In this article, you can read the instructions for using the drug Hepa-Merz. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Hepa-Merz hepatoprotector in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Hepa-Merz analogues in the presence of existing structural analogues. Use for the treatment of liver diseases in adults, children, as well as during pregnancy and lactation. The composition of the drug.
Hepa-Merz- hypoammonemic drug. It has a detoxifying effect, reducing the elevated level of ammonia in the body, in particular, in liver diseases. The action of the drug is associated with its participation in the ornithine Krebs urea cycle (activates the cycle by restoring the activity of liver cell enzymes: ornithine carbamoyl transferase and carbamoyl phosphate synthetase). Promotes the production of insulin and growth hormone. Improves protein metabolism in diseases requiring parenteral nutrition. It helps to reduce asthenic, dyspeptic and pain syndromes, as well as normalize increased body weight (with steatosis and steatohepatitis).
Compound
L-ornithine L-aspartate + excipients.
Pharmacokinetics
Ornithine aspartate dissociates into its components - the amino acids ornithine and aspartate, which are absorbed in the small intestine by active transport through the intestinal epithelium. It is excreted in the urine through the urea cycle.
Indications
- acute and chronic liver diseases accompanied by hyperammonemia;
- hepatic encephalopathy (latent or severe), incl. as part of complex therapy for impaired consciousness (precoma and coma);
- steatosis and steatohepatitis (of various origins);
- as a corrective additive to preparations for parenteral nutrition in patients with protein deficiency.
Release forms
Granules for the preparation of a solution for oral administration 3 g (sometimes erroneously called tablets or granules).
Concentrate for solution for infusion (injections in ampoules for injection) (sometimes erroneously called powder).
Instructions for use and scheme of use
Granules
The drug is administered orally, 1-2 sachets of granules dissolved in 200 ml of liquid, 3 times a day, after meals. The course of treatment is from 10 to 30 days and depends on the severity of the disease.
Ampoules
Intravenously injected up to 40 ml (4 ampoules) per day, dissolving the contents of the ampoules in 500 ml of infusion solution.
With hepatic encephalopathy (depending on the severity of the condition), up to 80 ml (8 ampoules) per day are injected intravenously.
The duration of infusion, frequency and duration of treatment are determined individually. The maximum infusion rate is 5 g/h.
Side effect
- nausea, vomiting;
- abdominal pain;
- flatulence;
- diarrhea;
- pain in the limbs;
- allergic reactions.
Contraindications
- severe renal failure (serum creatinine more than 3 mg / 1 dl);
- lactation period (breastfeeding);
- children's age (due to insufficient data);
- hypersensitivity to the components of the drug.
Use during pregnancy and lactation
The drug should be used with caution during pregnancy.
The drug is contraindicated for use during breastfeeding.
special instructions
If nausea or vomiting occurs, the rate of administration of the drug should be reduced.
Influence on the ability to drive vehicles and control mechanisms
In case of hepatic encephalopathy, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.
drug interaction
The drug interaction of the drug Hepa-Merz is not described.
Analogues of the drug Hepa-Merz
Structural analogues for the active substance:
- Ornitsetil.
Analogues by pharmacological group (hepatoprotectors):
- L-Methionine;
- S-adenosylmethionine;
- Antraliv;
- Berlition;
- Bonjigar;
- Brenziale forte;
- Vitanorm;
- Gepabene;
- Hepatosan;
- Hepatofalk planta;
- Hepaphor;
- Heptor;
- Heptral;
- Geptrong;
- Glutargin;
- Glutargin alkoklin;
- Deepana;
- Cavehol;
- Karsil;
- Karsil Forte;
- Kedrostat;
- Criomelt MN;
- L-ornithine-L-aspartate;
- Laennec;
- Legalon;
- Liv 52;
- Livodex;
- Livolife Forte;
- Lipoic acid;
- Lipoid;
- Maksar;
- Methionine;
- Metrop;
- Milife;
- Molixan;
- Octolipen;
- Progepar;
- Rezalut Pro;
- Ropren;
- Sibektan;
- Silegon;
- Silibinin;
- Silimar;
- Silymarin;
- Sirepar;
- Thiolipon;
- Thiotriazoline;
- Tykveol;
- Urdox;
- Urso 100;
- Ursodez;
- Ursodeoxycholic acid;
- Ursodex;
- Ursoliv;
- Ursor;
- Ursosan;
- Ursofalk;
- Phosphogliv;
- Phosphogliv forte;
- Phosfonciale;
- Hepabos;
- Choludexan;
- Exhol;
- Erbisol;
- Eslidin;
- Essentiale N;
- Essentiale forte N;
- Essential phospholipids;
- Essliver;
- Essliver forte.
