Poor nutrition, side effects from taking medications, constant stress, the consequences of alcohol abuse - all this inevitably leads to the gastrointestinal tract. This condition is accompanied by unpleasant symptoms, leading to the development of diseases of the digestive system. In this case, Motilium tablets come to the rescue, the properties and indications for the use of which we will consider in this article.
Properties of the drug and general information
In case of poisoning and a strong gastrointestinal tract, both vomiting and vomiting can occur, so taking a medicine called Motilium will be an excellent treatment.Motilium refers to antiemetic drugs that have the property of blocking dopamine receptors. Due to the active ingredient domperidone, which is part of the drug, the drug improves gastrointestinal motility, therefore it is used in the treatment of many gastric pathologies.
Motilium is available in the form of a suspension, which is also called "Motilium syrup", as well as in the form of coated tablets and lozenges.
Instructions for use describe the following properties of Motilium:
- Suppresses the activity of the vomiting center in the brain;
- Increases in the esophagus;
- Increases the duration and intensity of contractions of the duodenum and stomach;
- Accelerates the evacuation of food lumps from the stomach into the duodenum.
Such properties determine the therapeutic effect of the drug - relief of symptoms of digestive disorders (belching, vomiting, nausea, feelings of heaviness, etc.) associated with gastric pathologies, in which food stagnates in the stomach.
Important! For patients suffering from gastric pathologies, Motilium is prescribed to relieve symptoms of the digestive system.
The substance domperidone stimulates the contractile activity of the gastric muscles, resulting in a rapid evacuation of food lumps into the duodenum. Food does not stagnate in the stomach and does not irritate it, so the unpleasant symptoms of dyspepsia quickly disappear in a person. Thus, Motilium helps to nullify the manifestations of stomach diseases, in which food stagnates (peptic ulcer, hypotension of the stomach, etc.).
In healthy people, symptoms of digestive functions can also be observed, such as malnutrition, overeating, alcohol abuse, etc. In this case, the drug helps to cope with the unpleasant sensations of fullness in the stomach.
By suppressing the vomiting center in the brain, Motilium eliminates vomiting, which can be caused by medication, an infectious disease, digestive disorders due to malnutrition, or other similar factors.
When is Motilium used?
Motilium is effective in combating symptoms such as vomiting, strong stomach, heaviness in the stomach and many others. Indications for use for all forms of release of Motilium (suspension, tablets) are the same:
- Relief of symptoms that occur with, reflux esophagitis, hypotension of the stomach, gastroesophageal:
- Vomit;
- Belching;
- Heartburn;
- Feelings of heaviness, fullness, arising after eating in the stomach.
- Vomiting and nausea caused by pathologies, infectious diseases or conditions that occur during motion sickness, improper diet, overeating.
- Vomiting and nausea resulting from taking certain medications, radiotherapy.
- Vomiting and nausea accompanying certain medical procedures (for example, the insertion of a gastric tube).
- Gastric motility disorders.
- Regurgitation syndrome in a newborn baby.
For kids
Indications for the use of Motilium in children are due to such conditions as difficult emptying, gastrointestinal, cyclic vomiting.
Important! Motilium quickly stops the unpleasant symptoms that occur when a baby is poisoned, contributes to the speedy recovery of disturbed processes and speeds up recovery.
Usually, the drug is prescribed for children in the form of a suspension, because. it is more convenient for a child to take.
During pregnancy
Motilium helps the expectant mother in the early and late stages of gestation to establish intestinal motility.
Motilium relieves unpleasant manifestations of preeclampsia and - nausea, vomiting, impaired motor function of the gastrointestinal tract.
In the postpartum period, Motilium can be prescribed according to the indications of doctors to stimulate the secretion of breast milk.
For nausea
Motilium instruction initially describes the drug as an antiemetic. To prevent nausea, the drug is best taken on an empty stomach or at least two hours before a meal.
When motion sickness, Motilium can be taken half an hour before the planned trip.
For heartburn
The sensation of heartburn occurs due to the accumulation of stomach contents in the esophagus. This condition can occur after suffering stress, due to malnutrition, alcohol abuse, obesity, and an unbalanced diet.
Motilium quickly relieves an unpleasant symptom, but will not be able to get rid of heartburn forever if you do not adjust nutrition and get rid of bad habits in parallel.
From diarrhea
It usually appears due to a malfunction in the functioning of the intestine due to bacterial infections or food poisoning.
Most often, babies who put objects that may be contaminated with salmonella into their mouths, as well as tourists who love to eat exotic food, suffer from it.
Motilium, which eliminates diarrhea in a short time, will help to improve the functioning of the intestines.
How to take Motilium
When taking pills, it is necessary to strictly follow the indicated daily dose, otherwise, in case of an overdose, the symptoms that were before will only intensify and others will be added to them. Motilium tablets are taken before meals - usually 15-30 minutes before. If necessary, the drug can also be drunk before bedtime.
The coated tablets are swallowed with plenty of water. Lozenges are placed under the tongue and wait until it turns into small particles, after which you can simply swallow them or drink about half a glass of water.
To relieve symptoms of dyspepsia the drug is taken according to the scheme - 1 tablet three times a day (for children over five years old and adults). If necessary, the dosage can be doubled (two tablets each), and such a dose can be given to children only from the age of 12.
For relief of nausea and vomiting appoint two tablets three to four times a day for adults and children over 12 years old. If the age is from 5 to 12 years, one tablet of the drug is also given three or four times a day.
Maximum daily dosage:
- ¼ tablet (2.4 mg) per kilogram of weight for the age of 5-12 years, but not more than 80 mg per day.
- No more than 8 tablets per day for adolescents over 12 years of age and adults.
- 2.5 ml per 10 kg of weight for children under 5 years of age (daily dose is calculated individually).
Note! For children under 5 years old and weighing less than 35 kg, Motilium is prohibited for use.
Exceeding the daily dose and prolonged uncontrolled use of the drug can provoke a state of overdose:
- Lethargy, weakness, drowsiness;
- Violation of motor activity;
- Excitation, changes in consciousness;
- Changes in muscle tone (muscle twitching or immobility in children).
