If you suffer from anxiety, you will most likely be interested in learning about a 100% natural remedy for calming the nerves. This remedy is a natural sedative created by nature itself. This mineral is involved in over 300 biochemical reactions in the body that regulate processes ranging from blood pressure and energy production to muscle relaxation and blood sugar levels. We all know magnesium improves sleep, but how effective is it in fighting anxiety?
The relationship between magnesium, also known as the “natural relaxing mineral,” and anxiety is complex and depends on many factors. It is best to start explaining this connection with; many of us are likely not getting enough magnesium from our diet, which creates a magnesium deficiency and increases the risk of anxiety.
Magnesium deficiency and anxiety.
“ Magnesium deficiency is fairly common in the United States - as is anxiety ”Says Eileen Ruhoy, MD and PhD, an integrated neurologist and a member of the MindbodygreenCollective community.
But how common is this problem, to be precise?
It is estimated that 50 to 90% of Americans suffer from magnesium deficiency. The reasons for this are the use of medication, soil depletion, and the standard American diet of predominantly refined and processed foods that contain little or no magnesium.
With over 3,700 molecules in the human body associated with magnesium, magnesium deficiency can affect health in many different ways. When it comes to anxiety, magnesium's role in the functioning of the parasympathetic nervous system (PNS) is of particular interest. The PNS is known as the “rest and digestion” system and is responsible for bringing the body back to rest.
Magnesium plays a key role in maintaining the health and functioning of the parasympathetic nervous system and the nervous system in general, and research shows that magnesium deficiency can stimulate the part of the nervous system that is responsible for the fight-or-flight response.
Magnesium and Anxiety
For those of us who suffer from generalized, social anxiety, panic attacks, PTSD, or other anxiety disorders, the idea that magnesium supplementation will provide relief and substitute pharmaceuticals that have side effects and cause addiction.
But can magnesium really help manage anxiety?
Research on this topic is still ongoing, but according to the best doctors in integrative and functional medicine, everything indicates that the answer to this question is yes.
“
Several studies have shown that taking magnesium is beneficial for anxiety, improves well-being, and brings feelings of peace, contentment, and resilience.
, ”Says Rukhoi.
We are still not sure what exactly explains this connection, it is likely that magnesium is an important cofactor in the synthesis of two neurotransmitters that affect our mood and ability to relax. Magnesium also affects the activity of GABA, an important inhibitory neurotransmitter closely associated with anxiety (benzodiazepine drugs such as Xanax, the most popular anti-anxiety drugs, act on the GABA receptors).
Several studies have shown a link between magnesium deficiency and worsening in mood disorders.
Research on magnesium and anxiety.
Marvin Singh, MD, holistic practitioner and member of the MindbodygreenCollective, says: “Magnesium is one of my favorite simple and natural remedies. An article published in 2016 noted the effectiveness of magnesium in treating anxiety, with positive results in cases of mild anxiety and anxiety associated with PMS. .”
However, not all studies have been as convincing: ”Later in 2017, a systematic review found that while there is evidence for magnesium's benefits in treating anxiety, stronger evidence is needed.
, ”He explained.
How to take magnesium to relieve anxiety.
The bad news is that the results of studies on magnesium's effectiveness in fighting anxiety are not yet conclusive, the good news is that it is relatively safe to experiment with magnesium and many people use it with positive results.
Singh adds: “While we haven't yet figured out exactly how magnesium fights anxiety, taking magnesium is a great way to get yourself back into a relaxed state. You can take magnesium supplements in powder, capsule, or liquid form. It is worth noting that magnesium is part of many laxatives and loose stools may occur when taken.
”
This means that certain forms of magnesium, such as magnesium sulfate and oxalate, can cause diarrhea if taken too much.
To avoid this side effect, you can use, for example, pumpkin seeds, dark chocolate, and legumes such as black beans, etc. instead of additives.
How should magnesium be taken to combat anxiety?
If you are already thinking about buying magnesium supplements, you need to be prepared for the fact that you will be amazed at the variety of forms of this mineral. You should know that some forms are more effective.
So how should you take magnesium to relieve anxiety?
There are several magnesium salts, as well as magnesium threonate, citrate, gluconate, and citramate. Magnesium glycinate is an excellent choice, which does not cause digestive upset, unlike almost all other forms.
What else should be taken care of for security reasons?
According to Singh: “If you are suffering from kidney disease, heart disease, arrhythmias or some other medical conditions, you should consult your doctor before taking magnesium supplements. .”
Basically, you should inform your doctor that you are about to start taking any new supplements, herbs, or fundamentally change your lifestyle or diet.
Another tip from an expert?
If you want to increase your magnesium intake, don't limit yourself to capsule or powder supplements. You can try magnesium oils or creams, and even Epsom bath salts, which are made from magnesium sulfate crystals.
These techniques are especially good because they additionally calm you and help you make time for yourself, which increases your effectiveness in dealing with anxiety.
Translation from English
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Fifty years before the first use of magnesium in medicine (1906), Fyodor Mikhailovich Dostoevsky wrote in his diary: “… I turned around all night, slept for half an hour. The gloomy dawn did not bring joy. Longing and anxiety holds the heart with its claws. I am writing, but a lump rolls up to my throat, I can't breathe, tears stand in my eyes, and my hand is cramping from constant writing. " A modern neurologist, having read such words, will immediately say: there are all the signs of magnesium deficiency in the body, a diet and magnesium-containing drugs are shown.
What is magnesium for?
Magnesium is an element that is involved in most key physiological processes. It is extremely important for the normal functioning of cells, muscles and especially nervous tissue. The human body is not able to synthesize magnesium on its own and therefore receives it only through food. Magnesium is necessary for all systems of the body, without exception, it "starts the work" of many enzymes involved in energy, protein, carbohydrate and fat metabolism. Only 300 biochemical processes directly depend on it, and indirectly - several orders of magnitude more. For example, magnesium plays an important role in the prevention of diabetes.