In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.
Cases of liver disease have become much more frequent in recent years, and this is due to the deterioration of the environment and the quality of food. Often in practice there are cases of poisoning with drugs, low-quality alcohol or other chemicals. Therefore, medicine does not stand still and develops new drugs (tablets, powders, solutions) for the treatment and prevention of liver diseases.
For many years, hepatoprotectors and enzymes have been leading in the treatment of liver pathologies. But their effectiveness was achieved after prolonged use, while the course of treatment often ranged from 3 months to six months.
The result was not always positive, so there was a need to develop more modern and powerful tools. Thus, the German company Merz Pharma has developed an effective Hepa-Merz remedy for the treatment of serious liver pathologies - granules and a concentrate for mixing a solution for infusion.
Mechanism of action, indications, features of admission
According to the therapeutic effect, the drug is classified as a hepatoprotective drug, that is, a remedy for restoring and protecting the liver from negative factors. The effect of the application depends on the general detoxification and hepatoprotective action.
The composition of Hepa-Merz includes amino acids - aspartate and ornithine, necessary for the treatment of the liver. In combination, they perform the following actions:
All these actions and chemical processes contribute to the activation of the liver cells. Consequently, asthenic, dyspeptic and pain syndrome decreases. A detoxification reaction occurs, which has a beneficial effect on both the liver itself and the body as a whole. In addition, the drug allows you to correct the increased body weight of a person.
From a chemical point of view, the action of ornithine is manifested in the catalysis of such an enzyme as carbamoyl phosphate synthetase and ornithine carbamoyl transferase. In combination with the synthesis of urea, its formation is activated and the level of ammonia decreases.
In accordance with the classification of pharmacological groups, Hepa-Merz is classified as a drug for the treatment of liver diseases, that is, detoxifying agents and hepatoprotectors.
In composition, five grams of the drug contains L-ornithine and L-aspartate at a dosage of three grams. Auxiliary substances include citric acid, citric, orange flavor, dyes, fructose and other components.
Based on the International Classification of Diseases 10th revision, Hepa-Merz is included in the treatment algorithms for many diseases. Among them are a violation of urea metabolic cycles, alcoholic liver dystrophy, liver failure, fatty degeneration, and unspecified liver pathologies.
According to medical criteria, Hepa-Merz is used for the treatment and preventive action in such conditions:
For prophylactic purposes, Hepa-Merz is prescribed for frequent overeating, the consequences of alcohol abuse or taking narcotic drugs, drugs.
A method for treating liver pathologies involves two options for taking Hepa-Merz. In the first method, it is necessary to take the drug (granules) parenterally, dissolving one or two sachets of the drug in a glass of water or other liquid. The course of treatment with a prepared solution (taken three times a day after meals) is selected individually by a doctor.
The second method of treatment involves prescribing the drug in the form of injections. To do this, the concentrate is diluted in half a liter of infusion solution and prescribed up to 4 ampoules per day. Severe conditions, as in cirrhosis or coma, require the introduction of a solution of up to 8 ampoules. The doctor selects the exact dosage and course of therapy.
It is worth remembering about allergic reactions, so it is necessary to take the drug after a sensitivity test, after which the prescribed treatment will not cause negative consequences.
With intravenous use of the drug, there is a certain way to use Hepa-Merz. Strict control of drug administration is needed at a rate not exceeding 5 grams per hour.
Contraindications and side effects
As for any pharmacological drug, there are special indications, contraindications and side effects for Hepa-Merz. Contraindications include severe renal failure and hypersensitivity to the components of the drug.
