Hofitol is a herbal choleretic drug that also has diuretic and hepatoprotective properties.
The active ingredient is a dry water extract from the field artichoke (leaves) - Cynara scolymus. Biologically active substances have choleretic, hepatoprotective, diuretic effects.
It also helps to reduce serum urea levels. The drug increases the ability of hepatocytes to produce coenzymes, which improves the metabolism of cholesterol, lipids and the metabolism of ketone bodies.
With concomitant antibiotic therapy, it acts on the parenchyma of the kidneys and liver as a detoxification agent.
Inulin and B vitamins (B2, B1), included in the list of biologically active substances of the field artichoke, normalize metabolic processes in the body. Chophytol helps cleanse toxins, including nitro compounds, heavy metal salts and alkaloids.
The mechanism of action is due to the sum of the effects of all components, therefore, it is not possible to conduct a study of kinetic parameters and determine metabolites in the body using biological studies or markers.
Indications for use
What does Hofitol help from? According to the instructions, the drug is prescribed in the following cases:
- non-calculous cholecystitis in chronic form;
- hypokinetic biliary dyskinesia;
- chronic hepatitis;
- chronic nephritis;
- cirrhosis of the liver;
- renal failure in chronic form.
Instructions for use Hofitol, dosages
For adults, the drug is prescribed in 2-3 tablets or 2.5-3 ml of solution for oral administration 3 times / day. Take before meals.
The duration of the course of treatment is 2-3 weeks.
Children, depending on age, are prescribed 1-2 tablets \ 3 times / day before meals. If it is necessary to use Hofitol for children in the form of an oral solution, usually 1 / 4-1 / 2 of the dose used in adults is prescribed.
The need for repeated courses of drug therapy is established individually, depending on the indications.
According to the instructions for use, with prolonged use of Hofitol in high doses, the risk of diarrhea increases.
Side effects
The instruction warns of the possibility of developing the following side effects when prescribing Hofitol:
- allergic reactions;
- diarrhea.
As a rule, there are no side effects during treatment with the drug.
Contraindications
It is contraindicated to prescribe Hofitol in the following cases:
- acute cholecystitis;
- blockage of the lumen of the bile ducts with stones;
- the age of children under 6 years of age (for this dosage form);
- exacerbation of chronic diseases of the liver and urinary tract;
- individual intolerance to the components of the drug;
- pregnancy and the period of breastfeeding.
special instructions
Despite the fact that the tablets contain herbal ingredients, self-medication cannot be performed. Before starting therapy, it is imperative to make sure that there are no stones in the gallbladder and bile ducts. The presence of calculi in the gallbladder more than 5 mm in diameter can lead to blockage of the bile duct ducts and the development of an acute surgical condition requiring urgent surgical intervention.
The drug should not be taken during an exacerbation of chronic diseases of the liver, gallbladder and urinary tract.
Patients with hepatic impairment should always consult a doctor before starting therapy.
There is no experience with the use of Hofitol in the form of tablets among children under 6 years of age, and the safety of the drug has not been proven. Children under 6 years of age are prescribed in the form of drops for oral administration, according to the age dosage.
The drug does not have a depressing effect on the work of the central nervous system and does not inhibit the speed of psychomotor reactions.
Overdose
Treatment is symptomatic, it is possible to take enterosorbents.
Hofitol analogs, price in pharmacies
If necessary, you can replace Hofitol with an analogue for therapeutic action - these are drugs:
- Artichoke extract;
- Hepafitol;
- Hepatophyte;
- Holyver;
- Hollebil.
When choosing analogs, it is important to understand that the instructions for the use of Hofitol, the price and reviews for drugs of a similar action do not apply. It is important to consult a doctor and not make your own replacement of the drug.
Price in Russian pharmacies: Hofitol tablets 60 pcs. - from 320 to 380 rubles, 120 ml solution - from 350 to 475 rubles, according to 547 pharmacies.
Store at a temperature not exceeding 25 ° C in a place out of the reach of children. The shelf life, if all conditions are met, is 3 years for tablets and 4 years for solution.
