Famotidine belongs to the blockers of histamine H 2 receptors. The drug is able to have an antiulcer effect.
Description of the medication
Famotidine, the indications for which are listed in detail in the instructions, is produced in the form of tablets. The active ingredient of the drug is a substance with the same name. Famotidine is contained in tablets at a concentration of 20 or 40 mg. The medicine is in blisters of 10 pieces.
The tablets are round in shape. They are colored brown. The surface of the tablets is smooth, biconvex.
Another form of release of the drug is a lyophilizate intended for the manufacture of a solution for intravenous administration.
The drug, made in the form of a lyophilisate, is colored white or yellowish.
The active ingredient of the drug is famotidine. The composition of the drug also contains such auxiliary ingredients as aspartic acid, mannitol.
Therapeutic impact
The drug helps to increase the pH of gastric juice. Famotidine helps stop gastric bleeding. When taken orally, the drug enters the general circulation approximately 60 minutes after ingestion.
The maximum concentration of the active substance of the drug in plasma is observed after approximately 3 hours.
The tool has a pronounced wound-healing and protective effect.
When using the drug, the process of regeneration of the affected gastric mucosa is activated. As a result, pain is reduced. Famotidine slows down the rate of hydrochloric acid production.
Indications for use
Famotidine is prescribed for the treatment of gastric ulcer, erosive gastroduodenitis, duodenal ulcer. It is used for systemic mastocytosis, polyendocrine adenomatosis. The medicine is also effective for heavy gastric bleeding that occurs after surgical procedures.
The instruction prescribes the use of the medication and to prevent the occurrence of ulcers in the area of the gastric mucosa. They can form on the background of prolonged use of non-steroidal anti-inflammatory drugs. Famotidine is also used to prevent the development of aspiration pneumonitis.
Contraindications for use
It is worth listing the main contraindications to the use of the drug. The drug must not be used for cirrhosis of the liver, accompanied by portosystemic encephalopathy. It is contraindicated in severe renal failure.
Famotidine is not recommended for use in children under 12 years of age. It is not prescribed for hypersensitivity to the components of the drug. One of the contraindications to the use of the drug is a severe form of liver failure.
The drug is not prescribed to pregnant women. The effect of the drug on the fetus has not been studied in detail. The use of the drug should be abandoned during breastfeeding.
Adverse reactions
When using the drug, side effects may occur that require discontinuation of the drug or correction of the recommended dose. From the side of the digestive tract, the following complications are observed:
- the occurrence of dryness in the oral cavity;
- the appearance of signs of acute pancreatitis;
- flatulence;
- the occurrence of pain in the abdomen;
- heartburn.
From the side of the nervous system, there are side effects such as worsening sleep, the occurrence of hallucinations. When taking anti-ulcer tablets, there may be a clouding of consciousness. In some cases, when taking the medicine, dizziness appears.
When using the medication, tachycardia, bradycardia can be observed.
The drug also affects the state of the hematopoietic system. After using the medication, thrombocytopenia can be diagnosed. Side effects from the genitourinary system are presented below:
After using the medicine, muscle pain may occur. There is a possibility of allergic reactions during treatment with Famotidine. They consist in the occurrence of bronchospasm, irritation on the skin.
Instructions for using tablets and solution
To prevent the occurrence of stomach ulcers in the presence of gastritis in a patient, take 0.02 g of the drug once a day. It should be drunk shortly before bedtime. With reflux esophagitis, 0.02 g of the drug is prescribed twice a day.
Medication analogues
The analogue of the drug is Kvamatel. The main features of the drug are given in the corresponding table. In the treatment of gastric ulcer, De-nol, Ranitidine-Ferein are also used.
| A drug | Active substance | Manufacturer | Price |
| Kvamatel | Famotidine is the active ingredient in Kvamatel. The drug is available in the form of tablets, powder, used for injection. Indications for the appointment of Kvamatel are: pancreatitis, gastric ulcer, erosive gastroduodenitis. Tablets are taken regardless of food intake. In the presence of food in the stomach, the bioavailability of Kvamatel does not change. | OJSC "Gedeon Richter" | Approximately 120-150 rubles |
| De-nol | The active substance of De-nol is bismuth tripotassium dicitrate. The composition of the tablets additionally contains the following components:
| ASTELLAS PHARMA EUROPE B.V. | 300 rubles per package |
| Ranitidine-Ferein | The active ingredient is ranitidine hydrochloride. Ranitidine-Ferein also contains excipients:
| Company "Bryntsalov-A" | Approximately 50 rubles |
De-nol has an antiulcer, astringent, anti-inflammatory effect. Ranitidine-Ferein has a similar effect. It prevents the occurrence of ulcers when taking non-steroidal anti-inflammatory drugs.
Overdose of funds
With an overdose of Famotidine, the patient needs hemodialysis. After carrying out this procedure, the use of intestinal sorbents and other medicines is indicated. Symptomatic treatment is aimed at eliminating the complications that have arisen with an overdose of Famotidine.
Famotidine and drug analogues should not be taken in the presence of a benign tumor of the stomach - carcinoma. The drug masks the characteristic symptoms of the disease. As a result, the course of the disease is complicated.