It is also forbidden to use the remedy for children and women during breastfeeding (lactation). There are no special instructions on whether or not to take Hepa-Merz for pregnant women, but due to the incomplete knowledge of the drug, it is possible to take it with caution and only under the supervision of a doctor.
Side effects include disorders of the digestive tract, that is, the appearance of nausea, vomiting, abdominal pain, flatulence and diarrhea. These symptoms are rare.
Conditions such as pathologies associated with the musculoskeletal system are rare, but are described in the instructions and may occur. They also include pain in the extremities. The components of the drug may cause allergic reactions.
Interaction with drugs of other groups has not been studied. In case of an overdose of Hepa-Merz, pronounced side effects occur. To eliminate an overdose, lavage of the gastrointestinal tract is prescribed. It is also necessary to take activated charcoal or other sorbents. At the same time, symptomatic therapy is prescribed.
Hepa-Merz: instructions for use and reviews
Hepa-Merz is a hypoammonemic drug for the treatment of diseases of the liver and biliary tract.
Release form and composition
Dosage forms of the drug:
- Granules for the preparation of a solution for oral administration: a mixture of white and orange granules (5 g in sachets, in a cardboard box of 10 or 30 sachets);
- Concentrate for solution for infusion: transparent liquid of light yellow color (10 ml in dark glass ampoules, 10 ampoules in a cardboard box).
Active ingredient - L-ornithine L-aspartate:
- 1 sachet - 3 g;
- 1 ampoule - 5 g.
Excipients:
- Granules: orange flavor, anhydrous citric acid, sodium saccharinate (sodium saccharin), lemon flavor, sodium cyclamate, polyvinylpyrrolidone (povidone), sunset yellow dye, fructose (levulose);
- Concentrate: water for injections.
Pharmacological properties
Pharmacodynamics
Hepa-Merz is characterized by a detoxifying effect, reducing the increased concentration of ammonia in the body. In particular, this condition occurs in diseases of the liver. L-ornithine-L-aspartate is involved in the ornithine Krebs urea cycle (helps activate the cycle by increasing the activity of liver cell enzymes - carbamoyl phosphate synthetase and ornithine carbamoyl transferase).
The drug improves the production of growth hormone and insulin, normalizes protein metabolism in diseases that require parenteral nutrition. The active component of Hepa-Merz reduces pain, dyspeptic and asthenic syndromes, and also provides a decrease in increased body weight (with steatohepatitis and steatosis).
Pharmacokinetics
L-ornithine-L-aspartate undergoes rapid dissociation into aspartate and ornithine. The drug begins to act within 15-25 minutes after administration and has a short half-life. The active substance is excreted in the urine during the implementation of the urea cycle.
Indications for use
- Chronic and acute liver diseases accompanied by hyperammonemia;
- Latent or severe hepatic encephalopathy.
In addition, the use of the concentrate is indicated as part of the complex therapy of severe hepatic encephalopathy in the patient's condition in precoma or coma, and as a corrective additive to parenteral nutrition in case of protein deficiency.
Contraindications
- Severe degree of renal failure (creatinine level 3 mg / 100 ml);
- The period of breastfeeding;
- Hypersensitivity to the components of the drug.
According to the instructions, Hepa-Merz in granules is prescribed with caution during pregnancy.
Instructions for use Hepa-Merz: method and dosage
- Granules are taken orally, after meals, dissolved in liquid - 1 sachet per 200 ml, 2-3 times a day;
- The concentrate is administered intravenously by drip, dissolved in 500 ml of infusion solution up to 40 ml (4 ampoules) per day. In the case of hepatic encephalopathy (depending on the severity of the condition), up to 80 ml (8 ampoules) per day are administered intravenously. The doctor prescribes the dosage and the period of treatment based on clinical indications individually. The maximum allowable infusion rate is 5 g per hour. In 500 ml of infusion solution, it is recommended to dissolve no more than 60 ml (6 ampoules) of the drug.
Side effects
- Digestive system: in some cases - vomiting, nausea;
- Other: allergic reactions.
Overdose
When taking Hepa-Merz in doses significantly higher than therapeutic, it is possible to increase the severity of side effects of the drug. In this case, the stomach is immediately washed, and activated charcoal and symptomatic therapy are also prescribed.
special instructions
In case of nausea or vomiting, the rate of administration of the drug should be reduced.