With the development of physiological or pathological jaundice of newborns, special medications are prescribed - hepatoprotectors, which have a choleretic effect. These include Hofitol. What does the medicine consist of? Why is it prescribed to children in addition to jaundice? How to drink the remedy correctly? What are the analogues? Let's figure it out together.
Hofitol - composition, form of release and principle of action
The drug Hofitol is a hepatoprotector that promotes the excretion of bile from the body. The preparation is based on herbal ingredients. Field artichoke leaves in the form of a dried aqueous extract are included as the main active ingredient. The product is available in three forms:
- injection solution;
- oral solution;
- pills.
Chophytol is used to stimulate and activate biliary and biliary processes in the patient's body. The use of the medication in accordance with the instructions normalizes blood counts, including reducing the concentration of urea and cholesterol.
In what cases are different dosage forms prescribed?
In pediatric practice, Hofitol is widely used due to its effectiveness, a small list of contraindications and rare side effects.
The doctor prescribes different forms of medication based on the age category of the patient. Babies and babies under 6 years old are shown the use of the drug in the form of a solution - injectable or oral. Hofitol is prescribed to a child with:
- chronic kidney pathologies;
- chronic liver diseases, including pathological changes in the biliary tract;
- disorders of a dyspeptic nature.
Hofitol is also used in the treatment of uraturia, atherosclerosis, anorexia, obesity and chronic intoxication of the body, including salts of heavy metals and nitro compounds. In all these cases, the drug is prescribed together with other drugs as part of complex therapy.
Instructions for use for children
In most cases, the duration of taking Hofitol for a baby or an older child is 2-3 weeks. However, depending on the diagnosis, the severity of the disease, the individual characteristics of the organism of a small patient, the duration of the therapeutic course can be adjusted by the attending physician.
Pills
Teenagers over 12 years old can take Hofitol in an adult dosage - 1-2 tablets three times a day before meals. Schoolchildren and older preschoolers aged 6 to 12 years take one tablet three times a day.
The maximum daily dose of the active active ingredient for patients under the age of twelve is 600 mg.
Solution for preparation of injections
Solution for injection is the only form that is dispensed in pharmacies only with a doctor's prescription. Hofitol can be injected into the body of patients of any age, including newborns, both intramuscularly and intravenously:
- For adolescents from 15 years of age and older, an adult dosage is administered - 1-2 ampoules of the drug per day.
- For patients under 15 years of age, it is recommended to prescribe 0.25-0.5 doses of the older age category.
Oral solution
The doctor will recommend Hofitol for newborns and infants to be used in the form of a solution for oral administration (it is also called syrup or drops):
- From the first days of life, babies are given 5-10 drops of Hofitol, having previously dissolved the product in 5 ml of warm boiled water (this is a dosage for a single dose). Newborns and babies should be given a drop of water three times a day before feeding.
- Children aged 1 to 5 years - 10-20 drops, from 6 to 12 years old - 2-3 ml (half a teaspoon) of liquid Hofitol is dissolved in boiled water. The resulting solution is drunk 20 minutes before meals in the morning, at lunchtime and in the evening.
- The concentration of the drug in the solution for the treatment of adolescents over 12 years old should be higher. For a one-time admission in 1 tbsp. l. water dissolve 2.5-5 ml of the drug. Admission rules are similar to those recommended for young children.
Before taking the drug is mixed with warm boiled water according to the instructions. How does the drug interact with other medicines?
The manufacturer's instructions do not contain information on the interaction of Hofitol with other medicines, since the corresponding clinical studies have not been conducted. Chophytol for children in the form of an oral solution is not recommended to be used simultaneously with drugs that suppress the function of the central nervous system, since this form of the drug contains ethanol.
What are the contraindications and side effects?
The tablet form of the drug is contraindicated in babies under the age of six. It is impossible to take the medicine with pathological changes in the kidneys, liver, urinary and biliary tract. If the patient suffers from an individual intolerance to the field artichoke or other ingredients of the drug, then taking Hofitol is strictly prohibited to him.