The medicine is canceled gradually. This is necessary to prevent a sharp increase in the level of acidity of gastric juice. In addition, when treating with Famotidine, a strict diet is followed. Foods that have an irritating effect on the affected gastric mucosa are excluded from the diet.
Features of drug interaction
When using tablets, the features of their drug interactions with other drugs should be taken into account. The optimal interval between the use of Ketoconazole and Famotidine is 2 hours. The drug is not recommended to be taken simultaneously with drugs that depress the work of the bone marrow. In this case, the risk of exacerbation of neutropenia increases.
With the simultaneous use of the drug with Phenazone, Phenytoin, Lidocaine, the metabolism of the latter may worsen. When using the drug in combination with antacids, the rate of adsorption of Famotidine slows down. This circumstance must also be taken into account.
Omeprazole or Famotidine: which is better?
Both drugs help reduce the concentration of hydrochloric acid in the stomach. But Omeprazole with a similar problem is more effective. Visible relief comes about half an hour after taking the pill.
The action of Famotidine is rather slow: it becomes noticeable after 1-2 hours. helps to suppress the production of hydrochloric acid. And Famotidine only temporarily stops its release. It is strictly forbidden to drink both medicines at the same time. Otherwise, the level of acidity of the stomach will drop sharply.
Terms of storage and sale
A doctor's prescription is required to purchase medication at a pharmacy. Famotidine is best stored at a temperature not exceeding 25 degrees, in a place protected from direct sunlight. The duration of the shelf life of tablets is 3 years from the date of their release.
The approximate cost of a package of medicine (40 mg) is 100 rubles. How much Famotidine costs depends on the number of tablets in the package, the concentration of the active substance, the manufacturer. It is worth considering the pricing policy of the pharmacy.
Main conclusions
In conclusion, it should be noted that the drug is not recommended to drink during pregnancy and breastfeeding. In addition, treatment is stopped if side effects occur. When using the drug, you may experience:
Famotidine has effective analogues. One of these medicines is Kvamatel. It is a blocker of H 2 -histamine receptors.
Instructions for use:
Famotidine belongs to the group of histamine H2 receptor antagonists and is intended for the treatment of reflux esophagitis and peptic ulcer.
pharmachologic effect
Famotidine inhibits the release (secretion) of hydrochloric acid. In addition, this drug reduces the activity of the enzyme that breaks down proteins, pepsin. According to reviews, Famotidine begins to have a therapeutic effect already 45-60 minutes after taking the initial dose. The duration of action of the drug is determined by the dose taken and ranges from 12 hours to a day.
Indications
- Reflux esophagitis - inflammation of the mucous membrane of the esophagus, caused by the ingestion of acidic gastric contents;
- Zollinger-Ellison syndrome is a pathological condition in which there is a combination of a gastric ulcer and a benign neoplasm of the pancreas;
- Peptic ulcer of the stomach and duodenum.
Famotidine is also indicated for the prevention of the development of peptic ulcer in patients who have been treated for systemic diseases for a long time using non-steroidal anti-inflammatory drugs (NSAIDs) or glucocorticosteroids.
Application of Famotidine
The dosage of the drug is selected by the doctor individually. With an exacerbation of peptic ulcer, it is usually prescribed once a day for 0.04 g. In some cases, the use of Famotidine twice a day for 0.02 g is justified. The duration of the course of treatment should be from 4 to 8 weeks. After the ulcer heals, Famotidine is gradually stopped. To prevent subsequent exacerbations, the drug is taken at bedtime at a dose of 0.02 g.
With Zollinger-Ellison syndrome and reflux esophagitis, Famotidine is prescribed four times a day for 0.02 g.
According to the instructions, Famotidine can also be used to treat patients with impaired renal function. In this case, the daily dose should be reduced in accordance with the values of creatinine clearance.
According to reviews, Famotidine is also effective with increased secretion of hydrochloric acid. In this case, it is prescribed once a day, preferably at bedtime at a dose of 0.02 - 0.04 g.
Side effects
According to the instructions, Famotidine can lead to the development of the following side effects:
- Dyspeptic phenomena;
- Increased activity of liver enzymes (transaminases);
- cholestatic jaundice;
- Dizziness and/or headache;
- taste disturbances;
- Decreased appetite;
- Noise in ears;
- mental disorders;
- Arthralgia and myalgia;
- Increase in body temperature;
- Skin rash;
- Violations of the picture of peripheral blood (leukopenia, thrombocytopenia or agranulocytosis). According to reviews, Famotidine in very rare cases can lead to the development of pancytopenia - a sharp decrease in all blood cells;
- Bronchospasm;
- Acne;
- Alopecia areata.
Famotidine contraindications
The use of Famotidine is contraindicated during pregnancy and lactation, as well as if the patient has an individual intolerance to this drug.
special instructions
According to the instructions for Famotidine, it is allowed to prescribe the drug in combination with non-absorbable antacids (drugs that reduce the acidity of gastric juice). However, it is necessary that between taking these drugs there should be an interval of at least two hours.
Release form Famotidine
Famotidine is available in the form of tablets containing 0.02 g of the active substance in a package of 20 pieces. Also, the drug is produced in a larger dosage - 0.04 g each. In this case, 10 tablets are in one package.