The great importance of magnesium is that it serves as a natural anti-stress factor, inhibits the development of excitation processes in the central nervous system and reduces the body's sensitivity to external influences, relieves the symptoms of anxiety and irritability. The fact is that physiologically all extreme influences lead to an increase in the release of adrenal hormones, an increase in adrenaline in the blood. This removes magnesium from the cells via the kidneys. Therefore, almost all stress can be treated with magnesium.
In addition, independent research by Russian scientists - professors of the International Institute of Microelements "UNESCO" A.A. Spassov, Ya. I. Marshak - showed that the restoration of normal levels of magnesium reduces the craving for alcohol, drugs and smoking, and especially effective in the treatment of addiction therapy with "heavy artillery" - special magnesium-containing drugs.
In addition, magnesium is known to prevent the formation of calcium oxalate stones, which is the most common cause of urolithiasis. Studies have shown that consuming 500 mg of magnesium per day can reduce the incidence of stone formation by 90 and a half percent.
Mineral-norm
For all its importance, magnesium is also the most vulnerable trace element in our body. Its balance is very easy to upset. The daily requirement of an adult for magnesium is 300-350 mg. Since this microelement in the body is not produced on its own, then this entire dose must be supplied with food. But, unfortunately, over the past 100 years, we have begun to receive much less magnesium. This is most often due to improper nutrition. In the modern diet, there are very few products with a maximum magnesium content - unrefined cereals, as well as fresh fruits and vegetables. The situation is aggravated by the fast food system, which is based on the use of refined food, excess sugar and salt, as well as products that remove magnesium from the body - for example, phosphoric acid contained in Coca-Cola and other lemonades, various preservatives and other "E ".
What are the causes of magnesium deficiency?
Magnesium deficiency may be due to the following factors:
Inadequate dietary intake: poor diet, low calorie diet, alcohol consumption, drinking soft water, chronic or prolonged diarrhea. Increased need: for example, during growth, pregnancy, breastfeeding; with intense physical exertion, in situations of stress and increased mental stress; during the rehabilitation period after serious illnesses and injuries. Taking some medications can also be the reason for its deficiency (diuretics, cardiac glycosides, antibiotics (especially aminoglycosides), corticosteroids, oral contraceptives, hormone replacement therapy, anti-inflammatory drugs, etc. Low solar insolation: winter period of the year, work in dark rooms.
What Symptoms Indicate Magnesium Deficiency?
The first symptom is usually increased fatigue, a tendency to depression. Other manifestations include twitching of the eyelids, feeling tense, memory impairment, falling asleep or insomnia, night cramps, sometimes numbness, dizziness, irritability, palpitations, heart problems, feeling short of breath, and a lump in the throat. Magnesium deficiency can lead to a vicious cycle: a deficiency of this mineral contributes to the development of stress, which in turn increases its deficiency. A more pronounced lack of magnesium can lead to the development of cardiovascular (arrhythmia) and gastrointestinal disorders.
Comments (1)(visible only to specialists verified by the MEDI RU edition)
Magnesium- one of the most important elements for the body. Without it, cells are unable to function, because it is present in absolutely all tissues of the body. Muscle contraction, translation of nerve impulses, metabolic reactions - magnesium is involved in all these processes. That is why, to normalize the patient's condition, the doctor prescribes Magnelis B6 with VSD, which includes Magnesium.
Magnesium appears in the body due to the absorption of food. If the diet is violated for any reason, then the person is forced to take diuretics. And also with stress, pregnancy and increased various loads on the body, there may be a lack of magnesium in the body.
Syndromes and symptoms with VSD have no connection with physical disorders. The causes of these manifestations in VSD have not yet been fully understood. Therefore, this condition can in no way be distinguished as a separate disease. For this reason, in the treatment of VSD, symptomatic treatment of Magnelis B6 is prescribed.
The biggest mistake in the treatment of VSD is the treatment with magnesium preparations of those signs that must be treated with the use of antidepressants. A magnesium deficiency in the body must be confirmed by laboratory tests, because an excess of magnesium can also lead to very negative consequences.
If mental disorders are not properly treated, they will progress. For example, panic attacks can easily transform into agoraphobia, which, in turn, negatively affects the patient's work and quality of life. Prolonged depression can be the consequences of this condition.
Magnelis B6 with VSD is often prescribed as a drug for stress. This approach is not entirely correct. It is possible to take Magnelis B6 with VSD with a laboratory established lack of magnesium.
Magnelis B6 is also prescribed in the presence of the following symptoms:
- anxiety and fears;
- sleep disorders of varying severity;
- rapid fatigue and the associated disability;
- excessive irritability;
- bad mood during the main period of time;
- spasms in the muscles and in the gastrointestinal tract.
For adults, a three-time daily intake of Magnelis B6 is attributed. During it, you need to drink 6-8 tablets of Magnelis B6. It is best to take Magnelis B6 with VSD directly in the process of taking a meal, washing down the tablets with water.
How much to drink Magnelis B6 with VSD for children depends on body weight. If the weight is over 20 kg, then the number of tablets per day can reach 4-6 pieces.
Side effects in the process of taking Magnelis B6 with VSD can manifest itself in the form of nausea, vomiting, flatulence and abdominal pain. Allergic reactions also have the ability to manifest themselves when using Magnelis B6.
Magnelis B6 poisoning with VSD can occur with renal failure. Its symptoms are vomiting and nausea, low blood pressure and impaired reflexes after taking Magnelis B6. The most serious consequences after taking Magnelis B6 are cardiac arrest and coma at the time of VSD. In severe poisoning of Magnelis B6 with VSD, intensive care measures should be prescribed.
During the period of bearing a child, Magnelis B6 with VSD is taken in strict accordance with the doctor's recommendations. During breastfeeding, it is better to refrain from taking Magnelis B6 with VSD.
