Asparkam is a drug that belongs to drugs that help regulate metabolic processes. With its help, the patient can restore electrolyte balance and regulate cardiac activity.
Before buying and starting to take it, read the instructions for it and consult your doctor, since taking Asparkam just for prevention is dangerous. Before starting treatment, you need to make sure that there is a lack of potassium in the body.
It is a highly absorbable drug.... Asparkam is excreted from the body by the kidneys. Overdose is possible both with too rapid administration of the drug, and with a significant increase in the recommended dose.
This medication is able to regulate electrolyte balance by improving the penetration of potassium and magnesium ions into the spaces between cells.
Its action reduces the conductivity and excitability of the myocardium, therefore, Asparkam can be attributed to antiarrhythmic drugs.
It also reduces sensitivity when taking glycosides.
The drug Asparkam: indications for use and contraindications
In case of disturbances in the work of the heart and hypokalemia, the doctor may prescribe Asparkam.
Indications for the use of this drug, which are indicated in the instructions:
- Insufficient blood supply to organs in heart failure.
- Atherosclerosis and ischemic heart disease, which developed with insufficient oxygen supply to the heart.
- Heart rhythm disorders of various etiology.
- Postponed myocardial infarction.
- Complications of glycoside overdose.
Asparkam is available as a solution in glass ampoules. Their volume can be different: 5 ml, 10 ml, 20 ml. They are packed in a dense cardboard box, laid with corrugated paper. An instruction is attached to the drug, which provides information on the indications and contraindications for taking the drug.
You can also find Asparkam tablets in the pharmacy. The indications for the use of this form of medication are similar, but it is not suitable for people with gastrointestinal problems.
Asparkam is prescribed if the patient is diagnosed with a deficiency of potassium and magnesium, as well as for heart disease. It is used if the patient has had a heart attack and with ischemic heart disease, as well as rhythm disturbances. It will be useful for chronic circulatory failure, and after conditions that lead to a lack of potassium and magnesium in the body.
The use of this drug can improve metabolic processes. It is used in the complex treatment of edema and seizures together with diuretics.
The effect of the drug on the body is due to its constituent potassium and magnesium, which have the ability to penetrate into the intercellular spaces.
Application for various purposes not indicated in the instructions is permissible if you know the principle of action of the drug and the characteristics of your body.
Asparkam can be used both in sports and for weight loss alone or in combination with other medicines:
- Asparkam and Riboxin. Asparkam is a drug that helps to quickly restore electrolyte balance. In addition to therapeutic and prophylactic purposes, it is used in bodybuilding. It can reduce fatigue, which can help you gain muscle faster. Its magnesium content is involved in protein metabolism and is a supplier of energy for muscle building. Athletes with the help of Asparkam have the opportunity to eliminate the lack of magnesium and potassium salts, the loss of which occurs during forced drying and weight loss. To increase endurance in bodybuilding, Asparkam is often used in combination with Riboxin. This complex of drugs allows you to increase the efficiency of training, protects and increases the productivity of the heart muscle. They are also used as prevention of cardiac arrest from overload and myocardial diseases.
- Asparkam can be useful for losing weight. In order to free the body from toxins, it is recommended to drink a lot of liquid, which washes away not only harmful substances, but also useful ones. With the help of Asparkam, you can replenish this supply and regulate the metabolism. Of course, before using the drug, it is better to consult a doctor, since it is not a dietary supplement.
- Asparkam can be used for a hangover, especially if alcohol abuse is persistent.
When taking the drug in order to replenish the ions of salts washed out from the body during training, poisoning and losing weight, it is better to take the medicine in tablets. Droppers and injections of the drug Asparkam, indications for the use of the drug are more related to the treatment of diseases and arrhythmias.
Prices for Asparkam, unlike Panangin, are much lower. It is analogous to this medicine and there are many positive reviews from people who have used it. The forum of Dr. Komarovsky also mentions the use of potassium and magnesium aspartate in pediatrics for infants with cysts and cerebral edema.
Asparkam medicine in medicine: how to take Asparkam for adults and children
One of the inexpensive and effective drugs in the pharmacy chain that can help maintain normal heart muscle and regulate metabolic processes in the body is the drug Asparkam.
How to take Asparkam, so that the course of treatment is of maximum benefit, will be prescribed by the doctor, having carefully studied the test results.
After all, this is not a dietary supplement and it is dangerous to take it without prescription, as this can lead to an excess of potassium in the body.
Asparkam medicine, as prescribed by a doctor, can be taken as part of complex therapy, including to neutralize an excess of cardiac glucosides.
Asparkam tablets are convenient enough for patients to take at home, since not everyone has the opportunity to organize intravenous drug administration.
How to take Asparkam for adults? The drug is prescribed 1 or 2 tablets 3 times a day. The course of treatment is 21-31 days. If necessary, you can go through it again.
A single oral dose for adults is not more than 500 mg. During this procedure, care must be taken to ensure that the medicine enters the body slowly. There can be a single or double dose of the drug per day, depending on the doctor's prescription. Intravenous fluids are given for treatment and, in rare cases, for prophylaxis. It is imperative to ensure that the injected liquid is clean and transparent. If, under any conditions, it becomes cloudy, then it should not be used under any circumstances.
Asparka child and baby
Taking the drug for infants can only be prescribed based on the results of tests by a doctor. First of all, with a potassium deficiency in the baby's body. For children, Asparkam is prescribed in the form of tablets, intravenous medication is administered only in exceptional cases, in particular when life is threatened.
It's important to watch your baby, because hypokalemia can be detected by symptoms such as weakness, drowsiness, low blood pressure, rhythm disturbances and palpitations. Also, dry skin and regurgitation may additionally appear.