In general, the drug is well tolerated by the child's body and is considered quite effective. In some cases, prolonged use of the drug causes hypersensitivity reactions in patients - itching appears, the skin turns red, edema, rash, urticaria occur.
If Hofitol is used for a long time in large quantities, the drug can also provoke a number of side effects. The most common of these are gastrointestinal disorders.
Hofitol should be used strictly observing the dosage prescribed by the doctor. In case of using the drug in overdose, an overdose is possible. It manifests itself through the enhancement of the above side effects. If these symptoms occur, it is recommended to consult a doctor and carry out symptomatic treatment.
Analogs of the remedy
The most popular analogue of Hofitol, which has a similar mechanism of pharmacological action, is Allochol. Also, with jaundice, newborn children are often prescribed Galsten's drug. This is a herbal remedy, but its components differ from those of Hofitol. Galstena in the form of drops can be used from the first days of life.
The choice of the drug is carried out by the doctor on an individual basis. The table below shows the most popular Hofitol analogues. In the event that pharmacies do not have a medicine recommended by a doctor, or taking Hofitol is impossible for other reasons, it is impossible to select its analogs on your own. It is recommended to consult a doctor who will select the most appropriate drug.
| Drug name | Dosage form | Active ingredient | Age restrictions |
| Hofitol | Tablets, solution (syrup), injection solution | Aqueous extract of field artichoke leaves | Solutions - from birth, tablets - from the age of six |
| Allohol | Tableted | Activated charcoal, dry bile, garlic and nettle extracts | Absent |
| Berberine | Tableted | Berberine bisulfate | Absent |
| Hepabene | Hard capsules | Medicinal herb smokyanka, fruits of milk thistle | From 18 years old |
| Galsten | Drops, sublingual tablets | Milk thistle, celandine, dandelion, sodium sulfate, phosphorus | Drops of Galsten inside can be used to treat children from birth. It can be difficult to give medicine to children because of the unpleasant taste. |
Benefits of treating jaundice with Hofitol in infants
Immediately after birth, the baby's liver does not function fully. For this reason, the concentration of toxic bilirubin in the blood of a newborn can significantly increase (we recommend reading :). If its amount exceeds the norm, the baby is diagnosed with physiological jaundice. The use of Hofitol or similar drugs is required to avoid negative effects on the brain.
The goal of jaundice therapy is to remove toxic substances from the patient's body or convert them into a non-toxic form, as well as stabilize and normalize the liver. For this reason, the treatment of pathology is often carried out with the use of Hofitol. Already after 7-8 days after the start of use, a visible improvement is noted, the baby recovers within 3 weeks.
The drug Hofitol is produced by the French pharmaceutical company "Rosa-Fitofarma" based on an extract from the leaves of the field artichoke (Cynara Scolymus), a rather inexpensive medication, but it effectively affects the liver, biliary tract and kidneys.
Thanks to the use of plant materials, Hofitol has few contraindications and side effects, mainly associated with the characteristics of diseases and individual susceptibility. The drug can be used both for medicinal purposes and as a prophylactic or symptomatic agent.
Due to the high content of biologically active substances (cynarin, ascorbic acid, phenolic acids, carotene, inulin, vitamins B1 and B2), the drug has a hepatoprotective and choleretic effect, has a mild diuretic effect, protects the liver and kidneys from toxic effects during antibiotic therapy. Accelerates the elimination of exogenous toxins (salts of heavy metals, radionuclides, alkaloids, etc.).
In chronic cholecystitis, Hofitol is used in courses - this leads to a timely outflow of bile from the gallbladder and the prevention of exacerbations of the disease. The use of a medication in the diagnosis of stones in the bile ducts and gallbladder is not allowed - an increased flow of bile can cause an exacerbation.
In the case of nephritis, the drug helps to liquefy and accelerate the excretion of bile or water in the body. As a result of the action of Hofitol, the required amount of bile enters the intestine, and the water is excreted in the form of urine.
Recently, quite often, Hofitol is prescribed to newborn children with jaundice as part of complex therapy. Thanks to the active component of the drug, the healing process proceeds much faster.