One of the most important functions of Magnelis B6 in VSD is that it serves as an anti-stress factor. This is due to the fact that Magnelis B6 slows down the processes of excitation of the central nervous system and because of this, the patient ceases to overreact to external stimuli.
The nervous system is extremely sensitive to magnesium deficiency. A decrease in it in the body is manifested by nervousness, causeless fears and anxiety, insomnia and fatigue, and frequent headaches.
Magnesium, together with vitamin B6, normalizes the nervous system during stress, depression and stress. Any stress significantly increases the body's daily need for magnesium, which is why patients need Magnelis B6 for VSD.
This combined magnesium preparation belongs to the second generation of magnesium-containing substances and is absorbed in the body as well as Magnelis B6. Magne-B6 is effective in a complex of measures (along with antidepressants) for neuroses. Together with anticonvulsants, this drug is good for treating convulsive conditions. For sleep disorders, it is used together with sleeping pills and as an analogue of Magnelis B6 for VSD.
Alcohol abuse is one of the main causes of magnesium deficiency in the body. Although taking Magnelis B6 with VSD does not prohibit alcohol intake, doctors still do not recommend taking them at the same time. It would be best to refuse to take alcoholic beverages during the course of Magnelis B6 treatment with VSD. When interacting with alcohol, Magnelis-B reduces its effectiveness up to the complete disappearance of the therapeutic benefit in VSD. Allergic reactions to the drug can be aggravated by the incompatibility of Magnelis B6 with alcohol.
Such a state with VSD, like panic attacks, is also to some extent associated with a magnesium deficiency. Indeed, if we talk about the fact that it is magnesium that protects the body from stress, then a panic attack arises precisely on the basis of anxiety and fear. That is, under stress. Therefore, magnesium for panic attacks is necessary in the form of the use of Magnelis B6.
Patient reviews on the use of Magnelis B6 at the time of VSD:
Anna, 42 years old.
“I suffered for 6 years until it turned out that it was the lack of magnesium that provoked panic attacks. A couple of Magnelis B6 tablets with VSD a day and I am already quite comfortable being outside my apartment. Thank you Magnelis B6. "
Anton, 55 years old.
“I had terrible cramps from a lack of magnesium. Magnelis-B6 was prescribed by a doctor after any tests. Magnelis B6 helped solve the problem. "
Dmitry, 52 years old.
“I have no other diagnosis, except for VSD. At the same time, panic attacks are simply terrible - chills, nausea, tremors in the body. After the start of the use of Magnelis B6 with VSD, it became easier. "
Nina, 31 years old.
“I have long been diagnosed with VSD, magnesium supplements were periodically prescribed along with all sorts of other medications. It is difficult to say which ones had a stronger effect, but the doctor told me that Magnelis B6 should be taken in conjunction with other drugs to alleviate the condition with VSD. "
Jeanne, 49 years old.
“It was a difficult period at work, plus constant overwork throughout the year. Insomnia started constantly from the nerves. Then I began to take Magnelis B6 and eat right. It became much better and, although I had to work in the same intense mode, I no longer felt so tired thanks to Magnelis B6. "
Magnesium deficiency in the body can lead to the appearance of various diseases. Lack of many minerals (iodine, zinc, chromium, etc.) leads to various diseases.
But in the era of toxicity in the world around us, magnesium is:
- One of the most common minerals for its lack in the human body.
- One of the most dangerous for human health when it is lacking in the body.
Everyone needs to know about this.
Moreover, there is good news.
Magnesium deficiency in the human body is easy to fix!
1. Most people are deficient in magnesium.
1) USDA states that about 60% of adults do not consume the average amount of this mineral per day.
2) Scientists believe that 80% of people do not get enough of this mineral from food and are sick because of this deficiency, which leads to the accumulation of toxins in the cells and blood.
2) Many experts call this the daily and necessary minimum. They believe that the dose should be individual for different people.
And this is due to the different amount of stress (measured by the level of cortisol) and the amount of toxins in the body, and, probably, in some cases, it can be 1000 mg.
3) Toxic substances in the body have a destructive effect on organs, tissues and cells.
Magnesium participates in many biochemical reactions in the body to remove toxins from the body.
The presence of toxins in the body leads to a decrease in magnesium from the body.
1) To the emergence of a variety of allergic reactions.
2) Frequent colds and flu. Now the World Health Organization believes that the incidence of influenza is associated in most cases not with the virus itself, but with the body's response to the chemical stress caused by the virus.
3) Diabetes mellitus (diabetes mellitus is associated with toxic stress, chemical stress and a deficiency of certain substances, especially magnesium).
4) To heart disease, stroke and many other diseases. You may find the article "Dangerous Signs of Magnesium Deficiency" helpful.
5) Scientists have found that psychological stress leads to the movement of magnesium from the intracellular to the extracellular space, thus increasing the excretion of magnesium in the urine and a decrease in its amount in the body.
6) The connection between magnesium and depression.
Depression is easily and best treated with magnesium.
Magnesium levels in the body are key to mental and emotional health.
7) Alcohol, stress, and magnesium.
During times of stress, some people reduce stress by increasing their alcohol consumption.
And alcohol lowers the level of magnesium in the body.
Alcohol intake increases the excretion of magnesium in the urine by 260% (this is not a mistake, two hundred and sixty percent) above the baseline values.
And this happens within a few minutes after drinking alcohol.
So decide now whether alcohol is good for your health!
On the other hand, by increasing the consumption of magnesium, the need for alcohol, that is, the desire to drink, decreases.
It is useful to know this in Russia!
"eight)" Magnesium deficiency in the body also appears in children.
In 2002, the American Journal of Epidemiology published the results of a study of the diets of 2566 children aged 11-19 months. It was shown that less than 14% of boys and 12% of girls had an adequate intake of magnesium.
9) Magnesium deficiency can be a big problem.
When describing magnesium deficiency, signs of its deficiency, different levels are distinguished.
