Candid cream for external use during pregnancy. Candide: a medicine for the fungus. Preventive actions on the skin of the face

Candide: instruction

The instruction accompanies any form of release of the drug Candide by applying information directly to the packaging of the drug.

Form, composition, packaging

Several dosage forms are inherent in Candide.

Cream Candide for external use in the form of a homogeneous substance in aluminum tubes with a volume of 20 grams. White colour.

Clotrimazole, being an active component of the composition of the drug, is supplemented with white petrolatum, sodium dihydrate dihydrogen phosphate, propylene glycol, sodium hydrogen phosphate, acrogol emulsion wax, benzyl alcohol, liquid paraffin, methyl parahydroxybenzoate, butylhydroxytoluene, propylene benzoate and purified water.

Powder Candide for external use as a powder in a plastic bottle of thirty grams.

Solution Candide transparent, applied locally with a viscous consistency and colorless. The drug is packaged in bottles with 15 grams of the product. The active ingredient of the composition, clotrimazole, is supplemented with glycerol and propylene glycol in the required proportions.

Candide tablets / suppositories for intravaginal use. Clotrimazole in their composition is combined with the addition in the form of a combination of purified talc, sodium carboxymethyl starch, starch, methyl parahydroxybenzoate, magnesium stearate, propylparaben, silicon dioxide and lactose.

Storage term and conditions

Candide in any of its varieties is stored for about three or four years away from children in a temperature range of 2 to 25 degrees.

Pharmacology

The drug is capable of manifesting a local antifungal (in a wide range) and antibacterial, as well as antiprotozoal action. Demonstrates excellent effect against gram (+) bacteria and a range of gram (-) pathogens. The drug is active against the causative agent of multi-colored lichen.

Pharmacokinetics

The process of metabolism of clotrimazole is carried out in the liver.

Since the application externally does not lead to absorption, systemic action is not observed.

The drug administered intravaginally is absorbed by no more than 10%. The next two or three days after application, a small level of clotrimazole concentration in the blood and a rather high level in the secretion of the vagina may be noted.

Candid indications for use

For a number of diseases, it is advisable to use some forms of Candida:

  • in the presence of pityriasis or multicolored lichen;
  • fungal diaper dermatitis;
  • mycosis of skin folds and feet;
  • the development of candidiasis in the genital area and the posterior passage;
  • erythrasma;
  • with candidiasis paronychia;
  • with candidiasis of superficial etiology, which are caused by various fungi and dermatophytes;
  • with candidiasis of the skin;
  • with mycoses with the subsequent complication of pyoderma;
  • with balanitis or vulvitis candidiasis.

In the form of a solution, the drug is used for the development of candidal stomatitis in the oral cavity.

Vaginal tablets are used in the treatment of candidal infections and superinfections of the genital area.

Often, the drug is used in preparing a woman for childbirth to sanitize the birth canal.

Contraindications

If a patient has a high degree of sensitivity to the active ingredient of the drug, it cannot be treated with this drug, regardless of its form. Also, appointments are not carried out during menstruation and in the first period of pregnancy. Caution is prescribed in the use of the drug for lactating women.

Candid instructions for use

Preparation in the form of a cream

The cream is applied in a thin even layer to the previously cleaned and dried affected surface of the skin cover with soap. Rub in lightly. Apply two or three times a day. The duration of therapy is determined by the doctor.

Dermatomycosis is treated for at least a month, and depriving the pityriasis is enough for a week's use (in severe cases, it will take three weeks). Those who suffer from fungus on the feet after the symptoms disappear should continue to apply the cream for at least two weeks.

Candide solution

This type of drug is prescribed for the treatment of large areas of lesions on the skin or head under the hair. Strict adherence to the instructions that comes with the drug helps the treatment well.

The oral cavity is treated with a cotton swab several times a day. It is advisable to continue treatment until the symptoms disappear completely.

Powder

It is used evenly on the affected areas of the skin several times a day. The success of treatment depends largely on the regularity of the application of the drug. Often, the powder should be used after the visible signs of the disease have disappeared. The duration of therapy is determined by the doctor. Typically, this is from one to four weeks for various diagnoses.

Vaginal pills

The drug is administered in a supine position, inviting the woman to bend her knees. The introduction is carried out at bedtime.

To sanitize the birth canal, one tablet of the drug, 500 milligrams each, is used.

Candide during pregnancy

During pregnancy, Candide is used infrequently and according to strict indications. However, no information has been received about the harm to the mother and her unborn baby during the treatment with Candide. However, only a doctor can authorize the intake of Candida.

