Possibilities of ursosan in the complex treatment of hepatitis C. Ursosan

Ursosan tablets are a modern and highly effective hepatoprotective agent with a powerful hypocholesterolemic and cholelitic effect. What does the medicine help for? The drug also has hypolipidemic, choleretic and immunomodulating properties. Means "Ursosan" instructions for use suggest taking with gallstone disease, cirrhosis, hepatitis.

Active ingredients and form of release

In the pharmacy network, the pharmacological agent "Ursosan", the instructions for use note this, is presented in the form of gelatin capsules, with a whitish coloration. Inside packed fine-granular or compressed active ingredient in powder form in combination with inactive ingredients.

The main active chemical component of the drug "Ursosan", from which it helps with liver diseases, is ursodeoxycholic acid, 250 mg of volume in each capsule. It is he who is inherent in the above effects - cholelitic, hypolipidemic and choleretic.

Of the auxiliary substances in the instructions are listed: colloidal silicon dioxide and starch from corn, magnesium stearate and gelatin, as well as titanium dioxide.

Pharmacological effects

Since the drug "Ursosan" is a representative of hepatoprotectors, it contributes to a significant improvement in the activity of hepatocytes, the following pharmacological effects are inherent in it:

hypocholesterolemic;
choleretic;
hypolipidemic;
cholelitic;
poorly expressed immunomodulatory.

Due to the existing high polar qualities, ursodexycholic acid is able to form specific micelles with toxic bile components localized in the human body. Against this background, the ability of gastric refluctate to injure cell membranes decreases with a person's already existing reflux gastritis or biliary reflux esophagitis.

It is observed in ursodeoxycholic acid and the ability to form double molecules, then included in the membranes of cholangocytes, as well as epithelial cells of the structures of the gastrointestinal tract and hepatocytes. This perfectly stabilizes them and increases their resistance to the negative effects of micelles.

The active component of the drug "Ursosan", from which the volume of bile acids, which have a very negative effect on the hepatic structures, is optimally reduced, powerfully helps to eliminate the intrahepatic variant of cholestasis. There is also a stimulating effect on cholerases oversaturated with bicarbonates.

There is a decrease in the absorption of cholesterol in the intestinal loops, as well as inhibition of synthesis in the hepatic structures, minimization of the saturation of bile with negative cholesterol. As a result, against the background of medication therapy, bile formations dissolve.

Tablets "Ursosan": what helps the medicine

Self-medication with the drug "Ursosan" is prohibited, its reception should be recommended by a specialist. It is the doctor who assesses whether there are indications for therapy with a hepatoprotective agent.

The instructions indicate a list of indications:

gallstone pathology, proceeding without severe complications;
prevention of exacerbation of the formation of gallstones after cholecystectomy;
acute hepatitis;
biliary cirrhosis;
alcoholic form of cirrhosis;
formed dyskinesia of biliary structures;
cystic fibrosis of the liver;
dyspeptic biliary syndrome complex;
severe toxic damage to the hepatic structures;
chronic variant of hepatitis;
non-alcoholic form of steatohepatitis;
formed atresia of intrahepatic structures;
sclerosing variant of cholangitis;
biliary form of reflux gastritis;
exacerbated reflux esophagitis;
prevention of liver disorders, for example, with prolonged forced intake of hormonal medications, contraceptives.

The frequency of admission and the total duration of the therapeutic effect are determined by the specialist individually - based on the severity of the symptoms, the severity of the patient's condition, his age category and susceptibility to the medication. Control laboratory tests are required.

Contraindications

Like any pharmacological agent, the drug "Ursosan", the instructions for use informs about this, has a list of absolute as well as relative contraindications:

the presence of calcium salts in gallstones;
"Disabled" gallbladder;
decompensated course of cirrhosis;
pathology of the gallbladder and bile ducts at the time of exacerbation;
severe violations of the activity of the hepatic structures;
period of gestation and subsequent lactation of the baby;
severe disorders in the functioning of the renal structures;
individual hyperreaction to the active and auxiliary components of the drug "Ursosan", from which the tablets can cause allergies;
children's category up to three years.

According to individual indications, the drug "Ursosan" can be used with a woman's pregnancy - if the estimated benefit of drug therapy will exceed the possible consequences for the child.

The drug "Ursosan": instructions for use

The manufacturer of the drug "Ursosan" is intended for oral administration, with the obligatory drinking of liquid.

For various hepatopathologies, the frequency and duration of the therapeutic course are determined by the gastroenterologist individually:

With gallstone pathology - a daily dose of 10-15 mg / kg of body weight, which is equivalent to 3-5 capsules, the total duration can range from 3.5-6 months to 2-3 years. Reception, as a rule, one time, before a night's rest. In case of gallstone pathology, the medication is taken until the dissolution of the stones is confirmed by hardware examination. With the subsequent continuation after a break - with a preventive purpose. To prevent calculi from forming again.
With diffuse lesions of the liver structures, the daily dose of the drug recommended by a specialist is divided into 2 doses. The medicine is taken orally, immediately after meals. Duration - up to 10-12 months.
After cholecystectomy, as well as for the prophylactic purpose of preventing recurrent cholelithiasis, 250 mg twice a day is recommended. The treatment course is presumably at least 3.5-5.5 months.
With biliary cirrhosis, the medication is recommended for taking 10-15 mg / kg of body weight. If necessary, the dose is increased to 20 mg / kg. Then it is divided into 3 receptions. The total duration of the treatment course is 6-18 months.
With the non-alcoholic form of steatohepatitis - 13-15 mg / kg per day, for 2 doses, for a long time.
With biliary reflux gastritis or reflux esophagitis, the drug is recommended to be taken at 250 mg per day. Reception before night rest. Therapy can last either 10 days or 6 months. According to individual indications - up to two to three years.
With revealed atresia of the biliary tract and other pathological lesions of the liver, as well as alcoholic disease of hepatocytes, the daily dose is 10-15 mg / kg, with a course of 8-12 months.
In the case of sclerosing cholangitis, the medication is recommended by a specialist, as a rule, at a dose of 12-15 mg / kg per day. If necessary, the specialist can increase the dose to 20 mg / kg. The daily dose must be divided into 2 doses. The total duration of drug therapy ranges from 6 months to 2-3 years.
In cystic fibrosis, a hepatoprotective agent is recommended at 20-30 mg / kg per day, in two doses, up to 2-3 years.
The exact recommendations for taking the medication will be given by the specialist during the consultation.