If such symptoms appear, you should immediately consult a doctor who will prescribe the intake of sorbent and cleansing agents.
The use of Motilium is prohibited in the following diseases and conditions:
- Gastrointestinal;
- prolactinoma;
- Simultaneous use of drugs containing erythromycin, ketoconazole, clarithromycin, amiodarone, erythromycin, voriconazole, telithromycin;
- Mechanical obstruction of the intestine;
- Individual sensitivity to components;
- Mammary cancer;
- Perforation of any organ of the gastrointestinal tract.
In some cases, both types of Motilium tablets and suspension can cause side effects: Analogs and reviews 
The price of Motilium in tablets is about 400 rubles. for a pack of 10 pieces, and about 700 rubles. per pack of 30 tablets.
If there are contraindications for Motilium, or the person is not satisfied with how much the drug costs, cheaper substitutes can be used.
Analogues (from 40 to 180 rubles):
- Domperidone;
- Cerucal;
- Perinorm;
- Dimetpramide;
- cerulgan;
- Metoclopramide.
The use of Motilium in adults and children in most cases has positive reviews, but there are also ambiguous opinions, because. the drug has been used by people for various conditions and diseases.
So, when taking the drug to eliminate vomiting and nausea, 2/3 of the reviews note the immediate effect of the drug after the first pill taken. But 1/3 of patients noted long-term use of tablets, i.e. the result did not appear immediately, which caused people to leave negative comments.
When using Motilium for the relief of symptoms accompanying the pathology of the stomach and intestines, a rapid effect was observed, therefore reviews of Motilium in this case are almost 100% positive.
Any violation of the digestive system is a reason to see a doctor. It is not worth making a decision on taking Motilium on your own, especially when it comes to diseases of the digestive system.
This article is posted solely for the general educational purposes of visitors and is not scientific material, universal instructions or professional medical advice, and does not replace a doctor's appointment. For diagnosis and treatment, contact only qualified doctors.
For problems with the functioning of the gastrointestinal tract in children, doctors often prescribe Motilium in special pharmaceutical forms. The drug, indeed, quickly copes with problems, speeds up the recovery of the child and restores disturbed digestive activity.
Description of the drug and the composition of the release forms
Motilium for pediatric patients is prescribed in the form of tablets and in the form of a suspension. The active ingredient of the drug is domperidone, which has a pronounced antiemetic effect and stimulates intestinal motility.
Photo of Motilium in suspension for children
As additional components, Motilium contains: sodium hydroxide (purifies), polysorbate and sorbitol (choleretic and detoxifying agent). It also contains microcrystalline cellulose and water, sodium saccharinate, methyl and propyl parahydroxybenzoate.
Absorbable tablets can be taken by children older than 5 years of age, but on condition that the weight of the child is above 35 kg. In the form of a suspension or syrup, Motilium is prescribed to children from the first days of life.
Indications for use
The drug is prescribed to small patients only as prescribed by the pediatrician in accordance with the existing symptomatic appearances and the diagnosis. Usually, on the second day of using the drug, patients experience relief.
The main indications for the use of the drug are:
- Food intoxication and;
- Frequent regurgitation;
- any origin;
- and flatulence, excessive gas formation and heartburn, epigastric pain, etc.
In general, Motilium can be given to children when symptomatic manifestations occur, such as frequent constipation or, feelings of fullness in the stomach, painful or inflammation of the esophageal walls, inflammatory lesions in, or drug intoxication.
Dosage of Motilium suspension and tablets for children
The drug should be taken about 20-30 minutes before meals, then the therapeutic effect will be maximum.
- usually prescribed 1 pill 3 r / d;
- The suspension is given at a dosage of 2.5-5 ml per 10 kg of the baby's weight. If there is a slight disruption of the gastrointestinal tract, 2.5 ml / 10 kg is sufficient, and for acute disorders, it is already indicated to take 5 ml / 10 kg. In other words, in difficult clinical situations, the dosage of Motilium can be doubled.
In general, the duration of therapy should not exceed a 4-week course. But these are the deadlines for very serious conditions, more often a 3-4-day course of taking the drug is enough for the baby's condition to normalize.
In any situation, the timing of therapy should be individually determined by the pediatrician for each specific baby in accordance with his diagnosis and the severity of the disease. It is necessary to take the suspension from a special syringe attached to the drug.
The bottle must be shaken before use; for convenience, the attached syringe is already marked by the weight of the child.
When vomiting
The main therapeutic effect of the drug is the antiemetic effect. Therefore, at the first appearance of vomiting, it is recommended to give the baby a suspension according to the instructions. It is better to take on an empty stomach or a couple of hours before meals.
Diarrhea in a child
Contraindications
The drug when taken for children has certain contraindications:
- Hypersensitivity to sorbitol, domperidone and other components of the drug;
- The presence of severe;
- departments of the gastrointestinal tract;
- At ;
- Motilium is contraindicated in tumor pituitary formations;
- In case of suspicion of
Instructions for the use of a suspension of motilium for children with vomiting must be in the package of such a drug and are subject to careful study by the parents of the sick child. This drug is prescribed by the attending physician after examining the baby and identifying symptoms of poisoning or other conditions that are accompanied by nausea and vomiting.
In babies from birth, when taking any new food, there are disturbances in the work of the stomach and intestines due to the unstable functioning of the digestive system. To restore the normal functions of these important organs in infants and older, there are many drugs, and one of them is motilium.
Characteristics of the drug
The drug motilium is an antiemetic drug with domperidone as the active ingredient. The drug is designed to eliminate symptoms and restore the normal functioning of the stomach and upper intestine.
After taking the drug, it helps to raise pressure in the underlying part of the esophagus, increases the activity of the small and duodenal intestines and helps the stomach to get rid of processed food.
The active substance domperidone, with its therapeutic effect, does not affect the amount and acidity of the secreted gastric secretion.
Motilium in case of poisoning with medicine or food is an indispensable tool for relieving nausea and vomiting in children. Also, this drug helps with persistent motion sickness on the road, intoxication during viral, rotavirus and respiratory diseases.
