Catad_pgroup Calcium-phosphorus metabolism regulators
Calcium-D3 Orange Nycomed - instructions for use
Registration number:
Trade name of the drug:
Calcium-D 3 Nycomed
Dosage form
Chewable tablets (orange).
Composition for one tablet
Active ingredients:
calcium carbonate - 1250 mg (equivalent to elemental calcium - 500 mg) colecalciferol (vitamin D 3) - 5 μg (200 ME) as a concentrate of colecalciferol 2 mg.
Auxiliary components:
sorbitol, isomalt, povidone, magnesium stearate, aspartame, orange oil, mono- and diglycerides of fatty acids.
Description:
Round, uncoated biconvex tablets of white color with orange flavor. May have small blotches and uneven edges.
Pharmacotherapeutic group:
Calcium-phosphorus metabolism regulator.ATX code: A12AX
pharmachologic effect
Combined drug that regulates the exchange of calcium and phosphorus in the body (bones, teeth, nails, hair, muscles). Reduces resorption (resorption) and increases bone density, replenishing the lack of calcium and vitamin D 3 in the body, which is necessary for the mineralization of teeth. Calcium is involved in the regulation of nerve conduction, muscle contractions and is a component of the blood coagulation system.
Pharmacodynamic properties
Vitamin D increases intestinal absorption of calcium.
The use of calcium and vitamin D 3 prevents an increase in the production of parathyroid hormone (PTH), which is a stimulator of increased bone resorption (leaching of calcium from the bones).
Pharmacokinetic properties
Vitamin D 3 is absorbed in the small intestine. Calcium is absorbed in ionized form in the proximal small intestine through an active, D-vitamin dependent transport mechanism.
Indications for use
The drug is in dosage form - tablets are not used in children under the age of 3 years. Use with caution: pregnancy, lactation period. Application during pregnancy and lactation
The daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D 3.
Hypercalcemia that develops against the background of an overdose during pregnancy can cause defects in the mental and physical development of the child.
Vitamin D and its metabolites can pass into breast milk, therefore, it is necessary to take into account the intake of calcium and vitamin D from other sources in the mother and child. Method of administration and dosage
Adults: in the treatment of osteoporosis - 1 tablet 2-3 times a day, for the prevention of osteoporosis - 1 tablet 2 times a day. With a deficiency of calcium and vitamin D:
Adults and children over 12 years old - 1 tablet 2 times a day. Children from 5 to 12 years old: 1-2 tablets per day.
Children from 3 to 5 years old - dosage in accordance with the doctor's recommendations. Tablets can be chewed or sucked and taken with meals. Side effect
Allergic reactions, dysfunction of the gastrointestinal tract (constipation or diarrhea, flatulence, nausea, abdominal pain), hypercalcemia and hypercalciuria (increased calcium in the blood or urine). Overdose
Overdose symptoms: anorexia, thirst, polyuria, loss of appetite, dizziness, fainting, weakness, nausea, vomiting, hypercalciuria, hypercalcemia, hypercreatinemia. With prolonged use of excessive doses, vascular and tissue calcification. Treatment: the introduction of a large amount of fluid into the body, the use of loop diuretics (for example, Furosemide), glucocorticosteroids, calcitonin, bisphosphonates.
If you find signs of overdose, seek medical attention. If clinical symptoms of an overdose develop, the concentration of calcium and creatinine in the blood should be determined. In the case of an increased concentration of calcium or creatinine in the blood serum, the dose of the drug should be reduced or the treatment should be temporarily discontinued.
In case of hypercalciuria exceeding 7.5 mmol / day (300 mg / day), it is necessary to reduce the dose or stop taking it. Interaction with other medicinal products
Chewable tablets of 20, 50 or 100 tablets in a high density polyethylene bottle, sealed with a screw cap, under which there is a ring for tearing off the sealing gasket, which provides control of the first opening. Part of the label is attached to the bottle with a special adhesive tape that allows the label to be lifted. The instructions for use in the form of a folding sheet are placed under the movable part of the label. Shelf life
3 years
Do not use after the expiration date. Storage conditions
Store the bottle tightly closed at a temperature not exceeding 25 ° C in a dry place. Keep out of the reach of children! Terms of dispensing from pharmacies
Without a doctor's prescription Manufacturer
Nycomed Pharma AS, Norway. Manufacturer's address
Nycomed Pharma AS
Drammensveien 852, N-1385 Asker, Norway
Nycomed Pharma AS
Drammensveien 852 N-1385 Asker, Norway Representative office in Russia / CIS:
119049 Moscow, st. Shabolovka, 10
In this article, you can read the instructions for the use of the medicinal product. Calcium D3 Nycomed... The reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Calcium D3 Nycomed in their practice are presented. A big request to more actively add your reviews about the drug: did the medicine help or did not help get rid of the disease, what complications and side effects were observed that may not have been declared by the manufacturer in the annotation. Analogues of Calcium D3 Nycomed in the presence of available structural analogs. Use for the treatment of calcium deficiency and the prevention of osteoporosis in adults, children, as well as during pregnancy and lactation.