Instructions for taking Ursosan capsules in pediatrics

In pediatric practice, specialists allow children to take the drug "Ursosan" after reaching the age of two. The number of capsules is selected for each child individually, as a rule, it is 10-20 mg / kg of the baby's weight.

Less commonly, in order to eliminate severe and life-threatening jaundice, the medication is recommended for newborns. The total duration of treatment is 2.5-4 weeks. Dosage for newborns - no more than a quarter of the capsule per day. The powder is removed from the capsule, poured onto a saucer and distributed into 4 parts.

One part is given to the baby in dissolved form, for example, in breast milk. Monitoring of blood parameters is mandatory. Bilirubin during treatment should be reduced by at least 50 units per week. After reaching its parameters of 100 mg / ml, the medication is canceled.

Analogues of the drug "Ursosan"

The same active substance composition contains analogs:

"Ursodez".
"Ursodeoxycholic acid".
"Urdoksa".
"Urso 100".
Choludexan.
Exhol.
"Ursorom Rompharm".
"Ursorom S."
"Ursodex".
"Ursoliv".
Ursofalk.

Price

You can buy Ursosan capsules in Moscow for 200 rubles. Their price in Minsk reaches 38-48 BYN. rubles. In Kiev, the drug is sold in pharmacies for 585 hryvnia. The cost of the drug in Kazakhstan is 7045 tenge.

In this article, you can read the instructions for using the medicinal product. Ursosan... The reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Ursosan in their practice are presented. A big request is to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, which may not have been declared by the manufacturer in the annotation. Ursosan's analogs in the presence of existing structural analogs. Use for the treatment of hepatitis, jaundice, cirrhosis and other liver diseases in adults, children (including newborns), as well as during pregnancy and breastfeeding.

Ursosan- hepatoprotector. It also has choleretic, cholelitholytic, hypolipidemic, hypocholesterolemic and some immunomodulatory effects.

Possessing high polar properties, ursodeoxycholic acid forms non-toxic mixed micelles with apolar (toxic) bile acids, which reduces the ability of gastric refluctate to damage cell membranes in biliary reflux gastritis and reflux esophagitis. In addition, ursodeoxycholic acid forms double molecules capable of being incorporated into the cell membranes of hepatocytes, cholangiocytes, gastrointestinal epithelial cells, stabilizing them and making them immune to the action of cytotoxic micelles.

By reducing the concentration of bile acids toxic to hepatocytes and stimulating choleresis rich in bicarbonates, ursodeoxycholic acid effectively helps to resolve intrahepatic cholestasis. Reduces the saturation of bile with cholesterol by inhibiting its absorption in the intestine, suppressing synthesis in the liver and decreasing secretion into bile; increases the solubility of cholesterol in bile, forming liquid crystals with it; reduces the lithogenic index of bile. The result is the dissolution of cholesterol gallstones and the prevention of new calculus formation.

The immunomodulatory effect is due to inhibition of the expression of HLA-1 antigens on the membranes of hepatocytes and HLA-2 on cholangiocytes, normalization of natural killer activity of lymphocytes, etc. Reliably delays the progression of fibrosis in patients with primary biliary cirrhosis, cystic fibrosis and alcoholic steatohepatic disease; reduces the risk of developing esophageal varicose veins. Ursodeoxycholic acid slows down the processes of premature aging and cell death (hepatocytes, cholangiocytes).

Composition

Ursodeoxycholic acid (ursodeoxycholic acid) + excipients.

Pharmacokinetics

Ursodeoxycholic acid is absorbed from the small intestine through passive diffusion (about 90%), and in the ileum through active transport. Plasma protein binding is high - up to 96-99%. Penetrates the placental barrier. With the systematic intake of Ursosan, ursodeoxycholic acid becomes the main bile acid in the blood serum and makes up about 48% of the total amount of bile acids in the blood. The therapeutic effect of the drug depends on the concentration of ursodeoxycholic acid in bile. It is metabolized in the liver (clearance during primary passage through the liver) into taurine and glycine conjugates. The resulting conjugates are secreted into bile. About 50-70% of the total dose of the drug is excreted in the bile.

Indications

uncomplicated gallstone disease: biliary sludge; dissolution of cholesterol gallstones in the gallbladder, if it is impossible to remove them by surgical or endoscopic methods; prevention of recurrence of stone formation after cholecystectomy;
chronic active hepatitis;
acute hepatitis;
toxic (including medicinal) liver damage;
alcoholic liver disease;
non-alcoholic steatohepatitis;
primary biliary cirrhosis of the liver;
primary sclerosing cholangitis;
cystic fibrosis (cystic fibrosis) of the liver;
atresia of the intrahepatic biliary tract (including congenital atresia of the bile duct);
dyskinesia of the biliary tract;
biliary reflux gastritis and reflux esophagitis;
biliary dyspeptic syndrome (with cholecystopathy and biliary dyskinesia);
prevention of liver damage when using hormonal contraceptives and cytostatics.

Forms of issue

Capsules 250 mg (there is no tablet form).

Instructions for use and dosage regimen

Ursosan capsules are taken orally with plenty of water.

For diffuse liver diseases, cholelithiasis (cholesterol gallstones and biliary sludge), the drug is prescribed continuously for a long time (from several months to several years) at a daily dose of 10 mg / kg of body weight to 12-15 mg / kg (2- 5 capsules).

With diffuse liver diseases, the daily dose of Ursosan is divided into 2-3 doses, the capsules are taken with food.

With gallstone disease, the entire daily dose is taken once at night. The duration of taking the drug for dissolving stones is until complete dissolution, and then another 3 months to prevent recurrence of stone formation.

With biliary reflux gastritis and reflux esophagitis, the drug is prescribed at 250 mg (1 capsule) per day, before bedtime. The course of treatment is from 10-14 days to 6 months, if necessary - up to 2 years.

After cholecystectomy, for the prevention of recurrent cholelithiasis, the recommended dose is 250 mg 2 times a day for several months.

For toxic, medicinal liver damage, alcoholic liver disease and atresia of the biliary tract, the daily dose is set at the rate of 10-15 mg / kg per day in 2-3 doses. The duration of therapy is 6-12 months or more.

In primary biliary cirrhosis, the drug is prescribed at the rate of 10-15 mg / kg per day (if necessary, up to 20 mg / kg) in 2-3 doses. The duration of therapy is from 6 months to several years.

With primary sclerosing cholangitis - 12-15 mg / kg per day (up to 20 mg / kg) in 2-3 doses. The duration of therapy is from 6 months to several years.

