Antifungal antibiotic
Active substance
Release form, composition and packaging
Film-coated tablets light yellow in color, with a greenish tint, with a slight vanillin scent; the cross section shows two layers.
Excipients: anhydrous lanolin, medical.
30 g - aluminum tubes.
Vaginal suppositories yellow, torpedo-shaped.
Excipients: paraoxybenzoic acid propyl ester, edible citric acid, vaseline oil, witepsol N-15, witepsol W-35.
5 pieces. - contour cell packaging (2) - cardboard packs.
pharmachologic effect
Antifungal drug from the polyene group. By binding to sterols in the cell membrane of fungi, it disrupts its permeability, which leads to the release of the main components of the cell. Has fungistatic effect.
Active against yeast-like fungi of the genus Candida.
Pharmacokinetics
Absorption and distribution
After oral administration, nystatin is poorly absorbed from the gastrointestinal tract. When applied topically, it is not absorbed into the systemic circulation. Does not cumulate.
Withdrawal
It is excreted from the body with feces.
Indications
For tablets and ointments
- candidiasis of the skin and mucous membranes;
- candidiasis of internal organs;
—Prevention of candidiasis with prolonged drug therapy, especially in emaciated and debilitated patients.
For vaginal suppositories
- vaginal candidiasis;
- Prevention of fungal complications with local antimicrobial therapy.
For rectal suppositories
- Hypersensitivity to the components of the drug.
Dosage
At treatment of candidiasis of internal organs Nystatin is administered orally, regardless of food intake.
Adults appoint 500,000 IU 4-8 times / day.
At generalized candidiasis appoint up to 6,000,000 U / day.
Children aged 1-3 appoint 250,000 IU 3-4 times / day, over the age of 3- 250,000-500,000 units 4 times / day. The duration of treatment is 10-14 days. If necessary, repeat the course of treatment in a week.
At treatment of candidiasis of the skin and mucous membranes the ointment is applied in a thin layer to the affected areas 2 times / day, daily for 7-10 days. The use of the ointment can be combined with the intake of Nystatin inside.
Vaginal suppositories are inserted into the vagina after hygiene procedures, 1 suppository 2 times / day (morning and evening). The course of treatment is 10-14 days.
Rectal suppositories are injected deep into the rectum, 1 suppository 2 times / day (morning and evening). The course of treatment is 10-14 days.
If necessary, repeated courses of treatment are carried out.
Side effects
From the digestive system: when taking the drug inside and using rectal suppositories, nausea, vomiting, diarrhea are possible.
Allergic reactions: itching, chills, fever.
Others: the risk of spreading resistant forms of fungi is possible, which requires discontinuation of the drug.
Overdose
Currently, no cases of overdose of the drug Nystatin have been reported.
For the treatment of fungal diseases of the genital area in women, systemic and local preparations are used. The purpose of their work is to destroy the pathogen in the body and directly affect the affected area. Due to the fact that the drug Nystatin has not loud reviews, suppositories from thrush of this name are not prescribed so often. The hearing of more expensive and more publicized drugs prompts consumers to give them preference.
Medical practice, despite all the circumstances, shows that Nystatin is an affordable and effective drug in the fight against vaginal candidiasis.
Description of the medicinal product
The drug Nystatin is a yellowish-white vaginal suppository made of solid fatty mass. The medicine is produced in a cardboard package, on which the trade name, dosage and additional information about the manufacturer are indicated in green letters. Despite the fact that Nystatin candles are a single tool, they can be produced by various manufacturers, among which the most popular are Nizhpharm, Biosynthesis and Biochemist. The drug is also produced abroad, for example, by the Belarusian pharmaceutical company Borisov Medicines Plant.
The suppository package contains two adhesions, 5 candles each. The cost of domestic Nystatin is quite democratic and is no more than 100 rubles. Some women refuse to purchase an inexpensive medicine for thrush, considering it ineffective. However, even for such a small amount, you can get a sufficient healing effect.
The main active component of the vaginal remedy is the substance of the same name - nystatin. Each suppository contains 250 or 500 units of antifungal medication. As additional substances used: butyloxyanisole, antioxidant, dibunol, citric acid, vaseline base and witepsol. Auxiliary components do not have an antifungal effect on the patient's body and are included in the composition to obtain the appropriate form of medication.
