To successfully combat this unpleasant disease, there are many drugs, including Rinza's drug.
Before you continue reading: If you are looking for an effective method for getting rid of the common cold, pharyngitis, tonsillitis, bronchitis or colds, then be sure to check out this section of the site after reading this article. This information has helped a lot of people, we hope it will help you too! So, now we return to the article.
The main symptoms of a cold are:
- sore or sore throat;
- profuse nasal discharge or congestion;
- headache;
- fast fatiguability;
- cough;
- general malaise.
A cold is an acute respiratory disease that can be caused by various factors (hypothermia, lowered immunity, and others). Disease-causing bacteria are the main culprits in the common cold.
The greatest threat posed by colds is for newborns, the elderly, people with diseases of the cardiovascular system and those with chronic pulmonary diseases (asthma, emphysema, chronic bronchitis). If treatment is not started at the first sign of a cold, then it can turn into quite serious diseases of the nasopharynx and pulmonary tract.
Rinza is one of the most popular drugs used at the first sign of a cold. Rinza has various dosage forms: tablets, Lorsept, Rinzasip. They help to significantly relieve the symptoms of a cold.
In this article you will find answers about the use of the drug: detailed instructions, taking the drug during pregnancy and during lactation, Rinza's medicine for children, how to take, action, composition and cost.
Rinz's pills
Rinza tablets are a combination remedy that soothes the symptoms of a cold:
- the temperature drops;
- the work of the nose improves;
- headaches disappear.
Rinza tablets have an antihistamine and analgesic effect.
The shape of the tablets is round, the color is pink with splashes of white or dark pink, the edges are beveled, there is a dividing line on one side.
The tablets contain: paracetamol, caffeine, phenylephrine hydrochloride, chrofenamine maleate and various excipients (silicon dioxide, corn starch, magnesium stearate, purified talc, purified water and others).
Action of active substances
Paracetamol, which is part of Rinza's tablets, has an antipyretic and analgesic effect, actively affecting the centers of thermoregulation and pain. That is, paracetamol inhibits the formation of prostaglandins in the brain.
Caffeine affects the psychomotor of the brain (vasomotor and respiratory centers are excited) and the stimulation of cardiac activity. There is an increase in physical and mental performance, drowsiness and a feeling of fatigue go away. Also, caffeine enhances the effect of analgesics.
Phenylephrine hydrochloride has a vasoconstrictor effect. As a result, swelling and increased filling of blood vessels with blood in the nose, its paranasal sinuses and nasopharynx (hyperemia) are eliminated.
Chlorphenamine maleate blocks receptors that cause an allergic reaction, but does not suppress the release of antibodies. Lacrimation, discomfort in the nasopharynx (itching) is eliminated. The manifestations of acute rhinitis are suppressed.
Indications for use and pharmacokinetics
The use of Rinza should be started at the first signs of a cold and other infectious diseases (influenza, ARVI), which are caused by fever, acute rhinitis and headaches. In case of a cold, the drug quickly improves well-being.
Each ingredient in Rinse's drug has its own pharmacokinetics, which does not affect the pharmacokinetics of the remaining components of the drug.
Paracetamol is absorbed in the gastrointestinal system of the body in a short period of time and almost completely. In blood plasma, its maximum concentration after administration reaches its value in about 2 hours. It is processed by the liver and excreted from the body in the urine almost completely in the form of metabolites (about 5% unchanged). Paracetamol is evenly distributed throughout the body fluids, and approximately 25% of its amount combines with proteins in the blood plasma.
Caffeine is absorbed quickly enough in the gastrointestinal system of the body and is distributed throughout all its tissues and fluids (including the central nervous system and embryonic tissues, breast milk). It is rapidly processed by the liver and excreted in the urine (3% unchanged). Decomposes in blood plasma in about three hours.
Phenylephrine hydrochloride after oral administration is absorbed in a fairly short time in the gastrointestinal tract. In blood plasma, its concentration reaches its maximum value within about 2 hours. It is quickly processed by the liver and excreted in the urine.
Chrophenylamine maleate is absorbed in a fairly short period of time in the gastrointestinal system of the body. It begins to act in almost 20 minutes. The therapeutic effect reaches its maximum value within 2 hours and continues to last for 4-6 hours. It is processed by the liver. Processed products and approximately 5% of the ingredient are excreted unchanged in the urine. Small amounts pass into breast milk.
How to take Rinza tablets?
Rinza for children is prescribed from 6 years old, one tablet no more than 5 times a day. The time interval between doses of the drug should be at least four hours.
Adults are prescribed one or two tablets, no more than 12 tablets per day. The time interval between doses should be at least four hours.
Treatment should be carried out for no more than 7 days.
Contraindications and side effects
- the presence of sensitivity to the components of the drug;
- children under the age of 6;
- period of pregnancy and lactation;
- arterial hypertension;
- atherosclerosis of the coronary arteries;
- severe forms of diabetes mellitus.
Rinza should be taken with caution in liver failure, renal failure, glaucoma, prostatic hyperplasia, diabetes mellitus, thyrotoxicosis. With the simultaneous administration of monoamine oxidase inhibitors (MAO), antidepressants, beta-blockers and in the presence of chronic bronchitis and pulmonary emphysema.
Before taking the drug, contact your doctor if you have such an indication. Rinza helps effectively, but caution comes first.
Digestive system: liver dysfunctions, stomach pains, nausea, vomiting, dry mouth.
Organs of vision: increased intraocular pressure, dilated pupil (mydriasis), weakening of the ability to distinguish small objects at close range (paresis of accommodation).
Circulatory system: various types of anemia, agranulocytosis, pancytopenia, methemoglobinemia, thrombocytopenia.
Urinary system: kidney necrosis, urinary retention.
Respiratory system: bronchial obstruction.
Allergic reactions: skin rash, urticaria, itching, angioedema.
Dizziness, sleep disturbance, increased blood pressure, hyperexcitability.
When used for a long period of time in high doses: toxic effects on the kidneys and liver (renal colic, interstitial nephritis), changes in blood composition.
Overdose is caused by paracetamol when taken more than 10 g. Symptoms: nausea, vomiting, decreased appetite, pallor of the skin, toxic hepatitis, hepatonecrosis, increased prothrombin time, increased activity of hepatic transaminases.
Appropriate treatment: gastric lavage. After that, activated carbon and symptomatic therapy are prescribed. It is administered 8 hours after an overdose of methionine, after 12 hours - N-acetylcysteine.
special instructions
During treatment, it is desirable to monitor blood counts and the functional state of the liver.
