1. Sulfacyl sodium in eye drops.
2. Streptocide in ointment
3. Sulfadimezin tablets.
4. Sulfapyridazine tablets.
5. Phthalazole tablets.
6. Nitroxoline tablets (dragees).
7. Furazolidone tablets.
8. Ofloxacin tablets.
9. Bactrim
II Be able to choose and write in a prescription
1. Sulfanilamide for topical use.
2. A drug of the nitrofuran series for the treatment of intestinal infections.
3. Sulfanilamide for the treatment of dysentery.
4. Fluoroquinolone for the treatment of pneumonia.
Literature
1. Kharkevich D.A. Pharmacology, 9th ed., M., GEOTAR-Med, 2008.
2. Mashkovsky M.D. Medicines, 15th ed., M., Medicine, 2006.
Antimicrobial chemotherapeutic agents of different chemical groups: sulfonamides. Naphthyridines. 8-hydroxyquinolines. Quinolones. Nitrofurans. Quinoxalines
|
Drug name |
Forms of issue |
Mode of application |
|
Streptocide Streptocidum |
Powder 3 and 5 g Tablets 0.3 and 0.5 Ointment 5% or 10 ° / o at 30.0 Liniment 5% at 30.0 |
Apply to the wound surface For lubricating the skin For lubricating the skin |
|
Sulfacyl sodium * (Albucid) Sulfacylum- natrium (Albucidum) |
A solution of 10%, 20% and 30% (eye drops), 1.5 ml Ointment 30% at 10.0 Solution 30% in ampoules of 5 ml |
1-2 drops in the eye 3 times a day Place behind the lower eyelid 2 times a day 3-5 ml intravenously slowly 2 times a day |
|
Norsulfazole Norsulfazolum |
Tablets 0.25 and 0.5 |
At the first dose 2 g, then 1 g every 4 - 6 o'clock |
|
Sulfadimezin * Sulfadimezinum |
Tablets 0.25 and 0.5 |
At the first dose 2 g, then 1 g every 4-6 hours |
|
Urosulfan Urosulfanum |
Powder, tablets of 0.5 |
1-2 tablets 3 - 5 times a day |
|
Sulfapyridazine Sulfapiridazinum |
0.5 tablets |
2-4 tablets on the first day, then 1 - 2 tablets once a day |
|
Sulfadimethoxine Sulfadimethoxinum |
Tablets 0.2 and 0.5 |
By 2 - 4 tablets on the first day, then 1-2 tablets once a day |
|
Phthalazol * Phthalazolum |
0.5 tablets |
2 tablets every 4-6 hours |
|
Salazopyridazine Salazodipyridazinum |
0.5 tablets | |
|
Salazodimethoxin Salazodimethoxinum |
0.5 tablets |
1 tablet 4 times a day after meals |
|
Bactrimum |
Official pills |
1-2 tablets 2 times a day |
|
Sulfalen Sulfalenum |
Tablets 0.2 and 0.5 |
I. On the 1st day 1 g, then 0.2 per day (30 minutes before meals) II. 2.0 g 1 time in 7-10 days |
|
Nitroxoline * Nitroxolinum |
Tablets, dragee 0.05 |
2 tablets (pills) 4 times a day |
|
Nalidixic acid Acidum nalidixicum |
Tablets, capsules of 0.5 |
1-2 tablets (capsules) 4 times a day |
|
Ofloxacin * Ofloxacinum |
Tablets 0.1 and 0.2 Solution 0.2% in 100 ml vials Solution 0.3% (eye drops) 5 ml Eye ointment 0.3% in tubes of 3 g |
1-2 tablets 2 times a day. 100 ml intravenous drip 1-2 times a day 1-2 drops in the eye 3-4 times a day Place behind the lower eyelid 3-4 times a day |
|
Ciprofloxacin Ciprofloxacinum |
Tablets 0.1; 0.25; 0.5; 0.75 and 1 g Solution 0.2% in bottles of 50 and 100 ml Solution 0.3% (eye drops) 5 and 10 ml |
1 tablet 2 times a day 50-100 ml intravenous drip 1 time per day 1-2 drops in the eye every 4 hours |
|
Furazolidone * Furazolidonum |
Tablets 0.05 |
1-2 tablets 4 times a day after meals |
|
Furadonin Furadoninum |
Tablets 0.05 |
1-2 tablets 3-4 times a day |
|
Quinoxidine Chinoxidinum |
0.25 pills |
1 tablet 3 times a day after meals. |
TEST CONTROL ISSUES
For questions 1-31, match one answer indicated by letters
Specify the group of drugs:
1. Sulfadimezin. A. Group of sulfonamides.
2. Bactrim. B. Quinolone group.
3. Ofloxacin. C. Nitrofuran group.
4. Furazolidone. D. 8-hydroxyquinoline group.
5. Nalidixic acid. E. Quinoxaline group.
6. Phthalazol.
7. Ciprofloxacin.
8. Quinoxidine.
9. Sulfapyridazine.
10. Nitroxoline.
Note the nature of the effect on pathogens:
11. Bactrim. A - bactericidal.
12. Sulfadimezin. B - bacteriostatic.
13. Ofloxacin.
14. Nitroxoline.
15. Furazolidone.
16. Nalidixic acid.
Indicate which group it belongs to:
17. Urosulfan. A - short action.
18. Sulfalen. B - average duration of action.
19. Sulfapyridazine. C - long-acting.
20. Phthalazol. D - super long-term action.
21. Bactrim.
22. Sulfadimezin.
Mark the optimal interval between prescribing drugs:
23. Sulfapyridazine. A. 4 - 6 hours.
24. Phthalazol. B. 12 hours.
25. Urosulfan. S. 24 hours.
26. Bactrim.
27. Sulfadimethoxine.
28. Sulfadimezin.
Synthetic chemotherapeutic antibacterial drug of the sulfonamide group.
Sulfadimezin is rapidly absorbed and slowly excreted by the kidneys, as a result of which a high and constant concentration of the drug is created in the blood.
Indications for use
Sulfadimezin is used for streptococcal, meningococcal, pneumococcal, gonococcal, colibacillary infections, etc.
Sulfadimezin is used in the treatment of pneumonia, meningococcal meningitis, gonorrhea, sepsis, dysentery, toxoplasmosis (in combination with Chloridine).
Sulfadimezin is especially effective for pneumococcal diseases and urinary tract infections.
Application rules
The first time Sulfadimezin is given in a dose of 2 g, and then 1 g every 4-6 hours until the temperature drops. Taking the drug continues for the next three days.
- For treatment dysentery in adults Sulfadimezin is prescribed on the 1st and 2nd days of illness every 4 hours, 1 g, on the 3rd and 4th day - every 6 hours, 1 g, on the 5th and 6th day - every 8 hours for 1 g. After a 5-6-day break, the second cycle of treatment is carried out: on the 1st and 2nd day - 5 g of Sulfadimezin per day, on the 3rd and 4th days - 4 g per day, on the 5th day - 3 g per day.
- For treatment dysentery in children: for children under 3 years old, Sulfadimezin is prescribed at the rate of 0.2 g of the drug per day per 1 kg of the child's body weight for 7 days. The daily dose is given in 4 doses, without disturbing the night's sleep. Children over 3 years of age are prescribed 0.4-0.75 g (depending on age), 4 times a day.
- In case of pneumonia and meningitis, 2 g of Sulfadimezin is prescribed for the first dose; children at the rate of 0.1 g per 1 kg of body weight at the first dose, then 0.25 g / kg every 4, 6, 8 hours.
The highest dose of Sulfadimezin for adults inside: single - 2 g, daily - 7 g.
Side effects
Sulfadimezin is well tolerated by patients and less often than other sulfonamides, it causes complications from the urinary tract.
Sometimes nausea, vomiting, allergic reactions, leukopenia, agranulocytosis, crystalluria are possible.
Contraindications
Hypersensitivity to sulfonamides, diseases of the hematopoietic system, impaired renal function.
special instructions
When treating with Sulfadimezin, it is necessary to prescribe an abundant (2-3 liters per day) alkaline drink (Borjomi or ¼ – ½ teaspoon of baking soda in 1-2 glasses of water after each dose of the drug).
Composition and form of release
Produced by:
Recipe for Sulfadimezin
| Rp .: | Sulfadimezini | 0,5 |
| D. t. d. No. 6 in tabul. | ||
| S. | ||
- Tablets containing 0.25 g and 0.5 g of sulfadimezin, in packs of 6 and 10 tablets.
- Tablets of 0.25 g (for children) composition: sulfadimezin - 0.25 g, sugar - 1.4 g, chocolate - 0.54 g, citric acid - 0.005 g, fruit essence - 0.001 g, filler - 0.005 g.
- Powder (0.5 g).