How does Nystatin work?
The eponymous component of Nystatin binds to sterol molecules found in the cell membrane of the microorganism. The result is a channel for transporting electrolytes. The culmination of the increase in the concentration of the substance in the cell of the fungus is death. Conditionally pathogenic structure dissolves in the absence of resistance to the active substance of the drug.
The active substance of vaginal suppositories is not absorbed through the mucous membranes and does not accumulate in the tissues. For this reason, Nystatin suppositories can be called a safe remedy with a minimum number of contraindications.
Other forms of release
Antifungal manufacturers offer alternative forms: topical cream and oral tablets. The use of an ointment substance is recommended for women with candidal vaginitis and for men for the treatment of balanitis and balanoposthitis. Also, the cream can be used against fungal infections of the skin.
Nystatin tablets for thrush are prescribed when the pathogens of Candida spread through the gastrointestinal tract, and reviews of this use of the drug are positive. Patients are satisfied with the treatment result and the availability of the chosen medication. An oral agent is often used for prophylactic purposes, for example, with the course of antibiotics.
Vaginal suppositories are effective against Candida and Aspergillus pathogens, as well as some other yeast-like fungi.
Contraindications for use
Among all antifungal drugs, Nystatin tablets (vaginal and oral) are considered the most proven and safest drugs. They have a minimal number of contraindications, in comparison with alternative drugs based on substances acting by analogy.
Vaginal suppositories are prohibited for women under 18 years of age. Oral medication should not be used for pancreatitis, ulcers, and liver problems. The cream is contraindicated for children under the age of one year. All types of antifungal drugs are prohibited for use with hypersensitivity to the active substance and during pregnancy.
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To be sure that there are no contraindications and not to rely on a lucky break, you should consult a specialist before using the medication. Perhaps the doctor will prescribe additional remedies for thrush so that the treatment is as effective as possible. At the same time, one should not forget about the possibility of combining Nystatin with other pharmaceutical products.
Interaction
The simultaneous use of Hydrocortisone, a steroid hormone of the adrenal cortex, reduces the effectiveness of the use of Nystatin in any form.
Doctors often prescribe a comprehensive treatment for thrush. The simultaneous use of Clotrimazole or drugs based on it is impractical, since the effectiveness of the use of antifungal agents individually is much higher than their combination.
The composition of vaginal suppositories is chemically incompatible with folk remedies for thrush:
- Hydrogen peroxide (water and oxygen based antiseptic);
- Potassium permanganate (oxidative antiseptic);
- Salicylic acid (anti-inflammatory);
- Lactic acid (breakdown product of glucose);
- Sodium bicarbonate (alkaline antiseptic).
The instruction for the use of Nystatin for thrush does not contain information on the possibility of the simultaneous use of alcoholic beverages. It should be understood that alcohol causes an exacerbation of vaginal candidiasis, distorting carbohydrate metabolism, and increases the likelihood of adverse reactions to treatment. When evaluating the interaction, one should refrain from the simultaneous use of Nystatin in any form and alcohol-containing drinks.
Method of using suppositories for thrush in women
Nystatin in the form of suppositories is used twice a day: in the morning and in the evening. Before the introduction of the drug, hygiene procedures should be performed. It is permissible to insert the suppository only with clean hands with a short-cropped manicure, otherwise there is a high probability of secondary infection. After using the candles, it is necessary to be in a horizontal position for half an hour so that the active substance is evenly distributed over the mucous membranes. It is better to postpone the evening use of Nystatin for the time before bedtime.
If stomach candidiasis is found (with intestinal candidiasis), then rectal administration of suppositories is carried out twice a day for 10 days. At the same time, oral administration of an antifungal drug is prescribed in a dose of 500 to 6000 thousand IU 4-8 times a day. The use of the medicine is not attached to food intake, which is very convenient for patients. The average duration of pill treatment is 2 weeks.
Features of use
For women with vaginal administration of the drug, it is recommended to exclude sexual intercourse during treatment, including with a condom. If a partner has complaints, it is necessary to be examined and undergo individual treatment. Conducting therapy in a couple increases the effectiveness of treatment in comparison with the unilateral use of Nystatin.