Calcium D3 Nycomed- a combined preparation that regulates the exchange of calcium and phosphorus in the body (in bones, teeth, nails, hair, muscles).
Reduces resorption (resorption) and increases bone density, replenishing the lack of calcium and vitamin D3 in the body, which is necessary for the mineralization of teeth.
Calcium is involved in the regulation of nerve conduction, muscle contractions and is a component of the blood coagulation system.
Vitamin D3 (cholecalciferol) increases intestinal absorption of calcium.
The use of calcium and vitamin D3 prevents an increase in the production of parathyroid hormone, which is a stimulant of increased bone resorption (leaching of calcium from the bones).
Pharmacokinetics
Vitamin D3 is absorbed in the small intestine.
Calcium is absorbed in ionized form in the proximal small intestine through an active vitamin D-dependent transport mechanism.
Composition
Colecalciferol (vitamin D3) + calcium carbonate + excipients.
Indications
- prevention and treatment of calcium and / or vitamin D3 deficiency (vitamin deficiency, hypovitaminosis);
- prevention and complex therapy of osteoporosis (including menopausal, senile, steroid, idiopathic).
Forms of issue
Chewable tablets.
Chewable tablets Calcium D3 Nycomed forte (increased dose of vitamin D3).
Instructions for use and reception scheme
Adults in the treatment of osteoporosis are prescribed 1 tablet 2-3 times a day, for the prevention of osteoporosis - 1 tablet 2 a day.
With a deficiency of calcium and vitamin D, adults and children over 12 years of age are prescribed 1 tablet 2 per day, children aged 5 to 12 years - 1-2 tablets per day, children aged 3 to 5 years, the dosage regimen is set individually.
The tablet can be chewed or sucked and taken with meals.
Side effect
- constipation;
- diarrhea;
- flatulence;
- nausea;
- stomach ache;
- hypercalcemia;
- hypercalciuria;
- allergic reactions.
Contraindications
- hypercalcemia;
- hypercalciuria;
- nephrolithiasis;
- hypervitaminosis D;
- severe renal failure;
- active form of tuberculosis;
- sarcoidosis;
- children under the age of 3;
- hypersensitivity to the components of the drug.
Application during pregnancy and lactation
Caution should be exercised when prescribing the drug during pregnancy and lactation.
During pregnancy, the daily dose of the drug should not exceed 1500 mg of calcium and 600 IU of vitamin D3. Hypercalcemia, which develops against the background of an overdose during pregnancy, can cause defects in the mental and physical development of the child.
Vitamin D and its metabolites can be excreted in breast milk, therefore additional intake of calcium and vitamin D from other sources in the mother and child must be considered.
Application in children
Contraindicated in children under 3 years of age.
special instructions
Calcium D3 Nycomed tablets contain aspartame, which is transformed in the body into phenylalanine, so the drug should not be taken with phenylketonuria.
When using the drug Calcium-D3 Nycomed in patients who receive cardiac glycosides and / or diuretics, it is necessary to control the concentration of calcium and creatinine in the blood serum.
In the case of an increased concentration of calcium or creatinine in the blood serum, as well as in the case of hypercalciuria exceeding 7.5 mmol per day (300 mg per day), the dose of the drug should be reduced or the treatment should be temporarily discontinued.
To avoid overdose, additional intake of vitamin D3 from other sources must be considered.
Consumption of foods containing oxalates (sorrel, spinach) and phytin (cereals) reduces the absorption of calcium, so you should not take Calcium-D3 Nycomed within 2 hours after taking sorrel, spinach, cereals.
Calcium-D3 Nycomed should be used with caution in immobilized patients with osteoporosis due to the risk of hypercalcemia.
Drug interactions
With simultaneous use with phenytoin or barbiturates, a decrease in the activity of vitamin D3 is possible.
Calcium preparations can potentiate the therapeutic and toxic effects of cardiac glycosides, therefore, with the simultaneous use of Calcium D3 Nycomed and cardiac glycosides, it is necessary to monitor the ECG and the clinical condition of the patient.