Shelf life and storage conditions
Store with precautions (list B) in a dry, protected from light, out of reach of children.
The shelf life of Sulfadimezin is 10 years.
Properties
(Sulfadimezinum) - C 12 H 14 N 4 O 2 S - 4-amino-N- (4,6-dimethyl-2-pyrimidinyl) benzenesulfonamide - white or slightly yellowish powder, insoluble in water, easily soluble in dilute acids and alkalis ...
Melting point - 198–201 ° C. Molecular weight - 278.33.
Analogs
Azehetazine. Diazil. Diazol. Dimetasil. Dimetazine. Dimethyldibenal. Dimethylsulfadiazine. Dimethyldisulfazine. Dimethylsulfapyrimidine. Domian. Mezin. Paramizin. Pirmazin. Rigazol. Savazol. Sulmet. Sulfadine. Sulfadimerazine. Sulfadimethylpyrimidine. Sulfadimetine. Sulfadimidine. Sulfazine. Sulfaizanol. Sulfamezatin. Sulfamethazine. Sulfamidine. Sulfapil. Sulfaprocil. Sulfodimezine. Superseptile. Urazigol. Elkozin.
Release form:
Release form, description and composition
Pills color, white or white with a slightly yellowish tinge, flat-cylindrical, with a chamfer and a line.
Excipients: potato starch, talc, stearic acid, polysorbate 80.
Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
Tonsillitis;
Sinusitis;
Otitis media;
Exacerbation of chronic bronchitis;
Pneumonia;
Inflammatory diseases of the biliary and urinary tract;
Shigellosis;
Wound infection.
Refers to diseases:
- Bronchitis
- Sinusitis
- Infections
- Otitis
- Pneumonia
- Erysipelas
- Tonsillitis
- Shigellosis
Contraindications:
Hypersensitivity (including to other sulfonamides);
Oppression of bone marrow hematopoiesis;
Chronic renal failure
Azotemia;
Congenital deficiency of glucose-6-phosphate dehydrogenase;
Porphyria;
Children under 3 years old;
Hyperbilirubinemia in children (risk of developing bilirubin encephalopathy).
Carefully
Patients with impaired liver function, with a history of allergic diseases.
Method of administration and dosage:
It is taken internally.
Pneumonia
For adults- for 1 dose, 2 g is prescribed, then 1 g 4-6 times a day.
For children over 3 years old- 0.1 g / kg for the first dose, then 0.1-0.15 g / kg / day, divided into 4-6 doses.
The drug is stopped 2-3 days after the symptoms of the disease disappear.
Tonsillitis
For adults- 1 g 2-3 times a day;
For children over 3 years old- 0.05-0.075 g / kg / day, divided into 2-3 doses.
Duration of therapy: 5-7 days.
Sinusitis
For adults- 1 g 4-6 times a day;
For children over 3 years old
Otitis media
For adults- 1 g 2 times a day;
For children over 3 years old- 0.05-0.075 g / kg / day, divided into 2 doses.
Duration of therapy: 7-10 days.
Exacerbation of chronic bronchitis
For adults- 1 g 4-6 times a day;
For children over 3 years old- 0.1-0.15 g / kg / day, divided into 4-6 doses.
Duration of therapy: 10-14 days.
Inflammatory diseases of the biliary and urinary tract
For adults- 0.5 g 4-6 times a day;
For children over 3 years old
Duration of therapy: 7-10 days.
Shigellosis: 2 courses of treatment are carried out.
First course: 1 and 2 days - 1 g every 4 hours (total 6 g / day), 3 and 4 days - 1 g every 6 hours (4 g / day), 5 and 6 days - 1 g every 8 hours (3 g / day).
After 5-6 days, a second course is carried out: 1 and 2 days - 1 g every 4 hours, at night - after 8 hours (total 5 g / day), 3 and 4 days - 1 g after 4 hours (4 g / day, do not give at night), 5 day - 3 g / day.
Erysipelas
For adults- 1 g 4-6 times a day.
For children over 3 years old- 0.1-0.15 g / kg / day, divided into 4-6 doses.
Duration of therapy: 7-10 days.
Wound infections:
For adults- for 1 dose 2 g, then 1 g 4-6 times a day.
For children over 3 years old- 0.05-0.075 g / kg / day, divided into 4-6 doses.
The duration of therapy for a mild form is 5-7 days, for a severe form - about 10 days.