Even cosmetology has not ignored this wonderful drug. Today, Hofitol in the form of injections has been successfully used for mesotherapy.
Indications for use Hofitol
The instructions for use of Hofitol indicate the diagnoses and conditions for which the agent is prescribed. Recommended use for:
- chronic hepatitis, nephritis, cholecystitis;
- cirrhosis of the liver;
- chronic renal failure;
- fatty hepatosis of various origins (toxic, viral);
- atherosclerosis;
- a large amount of acetone in the blood;
- dyskinesia of the biliary tract;
- toxicosis in different trimesters of pregnancy;
- phytoplacental insufficiency and fetal growth retardation;
- a decrease in the daily amount of urine;
- obesity;
- fungal diseases of the skin and nails;
- psoriasis;
- belching, bloating, and nausea.
The use of Hofitol during pregnancy is widespread, the drug effectively copes with edema, eliminates dizziness, mood swings, general weakness in the body and drowsiness. During the course of taking chophytol in women, the general condition improves and the symptoms of asthenic syndrome decrease.
Instructions for use Hofitol, dosage
According to the instructions for use, Hofitol in the form of tablets is indicated for admission from the age of 18, 1-3 tablets (depending on the condition and body weight of the patient) 3 times a day. The duration of the course of drug use is 2-3 weeks.
Hofitol in the form of a syrup is applied before meals, 1 teaspoon (5 ml of solution) 3 times a day. The duration of the course of therapy is 21-28 days. Before using Hofitol, be sure to shake the syrup.
Intramuscular injections are applied once a day, 10 ml. The duration of the course is up to 15 days (in terms of indicators). When undergoing treatment in a hospital, it is possible to increase the daily dosage to 3 ampoules if the patient's condition worsens. The standard course of therapy is up to 10-14 days.
If you need to repeat the course of treatment, you should get medical advice.
Instructions and method of using Hofitol for children
For children, Hofitol is prescribed depending on age. Children over 6 years old, depending on age, are prescribed 1-2 tablets 3 before meals. Oral solution, depending on age, is prescribed 1 / 4-1 / 2 of the dose used in adults, 3 before meals. The course of treatment is 2-3 weeks.
For newborns, infants and young children, Hofitol is given only in the form of drops. However, older children also take drops. They are diluted in water and taken three times a day on an empty stomach.
- From birth to one year old - 5-10 drops in 5 ml of water.
- From one to 5 years old - 10-20 drops in 15 ml of water.
- From 6 to 12 years old - 40-60 drops (2-3 ml or half a teaspoon) in 15 ml of water.
- From 12 to 18 years old - 0.5-1 teaspoon in 15 ml of water.
The course of treatment with Hofitol in children is 2-3 weeks.
Contraindications to the use of the drug
- 1. cholelithiasis and obstruction of the biliary tract;
- 2. diseases of the liver, kidneys, bile and urinary tract in the acute phase (exacerbation);
- 3.Children's age up to 6 years (for tablets);
- 4. hypersensitivity to the active substance or components.
The use of Hofitol during pregnancy and lactation (breastfeeding) is possible only under the supervision of a physician.
Hofitol side effects
Allergic reactions like urticaria, pruritus, rashes.
Diarrhea may develop.
The drug Hofitol is widely used in urology, since it is able to activate the process of urination and increase the excretion of urea.
The latter process is especially important for combating intoxication of the body. In addition, the drug is useful for the liver and biliary tract. Also an important factor is good tolerance, a small number of side effects.
It is for these reasons that the drug has gained popularity in the treatment of pathologies of the urological and hepatological spectrum.
Composition and pharmacological action
The main active ingredient is artichoke extract. The tablets have excipients - talc, starch, magnesium stearate, gelatin, sucrose, wax. Liquid forms, in addition to the active ingredient, contain ethanol, water, dye, flavor enhancer, glycerol. 
The drug is herbal, belongs to hepatoprotectors and choleretic agents. In addition, artichoke extract enhances urinary excretion, activates lipid metabolism and general metabolism. The drug also has a good detoxifying effect.