For babies, the medicine Asparkam is prescribed if there is a need to take diuretics and glucocorticoids. It prevents the development of hypokalemia, a very dangerous condition for a baby.
Application during pregnancy and lactation
Unfortunately, expectant mothers and lactating women are not immune from health problems.
During pregnancy and lactation, it is important to know how to take Asparkam. This must be done very carefully and under the supervision of a physician.
It is prescribed for obvious violations or as part of complex therapy.
Just for prevention, taking this medication is not permissible. In some cases, it is prescribed to pregnant women to improve the functioning of the heart and with coronary artery disease, as well as to prevent potassium deficiency if a severe disorder has been observed.
The combination of the drug with diuretics is prescribed if you need to use strong diuretics, as well as in the complex therapy of hypertension and edema, including the brain. Diacarb and Furasemide are diuretics that help remove excess fluid from the body. Asparkam's task is to restore potassium and magnesium in the blood, which are washed out during this process.
The combination of drugs for a newborn is Diacarb and Asparkam. These two drugs are prescribed to newborns if there is severe brain dysfunction, brain cysts are present, and increased intracranial pressure is observed.
Also, these medications will help remove excess fluid from the ventricles of the brain. Diacarb is a means that removes excess fluid from the child's body, while Asparkam replenishes the level of potassium in the body in order to avoid serious complications, including cardiac arrest.
Asparkam: side effects and contraindications
If there are disturbances in metabolic processes or a deficiency of potassium and magnesium supplied with food, the doctor may prescribe Asparkam. Side effects are extremely rare, but the patient should be aware of them. Depending on whether it is injected intravenously or taken orally, there are slight differences in tracking negative reactions from the body.
If you plan to take Asparkam, contraindications should be studied very carefully in order to avoid causing harm to the body.
It is good to take Asparkam with saluretics and corticosteroids in order to avoid a decrease in the level of potassium in the body. It reduces the toxic effects of glucosides.
Asparkam should be used with caution with potassium-sparing diuretics and antidepolarizing muscle relaxants.
If anesthesia is planned and the patient is taking Asparkam. Side effects from their simultaneous use can be expressed in depression of the central nervous system and increased neuromuscular blockade.
Often, Asparkam is prescribed together with taking diuretics, including Furasemide. This is justified by the fact that their exposure can lead to the leaching of potassium and magnesium from the body. Their stocks must be replenished.
There are the following contraindications, in the presence of which the drug is prohibited:
- Individual sensitivity and intolerance to its components.
- Renal failure and other disorders of their work.
- Addison's disease or chronic adrenal cortex insufficiency.
- Increased levels of potassium and magnesium in the blood, since an excess of these trace elements is no better than a lack of them.
- If the patient is in a state of cardiogenic shock or atrioventricular block.
- Severe forms of myasthenia gravis.
Taking a course of drug treatment, you need to take care of organizing control over the content of trace elements in the blood, so as not to harm your body.
Asparkam is a potent medicine. It cannot be taken without a doctor's prescription. It does not affect the patient's alertness or ability to drive or perform activities requiring increased concentration.
Side effects of the drug are rare, but if you find the following reactions from the body, you need to stop taking the medicine and consult a doctor:
- Nausea, dry mouth and vomiting.
- Discomfort in the abdomen.
- Gastrointestinal bleeding.
- Hypotension.
- Violation of myocardial conduction.
- Paresthesia symptoms such as numbness and tingling sensation.
- Convulsions and decreased reflexes.
- The emergence of an allergy of uncertain etiology.
- Respiratory depression.
These side effects can occur if the drug is taken in case of oversaturation of the body with magnesium and potassium. To stop them, you need to cancel it and consult a doctor for advice on the appointment of therapy to neutralize unpleasant manifestations from the body.
An overdose of the drug is possible both with a significant increase in the recommended dose, and with too rapid intravenous administration. In this case, hyperkalemia and hypermagnesemia develop, which can be expressed in very unpleasant, and even life-threatening symptoms. When they appear, you need to stop taking Asparkam. Contraindications can play a decisive role, you should not ignore them. Hyperkalemia can be successfully treated with Resonium A.
An excess of potassium leads to an increase in muscle tone, arrhythmias up to cardiac arrest. There may also be paresthesia of the extremities.
An excess of magnesium can reduce pressure, including intracranial pressure, with depression of the respiratory center, which may be accompanied by convulsions and arrhythmias.
For the treatment of such a condition, calcium gluconate or calcium chloride is administered, the dose of which is determined depending on the severity of the patient's condition. Also, in parallel with this, the maintenance of the respiratory function is carried out, if necessary. In exceptional cases, hemodialysis is prescribed in order to correct the patient's condition and bring his body back to normal faster.
The drug Asparkam and its analogues
There is a wide selection of medicines in the pharmaceutical network. Many drugs have dozens of analogues. If you decide to replace one medicine with another, it is advisable to consult with your doctor in order to avoid misunderstandings. Since you may not know some of their features, which are not written in the instructions.
The drug Asparkam is a domestic analogue of Panangin. They contain salts of potassium and magnesium in a balanced combination. Panangin is used to treat angina pectoris, heart failure, arrhythmias and potassium deficiency. As a prophylactic agent, it is prescribed to strengthen and nourish the heart muscle.
Panangin is produced in the form of pills, covered with a protective membrane, which protects the mucous membrane from the effects of the active active substance. There is also an analogue of Asparkam, which can be purchased at the pharmacy, if necessary.
