a tablet preparation and a solution for injection.

The medicinal solution contains 0.5% of the active ingredient, supplemented with:

• disodium edetate dihydrate;
• sodium chlorine;
• deionized water.

The solution is transparent with a yellowish or yellow-green tint.

The drug is available in various forms

The tablet form of the drug is found with a content of 500 mg of the medicinal substance. You can also find tablets with 250 mg of the main ingredient and additives in the form of:

• microcrystalline cellulose;
• hypromellose;
• iron oxide;
• titanium dioxide;
• primellose;
• calcium stearate.

Round tablets with a white top shell.

In the treatment of prostatitis caused by various pathogenic agents, Levofloxacin is often used. It is allowed to use both a tablet preparation and an intravenous solution. Regardless of the selected method of using the drug, therapy for prostatitis is carried out for 28 days.

For the treatment of severe prostatitis, the drug is used in the form of injections

So, in case of severe prostatitis, Levofloxacin is administered intravenously for the first week of treatment, or even 10 days. A single dosage is prescribed up to 500 ml daily. Further therapy continues with pills. It is recommended to take 1 tablet daily containing 500 mg of the medicinal component. The course should total 4 weeks with intravenous administration of the drug.

You can treat prostatitis without injections. With this option of therapy, pills are taken throughout the course. Men with prostatitis are prescribed a daily pill containing 500 mg of the drug.

Attention! In the absence of significant improvements, it is advisable to re-culture to identify the sensitivity of bacteria to the drug.

• with personal intolerance to the ingredients of the medicine;
• in the presence of allergic reactions;
• with renal failure;
• patients under 18 years of age;
• if inflammation of the tendons was previously observed with previous doses of such drugs;
• patients with epilepsy.

Renal failure is the reason for refusing treatment with Levofloxacin

There are also relative contraindications. The drug must be prescribed with caution when:

• severe renal dysfunction;
• glucose-6-phosphate dehydrogenated deficiency.

Such pathologies require close medical supervision during therapy with levofloxacin for prostatitis.

Taking Levofloxacin, you must strictly adhere to the dosages recommended by doctors. With uncontrolled intake of the drug in excess of safe doses, it is possible that:

• confusion and seizures;
• dizziness and loss of consciousness;
• nausea;
• erosion of mucous coatings;
• changes in the rhythm of the heartbeat.

In case of an overdose of the drug, the heart rhythm may be disturbed

In case of an overdose, treatment is used to eliminate the corresponding symptoms. Any methods of accelerating the withdrawal of the drug do not bring results.

Attention! Levofloxacin, when taken for a long time, can cause dysbiosis and promote the rapid multiplication of fungal organisms. To prevent such pathologies, it is recommended to take drugs containing beneficial bacteria and antifungal drugs.

In the form of negative consequences, symptoms can often be observed in the form of:

• diarrhea;
• nausea;
• increased activity of liver enzymes.

A side effect of the drug may be diarrhea.

Less common signs of complications are:

• itchy skin or redness;
• digestive abnormalities in the form of lack of appetite, belching, heartburn, vomiting;
• soreness in the abdomen;
• headaches or dizziness;
• numbness or drowsiness;
• general weakness and sleep disturbances.

Reactions in the form of:

• hives;
• shock state;
• bronchospasm and suffocation;

  Less commonly, you may experience pressure problems while taking the drug.

  If any signs of side effects appear, taking the drug must be urgently stopped before consulting a doctor. When alarming symptoms that threaten life appear, an urgent appeal to doctors is required.

  With the simultaneous administration of Levofloxacilin with anti-inflammatory nonsteroidal drugs in the form of Ibuprofen, Nimesulide, Paracetamol, Aspirin, the risk of seizures increases. Such a reaction is observed with the combined use of Fenbufnom, Theophylline.

  The effectiveness of the drug is influenced by antacids in the form of Almagel, Rhenia, Phosphalugel, as well as iron salts. It is recommended to take these drugs with a time difference of at least 2 hours.

  Take other medicines in parallel with Levofloxacilin with caution

  When taking glucocorticoid drugs in the form of Hydrocortisone, Prednisolone, Methylprednisolone, Dexamethasone, Betamethasone against the background of Levofloxacin, tendon ruptures may occur.

  Attention! It is strictly forbidden to take alcoholic beverages together with an antibacterial drug. This combination provokes an increase in side effects associated with the functioning of the central nervous system.

  Treatment of prostatitis with antibacterial drugs can relieve a man of provoking factors in the form of pathogens, but does not eliminate stagnant effects, no less influencing the development of pathology.

  More information about the drug can be found in the video:

  With prostatitis, it is customary to use a large number of medications, because there is a need for a large number of therapeutic actions. It is required to improve blood circulation, facilitate urination, increase potency, etc. When the disease has an infectious nature, first of all, they try to limit the multiplication of pathogenic microorganisms and destroy them. Levofloxacin has a similar effect. It is used when a man experiences the following symptoms:

  • Pain when urinating
  • Frequent urge to use the toilet, especially at night
  • Painful ejaculation
  • Weakening of an erection
  • Temperature rise (37 to 40 degrees)
  • General weakness

  The stronger the inflammatory process, the more vividly these symptoms manifest themselves. At the stage of exacerbation, the patient may even be hospitalized, tk. pills alone can not cope with acute urinary retention or pain. Antibiotics are used after tests that will show which pathogens have appeared in the prostate gland.

  Levofloxacin has a wide spectrum of actions and is effective against a large number of bacteria. The patient can get it only with a prescription from the attending physician.

  Reviews of Levofloxacin for prostatitis are mostly positive, both from patients and from specialists. He copes well with the declared diseases, in the instructions he has indications for admission:

  1. Infectious pathologies of the abdominal region
  2. Chronic bronchitis and its exacerbation
  3. Pneumonia
  4. Prostatitis, urethritis
  5. Pyelonephritis
  6. Skin and soft tissue infections

  For some infections, the use of Levofloxacin is possible only when other antibiotics have been ineffective, because it has a very powerful effect. In the form of eye drops, it can be prescribed for superficial eye infections, to prevent complications after surgery or eye procedures.