With non-alcoholic steatohepatitis - 13-15 mg / kg per day in 2-3 doses. The duration of therapy is from 6 months to several years.

With cystic fibrosis, the dose is set at the rate of 20-30 mg / kg per day in 2-3 doses. The duration of therapy is from 6 months to several years.

For children over the age of 2 years, the dose of the drug is set individually at the rate of 10-20 mg / kg per day.

Side effect

nausea, vomiting;
diarrhea (may be dose dependent);
constipation;
calcification of gallstones;
backache;
allergic reactions;
exacerbation of previously existing psoriasis;
alopecia.

Contraindications

X-ray positive (high calcium) gallstones;
non-functioning gallbladder;
bile-gastrointestinal fistula;
acute cholecystitis;
acute cholangitis;
cirrhosis of the liver in the stage of decompensation;
liver failure;
renal failure;
obturation of the biliary tract;
acute infectious diseases of the gallbladder and bile ducts;
empyema of the gallbladder;
hypersensitivity to the components of the drug.

Application during pregnancy and lactation

The use of ursodeoxycholic acid during pregnancy is possible only when the expected benefit to the mother outweighs the potential risk to the fetus (adequate, strictly controlled studies of the use of ursodeoxycholic acid in pregnant women have not been conducted).

There are currently no data on the excretion of ursodeoxycholic acid in breast milk. If it is necessary to use ursodeoxycholic acid during lactation, the question of stopping breastfeeding should be resolved.

special instructions

When using the drug in order to dissolve gallstones, the following conditions must be met: the stones must be cholesterol (X-ray negative), their size must not exceed 15-20 mm, the gallbladder must remain functional and must be filled with stones no more than half, the patency of the cystic and the common bile duct must be preserved.

With long-term (more than 1 month) taking the drug every 4 weeks in the first 3 months of treatment, then - every 3 months, a biochemical blood test should be performed to determine the activity of hepatic transaminases. Monitoring the effectiveness of treatment should be carried out every 6 months according to ultrasound of the biliary tract.

After complete dissolution of the stones, it is recommended to continue using Ursosan for at least 3 months in order to help dissolve the remains of stones, the size of which is too small for their detection and to prevent recurrence of stone formation.

In experimental studies on animals, no mutagenic and carcinogenic effects of ursodeoxycholic acid were detected.

Drug interactions

When used together, antacids containing aluminum and ion exchange resins (colestyramine) reduce the absorption of UDCA.

With the simultaneous use of lipid-lowering drugs (especially clofibrate), estrogens, neomycin or progestins increase the saturation of bile with cholesterol and may reduce the ability of UDCA to dissolve cholesterol gall stones.

Analogs of the drug Ursosan

Structural analogues for the active substance:

Urdoks;
Urso 100;
Ursodez;
Ursodeoxycholic acid;
Ursodex;
Ursoliv;
Ursor Rompharm;
Ursor C;
Ursofalk;
Choludexane;
Exhol.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and see the available analogues for the therapeutic effect.

From this medical article, you can familiarize yourself with the drug Ursosan. The instructions for use will explain in which cases the medicine can be taken, what it helps from, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can leave only real reviews about Ursosan, from which it is possible to find out whether the medicine helped in the treatment of hepatitis, jaundice, cirrhosis and other liver diseases in adults and children. The instructions list Ursosan analogues, drug prices in pharmacies, as well as its use during pregnancy.

Ursosan is a hepatoprotective drug with hypocholesterolemic, cholelitholytic, hypolipidemic, choleretic, immunomodulatory action. Instructions for use recommend taking capsules or tablets of 250 mg and 500 mg for the treatment of gallstone disease, acute hepatitis, biliary dyskinesia, cystic fibrosis of the liver, alcoholic liver diseases.

Release form and composition

Ursosan is produced in the following dosage forms:

Capsules: white, gelatinous, with an opaque solid structure, powder content. 1 capsule contains: active ingredient: ursodeoxycholic acid - 250 mg and auxiliary components.
Film-coated tablets: almost white or white, oblong biconvex shape. 1 tablet contains: active substance: ursodeoxycholic acid - 500 mg.

pharmachologic effect

As a hepatoprotector, Ursosan, the instructions for use confirm this, also produces hypolipidemic, choleretic, hypocholesterolemic, cholelitholytic and mild immunomodulatory effects.

Due to its high polar properties, ursodeoxycholic acid is capable of forming mixed non-toxic micelles with toxic (apolar) bile acids, which reduces the ability of gastric refluctate to destroy cell membranes in reflux esophagitis and biliary reflux gastritis.

Ursodeoxycholic acid forms double molecules that are included in the cell membranes of cholangiocytes, hepatocytes, gastrointestinal epithelial cells, stabilize them and make them resistant to the effects of cytotoxic micelles.

Also, the drug actively promotes the resolution of intrahepatic cholestasis, reducing the level of bile acids, toxic to hepatocytes, and exerting a stimulating effect on choleresis rich in bicarbonates.

Also, by reducing the absorption of cholesterol in the intestine, inhibiting synthesis in the liver and minimizing secretion in bile, ursodeoxycholic acid reduces the saturation of bile with cholesterol. As a result, cholesterol gallstones dissolve.

What does Ursosan help from?

Indications for the use of Ursosan medication include:

chronic active hepatitis;
non-alcoholic steatohepatitis;
acute hepatitis;
uncomplicated gallstone disease: biliary sludge; dissolution of cholesterol gallstones in the gallbladder, if it is impossible to remove them by surgical or endoscopic methods; prevention of recurrence of stone formation after cholecystectomy;
primary biliary cirrhosis of the liver;
primary sclerosing cholangitis;
prevention of liver damage when using hormonal contraceptives and cytostatics;
biliary dyspeptic syndrome (with cholecystopathy and biliary dyskinesia);
biliary reflux gastritis and reflux esophagitis;
toxic (including medicinal) liver damage;
dyskinesia of the biliary tract;
cystic fibrosis (cystic fibrosis) of the liver;
alcoholic liver disease;
atresia of the intrahepatic biliary tract (including congenital atresia of the bile duct).

Instructions for use

Ursosan in capsules or tablets is taken with food, without chewing, drinking plenty of water.

If necessary, the tablet is divided in half at the risk, if it breaks into unequal parts, they should not be used. If you hold a broken tablet in your mouth, it tastes bitter.