Do not use medicines that contain paracetamol, have hypnotic and anxiolytic effects (tranquilizers). It is necessary to refrain from drinking alcohol (possibly toxic effects on the liver), from driving and from engaging in other activities that require increased concentration of attention and speed of mental and motor reactions.
If there is no improvement in the symptoms of diseases within 5 days, you should consult a doctor to find out the indications. Rinza is contraindicated for long-term use.
Rinza's interaction with other medications
Rinza's drug enhances the effects of monoamine oxidase inhibitors, alcohol and various sedative drugs.
In the case of the simultaneous use of antidepressants, antipsychotics, drugs against Parkinson's syndrome, phenothiazine derivatives and Rinsa's drug, the possibility of dry mouth, urinary retention and constipation increases. When taking Rinza's drug and glucocorticosteroids, the risk of developing glaucoma increases.
The simultaneous use of Rinza's drug with diphenin, barbiturates, rifampicin, carbamazepine increases the risk of developing an increased toxic effect of paracetamol on the liver. Also, paracetamol reduces the effects of diuretic drugs when taken simultaneously.
The simultaneous use of monoamine oxidase inhibitors, furazolidone and chlorphenamine increases the likelihood of a hypertensive crisis, overexcitation and hyperpyrexia.
The adrenomimetic effect of phenylephrine is enhanced by tricyclic antidepressants. Phenylephrine and halothane increase the risk of ventricular arrhythmias. The simultaneous administration of phenylephrine and guanetedine reduces the hypotensive effect of the second and increases the alpha-adrenostimulating activity of the first.
Rinza Lorsept
Rinza Lorsept refers to antiseptics used locally in ENT practice and dentistry. These are lozenges with different flavors (lemon, orange, blackcurrant and honey-lemon).
Active ingredients: 2,4-dichlorobenzene alcohol and amylmetacresol;
Excipients: citric acid monohydrate, sucrose, liquid dextrose, anise oil.
Orange Flavored Lorsept Rinza uses Sunset Yellow, Peppermint Oil and Orange Oil;
Lemon flavored rhinza lorsept uses quinoline yellow dye, peppermint oil and lemon oil;
For rinza lorsept with honey and lemon flavor, caramel and yellow sunset colors, mint oil, honey flavor additive and lemon oil are used;
For rinza lorsept with black currant flavor, the dyes diamond blue and carmoisin, mint oil and black currant flavor are used.
Rinza Lorsept: action and indications for use
The drug Rinza Lorsept for local use has anesthetic, anti-inflammatory and analgesic effects. All active components of the drug are aimed at combating a wide range of bacteria. They also have antifungal effects. Interferes with the further development of infections in the upper respiratory tract.
Rinza Lorsept relieves discomfort in the upper respiratory tract, eliminates pain and irritation in the throat. Helps reduce nasal congestion.
Indications for use:
Inflammation of the mucous membranes in the mouth (thrush, gingivitis, stomatitis);
Infections and inflammatory diseases of the nasopharynx, throat, larynx (pharyngitis, tonsillitis, laryngitis);
Occupational diseases in speakers, teachers, workers in the coal and chemical industries.
Mode of application. Contraindications special instructions
The drug Rinza Lorsept is used for adults and children over the age of 6 years. Suck one lozenge every two to three hours, but not more than 8 tablets per day. The use of Lorsept Rinza is most effective in the initial manifestations of the common cold.
Contraindications are the age of children less than six years old and special sensitivity to the components of the drug.
Overdose symptom is gastrointestinal discomfort. When discomfort occurs, symptomatic treatment is prescribed.
Special instructions: in the case when the symptoms of the disease last more than three days, are accompanied by headaches, fever or other manifestations, you should consult a doctor.
In case of illness, patients with diabetes mellitus should take into account that sucrose is part of the Rinza Lorsept drug.
Do not exceed the dose of the drug indicated in the instructions.
Rinzasip
Rinzasip is a powder for solution preparation. Has orange, lemon and black currant flavors.
Rinzasip refers to combination remedies that soothe cold symptoms:
- the temperature drops;
- the work of the nose improves;
- headaches disappear.
Rinzasip has an antihistamine and analgesic effect.
The tablets contain: paracetamol, caffeine, phenylephrine hydrochloride, chrofenamine maleate and various excipients (sodium saccharin, sodium citrate, citric acid, sucrose).
For Orange Rinzasip: Sunset Yellow Dye and Flavor (Orange).
For lemon Rinzasip: yellow quinoline dye and flavor (lemon).
For blackcurrant Rinzasip: carmoisin dye and flavorings (fruit, raspberry and blackcurrant).
Method of using Rinzasip
Rinzasip is indicated for children over 15 years of age and adults. Take one sachet one hour after a meal no more than four times a day. The time interval between doses is at least four hours.
Rinza powder is dissolved completely in 250 ml hot water. You can add honey or sugar to taste.
Treatment should be no more than 5 days.
Taking Rinza's drugs during pregnancy and lactation
Rinza is contraindicated during pregnancy. This is especially true for Rinza tablets and Rinzasip. The medicine "Lorsept" can be taken during pregnancy, taking into account the possibility of risk. The drug for colds in pregnant women can only be prescribed by a doctor.
When breastfeeding (lactation period), the drug is contraindicated. An exception may be the drug Rinza Lorsept.
Rinza for children
Many parents ask themselves the question: "How to drink rinza for children?"
Rinza's drug in tablets is prescribed from the age of 6, one tablet no more than 5 times a day. The time interval between taking Rinza tablets should be at least four hours.
Rinza Lorsept is prescribed for children over the age of 6 years. Suck one lozenge every two to three hours, but not more than 8 tablets per day.
Rinzasip is indicated for children over 15 years old. Take one sachet one hour after a meal no more than four times a day. The time interval between doses is at least four hours.
You should be very careful when treating children!
Cost and manufacturer
The price of Rinza's drugs is from 60 to 100 rubles, depending on the dosage form of the drug.
Manufacturer: Unique Pharmaceutical Laboratories.
Teraflu or Rinza - which is better?
Often people are interested in the question, which is better: Teraflu or Rinza?
Everything is very individual. The composition of the active ingredients is similar. Rinza's drugs have a lower price than Teraflu.
Arbidol or Rinza?
These are drugs of various kinds. Arbidol stimulates the immune system. Rinza acts differently. Everything is also individual for everyone.