  Levofloxacin is a fluoroquinolone antibiotic, which means that it has a bactericidal, not bacteristatic effect on microorganisms. The difference between them is that in the first case the bacteria are destroyed, and then the second stops their reproduction and growth. The mechanism of the drug's work looks like this: the synthesis of the DNA of the pathogenic cell is disrupted, its genetic code is disrupted and it dies. Moreover, the destruction occurs to such an extent that it has no opportunity to recover. They also have the property of influencing the "copying" of cells, which becomes impossible after exposure to one enzyme.

  Thus, the likelihood of bacteria developing drug resistance is significantly reduced, because they cannot reproduce. Among the positive actions of Levofloxacin are also:

  • Excellent penetration into organ tissues, into cells
  • Destruction of pathogens with minimal release of toxins from them
  • Reducing swelling, relieving pain, normalizing temperature
  • Good combination with other antibiotics (macrolides, penicillins)
  • Long elimination period (allows taking 1 tablet per day)

  Among the various pathogens, the least resistant to the drug are anaerobic gram-positive and gram-negative bacteria, microorganisms. These include:

  1. Staphylococci
  2. Streptococci
  3. Haemophilus influenzae
  4. Peptostreptococci
  5. Moraxella catarrhalis bacterium

  Chlamydia, legionella, mycoplasma, ureaplasma are also considered sensitive. The course of treatment with Levofloxacin for prostatitis may be possible if the disease is caused by enterococci, enterobacteria, Pseudomonas aeruginosa, Morgan bacteria, but they can acquire resistance to the main substance of the drug - levofloxacin hemihydrate. It is absorbed into the body very quickly, absorption is not affected by food intake.

  The maximum concentration of the element is reached after 1-2 hours and is excreted about 16 hours, completely excreted from the body with urine after 2 days. The higher the dosage, the longer it takes.

  The method of administration of the drug can be oral or intravenous. Levofloxacin tablets contain 250 or 500 mg of active substance, ampoule with solution - 100 ml. The instructions for use state that the capsules must be taken as follows:

  • Half or a whole tablet (250-500 mg) 1 time per day
  • Preferably taken before or after meals
  • Drink at least half a glass of water

  Continue taking from 3 days to 2-4 weeks. With pneumonia or bronchitis, it can be from 7 to 14 days, with skin infections - the same, and with urinary tract infections - from 3 to 10 days. It is undesirable to start taking pills until the body temperature has stabilized. It is always recommended to repeat the technique at the same time.

  The likelihood that Levofloxacin does not help with prostatitis is very small. The drug is too strong in order not to respond to pathogens, and if they were immediately resistant to it, the doctor should have initially prescribed another medication.

  Limitations to the use of Levofloxacin are indications that apply to almost all antibiotics - hypersensitivity to components, childhood, pregnancy and lactation. However, due to the high toxicity of this agent, a few more points can be added:

  1. Having epilepsy
  2. Tendon Disorders from Other Fluoroquinolones
  3. Pseudoparalytic myasthenia gravis

  Restrictions on intake may occur in patients with a predisposition to seizures, glucose-6-phosphate dehydrogenase deficiency, impaired renal or liver function, and the elderly. Treatment of prostatitis with Levofloxacin may be contraindicated in the stronger sex with diabetes mellitus, psychosis, cardiovascular diseases. Side effects on the use of tablets or the introduction of a solution can appear both at standard dosages and when they are exceeded. More often than others appear:

  • Nausea and vomiting
  • Diarrhea
  • Headache
  • Drowsiness
  • Lower blood pressure
  • General weakness

  Among the side effects are also increased heart rate, convulsions and tremors, disorders of smell, vision, hearing. Rarely there are dyspepsia and abdominal pain, allergic reactions. The latter are characterized by rashes and urticaria, itching and burning. With an unknown frequency, photosensitivity may increase, hypo- or hyperglycemia, vascular collapse may occur. With intravenous administration, short-term pain at the injection site, inflammation, increased sweating is possible.

  In case of an overdose, such manifestations as nausea and vomiting, confusion, convulsions occur. If you find them, call an ambulance or immediately contact a specialist.

  The course of Levofloxacin for prostatitis is undesirable to combine with drugs such as antacids (aluminum and magnesium-containing), funds with iron in the composition - they reduce the effectiveness of the antibiotic. If it is necessary to take them, it is recommended to make an interval between doses of at least 2 hours. Deterioration of work is observed when the drug is combined with other quinolones, anticonvulsants, non-steroidal anti-inflammatory drugs. With simultaneous use with anticoagulants, the risk of bleeding increases, and together with insulin, hypo- and hyperglycemic states.

  Therefore, for patients with diabetes mellitus, it is necessary to constantly monitor blood glucose levels and observe the correct dosages. Due to the fact that Levofloxacin can cause severe allergic reactions, up to anaphylactic shock, you should be very careful when you take it for the first time and, if necessary, immediately consult a doctor. In case of renal or hepatic insufficiency, it is worth stopping the intake if symptoms of a worsening of the patient's condition appear.

  The drug does not interact with food, but it is forbidden to take it together with alcohol (most often, an aggravation of side effects from the central nervous system such as dizziness or numbness is noticed). It is necessary to store the packaging in a dry place where there is no access to sunlight. The shelf life of the tablets is 3 years, they are available from the pharmacy only with a prescription.

  An excellent video about taking Levofloxacin for inflammation of the prostate is located below. In it, the specialist talks about the results of treatment, possible complications, analogues of the drug.