Motilium, depending on the age of small patients, is available in different types and packages:
- Suspension in the form of a sweet whitish syrup in a 100 ml bottle. Complete with syrup in the package comes instructions and a syringe dispenser. The drug is prescribed for full-term infants from one month to five years. The amount of active substance domperidone is calculated in mg per kilogram of the child's weight.
- Mint flavored tablets in instant form. The drug is prescribed for preschool children from five to seven years old, weighing up to 25-30 kg. Complete with 10 or 30 tablets in the package comes instructions for the use of the drug.
- Tablets without taste in a dense shell. Medicines are prescribed for children of school age over seven years old, weighing more than 35 kg. In a package of 10 or 30 tablets, instructions for the correct use of the product are included.
Motilium in one form or another is prescribed only after consultation with a pediatrician, taking into account the condition, age and weight of the child.
Indications for taking the remedy
Motilium from nausea in a child can be prescribed to children of all ages, but in different forms, with such symptoms:
- air belching and regurgitation of breast milk;
- colic in the baby;
- vomiting with stable motion sickness on the road;
- diarrhea or frequent constipation;
- bloating in the abdomen;
- feeling of fullness in the stomach;
- spasms, accompanied by pain, in the upper abdomen;
- inadequate bowel function;
- the rise of undigested food or gastric juice into the esophagus or even into the oral cavity;
- inflammation of the walls of the esophagus;
- burning, turning into heartburn, in the stomach and in the lower region of the esophagus;
- overeating, accompanied by nausea and vomiting;
- food poisoning from stale food;
- inflammatory processes in the bile ducts;
- drug poisoning;
- nausea and vomiting in rotavirus disease.
Motilium with vomiting in a child should be taken only after the appointment of the attending physician in a dosage that was individually calculated by the doctor.
Contraindications
With all its advantages, motilium also has some contraindications:
- Intolerance to the active substance of domperidone or another constituent of the drug.
- Hypersensitivity to sorbitol included in the suspension.
- Severe liver disease.
- Ulcerative diseases of the stomach or intestines.
- Intestinal obstruction.
- Suspicion of bleeding in the stomach or intestines.
- Tumors in the pituitary gland.
- Simultaneous administration with amiodarone, voriconazole, clarithromycin, ketoconazole, telithromycin, fluconazole and erythromycin is prohibited.
Side effects
The use of motilium can be accompanied by a number of side effects:
- Spasmodic sensations in the stomach and intestines.
- Allergy in the form of itching, severe swelling of the hands, feet and face, urticaria, rashes all over the skin;
- Heartburn and dry throat, urinary retention.
- Decreased appetite.
- diarrhea or constipation;
- Ulcers on the oral mucosa.
- General conjunctivitis, occurring in the form of redness and swelling of the eyelids, pain and itching.
- General weakness and drowsiness.
- Headaches, restlessness and leg cramps.
- Inflammation in girls of the mammary gland.
According to laboratory studies, side effects from motilium appear in one baby in a hundred children. The use of motilac, as an analogue containing the same active substance domperidone, allows you to bypass some side effects.
In this article, you can read the instructions for using the drug Motilium. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Motilium in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Motilium in the presence of existing structural analogues. Use to treat nausea and vomiting in adults, children, and pregnancy and lactation.
Motilium- antiemetic, central blocker of dopamine receptors. Domperidone (the active substance of the drug Motilium) is a dopamine antagonist with antiemetic properties. Domperidone does not penetrate well through the blood-brain barrier. The use of domperidone is rarely accompanied by extrapyramidal side effects, especially in adults, but domperidone stimulates the release of prolactin from the pituitary gland. The antiemetic effect may be due to a combination of peripheral (gastrokinetic) action and antagonism to dopamine receptors in the chemoreceptor trigger zone. Animal studies and the low concentrations of the drug found in the brain indicate a central effect of domperidone on dopamine receptors.
When used orally, Motilium increases the duration of antral and duodenal contractions, increases pressure in the esophagus and accelerates gastric emptying in healthy people.
Domperidone has no effect on gastric secretion.
Pharmacokinetics
After ingestion on an empty stomach, Motilium is rapidly absorbed from the gastrointestinal tract. Although the bioavailability of domperidone is increased in healthy individuals when taken after meals, patients with gastrointestinal complaints should take domperidone 15-30 minutes before meals. Hypoacidity of gastric juice reduces the absorption of domperidone. When taken orally, domperidone does not accumulate and does not induce its own metabolism. Excretion in urine and feces is 31% and 66% of the oral dose, respectively. Excreted unchanged in feces (10%) and urine (approximately 1%).
Indications
A complex of dyspeptic symptoms often associated with
delayed gastric emptying, gastroesophageal reflux, esophagitis:
- a feeling of fullness in the epigastrium, early satiety, a feeling of bloating, pain in the upper abdomen;
- belching, flatulence;
- nausea, vomiting;
- heartburn, belching with or without gastric contents;
- nausea and vomiting of functional, organic, infectious origin caused by radiotherapy, drug therapy or dietary disturbances. A specific indication is nausea and vomiting caused by dopamine agonists when used in Parkinson's disease (such as levodopa and bromocriptine).
Release form
Film-coated tablets 10 mg.
Lozenges 10 mg.
Suspension or syrup for oral administration.
Instructions for use and dosing regimen
Adults and adolescents over 12 years of age are prescribed 1-2 tablets 3 or 4 times a day, the maximum daily dose is 80 mg.
Children are prescribed 1 tablet 3-4 times a day. In the absence of the desired effect, the indicated dose can be doubled. The maximum daily dose is 80 mg.
Motilium tablets are indicated only for adults and children weighing more than 35 kg; in pediatric practice, Motilium suspension should be used.
Lozenges
In chronic dyspepsia, adults and children over 5 years of age are prescribed 10 mg (1 tablet) 3 times a day 15-30 minutes before meals and, if necessary, at bedtime.
The maximum daily dose for children aged 5 to 12 years is 2.4 mg / kg body weight, but not more than 80 mg.
If necessary, in the absence of effect, for adults and children over the age of 12 years, a single dose can be doubled. The maximum daily dose is 80 mg.
For nausea and vomiting, adults and children over 12 years of age are prescribed 20 mg (2 tablets) 3-4 times a day before meals and at bedtime. The maximum daily dose is 80 mg.