Asparkam is a generic drug of imported Panangin. It is believed that the degree of purification of raw materials is lower, therefore, it is cheaper. It is available in tablets, which imposes some restrictions on the intake of the drug for people with gastrointestinal problems.
Both drugs are recommended to be taken after meals. They have almost identical contraindications. In order to assimilate the magnesium that is part of their composition, vitamin B6 is additionally prescribed. Asparkam is produced by different pharmaceutical companies, which is reflected in the name of the drug.
Also, in case of hypokalemia, the doctor may prescribe the modern drug Kalinor.
Among the relative analogues of the drug Asparkam, Pamaton and Panangin can be distinguished. Although they also contain magnesium and potassium, it is present in a different dosage than Asparkam. Therefore, pay close attention to the doctor's prescription, as an excess of potassium is just as harmful as a lack of it. An analogue of Asparkam can be purchased, but it may be more expensive.
Depending on which pharmaceutical company produces the drug, prices for it may differ. The drug Asparkam of domestic production is not expensive and is available to almost any citizen who needs it. Some manufacturers can release the drug only in a certain form, since the production technology has only been developed for it.
Asparks can be bought freely in the network of pharmacies, but despite this, everyone should know that its uncontrolled use for the purpose of prevention is unacceptable. After examining the information on the Internet, numerous reviews of people who have used the drug in the presence of serious diseases and to improve metabolism, one can draw conclusions about the effectiveness of the drug.
It works great for cramps and puffiness. It also relieves the condition of people with certain heart diseases, for which it is indicated for use. If used for weight loss, it not only replenishes the balance of trace elements in the body, but also reduces cravings for sweets. There is also mention that the drug helped four-legged pets, in particular cats, which have had heart problems.
ASPARKAM Asparkam
Active substance
›› Potassium aspartate and magnesium aspartate
Latin name
›› A12CX Other mineral preparationsPharmacological groups: Macro- and microelements
››
Antiarrhythmic drugs
Nosological classification (ICD-10)
›› E87.6 Hypokalemia›› I20 Angina [angina pectoris]
›› I20.0 Unstable angina
›› I21 Acute myocardial infarction
›› I42 Cardiomyopathy
›› I49.9 Unspecified cardiac arrhythmia
›› R07.2 Pain in the region of the heart
›› T46.0 Poisoning with cardiac glycosides and drugs of similar action
Composition and form of release
1 tablet contains a mixture of potassium and magnesium asparaginate in a 1: 1 ratio (0.175 g each); in a glass jar 50 pcs.
pharmachologic effect
pharmachologic effect- antiarrhythmic, diuretic... Increases the content of potassium and magnesium ions in the cell, replenishes the deficiency of aspartic acid, stimulates oxidative phosphorylation and the formation of ATP, improves skeletal muscle tone and gastrointestinal motility (facilitates the release of acetylcholine).
Indications
Angina pectoris, cardiosclerosis, myocardial dystrophy, myocardial infarction, arrhythmias (including with absolute or relative hypokalemia, myocardial hypokalistidia, intoxication with cardiac glycosides). To replenish potassium losses during therapy with saluretics, laxatives, corticosteroids, vomiting, diarrhea.
Contraindications
Acute and chronic renal failure, hyperkalemia, hemolysis, acute metabolic acidosis, myasthenia gravis, impaired AV conduction (AV block II-III degree).
Side effects
Unpleasant sensations or burning sensation in the epigastric region (in patients with anacid gastritis or cholecystitis), hyperkalemia (nausea, vomiting, diarrhea, paresthesia); hypermagnesemia (facial flushing, thirst, decreased blood pressure, hyporeflexia, neuromuscular blockade, respiratory depression, convulsions).
Interaction
Improves the tolerance of cardiac glycosides; prevents and eliminates hypokalemia associated with the intake of various drugs (saluretics, corticosteroids, cardiac glycosides), enhances the effect of drugs that stimulate trophic processes in the myocardium.
Method of administration and dosage
Precautionary measures
It is necessary to constantly monitor the content of potassium in the blood plasma (for example, according to ECG data).
Shelf life
Storage conditions
In a dry place at room temperature.
* * *
ASPARCAM (Asparcam). Domestic drug corresponding to Panangin. It is produced in the form of tablets containing 0.175 g of potassium asparaginate and magnesium asparaginate (respectively 36.2 mg of potassium ion and 11.8 mg of magnesium ion), as well as in the form of a solution for injection in ampoules of 5 and 10 ml, containing 1 ml 0.045 g (45 mg) of potassium asparaginate and 0.04 g (40 mg) of magnesium asparaginate. According to indications and contraindications for use, it does not differ from panangin. Inside appoint adults 1 - 2 tablets 3 times a day after meals for 3 - 4 weeks. Intravenous 10-20 ml is injected 1 to 2 times a day for 5 days. The contents of 1 - 2 ampoules are pre-diluted in 100 - 200 ml of 5% glucose solution or sterile water for injection. Enter at a rate of 25 drops per minute. You can dilute the contents of 1 ampoule in 20 ml of 5% glucose solution or sterile water for injection and inject it in a stream (no more than 5 ml per minute). Method of production: tablets in a package of 50 pieces; in ampoules of 5 and 10 ml in a package of 10 ampoules. Storage: in a dark place.
Dictionary of Medicines. 2005 .
The last updated description by the manufacturer 04.06.2009
Filtered list
Active substance:
ATX
Pharmacological groups
Nosological classification (ICD-10)
Composition and form of release
in a contour acheikova packing 50 pcs .; in a pack of cardboard 1 packing.