  Treatment of inflammation of the prostate gland is carried out using a whole range of methods. Drug therapy is just one of them, but together with it it is necessary that the patient undergoes physiotherapy, diet and exercise therapy. Another technique, surgery, is used in extreme cases when medications have failed to help. Drugs for prostatitis are taken only after determining the cause of its development. If they were infectious agents, antibiotics like Levofloxacin are used, when blood stagnation or trauma is the culprit, other means are used.

  Typical for getting rid of prostatitis are anti-inflammatory nonsteroidal drugs, adrenolytics, muscle relaxants, hormonal drugs, pain relievers and vitamin complexes.

  One of the main tasks in treatment is to replenish the lack of nutrients in the body in order to raise immunity and help the prostate to regenerate tissues. For this purpose, rectal suppositories are often used, because it is easiest for them to bring substances to the prostate gland. What suppositories are popular for prostatitis:

  1. Prostatilen
  2. Prostopin
  3. Vitaprost
  4. Propolis DN
  5. Pumpkin
  6. Genferon

  Suppositories can have a wide range of therapeutic properties, which is why they are used so often. Only the procedure from use is unpleasant, but for recovery it is worth being patient. To strengthen the immune system, it is equally useful to start eating right, limiting or eliminating alcohol and cigarettes from your life. The patient's menu should contain fresh fruits and vegetables, herbs and dried fruits. The greatest benefit for men, both healthy and sick, will bring seafood, onions and garlic, parsley, cabbage, lean meats, fresh juices.

  It is better to refuse strong tea and coffee, because they can negatively affect potency. Semi-finished products, instant food, canned food, too fatty, salty or spicy food act in the same way. Sports activities will also affect immunity, but only regular ones. A set of exercises for prostatitis is easy to find on the Internet.

  Taking Levofloxacin for prostatitis with a course of treatment as prescribed by a leading specialist, you can cure the disease and get rid of unpleasant symptoms. Prostatitis is a problem in men of childbearing age. Disease associated with urination and sexual dysfunction causes psychological problems. Therefore, great importance is attached to its treatment.

  The onset of acute or chronic prostatitis is characterized by symptoms:

  1. Pain in the perineum.
  2. Disorder of urination.
  3. Sexual dysfunction.

  Prostatitis is divided into three conditional groups:

  • spicy;
  • chronic;
  • asymptomatic.

  Often prostatitis is a complication after inflammatory processes in the bladder. Before prescribing drugs for the treatment of prostatitis, it is necessary to examine the secret of the prostate to determine the causative agent of the inflammatory process.

  When examining patients with chronic prostatitis, they find:

  1. Ureaplasma.
  2. Mycoplasma.
  3. Chlamydia.
  4. Trichomonas.
  5. Gardnerells.
  6. Anaerobes.
  7. Candida mushrooms.

  Unfortunately, the results of bacteriological studies can be obtained no earlier than 5 days after the date of the analysis. To prevent the patient from suffering, he is prescribed antibiotics that act on most of the bacteria that cause prostatitis. These drugs include Levofloxacin. When the patient's condition improves, drug treatment is continued for 2 weeks. If there is no improvement, the antibiotic is changed, taking into account the results of microbiological studies.

  There are many causative agents that cause prostatitis. It is necessary to choose the right antibiotic to cure the disease. The wrong choice of antibiotic or interrupted prostatitis treatment can have negative health consequences. Under these conditions, resistance to a particular type of antibiotic is often developed. Prostatitis therapy is carried out for a long time, sometimes up to 8 weeks.

  It is necessary to treat chronic prostatitis with antimicrobial agents. They are prescribed even if no infection is found in the secret of the prostate.

  In such cases, the choice of a drug is determined by its pharmacological properties:

  1. Penetration of the drug into the tissue of the prostate gland.
  2. Creation of the necessary concentrations of the drug in the gland.

  Such properties are possessed by drugs of the fluoroquinolone group, in particular, Levofloxacin.

  The drug has the following properties:

  1. Has a wide range of antibacterial effects.
  2. It penetrates well into the prostate tissue.
  3. In large quantities it reaches the prostate gland.
  4. It can be administered as a tablet or infusion.
  5. Has good activity against pathogenic bacteria.

  Fluoroquinolones expand the treatment of prostatitis due to bacteria and microorganisms. They are used if no microbes are found in the prostate.

  Levofloxacin is a universal drug for the treatment of inflammatory processes

  Almost all inflammatory bacterial diseases of the male genitourinary system are treated with levofloxacin:

  1. Urinary tract infections.
  2. Bacterial prostatitis.
  3. Urethritis (inflammation in the urethra).
  4. Orchitis (testicular disease).
  5. Epididymitis (inflammation of the epididymis).

  Its clinical activity is 75%. The combination of an antibiotic in the treatment of prostatitis and a drug from the group of alpha-blockers gives a result of about 90%.

  Scope of application:

  1. Levofloxacin is capable of destroying pathogenic bacteria sensitive to it in any organs. In addition to treating infections associated with the genitourinary system, it is used to treat infections in other areas:
  2. Respiratory organs and ENT: tonsillitis, bronchitis, tracheitis, pneumonia, otitis media.
  3. Skin diseases: boils, bedsores, erysipelas.
  4. Peritonitis.
  5. Sepsis.

  The action is aimed at blocking the process of bacterial DNA synthesis. In the bacterial cell, changes occur that are incompatible with its vital activity. Under such conditions, microbes die. The drug is effective against a variety of microorganisms.

  Each infectious pathology is determined by one type of bacteria and is localized in one specific organ or system. To combat such a pathology, a drug is needed that acts on this particular type of bacteria. Drugs with a wide spectrum, act depressingly on several groups of such bacteria.

  The therapeutic effect in the treatment of prostate with Levofloxacin is achieved due to the continuation of its antimicrobial action on microorganisms, after its complete removal from the body. Of course, this depends on the type of microbes and the concentration of the drug obtained.