Video "Why isn't a cold being treated?"
The article above and comments written by readers are for informational purposes only and do not call for self-medication. Consult with a specialist regarding your own symptoms and diseases. When treating any drug, always use the instructions that come with it in the package, as well as the advice of your healthcare professional, as a basic guideline.
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Rinza
Description overdue on 05/19/2014
- Latin name: Rinza
- ATX code: N02BE71
- Active ingredient: Paracetamol (Paracetamol), Caffeine (Coffein), Phenylephrine Hydrochloride (Phenylephrine), Chlorphenamine Maleate (Chlorphenamine)
- Manufacturer: UNIQUE PHARMACEUTICAL Laboratories, India
Rinza's composition
Additional substances: magnesium stearate, sodium methyl parahydroxybenzoate, corn starch, sodium carboxymethyl starch, colloidal silicon dioxide, povidone (K-30), talc, crimson dye.
Release form
It is produced in tablets of a round flat form without a shell, with a notch on one side and a beveled edge, pink interspersed with white or burgundy. 10 such tablets in one blister, one blister in a cardboard box.
pharmachologic effect
- psychostimulating;
- anti-congestive (edema reduction);
- antihistamine;
- analgesic;
- antipyretic.
Pharmacodynamics and pharmacokinetics
Rinza is a combination medicine, the list of its effects is the sum of the effects of the components of the drug.
Paracetamol has analgesic and antipyretic effects. Relieves pain in the head, back, joints, throat, pain arising from colds, and also reduces fever.
Paracetamol inhibits the enzymes cyclooxygenase-1 and cyclooxygenase-2, reduces the synthesis of prostaglandins and affects the center of thermoregulation of the nervous system. In inflamed tissues it is blocked by special enzymes, therefore, the inactivation of cyclooxygenase-1 and -2 in them is insignificant, this explains the insignificant anti-inflammatory effect. However, paracetamol effectively stops the production of prostaglandins in the cells of the nervous system, as a result, it only reduces fever and does not affect normal body temperature. Paracetamol does not affect the gastric mucosa, unlike other non-steroidal anti-inflammatory drugs. Reception of paracetamol in therapeutic doses does not affect water-mineral metabolism and other types of metabolism.
Phenylephrine is an alpha-adrenergic agonist. Reduces the lumen of blood vessels, resulting in edema and hyperemia of the mucous membranes of the nasopharynx, nose and sinuses.
Chlorphenamine is a blocker of histamine receptors and has an anti-allergic effect, and also reduces edema and hyperemia of the mucous membranes of the nasopharynx cavity, nose and sinuses, helps to weaken exudative manifestations.
Caffeine has a stimulating effect on the nervous system, which reduces fatigue and drowsiness, and leads to an increase in mental and physical performance. Strengthens and accelerates the analgesic effect of paracetamol.
Paracetamol is rapidly absorbed from the middle sections of the digestive system, actively binds to plasma proteins. The highest concentration in the blood - 1 hour after consumption. Paracetamol can cross the blood-brain barrier and the placenta.
Indications for use
What does Rinz's medicine help with? Most people, who have visited a pharmacy at least once, see this drug on the shelf and ask this question.
In winter and autumn, it is easy to catch a cold, accompanied by nasal congestion and fever, which helps Rinza. The drug relieves headache and toothache, pain in joints, muscles, neuralgia, pain in burns, injuries. However, not all patients like to take pills, from which they prefer analogues of the drug in other forms (for example, powder).
Acute rhinitis (including allergic ones), pharyngitis and sinusitis are also indications for taking the drug.
Contraindications
- hypersensitivity to the drug and its components;
- arterial hypertension in severe form;
- severe forms of atherosclerosis of the vessels of the heart;
- severe forms of heart failure, including rhythm disturbances;
- severe forms of renal and hepatic failure;
- pyloroduodenal obstruction;
- congenital increase in the content of bilirubin in the blood;
- Dubin-Johnson syndrome;
- bronchial asthma;
- chronic lung disease with obstructive symptoms;
- pheochromocytoma;
- hyperfunction of the thyroid gland;
- diabetes;
- blood diseases;
- a decrease in the content of leukocytes or hemoglobin in the blood;
- increased intraocular pressure and glaucoma;
- insomnia;
- hyperplasia of the prostate with difficulty urinating;
- epilepsy and convulsive conditions;
- alcohol addiction;
- age up to 15 years;
- pregnancy and lactation;
- hypersensitivity to xanthine derivatives (theobromine, theophylline).
Do not use with antidepressants, beta-blockers, monoamine oxidase (MAO) inhibitors and within half a month after the end of MAO inhibitors.
Side effects
In the overwhelming majority of cases, the drug is well tolerated by patients. Side effects are rare and this, as a rule, is associated with long-term use of the drug in doses exceeding those indicated in the instructions.
The following side effects are possible:
- disorders of the digestive tract - heartburn, pain in the stomach, increased salivation, impaired appetite, nausea, vomiting, stool retention, loose stools, increased activity of liver enzymes, other liver disorders, hepatonecrosis (when using high doses of the drug);
- metabolic disorder - hypoglycemia;
- cardiac disorders - heart palpitations, bradycardia, rhythm disturbances, shortness of breath, heart pain;
- vascular disorders - increased blood pressure;
- neurological disorders - anxiety, weakness, headache, irritability, insomnia, irritability, depressive conditions, dyskinesia, tinnitus, convulsive states, coma;
- mental disorders - hallucinations;
- disorders of the genitourinary system - nephritis, dysuria, renal colic, difficulty urinating;
- on the part of the hematopoietic system - anemia (including aplastic and hemolytic), pancytopenia, neutropenia, agranulocytosis, thrombocytopenia, leukopenia;
- respiratory disorders - bronchospasm of patients with allergies to aspirin and other non-steroidal anti-inflammatory drugs;
- disorders of the organs of vision - dry eyes, dilated pupils, impaired accommodation, increased intraocular pressure;
- disorders of the immune system - skin rash, urticaria, itching, toxic epidermal necrolysis, anaphylactic shock, Stevens-Johnson syndrome, Quincke's edema.
Instructions for use of Rinza
The instruction for Rinza clearly says how to take the pills, and does not differ in the frequency and mode of administration from the instructions for Rinza sip powder.