Candide for children

For children, Candide is used as a solution. They are treated for stomatitis, strictly adhering to the instructions and recommendations of the doctor. Children are also shown the treatment of fungal infections and thrush in newborns.

Side effects

The use of Candida is fraught with side effects, which should be taken into account when prescribing it:

  • In the places where the cream was applied, tingling, burning sensation, as well as skin rashes accompanied by itching were observed;
  • In addition to skin irritation, swelling or blisters may develop. Typically, the skin becomes rough and irritated.

With such signs of side effects, Candide cream should be canceled immediately.

Also, local irritation can occur when using vaginal tablets. However, the phenomena of this side effect appear infrequently and disappear on their own with further treatment. The negative effects are expressed in the following:

  • in the form of itching accompanied by burning;
  • soreness during intercourse and a burning sensation by a man;
  • vaginal discharge, accompanied by swelling of the vaginal mucosa;
  • urination may increase in frequency with the subsequent development of intercurrent cystitis;
  • headache.

Overdose

An overdose of cream is almost impossible.

In case of accidental use of the drug inside, the patient should rinse the stomach and prescribe enterosorbents. The symptoms of this type of overdose will be the development of nausea, vomiting, allergies. There were cases when drowsiness and the manifestation of hallucinations were recorded.

The development of gastralgia, pollakiuria, anorexia may also result from the use of the drug inside, which is intended for external or vaginal use.

Symptomatic therapy is often required to eliminate unpleasant symptoms.

Drug interactions

A drug containing clotrimazole reduces its effectiveness when combined with Nystatin, Natamycin and Amphotericin B.

In addition to these drugs, there are no other examples of such incompatibility with clotrimazole.

Additional instructions

The product is not applied in the eye area.

It is necessary to monitor the functionality of the liver in those patients who suffer from hepatic ailments.

If hypersensitivity to the drug develops, it should be discontinued immediately.

If after a month's course of treatment, the patient did not receive the expected effect, then the treatment was chosen incorrectly. You should visit a doctor to review the course of treatment.

The medicine does not pose a danger to drivers and other workers in the field of technology.

The product is not suitable for treating skin with a violation of its integrity.

In order to prevent relapses in the treatment of vaginal superinfections, it is necessary to treat both partners.

If the vagina and the labia are affected, it is advisable to carry out treatment, in combination using tablets for introduction into the vagina and a cream for external treatment.

Candide analogues

An action similar to Candida has been observed in a number of drugs. We are talking about medicines: Antifungole, Kandibene, Imidil cream, Clotrimazole, Imidil, Candida B6, Kandizole, Kanestena and Amiclone.

Candid price

According to the latest information from pharmacies, the cost of the drug relative to its dosage forms was distributed as follows:

  • Cream - 251 rubles;
  • solution - 372 rubles;
  • powder - 375 rubles;
  • tablets / suppositories - 82 rubles per piece.

Content

In dermatology, gynecology and other areas, doctors use the drug Candide. It is highly effective, quick to achieve results, and contains clotrimazole. Various forms of drug release are used for external and intravaginal use. Read the instructions for use of Candida and consult your doctor before starting treatment.

Candide drug

Doctors often prescribe the drug Candide - the instructions for its use contain information that the medication belongs to antifungal agents for treating the oral cavity, genitals and skin. The active substance of the composition is clotrimazole, which destroys the cells of bacteria and fungal pathogens, preventing them from multiplying, thereby leading to their death.

Composition and form of release

Five forms of Candida are available, differing in purpose and composition. Detailed composition:

Description

Clotrimazole mg concentration

Package

Colorless transparent viscous liquid

Glycerol, propylene glycol

Dropper bottles 15 ml

Light yellow powder with a characteristic odor

Fragrance, talc, corn starch, colloidal silicon dioxide

Vials of 30 g

Vaginal gel

Uniform white

Water, cetyl alcohol, chlorocresol, cetyl alcohol, sodium hydroxide, propylene glycol, carbopol, glycerol, cetomacrogol emulsion wax, benzyl alcohol

Aluminum tubes 30 g with applicator

White uniform

Water, propylene glycol, sodium hydrogen phosphate, white petrolatum, sodium dihydrogen phosphate dihydrate, liquid paraffin, butyl hydroxytoluene, cetomacrogol emulsion wax, propyl and methyl parahydroxybenzoate, benzyl alcohol

Aluminum tubes 20 g

Vaginal pills

Oval white, truncated, biconvex, no shell

100 or 500 for 1 pc.