Release form
Hofitol is produced in 3 forms - tablets, oral solution and injection solution. The pack can contain 60 and 180 tablets. The solution is produced in an amount of 120 ml in 1 bottle, for injection - 5 ampoules of 5 ml each.
Indications for use
Chophytol is necessary mainly for the treatment of pathologies of the urinary organs. The indications for its appointment are as follows:
With these pathologies, Hofitol will help to improve urinary excretion, and the drug also significantly improves metabolism, which prevents intoxication of the body due to the accumulation of kidney metabolites. This phenomenon is observed when the function of these organs is impaired:
- The medicine is used for various diseases of the biliary tract and liver - cholecystitis, dyskinesia, hepatitis of any etiology, fatty hepatosis, cirrhosis.
- Poisoning with various substances that cause intoxication of the patient (alcohol, chemicals, heavy metals).
As you can see, the range of indications is quite wide. As an additional agent, the drug is prescribed for the treatment of atherosclerosis and obesity.
Contraindications to use
Hofitol is not used in the presence of hyperreactivity reactions to its components, blockage of the bile ducts, acute pathologies of the urinary organs and liver.
The drug is not used for severe renal failure, stones in the biliary system. The remedy is not prescribed for children under the age of 6 years and with a violation of carbohydrate metabolism.
Drinking with alcohol
Doctors and pharmacologists have a negative attitude towards the joint use of this drug with alcoholic beverages, especially in cases of treating liver diseases.
If the patient neglects this rule, then the general condition of the patient deteriorates, the function of attention and concentration suffers.
Also, the danger is that taking Hofitol together with alcohol negatively affects liver function. The organ experiences additional serious stress, which is undesirable in the presence of hepatitis, cirrhosis or hepatosis.
Method of administration and dosage
It is important to note that Hofitol is used only according to indications and only as directed by a doctor. It is unacceptable to use the medicine on its own, since it can negatively affect the patient, cause unwanted reactions. 
For the solution, injections must be performed by trained medical personnel. Patients need 1-2 ampoules 3 times a day. The duration of use is the same as that of the previous types of medicine.
During pregnancy and breastfeeding
The drug can be prescribed during pregnancy and lactation, but under the supervision of medical professionals. It is important for women to remember that self-administration is unacceptable, it is necessary to have appropriate indications for the use of the drug.
For kids
As mentioned above, Hofitol is not used to treat children under 6 years of age. As for the rest, they are prescribed 1-2 tablets three times a day before eating food. On average, the course of therapy is 14-21 days.
Hofitol solution is used with the same frequency and duration as in adults. The difference lies in the dose of the medication.
It can be half the adult dose for patients over 12 years old and a quarter for children who are younger.
Danger of overdose
In case of an overdose of the drug, pronounced side reactions are observed. In such situations, it is recommended to wash the stomach to clean waters. You can take several tablets of enterosorbents (activated carbon, Smecta).
After that, you need to consult a doctor who will examine the patient, give the necessary recommendations and hospitalize him, if necessary.
Drug interactions
As mentioned above, the product contains a small amount of ethanol. This affects its joint use with some drugs of other groups, namely:
- cephalosporin antibiotics;
- antimycotics;
- cytostatics;
- hypoglycemic drugs.
When used together, patients may experience reactions in the form of hot flashes, increased heart rate, hyperemia, nausea and vomiting. For these reasons, the physician should be careful to avoid this situation.
Side effects
Chophytol is generally well tolerated. With prolonged use, the appearance of various reactions of hyperreactivity in the form of rashes can be observed, sometimes patients begin to be bothered by frequent loose stools.
Conditions and shelf life
Chophytol is available over the counter without a prescription (except for injection). The product is stored in a separate place with other medicines at temperatures up to 25 degrees.
The shelf life of the tablets is 3 years, the injectable solution is 2 years. The liquid form, which is drunk inside, is stored for 4 years. It is important to note that children should not have access to the drug.