With biliary reflux gastritis and reflux esophagitis, the daily dose is 250 mg (1 capsule or 0.5 tablets) and is taken once at night. The course lasts from two weeks to 6 months on average, if necessary, the drug can be taken up to 2 years.
With cholesterol gallstones, 10 mg per 1 kg of body weight is indicated. The maximum dose is 12-15 mg per kg. The daily dose is taken once at night. The course is 6-12 months or until the stones are completely dissolved. If the stones do not decrease within 12 months of treatment, the drug is discontinued. In the prevention of re-formation of stones, the drug is taken within several months after their complete dissolution.
With dyskinesia of the biliary tract, the daily dose is 10 mg per 1 kg of body weight and is divided into 2 doses. The course lasts 2-8 weeks, repeated if necessary.
For cholestatic liver diseases, primary sclerosing cholangitis, cystic fibrosis, the drug is prescribed at a dose of 12-15 mg per 1 kg of body weight (the maximum dose is 20-30 mg per kg). In the first 3 months of admission, the daily dose is divided into 2-3 doses. When the biochemical parameters of the blood improve, the drug is taken once at night. The course lasts from 6 months to several years.
For chronic hepatitis, chronic viral hepatitis, non-alcoholic fatty liver disease, alcoholic liver disease, the hepatoprotector is prescribed at a dose of 10-15 mg per 1 kg of body weight, divided into 2-3 doses. The course lasts 6-12 months or more.
In the prevention of recurrence of cholelithiasis after cholecystectomy, the drug is prescribed in a dose of 250 mg (1 capsule or 0.5 tablets) 2 times a day for several months.

Ursosan for children over the age of 2 years is given in a dosage that is set individually at the rate of 10-20 mg per 1 kg per day.

Contraindications

Ursosan instruction prohibits if the patient has:

hypersensitivity to the components of the drug;
lactation period;
renal failure;
obturation of the biliary tract;
cirrhosis of the liver in the stage of decompensation;
acute cholangitis;
bile-gastrointestinal fistula;
acute cholecystitis;
liver failure;
non-functioning gallbladder;
X-ray positive (high calcium) gallstones;
empyema of the gallbladder;
acute infectious diseases of the gallbladder and bile ducts.

Side effects

alopecia;
allergic reactions;
backache;
nausea, vomiting;
constipation;
diarrhea (may be dose dependent);
exacerbation of previously existing psoriasis;
calcification of gallstones.

Children, during pregnancy and breastfeeding

During pregnancy, Ursosan is prescribed if the expected benefit to the mother outweighs the potential risk to the fetus. There are no data on the excretion of the drug in milk. During the period of taking the drug, breastfeeding is recommended to be discontinued.

Ursodeoxycholic acid has no age restrictions for use. Difficulties arise when swallowing capsules and tablets, therefore, the drug is prescribed with caution to children from 2 to 4 years old, the drug is not recommended for children under 2 years old.

special instructions

When treating gallstone disease, it should be borne in mind that the stones should be cholesterol in size no more than 15-20 mm, and the gallbladder should remain functional, filled with stones no more than half, while maintaining the patency of the cystic and common bile ducts.

Taking Ursosan for more than 1 month requires monitoring the biochemical blood test and the activity of hepatic amines. Tests are carried out every 4 weeks in the first 3 months and then once every 3 months. Efficiency control by ultrasound is carried out every six months.

Drug interactions

The absorption of the drug is reduced when taken simultaneously with antacids containing aluminum and ion exchange resins.

Lipid-lowering drugs, estrogens, neomycin and progestins reduce the ability of ursodeoxycholic acid to dissolve cholesterol stones.

Analogues of the drug Ursosan

Analogues in structure include:

Choludexan.
Ursodez.
Ursoliv.
Ursorom Rompharm.
Ursofalk.
Exhol.
Ursodex.
Ursor S.
Urdoks.
Urso 100.
Ursodeoxycholic acid.

Vacation conditions and price

The average price of Ursosan (250 mg capsules No. 50) in Moscow is 700 rubles. In Kiev, you can buy pills for 580 hryvnia, in Kazakhstan - for 5990 tenge. Pharmacies in Minsk offer Ursosan capsules (No. 50) for 37-38 BYN. rubles. Dispensed from pharmacies with a prescription.

The pharmaceutical drug "Ursosan" is prescribed for hepatitis C and other liver pathologies, due to its ability to protect hepatocytes from the negative effects of external factors. The protective effect is due to the various properties of "Ursosan", which are aimed at improving the outflow of bile, normalizing the functioning of the hepatic organ and dissolving calculi. Ursosan should be used to heal the liver after consultation with a specialized doctor, who, in turn, on the basis of a diagnostic examination, will establish a diagnosis and, in accordance with it, prescribe treatment.

Release form and active ingredient

The drug "Ursosan" is produced in the form of white capsules with a solid structure. Contains the active ingredient - ursodeoxycholic acid (UDCA) and such additional components:

aerosil;
food additive E572;
bone glue;
corn starch;
food coloring E171.

Mechanism of action

The drug has a stimulating effect on the immune system.

The medical product "Ursosan" with ursodeoxycholic acid in the composition has a hepatoprotective effect and is used as a complex treatment for liver restoration, improvement of bile outflow and the breakdown of calculi. Ursosan operates in this way:

displaces toxic substances;
dissolves "bad" cholesterol;
reduces stagnation of bile in the liver tissues;
stimulates the immune system;
acts as a defense for the normal cells of the body from harmful influences.

The mechanism of action on the liver of the hepatoprotector "Ursosan" is achieved due to its abilities:

restore cell membranes by eliminating inflammatory processes;
reduce the concentration of toxic substances in the hepatocyte;
prevent the pathological development of connective tissues.

In addition, the hepatoprotector "Ursosan" has the ability to prevent aging and death of liver cells. It prevents damage to cell membranes, which provokes the throwing of bile into the stomach, stimulates the process of dissolution of gallstones, frees the intrahepatic ducts from the accumulation of bile and stops the proliferation of connective tissue in the liver that occurs with cirrhosis and other ailments.

Indications

Recommend taking medication in the treatment of hepatitis.

It is recommended to take "Ursosan" at the initial stage of cholelithiasis, active acute and chronic hepatitis, cystic fibrosis, when hepatocytes are exposed to various poisons, drugs, everyday chemistry, and in liver diseases arising from alcohol abuse. Indications for the use of "Ursosan" are also:

cholestasis of pregnant women;
bile in the stomach;
replacement of normal liver tissue with scar tissue;
fatty hepatosis;
prevention of liver damage when using cytostatic drugs and hormonal contraceptives;
impaired motility, decreased tone of the gallbladder and bile ducts.