Talc, adipic acid, propyl and methyl parahydroxybenzoate, corn starch, povidone, colloidal silicon dioxide, sodium carboxymethyl starch, lactose monohydrate, sodium bicarbonate, magnesium stearate

Packs of 1 or 6 pcs., With applicator

Pharmacodynamics and pharmacokinetics

The entire line of drugs belongs to antifungal agents with a wide spectrum of action for topical use. The active ingredient of the composition is clotrimazole, an imidazole derivative. Its antimycotic effect is associated with a violation of the synthesis of ergosterol, which is part of the cell membrane of the fungus. The component causes a change in the structure of tissues and leads to the lysis (dissolution) of the fungal cell. In low concentrations it acts as a fungistatic, in high concentrations it acts as a fungicide.

In fungicidal concentrations, the drug interacts with mitochondrial enzymes, which work as peroxidase, which increases the concentration of hydrogen peroxide to toxic levels. Yeast-like fungi Candida, dermatophytes, Rhodotorula, Torulopsis glabrata, mold fungi, Pityriasis versicolor (versicolor versicolor) and erythrasma are sensitive to the active substance. The drug destroys gram-positive microorganisms, staphylococci, streptococci, gram-negative Bacteroides, Gardnerella vaginalis, Trichomonas vaginalis.

When applied topically, absorption of clotrimazole is negligible, therefore, the systemic effect is practically not manifested. When applied externally, the concentration of the active substance in the epidermis is higher than in the subcutaneous tissue and dermis. With intravaginal administration of a gel or tablets, absorption of clotrimazole is up to 10% of the dose, the concentration lasts up to 72 hours. In the liver, the substance is metabolized to inactive metabolites.

Indications for use

According to the instructions for use, the indications for use are different factors. The annotation provides:

  • candidal stomatitis of the oral cavity membrane;
  • fungal infections of the skin;
  • erosion between the toes caused by fungi;
  • mycoses with complication of secondary infection;
  • versicolor versicolor;
  • erythrasma;
  • candidal vulvovaginitis, paronychia, balanitis, thrush;
  • trichomoniasis;
  • genital superinfection;
  • dermatophytosis of the scalp, face, body, legs;
  • onychomycosis (nail fungus);
  • candidiasis of the skin, anorectal region, external genitalia;
  • fungal diaper dermatitis;
  • dermatomycosis;
  • rehabilitation before childbirth of the birth canal.

Method of administration and dosage

Each drug in the Candide line has its own instructions for use. So, cream (mistakenly called ointment) and powder are used for external application to the skin. Gel and tablets (vaginal suppositories) are injected intravaginally, drops of solution are used to treat the oral cavity. Depending on the severity of the disease, the course and dosage regimen will differ.

Cream Candide

According to the instructions, Candide cream or ointment is applied to previously washed and dry affected skin areas up to 2-3 times / day. The product is lightly rubbed in and left until absorbed. Treatment of candidiasis continues for 2-4 weeks after the disappearance of the clinical manifestations of the disease in order to ensure mycological cure and prevent recurrence of the infection.

Powder

Powder Candide, according to the instructions, has external use. It is applied to the affected skin 3-4 times / day. According to reviews, improvement occurs in 3-5 days, but systematic use of the drug is required for a successful cure. The average duration of antifungal therapy is a month, with pityriasis versicolor - 1-3 weeks, with erythrasma - 2-4 weeks. If interdigital fungal erosion of the legs is being treated, then the duration of the application of the powder continues for another two weeks from the moment the symptoms subsided.

Gel

For intravaginal use only, Candide gel is intended for the treatment of thrush. According to the instructions, a full applicator with gel (about 5 g) is collected and inserted into the vagina. It is advisable to administer the drug in a supine position with slightly bent knees. The treatment continues every evening for six days. The repetition of the course is determined by the doctor.

Solution

The instruction assumes to use Candide solution for the oral cavity in the amount of 10-20 drops (0.5-1 ml of the drug). The product is applied to the affected skin 3-4 times / day with a cotton swab. On days 3-5, patients notice an improvement in their condition, but treatment should still be continued until the clinical manifestations of the disease are completely eliminated.