Similar means
In pharmacy chains, you can buy analogues of this drug: Artihol (Ukraine), Fitokhol (Belarus), Artichoke extract (Russia).
The composition of these drugs is identical, the difference is in the manufacturers and the selling price.
Each patient decides on his own which medicine is more convenient for him to purchase - the French original or its analogues.
You should not replace the medicine yourself, it is imperative to consult a doctor.
Average price in pharmacies
The price in pharmacies ranges from 300-360 Russian rubles. This amount will have to be spent on the tablet form of the drug. As for the liquid variety, it is sold at a price of 370-470 Russian rubles.
Choleretic, choleretic drug is Hofitol. Instructions for use recommend taking 200 mg tablets, syrup, injections for the treatment of liver cirrhosis, chronic nephritis, biliary dyskinesia, chronic hepatitis.
Release form and composition
Hofitol is available in the form of an oral solution (syrup), injection solution and tablets.
The injections are delivered in glass ampoules (5 ml). The composition includes an active element - a thick aqueous extract of field artichoke leaves - 20 mg and auxiliary components.
The syrup is sold in glass bottles (120 ml). The composition contains a thick aqueous extract of field artichoke leaves - 20 mg and auxiliary components: ethanol, propyl parahydroxybenzoate, methyl parahydroxybenzoate, orange flavor, purified water, glycerol.
Hofitol tablets, instructions for use confirm this, are sold in blisters of 12 and 30 tablets. Their composition includes a thick aqueous extract of the leaves of the field artichoke - 200 mg.
pharmachologic effect
Chophytol includes components of plant origin. Tsinarin, which is part of the drug, has a choleretic and hepatoprotective effect. Contained in artichoke ascorbic acid, carotene, vitamins B1 and B2, inulin improve metabolic processes.
The agent has a diuretic effect and accelerates the excretion of urea.
What is Hofitol prescribed for?
Indications for use of the medication include:
- cirrhosis of the liver;
- chronic renal failure;
- chronic hepatitis;
- chronic non-calculous cholecystitis;
- chronic nephritis;
- dyskinesia of the biliary tract of the hypokinetic type.
Instructions for use
Hofitol for adult patients is prescribed in a dosage of 2.5-5 ml of solution or 2-3 tablets three times a day. The drug is taken before meals. The duration of therapy is 2-3 weeks.
For children over 6 years old, the drug is prescribed in a dosage of 1-2 tablets three times a day. The solution for children is prescribed at a dosage of ½ or ¼ of the recommended dose for adults. The course of therapy is 2-3 weeks.
The solution for injection is injected slowly intravenously or intramuscularly (injections). Shown 1-2 injections per day. The duration of treatment is 8-15 days. You can repeat the course only as directed by a doctor.
Contraindications
- children under 6 years of age (for tablets);
- cholelithiasis;
- hypersensitivity to the components of the drug Hofitol, from which the tablets and solution can cause side effects;
- acute diseases of the liver, kidneys, bile and urinary tract;
- obstruction of the biliary tract.
Side effects
- upset stomach;
- nausea;
- abdominal cramps;
- rashes on the skin;
- diarrhea;
- heartburn;
- itching, urticaria.
Children, during pregnancy and breastfeeding
The use of Hofitol during pregnancy and lactation (breastfeeding) is possible only under the supervision of a physician. Tablets are contraindicated in children under 6 years of age. 
special instructions
1 teaspoon of syrup contains 0.13 g of ethyl alcohol. This should be taken into account by people with alcohol dependence. At the beginning of treatment, an increase in blood cholesterol levels is possible. In the future, this indicator normalizes and even decreases.
Interaction
The drug interaction has not been described.
Analogues of the drug Hofitol
Analogs are determined by structure:
- Hollebil.
- Artichoke extract.
Vacation conditions and price
The average price of Hofitol (tablets No. 60) in Moscow is 268 rubles. In Kiev, you can buy a medicine for 128 hryvnia, in Kazakhstan - for 1720 tenge. Pharmacies in Minsk offer the drug for 14-15 BYN. rubles. Injections are available from pharmacies by prescription, tablets and syrup are free.
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