Famotidine's analogs
The drug Famotidine has many analogues: Famocid, Famosan, Famonit, Famodin, Famogard, Ulceran, Ulfamid, Topcid, Pepsidin, Nevopharm, Lecedil, Kvamatel, Gastrosidin, Gastrogen, Blockacid, Acipen, Antodin, etc.
Despite the fact that pharmacies provide a wide range of Famotidine analogues, it is advisable to use exactly the drug that is prescribed to you by your doctor.
Storage conditions
Famotidine is on Schedule B and is not intended for treatment without a doctor's prescription. The drug is stored in a dry, dark place, out of the reach of children.
Famotidine is an antiulcer drug that, showing a persistent antagonistic dislike for histamine, blocks the “named” receptors of this mediator. By inactivating H2-histamine receptors of glandulocytes, it significantly reduces the secretion of hydrochloric acid caused by various stimuli. The action of famotidine is dose-dependent, i.e. the greater the concentration of the active substance in the blood plasma, the more basal and stimulated (caused by histamine, gastrin and acetylcholine) secretion of hydrochloric acid is suppressed. Simultaneously with an increase in pH, the drug reduces the activity of the digestive enzyme pepsin. After oral administration, the pharmacological effect of famotidine begins to develop after 1 hour and reaches its peak after 3 hours. The activity of the drug, as already mentioned, is strongly dependent on the dose and after a single dose can be maintained in the time range between 12 and 24 hours. Famotidine tablets are rapidly absorbed from the digestive tract. The bioavailability of the drug depends little on food intake, but suffers when taking antacids.
Famotidine is available exclusively in tablets. They should be taken without chewing, in doses prescribed by the attending physician, depending on the indications.
An ulcer of the stomach and duodenum in the acute phase requires a daily intake of 40 mg of the drug (you can take this dose for 1 or 2 times, in the first case - at night). In the absence of the desired effect, it is allowed to increase the dose to 80-160 mg. The duration of the therapeutic course is 1-2 months. With dyspeptic symptoms due to increased acidity of the stomach, a dose of 20 mg 1-2 times a day will be sufficient. In any case, the frequency of administration and dosage should be agreed with the gastroenterologist.
The disappearance of symptoms of gastric and duodenal ulcers should not cause immediate discontinuation of the drug: treatment should be continued for another 7-14 days, after which it is necessary to conduct an endoscopic examination for scarring of the ulcer. Before therapy with famotidine, it is recommended to verify the benign nature of gastric pain, because. an ulcer can "mask" a carcinoma of the stomach. Famotidine is characterized by the "rebound" syndrome (deterioration of the clinical picture after abrupt discontinuation of the drug). While on a course of treatment with famotidine, you should refrain from drinking drinks and foods that irritate the gastric mucosa.
Pharmacology
Blocker of H 2 -histamine receptors of the III generation. Suppresses basal and stimulated by histamine, gastrin and acetylcholine production of hydrochloric acid. Simultaneously with a decrease in the production of hydrochloric acid and an increase in pH, the activity of pepsin also decreases. Significantly does not change the concentration of gastrin in plasma. Weakly inhibits the cytochrome P450 oxidase system in the liver. After oral administration, the action begins after 1 hour, reaches a maximum within 3 hours. The duration of action of the drug in a single dose depends on the dose and ranges from 12 to 24 hours.
Pharmacokinetics
After oral administration, it is rapidly absorbed from the gastrointestinal tract. Cmax in plasma is achieved within 1-3.5 hours. The bioavailability of famotidine is 40-45%, changes slightly in the presence of food and decreases while taking antacids.
Communication with plasma proteins - 15-20%. Penetrates through the placental barrier and excreted in breast milk.
30-35% of famotidine is metabolized in the liver (with the formation of S-oxide).
Elimination mainly occurs through the kidneys, 27-40% of the drug is excreted in the urine unchanged. T 1 / 2 - 2.5-4 hours, in patients with creatinine clearance below 30 ml / min increases to 10-12 hours.
In patients with severe renal insufficiency (creatinine clearance below 10 ml / min), it increases up to 20 hours.
Release form
7 pcs. - cellular contour packings (1) - packs of cardboard.
7 pcs. - cellular contour packings (2) - packs of cardboard.
7 pcs. - cellular contour packings (3) - packs of cardboard.
7 pcs. - cellular contour packings (4) - packs of cardboard.
7 pcs. - cellular contour packings (10) - packs of cardboard.
10 pieces. - cellular contour packings (1) - packs of cardboard.
10 pieces. - cellular contour packings (2) - packs of cardboard.
10 pieces. - cellular contour packings (3) - packs of cardboard.
10 pieces. - cellular contour packings (4) - packs of cardboard.
10 pieces. - cellular contour packings (10) - packs of cardboard.
14 pcs. - cellular contour packings (1) - packs of cardboard.
14 pcs. - cellular contour packings (2) - packs of cardboard.
14 pcs. - cellular contour packings (3) - packs of cardboard.
14 pcs. - cellular contour packings (4) - packs of cardboard.
