Registration number: ЛС-002159-020916
Trade name. Bifidumbacterin
Grouping name. Bifidobacterium bifidum
Dosage form. Lyophilisate for preparation of suspension for oral administration and topical application
Composition (1 dose):
Active substance: from 1x10 ^ 7 to 5x10 ^ 7 live bifidobacteria or more than 5x10 ^ 7 live bifidobacteria
Excipients: components of a protective drying medium * (gelatin; sucrose (sugar); milk)
* The content of the components of the protective drying medium in the finished product is not determined
Description. Crystalline or porous mass of various shades of beige, light brown or whitish gray with a specific odor.
The drug is a microbial mass of live antagonistically active strains of bifidobacteria (Bifidobacterium bifidum 1 or Bifidobacterium bifidum 791), lyophilized in a cultivation medium with the addition of a protective sucrose-gelatin-milk drying medium
Pharmacotherapeutic group. Eubiotic.
ATX code: A07FA
Pharmacological properties. The therapeutic effect of Bifidumbacterin is due to the content of live bifidobacteria in it, which have antagonistic activity against a wide range of pathogenic and opportunistic microorganisms and thereby normalize the intestinal microflora, improve the activity of the gastrointestinal tract, and prevent the formation of protracted forms of intestinal diseases.
Indications for use.
Treatment and prevention of dysbacteriosis of various etiologies in children and adults. For children (including premature babies), the drug can be used from the first days of life.
For diseases of the gastrointestinal tract:
- long-term intestinal dysfunction of unknown etiology;
- acute intestinal infections (in the complex treatment of acute dysentery, salmonellosis, escherichiosis, viral diarrhea, etc.), prolonged intestinal dysfunction of staphylococcal etiology, as well as the treatment of convalescents after acute intestinal infections with continuing intestinal dysfunction;
- in the complex treatment of children (including newborns, premature babies), patients with pneumonia, sepsis and other purulent-infectious diseases, for the prevention or relief of intestinal dysfunction and prevention of the development of necrotizing ulcerative enterocolitis;
- children with aggravated premorbid condition: born prematurely or with signs of prematurity, receiving antibiotics in the early neonatal period; children whose mothers suffered from severe toxicosis, extragenital diseases, had a long anhydrous period or other pathology; children of mothers with lactostasis, cracked nipples and resuming breastfeeding after recovery from mastitis; weakened children with anemia, malnutrition, rickets, diathesis and other manifestations of allergies; with whooping cough, especially if they have any disorders of bowel function;
- with early transfer of infants to artificial feeding;
- acute and chronic inflammatory diseases of the large and small intestine (colitis, enterocolitis) in older children and adults, occurring against the background of microflora disorders with a deficiency or absence of bifidoflora;
- intestinal dysfunctions as a result of intestinal dysbiosis, which arose as a result of prolonged antibacterial, hormonal, radiation and other therapy, in stressful situations and in extreme conditions, as well as in order to prevent dysbiosis;
- in order to prevent mastitis for local treatment of the mammary glands of nursing mothers of the "risk" group (in women with an inverted flat nipple, a decrease in its erection, the presence of cracks) in a difficult epidemiological situation in maternity hospitals.
For diseases of the female genital area:
- in case of violation of the purity of the vaginal secretion up to III-IV degree in pregnant women of the "risk" group,
- with bacterial colpitis caused by staphylococcus and Escherichia coli (in monoflora or in associations), as well as with senile colpitis of a hormonal nature.
Contraindications for use.
Hypersensitivity to the components of the drug.
Precautionary measures.
Before using the drug, you should consult your doctor.
Application during pregnancy and during breastfeeding.
The safety of this medicine during pregnancy and lactation has not been evaluated in controlled clinical trials.
Dosage regimen, route of administration.
Bifidumbacterin for intestinal diseases is used orally, and in obstetric and gynecological practice - intravaginally.
Dissolve the contents of the bottle with boiled water at room temperature at the rate of 5 ml (teaspoon) of water per 1 dose of the drug.
Dissolve as follows: pour the required amount of water into a glass (in accordance with the number of doses indicated on the bottle); open the bottle by removing the cap and stopper; transfer a small amount of water from a glass to a bottle; after dissolution (the drug dissolves for no more than 5 minutes with the formation of a homogeneous opaque suspension), transfer the contents of the vial to the same glass and mix. One teaspoon of the drug dissolved in this way is 1 dose. The dissolved preparation can be stored for no more than 12 hours at a temperature of 2 to 25 ° C.
The required number of doses (respectively, teaspoons) should be taken 20-30 minutes before meals. For infants, the drug can be given immediately before feeding.
In case of intestinal diseases: for children of the first half of life, the drug is prescribed 5 doses per reception 2 times a day, for children of the second half of the year and older - 5 doses 3 times a day.
It is advisable for newborns of the "risk" group to start using the drug in the maternity ward from the first day of life until discharge, 2.5 doses per dose 2 times a day.