Candles

Candide tablets are mistakenly called candles. The drug is used intravaginally, injected as deep as possible in the supine position with slightly bent legs. Each evening you need to use one tablet for six days. For the rehabilitation of the birth canal before childbirth, one piece is prescribed. To facilitate the administration of the drug, an applicator is used. Instructions for its use (also suitable for using the gel):

  • push the piston all the way out;
  • place a tablet inside;
  • gently insert the applicator deep into the vagina;
  • slowly press the piston all the way down;
  • remove the applicator;
  • Pull the plunger out completely, wash with warm water and soap and wipe dry.

special instructions

If Candide is used, the instructions for use assume the study of special instructions. Part of the excerpts suggests that:

  • the solution is used only as a treatment for the oral cavity;
  • intravaginal forms cannot be used during menstruation;
  • in order to prevent reinfection, it is also advisable for the sexual partner to undergo a course of treatment;
  • drugs are not used in ophthalmology;
  • in trichomoniasis, for successful treatment, therapy is combined with taking systemic drugs, for example, Metronidazole;
  • with the simultaneous manifestation of candidiasis on the vulva of the labia and adjacent areas, it is allowed to combine intravaginal forms of the drug with a cream;
  • during pregnancy, the applicator cannot be used to inject gel and tablets;
  • when treating patients with hepatic insufficiency with Candida, the functional parameters of the liver should be monitored;
  • if signs of hypersensitivity or local irritation appear on the skin and genitals, therapy is canceled;
  • if there is no effect from drugs within a month, the diagnosis should be reconsidered;
  • medications do not affect the concentration of attention and the speed of psychomotor reactions, so they can be used when driving vehicles and dangerous mechanisms.

During pregnancy

During pregnancy and breastfeeding, the instruction allows the use of the medication only if the benefit to the mother exceeds the risk to the fetus or newborn. Intravaginal forms of drugs are contraindicated in the first trimester of pregnancy. According to experiments, high doses of clotrimazole cause embryotoxic effects. It is not known whether the active substance is excreted in breast milk.

Candide for children

Children have no experience with the use of drugs in the line, therefore, before prescribing, it is worth considering the possible risk to the body. It is known that long-term use of clotrimazole in a child leads to an increased risk of adrenal suppression. Be sure to obtain permission from your doctor before using any dosage forms of the drug and do not try to prescribe them yourself.

Drug interactions

According to these instructions, the simultaneous use of clotrimazole with amphotericin B, nystatin reduces the effect of the drug. Doctors allow to combine drugs with systemic antibiotics and antimicrobial agents, plus with forms for external and intravaginal use. Before using any combination of drugs, you should consult your doctor.

Side effects

According to patient reviews, the drugs are well tolerated. Possible side reactions when using them are:

  • allergic reactions, redness of the vaginal mucous membranes;
  • burning, tingling at the site of application;
  • urticaria, erythema;
  • itching, blistering;
  • swelling, irritation of the vaginal mucosa, peeling;
  • when such symptoms appear, Candide therapy is canceled.

Overdose

When applied topically, an overdose of Candide is unlikely and does not lead to situations that threaten human life and health. With prolonged use of the cream in children or with an occlusive dressing in adults, the risk of suppression of the function of the adrenal cortex increases, therefore, during treatment, the vital signs of the work of these organs should be monitored.

Contraindications

Instructions for use Candide advises to use drugs with caution during pregnancy, lactation, in childhood. Contraindications for intravaginal forms of drugs are the first trimester of pregnancy and using an applicator, for all others - hypersensitivity to the components of the composition and other imidazole derivatives.

Terms of sale and storage

You can buy Candide without a prescription, it is stored away from light and children at a temperature not exceeding 25 degrees. The shelf life is three years from the date of issue.

Analogs

There are many analogues of Candida for the active ingredient clotrimazole. There are also indirect substitutes for the drug that act similarly in terms of therapeutic effect. The analogs of the drug include medicines with clotrimazole in the composition:

  • Clotrimazole;
  • Kanizon;
  • Kandibene;
  • Travocort;
  • Biphon;
  • Bifunal;
  • Kanespor;
  • Mycospore;
  • Dermazole;
  • Ketozoral.

Candida price

You can buy drugs in the line through the Internet or pharmacy chains. Prices for funds depend on the form of release and the concentration of clotrimazole. The approximate cost will be.

Candide is the trade name of clotrimazole, a popular remedy for infections of the skin and oral mucosa, as well as urogenital diseases of fungal pathogenesis. The manufacturer of the drug is the Indian pharmaceutical company Glenmark Pharmaceuticals. The instructions for use for Candide describe it as an antimycotic agent that helps against most dermatophytes, yeasts and molds, as well as some microbes and bacteria, including streptococci, staphylococci and other gram-positive pathogenic microorganisms.