Description of the dosage form
White tablets with a smooth surface, flat-cylindrical, scored.
pharmachologic effect
pharmachologic effect- metabolic, replenishing the deficiency of magnesium and potassium.Pharmacodynamics
Asparkam is a source of potassium and magnesium ions, regulates metabolic processes. The mechanism of action is presumably related to the role of asparaginate as a carrier of magnesium and potassium ions into the intracellular space and the participation of asparaginate in metabolic processes. Thus, Asparkam eliminates electrolyte imbalance, reduces myocardial excitability and conductivity (moderate antiarrhythmic effect).
Indications of the drug Asparkam
In the complex therapy of the following diseases and conditions:
heart failure;
hypokalemia;
cardiac arrhythmias (including with myocardial infarction, overdose of cardiac glycosides).
Contraindications
acute and chronic renal failure;
hyperkalemia.
Side effects
Possible nausea, discomfort or burning sensation in the epigastric region (with cholecystitis and anacid gastritis). These phenomena usually disappear with a decrease in the dose of the drug.
Interaction
Asparkam reduces the sensitivity to cardiac glycosides.
Method of administration and dosage
Inside, usually adults - 1-2 tables. 3 times a day after meals. The course of treatment is 3-4 weeks. It can be repeated if necessary.
Precautionary measures
In case of rhythm disturbances in combination with AV block, it is not recommended to prescribe the drug. The combined use of Asparkam and potassium-sparing diuretics increases the risk of hyperkalemia.
Storage conditions of the drug Asparkam
In a dry place, at a temperature of 15-25 ° C.Keep out of the reach of children.
Shelf life of the drug Asparkam
3 years.Do not use after the expiration date printed on the package.
Instructions for medical use
R N000383 / 01 dated 2012-05-21
Asparkam - instructions for medical use - RU No. LSR-005781/10 dated 2014-07-29
Asparkam - instructions for medical use - RU No. LS-002168 dated 2006-11-03
Asparkam - instructions for medical use - RU No. LSR-005781/10 dated 2012-09-11
Asparkam - instructions for medical use - RU No. LSR-008835/08 dated 2016-12-29
Asparkam - instructions for medical use - RU No. LSR-000025 dated 2009-12-25
Asparkam - instructions for medical use - RU No. LSR-008835/08 from 2017-11-22
Asparkam - instructions for medical use - RU No. LS-002168 dated 2013-07-24
Synonyms for nosological groups
| ICD-10 heading | Synonyms of diseases according to ICD-10 |
|---|---|
| E87.6 Hypokalemia | |
| Hypokalemic neuromuscular disorders | |
| Hypokalemia | |
| Hypokalemia with ketoacidosis | |
| Hypokalemia with saluretic treatment | |
| Myocardial hypokalistidia | |
| Potassium loss with saluretic therapy | |
| I20 Angina [angina pectoris] | Heberden's disease |
| Angina pectoris | |
| Angina attack | |
| Recurrent angina | |
| Spontaneous angina | |
| Stable angina | |
| Angina syndrome X | |
| Angina pectoris | |
| Angina pectoris (attack) | |
| Exertional angina | |
| Rest angina | |
| Progressive angina | |
| Mixed angina | |
| Spontaneous angina | |
| Stable angina | |
| Chronic stable angina | |
| I20.0 Unstable angina | Heberden's disease |
| Unstable angina | |
| Unstable angina | |
| I21 Acute myocardial infarction | Left ventricular infarction |
| Myocardial infarction without Q wave | |
| Acute myocardial infarction | |
| Non-transmural myocardial infarction (subendocardial) | |
| Acute myocardial infarction | |
| Myocardial infarction with and without pathological Q wave | |
| Myocardial infarction transmural | |
| Myocardial infarction complicated by cardiogenic shock | |
| Non-transmural myocardial infarction | |
| Acute phase of myocardial infarction | |
| Acute myocardial infarction | |
| Subacute stage of myocardial infarction | |
| Subacute period of myocardial infarction | |
| Subendocardial myocardial infarction | |
| Coronary artery (artery) thrombosis | |
| Threatening myocardial infarction | |
| I25.9 Chronic ischemic heart disease, unspecified | Ischemic heart disease |
| Coronary atherosclerosis in patients with coronary artery disease | |
| Insufficiency of coronary circulation | |
| I42 Cardiomyopathy | Myocardial hypokalistidia |
| Diffuse cardiomyopathy | |
| Diffuse non-obliterating cardiomyopathy | |
| Cardiopathy | |
| Myocardial dystrophy | |
| Acute cardiomyopathy | |
| Chronic cardiomyopathy | |
| I49.9 Unspecified cardiac arrhythmia | AV reciprocal tachycardia |
| AV nodal reciprocal tachycardia | |
| Antidromic reciprocal tachycardia | |
| Arrhythmias | |
| Arrhythmia | |
| Heart arythmy | |
| Arrhythmia due to hypokalemia | |
| Ventricular arrhythmia | |
| Ventricular tachyarrhythmia | |
| High ventricular rate | |
| Atrial tachysystolic arrhythmia | |
| Abnormal heart rhythm | |
| Heart rhythm disturbances | |
| Heart rhythm disorders | |
| Paroxysmal supraventricular arrhythmia | |
| Paroxysmal supraventricular arrhythmia | |
| Paroxysmal supraventricular tachycardia | |
| Paroxysmal rhythm disturbance | |
| Paroxysmal atrioventricular rhythm | |
| Precordial pathological pulsation | |
| Cardiac arrhythmias | |
| Supraventricular tachyarrhythmia | |
| Supraventricular tachycardia | |
| Supraventricular arrhythmias | |
| Tachyarrhythmia | |
| Extrasystolic arrhythmia | |
| I50.9 Heart failure, unspecified | Diastolic rigidity |
| Diastolic heart failure | |
| Cardiovascular insufficiency | |
| Heart failure with diastolic dysfunction | |
| Cardiovascular insufficiency | |
| R07.2 Pain in the region of the heart | Pain syndrome in myocardial infarction |
| Pain in cardiac patients | |
| Cardialgia | |
| Cardialgia against the background of dyshormonal myocardial dystrophy | |
| Cardiac syndrome | |
| Cardioneurosis | |
| Myocardial ischemic pain | |
| Heart neuroses | |
| Pericardial pain | |
| Pseudostenocardia | |
| Functional cardialgia | |
| T46.0 Poisoning with cardiac glycosides and drugs of similar action | Arrhythmia associated with digitalis intoxication |
| Glycosidic intoxication | |
| Digitalis arrhythmia | |
| Digitalis intoxication | |
| Cardiac glycoside intoxication | |
| Intoxication with cardiac glycosides and diuretics | |
| Poisoning with digitalis drugs | |
| Overdose or poisoning with digitalis glycosides |
Each element in the human body performs its own function. If you remove at least one of them, a serious failure will occur in all vital processes. When there is a loss of potassium, magnesium in the human body, it negatively affects the heart, metabolic processes and much more. Taking Asparkam indications for use, you will find out how this drug will affect the replenishment of important minerals. However, before using this drug, remember that you should not self-medicate without medical advice. All about this medication is below.