Children with sepsis, pneumonia and other purulent-infectious diseases are prescribed 5 doses 3 times a day in combination with conventional methods of treating the underlying disease. If this group of children develops disturbances in the function of the gastrointestinal tract and the threat of necrotizing enterocolitis, the dosage of Bifidumbacterin is increased to 20 doses per day.
In acute chronic inflammatory diseases of the small and large intestines, colitis and enterocolitis in adults, it is recommended to take 5 doses 2-3 times a day.
In case of intestinal diseases, the duration of the course of treatment with Bifidumbacterin is determined by the severity of clinical manifestations, the patient's age and is 2-4 weeks, and in some cases - up to 3 months.
Treatment of the area of the nipple and areola of puerperas: soak 2 sterile swabs with a dissolved preparation (5 doses) and apply them to the mammary gland for 20-30 minutes before feeding. The course of treatment is 5 days.
For intravaginal use, insert a sterile swab soaked in the drug into the vagina and leave for 2-3 hours.
In inflammatory diseases of the female genitals and prenatal preparation of pregnant women of the "risk" group, Bifidumbacterin is prescribed 5-10 doses 1 time per day for 5-8 days under the control of restoring the purity of vaginal secretions to I-II degrees and the disappearance of clinical symptoms of inflammation.
If necessary, the course of treatment with Bifidumbacterin can be repeated.
For prophylactic purposes, 5 doses are prescribed 1-2 times a day for 1-2 weeks.
Possible side effects when using the drug.
The side effect of the drug has not been established. If you experience side effects that are not mentioned in the instructions, you should consult your doctor.
Overdose. Overdose cases have not been registered.
Interaction with other medicinal products.
When taken simultaneously with chemotherapy and antibacterial drugs, a decrease in therapeutic efficacy is possible.
Special instructions. Dissolution of the drug in hot water (above 40 ° C) is not allowed. Unsuitable for use is a preparation, the integrity of the packaging of which is broken (cracked vials), a preparation without labeling, in the presence of foreign inclusions.
Influence on the ability to drive vehicles, mechanisms.
Has not been studied.
Release form. Lyophilisate for the preparation of a suspension for oral administration and topical application. 3 or 5 doses per bottle. 10 each; 12 or 14 bottles in a pack (box) made of cardboard with instructions for use.
Storage conditions. At a temperature of 2 to 8 ° C. Keep out of the reach of children.
Transportation conditions. At a temperature of 2 to 8 ° C.
Best before date. 1 year (when kept in a single dose of 1 × 10 ^ 7 to 5 × 10 ^ 7 live bifidobacteria). 2 years (when kept at release in a single dose of more than 5 × 10 ^ 7 live bifidobacteria).
A drug with an expired shelf life is not subject to use.
In addition, there is a dietary supplement Bifidumbacterin, which is similar in composition and purpose to the drug of the same name.
Active substance - bifidobacteria bifidum (lat. bifidobacterium bifidum) - gram-positive anaerobic bacteria belonging to the genus Bifidobacterium (lat. bifidobacterium).
Dosage forms : in vials, ampoules, tablets, powder in laminated foil bags, in the form of candles.
Composition of bifidobacterin
The composition of a specific sample of bifidumbacterin depends not only on the dosage form, but also on the manufacturer. In most cases, bifidumbacterin contains a strain bifidobacterium bifidum No. 1, however, the later developed strains No. 791 or LVA-3 can also be used. Bifidumbacterin powder has the appearance of a crystalline or porous mass of whitish-gray or beige color, and also has a specific taste and smell. When dissolved in water, an opaque suspension is obtained.- Bifidumbacterin sachets made of aluminum foil laminated with polyethylene: one sachet contains at least 500,000,000 freeze-dried live bifidobacteria of an antagonistically active strain bifidobacterium bifidum No. 1, purified from the cultivation medium, and 0.85 g of lactose (manufacturers CJSC "Partner", LLC "Ecopolis", etc.). Lactose, used as an excipient, stimulates the growth of bifidobacteria.
- Bifidumbacterin in the form of vaginal suppositories : one suppository contains at least 10,000,000 live bifidobacteria (1 dose), freeze-dried in a cultivation medium with the addition of sucrose-gelatin-milk medium (manufacturers LLC Firm "Ferment" and LLC "Lanopharm", etc.).
- Bifidumbacterin dry (lat. bifidumbacterinum siccum): one bottle contains a lyophilized powder for preparation of a suspension for oral administration and topical administration of 5 doses (manufacturers LLC Firm "Ferment", LLC "Lanopharm", LLC "Ecopolis", etc.) bifidobacteria bifidobacterium bifidum strains No. 1, 791 or LVA-3 and components of the drying medium: gelatin, sucrose, skim milk.