Clotrimazole is an active substance in the composition of a drug (MP), it is a drug based on imidazole. Indications for use for Candide are identical to clotrimazole:

  • candidal stomatitis - a fungal disease of the oral mucosa;
  • urogenital trichomoniasis - a fungal infection caused by the bacterium Trichomonas;
  • pityriasis and / or colored lichen - a fungal infection of the skin on the trunk and chest;
  • foot fungus (the so-called athlete's foot);
  • fungal disease of the nails of the hands and feet;
  • vaginal candidiasis (thrush);
  • vaginitis, vulvitis (infection of the external female genital organs);
  • fungal balanitis (a disease of the skin of the head of the penis and foreskin);
  • superficial mycoses of the skin;
  • sanitation of female genital organs before childbirth.

Clotrimazole exhibits fungicidal activity - it inhibits the growth and reproduction of fungi, acting on the cell membrane of microorganisms. When used externally, it is poorly absorbed into the skin and mucous membranes.

Most of the substance accumulates in the stratum corneum of the epidermis.

Candide, depending on the form of the drug, is used for external or local application / administration - applied to the skin or mucous membranes, and also inserted into the vagina for the treatment of fungal diseases. Upon contact with the mucous membrane of the mouth, vagina and the head of the penis, up to 10% of the active substance is absorbed.

Forms of issue

Candide comes in various forms for topical and topical use:

  • cream;
  • gel;
  • vaginal tablets;
  • solution;
  • powder.

All forms of the drug contain 10 mg of clotrimazole per 1 g of substance.

Instructions for use

Based on the form of the drug, it is applied to various parts of the body (skin around nails, feet, skin folds, penis) or inserted into the vagina using an applicator or in the form of tablets.

For the oral cavity

For candidal stomatitis, a solution is used as a local drug, which is applied to the affected areas of the oral mucosa with a cotton swab 3-4 times a day. The course of therapy is up to 5 days or until the symptoms of fungal infection of the mucous membrane completely disappear.

For exposed skin areas

For the treatment of foot and nail fungus, skin mycoses, pityriasis or pityriasis, manifested in the form of rashes, age spots, redness and itching in the folds of the skin, a gel / cream is taken. A small amount of the substance should be applied to the skin or mucous membranes 1-2 times a day after skin hygiene. The course of therapy is up to 3-4 weeks, plus another 14 days to consolidate the result.

For the genitals

Candide can be used by both men and women to treat mycoses of the vulva, vagina, urethra and glans penis and foreskin. For infections of the vulva (external genitalia of women) and the head of the penis, a powder or gel is used, which is applied 2-3 times a day for 1-2 weeks.

For vaginal candidiasis (thrush), pills are used that are inserted into the vagina. The treatment regimen, according to the annotation, is 500 mg once, 200 mg every day for 3 days or 100 mg for 7 days. The gel is injected deep into the vagina in a supine position using a vaginal applicator, which is in the package with the drug. The drug is best administered intravaginally before bedtime after genital hygiene.

For urethral infections, a solution is used which is injected into the urethra with a special applicator. The drug must be used daily for 6 days.

It is necessary to store the medicine in its original packaging, closed in a dry place protected from direct sunlight at a temperature not exceeding 25 degrees.

Contraindications

The drug is not recommended for hypersensitivity to the active substance. During pregnancy, it is allowed to apply Candide to treat infection only on open skin areas - feet or hands. The medicine in the form of tablets or gel is not recommended for use in the 1st trimester, since there is no data on the effect of the active substance on the developing fetus. In the 2-3 trimester, intravaginal use in the form of tablets is conditionally allowed with the recommendation of a doctor. It is undesirable to use a special applicator with a plunger for insertion.

If there is a need to use a clotrimazole-based drug for the treatment of thrush or stomatitis during breastfeeding, it is recommended that you first consult with your doctor.

The drug is not used during menstruation. When using a cream, gel or powder for the treatment of candidal balanitis or vulvitis, it is recommended to refrain from intercourse. There is evidence that clotrimazole ointments and gels affect latex and may reduce the effectiveness of barrier contraceptives.

When treating genital infections in men and women, a course of treatment with the drug of both partners is recommended to avoid re-infection.

Dosage

For topical application in open areas of the body, as well as for administration into the vagina and local use in the oral cavity, the maximum single dose is 0.5-1 ml for solution or 500-1000 mg for tablets. The agent is well tolerated by the body, side allergic reactions are rare.

Side effects

Side effects noted by the manufacturer with external or local use of Candida include:

  • with external use - a burning sensation, itching, redness, swelling or peeling of the skin;
  • in the treatment of urogenital fungal pathologies - itching, burning, swelling of the mucous membrane of the external genitals, discharge from the genital tract, increased urge to urinate, pain during intercourse;
  • for the treatment of candidal stomatitis - redness, itching or irritation of the oral mucosa in the area of ​​application.