Calcium and vitamin D3 preparations can increase the absorption of tetracyclines from the gastrointestinal tract, therefore, the interval between taking Calcium-D3 Nycomed and antibiotics of the tetracycline group should be at least 3 hours.
With simultaneous use with bisphosphonates or sodium fluoride, their absorption may decrease, therefore it is recommended to take Calcium-D3 Nycomed no earlier than 2 hours after these drugs.
GCS reduce the absorption of calcium, therefore, in patients receiving GCS, an increase in the dose of Calcium-D3 Nycomed may be required.
With simultaneous use with cholestyramine or laxatives based on mineral or vegetable oil, the absorption of vitamin D3 may decrease.
With simultaneous use with thiazide diuretics, the risk of hypercalcemia increases due to an increase in tubular calcium reabsorption. Furosemide and other "loop" diuretics, on the contrary, increase the excretion of calcium by the kidneys.
Analogues of the medicinal product Calcium D3 Nycomed
Structural analogues for the active substance:
- Ideos;
- Calcium + Vitamin D3 Vitrum;
- Calcium D3 Classic;
- Calcium-D3-MIC;
- Complivit calcium D3;
- Complivit Calcium D3 for babies;
- Complivit calcium D3 forte;
- Natekal D3;
- Revital Calcium D3.
In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and see the available analogues for the therapeutic effect.
The effectiveness of medication treatment can be greatly enhanced by fairly simple methods. One of the most accessible is to understand what time it is best to take the medicine, and try to adhere to this particular regimen. For example, when to take calcium in the morning or in the evening is of great importance for bone repair. And about this - right now.
This element plays a vital role in more than just bone health.
Along with this main task, it performs the following functions:
- Provides the process of muscle contraction and thus participates in the heartbeat (the myocardium is the main muscle of the heart that pumps blood through the vessels).
- Provides blood clotting processes, as it enhances the effect of vitamin K, which is involved in these reactions.
- Provides a mechanism for the selective permeability of substances through the membranes (barriers) of cells: some substances pass through it, others do not.
- This element takes part in the process of formation and transmission of impulses through the cells of the nervous system (neurons).
- Participates in metabolic and hormonal processes by activating certain vital chemical reactions in the body.
First of all, medicines containing this element should be used by those people who are at risk:
- suffering from osteochondrosis, arthritis or having prerequisites for their development (for example, hereditary);
- have suffered various fractures and other bone injuries;
- predisposed to colon cancer;
- by gender - women are more susceptible to a lack of this element due to the hormonal characteristics of the body;
- leading an unhealthy lifestyle in terms of an unbalanced diet: an excess of carbonated drinks, sweets, flour products, coffee, alcohol and fatty foods, as well as foods with an excess of salt (chips, pickles for the winter, etc.);
- by age - people over 60 need special care for their bones due to the gradual weakening of bone tissue and salt deposition.
On the other hand, even if a person does not fall into any of these categories, he may, on the recommendation of a doctor, decide to take the appropriate medication, especially if he has some of the following symptoms:
- Unexplained anxiety, irritability, insomnia.
- Frequent numbness in the arms and legs, frequent cramps, involuntary muscle contractions.
- Pain in joints, bones, sore gums.
- Brittle nails.
- Women have unusually heavy menstrual flow.
- Children have severe growth retardation, often a desire to eat chalk.
NOTE
None of the listed signs is an absolutely accurate signal to start taking medications. Before deciding on therapy, you should definitely consult your doctor for advice.
The list of foods rich in calcium (in descending order) is as follows:
- The group of dairy products - cheeses (the record holder for content is parmesan), cottage cheese, sour cream, kefir, yogurt.
PLEASE NOTE - Contrary to popular belief, milk is not the best source of calcium. The fact is that along with this element, its composition includes lactose, which belongs to simple carbohydrates, in excess of damaging bones. A much more suitable product is cheese, which contains no lactose at all.
- Greens and some vegetables: all types of cabbage, parsley, spinach, dill.
- Almost all nuts, especially almonds and Brazil nuts.
- Sesame and poppy seeds.
- Whole grain flour (there is no calcium in the premium flour).
- Soy and products based on it.
- Molasses is a great option for those with a sweet tooth. If you replace sugar with molasses, the benefits for the body are twofold: it will be saturated with calcium, and on the other hand, it will avoid the harmful effects of excess sugar.
NOTE
You should not focus on only one of the products - food should be varied. In addition, the constant use of monotonous food has a bad effect on the condition of the gastrointestinal tract.