Method of administration - oral. Adults and children over the age of 15 take one tablet every 6-8 hours for no more than five days. The drug should be taken one and a half hours after eating. Drink with the required amount of water. The maximum dose of the drug is 4 tablets per day.
Overdose
Paracetamol overdose. Paracetamol has a toxic effect on an adult after taking a dose of grams. Overdose manifestations:
- pallor of the skin, lack of appetite, nausea, diarrhea, stomach discomfort;
- an increase in the level of bilirubin, a decrease in the value of prothrombin;
- hepatotoxic effect - pain in the hypochondrium on the right, weakness, sweating, jaundice, hepatomegaly, increased activity of liver enzymes;
- in rare cases, hepatonecrosis may develop with the addition of hepatic encephalopathy (deterioration of cognitive functions and indicators of higher nervous activity), disseminated intravascular coagulation syndrome, metabolic acidosis, hypoglycemia, rhythm disturbances, convulsive state, coma, cerebral edema, collapse.
Even less often, liver dysfunctions can develop with lightning speed with the simultaneous addition of renal failure. When taking especially large doses, the following are possible: disorientation, agitation, sleep disturbance, dizziness, cardiac arrhythmias, the development of pancreatitis. With long-term administration of large doses of the drug, aplastic anemia, neutropenia, agranulocytosis, pancytopenia, leukopenia, thrombocytopenia may develop.
Symptoms of a phenylephrine hydrochloride overdose: dizziness, confusion, arrhythmia, tremors of the extremities, nervousness, anxiety.
Symptoms of an overdose of chlorphenmine maleate: dilated pupils, photophobia, dry mouth, hyperthermia, intestinal atony, bradycardia, arterial hypotension.
Symptoms of a caffeine overdose: headache, tremors, irritability, extrasystoles.
Overdose treatment: gastric lavage, activated charcoal intake, symptomatic therapy (methionine after 8 hours and N-acetylcysteine after 12 hours of overdose), monitoring of indicators of external respiration and cardiac activity. When seizures appear, diazepam is recommended.
Interaction
Avoid combining Rinza with other drugs containing phenylephrine, paracetamol, chlorphenamine or caffeine.
Rinza enhances the effect of beta-blockers, MAO inhibitors and sedatives. When Rinza is taken with antidepressants, antipsychotics and antiparkinsonian drugs, urinary retention, dry mouth, and constipation may occur.
Paracetamol reduces the effectiveness of diuretics and increases the possibility of toxic effects on the liver when taken simultaneously with barbiturates, carbamazepine, diphenin, rifampicin.
Barbiturates reduce the antipyretic effect of paracetamol. The speed of absorption in the digestive tract of paracetamol can be increased when used together with metoclopramide and domperidone. The effects of paracetamol are enhanced when combined with ascorbic acid, codeine, chlorphenamine, scopolamine, propyphenazone, and caffeine. Taking paracetamol with non-steroidal anti-inflammatory drugs increases the risk of renal complications. One of the main components of the drug phenylephrine hydrochloride exhibits adrenomimetic properties when combined with tricyclic antidepressants.
The use of Rinza tablets reduces the ability of guanethidine to reduce blood pressure. The combined use of phenylephrine hydrochloride with digoxin tablets and other cardiac glycosides can lead to the development of arrhythmias and even heart attack. Phenylephrine to reduce the effectiveness of beta-blockers and other antihypertensive drugs (eg, reserpine and methyldopa).
Caffeine in Rinza improves the bioavailability of other analgesics, antipyretics, enhances the effects of some xanthine derivatives, alpha and beta adrenergic agonists, psychostimulants. Cimetidine, isoniazid, hormonal contraceptives potentiate the effect of caffeine. Caffeine reduces the effects of opioid analgesics, sedatives, anesthetics, and drugs that depress the central nervous system. Caffeine decreases the concentration of lithium in the blood.
Terms of sale
The drug is dispensed without a prescription.
Storage conditions
Store at temperatures up to 250C, in a dry place protected from sunlight. Keep out of the reach of children.
Best before date
special instructions
Do not exceed the dose indicated in the instructions. Do not use together with sedatives, hypnotics and other drugs containing paracetamol or other substances present in Rinza.
If the drug must be used for a long time, it is necessary to monitor the functional state of the liver and the state of the blood.
During the period of using the drug, you should not abuse coffee, strong tea, and other tonic drinks, since sleep problems are possible, as well as the appearance of irritability, heart palpitations, dizziness, arrhythmias.
The use of Rinza may affect the result of the doping control.
If the temperature rise persists for more than three days, you should consult your doctor.
Rinza's analogs
The most frequently asked question is the comparative effectiveness of this group of drugs. Rinza has a higher paracetamol content than Teraflu, and the latter is also caffeine-free. Therefore, the expected therapeutic effect from taking Rinza is higher than from taking Theraflu. However, it is worth remembering that a higher content of active ingredients increases the risk of side effects.
For kids
The drug is contraindicated in children under 15 years of age.
With alcohol
During the period of treatment with this drug, it is necessary to stop drinking alcohol.
With antibiotics
You should refrain from taking Rinza and hepato- and nephrotoxic antibiotics together.
Rinza during pregnancy and lactation
Pregnancy and lactation are contraindications for taking Rinza.
Reviews about Rinza
Numerous reviews of doctors and patients are positive, there are practically no reports of overdose or side effects.
Often a dispute arises among consumers about a drug - is it an antibiotic or not? Rinza does not belong to antibiotics or their substitutes and does not have an antibacterial effect.
Rinza's Price
The price of tablets in Russia is about 80 rubles - this is about the same as tablets of a similar composition. The price of a package of Rinzasip (powder 10 pcs.) Is about 30% more expensive than tablets.
In Ukraine, the average cost of Rinza is 113 hryvnia.
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BIOSPHERE
Education: Graduated from Vitebsk State Medical University with a degree in Surgery. At the university, he headed the Council of the Student Scientific Society. Further training in 2010 - in the specialty "Oncology" and in 2011 - in the specialty "Mammology, visual forms of oncology".
Work experience: Work in the general medical network for 3 years as a surgeon (Vitebsk emergency hospital, Liozno CRH) and part-time as a regional oncologist and traumatologist. Work as a pharmaceutical representative throughout the year at the Rubicon company.
He presented 3 rationalization proposals on the topic "Optimization of antibiotic therapy depending on the species composition of microflora", 2 works won prizes in the republican competition-review of student research papers (1 and 3 categories).
Tatiana: Vladimir, I will share my experience. Saw tamoxifen for 2 years and 3 months. instead of 5 years. Now.