If the described side effects appear, it is recommended to stop using Candide and other clotrimazole-based drugs. Dermatologists advise choosing a drug based on another antimycotic component.

Price

The cost of Candida, depending on the form of release, varies in the following values:

  • vaginal tablets - 65-80 rubles;
  • solution for external use - 330-370 rubles;
  • liquid for topical use - 260-300 rubles;
  • powder - 295-335 rubles;
  • cream for external use - 230-285 rubles;
  • vaginal gel - 100-120 rubles.

Analogs

Candida has several analogues - drugs for external and local use based on clotrimazole:

  • Candide-B6 (tablets).
  • Clotrimazole (cream and ointment, tablets).
  • Kanizon (cream, gel, tablets for vaginal administration, powder for external use).
  • Candizol (tablets for insertion into the vagina, cream for external use).

Clotrimazole is also a part of drugs such as Kanesten, Imidil, Amiklon, Factodin, Kandibene.

The drugs described above are synonyms or complete structural analogs, since have the same active ingredient. Cheap analogues of Candida, which have a similar pharmacological effect, include drugs based on other antifungal drugs:

  • ketoconazole (trade names Livarol, Dermazole, Mycozoral);
  • miconazole (in the preparations Ginesol 7, Mikozon);
  • naftifine (Exoderil, Mizol Evalar);
  • terbinafine (Lamisil, Lamican, Fungoterbin);
  • fluconazole (Diflucan, Flocoside, Flucostat).

These and other antifungal drugs are recommended for the treatment of skin fungal diseases of the nails, feet, urogenital fungal infections, stomatitis and other focal lesions of the skin and mucous membranes. The drugs can be found in the form of topical and topical agents (gels, creams, powders, solutions, sprays, shampoos).

Overdose

There is no evidence of an overdose of clotrimazole with external or local use. If accidentally ingested, symptoms such as nausea, vomiting, heartburn, loss of appetite, stomach pain, and liver dysfunction are possible. Treatment is symptomatic (taking sorbents, antacids, antiemetic drugs).

3D images

Compound

Description of the dosage form

Colorless, transparent, viscous liquid.

pharmachologic effect

pharmachologic effect- broad spectrum antifungal.

Pharmacodynamics

Clotrimazole is an imidazole derivative, a broad-spectrum antifungal agent.

The antimycotic effect is associated with a violation of the synthesis of ergosterol, which is part of the cell membrane of fungi, which causes a change in its structure and properties and leads to cell lysis.

Dermatophytes, yeast-like fungi (genus Candida, Torulopsis glabrata, Rhodotorula), mold fungi, as well as the causative agent of varicoloured lichen Pityriasis versicolor and the causative agent of erythrasma.

Has antimicrobial effect against gram-positive (staphylococci and streptococci) and gram-negative bacteria ( Bacteroides, Gardnerella vaginalis) as well as regarding Trichomonas vaginalis.

Pharmacokinetics

When applied topically, the adsorption of clotrimazole from the mucous membranes is negligible.

Indications of the drug Candide

Candidal stomatitis.

Contraindications

Hypersensitivity to the components of the drug.

Application during pregnancy and lactation

The use of the drug during pregnancy or lactation is allowed in cases where the intended benefit to the mother outweighs the risk to the fetus or infant.

Side effects

The drug is usually well tolerated. In rare cases, with hypersensitivity to the components of the drug, allergic reactions are noted - redness of the oral mucosa, a burning sensation and tingling sensation at the site of application of the drug, urticaria.

If irritation occurs, the drug must be canceled.

Interaction

With simultaneous use with amphotericin B, nystatin, the activity of clotrimazole may decrease.

Method of administration and dosage

Locally, 10-20 drops (1 / 2-1 ml) are applied to the affected areas of the oral cavity using a cotton swab 3-4 times a day. Improvement of the condition usually occurs on the 3-5th day of treatment, however, treatment must be continued until the clinical manifestations of the disease are completely eliminated.

Overdose

Cream Candide contains an active ingredient clotrimazole , as well as auxiliary components: white petrolatum, propylene glycol, emulsion cetomacrogol wax, liquid paraffin, butyl hydroxytoluene, propyl parahydroxybenzoate, methyl parahydroxybenzoate, benzyl alcohol, sodium hydrogen phosphate, sodium dihydrogen phosphate dihydrate, purified water.

Solution Candide contains an active ingredient clotrimazole as well as glycerol and propylene glycol as additional components.