  The medicine is taken once a day. It is convenient and creates an advantage over other drugs.

  But, like most of these drugs, it has side effects:

  • nausea;
  • diarrhea;
  • dizziness;
  • insomnia.

  After the drug is discontinued, all side effects disappear. While taking it, it is not recommended to be in the sun or visit a solarium. Negatively affects the speed of psychomotor reactions. You must refuse to drive a car for the entire duration of the treatment.

  The most popular drugs include:

  1. Levofloxacin is a third generation antibiotic. It is used in cases of moderate infections. Release form: tablets, solution for infusion, eye drops.
  2. Moxifloxacin is a fourth generation antibiotic. Has a broader antibacterial effect. It is used in cases of very severe infections. This type of antibiotic should not be prescribed immediately after infection is diagnosed. Frequent use will lead to the development of a resistant species of bacteria to this group. Release form: solution for infusion.

  Levofloxacin is indicated for the treatment of any form of prostatitis. The greatest ease of use is taking a pill once a day. The course of drug treatment depends on the severity of the infection and its nature. The drug should not be discontinued before the full course. In case of accidental omission, the medication should be taken immediately, then be guided by the usual scheme.

In this article we will try to figure out which is better than levofloxacin or ciprofloxacin. To give a thorough answer, one should dwell in more detail on the features of the use of each of these drugs separately.

Ciprofloxacin

Ciprofloxacin belongs to the classical fluoroquinolones, which have wide indications for use in respiratory infections of the lower respiratory tract and ENT pathology. Clinical experience shows that this drug is active against gram-negative bacteria, staphylococci and atypical pathogens (chlamydia, mycoplasma, etc.). At the same time, Ciprofloxacin is not effective enough for diseases caused by pneumococci.

The selection of the optimal drug for the treatment of any disease should be dealt with exclusively by a highly qualified doctor.

Indications

As a broad-spectrum antibacterial drug, Ciprofloxacin is successfully used in the treatment of patients suffering from respiratory infections of the respiratory tract and ENT pathology. For what diseases of the respiratory system and diseases of the ear, throat, nose, this drug from the group of classic fluoroquinolones is used:

1. Acute and chronic bronchitis (at the stage of exacerbation).
2. Pneumonia caused by various pathogenic microorganisms.
3. Inflammation of the middle ear, sinuses, throat, etc.

Contraindications

Like most drugs, Ciprofloxacin has its own contraindications. In what situations this representative of classical fluoroquinolones cannot be used in the treatment of respiratory diseases and ENT pathology:

• Allergic reaction to Ciprofloxacin.
• Pseudomembranous colitis.
• Childhood and adolescence (until the end of the formation of the skeletal system). The exception is children with pulmonary cystic fibrosis who have developed infectious complications.
• Pulmonary anthrax.

In addition, patients with the following disorders and pathological conditions have restrictions on the use of Ciprofloxacin:

• Progressive atherosclerotic lesions of the blood vessels of the brain.
• Severe cerebral circulation disorders.
• Various heart diseases (arrhythmia, heart attack, etc.).
• Decreased levels of potassium and / or magnesium in the blood (electrolyte imbalance).
• Depressive state.
• Epileptic seizures.
• Severe central nervous system disorders (eg, stroke).
• Myasthenia gravis.
• Serious malfunction of the kidneys and / or liver.
• Advanced age.

Side effects

According to clinical practice, adverse reactions in the prevailing majority of patients taking fluoroquinolones are infrequent. Let's list the undesirable effects that occur in about 1 in 1000 patients taking Ciprofloxacin:

• Dyspeptic disorders (vomiting, pain in the abdomen, diarrhea, etc.)
• Decreased appetite.
• Feeling of heartbeat.
• Headache.
• Dizziness.
• Recurrent sleep problems.
• Changes in the main indicators of blood.
• Weakness, fatigue.
• Allergic reaction.
• Various skin rashes.
• Painful sensations in muscles and joints.
• Functional disorders of the kidneys and liver.

Do not buy Levofloxacin or Ciprofloxacin without first talking to your healthcare professional.

special instructions

With extreme caution, Ciprofloxacin is prescribed to patients who are already taking medications that lead to an extension of the QT interval:

1. Antiarrhythmic drugs.
2. Antibiotics from the macrolide group.
3. Tricyclic antidepressants.
4. Antipsychotics.

Clinical observations show that Ciprofloxacin enhances the effect of hypoglycemic drugs. With their simultaneous use, careful monitoring of blood glucose should be carried out. It is recorded that drugs that reduce acidity in the gastrointestinal tract (antacids), and containing aluminum and magnesium, reduce the absorption of fluoroquinolones from the digestive tract. The interval between the use of an antacid and an antibacterial drug should be at least 120 minutes. I would also like to note that milk and dairy products can affect the absorption of Ciprofloxacin.

In case of an overdose of the drug, the development of headache, dizziness, weakness, convulsive attacks, dyspeptic disorders, functional disorders of the kidneys and liver is possible. There is no specific antidote. The stomach is washed, activated charcoal is given. If necessary, symptomatic therapy is prescribed. Closely monitor the patient's condition until complete recovery.

Levofloxacin

Levofloxacin belongs to the third generation fluoroquinolones. Possesses high activity against gram-negative bacteria, pneumococci and atypical pathogens of respiratory infections. Most pathogens that show resistance (resistance) to the "classic" second-generation fluoroquinolones may be susceptible to more modern drugs such as Levofloxacin.

Food intake does not affect the absorption of Ciprofloxacin or Levofloxacin. Modern fluoroquinolones can be taken either before or after meals.

Indications

Levofloxacin is a broad-spectrum antibacterial drug. It is actively used for the following diseases of the respiratory system and ENT organs:

• Acute or chronic inflammation of the bronchi (at the stage of exacerbation).
• Inflammation of the paranasal sinuses (sinusitis, sinusitis, etc.).
• Infectious and inflammatory processes in the ear, throat.
• Pneumonia.
• Infectious complications of cystic fibrosis.