A marginal (borderline) magnesium deficiency can easily translate into more significant health problems when stressful events trigger additional magnesium losses.
In extreme situations, a decrease in the amount of magnesium in the body can lead to cardiac arrest.
Therefore, during stressful situations, do not drink alcohol if you want to live. Drink herbs - adaptogens and drink them with magnesium.
Read about this in the article "Seven herbs reduce the level of the stress hormone cortisol"
10) Even a moderate magnesium deficiency can lead to increased sensitivity to noise, nervousness, irritability, depression, mental disorders, seizures, and insomnia.
Why do Americans always smile? Indeed, in 60 - 80% of Americans, scientists noted a magnesium deficiency. Or do they have this deficit less than the residents of Russia?
Go to the subway, bus, tram. Almost all people are gloomy, tired and nervous.
Every person now has problems and taking more magnesium will not solve them, but it will be easier to endure all the hardships of life.
11) How much magnesium is in water?
The World Health Organization (WHO) has recommended drinking water with 25-50 mg magnesium per liter to prevent death from heart attack and stroke.
American bottled water contains 5 mg per liter, which is significantly less than the recommended dose.
Many brands of bottled water are sold in Russia.
In "Royal water", which is used for coffee machines, the magnesium content is not more than 20 mg per liter.
In the water "Shishkin Les" - 0.055 mg per liter.
In Arkhyz water - 5 - 20 mg per liter.
In the water "Frutonyanya" - 5 - 35 mg per liter.
In Borjomi water - 50 mg per liter.
In water "Essentuki 4" - less than 100 mg per liter.
In water "Essentuki 17" - less than 150 mg per liter.
In water "Essentuki 20" - less than 100 mg per liter.
As you can see, medicinal - mineral waters have doses of magnesium recommended by WHO, and ordinary drinking waters have low concentrations of magnesium.
12) Magnesium deficiency causes serotonin deficiency.
Serotonin is a neurotransmitter, it is also called "the hormone of good mood" and "the hormone of joy." It has many functions in the body.
But its lack is dangerous to health, aberrant behavior may occur (this is a cardiological term, arrhythmias, etc.), depression and other undesirable phenomena for life.
Another article wrote that dietary factors can play a significant role in the origin of ADHD and that magnesium deficiency can lead to destructive behavior.
13) A significant number of researchers have shown that 60 - 90% of illnesses are directly caused or aggravated by stress.
Indeed, numerous studies have shown that stress is linked to underlying medical conditions such as heart disease, high blood pressure, and diabetes.
Currently, few experts doubt that stress can kill, which means that a lack of magnesium can send a person to the grave.
And it is so easy to add to the body!
This concludes this article, but I will write more about magnesium.
I wish you have adequate levels of magnesium in your body and good health.
In order for health to be normal, the body needs to regularly receive a number of vitamins and minerals. Most of them come with food. Theoretically, if a person is absolutely healthy and eats right, then he does not need a special diet that involves the inclusion in the diet of a large number of foods containing one or another useful element, much less taking special medications and biological additives, which include such elements. However, the rhythm of modern life and the quality of food do not allow us to saturate the body with everything it needs, which can lead to malaise, weakness, or even some kind of disease. Especially important are nutrients that support the work of the cardiovascular system, including magnesium and vitamin B6. Their deficit must necessarily be replenished, otherwise serious health problems may arise. This can be done using special preparations.
It is a drug that is a synthesis of magnesium and vitamin B6. These two elements are ideally combined, and it is thanks to their complex action that the maximum therapeutic effect can be obtained. In addition, vitamin B6 enhances the absorption of the mineral, which is the main ingredient.
The drug supports the health of the cardiovascular, nervous, muscular and skeletal systems of the body.
Scientists, after conducting a study, came to the conclusion that the nutrition of a modern person cannot provide him with the required amount of magnesium. On average, the deficit is 70%.
A lack of the mineral can provoke unpleasant symptoms and the development of serious diseases. Deficiency of vitamin B6 also does not affect well-being in the best way, since this vitamin is of considerable importance for the normal functioning of the nervous system. Magnesium B6 helps to replenish these nutrients.
Improper diet is the main cause of magnesium deficiency in the body
Table: daily consumption rate
* If one tablet contains 470 mg of magnesium lactate dihydrate, which corresponds to 48 mg of magnesium. The drug has instructions with an exact indication of the dosage.
The drug is prescribed to normalize body functions and eliminate the symptoms of magnesium deficiency. In this case, the decision on the need to take the drug should be made by the doctor. Sometimes it is prescribed even in cases where normal levels of the mineral have been detected in the blood and its serum.
- To restore the nervous system in the event of any, even, at first glance, minor disorders, ranging from mild irritability to severe forms of vegetative vascular dystonia and cardioneurosis.
- To normalize blood pressure in hypertension.
- To eliminate pain in the heart and heart rhythm disturbances. If the cause of heart ailments lies not in a functional disorder, but in a serious heart disease, then the supplement is prescribed in combination with other drugs.
- For the treatment of muscle cramps.
The need for taking Magnesium B6 is assessed, among other things, by the woman's well-being during menstruation and menopause. The hormonal background is directly related to the nervous system, which is why they have a significant effect on each other. For this reason, the premenstrual symptom occurs. Another common phenomenon: vegetative-vascular dystonia during menopause or at certain periods of the cycle. The appearance of this kind of ailments may indicate the need for the appointment of "recharge".
Magnesium deficiency immediately affects the state of health, manifesting itself with headaches and other unpleasant symptoms.
It is imperative to ensure that there are no signs of deficiency during pregnancy. During this period, a woman's heart already has a heavy load. In addition, a lack of magnesium provokes cramps and cramps in the muscles (pregnant women often complain about this), which is why it can cause miscarriage, as it leads to an increase in the tone of the uterus and an increase in contractions of its smooth muscles.