Children aged 5 to 12 years are prescribed 10 mg (1 tablet) 3-4 times a day before meals and at bedtime. The maximum daily dose is 2.4 mg / kg of body weight, but not more than 80 mg.
Motilium in the form of lozenges is indicated only for adults and children weighing more than 35 kg.
Rules for the use of lozenges
Lozenges are available in blister packs. Since the tablets are quite fragile, they should not be forced through the foil to avoid damage.
In order to get a tablet out of the blister, take the foil by the edge and completely remove it from the cell in which the tablet is located. Then gently press down and remove the tablet from the package. The tablet should be put on the tongue. Within a few seconds, it will disintegrate on the surface of the tongue and can be swallowed with saliva without drinking water.
Adults and adolescents over 12 years of age and weighing more than 35 kg are prescribed 10-20 ml of suspension 3 or 4 times a day, the maximum daily dose is 80 ml.
Children, incl. infants are prescribed 0.25-0.5 mg of domperidone (0.25-0.5 ml of suspension) per 1 kg of body weight 3 or 4 times a day. The maximum daily dose is 2.4 mg per 1 kg of body weight, but not more than 80 mg per day. To determine the dose, use the child's body weight scale "0-20 kg" on the syringe.
Suspension application rules
Shake the suspension vial before use. The suspension is supplied in a package protected from accidental opening by children. The vial should be opened in the following way: press down on the plastic cap of the vial while turning it counterclockwise; remove the screwed cover.
Then the syringe should be placed in the vial. While holding the lower ring in place, raise the upper ring to the mark corresponding to the child's body weight (kg). Holding the bottom ring, pull the filled syringe out of the vial. Empty the syringe. Close the vial. Rinse the syringe with water.
Side effect
- gastrointestinal disorders;
- transient spasms of the intestines;
- convulsions;
- drowsiness;
- headache;
- nervousness;
- anaphylactic reactions, including anaphylactic shock;
- angioedema;
- allergic reactions;
- hives;
- galactorrhea;
- gynecomastia;
- amenorrhea;
- rash.
Contraindications
- prolactin-secreting pituitary tumor (prolactinoma);
- concomitant use of oral forms of ketoconazole, erythromycin or other strong inhibitors of the CYP3A4 isoenzyme, causing a prolongation of the QTc interval, such as fluconazole, voriconazole, clarithromycin, amiodarone and telithromycin;
- gastrointestinal bleeding, mechanical obstruction or perforation of the gastrointestinal tract, in which stimulation of the motor function of the stomach may be dangerous;
- body weight less than 35 kg;
- established intolerance to the drug and its components.
Use during pregnancy and lactation
There are insufficient data on the use of Motilium during pregnancy.
To date, there is no evidence of an increased risk of malformations in humans. However, Motilium should only be used during pregnancy if the expected benefit to the mother outweighs the potential risk to the fetus.
In women, the concentration of domperidone in breast milk ranges from 10 to 50% of the corresponding plasma concentration and does not exceed 10 ng / ml. The total amount of domperidone excreted in breast milk is less than 7 mcg per day, when using the maximum allowable doses. It is not known whether this level has a negative effect on infants. Therefore, when using Motilium during lactation, breastfeeding should be discontinued.
special instructions
With the combined use of the drug Motilium with antacids or antisecretory drugs, the latter should be taken after meals, and not before meals, i.e. they should not be taken concomitantly with Motilium.
The film-coated tablets contain lactose and should therefore not be used in patients with lactose intolerance, galactosemia and malabsorption of glucose and galactose.
Given the high degree of metabolism of domperidone in the liver, Motilium should be used with caution in liver failure.
Since a very small percentage of the drug is excreted by the kidneys unchanged, adjustment of a single dose in patients with renal insufficiency is not required. However, upon re-appointment, the frequency of administration should be reduced to 1 or 2 times a day, depending on the severity of the insufficiency, and it may also be necessary to reduce the dose.
With long-term therapy, patients should be monitored regularly.
Pediatric use
Motilium in rare cases can cause neurological side effects. In this regard, you should strictly adhere to the recommended dose. Neurological adverse effects may be caused in children by an overdose of the drug, but other possible causes of such effects must be taken into account.
Influence on the ability to drive vehicles and control mechanisms
Motilium has no or negligible effect on the ability to drive and operate machinery.
drug interaction
Anticholinergic drugs can neutralize the effect of the drug Motilium.
The bioavailability of the drug Motilium when taken orally decreases after the previous intake of cimetidine or sodium bicarbonate. You should not take antacids and antisecretory drugs at the same time as domperidone, because. they reduce its bioavailability after oral administration.
The main role in the metabolism of domperidone is played by the CYP3A4 isoenzyme. The results of in vitro studies and clinical experience show that the simultaneous use of drugs that significantly inhibit this isoenzyme can cause an increase in plasma concentrations of domperidone. Strong inhibitors of CYP3A4 include: azole antifungals such as fluconazole, itraconazole, ketoconazole, and voriconazole; macrolide antibiotics such as clarithromycin and erythromycin; HIV protease inhibitors, eg amprenavir, atazanavir, fosamprenavir, indinavir, nelfinavir, ritonavir and saquinavir; calcium antagonists such as diltiazem and verapamil; amiodarone; aprepitant; nefazodon; telithromycin. (Drugs marked with an asterisk also prolong the QTc interval.)
In a number of studies of pharmacokinetic and pharmacodynamic interactions of domperidone with oral ketoconazole and oral erythromycin in healthy volunteers, these drugs have been shown to significantly inhibit the primary metabolism of domperidone, carried out by the CYP3A4 isoenzyme.
At present, it is not known what contribution to the change in the QTc interval is made by elevated plasma concentrations of domperidone.
Theoretically (because the drug has a gastrokinetic effect), Motilium could affect the absorption of concomitant oral drugs, in particular, drugs with a slow release of the active substance or enteric-coated drugs. However, the use of domperidone in patients receiving paracetamol or digoxin did not affect the level of these drugs in the blood.