Indications for the use of bifidumbacterin
- intestinal dysbiosis
- intestinal dysfunction of staphylococcal or unknown etiology
- as part of the complex therapy of acute infectious intestinal diseases (dysentery, salmonellosis, escherichiosis, yersiniosis, rotavirus infection)
- food poisoning
- as part of the complex therapy of allergic diseases
- diseases of the digestive system, lungs, urinary tract and others, accompanied by intestinal dysbiosis
- anemia, weight deficiency, rickets and allergic diathesis in debilitated children
- for the prevention of mastitis by treating the mammary glands in nursing mothers at risk
- early transfer of infants to artificial feeding and feeding with donor milk
- diseases of the gastrointestinal tract of children with aggravated premorbid condition:
- premature or with signs of prematurity
- who received antibiotics in the early neonatal period
- whose mothers suffered from severe toxicosis, extragenital diseases, had a long anhydrous period or other pathology
- diseases of the gastrointestinal tract of mothers' children:
- having lactostasis
- cracked nipples
- resuming breastfeeding after recovering from mastitis
- diseases of the gastrointestinal tract of children with anemia, malnutrition, rickets, diathesis and other manifestations of allergy, patients with whooping cough
- gynecological diseases:
- bacterial vaginosis and colpitis of various etiologies
- rehabilitation of the female genital tract with bacterial and senile colpitis, prenatal preparation of pregnant women at risk with a violation of the purity of vaginal secretions up to III-IV degree
Professional medical publications concerning the use of bifidumbacterin in the treatment of the gastrointestinal tract
- Gracheva N.M., Partin O.S., Avakov A.A., Gavrilov A.F., Solovieva A.I. Probiotics in the complex treatment of patients with gastrointestinal diseases with concomitant intestinal dysbiosis // Attending physician. - 2008. - No. 9.
Method of using bifidobacterin and doses
Oral bifidumbacterin (tablets, powder):- For babies feeding on mother's milk, bifidumbacterin is mixed with milk and given during feeding.
- For bottle-fed children, older children and adults, bifidumbacterin is mixed with the liquid portion of food, preferably fermented milk, and given before meals. It is permissible to mix bifidumbacterin with 30-50 ml of boiled water at room temperature and receive the resulting suspension, without waiting for the complete dissolution of lactose.
- In order to prevent bifidumbacterin taken 1-2 times a day; children under one year old - 2.5 doses, children over one year old and adults - 5-10 doses for 10-15 days 2-3 times a year.
- In the treatment of diseases of the digestive tract, children under one year old take 5 doses of bifidumbacterin 2-3 times a day, children from one to seven years old take 5 doses 3-4 times a day, adults - 10 doses 2-3 times a day. The duration of treatment is from 5 to 15 days. If indicated, treatment can be repeated 2-3 times with a month break between courses.
- For patients with surgical pathology, bifidumbacterin is prescribed for 3-5 days before surgery and for 10-15 days after surgery, 15-30 doses per day.
- In acute intestinal infections, bifidumbacterin is prescribed in therapeutic doses for 5-7 days.
- Prevention of mastitis. 5 doses of bifidumbacterin are dissolved in 10-15 ml of boiled water at room temperature. 20-30 minutes before feeding with a sterile swab soaked in solution, the nipples and areola of the mammary glands are treated for 5 days.
- Gynecology. After antibiotic treatment, to restore the microflora of the vagina. 10 doses of bifidumbacterin are dissolved in 15-20 ml of boiled water at room temperature. A tampon, abundantly moistened in a solution or a suppository, is administered intravaginally for 2-3 hours, twice a day for 5-10 days.
The bacteria contained in bifidumbacterin, despite the beneficial effects, are not equivalent to the human's own microflora and, like all other probiotic strains included in drugs and dietary supplements, are not able to multiply in the intestine for a long time. Even the most effective probiotics work only during the course of treatment and are found in the feces for no longer than one to two weeks after treatment ends.
Interaction: the effect is enhanced by vitamins (especially group B), reduced by antibiotics.
Bifidumbacterin is a probiotic drug designed to eliminate intestinal dysbiosis.
The action of the drug is aimed at normalizing the microflora by replacing live bifidobacteria, which are highly active against pathogenic microorganisms.
On this page you will find all the information about Bifidumbacterin: full instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Bifidumbacterin. Want to leave your opinion? Please write in the comments.
Clinical and pharmacological group
A drug that regulates the balance of intestinal microflora. ...
Conditions of dispensing from pharmacies
Available without a prescription.
Prices
How much does Bifidumbacterin cost? The average price in pharmacies is 90 rubles.
Release form and composition
Several forms of Bifidumbacterin are available: dry, contained in vials, in ampoules, powder agent contained in foil bags, also available in capsules and in the form of suppositories. A liquid concentrate of bifidobacteria is also produced. Bifidumbacterin 1000 is available in tablets.
- The composition of the product includes a dry microbial mass containing live bifidobacteria (that is, those bacteria that are part of the intestinal microflora in a normal state), as well as a bifidogenic factor (one that promotes the growth of bifidobacteria) lactose (a disaccharide found in milk). The preparation (1 dose) contains at least 107 CFU of lyophilized bifidobacteria.
The tablet and the candle contain 1 dose of the drug, all other indicated packaging - 5 doses each. What form of release of the drug is preferable in a particular case is determined by a specialist.