Contraindications

Despite the fact that Levofloxacin belongs to the new generation of fluoroquinolones, this drug can not be prescribed in all cases. What are the contraindications to the use of Levofloxacin:

• Allergic reaction to the drug or its analogues from the fluoroquinolone group.
• Serious kidney problems.
• Epileptic seizures.
• Tendon damage associated with previous fluoroquinolone therapy.
• Children and adolescents.
• Periods of childbearing and breastfeeding.

Levofloxacin should be prescribed with extreme caution in elderly patients.

Side effects

As a rule, all adverse reactions are classified according to the severity and frequency of occurrence. Let's list the main undesirable effects from taking Levofloxacin that may occur:

• Problems with the functioning of the gastrointestinal tract (nausea, vomiting, diarrhea, etc.).
• Headache.
• Dizziness.
• Allergic reactions (skin rash, itching, etc.).
• The level of essential liver enzymes rises.
• Drowsiness.
• Weakness.
• Pain in muscles and joints.
• Tendon damage (inflammation, tears, etc.).

Self-administration of Levofloxacin or Ciprofloxacin without the permission of the attending physician can have serious consequences.

special instructions

Since the likelihood of joint damage is high, Levofloxacin is not prescribed in childhood and adolescence (up to 18 years), with the exception of extremely severe cases. When using antibacterial drugs for the treatment of elderly patients, it should be borne in mind that this category of patients may have impaired renal function, which is a contraindication for prescribing fluoroquinolones.

During therapy with Levofloxacin, patients who have previously suffered a stroke or severe traumatic brain injury may develop epileptic seizures (convulsions). If you suspect the presence of pseudomembranous colitis, you must immediately stop taking Levofloxacin and prescribe the optimal course of therapy. In such situations, it is strongly discouraged to use drugs that inhibit intestinal motility.

Although rare, there may be cases of tendon inflammation (tendonitis) when using Levofloxacin. Older patients are more prone to this kind of adverse reactions. Concomitant use of glucocorticosteroids significantly increases the risk of tendon ruptures. If you suspect a tendon lesion (inflammation, ruptures, etc.), fluoroquinolone therapy is discontinued.

In case of an overdose of this drug, symptomatic therapy should be carried out. The use of dialysis in such cases is ineffective. There is no specific antidote.

During therapy with Levofloxacin, it is not recommended to engage in activities that require increased concentration of attention and a quick reaction (for example, driving). In addition, due to the risk of developing photosensitization, refrain from excessive exposure of the skin to ultraviolet rays.

Which drug should you choose?

How to determine which is better than Levofloxacin or Ciprofloxacin? Of course, only an experienced specialist can make the best choice. Nevertheless, when choosing a drug, it is necessary to rely on 3 main aspects:

A good drug is one that is not only effective, but also less toxic and available. In terms of effectiveness, Levofloxacin has its advantages over Ciprofloxacin. Along with the preserved activity against gram-negative pathogenic microorganisms, Levofloxacin has a more pronounced antibacterial effect against pneumococci and atypical pathogens. Nevertheless, it is inferior to Ciprofloxacin in activity against the pathogen Pseudomonas (P.) aeruginosa. It has been noted that pathogens that are resistant to Ciprofloxacin may be sensitive to Levofloxacin.

The type of pathogen and its sensitivity to antibacterial agents are decisive when choosing the optimal fluoroquinolone (in particular, Ciprofloxacin or Lefovloxacin).

Both drugs are well absorbed in the intestine when taken orally. Food practically does not affect the absorption process, with the exception of milk and dairy products. They are convenient to use because they can be prescribed 1-2 times a day. Regardless of whether you take Ciprofloxacin or Levofloxacin, in rare cases, unwanted side reactions may develop. As a rule, dyspeptic disorders (nausea, vomiting, etc.) are noted. Some patients taking second or third generation fluoroquinolones complain of headache, dizziness, weakness, increased fatigue, and sleep disturbance.

In elderly patients, especially with glucorticosteroid therapy, tendon ruptures are possible. Due to the risk of developing joint lesions, fluoroquinolones are limited in use during periods of gestation and breastfeeding, as well as during childhood.

Currently, for most patients, the price aspect is of paramount importance. A package of Ciprofloxacin tablets costs about 40 rubles. Depending on the dosage of the drug (250 or 500 mg), the price may fluctuate, but not significantly. More modern Levofloxacin will cost you an average of 200-300 rubles. The price will depend on the manufacturer.

At the same time, the final decision as to which is best for the patient, Ciprofloxacin or Levofloxacin, is made exclusively by the attending physician.

Antibiotic Ciprofloxacin: description, indications for use and medicinal properties of the drug

The group of fluoroquinolones, to which the antibiotic Ciprofloxacin belongs, appeared relatively recently. The first drug of this type began to be used only in the 1980s. Previously, antibacterial agents of this class were prescribed only for urinary tract infections. But now, due to their broad antimicrobial activity, fluoroquinolones, including the antibiotic Ciprofloxacin, are prescribed for bacterial pathologies that are difficult to treat, or with an undetected pathogen.

The mechanism of the bactericidal action of this drug is based on the penetration of the pathogenic microorganism through the cell membrane and the effect on the reproduction processes.

Fluoroquinolones inhibit the synthesis of bacterial enzymes that determine the twisting of a DNA strand around nuclear RNA; these are type I topoisomerase in gram-negative bacteria and class IV topoisomerase in gram-positive bacteria.

The antibiotic Ciprofloxacin is active against a wide range of bacteria resistant to the action of most antimicrobial drugs (Amoxicillin and its more effective analogue Amoxiclav, Doxycycline, Tetracycline, Cefpodoxime and others).