Motilium can be taken simultaneously with antipsychotics, the action of which it does not enhance; dopamine receptor agonists (bromocriptine, levodopa), whose undesirable peripheral effects, such as digestive disorders, nausea, vomiting, it suppresses without affecting their central effects.
Analogues of the drug Motilium
Structural analogues for the active substance:
- Damelium;
- Domet;
- Domperidone;
- Domperidone GEXAL;
- Domperidone-Teva;
- Domstal;
- Motijekt;
- Motilac;
- Motinorm;
- Motonium;
- Passagex.
In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.
Thank you
The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!
Motilium represents antiemetic, which also has the ability to reduce the severity of dyspeptic symptoms (heartburn, flatulence, belching, nausea, vomiting, feeling of fullness and pain in the stomach after eating, etc.) due to impaired evacuation of the food bolus from the stomach to the intestines. Therefore, Motilium is used to stop vomiting, as well as alleviate dyspeptic symptoms in reflux esophagitis, gastroesophageal reflux, GERD, esophagitis, gastric hypotension, as well as against the background of cytostatic therapy or radiotherapy of tumors.Release forms, names and composition of Motilium
Motilium is currently available in the following three dosage forms:1. Tablets for resorption in the oral cavity;
2. Coated tablets for oral administration;
3. Suspension for oral administration.
Coated and oral lozenges are usually referred to simply as "Motilium tablets" without specifying which variety is being referred to. And the suspension is often called Motilium syrup in everyday speech. However, since Motilium does not exist in the form of a syrup, people use this term to refer to the liquid form of the drug, without going into the subtleties of the differences between suspension, solution, syrup, emulsion, etc. In addition, the suspension is often called children's Motilium, since it is this dosage form that is used in pediatric practice.
The composition of all dosage forms of Motilium as an active substance includes domperidone in the following different dosages:
- Tablets for resorption in the oral cavity - 10 mg;
- Tablets for oral administration in the shell - 10 mg;
- Suspension - 1 mg per 1 ml.
| Lozenges | Coated tablets | Suspension |
| Gelatin | Lactose | Saccharin sodium |
| Mannitol | Corn starch | Sorbitol |
| aspartame | Potato starch | Sodium hydroxide |
| mint essence | Polividon | Polysorbate |
| Poloxamer 188 | Microcrystalline cellulose | |
| magnesium stearate | Purified water | |
| Hydrogenated vegetable oil | Sodium carboxymethylcellulose | |
| Lauryl sulfate | Methyl parahydroxybenzoate | |
| Hypromellose | Propyl parahydroxybenzoate |
The lozenges are round in shape and white or almost white in color. Coated tablets are round, white or off-white in color and marked "Janssen" and "M/10" on the flat surfaces. If the tablet in the shell is broken, then at the break it will be uniformly white, without inclusions. Both types of tablets are available in packs of 10 or 30 pieces.
The suspension is a white opaque liquid of a homogeneous structure and jelly-like consistency. Produced in dark glass bottles of 100 ml.
What helps Motilium (therapeutic effects)
Motilium has the following pharmacological effects: - Suppression of the activity of the vomiting center in the brain;
- Increase in the intensity and duration of contractions of the stomach and duodenum;
- Increased pressure in the esophagus;
- Acceleration of the evacuation of the food bolus from the stomach into the duodenum.
Motilium improves the contractile activity of the stomach muscles, which leads to a faster evacuation of the food bolus into the duodenum. And due to the fact that food does not stagnate and does not irritate the stomach, a person experiences painful symptoms of dyspepsia (belching, heartburn, flatulence, etc.). That is, Motilium helps to get rid of the symptoms of stomach diseases, in which food stagnates in it. And since these symptoms can also occur in a healthy person, for example, when overeating, eating fatty or unusual foods, or with other violations of a normal balanced diet, Motilium will also help in this case to get rid of the discomfort associated with stomach overcrowding.
Due to the increase in pressure in the esophagus, Motilium prevents gastroesophageal reflux, reducing heartburn and other symptoms (sour belching, etc.), as well as helping to cure GERD (gastroesophageal reflux disease). That is, Motilium helps to stop the symptoms of gastroesophageal reflux and GERD.
And due to the suppression of the activity of the vomiting center, Motilium is able to eliminate vomiting provoked by an infectious disease, taking medications, various chronic pathologies of any organs and systems, as well as functional digestive disorders caused by the use of unknown or unusual food and other similar factors.
Motilium - indications for use
Suspension and both types of Motilium tablets are indicated for use in the following identical cases:1. Relief of the following symptoms of hypotension of the stomach, gastritis, GERD, reflux esophagitis, gastroesophageal reflux arising from food retention in the stomach and its slow evacuation into the intestines:
- Feeling of heaviness, pressure or fullness in the stomach after eating;
- Pain in the stomach after eating;
- Bloating
- Belching, including sour contents;
- Vomit;
- Heartburn;
- Regurgitation (throwing a fairly large amount of stomach contents into the oral cavity).
3. Nausea and vomiting provoked by drugs, as well as radiotherapy and chemotherapy for tumors.
4.
Nausea and vomiting provoked by taking Levodopa, Bromocriptine or other drugs of the dopamine agonist group in parkinsonism.
5.
Relief of nausea and gag reflex during medical procedures, for example, the introduction of a gastric tube, the production of EFGDS, etc.
6.
regurgitation syndrome in children.
7.
Cyclic vomiting in children.
8.
Gastroesophageal reflux in children.
9.
Disorders of gastric motility in children.
Instructions for use
Consider the rules for using both types of Motilium tablets in one section, since they differ slightly. And we will consider the rules for using Motilium suspension in a separate section.Motilium tablets - instructions for use
The absorbable and coated tablets should be taken 15 to 30 minutes before a meal. Also, if necessary, Motilium can be taken at bedtime. The coated tablet is simply swallowed without biting or chewing with half a glass of water. A lozenge is placed on the tongue and wait a few seconds until it breaks up into small particles. After that, the formed particles are swallowed and, if necessary, washed down with a few sips of water. However, if for some reason there is no water, then absorbable tablets can not be washed down after they have disintegrated into small particles on the tongue and have been swallowed.