Oddly enough, in the medical community there is no unambiguous and clear answer to the question of when it is better to take calcium-containing drugs (for example, calcium d3 nycomed). Therefore, one should not expect unambiguous recommendations on this score.
Nevertheless, there are several simple rules, the observance of which is guaranteed to increase the effect of therapy due to a more complete absorption of the components:
- Since there are equally opinions that you can take calcium during the day and you can drink it in the evening, the most correct option is to split the dose into at least 2 parts and take it, like most other drugs: in the morning and in the evening. Or divided into three parts and taken in the morning, lunch and evening. At the same time, it has been proven that frequent intake in small portions is much more effective than a single large portion - it will not be absorbed in full.
- A fundamentally important point, at which many make a mistake, as a result of which the intake of calcium-containing preparations turns out to be virtually meaningless: they use these drugs only in conjunction with those substances that contribute to its absorption by the bone tissue. These are vitamin D, food and preparations containing phosphorus and magnesium - these elements in themselves are beneficial and enhance the effect of calcium.
PLEASE NOTE - Vitamin D is found in beef liver, sour cream, egg yolk, fish oil, herring, and especially a lot of it in the liver of any type of marine fish. All nuts, sunflower seeds, beans, green apples, green bell peppers are rich in magnesium. Phosphorus is found in dairy products, meat and poultry, eggs, fish, walnuts, and oatmeal.
- Along with the fact that it is important to know when is the best time to drink calcium, its combination with food plays an equally significant role. It is important to take the medication only after a light, low-fat meal. And do not take them in combination with some organic acids (oxalic and phytic) - accordingly, do not eat sorrel, spinach, beets in parallel.
- The dosage form of the drug is important. If it is possible to purchase a medicine in the form of a liquid or powder, it is better than tablets.
- However, among the tablets, there are also different variations - from traditional to chewable and effervescent. The latter type is the best, it is absorbed most fully and quickly.
- In the instructions for the preparation, it is imperative to clarify in what form the calcium is contained, i.e. what active substance is the basis of this medicine. Calcium carbonate is well absorbed with or immediately after meals. And calcium gluconate, lactate and citrate (organic forms) are assimilated regardless of food and time of day.
- Finally, like most other medicines, calcium medicines are always taken with an excess of 1-2 cups of liquid.
Thus, the effectiveness of taking calcium-containing preparations, first of all, depends not on what time of day it is better to take them, but on the following factors:
- combination with certain food;
- a combination with drugs that promote the absorption of calcium and its most complete assimilation by bone tissue;
- chemical (dosage form of the drug).
Therefore, the question of at what time of day calcium is better absorbed can be largely replaced by the question: in combination with what drugs and food, this element brings more benefits.
NOTE
Before taking calcium, it is imperative to consult a doctor to avoid possible side effects associated with the characteristics of a particular organism. In any case, long-term, over 6-12 months (or over several years) calcium intake can lead to the formation of kidney stones.
Thus, calcium is one of the vital elements that the body cannot do without. And it is important to take medications containing it only on the basis of the above rules. Otherwise, the effect of therapy will be virtually zero.
Calcium-D3 Nycomed is a mineral supplement that regulates the exchange of calcium and phosphorus.
Release form and composition
Dosage form of the drug - chewable tablets:
- Orange - in high density polyethylene bottles of 20, 50 or 100 pcs., 1 bottle in a cardboard box;
- Mint - in high density polyethylene bottles of 30 or 100 pcs., 1 bottle per package.
Active ingredients:
- Calcium carbonate - 1250 mg (which corresponds to 500 mg of elemental calcium);
- Colecalciferol (vitamin D3) - 5 mcg (200 IU).
Excipients of tablets:
- Orange - povidone, sorbitol, isomalt, magnesium stearate, aspartame, mono- and diglycerides of fatty acids, orange oil;
- Mint - sorbitol, povidone, magnesium stearate, aspartame, mint flavor.
Indications for use
- Deficiency treatment and prevention of calcium and / or vitamin D3 deficiency;
- Prevention and treatment (as part of complex therapy) of osteoporosis and its complications.
Contraindications
- Hypercalciuria;
- Hypercalcemia;
- Severe renal failure;
- Nephrolithiasis;
- Hypervitaminosis D;
- Active form of tuberculosis;
- Sarcoidosis;
- Children under 3 years old;
- Phenylketonuria;
- Hereditary fructose intolerance, glucose-galactose malabsorption and sucrase-isomaltase deficiency;
- Hypersensitivity to the components of the drug, soy or peanuts.