Vaginal suppositories should not be used during menstruation. Doctors recommend calculating the cycle in advance so that the treatment falls for a time after the end of the bleeding. During treatment, irrigation of the vagina, douching, the use of tampons and unconventional methods of influencing the fungus are prohibited.
Women who used the medication say that during treatment, daily sanitary napkins should be used to prevent damage to the linen of the oily base preparation.
Thrush therapy requires dieting. During the treatment period, it is necessary to refuse carbohydrate products: sweets, pastries, beer. The consumption of dairy products should be kept to a minimum. The diet should contain proteins, fiber, coarse fiber, fermented milk products, which are a source of beneficial bacteria. Drinking plenty of fluids speeds up the healing process.
Negative effects of therapy
Similar to any drug, antifungal nystatin therapy in women can form negative reviews. This usually happens when side reactions appear.
The use of suppositories is characterized by the appearance of burning and itching in the vagina. Unpleasant manifestations disappear spontaneously after a few days, but on the first day of use they cause serious discomfort to the patient.
Oral intake of Nystatin can cause dyspeptic disorders in the form of nausea, diarrhea, vomiting and other disorders. Patients often complain of loss of appetite, heartburn. With sluggish and unknown to the woman gastrointestinal diseases, an exacerbation may occur. It manifests itself as heartburn, abdominal pain, flatulence, and sour belching.
Nystatin is an antibiotic of the polyene group that is active against pathogenic fungi.
It is used for the treatment and prevention of diseases caused by microorganisms against which the drug is effective. It is produced in the form of tablets for oral administration, as well as in the form of suppositories for vaginal and rectal administration. Usually well tolerated by the body, except in cases of drug intolerance.
Therefore, in order to cure thrush, you need not only competent treatment, but also effective medications. Antifungal antibiotics are needed to treat these conditions. One of these drugs is Nystatin.
Composition
The candles have the following composition:
- active ingredients: nystatinum; 19-mycosaminylnistatinolide;
- 1 suppository contains 250,000 units of nystatin (based on the activity of 4400 units / mg and dry matter) - 0.0555 g or 500,000 units (based on the activity of 4400 units / mg and dry matter) - 0.111 g
Excipients: butyloxyanisole, butyloxytoluene, citric acid monohydrate, mineral oil, solid fat.
Pharmacological properties
Nystatin is a topical antifungal drug. This drug is a group of polyenes. In the case when nystatin enters the mucous membrane, a process is started that allows the active active substance of the nystatin drug to be slowly released.
The drug begins to penetrate the cell membranes of the pathogens inside, which caused the infection. Subsequently, the drug violates permeability. This process leads to the cessation of further development and reproduction of the infection, as well as, subsequently, to its complete destruction.
The drug is quite highly effective in comparison with other drugs and is very resistant against yeast-like fungi.
When do Nistanin candles help?
Suppositories Nystatin are prescribed to patients for vaginal and rectal use. The main indications for the use of this drug are:
- Vaginal candidiasis caused by yeast-like fungi of the genus Candida ().
- Lesion of the mucous membranes of the lower parts of the large intestine.
- Prevention of fungal infections of the intestine after undergoing operations in the lower parts of the large intestine.
- In order to prevent the development of fungal diseases against the background of long-term treatment with antibiotics or local antibacterial agents.
Contraindications
Suppositories Nystatin are sold in a pharmacy without a doctor's prescription, however, before using candles on your own, you should familiarize yourself with a number of contraindications. Nystatin is a harmless substance that rarely provokes adverse reactions.
Among the possible prohibitions on therapy, it should be noted:
- severe liver damage;
- during pregnancy and lactation;
- menstruation;
- lack of perception of nystatin in the patient;
- bloody discharge from the genital tract, the cause of which has not been established;
- hemorrhoidal nodules in the anus;
- malignant neoplasms in the rectum.
Candles Nystatin, instructions for use
According to the instructions, Nystatin vaginal suppositories are inserted deep into the vagina. The dosage regimen is individual. Usually 1 candle in the morning and in the evening. The duration of treatment is 14 days. During menstruation, treatment is not interrupted. Avoid sexual intercourse during treatment.