14 pcs. - cellular contour packings (10) - packs of cardboard.
20 pcs. - cellular contour packings (1) - packs of cardboard.
20 pcs. - cellular contour packings (2) - packs of cardboard.
20 pcs. - cellular contour packings (3) - packs of cardboard.
20 pcs. - cellular contour packings (4) - packs of cardboard.
20 pcs. - cellular contour packings (10) - packs of cardboard.
Dosage
Inside, without chewing, drinking plenty of water.
With peptic ulcer of the stomach and duodenum in the acute phase, symptomatic ulcers, erosive gastroduodenitis, 20 mg 2 times a day or 40 mg 1 time per day at night are usually prescribed. If necessary, the daily dose can be increased to 80-160 mg. The course of treatment is 4-8 weeks.
With dyspepsia associated with increased secretory function of the stomach, 20 mg is prescribed 1-2 times a day.
For the prevention of recurrence of peptic ulcers of the stomach and duodenum: 20 mg once at bedtime.
With reflux esophagitis - 20-40 mg 2 times a day for 6-12 weeks.
With Zollinger-Ellison syndrome, the dose of the drug and the duration of the course of treatment are set individually. The initial dose is usually 20 mg every 6 hours and may be increased to 160 mg every 6 hours.
For the prevention of aspiration of gastric juice during general anesthesia, 40 mg is prescribed in the evening and / or in the morning before surgery.
In renal failure, if CC is less than 30 ml / min or serum creatinine is more than 3 mg / 100 ml, the daily dose of the drug should be reduced to 20 mg.
To prevent recurrence of bleeding from the upper gastrointestinal tract - 20 mg 2 times a day for 3-4 weeks.
Overdose
Symptoms: vomiting, motor agitation, tremor, lowering blood pressure, tachycardia, collapse.
Treatment: gastric lavage, symptomatic therapy, hemodialysis.
Interaction
Due to an increase in the pH of the contents of the stomach, while taking it, the absorption of ketoconazole and itraconazole may decrease.
With simultaneous use with antacids, sucralfate, the intensity of famotidine absorption decreases, so the interval between taking these drugs should be at least 1-2 hours.
It inhibits the metabolism in the liver of phenazone, aminophenazone, diazepam, hexobarbital, propranolol, metoprolol, lidocaine, phenytoin, theophylline, indirect anticoagulants, glipizide, buformin, metronidazole, caffeine, "slow" calcium channel blockers, tricyclic antidepressants. Increases the absorption of amoxicillin and clavulanic acid.
Medicines that depress the bone marrow increase the risk of developing neutropenia.
Side effects
From the digestive system: dry mouth, nausea, vomiting, abdominal pain, loss of appetite. In some cases, an increase in the activity of transaminases in the blood plasma.
From the nervous system: headache, dizziness, tinnitus, transient mental disorders.
From the side of the cardiovascular system: rarely - arrhythmias.
On the part of the hematopoietic organs: rarely - leukopenia, thrombocytopenia, agranulocytosis, pancytopenia.
On the part of the reproductive system: with prolonged use of large doses - hyperprolactinemia, gynecomastia, amenorrhea, decreased libido, impotence.
From the senses: paresis of accommodation, blurred vision, ringing in the ears.
Allergic reactions: urticaria, pruritus, skin rash, bronchospasm are possible.
Other: fever, arthralgia, myalgia.
Indications
- treatment and prevention of recurrence of peptic ulcer of the stomach and duodenum;
- treatment and prevention of symptomatic gastric and duodenal ulcers (associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs), stress, postoperative ulcers);
- erosive gastroduodenitis;
- functional dyspepsia associated with increased secretory function of the stomach (including heartburn, sour belching);
- reflux esophagitis;
- Zollinger-Ellison syndrome;
- prevention of recurrence of bleeding from the upper gastrointestinal tract (GIT);
- prevention of aspiration of gastric juice during general anesthesia (Mendelssohn's syndrome).
Contraindications
- children under 12 years of age (due to lack of sufficient experience in the use of the drug);
- individual hypersensitivity to the components of the drug.
With caution: liver failure, liver cirrhosis with a history of portosystemic encephalopathy, renal failure, immunodeficiency, old age.
Application features
Use during pregnancy and lactation
Use during pregnancy is possible only if the potential benefit to the mother outweighs the risk to the fetus.
Penetrates into breast milk. During lactation, discontinue the use of the drug or stop breastfeeding.
Application for violations of liver function
With caution in liver failure.Application for violations of kidney function
With caution in renal failure.Use in children
Contraindicated in children under 12 years of age.special instructions
Symptoms of duodenal ulcer may disappear within 1-2 weeks, therapy should be continued until scarring is confirmed by endoscopic or x-ray data. May mask the symptoms associated with gastric carcinoma, therefore, before starting treatment, it is necessary to exclude the presence of a malignant neoplasm. Cancel gradually because of the risk of developing the "rebound" syndrome with abrupt cancellation.
With long-term treatment of debilitated patients, as well as stress, bacterial lesions of the stomach are possible, followed by the spread of infection. H2-histamine receptor blockers should be taken 2 hours after taking itraconazole or ketoconazole to avoid a significant decrease in their absorption. Counteracts the influence of pentagastrin and histamine on the acid-forming function of the stomach.