The coated tablets can be removed from the blister without any special precautions. And with absorbable tablets, care must be taken, as they are quite fragile. In order to avoid breaking and spilling the tablets, it is recommended not to squeeze them out of the blister through the foil, but to carefully cut the edge of the cell with scissors. You can also carefully remove the foil from one cell and remove the tablet from it.
To stop the manifestations of dyspepsia (belching, heartburn, flatulence, feeling of fullness in the stomach, etc.) in chronic diseases of the stomach and esophagus, adults and children over 5 years old should take 1 tablet 3 times a day before meals, and, if necessary, before sleep. If there is no effect, children over 12 years of age and adults can double the dosage, that is, take 2 tablets 3 times a day before meals.
With nausea and vomiting for their relief, children over 12 years of age and adults should take 2 tablets 3 to 4 times a day before meals and at bedtime. And for children 5-12 years old, for the relief of nausea and vomiting, 1 tablet 3-4 times a day before meals and at bedtime should be given.
For children 5-12 years old, the maximum allowable daily dosage of Motilium is 2.4 mg (1/4 tablet) per 1 kg of body weight, but not more than 80 mg (8 tablets). For adults and adolescents over 12 years of age, the maximum allowable daily dosage of Motilium is 80 mg.
For children under 5 years of age, the drug is given in the form of a suspension and the dosage is calculated individually according to body weight, based on the ratio of 2.5 ml per 10 kg of weight. Motilium tablets are not used in children under 5 years of age and weighing less than 35 kg.
Motilium suspension (Motilium for children) - instructions for use
The suspension is intended for use in children under 5 years of age and weighing less than 35 kg. In children of the first year of life, the drug should be used only as directed by a doctor and under constant supervision. Suspension, as well as tablets, should be given to the child 15 to 30 minutes before meals and, if necessary, at bedtime. The amount of the drug, measured with a special syringe, must be poured into a spoon or into a small container (glass, glass, etc.) and given to the child to drink. You can drink the suspension as you wish.
The dosage of the suspension for use for various conditions in children is the same and depends only on body weight. The dosage each time is calculated individually according to the ratio of 0.25 - 0.5 ml of suspension for every 1 kg of the child's body weight. The calculated amount of suspension is given to the child 3-4 times a day before meals and, if necessary, at bedtime.
However, since a convenient measuring syringe is supplied with the bottle, which simultaneously indicates the child's weight in increments of 1 kg and the corresponding amount of suspension in ml, you can not calculate the dosage for the baby. Simply use the included measuring syringe.
The maximum allowable daily dosage of Motilium suspension for children under 5 years of age is 2.4 ml per 1 kg of body weight, but not more than 80 mg (80 ml of suspension).
If necessary, the suspension can be taken by both adults and adolescents over 12 years of age at a dosage of 10-20 ml 3-4 times a day. The maximum allowable daily dose of the suspension for adults and adolescents over 12 years of age is 80 ml.
Each time before use, shake the vial with the suspension, and then open it according to the following algorithm:
1.
Press on the cover from above while turning it counterclockwise;
2.
Remove cover;
3.
Remove the measuring syringe from the package and lower it into the vial so that its tip goes into the suspension by 1-3 cm;
4.
Holding the lower ring of the syringe with your fingers, raise the piston to a mark that corresponds to the weight of the child;
5.
Holding the syringe by the lower ring, remove it from the vial;
6.
Squeeze the suspension into a spoon or other container;
7.
Rinse the syringe well with warm water after use;
8.
Close the vial.
special instructions
Do not use Motilium for the relief and prevention of postoperative vomiting.In renal insufficiency, it is recommended to maximize the intervals between two subsequent doses of the drug, but the dosage is not required to be reduced. However, if a person suffering from renal insufficiency must take Motilium for a long time, then the entire daily dosage should be divided into 1-2 doses, and not 3-4. If the kidney function worsens during the use of the drug, then it is necessary to reduce the dosage of the drug.
In case of liver failure, the drug in any form should be used with caution, constantly monitoring the functions and condition of the liver.
When using Motilium simultaneously with antacids (Renny, Phosphalugel, Almagel, Maalox, etc.) and H2-histamine blockers (Ranitidine, Famotidine, etc.), their intake should be spaced in time. It is optimal to take Motilium before meals, and antacids and H2-histamine blockers - after meals.
The coated tablets contain lactose, so they should not be taken by people suffering from milk sugar intolerance, as well as malabsorption of glucose and galactose. Also, lozenges should not be taken by people who have an increased risk of developing hyperphenylalaninemia due to their aspartame content.
In children under 1 year of age, Motilium in rare cases can provoke neurological side effects, therefore, when using the drug, one should strictly adhere to the recommended dosages, without increasing them on their own.
Use during pregnancy and breastfeeding
During pregnancy, Motilium can only be taken if the intended benefit to the mother outweighs the possible risks to the fetus. When breastfeeding, Motilium should not be taken, since the drug is in milk at a concentration of 50% of that in the blood. Influence on the ability to control mechanisms
Motilium does not affect a person's ability to control mechanisms, therefore, against the background of the use of the drug, you can engage in any type of activity that requires a high concentration of attention and speed of reactions.Overdose
An overdose of Motilium is possible and is manifested by the following symptoms:- Disorientation;
- Agitation (excitement);
- Altered consciousness;
- Extrapyramidal reactions (tremor, speech disorder, tics, myoclonus, etc.).
Interaction with other drugs
Reduce the severity of the therapeutic effect of Motilium anticholinergics (Aprofen, Atropine, Scopolamine, Dicyclomine, Cyclizine, Benaktizin, etc.), Cimetidine and sodium bicarbonate. Enhance the action of Motilium Fluconazole, Itraconazole, Ketoconazole, Coriconazole, Clarithromycin, Erythromycin, Amprenavir, Atazanavir, Fosamprenavir, Indinavir, Nelfinavir, Ritonavir, Saquinavir, Diltiazem, Verapamil, Amiodarone, Aprepitant, Nefazodone and Telithromycin.Ketoconazole and Erythromycin, when used simultaneously with Motilium, cause ECG changes that normalize after discontinuation of the drugs.