Inna: Unfortunately, the cytomegalovirus in my body was never able to defeat Isoprinosine.
galina aleksandrovna: I can't decide on this drug - they write contraindications - diabetes mellitus, which one.
Alla: Tsetrin 1 tab per day and Comfoderm cream. I gave my mom injections, she also had her whole body in.
All materials presented on the site are for informational and informational purposes only and cannot be considered a doctor-prescribed treatment method or sufficient advice.
Rinza: Instruction
Composition and dosage form of Rinz
Film-coated tablets. In 1 tablet of paracetamol - 500 mg, phenylephrine hydrochloride 10 mg, caffeine 30 mg and chlorphenamine 2 mg; as auxiliary substances are: crimson dye 4R, colloidal, corn starch, silicon dioxide, sodium methylhydroxybenzoate, povidone (K-30), magnesium stearate, glycolate, talc and purified water.
10 and 20 pcs. packaged.
Pharmacological activity of Rinz
Paracetamol has anti-inflammatory, analgesic and antipyretic effects. And the mechanism of action is based on the suppression of the synthesis of prostaglandins, in particular, in the hypothalamus and in the center of thermoregulation.
Phenylephrine hydrochloride is an alpha1-adrenergic agonist. It constricts blood vessels, reduces hyperemia and swelling of the mucous membranes in the upper respiratory tract and paranasal sinuses.
Chlorphenamine maleate - blocks the activity of histamine H1 receptors, thereby providing an anti-allergic effect, reducing the permeability of the vessels of the mucous membrane of the upper respiratory tract, eliminating tearing, itching in the nose and eyes.
Caffeine improves cerebral circulation; increases the analgesic properties of paracetamol.
Indications for prescribing Rinza
Rinza is prescribed for symptoms of acute respiratory infections (ARVI) and colds, which are accompanied by a runny nose, fever, headache; with pain syndromes: neuralgia, toothache and headache, myalgia, arthralgia, pain of a traumatic and burn nature; acute and allergic rhinitis, sinusitis, rhinopharyngitis, inflammation of the paranasal sinuses.
Contraindications to the appointment of Rinza
The main contraindications for the use of Rinza are: high sensitivity to certain components of the drug; cardiovascular diseases (in particular myocardial infarction, atherosclerosis, aortic stenosis,); tachyarrhythmia, arterial and pulmonary hypertension, hypercapnia, pheochromocytoma, hypovolemia, metabolic acidosis, predisposition to vasospasm, hypoxia, glaucoma, sleep disorder, hyperexcitability, diabetes mellitus, porphyria, epilepsy, thyrotoxicosis; serious disorders of kidney and liver function; systemic blood diseases; hypertrophy of the prostate; children under 15 years of age, pregnancy and lactation.
Rinza: Application
Application and dosage
Rinza must be taken orally. Adults and children from 15 years old - 1 table. 3 r / day with plenty of liquid. The break between receptions is 8 hours. The duration of treatment is a maximum of 5 days.
Rinz side effects
An allergic reaction may occur: (skin rash, swelling, itching), nausea, epigastric pain; thrombocytopenia, anemia, agranulocytosis, dizziness, increased blood pressure, hyperexcitability, sleep disorder, mydriasis, paresis of accommodation of intraocular pressure, urinary retention, dry mouth.
In the case of long-term use of Rinza in large doses, various kinds of anemia develop, hepatotoxic effect, met hemoglobinemia, pancytopenia are manifested; nephrotoxicity.
Prescribing Rinz during pregnancy or lactation
Rinza during pregnancy is prescribed when the expected benefit is significantly higher than the possible risk to the fetus. It is also imperative to take into account the fact that in the first trimester of pregnancy, it is necessary to exclude a long course of treatment with paracetamol and its use in large doses.
If it becomes necessary to use the drug during lactation, the lactation process stops for the duration of treatment.
Special instructions for the appointment of Rinza
- If there is no improvement in clinical parameters after 3 days after administration, or if the signs of the disease have not disappeared after 5 days, consult a doctor immediately.
- You do not need to use Rinza's drug at the same time as other drugs that contain paracetamol.
- While taking the drug, it is necessary to exclude the use of alcohol, sleeping pills, tranquilizers.
- Care should be taken to prescribe the medicine together with beta-blockers, MAO inhibitors.
Rinz's drug interactions
With the combined appointment of paracetamol (the main active ingredient in Rinz's composition) with drugs that can induce liver enzymes, its hepatotoxicity increases. Paracetamol also increases the hepatotoxicity of chloramphenicol when used simultaneously. In the case of a combination of paracetamol and azidothymidine, neutropenia may develop.
Rinz overdose
It manifests itself, as a rule, after taking paracetamol more than 10-15 g at a time. It manifests itself by symptoms: nausea, vomiting, anorexia, hepatonecrosis, pallor of the skin, an increase in prothrombin time, an increase in the activity of hepatic transaminases.
Impact on the ability to drive vehicles and other mechanisms
Taking Rinza, you need to be careful when performing types of work that require high concentration of attention, speed of mental and motor reactions.
Rinza drug price
The drug is available over the counter without a prescription. The cost of one package can vary from 65 rubles. up to RUB 87 Which makes Rinza accessible to most citizens.
Rinza during pregnancy, especially in the early stages, is not the best drug for treating colds. Effectively stopping the symptoms of the disease, the drug has a teratogenic effect on your baby. If you have no doubts about whether you can drink Rinza during pregnancy, we strongly recommend that you read the article to the end. Once you finish reading, your opinion may change dramatically.
General description of Rinza
Rinza's drug is widely represented on the pharmacological market of our country. You can buy the product in almost any pharmacy without presenting a prescription from a doctor.
Rinza is a targeted combination drug that is contraindicated during pregnancy. It has pronounced:
- pain reliever;
- antipyretic;
- antihistamine effect.
Due to the presence of the following substances in Rinza, it allows you to eliminate the symptoms of acute respiratory disease as soon as possible:
- paracetamol - stops the growth of prostaglandins;
- caffeine - stimulates heart activity, stimulates the centers of the brain;
- phenylephrine hydrochloride - has a vasoconstrictor effect;
- chlorphenamine maleate - blocks receptors responsible for allergic reactions.
Please note that each of the components of the drug has its own pharmacokinetics. However, all of them are absorbed within a short time in the human gastrointestinal system, and metabolic products are excreted by the kidneys in the urine.