Patients diagnosed with hepatic encephalopathy should be careful when engaging in potentially hazardous activities, the implementation of which requires concentration of attention and speed of psychomotor reactions, including when driving.
drug interaction
There are no data on clinically significant drug interactions of the drug.
Analogues
The analogues of Hepa-Merz are: Ornilatex, Ornithine, Ornitsetil.
Terms and conditions of storage
Keep away from children. Store below 25°C.
Shelf life - 5 years.
Terms of dispensing from pharmacies
The granules are available without a prescription, the concentrate is available by prescription.
As part of one ampoule of the concentrate for the preparation of the Hepa-Merz solution, there is 5 g. ornithine aspartate, as well as up to 10 ml. water for injection (auxiliary connection).
Release form
granulate(a mixture of Hepa-Merz white and orange granules) for the preparation of the solution is packaged in sachets of 5 g each. One carton contains 30 sachets.
Concentrate produced in dark glass ampoules with a nominal volume of 10 ml. One carton contains 10 ampoules.
pharmachologic effect
The drug has a hepatoprotective pharmacological effect on the human body. Hepa-Merz belongs to the hypoazotemic pharmacotherapeutic group of drugs.
Pharmacodynamics and pharmacokinetics
active connection ornithine aspartate contained in Hepa-Merz is involved in biosynthesis from urea ammonia (ornithine Krebs cycle) and also contributes to the development STG and insulin , accelerates protein metabolism improves liver function detoxification effect ) and reduces the level ammonia in blood.
The drug is rapidly absorbed in the stomach and enters the blood through intestinal epithelium and excreted from the body in the urine.
Indications for use of Hepamertz
Indications for the use of Hepa-Merz are:
- liver disease , including in chronic or acute form, accompanied by hyperammonemia ;
- hepatic encephalopathy .
As part of complex therapy, the drug is used to treat disturbances of consciousness ( or state precoms ). In addition, Gepa-Merz acts as corrective additive in the therapeutic diet of patients with protein deficiency .
The drug can be used to relieve alcohol poisoning .
Contraindications
The drug is contraindicated in kidney dysfunction (at a blood level of 3 mg / 100 ml. creatine ).
Side effects
It should be noted that such possible side effects of the drug as nausea, on the skin and vomit appear extremely rarely.
Hepa-Merz, instructions for use (Method and dosage)
In accordance with the instructions for use of Hepamerz, the medicine is recommended to be taken after meals. To prepare a single dose of the drug, mix 200 ml. water (preferably at room temperature) with one sachet containing 5 g of granulate powder .
Hepa-Merz solution for infusions, it is administered intravenously at a dose of 20 g (i.e. 4 ampoules of the drug) per day. The recommended average daily therapeutic dose of the drug may be increased to a maximum of 8 ampoules (40 g) per day.
The drug Hepa-Merz is not released in the form of tablets.
Overdose
An increase in the side effects of the drug may signal an overdose of Hepa-Merz. In this situation, the first stop the use of this drug. Patients are washed with a stomach, symptomatic treatment is carried out and prescribed.
Interaction
Currently, there is no information on drug interactions of Hepa-Merz with other drugs.
Terms of sale
OTC dispensing from pharmacies.
Storage conditions
Keep out of the reach of children, at a temperature not exceeding 25°C.
Best before date
special instructions
Before direct intravenous administration of the Hepa-Merz solution, do not dissolve more than 6 ampoules (500 ml solution for infusion) of the drug at a time. In order to exclude vomit and nausea the rate of drug administration should be optimized.
During the use of the drug for treatment hepatic encephalopathy patients are advised to refrain from driving, and also not to work with potentially dangerous mechanisms and not to engage in activities that require increased concentration of attention, and in addition, a quick mental reaction.
Analogues of Hepa-Mertz
Coincidence in the ATX code of the 4th level:Structural analogues of Hepa-Merz a are considered Ornitsetil , as well as Ornithine .
Synonyms
During pregnancy and lactation
Reviews about Gepa-Merz
People who took the drug leave mostly positive feedback on the forums about the drug, noting its effectiveness and a small number of contraindications, as well as side effects. Judging by the reviews of Hepa-Merz, this drug is suitable for a wide range of patients, including children and the elderly.