Higher doses
For adults: single - 2 g, daily - 7 g;
For children over 3 years old: daily - 0.1-0.15 g / kg.
Side effect:
Nausea, vomiting, crystalluria, allergic reactions, leukopenia, agranulocytosis.
Overdose:
Overdose data are not available.
Application during pregnancy and lactation:
The drug is contraindicated for use during pregnancy and lactation (breastfeeding).
Interaction with other medicinal products:
Reduces the effectiveness of bactericidal, antibiotics acting only on fissile microorganisms (including penicillins and cephalosporins).
Increases (mutually) hematotoxicity of chloramphenicol, thiamazole.
Benzocaine, procaine reduce the antimicrobial activity (para-aminobenzoic acid is released during hydrolysis).
Ascorbic acid, methenamine increase the risk of crystalluria.
Non-steroidal anti-inflammatory drugs, hypoglycemic drugs (sulfonylurea derivatives), phenytoin and coumarin anticoagulants increase the severity of side effects of the drug (leukopenia, agranulocytosis).
Antacids reduce intestinal absorption.
With toxoplasmosis, a combination with pyrimethamine is possible.
Myelotoxic drugs increase the manifestations of the drug's hematotoxicity.
Special instructions and precautions:
Adequate fluid intake should be ensured during treatment due to the risk of crystalluria.
With prolonged use, it is necessary to control the parameters of peripheral blood.
Influence on the ability to drive vehicles and control mechanisms
Does not affect driving vehicles and engaging in potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.
Storage conditions:
Store in a dry, dark place at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Trade name:
Sulfadimezin
International name:
Sulfadimidine
Group affiliation:
Antimicrobial agent, sulfonamide
Description of the active substance (INN):
Sulfadimidine
Dosage form:
pills
Pharmachologic effect:
Antimicrobial bacteriostatic agent, sulfonamide. The mechanism of action is due to competitive antagonism with PABA, inhibition of dihydropteroate synthetase, violation of the synthesis of tetrahydrofolic acid, which is necessary for the synthesis of purines and pyrimidines. Active against gram-positive and gram-negative cocci, Escherichia coli, Shigella spp., Klebsiella spp., Vibrio cholerae, Clostridium perfringens, Bacillus anthracis, Corynebacterium diphtheriae, Yersinia pestraelii, Chlamydia spp., Actinomydia spp., Actinomydia spp.
Indications:
Infectious and inflammatory diseases caused by sensitive microflora: pneumonia, gonorrhea, sepsis, dysentery, toxoplasmosis, tonsillitis, bronchitis, sinusitis, otitis media, inflammatory diseases of the biliary and urinary tract, erysipelas, wound infection.
Contraindications:
Hypersensitivity, inhibition of bone marrow hematopoiesis, chronic renal failure, hyperbilirubinemia in children (risk of developing bilirubin encephalopathy), congenital deficiency of glucose-6-phosphate dehydrogenase, porphyria, azotemia, pregnancy, lactation period.
Side effects:
Nausea, vomiting, crystalluria, allergic reactions, leukopenia, agranulocytosis.
Method of administration and dosage:
Inside, 1 g 4-6 times a day. For pneumonia and meningitis at the first dose - 2 g; children - at the rate of 0.1 g / kg for the first dose, then 0.25 g / kg every 4, 6, 8 hours. Higher doses for adults: single - 2 g, daily - 7 g; for children under 1 year old daily - 0.15 g / kg, over 1 year old daily - 0.1-0.15 g / kg. With dysentery, 2 courses of treatment are carried out. The first course: on days 1 and 2 - 1 g every 4 hours (total 6 g / day), 3 and 4 days - 1 g every 6 hours (4 g / day), 5 and 6 days - 1 g every 8 hours ( 3 g / day). After 5-6 days, a second course is carried out: 1 and 2 days - 1 g every 4 hours, at night - after 8 hours (total 5 g / day), 3 and 4 days - 1 g after 4 hours (4 g / day, do not give at night), 5 day - 3 g / day.
Special instructions:
Interaction:
Reduces the effectiveness of bactericidal antibiotics acting only on fissile microorganisms (including penicillins and cephalosporins). Increases (mutually) hematotoxicity of chloramphenicol, thiamazole. Benzocaine, procaine reduce the antimicrobial activity (PABA is released during hydrolysis). Ascorbic acid, hexamethylenetetramine increase the risk of crystalluria. NSAIDs, hypoglycemic drugs (sulfonylurea derivatives), phenytoin and coumarin anticoagulants increase the severity of side effects. Antacids reduce intestinal absorption. With toxoplasmosis, a combination with pyrimethamine is possible. Myelotoxic drugs increase the manifestations of the drug's hematotoxicity.