Release form of the drug
Rinza is available in the form of flat, round tablets. They are packaged in blisters of ten, which makes them easy to store and receive.
However, you can purchase Rinzasip, which is similar in its medicinal effect and composition, but in powder form. The only caveat is that the content of paracetamol in Rinzasip is slightly higher. Can pregnant women drink Rinzasip powder as a safe alternative to Rinza? Absolutely not. A qualified specialist will always select a milder, gentle, but equally effective drug for the treatment of ARVI.
In addition to Rinza tablets intended for oral use, you can find drugs such as Rinza Lorsept or Anesthetics. These are lozenges that are actively used in ENT practice and dentistry.
Indications for use
Rinza is prescribed for acute respiratory viral infections, accompanied by:
- fever, increased body temperature;
- rhinorrhea;
- pain syndrome.
In addition, Rinza's reception is indicated when diagnosing:
- pharyngitis;
- tonsillitis;
- laryngitis.
For any of the listed diseases during pregnancy, a positive answer to the question: is it possible to take Rinza, is accepted only if the benefits to the mother are many times greater than the risks to the fetus.
Instructions for use
The instructions for the drug indicate that Rinza should be taken in the form of tablets after meals, washed down well with purified, warm water. The dosage is one tablet three to four times a day for an adult or a child over fifteen years of age.
Important: it is forbidden to exceed the daily dose of the drug, as side effects may develop.
The maximum course of treatment is five days. If there is no tangible improvement in the condition or undesirable effects appear, you must stop taking the drug and seek the advice of a specialist.
Attention: pregnant women can drink Rinza only in a situation where there is no adequate alternative, while the dosage and duration of treatment is determined by the attending physician.
Rinzasip powder is taken as follows. The contents of one sachet, one to two hours after a meal, are diluted in 200 ml of boiled water and taken. The frequency of use of the drug is two to four times a day with an interval of more than four hours. The duration of therapy is also five days.
Tip: If you wish, you can add a teaspoon of sugar or a serving of honey to enhance the taste of the drink.
Side effects in pregnant women
The list of possible side effects from taking Rinza is impressive. The most dangerous, in our opinion, are:
- angioedema;
- thrombocytopenia;
- glucosuria;
- bronchial obstruction;
- papillary necrosis;
- tachycardia;
- pain in the stomach;
- renal colic.
It is erroneous to believe that drinking Rinza during late pregnancy is less dangerous. In reality, this is not the case. In women in a position, Rinza's reception can provoke the manifestation of the above side effects, as well as allergic reactions such as:
- itchy skin;
- rash;
- hives.
If any of these conditions occur, it is important to seek immediate medical attention to prevent the development of more serious conditions.
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Contraindications
The drug has a lot of side effects and contraindications. Serious restrictions on the use of Rinza concern:
- individual intolerance to the components of the drug;
- severe diabetes mellitus;
- arterial hypertension;
- atherosclerosis of the coronary arteries in the acute phase.
Treatment should be carried out under the strict supervision of medical personnel, the attending physician, if the patient has:
- violations in the work of the kidneys;
- liver pathologies;
- dysfunction of the prostate gland.
Also, you should not drink Rinza to children under fifteen years of age, women during pregnancy and breastfeeding, since through milk you can transfer the medicine to the baby. Substances in Rinza's composition can penetrate into breast milk and, as a result, have a negative effect on the baby's body.
In this article, you can read the instructions for the use of the medicinal product. Rinza... Reviews of website visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Rinza in their practice are presented. A big request to more actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, which may not have been declared by the manufacturer in the annotation. Rinza's analogs in the presence of available structural analogs. Use for the treatment of symptoms of colds, flu and SARS (runny nose, fever and sore throat) in adults, children, as well as during pregnancy and breastfeeding. Composition of the preparation.
Rinza- a combined preparation.
Paracetamol has analgesic and antipyretic effects. Reduces pain associated with colds - sore throat, headache, muscle and joint pain, reduces fever.
Phenylephrine is an alpha1-adrenergic agonist. It has a vasoconstrictor effect, reduces edema and hyperemia of the mucous membranes of the upper respiratory tract and paranasal sinuses.
Chlorphenamine - a blocker of histamine H1-receptors, has an antiallergic effect, reduces swelling and hyperemia of the mucous membranes of the nasal cavity, nasopharynx and paranasal sinuses, eliminates itching in the eyes and nose, reduces exudative manifestations.
Caffeine has a stimulating effect on the central nervous system, which leads to a decrease in fatigue and drowsiness, and to an increase in mental and physical performance.
Compound
Paracetamol + Caffeine + Phenylephrine hydrochloride + Chlorphenamine maleate + excipients.
2,4-dichlorobenzyl alcohol + Amylmetacresol + excipients (Rinza Lorsept).
2,4-dichlorobenzyl alcohol + Amylmetacresol + Lidocaine hydrochloride monohydrate + excipients (Rinza Lorsept Anesthetics).
Indications
- symptomatic treatment of "colds", ARVI (including influenza), accompanied by fever, pain, rhinorrhea;
- treatment of infectious and inflammatory diseases of the oral cavity and pharynx (tonsillitis, pharyngitis, laryngitis).
Forms of issue
Tablets.
Lozenges (Rinza Lorsept and Lorsept Anesthetics).
There are no other dosage forms, be it powder or capsules.
Instructions for use and reception scheme
Rinza
Adults and children over 15 years of age are prescribed 1 tablet 3-4 times a day. The maximum daily dose is 4 tablets. The course of treatment is no more than 5 days.
Rinza Lorsept
Adults and children over 6 years of age: dissolve 1 tablet every 2-3 hours. The maximum daily dose is 8 tablets.
Rinza Lorsept Anesthetics
Locally. Adults and children over 12 years of age: Dissolve 1 tablet every 2-3 hours. The maximum daily dose is 8 tablets. The duration of the course of treatment is 5-7 days.
Side effect
- skin rash;
- hives;
- angioedema;
- dizziness;
- violation of falling asleep;
- increased excitability;
- increased blood pressure;
- tachycardia;
- dry mouth;
- nausea, vomiting;
- epigastric pain;
- increased intraocular pressure;
- anemia, thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia;
- renal colic;
- glucosuria;
- interstitial nephritis;
- papillary necrosis;
- bronchial obstruction.