Vaginal tablets contain in the composition clotrimazole as an active ingredient, as well as additional ingredients: purified talc, starch, magnesium stearate, lactose, silicon dioxide, propylparaben, methyl parahydroxybenzoate, sodium carboxymethyl starch.

Release form

The medicine has several forms of release. Currently, Candide gel 2%, cream for external use 1%, powder for external use 1%, solution for topical use 1%, as well as vaginal tablets (suppositories) Candide are produced.

  • The cream is a homogeneous white substance contained in a 20 g aluminum tube.
  • Solution for topical application, transparent, colorless, has a viscous consistency. The bottle contains 15 g of the product.
  • Powder for external use (dusting) is contained in a plastic bottle of 30 g.

pharmachologic effect

The drug produces a local antibacterial and antifungal effect, also has an antiprotozoal and trichomonacid effect. There is a wide range of antifungal effects.

Antimycotic effect clotrimazole (the active component of the drug is an imidazole derivative) occurs due to a disruption in the synthesis of ergosterol, which is part of the fungal cell membrane. As a result, membrane permeability changes and subsequent cell lysis occurs.

The interaction of fungicidal concentrations with mitochondrial and peroxidase enzymes is noted, and as a result, the concentration of hydrogen peroxide increases to the level of toxicity. As a result, fungal cells are destroyed.

Fungistatic and fungicidal activity against dermatomycetes ( Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), mold and yeast-like fungi (mushrooms Candida spp., Torulopsis glabrata, Pityrosporum orbiculare, kind Rhodotorula).

Also, clotrimazole demonstrates activity against the causative agent of varicolored lichen.

The agent is effective against gram-positive bacteria and a number of gram-negative bacteria. Subject to the use of high concentrations, the agent is active against Trichomonas vaginalis.

Pharmacokinetics and pharmacodynamics

Clotrimazole is poorly absorbed through the skin and mucous membranes, therefore, when the drug is used externally, systemic action is not observed. When applied externally, a higher concentration of clotrimazole is observed than in the subcutaneous tissue and in the dermis.

When administered intravaginally, the absorption of clotrimazole is equal to 3% to 10% of the dose that is administered. Within 2 to 3 days, there are small concentrations of the active substance in and a high level of concentration in vaginal secretions.

Side effects

The manifestation of the following side effects may develop when using this agent:

  • , burning and tingling sensation where the cream was applied;
  • , blisters , peeling and irritation of the skin.

If such manifestations are noted, it is necessary to cancel the Candide ointment and.

When using Candida intravaginally, the development of local irritation is rarely noted, which, as a rule, disappears on its own with further treatment. Also, with intravaginal use of the drug, the development of such negative effects is possible:

  • itching, burning;
  • vaginal discharge and swelling of its mucous membranes;
  • frequent urination and intercurrent ;
  • burning sensation in the genitals of a man.

Application instruction of Candida (Way and dosage)

Cream Candide, instructions for use

Ointment is applied externally. Before applying the product, you must first clean and dry those areas of the skin that have been affected. For cleaning, use soap with a neutral pH value. The cream is applied in a thin layer and rubbed gently into the skin, doing this two to three times a day. The treatment lasts as long as the doctor prescribes. Its duration depends on the localization and severity of the disease, as well as on the effectiveness of treatment.

In the treatment of dermatomycosis, the course of application is at least 4 weeks, in the treatment of pityriasis versicolor, the cream should be applied from 1 to 3 weeks. For people who suffer from fungal diseases of the skin of the legs, the cream should be applied regularly for at least two weeks after the symptoms of the disease have disappeared.

How to use the gel also depends on the severity and characteristics of the course of the disease. As a rule, the agent is rubbed into the affected area 2-3 times a day. It is advisable to use the gel for another 3-4 weeks in order to completely eliminate possible relapses.

Solution Candide, instructions for use

The agent in the form of a solution is prescribed for large lesions of the skin, as well as for lesions of the scalp. If Candide drops are prescribed to the patient, the instructions for use must be carefully followed. In case of damage to the oral cavity using a cotton swab, the solution is applied in 10-20 drops, doing this 3-4 times a day. It is important to treat all affected areas very carefully. You need to use the tool until the clinical symptoms disappear.

Powder instruction

Powder Candide is applied externally, it must be applied to the affected skin 3-4 times a day. It is important to apply the product regularly. The duration of therapy depends on the severity of the disease, as well as on the localization of the disease. In order to completely cure the disease, sometimes treatment is continued even after the expressed symptoms disappear. The duration of treatment is usually 4 weeks. Patients with pityriasis versicolor are recommended to use the drug for 1-3 weeks, patients suffering from erythrasma , it is shown to carry out treatment for 2-4 weeks.