As indicated in the instructions for use, such bacterial strains are sensitive to the action of Ciprofloxacin:

• golden and saprophytic staphylococcus;
• the causative agent of anthrax;
• streptococcus;
• legionella;
• meningococcus;
• yersinia;
• gonococcus;
• haemophilus influenzae;
• moraxella.

Escherichia coli, enterococci, pneumococci and some strains of proteus are moderately sensitive. Resistant to the antibiotic Ciprofloxacin of mycoplasma and ureaplasma, listeria and other, infrequently found bacteria.

The drug belongs to the second generation fluoroquinolones, while its analogue of the same group, the no less common Levofloxacin, belongs to the third generation and is used more for the treatment of diseases of the respiratory tract.

The advantage of the antibiotic Ciprofloxacin is a wide range of dosage forms. So, for the treatment of bacterial eye infections to reduce the risk of systemic side effects, the drug is prescribed in the form of eye drops. In severe diseases, injections of Ciprofloxacin are needed, or rather, infusions, the standard dosage is 100 mg - 200 mg / 100 ml. After the patient's condition is normalized, the patient is transferred to tablets (they are available with an active ingredient concentration of 250 and 500 mg). Accordingly, the price of the drug is also different.

The main ingredient of the drug is ciprofloxacin, the presence of excipients depends on the specific form of antibiotic release. In a solution for infusion, it is purified water and sodium chloride, in eye drops - various solvents and stabilizers, in tablets - talc, silicon dioxide, cellulose.

The antibiotic Ciprofloxacin is prescribed to children from 5 years of age and adults to treat the following diseases:

• lesions of the lower respiratory tract, including pneumonia caused by flora sensitive to fluoroquinolones;
• ENT infections - organs, including sore throat, otitis media, sinusitis;
• diseases of the genitourinary system, for example, cystitis, pyelonephritis, urethritis, gonorrhea, bacterial prostatitis, adnexitis;
• various intestinal infections (shigellosis, salmonellosis, typhoid fever, cholera, enteritis, colitis);
• sepsis, peritonitis;
• infections affecting the skin, soft tissues, bones and cartilage, bacterial complications after burns;
• anthrax;
• brucellosis;
• yersiniosis;
• borreliosis;
• tuberculosis (as part of complex therapy);
• specific prophylaxis of bacterial infections in immunocompromised patients with HIV or AIDS, or the use of cytostatics.

In the form of eye drops, the antibiotic Ciprofloxacin is prescribed for infections of the mucous membrane of the organs of vision. According to experts, no cases of the development of resistance of the bacterial flora to the action of the drug have been identified to date. But fluoroquinolones are considered unsafe drugs, so they are not considered first line drugs for the treatment of uncomplicated bacterial infections.

Ciprofloxacin intramuscularly and in the form of eye drops and tablets

When taken orally, the antibiotic is absorbed quickly enough, mainly these processes occur in the lower parts of the digestive tract. The maximum concentration is reached in an hour and a half after using the Ciprofloxacin tablet. The general bioavailability of the drug is high and is about 80% (the exact indicators of the concentration of the active ingredient in the body depend on the dose taken).

Only dairy products affect the absorption of the antibiotic, therefore, they are advised to be excluded from the diet during treatment. Otherwise, food intake somewhat slows down the assimilation of Ciprofloxacin, but the bioavailability indicators do not change.

The active component of the drug binds to plasma proteins only by 15-20%. Basically, the antibiotic is concentrated in the pelvic and abdominal organs, saliva, lymphoid tissue of the nasopharynx, lungs. Ciprofloxacin is also found in synovial fluid, bone and cartilage tissue.

The drug enters the spinal canal in small quantities, so it is practically not prescribed for lesions of the central nervous system. Approximately one third of the total dosage of Ciprofloxacin is metabolized in the liver, the rest is excreted by the kidneys in an unchanged form. The half-life is 3-4 hours.

The exact amount of medication prescribed, as well as the duration of treatment, depends on many factors. First of all, this is the patient's condition. The standard recommendation for using any antibacterial agent is to continue taking it for at least three days after the temperature has returned to normal. This applies to both oral forms and the use of Ciprofloxacin intramuscularly.

For adults, the dosage of the drug is 500 mg twice a day, regardless of food intake.

The annotation to the drug indicates the average duration of therapy:

• for diseases of the respiratory tract - up to two weeks;
• with lesions of the digestive system from 2 to 7 days, depending on the severity of the clinical picture and the causative agent of the infection;
• with diseases of the genitourinary system, prostatitis therapy lasts the longest - up to 28 days, to eliminate gonorrhea, a sufficient single dose, with cystitis and pyelonephritis, treatment continues up to 14 days;
• with infections of the skin and soft tissues - an average of two weeks;
• with bacterial lesions of bones and joints, the duration of therapy is determined by the doctor and can last up to 3 months.

Important

A severe course of infection is an indication for increasing the daily dosage for an adult to 1.5 g.

Important

The maximum daily dosage of the drug in childhood should not exceed 1.5 g per day.

Ciprofloxacin is not administered intramuscularly. The antibiotic solution is administered intravenously only. Moreover, its action develops much faster than that of tablets. The maximum concentration in blood plasma is reached after 30 minutes. The bioavailability of Ciprofloxacin solution is also higher. With intravenous injections, it is almost completely excreted unchanged by the kidneys within 3-5 hours.

Unlike tablets, for many uncomplicated bacterial diseases, a single infusion of Ciprofloxacin is sufficient. In this case, the daily dosage for adults is 200 mg or two injections during the day. For a child, the required amount of the drug is determined by the proportion of 7.5-10 mg / kg per day (but not more than 800 mg per day).

The ready-made solution for infusion is not produced in small ampoules, but in 100 ml vials, the concentration of the active substance is 100 or 200 mg. The drug can be used immediately, it does not require further dilution.