Asparkam is not only the normalization of the content of potassium and magnesium in the body. The specified drug restores the balance of electrolytes, thanks to the aspartic acid contained in it (it transfers the ions necessary for full life through the cell membrane). Read the detailed information on Asparkam's action and indications for use below.
- Prescribed at a very low content of potassium, magnesium in the body. In such cases, convulsions may occur. It is urgent to take this drug and the convulsions will stop.
- Increased or decreased heart rate due to a lack or excess of potassium with magnesium in the body.
- Atrial beat disorders.
- Cardiac arrhythmia.
- Prevention of diseases such as heart attack, heart failure or angina pectoris.
- Swelling of internal, external organs. If you combine the drug with "Furosemide", then it reduces the load on the heart, removes puffiness, reduces body weight.
- Severe post-alcoholic syndrome. Alcohol greatly dehydrates the body, and Asparkam helps to restore metabolic processes, electrolyte balance.
Release form
Asparkam is available in several forms:
- Tablet form. One tablet of the drug contains up to 175 mg of the active substance (magnesium aspartate with potassium aspartate). One package contains 10 or 50 tablets.
- Solutions for the administration of infusions (droppers). Contains up to 11.6 g of active ingredient. Available in 400 ml glass bottles.
- Ampoules for injections. The content of the main active agent in each ampoule (10 ml) of the drug is up to 0.4 g. Packaged in cardboard boxes of 5 or 10 ampoules (5, 10 or 20 ml).
pharmachologic effect
The potassium contained in the drug acts as an intracellular cation, which is found in the tissues of the human body. It has a direct effect on the heart muscle, its excitability (due to the ability to slow down excitability in myofibrils). The second active substance of Asparkam, magnesium, is directly involved in a huge complex of enzymatic reactions. Without this important mineral, normal growth and cell division are impossible. Thanks to Asparkam, as a source of potassium and magnesium ions, all these processes are restored.
Find out in more detail how the drug also affects the human body.
- Metabolic processes are gradually restored.
- The work of the heart muscle is normalized.
- The balance of electrolytes returns to normal.
- The excitability of the heart and its conduction are calmed down.
Dosage for use
As in other drugs, there is a certain dosage, which must be observed in a mandatory manner in order to avoid unwanted irreversible consequences. So, Asparkam, its indications for use in the following doses for adults and children:
- Tablet form - one or two tablets twice or three times (maximum) daily for half an hour before eating. Children from three years old - a quarter of one tablet, the maximum dose per day is 175 ml. The course of treatment is up to 10 days.
- The solution for infusion is administered using a drip method intravenously up to two times daily for adults and children. The route of administration is slow (25 drops / min). Adults are diluted with glucose, drip up to 20 ml of Asparkam per day. And for children - up to 10 ml at the same rate.
- If you use ampoules for injection, then Asparkam is administered intravenously at a rate not exceeding 5 ml / min. Up to two times a day for adults and children.
Contraindications
There is a whole list of diseases, symptoms, in the presence of which the use of Asparkam is strictly contraindicated. Check out each of them in more detail below:
- Renal failure (acute, chronic).
- Excess potassium (hyperkalemia).
- Excess magnesium (hypermagnesemia).
- Dehydration of the body (dehydration).
- High sensitivity, allergic intolerance to the active substances of the drug (potassium asparaginate, magnesium asparaginate).
- Hypersensitivity, even to drugs such as fructose or sorbitol.
- The exchange of amino acids is impaired.
- Addison's disease.
- Pregnancy, breastfeeding. However, there are special cases in which pregnant women are prescribed Asparkam (see below).
Side effects
Asparkam may have side effects. If you find the following symptoms after taking the drug, stop the course of treatment immediately and consult your doctor in order to avoid irreversible processes. Symptoms indicating a negative reaction of the body to taking the drug:
- Frequent gagging.
- The appearance of loose stools.
- Dry mouth.
- The appearance of flatulence.
- Dizziness, feeling of weakness.
- Feeling of muscle weakness.
- Allergic rash, itching.
- A sharp decrease in pressure in the artery.
- Excessive sweating.
- Respiratory disorders.