How to take Ursosan for liver treatment

It is better to take the medicine "Ursosan" to heal the liver with meals, with a large amount of water. Capsules are not crushed before taking, but swallowed whole. To achieve the maximum effect of the treatment, the medication is drunk regularly, strictly adhering to the scheme selected by the doctor. The duration of the treatment course and the dosage of "Ursosan" are determined by the specialized physician. So, when prescribed at 0.01-0.15 g / kg per day, divided into 3 doses. Patients with cholesterol gallstones are prescribed "Ursosan" at the rate of 10 mg / kg per day. The course lasts from 6 months to 2 years, but if after a year the difference in the size of dense cholesterol formations does not appear, then the therapy is stopped.

Achievement of the maximum effect depends on the correctly selected dosage regimen.

At the beginning of treatment with "Ursosan", the level of activity of hepatic enzymes should be monitored monthly, and throughout the course, changes in the size of stone formation should be monitored using an X-ray examination of the gallbladder using a contrast agent or ultrasound. In addition, studies are carried out that allow timely detection of calcium salt deposits on calculi and, if calcified neoplasms are detected, treatment is stopped.

Patients with bile reflux gastritis are prescribed "Ursosan" 1 capsule per day. The duration of the treatment course is from 10 to 14 days and can be increased at the discretion of the doctor. Persons with biliary cirrhosis are advised to drink ursodeoxycholic acid at 14 mg / kg per day. In the first days of treatment, the dosage of "Ursosan" is divided into 3 doses, most of the medicine is left in the evening. When the liver condition improves, the dose is reduced to 1 capsule and it is drunk before bedtime 1 r. / Day.

Is it possible for pregnant women and with hepatitis B?

It is allowed to use "Ursosan" to eliminate liver problems for women in a position, if the expected benefit for the expectant mother is much higher than the possible risk for an unborn baby. The expediency of using "Ursosan" is determined by a specialized physician, based on the results of a laboratory study of a woman's biological fluids and her general health. To date, there is no data on the release of the active component of the hepatoprotector "Ursosan" in breast milk. If you need to use ursodeoxycholic acid at the time of breastfeeding, you should stop lactation.

Is it allowed for small patients?

For the smallest patients, a solution is made from a capsule of the drug.

Medication "Ursosan" is prescribed for the treatment of various ailments of the liver, starting from 2 years. The dosage is calculated depending on the weight of the baby and the diagnosis. The daily dose of the drug is 0.01-0.02 g / kg at a time, preferably at bedtime. Babies who cannot swallow the whole Ursosan capsule open it, and pour the contents into a vessel with water. It is important that the baby drinks the medicinal solution to the end.

Features of admission for hepatitis C

Serious liver pathology of an inflammatory nature - hepatitis C, increases the risk of developing malignant organ tumors and promotes the replacement of cellular structures with fibrous tissue, which subsequently leads to liver cirrhosis. Ursodeoxycholic acid prevents the growth of scar tissue and reduces the rate of development of cirrhosis.

It should be understood that "Ursosan" does not heal the liver, it helps to maintain its normal functioning and cleanses the organ of accumulated toxins. "Ursosan" is necessary to prolong and improve the patient's quality of life, which is why the hepatoprotector is taken throughout his life. Prescribe "Ursosan" for a month, then withstand a break of 60-90 days and repeat the course. Supportive therapy is carried out regularly, observing the indicated time intervals between courses. In the course of treatment, the medication is drunk in 1 capsule in the morning and in the evening.

is a drug from the group

hepatoprotectors

Hepatoprotector Ursosan protects against the harmful effects of the cell

Stabilizing their membranes, improving their functioning and prolonging the period of active work, up to natural death. The protective effect on liver cells is due to the numerous pharmacological effects of Ursosan, which relate to the normalization of the functioning of the organ, improving the outflow of bile, dissolving stones and preventing the formation of new ones. Ursosan removes stagnation of bile in the liver and dissolves cholesterol stones.

Ursosan is used to treat gallstone disease, any type of hepatitis (for example, infectious, alcoholic or toxic), cholestasis, biliary cirrhosis or fibrous degeneration of liver tissue, sclerosing cholangitis, biliary dyskinesia, biliary reflux gastritis and esophagitis, as well as digestive disorders syndrome.

To date, the drug Ursosan is produced exclusively in the form of capsules, which are sometimes mistakenly called tablets. The capsule has a gelatinous opaque shell, painted white. Inside each capsule there is a powdery content, also colored white or almost white. Among the homogeneous and finely dispersed powder, there may be small pieces of white mass. In other cases, the contents of the capsule are a white powder, which is compressed in the form of a column that easily disintegrates with slight pressure.

Ursosan is available and sold in packs of 10, 50 or 100 capsules. The manufacturer of the medicinal product is the pharmaceutical corporation PRO.MED.CS Praha, a.s.

The composition of Ursosan capsules as an active, active ingredient includes ursodeoxycholic acid... Each capsule contains 250 mg of this substance. Today the name "ursodeoxycholic acid" is recommended for use as an international non-proprietary name, but in Russia there is a historical tradition to call this chemical "ursodeoxycholic acid".

Ursosan capsules contain the following substances as auxiliary components:

corn starch magnesium stearate colloidal silicon dioxide titanium dioxide gelatin.

Choleretic action (choleretic).

Anticholestatic (eliminates stagnation of bile in the liver ducts).

Cholelitholytic (destroys cholesterol stones).

Anti-lithogenic (prevents the formation of gallstones).

Hypocholesterolemic action (reduces concentration

cholesterol

Immunodulatory effect (improves

immunity
8.

Antifibrous (prevents the development of fibrous tissue and the formation of

cirrhosis of the liver

From a chemical point of view, ursodeoxycholic acid is a polar substance, that is, it is able to bind various non-polar substances, such as bile acids and cholesterol. Thus, Ursosan binds an excess amount of bile acids, forming micelles, and thereby eliminates their toxic effect on liver cells. The drug forms micelles of the following type - there is bile acid inside, surrounded on the outside by a dense layer of several ursodeoxycholic acid molecules. Such a structure of a complex compound makes it possible to reliably isolate and chemically neutralize aggressive bile acids (chenodeoxycholic, lithocholic, deoxycholic, etc.) so that they do not damage liver cells. This property of Ursosan is used in the treatment of biliary reflux gastritis and reflux esophagitis.