Treatment of the sexual partner is necessary. During pregnancy, suppositories with Nystatin are used as prescribed by a doctor in urgent need.
How to take Nystatin suppositories for thrush?
C is injected deep into the vagina 2 times a day. It is very important that the sexual partner also treats with antifungal tablets. If they do not receive treatment, there is a chance of re-infection of the woman. In case of a mild course of the disease, topical preparations can be replaced with a single dose of Fluconazole.
With recurrent candidiasis, which tends to exacerbate more than 4 times a year, a combination of local and systemic administration of drugs with one active ingredient is necessary. So, topically applied ointment and tablets for thrush inside. The following treatment scheme is also possible: a suppository with Nystatin 250,000-500,000 IU per night for 14 days, a thin layer of ointment on the mucous membrane of the vulva and vagina 2 times a day for 14-21 days and tablets of 500,000 IU 4 times a day for up to 10 days.
If there is a combined infection (yeast-like fungi and various bacteria), then complex preparations are used, which include nystatin: Macmiror, Terzhinan, Mikozhinaks, Polygynax.
Nystatin during pregnancy
Pregnancy is a predisposing factor for the development of vulvovaginitis. The main thing in this situation is the safety of the treatment. The instruction includes contraindications for the use of nystatin during pregnancy, since there is no information about their safety for the fetus. Suppositories Nystatin during pregnancy can be used only in exceptional cases, when the benefit to the mother outweighs the risk to the fetus. Feedback from forum visitors confirms that the drug in this form is sometimes prescribed to pregnant women for short courses of treatment.
The use of ointment is contraindicated during pregnancy. However, it has been proven that the active substance is not excreted in milk when applied externally, so breastfeeding can be continued during treatment with ointment. At the same time, you cannot apply the ointment to the breast and nipple area.
Side effects
Nystatin is well tolerated by the human body, so suppositories based on it rarely cause undesirable effects. Side effects can be observed only with intolerance to the components of the drug. Possible reactions include:
- nausea;
- diarrhea;
- rise in body temperature;
- chills.
If these symptoms appear, you should consult a doctor to correct the therapy regimen.
special instructions
You should not interrupt treatment with vaginal suppositories during menstruation. In case of fungal diseases of the vagina, it is recommended to carry out simultaneous treatment of the sexual partner. During the period of therapy, it is necessary to avoid sexual intercourse.
Drug interactions
With the simultaneous administration of Tetracycline and Nystatin, the therapeutic effect of both drugs is enhanced. It is not recommended to take pills together with antacids, because this reduces their medicinal properties. The effectiveness of oral contraceptives and indirect anticoagulants under the influence of Nystatin is greatly reduced. The medicine negatively affects other antibiotics, reducing their effect on pathogens.
vaginal suppositories
Owner / Registrar
BIOSINTEZ, JSC
International Classification of Diseases (ICD-10)
B37.2 Candidiasis of the skin and nails B37.3 Candidiasis of the vulva and vagina (N77.1 *) B37.8 Candidiasis of other sites Z29.8 Other specified preventive measuresPharmacological group
Topical antifungal agent
pharmachologic effect
Antifungal drug from the polyene group. By binding to sterols in the cell membrane of fungi, it disrupts its permeability, which leads to the release of the main components of the cell. Has fungistatic effect.
Active against yeast-like fungi of the genus Sandida.
Pharmacokinetics
Absorption and distribution
After oral administration, nystatin is poorly absorbed from the gastrointestinal tract. When applied topically, it is not absorbed into the systemic circulation. Does not cumulate.
Withdrawal
It is excreted from the body with feces.
For tablets and ointments
Candidiasis of the skin and mucous membranes;
Internal candidiasis;
Prevention of candidiasis with long-term therapy with antimicrobial drugs, especially in malnourished and debilitated patients.
For vaginal suppositories
Vaginal candidiasis;
Prevention of fungal complications with local antimicrobial therapy.
For rectal suppositories
Lower intestinal candidiasis;
Prevention of fungal infections in the pre- and postoperative periods.