Side effects of Motilium
Suspension and both varieties of Motilium tablets can cause the same following side effects from various organs and systems: 1. Gastrointestinal tract:
- Spasms of the intestines;
- Changes in the activity of AsAT, AlAT and alkaline phosphatase;
- Thirst;
- Appetite disturbance.
- Extrapyramidal syndrome (tics, tremor, speech disorder, parkinson-like movements, muscle tone disorders, etc.);
- convulsions;
- Drowsiness;
- Agitation (excitement);
- Anaphylactic reactions (Quincke's edema, anaphylactic shock, urticaria);
- Allergic reactions.
- An increase in the level of prolactin in the blood;
- Galactorrhea (leakage of milk from the breast);
Extrapyramidal disorders, as a rule, occur in children, but are transient, that is, they disappear on their own after the end of Motilium intake and do not require special treatment.
Contraindications for use
Suspension and both varieties of Motilium tablets are contraindicated for use if a person has the following diseases or conditions:- Prolactinoma (a tumor of the pituitary gland of the brain that produces prolactin);
- Hyperprolactinemia (increased levels of prolactin in the blood);
- Simultaneous administration of drugs containing ketoconazole, erythromycin, fluconazole, voriconazole, clarithromycin, amiodarone or telithromycin as active substances;
- Gastrointestinal bleeding;
- Mechanical obstruction of the intestine;
- Perforation of any organ of the digestive tract;
- Body weight less than 35 kg (for tablets);
- Individual sensitivity or intolerance to the components of the drug;
- Pregnancy and lactation.
Motilium - analogues
On the pharmaceutical market, Motilium has analogues and synonyms. Synonyms are products containing, like Motilium, domperidone as an active substance. Analogues are medicines containing other active substances, but having the most similar spectrum of therapeutic action.Synonyms of Motilium are the following drugs:
- Damelium tablets;
- Domet tablets;
- Domperidone, Domperidone Geksal and Domperidone-Teva tablets;
- Domstal tablets;
- Motiject tablets;
- Motilac lozenges and film-coated tablets;
- Motinorm syrup and tablets;
- Motonium tablets;
- Passagex tablets are chewable and coated.
- Aceclidine solution for subcutaneous injection;
- Ganaton tablets;
- Dimetpramide tablets and solution for intramuscular injections;
- Itomed tablets;
- Itopra tablets;
- Melomide hydrochloride tablets and solution for intravenous and intramuscular injections;
- Metoclopramide tablets and solution for intravenous and intramuscular injections;
- metoclopramide-acry tablets;
- Metoclopramide-Vial, Metoclopramide-Promed, Metoclopramide-ESCOM solution for intravenous and intramuscular injections;
- Perinorm tablets, oral solution and solution for intravenous and intramuscular injections;
- Ceruglan tablets and solution for intravenous and intramuscular injections;
- Cerucal tablets and solution for intravenous and intramuscular injections.
Cheap analogues
Among the synonyms of Motilium, the cheapest drugs are the following:- Domet - 76 - 108 rubles;
- Domperidone - 99 - 113 rubles;
- Passazhiks - 84 - 107 rubles;
- Motilak - 126 - 232 rubles;
- Motonium - 94 - 100 rubles.
- Dimetpramide - 89 - 168 rubles;
- Metoclopramide 35 - 135 rubles;
- Perinorm 99 - 183 rubles;
- Tseruglan 19 - 42 rubles;
- Cerucal 125 - 142 rubles.
Russian analogues of Motilium
Synonyms and analogues of Motilium produced by Russian pharmaceutical plants are shown in the table.Reviews
Reviews on the use of Motilium in adults in most cases are positive, due to the high effectiveness of the drug when taken according to indications. However, in the reviews, not everything is unambiguous and there are a large number of nuances, since the range of conditions under which people took Motilium is quite wide and varied. So, adults took Motilium in two main cases. First, the drug was taken occasionally to relieve nausea and vomiting that arose due to existing diseases of the digestive tract, dietary disorders, or an infectious disease. Secondly, adults took Motilium as part of the complex therapy of stomach diseases (gastritis, peptic ulcer, pyloric stenosis, etc.), reflux and GERD in order to relieve flatulence, a feeling of fullness in the epigastrium, belching, early satiety, vomiting and other symptoms of the disorder. digestion of food, characteristic of these diseases.
With occasional use of Motilium to stop vomiting and nausea, the drug eliminates these symptoms in about 2/3 cases after the first pill. Stopping vomiting and nausea significantly improves a person’s general well-being, allowing him to calmly drink various solutions to replenish fluid loss, as well as take other medications, the action of which is aimed at eliminating the cause of symptoms and treating the disease. In such situations, reviews of Motilium were positive.
In the remaining 1/3 of cases, people had to take Motilium to stop vomiting for several days in a row before each meal or liquid. This mode of using the drug, of course, does not please people, therefore, in such situations, as a rule, they leave a neutral or negative review.
And when taking Motilium to relieve dyspeptic symptoms (belching, nausea, vomiting, flatulence, feeling of stomach fullness, epigastric pain, etc.), characteristic of chronic stomach diseases, GERD and reflux, the drug was effective in almost 100% of cases, Therefore, this category of reviews about him is almost all positive.
Motilium for children - reviews
Currently, there is a very interesting situation when, in practice, Motilium is used in children for a wide range of different conditions, and very often not according to indications, but according to their own ideas about the physiological functions of the child's body. Naturally, in such a situation, reviews of Motilium are very diverse. To navigate them, consider the reviews of people who gave the drug to a child for various reasons.Reviews on the use of Motilium for the relief of vomiting in children with rotavirus infections, any other acute infectious diseases, as well as in response to medication in about 2/3 of cases, are positive. This is due to the fact that the drug stopped vomiting and improved the general condition of the child, who began to actively play, ask for drink, eat, etc. Moreover, in some cases, a single dose of the drug was enough to stop vomiting, and in others, it was necessary to give the child syrup several times a day for 2 to 3 days. When vomiting did not stop after a single dose of the drug, then the parents gave Motilium to the child before each meal, drink or other medication.