Magnesium B6 is as good for men's health as it is for women. It is known that deficiency has an extremely negative effect on the production of testosterone, which has a direct effect on the entire body of a man, from the genital area to the psychoemotional one. Therefore, men cannot ignore the lack of these nutrients.
During the period of growth, especially puberty, the body spends a lot of useful elements on its development, as a result of which their deficiency may arise. This macronutrient has a direct effect on the formation of the cardiovascular and nervous system, therefore, its deficiency can be extremely dangerous and provokes the development of various diseases. For this reason, the slightest suspicion of a deficiency is the basis for determining its level in the blood and the appointment of Magnesium B6.
A list of symptoms that occur with magnesium deficiency in the body:
- headache;
- tachycardia;
- arrhythmia;
- muscle cramps;
- irritability;
- insomnia;
- premenstrual syndrome;
- lazy bowel syndrome;
- anxiety and neurasthenic disorders;
- photosensitivity and sensitivity to noise;
- hypertension;
- an increased level of platelets in the blood.
The listed symptoms can occur not only in the case of a deficiency, but also if the body lacks some other useful substances. In addition, they are common to a variety of diseases. Therefore, their occurrence cannot unambiguously indicate the need for supplementation. In order to confirm the suspicions that have arisen, it is necessary to pass tests for the level of magnesium in the blood.
Magnesium supports the functioning of various organs and systems of the body
Contraindications
Rarely, but still there are people who are forbidden to specifically consume magnesium B6. Their body is able to assimilate the substances included in it only in the composition of food.
- Allergic reactions and individual intolerance.
- Phenylketonuria.
- Renal failure and other kidney diseases.
- Age up to 6 years (when it comes to the solution - up to 1 year).
- Breastfeeding period.
- Taking laxatives. In this case, magnesium can cause serious digestive distress.
- Diabetes. This is because sucrose or fructose are often present in magnesium B6 tablets as additional ingredients.
- The use of tetracycline antibiotics or calcium preparations. Together with magnesium, antibiotics cannot be absorbed normally. In the case of calcium, the opposite is true: magnesium is not absorbed. If there is an urgent need to take magnesium together with the listed drugs, you need to ensure that an interval of at least 3 hours is maintained between the intake.
Their occurrence is extremely rare, but, nevertheless, such a possibility should be taken into account.
- Allergic reactions.
- Disruption of the digestive organs (stool disorders, nausea and vomiting, etc.).
- Peripheral neuropathy (unpleasant tingling sensations in the limbs, numbness and goosebumps).
Healthy kidneys will try to remove excess drug, but when their function decreases, extremely unpleasant symptoms can occur:
- nausea and vomiting;
- hypotension;
- respiratory disorders;
- anuria;
- numbness of the limbs.
Severe cases of overdose are life-threatening. Respiratory paralysis or cardiac arrest may occur. Of course, these are isolated cases caused by an individual body's response to the drug in combination with the inability of the kidneys to excrete it due to a decrease in their function. Nevertheless, the manufacturers of magnesium preparations warn that this is possible.
After cases of overdose, the drugs should not be taken further.
Not everyone is ready to take pills. First, it's inconvenient. Secondly, it contains additional ingredients, including artificial additives. Thirdly, there is an opinion that the body, accustomed to working at the expense of drugs, begins to be lazy to work on its own over time (not quite, of course, but it does not do it as efficiently as it could). Therefore, replacing the tablets with natural products containing the necessary nutrients is a very sensible decision.
However, this is not possible in all cases. If a small deficiency is identified, then, of course, a change in diet can restore the level of this substance. If the shortage is critical, then, most likely, you still have to resort to taking Magnesium B6. In addition, sometimes the problem lies not in improper nutrition, but in the increased excretion of magnesium by the body. For example, this can happen as a result of treatment with hormonal drugs. They are able to reduce the level of macronutrient, along with the level of potassium, to a critical level and provoke the development of serious cardiovascular diseases. With hormone therapy, you should immediately start taking the supplement in the form of pills, since even the diet that is maximally saturated with this microelement will not be able to maintain its level in the norm.
If the treatment of food deficiency is possible, then the diet must include in large quantities:
- nuts (all types);
- sunflower seeds;
- beans;
- green pea;
- lentils;
- buckwheat, oat and millet groats;
- parsley and dill;
- garlic;
- carrot;
- spinach;
- arugula;
- banana;
- raisin;
- persimmon;
- dates;
- prunes;
- eggs;
- a fish;
- milk and dairy products;
- meat (pork and beef).
Analogs and generics
It's no secret that the pharmaceutical market offers drugs with the same composition at different prices. These medicines have different names and are produced by different manufacturers. As for magnesium preparations, there are also several of them. Here are just a few of them: Magnesium B6, Magne B6, Panangin, Asparkam, Magnerot, Magnelis B6 forte, Magnistad, etc.
Video: an overview of magnesium preparations
If a person wants to maintain health, then he must ensure that his body, in addition to other useful substances, receives magnesium B6. With a deficiency of this trace element, it is necessary to adjust the diet or even resort to taking special medications. However, you do not need to take them thoughtlessly, since an overdose is no less dangerous for the body than a lack of this substance. The opinion that everything superfluous will simply be excreted by the body without causing any harm is erroneous. In order not to harm yourself, you need to carefully approach the calculation of the dosage, monitor the body's reaction to taking medications, and consult a doctor.
A.S. Kadykov
Professor
S.N. Busheneva
doctor
The name "magnesia" is already found in the Leiden X papyrus (3rd century AD). It probably comes from the name of the city of Magnesia in the highlands of Thessaly. Magnesian stone in ancient times was called magnetic iron oxide, and magnes - a magnet. It is interesting that the original name "magnesium" was preserved only in Russian thanks to the textbook of Hess, and at the beginning of the 19th century, other names were proposed in a number of manuals - magnesia, magnesia, bitter earth.