Liver dysfunction;
Pancreatitis
Peptic ulcer and duodenal ulcer;
Pregnancy;
Hypersensitivity to the components of the drug.
From the digestive system: when taking the drug inside and using rectal suppositories, nausea, vomiting, diarrhea are possible.
Allergic reactions: itching, chills, fever.
Others: the risk of spreading resistant forms of fungi is possible, which requires discontinuation of the drug.
Overdose
Currently, no cases of overdose of the drug Nystatin have been reported.
special instructions
With the development of adverse reactions, the dose should be reduced or the drug should be discontinued.
During menstruation, you should not interrupt treatment with vaginal suppositories. In case of fungal diseases of the vagina, simultaneous treatment of the sexual partner is recommended. During the period of treatment, sexual intercourse should be avoided.
In case of liver dysfunction
Contraindicated in liver dysfunction.
Application during pregnancy and lactation
Nystatin is contraindicated in pregnancy.
Drug interactions
With the simultaneous use of nystatin and clotrimazole, the activity of the latter decreases.
At treatment of candidiasis of internal organs Nystatin is administered orally, regardless of food intake.
Adults appoint 500,000 IU 4-8 times / day.
At generalized candidiasis appoint up to 6,000,000 U / day.
Children aged 1-3 appoint 250,000 IU 3-4 times / day, over the age of 3- 250,000-500,000 units 4 times / day. The duration of treatment is 10-14 days. If necessary, repeat the course of treatment in a week.
At treatment of candidiasis of the skin and mucous membranes the ointment is applied in a thin layer to the affected areas 2 times / day, daily for 7-10 days. The use of the ointment can be combined with the intake of Nystatin inside.
Vaginal suppositories are inserted into the vagina after hygiene procedures, 1 suppository 2 times / day (morning and evening). The course of treatment is 10-14 days.
Rectal suppositories are injected deep into the rectum, 1 suppository 2 times / day (morning and evening). The course of treatment is 10-14 days.
If necessary, repeated courses of treatment are carried out.
Storage conditions and shelf life
List B. The drug in the form of tablets should be stored in a dry, dark place at a temperature of 18 ° -20 ° C. The drug in the form of an ointment, vaginal suppositories and rectal suppositories should be stored in a dry, dark place at a temperature not higher than 5 ° C. The shelf life of the drug in the form of tablets, vaginal suppositories, rectal suppositories is 2 years, the shelf life of the drug in the form of an ointment is 3 years. Conditions for dispensing from pharmacies The drug is dispensed by prescription.
The acute course of genital candidiasis is always accompanied by such unpleasant and obsessive symptoms as cramps during urination, a burning sensation in the external genital area and abundant thick discharge, reminiscent of cottage cheese in consistency. Therefore, as part of complex therapy, suppositories against thrush in women are prescribed without fail, since they well and quickly eliminate the clinical manifestations of the disease.
Local application of intravaginal suppositories allows you to achieve the elimination of the pathogen from the vaginal cavity and save a woman from the classic symptoms of candidiasis in a short time.
In addition, suppositories against thrush create an optimal concentration of the antifungal agent locally, practically not being absorbed into the systemic circulation. This greatly reduces the risk of severe adverse reactions.
Many vaginal drugs are combined drugs that have both antifungal and antibacterial effects. And, as you know, quite often thrush is activated or proceeds against the background of an existing bacterial infection in the vaginal cavity.
The presence of the patient obliges the appointment of both systemic and local antimycotic drugs, which are produced in the form of intravaginal suppositories.
There are situations when taking pills inside is extremely difficult due to the anatomical features of the oropharynx, injuries or concomitant pathology of the digestive system. In this case, the only treatment option is cream and ointment.
What are Nystatin suppositories?
Nystatin suppositories from thrush are a torpedo-like agent that has a yellow color. The suppositories themselves are enclosed in blister packs of 5 pieces.
The main active ingredient is nystatin, a polyene antifungal drug discovered in 1950. It is capable of not only suppressing growth, but also destroying fungal cells. The mechanism of action is to block specific enzymes that trigger sterol formation reactions. These substances belong to the basic components of the cell wall of the pathogen.
Auxiliary Ingredients:
- Witepsol 35.