Suppresses the skin reaction to histamine, thus leading to false-negative results (it is recommended to stop using H2-histamine receptor blockers before performing diagnostic skin tests to detect an immediate type of allergic skin reaction).
During treatment, you should avoid eating foods, drinks and other drugs that can cause irritation of the gastric mucosa.
The effectiveness of the drug in inhibiting nocturnal acid secretion in the stomach may
decrease as a result of smoking.
Patients with burns may need to increase the dose of the drug due to increased clearance.
If a dose is missed, it must be taken as soon as possible; do not take if it is time for the next dose; do not double doses.
Influence on the ability to drive a car and other mechanisms
There are no data on the effect of the drug on the ability to drive vehicles or perform work that requires concentration and increased attention.
Content
To regulate the acidity of gastric juice in chronic stomach or duodenal ulcers, doctors prescribe the drug Famotidine (Famotidine). This medication belongs to the group of inhibitors (blockers) of histamine H2 receptors, characterized by targeted, local action in the body.
Composition and form of release
Famotidine is a round brown tablet with a biconvex smooth surface. The active ingredient is famotidine, in 1 pc. contained in a concentration of 20 or 40 mg. Tablets are packaged in blisters of 10 pcs. There are 2 or 3 blisters in a cardboard pack, instructions for use, which, among other things, describe the chemical composition:
Drug properties
Instructions for use Famotidine reports that the component of the same name inhibits the production of hydrochloric acid and the activity of pepsin (an enzyme that breaks down proteins), increases the pH of gastric juice, and reduces the production of HCl. The level of glycoproteins increases, due to which the formation of gastric mucus, the synthesis of prostaglandins, and the secretion of bicarbonate increase. This ensures a protective and wound-healing effect.
Famotidine in the hepatic system has little effect on the oxidase system of the cytochrome P450 enzyme. Other pharmacological properties of this antiulcer drug are reflected in the instructions for use:
- cessation of gastric bleeding;
- healing of the injured gastric mucosa;
- scarring of stress ulcers;
- strengthening the protective mechanisms of the mucous walls of the stomach;
- moderate reduction in pain.
When administered orally as a single dose, famotidine is rapidly absorbed from the gastrointestinal tract and enters the bloodstream in about 1 hour. After 3 hours reaches the maximum concentration in plasma. According to the instructions, the bioavailability index is 45-50%. The therapeutic effect is maintained for 12-24 hours, which depends on the stage of the pathological process. Metabolism occurs in the liver, and inactive metabolites are excreted by the kidneys - with urine.
Indications for use Famotidine
The indicated medication is prescribed, if necessary, to reduce the acidity of gastric juice and cure diseases associated with such a functional disorder. The instructions for use provide a complete list of medical indications:
- peptic ulcer of the duodenum and stomach;
- Zollinger-Ellison syndrome (formation of a gastrin-producing tumor in the pancreas);
- erosive gastroduodenitis (formation of erosions on the gastric mucosa);
- reflux esophagitis (an inflammatory process in the esophagus associated with the reuptake of gastric contents);
- stressful, symptomatic stomach ulcers;
- systemic mastocytosis (infiltration of monocytes in the stomach);
- prolonged signs of dyspepsia;
- polyendocrine adenomatosis (lesion of the gastric glands);
- complications after operations on the organs of the digestive tract, for example, heavy stomach bleeding;
- prevention of injuries of the gastric mucosa against the background of long-term drug therapy (NSAID-gastropathy);
- aspiration pneumonitis (as a reliable prophylaxis).
Method of application and dosage
The medical drug Famotidine is intended for course use orally. The doctor discusses daily doses on an individual basis. The therapeutic solution containing the component of the same name becomes the so-called "emergency help", intended for use intravenously (slowly, drip for 2 minutes) or intramuscularly.
Tablets
The drug Famotidine is supposed to take a long course. The tablets are swallowed whole, not chewed, washed down with plenty of liquid. Daily doses and course of treatment depend on the diagnosis made by the doctor, are reflected in the instructions for use:
|
Disease |
Single dose, mg |
Number of receptions |
Course of treatment, weeks |
Note |
|
peptic ulcer, erosive gastroduodenitis |
If necessary, the dose is increased to 80-160 mg per day. |
|||
|
signs of dyspepsia |
3–6 weeks |
|||
|
reflux esophagitis |
6–12 months |
The course of treatment is determined by the specialist individually. |
||
|
aspiration of gastric juice into the respiratory tract (for the purpose of prevention) |
once before surgery |
|||
|
Zollinger-Ellison syndrome |
every 6 hours |
individually |
For medical reasons, the dose is increased to 160 mg every 6 hours. |
|
|
stomach ulcer prevention |
3–4 weeks |
Preparations with Famotidine solution
Such medicines are intended for use intravenously or intramuscularly. The drug is injected into a vein slowly over 2 minutes. According to the instructions, the recommended dose is 20 mg every 12 hours. To exclude the development of aspiration pneumonitis, before surgery, 20 mg of the drug is injected deep into the gluteal muscle. Dosage adjustments are made on an individual basis.
special instructions
Famotidine tablets are not recommended for malignant tumors of the stomach (carcinoma). Otherwise, the indicated medication masks unpleasant symptoms, thereby complicating the course of the pathological process. Instructions for use contains a complete list of instructions for patients:
- Unpleasant symptoms of the disease disappear after 1-2 weeks of continuous use of Famotidine. Treatment is required to be completed, after performing a control examination of the stomach for the integrity of the mucous membrane.