Pharmacological effect
Bifidumbacterin has the ability to normalize the intestinal microflora, to activate the digestion process and the work of the gastrointestinal tract, and also has a positive effect on metabolic processes. In addition, the drug has an immunomodulatory effect, strengthening the body's resistance to various negative factors.
Bifidumbacterin is capable of destroying a wide range of pathogenic bacteria and pathogens. In particular, the drug is active against staphylococci, proteus, enteropathogenic E. coli, as well as some types of yeast-like fungi.
Indications for use
According to the instructions for Bifidumbacterin, it is advisable to prescribe the drug for the following diseases:
- chronic constipation;
- malabsorption syndrome;
- bacterial and;
- allergic diseases, which are characterized by dysbiosis;
- dysbacteriosis with inflammation of the urogenital tract, acute and chronic bronchitis, pneumonia;
- acute intestinal infections (, staphylococcal enterocolitis, shigellosis);
- foodborne diseases and intestinal infections of unknown etiology;
- pathology of the liver, intestines, pancreas - preoperative correction of the intestinal microflora;
- , including after therapy with hormones, antibiotics, during chemotherapy, stress;
- dysbacteriosis that accompany various diseases of the biliary tract, liver, digestive tract, including, and.
Reviews of Bifidumbacterin indicate the effectiveness of this drug in the prevention of mastitis in women who are breastfeeding.
Contraindications
Bifidumbacterin is contraindicated only in case of individual intolerance.
According to reviews, Bifidumbacterin should be used with caution in children with lactose deficiency.
Application during pregnancy and lactation
The safe composition of the drug allows you to use it during pregnancy and lactation. When carrying a child, the remedy normalizes the intestinal and digestive tract microflora; before childbirth, it helps to prevent complications. A solution of powder or lyophilisate is used to treat the nipples of a nursing mother, preventing the development of mastitis.
Instructions for use
The instructions for use indicate that Bifidumbacterin is used orally for intestinal diseases, and intravaginally in obstetric and gynecological practice.
The contents of the bottle are dissolved in boiled water at room temperature at the rate of 1 teaspoon of water per 1 dose of the drug. To do this, the required amount of teaspoons of water is poured into the glass (in accordance with the number of doses indicated on the container label), and then a small amount of water is transferred from the glass into the bottle to dissolve the dry mass. After dissolution, the contents of the bottle are transferred into the same glass and stirred (one teaspoon of the dissolved drug is 1 dose), the required number of such doses is drunk 20-30 minutes before meals. For infants, the drug can be given immediately before feeding.
It is unacceptable to dissolve the drug with hot water and store it in liquid form. In the case of using the bottle in several steps (2-3 times a day) with a dry clean object (spoon, eye spatula, etc.), you can divide the dry mass into approximately 2-3 parts, dissolve the necessary part and use, and the rest of the dry mass store in the refrigerator in a sealed bottle.
- Children under 1 year old (newborns) - 1 sachet 2-3 times a day.
- Children from 1 to 3 years old - 1 sachet 3-4 times a day.
- Children aged 3 to 12 years - 2 sachets 2-3 times a day.
- Children over 12 years old and adults - 2 sachets 3-4 times a day.
The duration of the course of taking Bifidumbacterin powder is determined by the underlying pathology and is established by the doctor individually. The recommended duration of the course of treatment for acute intestinal infection or food poisoning is 5-7 days. For the treatment of dysbiosis, chronic pathology of the digestive system, vaginosis or thrush in women, the duration of taking the drug is 10-20 days. During the prophylactic intake of Bifidumbacterin powder, its dosage is halved.
- For intravaginal administration the preparation is impregnated with a sterile tampon, which is inserted into the vagina and left for 2-3 hours.
- To treat the area of the nipple and its areola in a woman in labor, the drug dissolved in the above way is applied with a sterile swab 20-30 minutes before feeding, 5 doses for 5 days. The swab moistened with the drug is left on the surface of the mammary gland before feeding.
- For inflammatory diseases of the female genitalia and prenatal preparation of pregnant women of the "risk" group, dry bifidumbacterin is prescribed 5-10 doses 1 time per day for 5-8 days under the control of restoring the purity of vaginal secretions to I-II degrees and the disappearance of clinical symptoms of inflammation.
Suppositories Bifidumbacterin for intestinal diseases, it is administered rectally: 3 times a day, 1-2 suppositories in combination with oral administration of the drug. The course of treatment with Bifidumbacterin suppositories for chronic forms of intestinal disorders is 15-30 days, and for acute forms - 7-10 days. In gynecological practice, Bifidumbacterin suppositories are used intravaginally 2 times a day, 1 (1 dose) suppository. The course of treatment is usually 5-10 days.
Side effects
The only side effect may be allergic reactions to taking the drug. In this case, you should stop taking the probiotic and consult a doctor to adjust the further course of treatment. After drug withdrawal, all unwanted symptoms disappear within a short time.