Eye drops with ciprofloxacin are intended for the treatment of various infectious eye lesions (conjunctivitis, blepharitis, keratosis and ulcers) caused by sensitive flora. Also, the drug is prescribed to prevent postoperative and post-traumatic complications.

The total volume of the bottle with drops is 5 ml, while 1 ml of the solution contains 3 mg of active ciprofloxacin. With moderately severe symptoms of the disease and for preventive purposes, the drug is prescribed 1-2 drops in each eye every four hours. For complicated infections, the frequency of use is increased - the procedure is repeated every two hours.

Ofloxacin or Ciprofloxacin: which is better, other analogues of the drug, restrictions on use

The use of the drug is categorically contraindicated during pregnancy and lactation. In addition, Ciprofloxacin affects the formation of the structure of bone and cartilage tissue, therefore, it is prescribed for children under 18 only for strict medical reasons.

Also, contraindications to taking the drug is an increased sensitivity not only to Ciprofloxacin, but also to other drugs from the group of fluoroquinolones.

The use of an antibiotic should be carried out under strict medical supervision in case of impaired renal excretory function, severe diseases of the central nervous system. If the use of Ciprofloxacin is started after surgery under general anesthesia, monitor the pulse and blood pressure.

Unlike other, safer antibacterial drugs from the class, for example, penicillins, the risk of adverse reactions during therapy with Ciprofloxacin is high.

The patient is warned of the following possible side effects:

• impaired clarity of vision and color perception;
• the occurrence of a secondary fungal infection;
• digestive disorders, accompanied by vomiting, nausea, heartburn, diarrhea, inflammatory lesions of the intestinal mucosa are extremely rare;
• dizziness, headache, sleep disorders, anxiety and other disorders of the psychoemotional state, sometimes convulsions;
• hearing impairment;
• acceleration of heart rate, arrhythmias against the background of low blood pressure;
• shortness of breath, impaired lung function;
• disorders of the hematopoietic system;
• deterioration in kidney and liver function;
• rashes, itching, swelling.

Ciprofloxacin is found in many drugs.

So, instead of this medicine, the doctor can prescribe the following medicines to the patient:

• Tsiprolet (solution for infusion, eye drops, tablets of 250 and 500 mg);
• Betacyprol (eye drops);
• Quintor (tablets and infusion solution);
• Tsiprinol (in addition to solution for injection and conventional tablets, there are also capsules with prolonged action);
• Cyprodox (tablets with a dosage of 250, 500 and 750 mg).

If we talk about analogues of this antibiotic, we should also mention other antibacterial agents from the group of fluoroquinolones. So, patients often ask a doctor, Ofloxacin or Ciprofloxacin, which is better? Or maybe replace with more modern Norfloxacin or Moxifloxacin?

The fact is that the indications for use for all of the listed funds are the same. Like Ciprofloxacin, they work well against the main pathogens of cystitis, pneumonia, prostatitis and other infections. But doctors emphasize that the "older" the generation of fluoroquinolone, the greater its activity against pathogenic flora. But at the same time, the risk of severe adverse reactions also increases.

Therefore, the question of Ofloxacin or Ciprofloxacin, which is better, is not entirely correct. An antibiotic should be prescribed solely on the basis of the identified pathogen and the general condition of the patient. In other words, if the doctor sees that Ciprofloxacin will completely cope with, for example, pyelonephritis, then there is no need to prescribe the stronger, but less safe Norfloxacin or Lomefloxacin.

As for the cost of an antibiotic, it largely depends on the manufacturer and the purity of the substance used for the production of the drug. So, domestic eye drops with Ciprofloxacin cost from 20 to 30 rubles. A pack of 10 tablets with a dosage of 500 mg will cost one ruble. The cost of one bottle of solution for infusion fluctuates within rubles.

“Ciprofloxacin has been prescribed to treat kidney inflammation. Before that, other, weaker antibiotics were prescribed, but only this drug helped. The first few days I had to endure droppers, then transferred to pills. I was also pleased with the low price of the medicine. "

Given the high risk of dangerous adverse reactions, only a doctor should decide whether Levofloxacin or Ciprofloxacin is better. The drugs are quite toxic, therefore, it is additionally recommended to take biochemical and clinical blood and urine tests to prevent possible complications of therapy.

Specialty: Otorhinolaryngologist Work experience: 29 years

Specialty: Physician-audiologist Work experience: 7 years

Levofloxacin: Analogs, Review of Essential Medicines Similar to Levofloxacin

According to the latest medical statistics, the spread of prostatitis and its forms has recently begun to increase. The reasons for this situation can be called a lot of factors, among which, the main place is occupied by a man's unsatisfactory attitude to his health, poor ecology, poor-quality food, etc.

Therefore, it is not surprising how seriously pharmacologists have to work in order to offer patients the newest and most effective drugs for the treatment of prostatitis. Among them, there is also Levofloxacin - the latest generation antibiotic with a wide spectrum of action.

This type of drug, like Amoxiclav, belongs to antibiotics with a wide spectrum of action and is ideal for the systemic treatment of various diseases, including prostatitis (acute, chronic, bacterial).

The release form of the drug is tablets or injection solutions. Any form of the drug is quickly absorbed into the bloodstream, affects the body at the cellular level, and the targeted action of the drug allows you to effectively kill entire colonies of harmful microorganisms. For people suffering from infectious and bacterial diseases, it will be much cheaper to purchase such a medication than to buy other synonyms and antibiotic substitutes, which also have side effects and contraindications.

Levofloxacin analogs have the following properties:

• They have a wide and active range of effects on the body.
• They are able to quickly penetrate the tissues of the prostate.
• They show a high degree of activity and directed action.

Before taking the medicine, you should read all the information that the instructions for taking the medicine offer you. Like any other antibiotic, domestic or imported, Levofloxacin can cause side effects and individual intolerance.

Today you can choose not only Levofloxacin, analogues of this drug, similar in composition, action and form of release, are presented on the market in large quantities.