Contraindications
- severe atherosclerosis of the coronary arteries;
- arterial hypertension (severe course);
- diabetes mellitus (severe course);
- concomitant use of tricyclic antidepressants, MAO inhibitors, beta-blockers;
- simultaneous administration of drugs containing components of the Rinza drug;
- pregnancy;
- lactation period;
- children up to 15 years old (Rinza Lorsept - up to 6 years old, Lorsept Anesthetics - up to 12 years old);
- hypersensitivity to the components of the drug.
Application during pregnancy and lactation
The appointment of Rinza's drug during pregnancy and lactation is contraindicated.
Application in children
The drug is contraindicated in children and adolescents under 15 years old (Rinza Lorsept - up to 6 years old, Lorsept Anesthetics - up to 12 years old).
special instructions
During the period of using Rinza's drug, you should refrain from drinking alcohol, sleeping pills and anxiolytic drugs (tranquilizers).
Do not take at the same time with other preparations containing paracetamol.
Influence on the ability to drive vehicles and use mechanisms
During the period of treatment, one should refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.
Drug interactions
Rinza enhances the effects of MAO inhibitors, sedatives, ethanol (alcohol).
With the simultaneous use of Rinza's drug with antidepressants, antiparkinsonian drugs, antipsychotics, phenothiazine derivatives, the risk of urinary retention, dry mouth, and constipation increases.
Glucocorticosteroids (GCS), when used simultaneously with Rinza, increase the risk of developing glaucoma.
Paracetamol reduces the effectiveness of diuretic drugs.
Ethanol (alcohol) enhances the sedative effect of antihistamines.
The use of chlorphenamine simultaneously with MAO inhibitors, furazolidone can lead to hypertensive crisis, agitation, hyperpyrexia.
Tricyclic antidepressants enhance the adrenomimetic effect of phenylephrine, the simultaneous administration of halothane increases the risk of ventricular arrhythmia.
Phenylephrine reduces the hypotensive effect of guanethidine, which, in turn, enhances the alpha-adrenergic activity of phenylephrine.
With the simultaneous use of Rinza with barbiturates, diphenin, carbamazepine, rifampicin and other inducers of liver microsomal enzymes, the risk of developing the hepatotoxic effect of paracetamol increases.
Analogs of the drug Rinza
Structural analogues in terms of the active substance and pharmacological effect (anilides in combinations):
- Adjikold Hotmix;
- Adjikold;
- AnGriCaps maxim;
- Antigrippin;
- AntiFlu;
- AntiFlu Kids;
- Apap S Plus;
- Brustan;
- Vicks Active Symptomax;
- Gevadal;
- Gripex;
- Grippostad;
- Grippostad Good Knight;
- Grippostad C;
- GrippoFlu for colds and flu;
- Grippoflu extra for colds and flu;
- Gripand;
- Gripand HotActive;
- Daleron C;
- Daleron C junior;
- Children's Tylenol for colds;
- Dolaren;
- Dolospa tabs;
- Ibuklin;
- Infloblock;
- Influnet;
- Caffetin;
- Kaffetin Cold;
- Codeine + Paracetamol;
- Codelmixst;
- Coldact Flu Plus;
- Coldrex;
- Coldrex MaxFlu;
- Coldrex Knight;
- Coldrex Hotrem;
- Coldrex Junior Hot Drink;
- Coldfree;
- Coffeedon;
- Lemsip;
- Maxicold;
- Maxicold Reno;
- Mexavit;
- Migraine;
- Migrenol;
- Mulsinex;
- Next;
- Neoflu 750;
- Novalgin;
- Padewix;
- Panadein;
- Panadol Extra;
- Panoxen;
- Paracodamol;
- Paracetamol Extra;
- Paracetamol Extra for children;
- Pentalgin;
- Pentaflucin;
- Pentaflucin daily;
- Plivalgin;
- Colds;
- Passage forte;
- Rinzasip;
- Rinzasip with vitamin C;
- Rinikold;
- Rinikold HotMix;
- Saridon;
- Solpadein;
- Stopgripan;
- Stopgripan Forte;
- Strimol plus;
- Tylenol for colds;
- TeraFlu;
- TeraFlu for flu and colds;
- TeraFlu for flu and colds Extra;
- TeraFlu Extra;
- TeraFlu Extratab;
- Toff plus;
- Trigan D;
- Fastorik;
- Fastorik plus;
- Febriset;
- Femizol;
- Fervex;
- Fervex for children;
- Fervex rhinitis;
- Flukoldin;
- Flucoldex;
- Flucomp;
- Flustop;
- Khairumat;
- Andrews Unswehr;
- Efferalgan with Vitamin C.
In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and see the available analogues for the therapeutic effect.
Thank you
The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. A specialist consultation is required!
What kind of drug is Rinza?
Rinza Is a combination drug that is aimed at combating the symptoms of colds and acute respiratory diseases ( ARI), including influenza. This drug contains several components at once that act on almost all symptoms of acute respiratory diseases ( ARI), which saves the patient from taking several drugs at once. Rinza contains paracetamol, caffeine, phenylephrine hydrochloride and chlorphenamine maleate. These substances are recognized as safer and more effective in clinical practice. Rinza mechanism of action
The medicinal properties of this drug are due to the presence in it of components that have antipyretic, analgesic, vasoconstrictor, antiallergic and psychostimulating effects.Paracetamol is a drug that has antipyretic and analgesic effects. Due to its properties, it reduces pain cider, namely, sore throat, headache, joint pain and muscle pain, and reduces fever. All this is associated with the inhibition of the synthesis of prostaglandins in the center of thermoregulation, which is located in the hypothalamus.
Phenylephrine hydrochloride is a vasoconstrictor. It acts on the α1-adrenergic receptors, which are located on the blood vessels of the nasal mucosa, and leads to their narrowing. As a result, the volume of blood flowing to the nose decreases and nasal congestion is relieved. This makes nasal breathing much easier.
Chlorphenamine maleate is a remedy that has an anti-allergic effect - it eliminates itching of the eyes, nose, swelling and hyperemia of the mucous membranes of the nasal cavity, nasopharynx and paranasal sinuses. This is due to the fact that this substance is a histamine inhibitor ( mediator of immediate allergic reactions).
Caffeine is a drug that has a stimulating effect on the central nervous system, which ultimately leads to a decrease in sleepiness and fatigue, increasing mental and physical performance.
Is Rinza an antibiotic or not?