Overdose
Bifidumbacterin powder does not possess cumulative properties and does not accumulate in the body, therefore, an overdose of this drug is impossible. In the case of a single intake of a large amount of powder, the excess of bifidobacteria is excreted from the body in the feces.
special instructions
In the special instructions section of the instructions for use of the drug, it is said that in case of lactase deficiency, Bifidumbacterin should be used with caution. The tool does not affect the concentration of attention and the speed of psychomotor reactions, does not cause drowsiness, therefore, while taking it, it is not forbidden to drive a car, other vehicles and dangerous mechanisms.
Drug interactions
There are no undesirable manifestations when interacting with other drugs. It is allowed to be used for adults and children in combination therapy with antibacterial agents. However, antibiotics reduce the effectiveness of the drug.
Thank you
The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. A specialist consultation is required!
Bifidumbacterin is a probiotic that has the ability to normalize the intestinal microflora and thereby eliminate dysbiosis, indigestion, poisoning, diarrhea, allergic reactions and a number of other conditions caused by an imbalance of intestinal microorganisms. Bifidumbacterin normalizes the digestion process and improves non-specific immunity. Therefore, the probiotic is used to treat intestinal infections and dysbiosis, as well as to improve the nonspecific link of immunity during stress, frequent colds, severe flu, radiation therapy or chemotherapy of tumors, etc.Names, release forms, composition, varieties of Bifidumbacterin and their differences from each other
Today there are several varieties of Bifidumbacterin, which mean different versions of the same drug, registered under different commercial names. The main difference between the varieties of Bifidumbacterin from each other is the names and content of the active component. That is, the varieties of the drug do not have significant differences from each other, which would give them different properties and, accordingly, cause different indications for use. This means that all varieties of Bifidumbacterin are used under the same conditions, but due to a wide choice of dosages and release forms, they provide an opportunity to choose the most convenient version of the drug for each person. For example, it is convenient for some people to take the drug in capsules, for others - in the form of a liquid concentrate, for others - in the form of a solution prepared from a dry powder, etc. Currently, the following varieties of Bifidumbacterin are produced:
- Bifidumbacterin;
- Bifidumbacterin Forte;
- Bifidumbacterin 1000;
- Bifidumbacterin Multi-1;
- Bifidumbacterin Multi-2;
- Bifidumbacterin Multi-3.
Bifidumbacterin 1000 differs from other varieties of the drug by the presence in the composition of not only bifidobacteria, but also lactulose, which is a prebiotic. That is, Bifidumbacterin 1000 is a combined synbiotic containing both a probiotic and a prebiotic. A prebiotic is a substance that is a source of nutrients for members of the normal intestinal microflora. That is, prebiotics are those substances that probiotics "eat". Thus, Bifidumbacterin 1000 contains both bacteria of normal microflora and nutrients for them.
Bifidumbacterin forte differs from all other varieties of the drug in that, in addition to bifidobacteria, it contains a sorbent (activated carbon), which ensures a uniform release of bacteria of normal microflora throughout the entire length of the intestine. In addition, when activated charcoal releases bifidobacteria that attach to the intestinal wall, it binds and removes various toxic substances. That is, Bifidumbacterin Forte simultaneously removes toxic substances from the intestines and populates it with bacteria of normal microflora.
Varieties of Bifidumbacterin are available in the following dosage forms:
- Tablets (Bifidumbacterin 1000, Bifidumbacterin);
- Capsules (Bifidumbacterin, Bifidumbacterin Forte, Bifidumbacterin Multi-2 and 3);
- Dry powder for solution preparation (Bifidumbacterin Multi-1 and 2, Bifidumbacterin Forte);
- Lyophilisate for solution preparation (Bifidumbacterin);
- Oral liquid concentrate (Bifidumbacterin);
- Rectal and vaginal suppositories for adults (Bifidumbacterin);
- Rectal suppositories for children (Bifidumbacterin).
All varieties and dosage forms of Bifidumbacterin contain live bifidobacteria in varying amounts as an active ingredient. Usually, the number of bifidobacteria is measured in CFU (colony forming units), which means the approximate number of microbes that can intensively multiply and colonize the intestines. But the number of bifidobacteria in CFU is indicated not in all varieties of the drug, but only in Bifidumbacterin 1000, Bifidumbacterin Multi-1, 2, 3 and Bifidumbacterin Forte. However, for humans, this does not really matter, since dosages for administration are usually indicated in the number of sachets, vials, capsules or tablets.
In Bifidumbacterin, the number of bifidobacteria is usually denoted in doses. For example, powders can contain 1, 3, 5 or 10 doses, capsules 1 or 5, etc. Accordingly, the admission rules indicate how many doses should be taken for various conditions. For example, if it is indicated that you need to take Bifidumbacterin 15 doses per day, then you should take any dosage form and drink so many powders, capsules, tablets or liquid concentrate during the day to make 15 doses in total. For example, if a packet of powder contains 5 doses, then only three sachets should be drunk, etc.
In the further text of the article, we will use one common name "Bifidumbacterin" to denote all varieties of a medicinal product, since they all have the same indications, contraindications and rules for use. Therefore, it is irrational to describe this for each type of Bifidumbacterin separately. If it becomes necessary to indicate that any property is inherent only in a specific variety of Bifidumbacterin, then this will be done. Otherwise, if there are no such special instructions, then all the information given should be applied to all varieties of Bifidumbacterin.