In addition, Ursosan affects the circulation of bile acids, which are secreted into the intestines as part of bile, and then up to 80% is absorbed back into the bloodstream and enters the liver. Ursosan reduces the reabsorption of bile acids in the intestine, thereby stimulating an increase in the synthesis and secretion of bile. Enhanced formation and excretion of bile increases its passage, and also accelerates the release of toxic bile acids by inhibiting their reabsorption into the blood from the intestines. It is these effects of the drug that eliminate stagnation of bile in the hepatic ducts.

Ursosan capsules stabilize the membranes of liver cells, biliary tract and epithelium of the gastrointestinal tract, which protects them from the negative effects of environmental factors. Ursodeoxycholic acid is able to chemically interact with membrane phospholipids, forming complex double molecules. These double molecules, in turn, become structural elements of the cell membrane, which enhance its strength and stabilize it. This property of Ursosan allows you to protect the cells of the liver and biliary tract from the damaging action of free radicals - that is, the drug acts as an organ-specific antioxidant.

Ursosan capsules have a hypocholesterolemic effect, that is, they reduce the concentration of blood cholesterol, by suppressing its synthesis in the liver cells. In addition, the dissolution of cholesterol in bile increases, which significantly reduces its ability to form stones. Due to this effect of the drug, gallstones, formed mainly from cholesterol, are dissolved, and the formation of new ones is also prevented.

Strengthening the immune function under the action of Ursosan is achieved through the following reactions:1. Decrease in the amount of tissue compatibility antigens on the cells of the liver and bile ducts.

2. Normalization of the amount of interleukin-2.
3.

Normalization of T- activity

lymphocytes
4.

Quantity normalization

eosinophils

With cystic fibrosis, liver cirrhosis or alcoholic hepatitis, Ursosan capsules delay the progression of fibrosis. Also, the drug prevents varicose veins of the esophagus.

In addition, Ursosan capsules slow down the aging process of liver cells and biliary tract, preventing a decrease in the functional activity of the organ. Prophylactic use of the drug significantly reduces the rate of progression of colon cancer. Ursosan capsules increase the production of gastric juice and digestive enzymes of the pancreas, reducing the concentration of blood glucose.

Ursosan capsules are used for a wide range of liver diseases, as well as for the prevention of toxic organ damage when working in hazardous industries or taking medications that have a negative effect. The immediate indications for the use of Ursosan capsules are the following conditions:

Gallstone disease, proceeding without complications (capsules are taken in order to dissolve stones in the gallbladder, as well as to prevent their formation after cholecystectomy surgery). Chronic active hepatitis. Acute hepatitis. Chronic and acute viral hepatitis. Chronic opisthorchiasis. Toxic liver damage. including medicinal or alcoholic. Alcoholic liver disease. Non-alcoholic steatohepatitis. Primary biliary cirrhosis of the liver. Primary cholangitis, occurring with sclerosing of the biliary tract. Cystic fibrosis of the liver. Atresia (inadequate development in the intrauterine period) of intrahepatic bile ducts, bile ducts, or reflux. and reflux esophagitis. A digestive disorder associated with biliary dyskinesia and gallbladder pathology. Prevention of a negative effect on the liver of hormonal contraceptives and anticancer drugs.

Ursosan capsules should be taken orally, without chewing, and washed down with a sufficient amount (1/2 - 1 glass)

pure water

The optimal time to take the entire daily dose of Ursosan is evening. The dosage and duration of the course of treatment depend on the type and severity of the pathology. On average, the dosage is calculated from the ratio of 10 mg per 1 kg of body weight. For example, a person weighing 75 kg should receive an average effective dosage of 75 * 10 = 750 mg, which corresponds to three capsules.

For therapy gallstone disease(in order to dissolve stones) Ursosan is taken in a dosage of 2 - 5 capsules daily, for a long period of time. In this case, the duration of the course of treatment is determined by the rate of dissolution of the stones, as well as the development of positive dynamics of the disease. Treatment of gallstone disease with Ursosan capsules can last from several months to several years. It is recommended to take the drug until the stones are completely dissolved, plus another three months in order to prevent the formation of new ones. The entire daily dosage of the drug should be taken once a day - in the evening, before bedtime.

For therapy diffuse liver diseases such as acute and chronic hepatitis, cirrhosis and others, the daily dosage of Ursosan is calculated by the patient's body weight, based on the ratio of 10-15 mg per 1 kg of body weight. For example, with a human body weight of 75 kg, the daily dose of Ursosan for him is 75 * (10 - 15) mg = 750 - 1125 mg, which corresponds to 3 - 5 capsules. Then the calculated daily dosage is divided into 2 - 3 doses per day. The resulting single dose of the drug is taken 2 to 3 times a day with meals. The course of treatment for these liver pathologies is long - from several months to several years. The decision on the duration of treatment is made by the doctor based on the dynamics of the disease and the patient's condition.

For therapy biliary reflux gastritis and reflux esophagitis it is necessary to take Ursosan 1 capsule in the evening, before going to bed. The duration of therapy is determined by the dynamics of the disease and the rate of development of positive changes. The minimum course of therapy is 10 days, and the maximum is 2 years. During this period, Ursosan can be taken without interruption.

For prevention of stone formation after surgery to remove the gallbladder (cholecystectomy), it is necessary to take Ursosan, 1 capsule twice a day, for 3 to 4 months.

For the treatment of liver lesions of toxic, drug or alcoholic genesis, as well as atresia of the biliary tract, the individual daily dosage is calculated by body weight, based on a ratio of 10-15 mg per 1 kg of body weight. For example, with a human body weight of 75 kg, the daily dose of Ursosan for him is 75 * (10 - 15) mg = 750 - 1125 mg, which corresponds to 3 - 5 capsules. The received daily amount of the drug is divided into 2 doses. The single dosage calculated in this way is taken twice a day with meals, for 6 to 12 months.

Therapy primary biliary cirrhosis is carried out by Ursosan in dosages calculated by body weight, based on a ratio of 15 - 20 mg per 1 kg of body weight. For example, with a human body weight of 75 kg, the daily dose of Ursosan for him is 75 * (15 - 20) mg = 1125 - 1500 mg, which corresponds to 4 - 6 capsules. The received daily amount of the drug is divided into 2 - 3 doses. The single dosage calculated in this way is taken 2 - 3 times a day with meals, for six months to several years.

Sclerosing cholangitis requires the use of Ursosan at a dosage of 12-15 mg per 1 kg of body weight per day. The daily dosage, calculated by body weight, is divided by 2 - 3 in order to clarify a single one. Then the calculated single dosage is taken 2 to 3 times a day for a long period of time (from six months to several years). The average single dosage of Ursosan is 2 capsules three times a day.