Hepa-Mertz price, where to buy
The cost of Hepamertz varies by region and dosage form. In pharmacies, this drug can be bought without a doctor's prescription.
average price Hepamerza in ampoules(in a package of 10 pieces, 10 ml each) is 3000 rubles.
Package granulate(10 sachets, 5 mg each) will cost about 650-700 rubles.
- Internet pharmacies in Russia Russia
- Internet pharmacies in Ukraine Ukraine
- Internet pharmacies in Kazakhstan Kazakhstan
ZdravCity
Hepa-Merz gran.sol. 3g/5g n10 Merz
Hepa-Merz gran.sol. 3g/5g n30Cloquet Pharma-Service/ Merz Pharma
Hepa-merz conc.d/inf. 500mg/ml 10ml n10Merz Pharma GmbH & Co. KGaA./B. Braun Melsungen AG
It is quite difficult to cure pathological liver diseases, since in nature there are a small number of drugs that provide immediate help. Until relatively recently, a patient with a similar diagnosis had to tune in to a long and very tedious treatment. However, hepatoprotector Hepa-Merz came to the rescue.
Instructions for use and reviews call this tool the most effective and fastest among the entire line of medicines available on pharmacy shelves aimed at working with the liver.
Release form and composition of the drug
Human health, such an ephemeral state of his body, in the presence of problems and failures, requires the use of medicines. Hepa-Merz is one of them, and its use helps to cope with a fairly large number of problems that form in the liver.
It is available on the market in 2 types:
At the base of the drug are 2 main active ingredients. By themselves, they are amino acids: L-ornithine, as well as L-aspartate. In total, their weight in 1 sachet is 3 grams out of five.
The rest of the Hepa-Merz composition includes: orange or lemon flavors, citric acid, sodium saccharin, sodium cyclamate, yellow and orange dyes, levulose and saccharin.
Ampoules, in addition to the amino acids themselves, which fill half of the composition, are filled with an injection liquid as an auxiliary substance.
Ampoules and sachets are packed only in white cardboard boxes with a pattern. It shows the liver in pink. The name Hepa-Merz is written in black type.
Pharmacology and pharmacokinetics
Hepa-Merz - detoxifies the body, while simultaneously acting on 2 main pathways for the formation of ammonia in the body - urea and glutamine.
This is exactly what the amino acids in the preparation allow to avoid.
The constant participation of ornithine, which biosynthesizes urea from ammonia, ensures a continuous ornithine Krebs cycle.
The body produces insulin and growth hormone, which allows for the maximum therapeutic effect on the liver with a relatively small number of side effects.
There is a gradual activation of the liver's own cells, which have undergone purification and degreasing, and protein metabolism increases.
In general, after entering the body, both amino acids are quickly adsorbed and decomposed into components. Active substances begin to act in just 10-15 minutes. The remains of Hepa-Merz, which were not absorbed by the intestines and passed into the blood, are excreted unchanged in the urine rather quickly.
If earlier it took more than 3 months of constant use for recovery with other medicines, then Hepa-Merz allows you to achieve the same result much faster.
Indications for use
With a careful study of the instructions, you can clearly recognize all the diseases in which Hepa-Merz can be used.
Basically, this hepatoprotector is intended for all acute and chronic diseases that always go along with hyperammonemia. With it, you can easily suppress diseases associated with cirrhosis of the liver and hepatitis.
Hepa-Merz can also be used for preventive purposes, especially for people who abuse the amount of food and alcohol, to remove the hangover syndrome.
In general, the drug has many indications:
Contraindications
In general, the most important contraindications include:
- hypersensitivity or individual intolerance to any of the components of the drug;
- the presence of a thermal stage in renal failure, that is, severe illness;
- in the presence of more than 3 mg of creatine in 100 ml of blood.
Methods of application according to the instructions
Since there are 2 options for Hepa-Merz: a solution in ampoules and granules in sachets, they should be used in different ways. Each of them is best suited for different stages of liver disease, so for serious conditions, it is best to focus on injections.