Approximately 1/3 - 1/4 reviews of Motilium for the relief of vomiting in acute conditions in children are negative, which, as a rule, is due not so much to the properties of the drug as to a subjective attitude towards it, high expectations, and also use not according to indications. Very often, parents try to give their child Motilium with vomiting provoked by poisoning, and when the drug does not have the expected effect, they are disappointed and leave negative feedback. In fact, Motilium will not stop vomiting in case of poisoning, since it is due to the entry of toxic substances into the blood from the intestine, and not a disorder of the stomach. In such cases, you need to take sorbents that bind toxic substances. And Motilium can be drunk only before taking the sorbent, so that the child does not vomit within the next 10-15 minutes and the main therapeutic drug is not brought out.
The second part of the reviews about Motilium concerns its use in infants and young children in order to reduce gas formation, bloating and regurgitation. In this case, almost all reviews of the drug are positive, since the syrup effectively stopped these symptoms.
The third part of the reviews about the drug concerns its use in diseases of the digestive tract in children (GERD, gastritis, gastroduodenitis, esophagitis, reflux) in order to relieve the unpleasant symptoms of slow gastric emptying (feelings of heaviness in the stomach, abdominal pain, belching, flatulence, nausea, vomiting and etc.). This category of reviews is in most cases positive, since parents achieve a good therapeutic effect with regular use of Motilium syrup according to the instructions.
The fourth part of the reviews about Motilium concerns its use not according to indications. So, many parents give syrup to children so that the food from the stomach is evacuated faster, and they can eat more at a time. This use of syrup is based on the fact that Motilium stops the feeling of fullness in the stomach. Usually, the drug is used in this way when trying to make the child "eat well" and gain weight, which, according to parents and doctors, is insufficient. Naturally, such a method of improving the child's appetite and increasing the amount of food he eats does not work for a number of reasons, and parents leave a negative review about the drug.
Firstly, Motilium reduces the feeling of fullness in the stomach and accelerates the passage of the food bolus into the intestines only in diseases such as peptic ulcer, gastritis, GERD, esophagitis and reflux! And if the child does not suffer from such diseases, then his food is evacuated from the stomach to the intestines at a normal rate, and attempts to reduce this period of time only lead to the fact that the food bolus is poorly processed and digested by gastric juice. This will cause the baby colic, flatulence, bloating and other discomfort. In other words, by trying to speed up the evacuation of the food bolus from the stomach to the intestines in order to “make room” for another large portion of food, parents only disrupt the normal process of digestion in a child, which can ultimately cause the development of severe chronic diseases of the gastrointestinal tract.
Secondly, while taking Motilium, the child will not be able to eat more, but, on the contrary, will be saturated with a smaller amount of food. This is due to the fact that the food bolus will quickly enter the intestines, from where the nutrients will begin to be absorbed into the bloodstream and give a signal to the brain about the onset of satiety. As a result, the child will be satisfied with much less food than before.
That is, the use of Motilium in order to "improve" the child's nutrition is not only irrational, inexpedient, ineffective and not according to indications, but also dangerous. In order for the child to gain weight, you need to feed him small portions of high-calorie and tasty food 4 to 6 times a day. And trying to feed him a large portion of low-calorie food only stretches the stomach, disrupts the normal process of digestion and creates the basis for the development of gastrointestinal diseases.
Ganaton or Motilium?
Ganaton is a prokinetic drug, that is, it improves the motor function of the stomach, accelerating the evacuation of its contents and, thereby, stopping the painful symptoms associated with food retention in it (heartburn, belching, flatulence, feeling of fullness and pain in the stomach, etc. .). And Motilium can be used for the same conditions as Ganaton, but also for stopping vomiting. That is, the spectrum of indications of Motilium overlaps that of Ganaton. However, the effectiveness of Ganaton is 10% higher compared to Motilium. This means that for the relief of painful symptoms (nausea, vomiting, heartburn, belching, feeling of fullness and pain in the epigastrium, etc.) of diseases of the stomach and esophagus (gastritis, esophagitis, GERD, peptic ulcer, etc.), both Ganaton and and Motilium. However, Ganaton is preferable in such situations, since this drug is intended specifically for use in the complex therapy of these conditions.
Ganaton is also preferable in cases where it is necessary to take drugs for a long period of time or in conjunction with other drugs. This is usually necessary in the treatment of chronic diseases of the stomach and esophagus.
For episodic relief of symptoms of dyspepsia (heartburn, belching, vomiting, nausea, a feeling of fullness in the stomach, epigastric pain after eating, etc.) arising from a violation of the diet or for other reasons, you can use any drug that, for any reasons people like it more.
To stop vomiting and nausea caused by taking any medications, infections, gastrointestinal diseases and functional digestive disorders, Motilium should be chosen, since Ganaton is ineffective in such situations.
Motilium should also be chosen if it is necessary to use drugs with similar properties in children, since Ganaton cannot be used to treat babies.
Motilium or Motilac?
Motilium and Motilac are synonyms, that is, they contain exactly the same active ingredient domperidone. In terms of therapeutic effects, Motilac and Motilium do not differ from each other, however, the first drug causes side effects more often.Thus, in the absence of any special requirements for the drug, as well as with overall good drug tolerance, when side effects are rare, you can choose any remedy - Motilak or Motilium, based only on subjective preferences (for example, for some reason like one drug more than another, relatives or friends respond positively). If a person is prone to the development of side effects or does not tolerate any medication, then Motilium should be preferred.
However, Motilium is available in tablets and suspensions, while Motilac is available only in tablets. Therefore, Motilac cannot be used for children, but Motilium can. That is, if it is necessary to use the remedy in children or in people who for some reason find it difficult to swallow tablets, Motilium should be preferred. If a person can take pills, then you can choose any remedy based on your own subjective preferences.
Motilium (tablets and suspension) - price
The cost of various dosage forms of Motilium varies in pharmacies of Russian cities within the following limits:- Suspension 1 mg / ml, bottle 100 ml - 485 - 672 rubles;
- Lozenges 10 mg, 10 pieces - 345 - 458 rubles;
- Lozenges 10 mg, 30 pieces - 550 - 701 rubles;
- Coated tablets 10 mg, 30 pieces - 452 - 589 rubles.
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