Tavanic is the same effective antibiotic that is prescribed for a variety of diseases. It is characterized by a high degree of drug activity and impact on groups of harmful microorganisms, its use allows you to obtain positive treatment results in the shortest possible time for therapy. The price of the product depends on the form of release: tablets can be bought from 600 rubles, solution for injections, it will cost you 1620 rubles.

Ciprofloxacin is an active antibiotic with a broad spectrum of action. It is used to treat infectious diseases of internal organs and tissues, in particular, the genitourinary system. The drug is produced in various forms, for example, these are eye drops, suspensions and solutions for injections, tablets and capsules. The cost of the antibiotic is low, from 18 rubles, and any pharmacy can offer you this drug.

Along with the above-mentioned Russian analogues, there are also foreign analogues of Levofloxacin on the market that can defeat any infectious disease.

Eleflox, produced by an Indian pharmaceutical company, is actively used to treat various forms of prostatitis, inhibits the activity of harmful microorganisms. It is used in systemic treatment, in which the disease quickly responds to therapy.

Glevo is a product of Indian pharmacology, with a wide spectrum of action, excellent for the treatment of all forms of prostatitis.

Levofloxacin belongs to the group of fluoroquinols. The same group with the active substance levofloxacin includes:

All antibiotics in this group are very effective in the treatment of prostatitis. Therefore, your choice of a drug can only be influenced by the presence of an individual intolerance to the components of one of them, the severity of the disease, at which it is necessary to apply complex treatment, in which not all antibiotics may be compatible with other drugs. All drugs have detailed instructions, after reading which, you will find out what side effect can be expected, what contraindication in your case may affect the choice of the remedy.

Tavanic or Levofloxacin which is better?

As we have already noted, both of these drugs belong to the group of fluoroquinols, with an active ingredient - levofloxacin, which quickly enters the bloodstream, then it is taken by the plasma and distributed to all tissues of the body.

The drug Levofloxacin has an active effect on various tissue areas affected by harmful microorganisms, and it acts directly at the cellular level, which speeds up treatment and gives positive results. With prostatitis, different groups of bacteria can be present in the body that affect the organ and cause the disease: anaerobic gram-positive and gram-negative, simple microorganisms and chlamydia. With all these "pests" the drug fights very effectively.

Tavanik is a latest generation antibiotic with high rates of effectiveness in the treatment of diseases of various internal organs, bone tissue.

The active substance in the drug is levofloxacin, auxiliary - crospovidone, cellulose, titanium dioxide, macrogol 8000, iron oxide red and yellow. When taking the drug, its concentration in the blood lasts for a rather long period.

An antibacterial drug gives the fastest and most positive results in the treatment of various forms of prostatitis, ranging from mild to chronic, as it affects tissue cells, their membranes and walls. It is especially effective in complex treatment, because its active and active component - levofloxacin, interacts well with other drugs.

If we compare Tavanic or Levofloxacin, which is better, then the first drug has fewer side effects and has a faster action and the spectrum of its action is much wider.

Comparing the cost of drugs, it can be noted that you can buy Levofloxacin at a price of 77 rubles, and Tavanik - from 590 rubles.

Most often, when the doctor prescribed a course of treatment with this drug, the patient is prescribed 2 doses.

The average daily dose of the drug at each dose ranges from 500 ml to 1 g, depending on the form of the disease in which the prostate gland is located. If injections are prescribed, then the daily dose of liquid is from 250 to 500 ml, depending on the severity of the disease. The medicine is taken regardless of food intake. the mucous membrane quickly absorbs the substances of the drug.

In milder forms of prostatitis, as well as in diseases that affect the bronchi, the course of treatment can be from 14 to 28 days. In this case, the daily dose ranges from 500 ml to 1 g.

To decide whether Tavanic or Levofloxacin is better, your doctor will help you, who will select the optimal antimicrobial drug for effective therapy.

Levofloxacin or Ciprofloxacin: Comparative Evaluation of Drugs

The medicine has a wide spectrum of action, inhibits the vital activity of various microorganisms, quickly enters the bloodstream, is distributed throughout the tissues of the body, and any infection is amenable to such therapy.

The doctor prescribes the drug, who calculates the daily dose of the drug.

The course of treatment can be from 1 to 4 weeks, depending on the degree of the disease.

If we consider Levofloxacin and Ciprofloxacin, the difference is that the former is more effective, it can interact with other drugs, while Ciprofloxacin, under the influence of other drugs, can reduce its concentration and activity, which delays the course of treatment.

Both drugs, Levofloxacin and Ciprofloxacin, are antibiotics that should only be taken on the advice of a physician, who considers each case on a case-by-case basis.

The main difference between the two antibiotics is the active substance: in the first drug it is levofloxacin, and in the second it is ofloxacin. Under the action of Ofloxacin, not all groups of bacteria can be destroyed, since microorganisms have different degrees of sensitivity to ofloxacin, therefore, prostatitis therapy may be different due to the causes of the disease and the effectiveness of treatment may also differ.

Levofloxacin Astrafarm: description of the drug and its distinctive features

Distinctive features from Levofloxacin

Levofloxacin Astrapharm is able to inhibit the activity of gram-positive and gram-negative microbes, while Levofloxacin acts on all groups of bacteria.

Most often, Levofloxacin Astrapharm is used to effectively treat chronic bacterial prostatitis.

During therapy with Levofloxacin, positive dynamics is observed already in the middle of treatment, and this happens regardless of the form of the disease.

If we talk about Levofloxacin Astrafarm blister, then it is more effective in the treatment of mild and moderate forms of prostatitis.

Regardless of what choice you make in the treatment of prostatitis, you must remember that only systemic, well-chosen treatment can give positive dynamics and results.

Specialty: Urologist Work experience: 21 years

Specialty: Urologist-andrologist Work experience: 26 years