The total magnesium content in the human body is about 25 grams. It plays an important role in the formation of over three hundred enzymes. Magnesium takes part in energy and electrolyte metabolism, acts as a regulator of cell growth, is necessary at all stages of the synthesis of protein molecules. The role of magnesium in the processes of membrane transport is especially important. Magnesium helps to relax muscle fibers (musculature of blood vessels and internal organs). The most important value of magnesium is that it serves as a natural anti-stress factor, inhibits excitation processes in the central nervous system and reduces the body's sensitivity to external influences.
It is believed that 25-30% of the population lacks magnesium from their diet. This may be due to modern processing technologies and the use of mineral fertilizers when growing vegetables, leading to a deficiency of magnesium in the soil.
Chronic magnesium deficiency is often observed in patients with diabetes mellitus, arterial hypertension, atherosclerosis, epilepsy, osteoporosis, etc. A number of physiological conditions are known, accompanied by an increased need for magnesium: pregnancy, breastfeeding, a period of intensive growth and maturation, old and senile age, hard physical labor and physical activity in athletes, emotional stress, frequent and prolonged (more than 30-40 minutes. session) staying in the sauna, not getting enough sleep, air travel and crossing time zones. Magnesium deficiency occurs when taking caffeine, alcohol, drugs, and certain medications, such as diuretics, that help remove magnesium in the urine.
Our nervous system is sensitive to magnesium levels in the body. Its reduced content can cause anxiety, nervousness, fear, as well as insomnia and fatigue, decreased attention and memory, in some cases - seizures, tremors and other symptoms. People often complain of "unreasonable" headaches.
Magnesium (especially in combination with vitamin B6) has a normalizing effect on the state of the higher parts of the nervous system during emotional stress, depression, neurosis. This is no coincidence. Stress (physical, mental) increases the need for magnesium, which causes intracellular magnesium deficiency.
Magnesium deficiency worsens with age, reaching a maximum in people over 70. According to the European Epidemiological Study of Cardiovascular Diseases, plasma magnesium levels below 0.76 mmol / L are considered an additional (for example, hypertension) risk factor for stroke and heart attack. An imbalance of Ca2 + and Mg2 + ions is one of the serious causes of blood clots in blood vessels. The use of magnesium preparations helps to reduce the tendency to form a blood clot. Magnesium, for example, enhances the antithrombotic effect of aspirin.
It is believed that magnesium plays a positive role in inhibiting the process of atherosclerosis.
Taking into account the latest data on the prevalence of magnesium deficiency in residents of large cities, its content in the blood is determined in neurological patients with chronic fatigue syndrome, vegetative-vascular dystonia, as well as in depression and asthenia. Normally, the serum magnesium content in children varies from 0.66 to 1.03 mmol / l, in adults from 0.7 to 1.05 mmol / l.
In healthy people, the daily requirement for magnesium is 350-800 mg. In case of magnesium deficiency, its additional administration is required at the rate of 10-30 mg per kilogram of body weight per day. In addition to dietary correction, medicinal preparations are also used. The saturation time of tissue depots during magnesium therapy is 2 months or more. The choice of drugs for correction is well known - these are inorganic and organic magnesium salts. The first generation of magnesium-containing preparations included inorganic salts. However, in this form, magnesium is absorbed by no more than 5%, stimulates intestinal motility, which often leads to diarrhea. The absorption of magnesium in the gastrointestinal tract is increased by lactic, pidolic and orotic acids, vitamin B6 (pyridoxine), and some amino acids.
The second generation of magnesium-containing preparations is much better absorbed and does not cause dyspepsia and diarrhea. Magne-B6 belongs to modern combined drugs.
The anti-anxiety effect of Magne-B6 allows it to be included in the complex therapy of depression (in conjunction with antidepressants), convulsive conditions (in combination with anticonvulsants), sleep disorders (in conjunction with hypnotics), and also to use the drug as an additional means to prevent and level excitatory lungs. the effects of activators of brain metabolism. Magnesium therapy is a rather promising direction in the treatment of night sleep disorders of various origins, especially in patients with asthenic and anxiety conditions. The vasodilating effect of magnesium ions allows Magne-B6 to be used in combination with antihypertensive agents. However, a decrease in blood pressure in response to magnesium administration is achieved only in patients with magnesium deficiency.
O.A. Gromova1,2, A.G. Kalacheva1,2, T.E. Satarina1,2, T.R. Grishina1,2, Yu.V. Mikadze3, I. Yu. Torshin2,4, K.V. Rudakov4
1GOU HPE "Ivanovo State Medical Academy" of Roszdrav
2Russian Collaborating Center of the UNESCO Trace Element Institute
3Faculty of Psychology, GOU VPO Moscow State University M.V. Lomonosov
4Laboratory of Computational and Systems Biology, Computing Center named after A.A. Dorodnitsin RAS
Introduction
The stress state of the body, in general, corresponds to the imbalance between external conditions and the body's ability to adequately respond to them. Systematic dissatisfaction with the results of social activity, restraint of emotional manifestations, due to social norms of behavior, often lead to the fact that a modern person often experiences a lack of peace of mind, emotional balance, along with a gradual loss of efficiency at work and the emergence of chronic diseases.
The analysis of stress conditions is one of the topical directions in the study of unfavorable functional states of a modern person. Assessment and enhancement of the body's adaptive capabilities is considered as one of the important criteria for health. The higher the adaptive capacity of the body, the lower the risk of disease, since the more reliable protection against disease. Any type of stress can be viewed as a source of “labor distress”, given its negative effect on performance and the development of personal maladjustment and mental health problems. The process-cognitive paradigm understands stress as a process of actualizing the repertoire of internal means of overcoming difficulties. The basic stress models include the two-factor demand-control model and the hormonal model.