- Lemon acid.
- Vaseline oil.
- Witepsol 15.
- Propyl ester of paraoxybenzoic acid.
Thus, the impaired biosynthesis of ergosterols contributes to an increase in the permeability of the cell membrane. As a result, a huge amount of sodium, potassium, chlorine and water ions enter the cell. As a result, the fungus does not stand up and disintegrates on its own.
Instructions for use for thrush
Gynecologists often recommend the use of the drug Nystatin in treatment, since microorganisms practically do not develop resistance to it. After passing a significant number of clinical trials, the drug has proven its effectiveness after many years of use.
The official instructions for the use of Nystatin suppositories for thrush contains the following categories:
- Release form.
- Beneficial features.
- Average therapeutic dosage and duration of therapy.
- Mode of application.
- Indications.
- Contraindications
- Adverse reactions.
Release forms and properties
The drug Nystatin can be represented by one or several dosage forms that differ in consistency and method of application:
- The tablets have a pale yellow color and a faint vanillin odor. Produced in a dose of 500 and 250 thousand units. They can be enclosed in a blister strip packaging (10 tablets each), a polymer or glass jar (20 pieces each).
- The ointment is yellow with a brownish tinge. Contains 30 g of active substance (1 gram - 100 thousand units), which is in an aluminum tube.
- Intravaginal suppositories containing 500 and 250 thousand units of nystatin.
- Rectal suppositories are also presented in a torpedo shape and contain 250 or 500 thousand units of the active substance.
Nystatin is a polyene antibiotic with a yellowish powder consistency. Has a pungent and strong odor, bitter taste and practically does not dissolve in water.
Thus, in order for nystatin to retain its medicinal properties, it should be stored under such conditions: in a sealed package, in a dark and cool place.
Due to mycostatic and mycidal effects, Nystatin acts on yeast-like fungi, including Candida, and Aspergillus, while it does not have activity against bacteria. Due to the spectrum of action, suppositories Nystatin are used in the treatment and prevention of fungal infections in women.
How to take: dosage and duration of therapy
Deep into the vaginal cavity with slow and gentle movements, 1 suppository is injected twice a day (in the morning and evening hours). The average therapeutic course of treatment usually lasts from 10 to 14 days.
As for rectal suppositories, it is possible to pose on the left side with the legs brought to the chest. Gently spread the buttocks with your fingers and slowly push the candle along the rectum. Also use a candle 2 times a day, it is desirable that the interval between use is 12 hours. The duration of therapy is 10-14 days.
Side effects and contraindications
Before using Nystatin against thrush, it is necessary to take into account the presence of contraindications and the possible development of adverse reactions.
Nystatin in any form of release is contraindicated in:
- Pregnancy of any period.
- Breastfeeding your baby.
- Individual hypersensitivity to individual components.
- History of acute or chronic pancreatitis.
- Severe liver pathology with impairment of its functions.
- Chronic peptic ulcer of the duodenum and stomach.
Adverse reactions are not numerous, but at the same time they have a place to be. Local application of the drug can cause moderate cutaneous, flushing, burning sensation and, less often, rashes. Generally, diarrhea, nausea, and abdominal pain are rare. Women prone to atopy may experience allergic reactions, up to anaphylactic shock.
Will nastatin candles give a result for thrush?
For the correct and effective prescription of an antifungal drug, the doctor must take into account the sensitivity of the pathogen to the active substance. For this, bacteriological sowing of pathological discharge is performed using a special medium.
The appearance of a certain number of colonies of yeast fungi from the genus Candida indicates a candidal infection. After determining the sensitivity of the seeded microorganism to various antifungal drugs.
Thus, if a woman, according to the analysis results, pathogenic fungi are sensitive to nystatin, its appointment will be correct and justified, and the effect will not be long in coming.
Price and where to buy?
It is not difficult to buy nystatin suppositories, since they are available in almost any pharmacy. The price depends on the form of release and the concentration of the active substance.
So, vaginal suppositories Nystatin 500 thousand units cost an average of 75 rubles, 250 thousand units can be purchased for 22-25 rubles. The pricing policy for rectal suppositories is also loyal - one pack costs about 50-80 rubles.
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