Bifidumbacterin - photo
These photographs show the appearance of packages of Bifidumbacterin of various manufacturers and varieties.
Therapeutic effects
Bifidumbacterin normalizes the intestinal microflora and has a moderate immunostimulating effect. These effects are provided by bifidobacteria contained in the composition of the drug and are representatives of the normal intestinal microflora. That is, as a result of taking Bifidumbacterin, the intestines are colonized by bifidobacteria, which normally constitute up to 90% of the microflora.So, to dilute dry Bifidumbacterin, you need to take 30 - 50 ml (2 - 3 tablespoons) of a solvent (water, milk, etc.) and pour them into a small container, for example, a glass. Then pour powder from a bag into this container, mix well and drink or pour into a bottle for feeding an infant. If a lyophilisate is used in ampoules, then the solvent can be poured directly into the bottle, mix well with a stick and drink or pour into a bottle for feeding an infant.
When diluting Bifidumbacterin, you do not need to try to achieve complete dissolution of the powder or lyophilisate, since the formation of a turbid suspension is sufficient for the reception. As soon as such a suspension has formed from the solvent and powder or lyophilisate, the drug can be drunk or poured into a formula for feeding an infant.
Bifidumbacterin powder, lyophilisate, tablets and capsules - instructions for use
Powder, lyophilisate, tablets or capsules Bifidumbacterin are taken orally 20-30 minutes before or during meals. Tablets and capsules are swallowed whole, washed down with a small amount of pure water or a fermented milk drink, for example, kefir, yogurt, fermented baked milk, etc. Powder or lyophilisate immediately before taking is dissolved in 30-50 ml of boiled water at room temperature, milk, formula for artificial feeding or fermented milk product. It is optimal for infants to give the dissolved preparation at the very beginning of the next feeding in a separate bottle. When the baby has eaten the contents of the Bifidumbacterin bottle, give him the breast or another bottle with the required amount of formula.
For children under three years old, it is optimal to use a pre-diluted lyophilisate or powder. Children over 3 years old can be given Bifidumbacterin in any form - tablets, capsules, lyophilisate or powder, choosing the option that is most convenient for you.
The dosage and duration of use of Bifidumbacterin powder or lyophilisate depends on the disease or condition for which the drug is being taken. Moreover, adults can take the entire daily dosage of the drug at one time, preferably in the morning, before breakfast. Children are advised to divide the daily dosage into 2 - 3 doses.
So, as a comprehensive preparation for operations it is recommended to take the drug 3 - 5 days before surgery and within two weeks after it, 15 - 30 doses per day.
At chronic diseases of the digestive tract it is recommended to take Bifidumbacterin 25-30 doses 1-3 times a day for 10-14 days.
Before use, the bottle with the liquid concentrate should be shaken well to mix its contents. Then open the lid of the bottle and draw up the required amount of concentrate with a syringe or measuring spoon. If the concentrate is collected with a syringe, then it is simply released directly into the mouth and swallowed. If the concentrate is collected with a spoon, then it is taken into the mouth and the entire preparation is licked off. After each use, the measuring objects (spoon, syringe, cap, etc.) must be washed.
If the drug is given to an infant, then the required amount of concentrate is mixed with 30-50 ml of milk or formula for artificial feeding. Bifidumbacterin is given to the child before feeding so that he can eat the entire volume of milk or a mixture with a concentrate. When the child has eaten the entire volume of milk or formula with Bifidumbacterin, he can be given a breast or a bottle with the required amount of baby food.
Bifidumbacterin forte - instructions for use
Capsules and powder are taken with meals. If the food is irregular, then you can take the drug at any time, regardless of the meal. Capsules are swallowed whole with a small amount of water, and the powder is diluted in water, milk, formula for artificial feeding or fermented milk product immediately before taking. If the capsule cannot be swallowed, then it is recommended to open it, pour out the contents and dilute with water. One sachet of powder or the contents of one capsule is diluted in 30-50 ml of water, milk, etc. Capsules are recommended for use only for children over 3 years of age and adults, and powder - from birth and for any age. The drug is used in standard or increased dosages for any disease. Moreover, therapy begins with standard dosages, and if there is no effect, then they switch to increased dosages.
The standard dosages of Bifidumbacterin for people of different ages are as follows:
- Children under one year old - 1 sachet 2 - 3 times a day;
- Children 1 - 12 years old - 1 sachet or 1 capsule 3 - 4 times a day;
- Children over 12 years old and adults - 2 sachets or 2 capsules 2 - 3 times a day.
In increased dosages, Bifidumbacterin Forte is used in adults and children over a year old. Increased dosages depending on age are as follows:
- Children 1 - 12 years old - 5 packages or 5 capsules, 3 times a day;
- Adults - 10 packages or 10 capsules 3 times a day.