- Venous thrombosis.
Composition of the preparation
Interaction with other drugs
Asparkam can be used in combination with other medicines. You should be careful, since the active substance of this drug is not compatible with all medications. This can cause many undesirable consequences, side effects. Therefore, read in detail the list of medicines, the combination of asparkam with which is possible or strictly contraindicated:
- Asparkam is not required if you are using diuretics that contain potassium-sparing medicinal components.
- Cyclosporin. It also contains potassium-sparing components, therefore it is incompatible with Asparkam.
- Betta-blockers (similar to the previous drug).
- Asparkam can be combined with drugs that contain digitalis or strophanthin.
- If combined with drugs that contain tetracycline, sodium fluoride, iron, you will get the effect of reducing the toxic effects of cardiac glycosides on the myocardial muscle.
- The central nervous system is depressed if you combine Asparkam with anesthetic drugs.
- The effectiveness of antibiotics is significantly reduced if a person is taking asparkam in parallel.
Application during pregnancy and lactation
No negative effects were observed while taking asparkam by pregnant or lactating women. But it is recommended to avoid the need to use the drug during such a period. There are certain situations when doctors prescribe asparkam for complex therapy during pregnancy, if other methods have not helped. For example:
- Muscle tone of the uterus.
- Disruption of pregnancy.
- Preeclampsia of the uterus.
- Severe swelling of the limbs and other organs.
- Heart diseases.
- Lack of potassium.
- Irregular, complicated bowel movements (frequent constipation).
The cost of the drug
In Russia, the cost of the drug ranges from 49 rubles to 200 - it all depends on the form of release, the country of origin, etc. There are many analogs of asparkam ("Aspangin", "Panangin", for example), which have the only price difference and not always it is worth overpaying double or triple the cost. Check out the estimated prices for asparks below.
|
Manufacturer |
Name |
price, rub. |
|
Medisorb, Russia |
Asparkam |
|
|
"Avexima" JSC, Russia |
Asparkam Avexima |
|
|
"Farmak" PJSC, Ukraine |
Asparkam-Farmak |
|
|
"Gedeon Richter", Germany |
Panangin |
|
|
Berlin-Chemie, Germany |
Potassium and magnesium asparaginate for infusion |
|
|
"Biosintez" JSC, Russia |
Asparkam-L |
Prices are valid at the time of writing.
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Active substance: Potassium aspartate and magnesium aspartate A12CX Other mineral preparations Pharmacological groups Macro- and microelements in combinations Antiarrhythmic drugs in combinations Nosological classification (ICD-10) E87.6 Hypokalemia I25.9 Chronic ischemic heart disease, unspecified I49.9 Unspecified cardiac arrhythmia I50.9 Heart failure, unspecified T46.0 Poisoning with cardiac glycosides and drugs of similar action Composition and form of release in a contour acheikova packing 50 pcs .; in a pack of cardboard 1 packing. Description of the dosage form White tablets with a smooth surface, flat-cylindrical, scored. Pharmachologic effect Pharmacological action - metabolic, replenishing the deficiency of magnesium and potassium. Indications of the drug Asparkam In the complex therapy of the following diseases and conditions: heart failure; hypokalemia; cardiac arrhythmias (including with myocardial infarction, overdose of cardiac glycosides). Contraindications acute and chronic renal failure; hyperkalemia. Side effects Possible nausea, discomfort or burning sensation in the epigastric region (with cholecystitis and anacid gastritis). These phenomena usually disappear with a decrease in the dose of the drug. Interaction Asparkam reduces the sensitivity to cardiac glycosides. Method of administration and dosage Inside, usually adults - 1-2 tables. 3 times a day after meals. The course of treatment is 3-4 weeks. It can be repeated if necessary. Precautionary measures In case of rhythm disturbances in combination with AV block, it is not recommended to prescribe the drug. The combined use of Asparkam and potassium-sparing diuretics increases the risk of hyperkalemia. |
Lasix® (lasix®) Registration number:
P N014865 / 01-011108
Trade name of the drug: Lasix ®
International Non-Proprietary Name (INN)- furosemide
Dosage form:
pills
Composition One tablet contains: Active substance: furosemide (frusemide) - 40 mg Excipients: lactose, starch, pregelatinized starch; talc; colloidal silicon dioxide; magnesium stearate.
Description White or off-white round tablets with "DLI" engraved above and below notches on one side.
Pharmacotherapeutic group:
diuretic.
ATX code- С03СА01.
Indications for use
• edematous syndrome in chronic heart failure;
• edematous syndrome in chronic renal failure;
• acute renal failure, including that of pregnancy and burns (to maintain fluid excretion);
• edematous syndrome in nephrotic syndrome (in nephrotic syndrome, the treatment of the underlying disease is in the foreground);
• edematous syndrome in liver diseases (if necessary, in addition to treatment with aldosterone antagonists);
Arterial hypertension.
Contraindications
• hypersensitivity to the active substance or to any of the components of the drug; patients who are allergic to sulfonamides (sulfonamide antimicrobials or sulfonylureas) may be cross-allergic to furosemide;
Renal failure with anuria (in the absence of a reaction to furosemide);
• hepatic coma and precoma;
Severe hypokalemia;
• severe hyponatremia;
Hypovolemia (with or without arterial hypotension) or dehydration;
• pronounced violations of the outflow of urine of any etiology (including unilateral urinary tract damage);
digitalis intoxication;
• acute glomerulonephritis;
• decompensated aortic and mitral stenosis, hypertrophic obstructive cardiomyopathy;
increased central venous pressure (over 10 mm Hg);
hyperuricemia;
children under 3 years of age (solid dosage form);
• the period of breastfeeding.