- In order to exclude a sharp increase in the acidity of gastric juice and an increase in the unpleasant symptoms of a stomach or duodenal ulcer, this drug should be canceled gradually.
- If the functional activity of the stomach is pathologically reduced by a sluggish or recurrent disease, the treatment may not exclude the addition of a secondary infection in the mucous membrane of the digestive tract.
- The results of skin allergic tests for histamine during therapy with this medication may be false negative.
- During treatment, it is required to adhere to a diet, avoiding dishes and foods in the daily diet that can irritate the inflamed gastric mucosa.
- Smoking patients and patients with burns may require an increase in the prescribed dose, since these provoking factors sharply weaken the desired therapeutic effect.
- Since the drug under study depresses the functioning of the nervous system, in the treatment of stomach ulcers, and not only, it is required to temporarily give up driving, engaging in intellectual activity.
According to the instructions for use, when carrying a fetus and lactation, this medication is not prescribed. Clinical studies of these categories of patients have not been carried out in practice. Such treatment can only harm the health of the unborn or nursing child.
famotidine for children
The drug is prescribed to children from the age of 12 years (according to the instructions, it can be given from 3 years). Previously, it is better not to use Famotidine. It has been clinically proven that after this age the risk of side effects is an order of magnitude lower. Pharmaceutical prescription and further treatment should proceed under the supervision of a pediatrician.
drug interaction
Famotidine tablets are prescribed in combination with representatives of other pharmacological groups. The instructions for use provide information on drug interactions:
- When used simultaneously with Ketoconazole or Itraconazole, it is necessary to wait a two-hour interval, otherwise the absorption of the components slows down.
- The indicated medication is approved for use with solutions of sodium chloride, dextrose.
- In combination with drugs that depress the function of the bone marrow, the risk of exacerbation of neutropenia increases.
- With simultaneous use with Aminophylline, Metronidazole, Aminophenazone, Phenazone, Lidocaine, Caffeine, Phenytoin, tricyclic antidepressants, indirect anticoagulants, Glipizide, Diazepam, Metoprolol, Buformin, Theophylline, the metabolism of the latter is disturbed.
- The drug increases the absorption of clavulonic acid, Amoxicillin from the digestive tract into the systemic circulation.
- Antacids and sucralfates, on the contrary, slow down the degree of adsorption.
Side effects and overdose
At the beginning of the course, the patient's condition may deteriorate sharply. The instructions for use contain information about side effects that require discontinuation of the drug or dosage adjustment:
- digestive tract: signs of dyspepsia, dry mouth, pancreatitis, hepatitis, increased activity of liver enzymes, diarrhea, constipation, gastralgia (abdominal pain), flatulence (bloating), heartburn;
- nervous system: dizziness, depression, insomnia, visual and auditory hallucinations, migraines, confusion, lack of clarity of vision;
- cardiovascular system: arrhythmia, tachycardia, bradycardia, arterial hypotension, vasculitis (vascular damage), impulse blockade through the atrioventricular node;
- bone marrow and hematopoietic organs: thrombocytopenia (platelet decline), agranulocytosis (granulocyte deficiency), pancytopenia, asystole (lack of blood cells);
- reproductive system: decreased libido, amenorrhea (lack of menstruation), gynecomastia in men (breast enlargement), increased prolactin concentration in women (hyperprolactinemia);
- musculoskeletal system: myalgia (muscle pain), arthralgia (joint pain);
- allergic reactions: bronchospasm, skin rash, urticaria, itching and swelling of the epidermis, hyperemia of the skin, alopecia.
With a systematic excess of the doses prescribed by the doctor, the patient's condition worsens. Overdose symptoms: decrease in blood pressure, collapse, tremor of the limbs, motor activity, tachycardia, prolonged vomiting. To eliminate unpleasant symptoms, there is an urgent need for hemodialysis. Further treatment is postsymptomatic (gastric lavage and intake of intestinal sorbents).
Contraindications
The drug Famotidine is not allowed to be used according to indications for all patients. Medical contraindications are detailed in the instructions:
- children's age up to 3 years;
- period of pregnancy;
- lactation;
- cirrhosis of the liver with portosystemic encephalopathy;
- renal and hepatic insufficiency of a complicated form;
- individual intolerance to the body of the active substances of the drug.
Terms of sale and storage
According to the instructions for use, Famotidine is a prescription drug. You can buy it at a pharmacy, store at a temperature of 15 to 25 degrees. Shelf life - 3 years from the date of issue indicated on the package.
Famotidine's analogs
If the chosen medicine does not help or harms health, it must be urgently replaced. Reliable analogues of Famotidine and brief characteristics:
- Gastromax. These are effective pills for chronic ulcers and gastritis of the stomach. The medicine is supposed to be taken 1 hour after a meal, while the tablet is thoroughly chewed in the oral cavity.