Patients with renal insufficiency, pregnant and lactating women should be under constant supervision during the treatment period.
Method of administration and dosage
The drug should be taken with meals, the tablets must be dissolved or chewed until completely dissolved.
- To replenish the lack of calcium and vitamin D: children over 12 years old and adults - 1 tablet twice a day, children 5-12 years old - 1-2 tablets a day, children 3-5 years old - as prescribed by a doctor;
- For the prevention of osteoporosis: adults - 1 tablet twice a day;
- As part of the complex therapy of osteoporosis: adults - 1 table. 2-3 times a day.
As a remedy for the deficiency of calcium and vitamin D3, the drug is taken in courses of at least 4-6 weeks, the number of courses during the year is determined individually.
As a means intended for the prevention and treatment of osteoporosis, the duration of the use of a mineral supplement is determined by the doctor individually for each patient.
Side effects
Basically, Calcium-D3 Nycomed is well tolerated, in rare cases, the following side effects are noted:
- Digestive system: abdominal pain, flatulence, constipation or diarrhea, nausea, indigestion;
- Metabolism: hypercalciuria and hypercalcemia;
- Skin and subcutaneous tissue: rash, itching, urticaria.
An overdose of calcium is fraught with the development of hypercalcemia, its symptoms: thirst, muscle weakness, abdominal pain, constipation, nausea, vomiting, polyuria, fatigue, anorexia, bone pain, urolithiasis, nephrocalcinosis, mental disorders. In severe cases, cardiac arrhythmias are added. With prolonged use in excessive doses (more than 2500 mg of calcium), kidney damage and calcification of soft tissues are possible. If any of the described symptoms appear, you should stop taking Calcium-D3 Nycomed and consult a doctor. First aid for overdose involves gastric lavage, then a loop diuretic (for example, furosemide), glucocorticosteroid, calcitonin and bisphosphonates are prescribed, and the replacement of lost fluid is also indicated. It is necessary to monitor urine output, renal function and electrolyte levels in the blood, in severe cases, ECG monitoring and measurement of central venous pressure are required.
Hypercalcemia resulting from an overdose during pregnancy can have an adverse effect on the fetus.
special instructions
In order to prevent an overdose, it is necessary to take into account the intake of vitamin D3 and calcium from other sources, and when taking a mineral supplement during lactation - not only in the mother taking Calcium-D3 Nycomed, but also in the child.
With long-term treatment, it is necessary to control the content of creatinine and calcium in the blood, especially in the elderly who take diuretics and cardiac glycosides, and in patients at risk of kidney stones. If signs of hypercalcemia or renal dysfunction appear, the dose of Calcium-D3 Nycomed should be reduced or stopped altogether.
When prescribing the drug to patients with renal insufficiency, the risk of developing soft tissue calcification should be taken into account. In the process of treatment, it is necessary to control the content of phosphates and calcium in the blood serum.
The drug can be used during pregnancy. However, it should be borne in mind that the daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3.
The supplement should be used with caution in immobilized patients with osteoporosis. they are at high risk of developing hypercalcemia.
Calcium-D3 Nycomed does not have a negative effect on the speed of reactions and the ability to increase concentration of attention.
It is important to know that foods containing oxalates (spinach, sorrel, rhubarb) and phytin (cereals) reduce calcium absorption, so Calcium-D3 Nycomed should not be taken within 2 hours of consuming them.
Drug interactions
It is not recommended to take the drug simultaneously with tetracycline antibiotics and quinolone, since their absorption is reduced. If such a combination is still necessary, it is recommended to take these funds 2 hours before or 4-6 hours after taking Calcium-D3 Nikomed. The entire period of treatment, the patient must be under close medical supervision.
Hypercalcemia resulting from the intake of a mineral supplement can potentiate the toxic effects of cardiac glycosides. It is necessary to control the concentration of calcium in the blood serum and monitor the ECG.
Calcium absorption is reduced by glucocorticosteroids, so an increase in the dose of the supplement may be required.
Calcium reduces absorption and reduces the effectiveness of levothyroxine, so the interval between their intake should be at least 4 hours. Bisphosphonates, if necessary, are recommended to be taken no later than 1 hour before taking Calcium-D3 Nikomed.
The risk of developing hypercalcemia increases with the simultaneous use of thiazide diuretics. In this case, it is necessary to regularly monitor the concentration of calcium in the blood serum.
Terms and conditions of storage
Store in a tightly closed bottle in a dry place, out of reach of children, at temperatures up to 25 ºС.
Shelf life is 3 years.
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