Carefully: arterial hypotension; conditions in which an excessive decrease in blood pressure is especially dangerous (stenosing lesions of the coronary and / or cerebral arteries); acute myocardial infarction (increased risk of developing cardiogenic shock), latent or overt diabetes mellitus; gout; hepatorenal syndrome; hypoproteinemia, for example, in nephrotic syndrome, in which it is possible to reduce the diuretic effect and increase the risk of developing the ototoxic effect of furosemide, therefore, the dose selection in such patients should be carried out with extreme caution); violations of the outflow of urine (hypertrophy of the prostate gland, narrowing of the urethra or hydronephrosis); pancreatitis, diarrhea, history of ventricular arrhythmia, systemic lupus erythematosus.
Pregnancy and lactation Furosemide crosses the placental barrier, so it should not be prescribed during pregnancy. If, for health reasons, Lasix is prescribed to pregnant women, then careful monitoring of the condition of the fetus is necessary. During breastfeeding, taking furosemide is contraindicated. Furosemide suppresses lactation.
Method of administration and dosage General recommendations: The tablets should be taken on an empty stomach, without chewing and drinking a sufficient amount of liquid. When prescribing Lasix, it is recommended to use its smallest dose sufficient to achieve the desired effect. The recommended maximum daily intake for adults is 1500 mg. In children, the recommended oral dose is 2 mg / kg of body weight (but not more than 40 mg per day). The duration of treatment is determined by the doctor individually, depending on the indications.
Special recommendations for the dosage regimen in adults: Edema syndrome in chronic heart failure The recommended initial dose is 20-80 mg per day. The required dose is selected depending on the diuretic response. It is recommended that the daily dose be divided into two to three doses. Edema syndrome in chronic renal failure The natriuretic response to furosemide depends on several factors, including the severity of renal failure and blood sodium content, so the effect of the dose cannot be accurately predicted. In patients with chronic renal failure, careful dose selection is required, by gradually increasing it so that fluid loss occurs gradually (at the beginning of treatment, fluid loss up to about 2 kg of body weight per day is possible). The recommended starting dose is 40-80 mg per day. The required dose is selected depending on the diuretic response. The entire daily dose should be taken as a single dose or in two divided doses. In patients on hemodialysis, the usual maintenance dose is 250-1500 mg / day. Acute renal failure (to maintain fluid excretion) Before starting treatment with furosemide, hypovolemia, arterial hypotension and significant disturbances in the electrolyte and acid-base state should be eliminated. It is recommended to transfer the patient from the intravenous administration of Lasix to the administration of Lasix tablets as soon as possible (the dose of Lasix tablets depends on the selected intravenous dose). Edema in nephritic syndrome The recommended starting dose is 40 - 80 mg per day. The required dose is selected depending on the diuretic response. The daily dose can be taken in one dose or divided into several doses. Edema syndrome in liver diseases Lasix is prescribed in addition to treatment with aldosterone antagonists in case of their insufficient effectiveness. To prevent the development of complications, such as impaired orthostatic regulation of blood circulation or disturbances in the electrolyte or acid-base state, careful dose selection is required so that fluid loss occurs gradually (at the beginning of treatment, fluid loss up to about 0.5 kg of body weight per day is possible). The recommended starting dose is 20-80 mg per day. Arterial hypertension Lasix can be used alone or in combination with other antihypertensive drugs. The usual maintenance dose is 20-40 mg per day. In case of arterial hypertension in combination with chronic renal failure, the use of higher doses of Lasix may be required.
Side effect On the part of the water-electrolyte and acid-base state Hyponatremia, hypochloremia, hypokalemia, hypomagnesemia, hypocalcemia, metabolic alkalosis, which can develop in the form or a gradual increase in electrolyte deficiency or massive electrolyte loss for a very short time, for example, in the case of high doses furosemide in patients with normal renal function. Symptoms indicating the development of electrolyte and acid-base disorders may include headache, confusion, seizures, tetany, muscle weakness, cardiac arrhythmias, and dyspeptic disorders. Factors contributing to the development of electrolyte disturbances are underlying medical conditions (eg, cirrhosis of the liver or heart failure), concomitant therapy, and poor nutrition. In particular, vomiting and diarrhea may increase the risk of hypokalemia. Hypovolemia (decrease in circulating blood volume) and dehydration (more often in elderly patients), which can lead to hemoconcentration with a tendency to develop thrombosis. On the part of the cardiovascular system Excessive decrease in blood pressure, which, especially in elderly patients, can manifest itself with the following symptoms: impaired concentration and psychomotor reactions, headache, dizziness, drowsiness, weakness, visual disturbances, dry mouth, impaired orthostatic regulation blood circulation; collapse. From the side of metabolism Increase in serum cholesterol and triglyceride levels. Transient increase in the level of creatinine and urea in the blood, Increased serum uric acid concentration, which can cause or intensify the manifestations of gout. Decreased glucose tolerance (possible manifestation of latent diabetes mellitus). From the urinary system The appearance or intensification of symptoms caused by the existing obstruction to the outflow of urine up to acute urinary retention with subsequent complications (for example, with prostatic hypertrophy, narrowing of the urethra, hydronephrosis); hematuria, decreased potency. From the gastrointestinal tract Rarely - nausea, vomiting, diarrhea, constipation; isolated cases of intrahepatic cholestasis, increased levels of hepatic transaminases, acute pancreatitis. From the side of the central nervous system, organ of hearing In rare cases - hearing impairment, usually reversible, and / or tinnitus, especially in patients with renal failure or hypoproteinemia (nephrotic syndrome), rarely - paresthesia. Skin disorders, allergic reactions Rarely - allergic reactions: itching, urticaria, other types of rash or bullous skin lesions, erythema polymorphism, exfoliative dermatitis, purpura, fever, vasculitis, interstitial nephritis, eosinophilia, photosensitization. It is extremely rare - severe anaphylactic or anaphylactoid reactions up to shock, which until now have been described only after intravenous administration. From the peripheral blood Rarely - thrombocytopenia. In rare cases, leukopenia. In some cases, agranulocytosis, aplastic anemia or hemolytic anemia. Since some side effects (such as a change in the blood picture, severe anaphylactic or anaphylactoid reactions, severe allergic skin reactions) under certain conditions can threaten the lives of patients, if any side effects appear, you should immediately inform your doctor about them. Overdose If you suspect an overdose, it is imperative to consult a doctor, since in case of an overdose, it may be necessary to carry out certain therapeutic measures. The clinical picture of acute or chronic drug overdose depends mainly on the degree and consequences of fluid and electrolyte loss; overdose can be manifested by hypovolemia, dehydration, hemoconcentration, cardiac arrhythmias and conduction disturbances (including atrioventricular block and ventricular fibrillation). Symptoms of these disorders are arterial hypotension (up to the development of shock), acute renal failure, thrombosis, delirium, flaccid paralysis, apathy and confusion. There is no specific antidote. If after ingestion a little time has passed, then to reduce the absorption of furosemide from the gastrointestinal tract, you should try to induce vomiting or gastric lavage, and then take activated charcoal inside. Treatment is aimed at correcting clinically significant violations of the water-electrolyte and acid-base state under the control of serum electrolyte concentrations, indicators of acid-base state, hematocrit, as well as preventing or treating possible serious complications developing against the background of these disorders.
Interaction with other drugs Cardiac glycosides, drugs that cause lengthening of the QT interval - if electrolyte disturbances (hypokalemia or hypomagnesemia) develop while taking furosemide, the toxic effect of cardiac glycosides and drugs that cause lengthening of the QT interval increases (the risk of rhythm disturbances increases). Glucocorticosteroids, carbenoxolone, licorice in large quantities, and prolonged use of laxatives when combined with furosemide increase the risk of hypokalemia. Aminoglycosides - slowing the excretion of aminoglycosides by the kidneys when used simultaneously with furosemide and increasing the risk of developing ototoxic and nephrotoxic effects of aminoglycosides. For this reason, the use of this combination of drugs should be avoided except in cases where it is necessary for health reasons, and in this case, a correction (reduction) of maintenance doses of aminoglycosides is required. Medicines with nephrotoxic action - when combined with furosemide, the risk of developing their nephrotoxic action increases. High doses of some cephalosporins (especially those with a predominantly renal route of excretion) - in combination with furosemide, the risk of nephrotoxic action increases. Cisplatin - when used simultaneously with furosemide, there is a risk of developing an ototoxic effect. In addition, in the case of the joint appointment of cisplatin and furosemide in doses above 40 mg (with normal renal function), the risk of developing the nephrotoxic effect of cisplatin increases. Non-steroidal anti-inflammatory drugs (NSAIDs) - NSAIDs, including acetylsalicylic acid, can reduce the diuretic effect of furosemide. In patients with hypovolemia and dehydration (including those taking furosemide), NSAIDs can cause the development of acute renal failure. Furosemide can enhance the toxic effect of salicylates. Phenytoin - a decrease in the diuretic effect of furosemide Antihypertensive drugs, diuretics or other drugs that can lower blood pressure - when combined with furosemide, a more pronounced hypotensive effect is expected. Angiotensin-converting enzyme (ACE) inhibitors - the appointment of an ACE inhibitor to patients who have previously received treatment with furosemide can lead to an excessive decrease in blood pressure with deterioration of renal function, and in some cases - to the development of acute renal failure, therefore, three days before starting treatment with inhibitors With ACE or increasing their dose, it is recommended to cancel furosemide, or to reduce its dose. Probenicid, methotrexate or other drugs that, like furosemide, are secreted in the renal tubules, can reduce the effects of furosemide (the same pathway for renal secretion), on the other hand, furosemide can lead to a decrease in the excretion of these drugs by the kidneys. Hypoglycemic agents, pressor amines (epinephrine, norepinephrine) - weakening of the effects when combined with furosemide. Theophylline, diazoxide, curariform muscle relaxants - enhanced effects when combined with furosemide. Lithium salts - under the influence of furosemide, the excretion of lithium decreases, due to which the serum concentration of lithium increases and the risk of developing the toxic effects of lithium, including its damaging effects on the heart and nervous system, increases. Therefore, when using this combination, monitoring of serum lithium concentrations is required. Sucralfate - reducing the absorption of furosemide and weakening its effect (furosemide and sucralfate should be taken at intervals of at least two hours). Cyclosporin A - when combined with furosemide, the risk of developing gouty arthritis increases due to hyperuricemia caused by furosemide and impaired renal excretion of urate by cyclosporine. X-ray contrast agents - in patients with a high risk of developing nephropathy for the administration of X-ray contrast agents who received furosemide, there was a higher incidence of renal dysfunction compared with patients with a high risk of developing nephropathy for the administration of X-ray contrast agents who received only intravenous hydration before the administration of the X-ray contrast agent.
Forms of issue 40 mg tablets. 10 tablets in a strip of aluminum foil. 5 strips in a cardboard box along with instructions for medical use. 15 tablets in a strip of aluminum foil. 3 strips in a cardboard box along with instructions for medical use.
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