Therapy non-alcoholic steatohepatitis requires the use of Ursosan in a dosage that is calculated by body weight, based on a ratio of 13-15 mg per 1 kg of body weight. The resulting daily dosage is divided into 2 - 3 doses per day. Treatment requires daily use of the drug for a long period of time - from six months to several years.

Cystic fibrosis requires the use of Ursosan at a dosage of 20-30 mg per 1 kg of body weight. For example, a person weighing 75 kg requires a daily dosage of 75 * (20 - 30) mg = 1500 - 2250 mg, which corresponds to 6 - 9 capsules. The total daily amount of 6 - 9 capsules is divided into 2 - 3 doses per day with meals. Ursosan is taken daily for a long period of time - from six months to several years.

If necessary dissolve cholesterol stones Ursosan can be taken only if the calculi are X-ray negative, their size is no more than 15 - 20 mm in diameter. It is also necessary that the gallbladder performs its function well, and the total number of stones in it should not exceed half the volume of the organs. In addition, for the successful dissolution of gallstones with the help of Ursosan, good patency of the cystic and common ducts is required, through which bile is excreted into the duodenum.

The use of Ursosan capsules for more than 1 month requires regular monitoring of the activity of transaminases (AST, ALAT). Moreover, in the first three months of treatment, enzyme activity is determined once every four weeks. And then the activity of transaminases is monitored once every three months. In addition to a biochemical blood test, while taking Ursosan, a control ultrasound (ultrasound) examination of the biliary tract should be carried out every six months.

After the dissolution of gallstones, it is necessary to prophylactically extend the intake of Ursosan for another 3 months. This measure is necessary to completely dissolve the remains of stones, the size of which does not allow them to be detected by various methods of examination, as well as to prevent the formation of new calculi in the future.

Overdose with Ursosan capsules has not been detected even once for the entire period of use of the drug.

Simultaneous use with aluminum-containing antacids (for example,

AlmagelGastal

etc.) or Cholestyramine reduces the effectiveness of Ursosan.

The simultaneous use of Ursosan with the following drugs reduces its activity in dissolving gallstones:

Clofibrate; estrogens (eg Estradiol, Estriol, etc.); Neomycin; progestins (eg Desogestrel, Dydrogesterone, Levonorgesterl, Linestrenol, Megestrol, Medroxyprogesterone, etc.).

Ursosan during pregnancy

The use of Ursosan during pregnancy and lactation is possible in situations where the benefits of the drug will outweigh the possible risks. This position is based on the fact that large-scale and full-fledged trials of the drug on pregnant women have not been carried out for obvious ethical reasons. However, according to experimental data obtained in animal studies, no negative effects of Ursosan on the fetus were detected.

German researchers conducted limited clinical trials of Ursosan, during which the drug was taken by pregnant women with severe liver and biliary tract disorders. This group of pregnant women needed Ursosan for health reasons. As a result of the study, there was no negative impact on the child's condition. Due to this circumstance, practitioners in Germany and France have come to the conclusion that Ursosan can be used during pregnancy to treat the following common conditions:

Violation of the outflow of bile due to compression of the gallbladder increasing

uterus
2.

Chronic pathologies of the gallbladder in the stage of exacerbation (for example, colic against the background of movement of stones).

3. Itching

pregnant women due to impaired bile secretion.

Chronic liver pathologies, accompanied by a deterioration in well-being and an increase in the activity of AST, ALT, bilirubin and other laboratory tests.

Very often, pregnant women are faced with excruciating itching, which is associated with the fact that the uterus compresses the gallbladder and interferes with the outflow of bile. Stagnation of bile, in turn, leads to the active excretion of bile acids through the skin, which is accompanied by unbearable itching. This condition can be observed in perfectly healthy pregnant women or in women suffering from various pathologies of the liver and biliary tract. Ursosan in such situations effectively eliminates itching of pregnant women. Usually you need to take 1 - 2 capsules in the evening, with meals, daily for 1 month. If necessary, the course of taking Ursosan can be extended until delivery. Pregnant women should remember that itching is a functional reflection of the stress on the liver and gallbladder. But itching does not have a negative effect on the child's condition.

Ursosan is also effective for the treatment of attacks of gallstone disease, as well as for maintaining the functional state of the liver in chronic hepatitis in pregnant women. In such situations, Ursosan must be taken 2 capsules twice a day, for a month. If the condition has not returned to normal, then taking the drug can be extended until delivery.

Ursosan for newborns - instructions for use

newborn

the child can develop

Which is a physiological condition. Physiological jaundice is considered, which lasts no longer than three weeks. If after three weeks the jaundice does not decrease, then we are talking about a pathological condition. If the jaundice gradually decreases, but by the first month after birth it has not completely disappeared, then this is a variant of the norm. Gradual normalization of skin color is allowed up to 4 months. In these situations, neonatologists recommend not taking any

medicines

Jaundice in newborns is caused by the breakdown of large amounts of hemoglobin, which the liver is unable to quickly remove. However, with very severe jaundice, when the bilirubin content is high, damage to the central nervous system is possible. In such situations, it is necessary to reduce the concentration of bilirubin by medication. To eliminate such severe and dangerous jaundice, doctors recommend giving the child Ursosan. The drug is taken 2 - 4 weeks in a row, a quarter of the capsule daily. Doctors recommend pouring the contents of the capsule onto a saucer, dividing it into 4 equal parts and giving it to the child by dissolving it in water or breast milk.

With good, positive dynamics (that is, if the jaundice disappears quickly), you can reduce the course of treatment to 10 days. Every week while taking Ursosan, the concentration of bilirubin in the blood should be monitored. On average, a weekly intake of Ursosan provides a decrease in the concentration of bilirubin by 50 units. After reaching the concentration of bilirubin in the blood equal to 100 mg / ml, the drug can be canceled.

Ursosan can be used to treat various diseases of the liver and biliary tract in children from 2 years of age. In this case, the dosage is calculated for each child individually, depending on body weight, based on a ratio of 10 - 20 mg per 1 kg of body weight. In this case, the child should be given the entire daily dosage in the evening, with meals.

If a child cannot swallow a large enough capsule whole, pour the contents into water and dissolve. Then give the child Ursosan to drink in the form of a solution. In this case, you should make sure that the child drinks the entire solution. Children aged 2 to 4 years may have difficulty swallowing capsules, so it is necessary to control the moment of taking the drug.