- Gastrotide. The drug has several forms of release, which are prescribed for exacerbation of gastric ulcer. The solution for injection is allowed to be administered only intravenously.
- Kvamatel. These are tablets from the group of H2 histamine receptor blockers. The patient is prescribed 1 or 2 tablets. twice a day - in the morning and in the evening. The course of treatment is 1-2 months.
- Ulfamid. This is another prescription drug with famotidine in the chemical composition. According to the instructions, it is supposed to take 1 tablet in the morning and in the evening. On the recommendation of a doctor, the prescribed dose is increased.
- Famodingexal. The drug reduces the content of hydrochloric acid and pepsin in the stomach, controls the volume of gastric juice after stimulation, removes the symptoms of ulcers and gastritis. According to the instructions, the treatment is prescribed for a course of up to 2 months.
- Famozol. This is a budget drug for the treatment of peptic ulcer and gastroesophageal reflux disease, which is produced in the form of a solution for injection. Dosages depend on the diagnosis, are described in the instructions for use.
- Famosan. Such tablets have many similarities with Famotidine. Intended for oral use. Daily doses and recommendations of specialists are identical, described in the instructions.
Famotidine or Omeprazole - which is better
Both medications are recommended for use if necessary to reduce the concentration of hydrochloric acid in the stomach. Doctors often prescribe Omeprazole tablets, since a positive trend in these is observed 30 minutes after taking a single dose. The action of the second medicine is slow, relief comes only after 1-2 hours. In addition, omeprazole inhibits the production of acid, while famotidine only stops its release at the last stage. It is forbidden to take two medications at the same time, otherwise the acidity of the stomach decreases as much as possible.
Famotidine price
The cost of tablets depends on the quantity in the package, the concentration of the active substance, the manufacturer and the rating of the capital's pharmacy. For example, the price of 40 mg, No. 30 varies up to 100 rubles.
Diseases of the digestive system tend to disrupt the normal functioning of all internal organs. For the correct appointment of treatment, an examination and consultation with a doctor is required.
Famotidine is widely used to eliminate the symptoms of diseases of the digestive tract, the instructions for use of which contain detailed recommendations for various applications.
Form and composition
The drug Famotidine for the elimination of diseases of the digestive organs is available in the form of biconvex tablets. The tool has two types of dosage: 20 mg (brown shell) and 40 mg (pink shell) of the active substance.
The required type of dosage is selected individually for each patient.
Ingredients of the medicinal product:
The medicinal substance is located in 10 pieces on a special plate, there may be 2 or three plates in the package, depending on the required amount of the drug.
pharmachologic effect
- The medicinal substance Famotidine is aimed at reducing inflammatory formation in the digestive organs.
- Famotidine belongs to the group of substances that reduce the secretion of glands in the stomach and prevents the development of ulcerative lesions of the mucous membranes.
- Reduces the activity of hydrochloric acid, enhances the natural protective functions of the mucous membrane.
- When applied, it increases the secretion of gastric mucus, which stops bleeding and reduces unpleasant symptoms.
- Supports the normal functioning of the digestive organs, reduces the likelihood of deposition of toxins and toxins.
Pharmacokinetics
- After application, the tablet quickly dissolves in the stomach and is absorbed by the mucous membranes.
- The highest level of action of Famotidine occurs 3 hours after application.
- Partially excreted after 5 hours with the help of the kidneys and liver.
- It does not affect the work of other organs, when used correctly, it normalizes the acid-base level in the stomach.
- It tends to color urine yellow when excreted.
Pharmacodynamics
- The active ingredient famotidine reduces the negative effect of hydrochloric acid and has protective functions in places of damage to the gastric mucosa.
- Reduces the level of pepsin in the digestive organs, starts the natural processes of regeneration of damaged cells.
- It has the ability to penetrate human soft tissues, including breast milk.
- The result after the application of the substance lasts from 6 to 10 hours, depending on the individual characteristics of the body.
Indications for use
The substance Famotidine requires compliance with strict instructions for use and is prescribed for the following situations:
Treatment with this remedy requires compliance with the rules for observing a special type of diet, which enhances the result from the use of Famotidine.
Contraindications
- individual intolerance to the constituent components
- pregnancy
- lactation
- age up to 12 years
- kidney disease
- cirrhosis of the liver
- age over 60
It is forbidden to use Famotidine during a period when there is a sharp decrease in human immunity.
Dosing method
The medicinal substance is used twice a day, the tablet is swallowed whole and washed down with plenty of clean water.
The course of treatment is prescribed individually, but the following approximate dosages are available:
- ulcer of the digestive organs- applied twice a day for 5 weeks;
- increased secretion of the digestive organs- Apply once a day at bedtime. The course of treatment is prescribed individually;
- Soliten-Ellison disease- the substance is applied every 6 - 7 hours, one tablet of 20 mg., The course of application depends on the severity of the disease;
- prevention of ulcerative lesions of the digestive organs- applied once a day for 2 weeks;
- bleeding- is prescribed twice a day in complex therapy, a course of no more than 3 weeks;
- aspiration of gastric juice- applied twice a day for 7 weeks;
- to normalize acid- alkaline balance is applied once before bedtime for 14 days.