The agent in the form of vaginal tablets is injected intravaginally, this should be done in the supine position, with the legs bent. It is necessary to use the tablets once a day, before bedtime. In order to sanitize the birth canal, one tablet (500 mg of the drug) is administered.

Overdose

When using the cream in high doses, there are no manifestations of reactions, as well as life-threatening conditions.

If the drug was taken orally, the patient may develop nausea, vomiting, gastralgia, anorexia, pollakiuria, and allergic manifestations. Development is rarely noted ,. There is no specific, when taken orally, Candide drugs are prescribed, and symptomatic therapy is also practiced.

Interaction

The effect of clotrimazole is reduced with the simultaneous use of funds Nystatin, , Natamycin , which is why Candide ointment and other forms of the drug should not be used in the treatment of the listed drugs.

In general, when using the cream at the same time with other drugs, the negative effects of other drugs are not known, since there is a low resorption capacity of clotrimazole.

Terms of sale

Available without a doctor's prescription.

Storage conditions

It is necessary to protect all forms of Candida from children, store at a temperature of 2 to 25 ° C.

Best before date

You can store Candide ointment for 4 years, Candide solution can be stored for 3 years.

special instructions

Do not apply the product to the skin in the eye area.

When using the drug, you should periodically monitor the state of the liver of a patient who suffers from liver failure.

If signs of high sensitivity appear during use, treatment with the drug should be discontinued.

If, when using the drug for 4 weeks, there is no effect of treatment, it is necessary to confirm the diagnosis by visiting a specialist.

The use of the product does not affect the ability to drive vehicles and work with precise mechanisms.

Do not apply the product for external use on those areas of the skin on which there are violations of integrity.

To prevent the development of urogenital reinfection, it is important to carry out simultaneous treatment of both sexual partners.

If the vagina and labia are affected, Candide cream and vaginal tablets should be used simultaneously.

Analogs

Matching ATX level 4 code:

A number of drugs with a similar effect are produced. These are medications , Imidil cream , Imidil , Kanesten , Candide-B6 , , etc. The price of analogs depends on the manufacturer, form of release, packaging of the drug.

Cream Candide and Candide B have a similar effect, but Candide B, in addition to clotrimazole, also contains beclomethasone as an active ingredient.

For kids

Remedy Candide in the form of a solution is used for stomatitis in children, it must be used according to the instructions and on the recommendation of a doctor. The tool is also used in the treatment of a number of fungal diseases, in particular, it is used to treat babies from ... Candide from thrush in newborns and children is used strictly as directed by a doctor.

Candide for newborns

Solution Candide for newborns is used to treat candidiasis in infants. It is necessary to carry out procedures for thrush in infants after feeding. To carry out such a procedure, a few drops of the solution (3-4 drops) are applied to a cotton swab or tampon, after which they gently lubricate those areas in the oral cavity that have been affected. This procedure should be carried out three times a day. Already after 2-3 days, there should be clear signs of improvement.

During pregnancy and lactation

There is no clinically established data that the use of Candide medication locally during pregnancy, as well as during breastfeeding, adversely affects the health of a woman or an unborn child. But it is important that the decision on the use of the drug during the second and third trimester of pregnancy, as well as during lactation, is made by the doctor.

Do not apply the product to the mammary glands during lactation.

Reviews about Candida

On the network, there are mainly positive reviews about Candide cream. Users note that the ointment allows you to very effectively overcome the problems associated with the development of fungal diseases. Solution Candide is often used by parents to treat children, noting that the drops are convenient to use and at the same time, the negative manifestations of diseases are reduced almost from the first applications. Adult patients also write that with the help of a cream or gel, they managed to completely cure fungal diseases and get rid of unpleasant manifestations. Thus, Candide cream works no less effectively than any other suppositories or other forms of medicine.

Candida price where to buy

The price of Candide 1% cream is from 250 rubles per pack of 20 g. The ointment may cost more, depending on the place of sale. The price of the Candide solution is on average 370 rubles. per package 20 ml. How much this form of the drug costs depends on the packaging. Drops for children in a 15 ml package can be purchased at a price of 270 rubles.

Powder for external use costs an average of 340-380 rubles per package of 30 g. Powder for newborns is sold without a prescription in any pharmacy. Gel Candide costs an average of 120 rubles. per unit 30 g. The price of Candida in suppositories (the cost of vaginal tablets) is from 80 rubles. for 1 pc.

  • Online pharmacies in Russia Russia
  • Online pharmacies of Ukraine Ukraine
  • Internet pharmacies in Kazakhstan Kazakhstan

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