Children generally tolerate this drug well. Ursosan helps in the treatment of acute childhood hepatitis, as well as various disorders of the outflow of bile (for example, with atresia of the bile ducts). Also, Ursosan will help to cope with various digestive disorders in children that arise from the abuse of fatty or fried foods.

C is a serious medical condition that significantly increases the risk of liver cancer. In addition, with a prolonged course of hepatitis C, the liver degenerates, as a result of which normal cellular structures are replaced by fibrous tissue. After a while, liver fibrosis leads to a formidable disease - liver cirrhosis. Ursosan hinders development

And also significantly reduces the rate of formation of liver cirrhosis. In this case, Ursosan can be considered as a drug that is necessary to prolong the life of a person suffering from hepatitis C.

With hepatitis C, Ursosan is taken for the rest of his life in courses several times a year. Usually a course of 1 month is prescribed, then you need to take a break for 2 - 3 months. Thus, it is necessary to constantly undergo courses of therapy at the indicated intervals between them. During treatment, the drug is taken 2 capsules twice a day with meals or immediately after a meal with a glass of clean water.

Starting to take Ursosan for hepatitis C, it should be remembered that this drug does not cure liver pathology, but prevents the development of fibrosis and cirrhosis. To date, the treatment of hepatitis C is exclusively antiviral therapy, which is carried out with potent interferon drugs. And Ursosan helps to maintain a good functional state of the liver and effectively cleanse the organ of toxic substances.

Ursosan capsules are usually well tolerated by patients, but they have few side effects. Most often, Ursosan causes side effects related to the organs of the digestive tract, such as:

nausea; vomiting; diarrhea; constipation; periodic increase in the activity of hepatic transaminases (ALT, AST); calcification of gallstones; abdominal pain. Moreover, the development of diarrhea against the background of Ursosan may depend on the dosage. That is, when taking 3 capsules, a person may develop diarrhea, and when using a lower dosage - only 1 or 2 capsules, this digestive upset will not occur. Therefore, when diarrhea appears while taking Ursosan, the total daily dosage should be slightly reduced.

In addition to side effects on the digestive tract, Ursosan can cause undesirable effects from other organs and systems, such as:

back pain; allergic reactions; itching of the skin; baldness.

In the presence of absolute contraindications, Ursosan should not be taken in any case. The following conditions are absolute contraindications:

X-ray positive structure of gallstones (that is, high calcium content in calculi); low functional activity of the gallbladder; gall-gastrointestinal fistula; acute cholecystitis; acute cholangitis; cirrhosis in the stage of decompensation; liver failure; renal failure; blockage of the biliary tract; acute diseases gallbladder and bile ducts of an infectious nature; empyema of the gallbladder; sensitivity, allergy or intolerance to the components of Ursosan.

In the Russian pharmaceutical market, the following drugs are synonymous with Ursosan:

Livodexa - tablets in a film shell; Urdoksa - capsules; Ursodeoxycholic acid - capsules; Ursodex - tablets in a film shell; Ursoliv - capsules; Ursorom Rompharm - capsules; Ursofalk - capsules and suspension; Urso 100 - capsules; Ursodezom - capsules capsules; Choludexan - capsules; Exhol - capsules.

The following drugs are analogous to Ursosan capsules:

Allochol - tablets; Cholenzim - tablets.

In addition, many people take Ursosan after dietary errors, alcohol and smoking abuse, or after antibiotic therapy, since the drug helps to quickly and effectively normalize the gallbladder, and eliminate heaviness and pain in the right hypochondrium. People suffering from chronic cholecystitis, as well as digestive disorders after removal of the gallbladder, note that Ursosan perfectly relieves pain and discomfort when dieting, eating fatty, fried, alcohol, etc.

People suffering from hepatitis also note the positive effect of Ursosan, which is expressed in improving overall well-being. If we are talking about acute hepatitis, then people also note the acceleration of recovery, as well as the rapid convergence of jaundice and the normalization of the color of the skin.

The excellent effect of Ursosan as a prophylactic agent for maintaining the functional activity of the liver is also noted by people who do not suffer from various diseases of the gallbladder or hepatitis. As a rule, this category of people takes Ursosan courses after various table events, during which they abuse fatty and fried foods, as well as alcoholic beverages.

Separately, it is worth noting the reviews of parents, in whose newborn children Ursosan helped to eliminate neonatal jaundice. This category of people notes that, against the background of the use of hepatoprotector, the jaundice of newborns disappeared very quickly, and the child's skin acquired a normal color.

Despite the overwhelming majority of positive reviews about Ursosan, there are also some negative statements. As a rule, these negative reviews are associated with the fact that the gallstones could not be dissolved, and the gallbladder had to be removed surgically. In such situations, people hoped that it would be possible without surgery, but even a long course of Ursosan could not defeat the disease formed by long years of improper lifestyle. As a result, people feel frustrated and give negative feedback on the drug.

Urdoksa is a home-made Ursosan generic. This means that after the expiration of the patent, any pharmaceutical company can use the prescription of the drug and make its own medicine based on the data on the composition given in any instructions for use. However, as a rule, ready-made components are taken for the preparation of a generic drug, which are being obtained by various laboratories. Therefore, the purity and potency of the active ingredient in the original preparation and the generic can differ significantly.

However, in the situation with Urdoksa, the situation is somewhat different from the usual one. The fact is that the domestic pharmaceutical corporation that manufactures the drug purchases all the necessary components abroad. That is, all active and auxiliary substances in Urdoks are exactly the same as in Ursosan. The only difference between the drugs is that Ursosan is produced in factories in Germany and the Czech Republic, while Urdoksa is produced in Russia. That is why there is no difference between the drugs, except for the price (Urdoks is much cheaper). You can choose the drug that you subjectively like more.

More about the drug Urdoks

There are also various subjective reviews about the effectiveness of Ursosan and Ursoliv. In some people, the stones dissolved under the influence of Ursosan, while for others the drug did not help at all. But Ursoliv, on the contrary, dissolved the stones. Thus, Ursoliv and Ursosan can have a different effect in terms of effectiveness, depending on the individual characteristics of each organism. In this case, there are no objective signs by which it is possible to determine who is better suited for Ursosan, and for whom - Ursoliv. Therefore, it is necessary to try both drugs and choose the most effective one based on subjective feelings.

However, do not forget about the individual characteristics of the organism. While Ursofalk is better suited for most people, there is a smaller group that Ursosan is more suited to. Therefore, we can recommend that you first try to undergo a course of treatment with Ursofalk, and if the result does not suit the person, then go to Ursosan. And thus, choose the best drug for yourself.