Use in children
Famotidine is forbidden to use for children under 12 years of age, otherwise side effects may occur that threaten the normal functioning of internal organs.
Use during pregnancy and lactation
Famotidine is contraindicated during pregnancy and breastfeeding. Active components tend to cross the placenta and disrupt the development of the kidneys of the fetus. There is also a property to be transmitted with breast milk. If treatment is necessary, the child is recommended to be transferred to artificial feeding.
Use in violation of the functioning of the liver and kidneys
If the patient has a decrease in the functioning of the kidneys and liver, the drug is prescribed in a reduced dosage. Since the withdrawal time of substances increases to 15 hours and can cause an overdose.
drug interaction
Do not use with alcoholic beverages, may contribute to the formation of poisoning.
Side effects
Famotidine tends to cause unpleasant side effects:
- From the side of the nervous system- dizziness, hallucinations, depression.
- From the digestive organs- Nausea, vomiting, stomach pain, lack of appetite.
- From the side of the work of the cardiac organs and the circulatory system- tachycardia, violation of pressure, the formation of blood clots in the blood vessels;
- From the reproductive system- Violation of impotence, lack of libido.
- allergic reactions, which can manifest itself in varying degrees of skin rash.
In rare cases, there may be a decrease in vision and a feverish state.
special instructions
To increase the effectiveness of the use of the drug Famotidine, the following special instructions must be observed:
- use the substance only for its intended purpose for the treatment of diseases of the digestive organs;
- a disease of the digestive organs is associated with other types of damage to the internal organs;
- if after treatment the patient loses body weight, it is recommended to stop treatment;
- treatment is recommended to be carried out strictly under the supervision of the attending physician;
- in the absence of timely use of the drug, it is forbidden to double the dosage;
The composition of the medicinal substance contains lactose, so the patient must be warned before starting treatment. To reduce the likelihood of allergic reactions.
Overdose
Medical experts say that compliance with the recommended dosage of the substance rarely causes an overdose.
However, the following symptoms may occur if Famotidine is used incorrectly:
- vomit
- sharp pain in the stomach
- loss of consciousness
- pressure reduction
If such symptoms appear, it is necessary to rinse the stomach with boiled water, contact the nearest medical facility.
Storage conditions
Famotidine is stored in a place away from children without direct sunlight. Shelf life is not more than 4 years from the date marked on the package.
The price of the drug
You can buy the drug Famotidine at any pharmacy by providing a prescription from your doctor.
- You can buy the drug at a price 45 - 60 rubles for a pack of tablets with 20 mg of the active ingredient, the price depends on the number of plates.
- If a higher dosage is needed, the cost varies. from 65 to 90 rubles for tablets with 40 mg of the active substance.
Analogues
If any side effects occur when using the drug Famotidine, you can use drugs of a similar effect, which will be prescribed by the attending physician.
The following analogues are most often used:
- Gastrocidin- the active component of the substance famotidine is used to treat diseases of the digestive organs. It is an analogue of the drug substance Famotidine. Released strictly according to the prescription. average cost 130 rubles.
- gistak- a drug in the form of tablets that eliminate the formation of ulcerative lesions and have a restorative property. Contraindicated for children under 18 years of age. The drug has a strong effect and can contribute to the occurrence of a large number of side effects. Price 50 rubles.
- Ranitidine- the product has an increased level of absorption and quickly eliminates unpleasant symptoms in the digestive tract. If used incorrectly, it can contribute to the formation of a large number of side effects. average cost 40 rubles.
- Atsilok- affects the digestive organs in a similar way as the substance Famotidine. However, it tends to be better tolerated by the body and cause fewer adverse reactions. The drug is prescribed by a doctor, released strictly by prescription. Price 250 rubles.
- Cimetidine- is prescribed for the treatment of digestive organs. In complex types of the disease can be used for intramuscular injection. Rarely used for complex treatment. If it is necessary to use additional medicines, it is necessary to study the constituent components in detail. Promotes the formation of side effects when used with alcoholic beverages. Price 260 rubles.
- Zantac- a preparation for the preparation of a solution for oral administration. Not recommended for use with other similar substances. Price 220 rubles.
- Kvamatel- the substance is used to increase the protective functions of the stomach and reduce the production of excessive amounts of gastric juice. It is prescribed for the treatment of many diseases of the digestive tract. Price 140 rubles.
Each of the drugs similar in their action to Famotidine can affect the state of health in different ways and is not suitable for every patient. Therefore, before using any remedy, it is recommended that you carefully study the instructions for contraindications and possible adverse reactions.
Conclusion
The drug Famotidine has a general effect on the digestive organs and starts the natural processes of restoring damaged areas. The active ingredient famotidine has a deep level of penetration and eliminates a large number of various diseases.
Experts recommend that during the period of treatment with Famotidine, a special type of diet should be observed, the action of which is aimed at eliminating the use of harmful foods and facilitating the digestion of food by the stomach. The method of nutrition is prescribed by the doctor for each patient individually.
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