For chronic diseases of the digestive tract, Bifidumbacterin Forte is taken in increased dosages for 10-14 days.
For prophylaxis, the drug should be given 1 sachet per day to children under one year old, and to all other people - 1 - 2 sachets (1 - 2 capsules) 1 - 2 times a day for 2 weeks. Preventive courses can be carried out 2-3 times a year.
Bifidumbacterin 1000 - dosages
The tablets should be taken with meals, with a little water or a fermented milk drink. The duration of therapy and doses depend on age:- Children 3 - 14 years old - 1 - 2 tablets 3 times a day for a month;
- Adults and adolescents over 14 years old - 2 tablets 2 to 3 times a day for 1 to 3 months.
Bifidumbacterin suppositories - instructions for use
Suppositories (candles) are available in two varieties - for children and adults. Babies are intended for babies up to 3 years old and can only be injected into the rectum. Adult suppositories are intended for children over 3 years of age and adults and can be inserted into the rectum or vagina. Vaginal use of suppositories takes place in gynecological practice. And for the treatment of dysbiosis, allergies and bowel diseases, suppositories are used rectally. So, for the treatment of intestinal diseases and dysbiosis, children and adults should be administered 1 - 2 suppositories 3 times a day. In this case, for children under 3 years old, you should take children's candles, and for everyone else - adults. In acute intestinal infections, the duration of therapy is 7-10 days, and in chronic diseases - 15-30 days.
Bifidumbacterin in gynecology
Bifidumbacterin in gynecology is used in the form of suppositories for adults, which are inserted into the vagina. Suppositories are used in the complex therapy of dysbiosis (bacterial vaginosis), colpitis and inflammatory diseases of the genital organs. In this case, 1 candle should be injected 2 times a day for 5 to 10 days.At III-IV degree of purity of the vagina, 1 suppository should be injected 1 - 2 times a day until, according to the results of the smear, the I-II degree of purity of the secretion is reached and the clinical symptoms disappear.
For the prevention of infectious complications of elective surgery or childbirth, it is recommended to administer 1 suppository 1 to 2 times a day, within 5 to 10 days before the expected date of surgery or delivery.
To eliminate dysbiosis caused by taking antibiotics, it should be administered in 1 suppository 2 times a day for 10 days. If necessary, the course of therapy is repeated after 3 to 4 months.
Bifidumbacterin for children and newborns
The drug can be used in children from two weeks of age in the form of powders and lyophilisates for the preparation of a solution for oral administration. From one month, you can use baby rectal suppositories Bifidumbacterin. When the child reaches 3 years of age, you can give him the drug in the form of capsules.For children, it is recommended to use special varieties of the drug - Bifidumbacterin Multi-1, 2 and 3, developed for different ages, taking into account the characteristics of the intestinal microflora. So, Bifidumbacterin Multi-1 is intended for children from birth to 3 years old, Multi-2 - from 3 to 12 years old, and Multi-3 - from 12 to 18 years old. These types of the drug are very convenient, since the dosage of the powder and capsules exactly corresponds to the norms for children of different ages.
Side effects and contraindications for use
All varieties of the drug are contraindicated for use only with individual intolerance to the components. Capsules and tablets are contraindicated for use in children under 3 years of age.As a side effect, Bifidumbacterin can only provoke allergic reactions, in the event of which the drug should be discontinued.
Analogs
Other probiotics containing bifidobacteria are considered analogs of Bifidumbacterin.The synonyms for Bifidumbacterin include the following probiotics:
- Bacterial balance;
- Biovestin-Lacto;
- Bion-3;
- Bifidine;
- Bifidobacus;
- Bifidok;
- Bifidum 791-BAG;
- Bificol;
- Bifilin;
- Bifilong;
- Bifinorm;
- Bifiform and Bifiform Baby;
- Beefainol;
- Bonolact Pro + Biotic;
- Bonolact Re + General;
- Polybacterin;
- Primadophilus Bifidus, Primadophilus Children's and Primadophilus Junior;
- Probifor;
- Protozymes;
- Symbiolact;
- Florin forte;
- Ecoflor;
- Euflorin V.
Means "Bifidumbacterin" for children - instructions for use allow it to be taken from birth - is one of the best drugs that restore the disturbed microflora of the gastrointestinal tract.
The composition of the probiotic "Bifidumbacterin"
The composition of the tool may include strains of bifidobacterium bifidum No. 1 or No. 791. Sometimes it is LVA-3.
The powder of the preparation is a crystallized (sometimes porous) substance of beige or white-gray color. The product has an unusual (bready) taste and smell. After adding the liquid, it forms an opaque suspension.
- "Bifidumbacterin" supplied in a sachet contains approximately 500 million specially prepared bacteria of the bifidobacterium bifidum strain No. 1 and lactose (0.85 g).
- Dry "Bifidumbacterin" is offered in transparent glass bottles in the form of a lyophilized powder. It is used for the preparation of a suspended preparation. Contains five therapeutic doses. The auxiliary substances here are gelatin, milk (skim) and sucrose.