In general, it is best to leave the choice of the drug and the duration of treatment entirely to the doctor, since the main emphasis is on the individual characteristics of the patient:
- Hepa-Merz in the form of granules is intended for internal use. Before use, it is dissolved in water. It is best to use 200 ml of water for 1 sachet, however, the dosage of water does not have an actual effect on the effect of the medicine. Normal single dose - no more than 2 packets per 1 dose. It is taken immediately after meals 2-3 times a day. To prevent overeating and get rid of the consequences of alcohol abuse, in order to prevent the development of hepatic pathologies, you should take 1 sachet dissolved in water immediately after these events.
- Injection Hepa-Merz is intended for intravenous administration. For proper use, it is dissolved in half a liter of infusion fluid. On average, about 4 ampoules are used per dropper, however, in very serious situations, their number can increase to 8. Such droppers stretch for the whole day, since you should carefully monitor the rate of entry of Hepa-Merz and the infusion solution into the blood - their volume should not exceed 4 g per hour.
Use in breastfeeding and pregnancy
In general, the drug has no special contraindications. Including it is allowed to be used during pregnancy, but only under the strict attention of a doctor and with the knowledge that the risks from taking it are much less than from a possible refusal.
However, in general, clinical trials in pregnant women with its participation have not been used, so it would be best to refuse it if possible.
The same applies to the lactation period. However, when feeding, it would be better to completely abandon the drug, since it penetrates into the blood and milk that the child consumes. Ingestion of drug components into his body can lead to various consequences.
The use of the drug for violations of the functions of the renal and hepatic systems
Hepa-Merz is indicated for use in the treatment of numerous liver diseases. Its girth is truly striking in its breadth. However, renal failure is one of the contraindications, therefore, if it is present, the use of the drug should be completely abandoned.
Side effects and complications
The side effects of this drug are little studied due to their rarity.
They mainly focus on disorders in the gastrointestinal tract.
Patients after admission observed:
- severe nausea and vomiting;
- pain in the abdomen;
- diarrhea and persistent flatulence.
Pathological problems arising in the skeletal and muscular systems are even more rare, but pain in the arms and legs can sometimes manifest itself.
However, the most common complication is allergic reactions that affect the skin and form urticaria on the dermis.
Overdose
If the side effects begin to be pronounced, then this may indicate an overdose of Hepa-Mertz.
In such a situation, you should immediately stop using the drug and consult a doctor.
Standard treatment includes a full gastric lavage and detoxification of the body using conventional activated charcoal or another sorbent. All other symptoms are treated symptomatically.
Interaction with other drugs
At the moment, no clinical trials have been conducted to detect the interaction of Hepa-Merz with any other medicines, so there are no clear and structured data on this issue.
The influence of Hepa-Merz on the body when driving and operating mechanisms
Hepa-Merz does not have sedative qualities, so he is not able to dull the driver's reaction in any way. However, a number of liver diseases, such as encephalopathy, are dangerous in and of themselves, as they affect concentration and inhibit normal responsiveness to external distractions.
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drug interaction
Special tests for the relationship of Hepa-Merz with other drugs have not been conducted. However, doctors still do not advise taking it with a number of drugs.
These include:
special instructions
There are a number of rules that it is desirable to obey in order to achieve the best effect from taking Hepa-Merz:
- With the introduction of Hepa-Merz injections do not dissolve more than 6 ampoules in the infusion solution at once, otherwise the possibility of an overdose is high. Be sure to monitor the level of urea immediately in the blood and urine during this period. It is not allowed to enter into the arteries.
- The solution of the drug can not be administered in diabetes mellitus due to the presence of fructose, it is better to limit yourself to granulate.
- Prolonged use of Hepa-Merz has a strong effect on the teeth, increasing the rate of spread of caries.
- At the moment, there have been no cases of counterfeit Hepa-Merz. Authenticity can be traced to the series and appearance of the package and the drug. If in doubt, you should ask the pharmacy for a declaration of conformity, the pharmacist is obliged to provide the information of interest.
- Since Hepa-Merz allows the liver to work normally again, then the drug affects the performance of the liver - ALT and AST - it normalizes them to an optimal state.