In particular, stress during intensive learning can be seen as the result of an imbalance between the requirements of the learning environment and human resources, including subjective assessment. The curriculum of 3rd year students of medical universities is characterized by information overload, especially during the examination session. High emotional and intellectual stress during the pre-examination and examination periods can be considered as an adequate model of professional stress for young people who are able to work and apply methods for assessing professional stress in students. In this work, we investigated the effect of magnesium in synergistic combination with pyridoxine on the ability of students to adapt under conditions of increased stress. For the study of antistress activity, Magne B6 drug produced by the French company Sanofi-aventis was used.
Materials and methods
Sample of students. 89 students of the 3rd year of IvSMA voluntarily took part in the research. In the selection process, the volunteers were divided into 2 groups: the study (first) group of 58 people and the control (second) group of 31 people. Students in the first group received Magne B6 therapy, 2 tablets 3 times a day (daily dose of magnesium - 288 mg, calculated as pure magnesium, pyridoxine - 30 mg) for 2 weeks, then - 2 tablets 2 times a day (daily dose magnesium - 192 mg, pyridoxine - 20 mg) for 6 weeks. Students in the second group (control) did not take any special drugs.
The average age of students in the study group was 20 years (19-25 years old), in the control group - 21 years (19-25 years old). In the study group, women accounted for 72% of the total number of surveyed students, men - 28%; the control group had a similar sex ratio (67% of women, 33% of men). The average body weight of students in both groups was 56.79 ± 3.46 kg for women and 72.8 ± 5.1 kg for men.
The criteria for exclusion from the study were the presence of severe, acute and chronic somatic, mental illnesses, taking any medications and dietary supplements. The study complied with the ethical standards of biomedical ethics committees developed in accordance with the Declaration of Helsinki as amended in 2000 and the Rules of Clinical Practice in the Russian Federation (1993). All students gave written informed consent to participate in the study.
Survey protocol. Each study participant underwent examination under the protocol twice. The first survey was carried out before the start of the study and the second at the end of the study (after 8 weeks). Statistically significant differences between students of the first and second groups were assessed in dynamics - day "0", day "60". According to the protocol, the following were assessed and analyzed:
Individual registration cards (CRF) containing medical and demographic (age, sex), anthropometric (height, body weight) characteristics, data on health status, information on social and labor status, attitudes towards smoking.
The level of magnesium and pyridoxine deficiency, assessed by testing using a structured questionnaire.
The level of students' stress exposure using the IDIX methodology of integrated diagnostics and correction of professional stress, presented in the form of a structured questionnaire of 6 main scales and formed in accordance with the hierarchical scheme of stress analysis. A brief description of this technique is given in Table 1. According to the IDIX scale, the manifestations of acute stress were: physiological discomfort, mental and emotional tension, difficulties in communication. Chronic stress was additionally characterized by asthenia, sleep disturbances, anxiety, depressive states, and aggression.
Personal and behavioral deformations, assessed by the presence of signs of burnout syndrome (apathy, complete lack of interest in work and study), neurotic reactions, shocking or excessive withdrawal.
The state of various types of memory, for which the diagnosis of the general state of auditory-speech, visual and motor memory was carried out using a neuropsychological diagnostic technique using the DIAKOR program, developed at the Faculty of Psychology of Moscow State University. This made it possible to answer the question about the weakest links of the corresponding types of memory, such as the basic mental process that influences the manifestation of other mental functions when exposed to occupational stress.
For the statistical processing of the research results, the methods of mathematical statistics were used, including the calculation of the numerical characteristics of random variables, testing statistical hypotheses using parametric and nonparametric criteria, correlation, analysis of variance. The method of visual comparison of 95% confidence intervals was also used to test statistical hypotheses about the difference in the mean values of features. The confidence intervals were estimated using the binomial distribution. To designate the boundaries of the 95% confidence interval of relative values, the symbol "#" was used, separating the upper and lower bounds of the 95% confidence interval of the true mean value of a random variable. Comparison of predicted and observed frequencies of occurrence of signs was carried out using the Chi-square test. To compare the dependent variables, the most accurate Wilcoxon-Mann-Whitney T-test was used in medical research (which, as you know, is not limited to a certain form of distribution of a random variable). For statistical processing of the material, the STATISTICA 6.0 application program was used. Confidence levels were calculated; the values of P
Results and discussion
There were no statistically significant differences in the age, gender or body weight of students in both groups (p> 0.05). Table 2 shows the analysis of the incidence of diseases among the examined students. An analysis of the incidence rates of individual diseases registered in students in the IRC showed that the most frequent in students of both groups are diseases of the gastrointestinal tract, cardiovascular diseases. For all diseases, there were no statistically significant differences in the incidence of individual diseases between groups 1 and 2 (p> 0.05).
The homogeneity of the study groups was also analyzed by means of Spearman pair correlation. In both groups on day "0" there was a clear correlation between levels of magnesium deficiency and parameters on the IDIX scale. Thus, correlations were found between the level of magnesium deficiency and conditions and work organization (R
1. Exposure to stress
Indicators of the general stress level in the study groups on day "0" practically did not differ and the general stress index on the IDIX scale ("V0" in Table 3) corresponded to a high level (58.1 in the study group and 55.3 in the control group) ... On day 0, the following characteristics of professional stress could be distinguished among students in both groups:
External circumstances hindering the activity (poor working conditions, problems in the organization of the labor process and high intensity of work);
strengthening of inadequate forms of stress relief: smoking, alcohol consumption;
Demonstration of hostile behavior characteristic of magnesium deficiency.
When comparing the assessment of professional stress among students of the initial level (day "0") and 2 months later (day "60") in the control group (second group), the subjective assessment of the professional situation significantly worsened (during the observation period, the load in the semester increased, the examination session) (p = 0.021). The deterioration was accompanied by signs of psychological exhaustion - emotional tension, a decrease in general well-being, an increase in anxiety, signs of depression and sleep disturbances.