Forms of release of the drug "Bifidumbacterin"
Pharmacies offer the following forms of the remedy:
- Dry powder. The product is packed in glass bottles, metal-polymer sachets. Contains five therapeutic doses.
- "Bifidumbacterin Forte". Capsulated form for oral administration.
- Candles.
- Dried (lyophilized) mass. It is used to prepare a liquid form of a drug for oral administration.
- Liquid "Bifidumbacterin".
Indications for taking "Bifidumbacterin" in childhood
"Bifidumbacterin" can be prescribed for the following conditions:
- dysbiosis of the gastrointestinal tract;
- various intestinal pathologies, in particular salmonellosis, rotavirus infection, etc.;
- toxic and intestinal infections of unknown origin;
- violation in the suction function of the gastrointestinal tract;
- with chronic constipation;
- allergic reactions that can provoke the development of dysbiosis.
"Bifidumbacterin" is recommended for admission to newborns receiving artificial formula or breastfed donor breast milk. The drug promotes the formation of the necessary intestinal microflora, significantly reducing the strength of intestinal colic. Reviews of women who used the drug in this particular direction confirm its effectiveness.
Contraindications to taking the drug "Bifidumbacterin"
The drug is contraindicated in case of existing individual intolerance to the component composition.
The use of the drug in childhood
Drinking "Bifidumbacterin" is necessary either before meals - about thirty minutes - or at the same time.
- The capsules must be swallowed whole with clean water or any fermented milk product.
- Before use, the dose of powder / lyophilisate is diluted with cold boiled water (volume 30.0 ... 50.0 ml). You can also use milk, formula milk, and fermented milk drinks.
Children (until the age of three full years) are recommended to give the medicine in the form of a diluted powder or lyophilisate. In the future, any form of the tool can be used.
How to give the drug? In case of infection of the gastrointestinal tract and food poisoning, the probiotic is prescribed according to the following scheme:
- five to ten therapeutic doses twice a day;
- the duration of therapy is 7 ... 10 days.
With a severe form of pathology, treatment can be extended up to two to four weeks.
Taking a probiotic for dysbiosis:
- ten doses 2 ... 3 times within 24 hours;
- duration of admission - 5 ... 15 days (maximum duration of therapy - two months).
Average doses of the drug "Bifidumbacterin" in the treatment of other diseases:
- from birth to one year - five doses 2 ... 3 times every 24 hours;
- one year - seven years - five doses 3 ... 4 times within 24 hours;
- over seven years - ten doses 2 ... 3 times in 24 hours.
The drug can be used prophylactically. The dosage will depend on the age of the child:
- babies up to a year - 2.5 doses no more than twice a day;
- over a year - five to ten doses up to two times a day.
The duration of the prophylactic admission should not exceed 15 days. The courses can be held 2 ... 3 times a year.
Dr. Komarovsky believes that giving the child the probiotic "Bifidumbacterin" is for preventive purposes. in the absence of any indication, not worth it. After all, this is not a food supplement, but a drug.
How to take liquid "Bifidumbacterin"
The child is given liquid "Bifidumbacterin" half an hour before meals, two to three times during the day. Before use, the bottle with the drug must be shaken well to achieve uniformity.
Liquid dosage:
- babies up to a year - 0.5 ml twice a day;
- one year ... twelve years - 0.5 ... 1 ml up to three times a day;
- over twelve years old - 1 ... 2 ml up to three times a day.
The duration of the course is two ... three weeks. In some cases (at the discretion of the attending physician), the duration of therapy can be increased to two months.
Quite often, the drug "Bifidumbacterin" is prescribed at the same time as taking antibiotics. In this case, the remedy is taken three hours after the antibiotic.
Instructions for taking "Bifidumbacterin Forte"
"Bifidumbacterin Forte" differs from other forms of the drug. Here the bacteria are cultured colonies. After entering the child's body, they begin active reproduction, suppressing all pathogenic microflora
This form of the product is taken with meals.
- If the child is old enough, he can take capsules.
- For babies, a powder of the preparation is used, which must be diluted in water or milk (30 ... 50 ml).
Bifidumbacterin Forte therapy begins with a standard dosage. In the absence of the expected therapeutic effect, increased doses are prescribed to the baby.
Standard dosage:
- babies up to a year - package 2 ... 3 times a day;
- one year… twelve years - sachet / capsule up to four times a day;
- over twelve years old - two sachets / capsules up to three times a day.
Increased doses:
- one year ... twelve years - five sachets / capsules three times a day.
An increased dosage of the drug can only be used in babies who are already one year old.
Analogues of the drug "Bifidumbacterin"
The tool belongs to the category of probiotics containing bifidobacteria in the composition. The list is long enough. The most famous are:
- Biovestin;
- Linex;
- "Normoflorin B";
- "Probifor".
Probiotic storage conditions and shelf life
You need to store the drug at room temperature for no longer than a year from the date of packaging. The date is printed on the box.
Side effects when using the drug
The only side effect can be called the development of allergies, as a reaction to auxiliary components. If symptoms of an allergic reaction appear, the drug must be canceled.
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