Antibiotics are drugs that can inhibit the growth, development and reproduction of microbes. By the type of antimicrobial action, 2 types of antibiotics are distinguished - those that lead to the death of microorganisms and those that inhibit the growth and reproduction of bacteria. Also, antibiotics are divided into several groups according to their chemical structure - macrolides, aminoglycosides, tetracyclines and others.Rinza is not an antibiotic, but refers to a drug that has anti-inflammatory, analgesic and antipyretic effects as a result of inhibition of prostaglandin synthesis by inhibiting the activity of the enzyme cyclooxygenase ( COX).
What is the difference between Rinza and antiviral drugs ( remantadine, ingavirin)?
Antiviral drugs are drugs that are aimed at combating viral diseases ( flu, measles, mumps and others). Today, there are many antiviral drugs that can be obtained in various ways. However, the process of obtaining them is rather complicated, due to which the price of these drugs may be overstated.The risk of developing arrhythmias and myocardial infarction may increase.
Barbiturates, rifampicin, tricyclic antidepressants
Drugs that have a depressing effect on the central nervous system.
In case of an overdose and simultaneous administration with paracetamol, the risk of toxic effects on the liver increases.
Corticosteroids(prednisolone, hydrocortisone)
Rinza overdose
As a rule, an overdose is due to paracetamol. If the patient has taken more than 10 g of paracetamol, then he has liver damage. Also, intake of more than 5 g can lead to liver damage, but the patient may have several risk factors - regular excessive alcohol consumption, the presence of malnutrition, cystic fibrosis, HIV infection, long-term treatment with phenobarbital, rifampicin and other drugs that stimulate liver enzymes ...In case of an overdose of paracetamol, side reactions such as anorexia ( lack of appetite), nausea, vomiting, abdominal pain, pallor of the skin, increased sweating, general malaise, jaundice, acute liver failure, hepatomegaly ( enlarged liver). Sepsis ( blood poisoning), fungal infection, bleeding from the gastrointestinal tract, cerebral edema, coma, hypoglycemia ( a decrease in the concentration of glucose in the blood), respiratory failure, pancreatitis and others.
There are also cases in which an overdose of other components of the rhinza is not excluded.
In case of an overdose of phenylephrine, nausea, vomiting, irritability, insomnia, headache, convulsions, tachycardia and increased blood pressure are observed.
Symptoms of a caffeine overdose are abdominal pain, nausea, vomiting, chills, fever, arrhythmia, tachypnea ( rapid breathing), headache. Anxiety, insomnia, weakness, irritability, loss of appetite, tremors, hypokalemia ( a decrease in the concentration of potassium in the blood), hyponatremia ( a decrease in the concentration of sodium in the blood), hyperglycemia ( increased blood glucose concentration) and other pathological conditions.
Chlorpheniramine overdose can lead to hyperthermia ( overheating), dilated pupils, dry mouth, urinary retention, tachycardia, nausea, vomiting. Disorientation, hallucinations, psychosis, seizures and cardiac arrhythmias can also develop with an overdose of this substance.
Treatment of a suspected overdose includes gastric lavage and the appointment of activated charcoal by mouth and an antidote ( in the case of paracetamol, acetylcysteine acts as an antidote) intravenously. This treatment is effective up to 24 hours after taking paracetamol. Further treatment must be carried out in a specialized department of the hospital with the help of doctors.
Contraindications to the use of rinza
An absolute contraindication to the appointment and use of this drug is hypersensitivity to the ingredients that are included in the composition. Severe allergic reactions may occur if this medication is ingested. ). phenytoin, carbamazepine, rifampicin, isoniazid and others);
Can Rinza tablets be taken by children?
Rinza is a drug that consists of several components. This drug must be used in children strictly following the instructions for use. So, Rinza tablets can be taken by children over 15 years old. In this case, the treatment of colds and flu in children should be carried out with the help of a specialist.Can rinza be drunk if there is no fever?
The substance that has an antipyretic effect in the preparation of Rinza is paracetamol. Paracetamol provides its antipyretic effect only from a body temperature in the range from 37.8 to 38 degrees. If the patient has only mild malaise, and he does not have an increased body temperature, then in this case, it is not recommended to take this drug for prophylaxis. It should be remembered that antipyretic drugs, like any drugs, have side effects.Application during pregnancy and breastfeeding
Given the fact that there are no clinical data on the safety of the drug during pregnancy and breastfeeding, the appointment of Rinza is contraindicated in this category of patients. As you know, paracetamol is one of the safest non-steroidal anti-inflammatory drugs, and it does not adversely affect the health of a pregnant woman, as well as during breastfeeding. However, phenylephrine and pheniramine maleate can adversely affect fetal development and end up in breast milk. In this case, it is necessary to transfer the baby to artificial feeding.Can Rinza be combined with alcohol?
This drug must not be taken at the same time as drinking alcohol in order to avoid toxic liver damage. Alcohol has a toxic load on the liver, as well as the components of the drug. Also, Rinza should not be prescribed to patients who suffer from chronic alcoholism.How does Rinza affect driving?
Rinza is a drug that can make you sleepy. In this case, you must refrain from driving a car. It is also necessary to exclude engaging in activities that require high concentration, quick reactions and attention.Price ( price) of the Rinza preparation in the cities of Russia
The cost of drugs in pharmacies depends on the country of origin, the cost of manufacturing, transportation and storage. Also, the cost is determined by the form of release, dosage of active substances and other factors. Prices of the drug in various cities of Russia
Town | Release form |
|||
Tablets ( 10 pieces) | Powder for oral solution ( rinzasip with vitamin C) | Powder for solution preparation for children ( rinzasip for children, 10 sachets, 3 g each) |
||
5 sachets 5 g each | 10 sachets 5 g each |
|||
Moscow | 188 rubles | 195 rubles | 277 rubles |
|
Saint Petersburg | 186 rubles | 195 rubles | 312 rubles | 249 rubles |
Novosibirsk | 150 rubles | 208 rubles | ||
Nizhny Novgorod | 209 rubles | 212 rubles | 308 rubles | 310 rubles |
Voronezh | 180 rubles | 180 rubles | 280 rubles | 265 rubles |
Samara | 200 rubles | 205 rubles | 305 rubles | |
Tyumen | 177 rubles | 286 rubles | 286 rubles |
|
Yaroslavl | 188 rubles | 190 rubles | 286 rubles |
|
Kazan | 195 rubles | 200 rubles | 300 rubles | 297 rubles |
Krasnoyarsk | 180 rubles | 280 rubles | ||
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