Vacation from the pharmacy
To buy Hepa-Merz, a pharmacist does not need to present a special prescription, so it is freely available.
Storage conditions and shelf life
With proper storage: in a dark place where a child cannot reach it, in an intact shell at a temperature not exceeding 25 degrees, that is, at room temperature, Hepa-Merz will be usable for 60 months, or 5 years.
Price
Hepa-Merz can be bought at almost any pharmacy in the country, the price will depend on the package and the region of sale. The average price of 5 g ampoules is 2500 rubles for 10 pieces, sachets are much cheaper - 30 bags will cost 1600 rubles.
Analogues and synonyms of Hepa-Mertz
- Ornitsetil- analog medicine. The composition is the same as in Hepa-Merz, therefore the action and indications for use are equivalent. Out of production since 2008.
- Ornithine- a cheaper analogue, produced in granules, the active substance is ornithine. It has an effect on the liver, healing it. Price - from 400 rubles .
- Antraliv- a drug based on phospholepids at the same time helped to treat not only the liver, but also the biliary tract. It has not been produced in Russia since 2015.
- Berlition- helps to cope with the consequences of alcohol consumption and toxic liver diseases. Production closed in 2005.
- Brenciale forte- a hepatoprotector that allows you to heal not only the liver, but also treat psoriasis and accidental poisoning. Out of production since 2008.
- Vitanorm- mainly acts as a choleretic agent, helping to increase metabolism and correct urodynamics. Available in capsules - price from 450 rubles, homeopathic remedy.
- Gepabene- used to treat the liver after toxic exposure and during the course of radiotherapy and chemotherapy. Efficiency is provided by the extract of fumes and milk thistle. Price - from 410 rubles.
- Hepatosan– has a hepatoprotective effect and detoxifies the body. The active ingredient is porcine liver cells, fully compatible with the human body. Price - from 370 rubles.
- Hepatofalk planta- helps to treat diseases formed in the biliary tract, fights varicose veins in the esophagus. Has an antispasmodic effect. Out of production since 2006.
- Hepaphorus- is used not only to treat the liver, but also tuberculosis and poisoning. Their milk thistle capsules cost from 170 rubles.
- Heptor- helps to fight mainly with alcohol poisoning and medicines. It is used against depression and in diseases of the liver. Price - from 800 rubles .
- Heptral- hepatoprotector with antidepressant and antioxidant properties. Good in the fight against cirrhosis. Price - from 1500 rubles.
- Galstena- drops and tablets based on medicinal herbs - milk thistle and dandelion, completely homeopathic. Price - from 250 rubles .
- Sirepar- hepatoprotector based on vitamin B12 and livestock liver extract. Recommended for the first stages of cirrhosis and hepatitis, available as a liquid. Not sold in Russia due to lack of registration.
- Phosphogliv- capsules or lyophysilate help to cope with liver and skin diseases. Reacts well with corticosteroids. Price - about 500 rubles.
- Phosphogliv Forte- in addition to the hepatoprotective action, they improve immunity and help fight viral diseases. Price - from 900 rubles .
- Karsil- hepatoprotector in capsules based on milk thistle fruits. Works on the basis of silymarin, acting on toxins in the body. Price - from 330 rubles.
- Liv 52- an analogue of Karsil, helps to treat hepatitis and cirrhosis, is used in the fight against anorexia. Price - from 300 rubles.
- Rezalut pro- Phospholepid from Germany, helping to treat the liver. Analogue Essentiale Forte. Price - 450 rubles.
- Urdox- has a choleretic and hepatoprotective property, helps with cystic fibrosis and cholelithiasis. Price - from 650 rubles. Produced in Russia.
- Ursosan- helps to disperse bile, increase immunity and cope with liver damage. Price - from 189 rubles.
- Ursofalk- hepatoprotector based on ursodeoxycholic acid. Capsules help with cirrhosis and fibrosis. Price - about 2000 rubles.
- Essentiale N Soybean-based injections help increase the liver's resistance to disease, while improving its detoxification of the body. Price - 669 rubles.
- Essentiale Forte- used to treat hepatitis and other liver diseases, stones in the bile duct and as a prophylaxis in radiotherapy. Price - from 587 rubles.
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