At the same time, in the study group receiving Magne B6 therapy, despite the increase in stress in studies and preparation for the session, the test index of the subjective assessment of the professional situation did not significantly change (which corresponds to the supportive effect of the drug). In addition, Magne B6 therapy significantly reduced the severity of experiences of acute and chronic stress (p = 0.022 and 0.001, respectively), which was manifested in an improvement in general well-being, mood, concentration, and recall of the necessary information. In the control group, the level of chronic stress also decreased, albeit not significantly (we believe that this is a response to the use of a placebo and an element of retention of some test questions in memory).
Most importantly, taking the drug Magne B6 led to a decrease in the severity of stress reactions. The general IDIX stress index in this group also significantly decreased (p = 0.001), while in the control group it increased. In addition, Magne B6 therapy significantly (by 30%) reduced the manifestations of personality behavioral deformities (p = 0.00001), ie, reduced the signs of burnout and neurotic reactions (see Table 3). The students have improved indicators of the autonomy of task execution (independence). The most significant differences are summarized in Fig. 1.
2. Functioning of memory
The DIACOR scale was used to assess the parameters of auditory-speech, visual and motor memory. On this scale, memory functioning was assessed in inverse proportion to the number of so-called. "Penalty points", ie, the lower the score, the more efficiently the memory operates. In almost all parameters of all three types of memory, significant improvements were observed in the group taking Magne B6, compared with the control.
a) When assessing the parameters of hearing-speech memory on day "60", students of both groups improved the integral indicator of hearing-speech memory (p 6) by the end of the course of treatment, the changes were higher than in the control group: the integral indicator of memory on the DIACOR scale improved by 2.55 versus 2.42 times, respectively (P 6, the best results were obtained for combining various stimuli into integral semantic structures, i.e., the ability to analyze and synthesize information. decreased from 1.16 to 1.02 (R b) When assessing the parameters of visual memory on day "0" in the comparison groups, no significant changes were found (p> 0.05). On day "60", students in the control group showed an improvement the volume of direct visual memory on the IDIX scale (p = 0.05), other parameters did not change significantly (Table 4).
At the same time, in the group of students who took Magne B6, the data obtained on day 60 indicate a pronounced and, most importantly, significant improvement in the integral indicator of visual memory (5.4 times, p c). on day "0" and dynamic assessment of parameters in the second group (control), significant changes were not revealed (p> 0.05). The students of the study group significantly improved the integral indicator of motor memory (p = 0.0035, 2.3 times versus 1.9 times compared with the control group) due to a significant increase in the volume of immediate memory (5 times, p = 0.014) ( Table 5).
Differences in the integral indicators of various types of memory are summarized in Fig. 2.
Thus, the course administration of Magne B6 improves the parameters of visual, auditory-speech and motor memory. Improving the parameters of both visual and auditory memory correlates with the optimization of the work of the posterior structures of the left hemisphere, the anterior structures of the left hemisphere, the posterior regions of the right hemisphere and the anterior regions of the right hemisphere. At the same time, by improving the indicators of motor memory, the drug probably affects the functioning of the brain structures that provide interhemispheric interaction.
3. Assessment of magnesium and vitamin B6 levels
Students of both groups had approximately the same level of magnesium deficiency and hypovitaminosis B6 on day "0". A two-month course of application of the vitamin-mineral complex Magne B6 significantly reduced the total score of magnesium deficiency (p = 0.000001) and vitamin B6 (p = 0.00003), which corresponds to a significant improvement in the supply of magnesium and pyridoxine, while in the control group there was practically no changes in indicators are observed (Fig. 3).
Another interesting observation that directly testifies to the normalization of magnesium homeostasis was a significant decrease in calf muscle cramps in the study group (p 6 and 19.35% (6 of 31) in the control group complained of “flattening” of the calf muscles or foot muscles during swimming or after the pool, as well as after training in the gym On day 60, in the control group, the number of students who complained of leg cramps not only did not decrease, but increased to 25.8% (8 out of 31), while as in the group of students who took Magne B6, seizures were not observed in any student (Fig. 4).
conclusions
Thus, against the background of the course intake of the drug Magne B6, it was noted:
1. a significant reduction in the signs of magnesium deficiency and hypovitaminosis B6;
2. improvement of indicators of auditory-speech, motor and visual memory;
3. Reducing the experience of acute and chronic stress, reducing personality and behavioral deformities, improving muscle performance.
These results indicate that the 60-day course of Magne B6 is an effective way of pharmacological correction of magnesium and vitamin B6 deficiency, which manifested itself in a significant improvement in cognitive functions and, above all, memory and a decrease in negative manifestations of stress at high psycho-emotional stress.
Gratitude. We are very grateful to Asp. I.V. Gogoleva, Assoc. O.A. Nazarenko, staff of the department V.A. Abramova, A.S. Murin for help in conducting the clinical trial and Ph.D. A.Yu. Gogolev for his help with mathematical data processing.
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Modern research shows that magnesium is capable, depression, increased irritability and nervousness. It lowers the excitability of the nervous system and enhances the processes of inhibition in the cerebral cortex. And therefore makes us more calm and balanced.
If you're stressed out, eating a green salad or a couple of bananas can help - these treats are high in magnesium. And to quickly fall asleep, wash down a teaspoon of honey with warm milk. It is best if the honey is dark, buckwheat - it has a particularly high magnesium content.
For heart problems
Magnesium deficiency can contribute to the development of many diseases of the cardiovascular system. For example, scientists from Ireland and the USA managed to identify a certain relationship between the development of cardiac arrhythmias and a lack of magnesium in the body.
Magnesium dilates blood vessels, improves the activity of the heart muscle, regulates. This macronutrient promotes the elimination of cholesterol from the intestines, thereby preventing the development of atherosclerosis. Magnesium is also vital for the blood vessels of the brain. So a diet enriched with this substance is an excellent prevention of strokes and migraines. Add dry fruits, fish and wheat germ to the menu.
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