The description of the drug Sulfadimezin is not intended for prescribing treatment without the participation of a doctor.
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Antibacterial sulfa drug
Active substance
Sulfadimidine
Release form, composition and packaging
Pills color, white or white with a slightly yellowish tinge, flat-cylindrical, with a chamfer and a line.
Excipients: potato starch, talc, stearic acid, polysorbate 80.
10 pieces. - contour cell packaging (2) - cardboard packs.
10 pieces. - non-cell contoured packaging (500) - cardboard boxes.
pharmachologic effect
- otitis media;
- exacerbation of chronic bronchitis;
- pneumonia;
- inflammatory diseases of the biliary and urinary tract;
- shigellosis;
- wound infection.
Contraindications
- hypersensitivity (including to other sulfonamides);
- oppression of bone marrow hematopoiesis;
- azotemia;
- congenital deficiency of glucose-6-phosphate dehydrogenase;
- porphyria;
- children's age up to 3 years;
- hyperbilirubinemia in children (risk of developing bilirubin encephalopathy).
Carefully
Patients with impaired liver function, with a history of allergic diseases.
Dosage
For adults- for 1 dose, 2 g is prescribed, then 1 g 4-6 times a day.
For children over 3 years old- 0.1 g / kg for the first dose, then 0.1-0.15 g / kg / day, divided into 4-6 doses.
The drug is stopped 2-3 days after the symptoms of the disease disappear.
Tonsillitis
For adults- 1 g 2-3 times a day;
For children over 3 years old- 0.05-0.075 g / kg / day, divided into 2-3 doses.
Duration of therapy: 5-7 days.
Sinusitis
For adults- 1 g 4-6 times a day;
For children over 3 years old
Otitis media
For adults- 1 g 2 times a day;
For children over 3 years old- 0.05-0.075 g / kg / day, divided into 2 doses.
Duration of therapy: 7-10 days.
Exacerbation of chronic bronchitis
For adults- 1 g 4-6 times a day;
For children over 3 years old- 0.1-0.15 g / kg / day, divided into 4-6 doses.
Duration of therapy: 10-14 days.
Inflammatory diseases of the biliary and urinary tract
For adults- 0.5 g 4-6 times a day;
For children over 3 years old
Duration of therapy: 7-10 days.
Shigellosis: 2 courses of treatment are carried out.
First course: 1 and 2 days - 1 g every 4 hours (total 6 g / day), 3 and 4 days - 1 g every 6 hours (4 g / day), 5 and 6 days - 1 g every 8 hours (3 g / day).
After 5-6 days, a second course is carried out: 1 and 2 days - 1 g every 4 hours, at night - after 8 hours (total 5 g / day), 3 and 4 days - 1 g after 4 hours (4 g / day, do not give at night), 5 day - 3 g / day.
Erysipelas
For adults- 1 g 4-6 times a day.
For children over 3 years old- 0.1-0.15 g / kg / day, divided into 4-6 doses.
Duration of therapy: 7-10 days.
Wound infections:
For adults- for 1 dose 2 g, then 1 g 4-6 times a day.
For children over 3 years old- 0.05-0.075 g / kg / day, divided into 4-6 doses.
The duration of therapy for a mild form is 5-7 days, for a severe form - about 10 days.
Higher doses
For adults: single - 2 g, daily - 7 g;
For children over 3 years old: daily - 0.1-0.15 g / kg.
Side effects
Nausea, vomiting, crystalluria, allergic reactions, leukopenia, agranulocytosis.
Overdose
Overdose data are not available.
Drug interactions
Reduces the effectiveness of bactericidal, antibiotics acting only on fissile microorganisms (including penicillins and cephalosporins).
Increases (mutually) hematotoxicity of chloramphenicol, thiamazole.
Benzocaine, procaine reduce the antimicrobial activity (para-aminobenzoic acid is released during hydrolysis).
Methenamine increases the risk of developing crystalluria.
Non-steroidal anti-inflammatory drugs, hypoglycemic drugs (sulfonylurea derivatives), phenytoin and coumarin anticoagulants increase the severity of side effects of the drug (leukopenia, agranulocytosis).
Reduces intestinal absorption.
With toxoplasmosis, a combination with pyrimethamine is possible.
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