One of the achievements of the modern pharmaceutical industry is the Lyoton gel for external use. It is a viscous mass with a delicate aroma of medicinal resins.
Application features
Release form
It may be colorless or somewhat yellowish. Excellent pharmacological properties and the practical absence of side effects allow the gel to be widely used in a variety of conditions and for venous disease at different stages of development.
Excellent indicators of preventing blood clotting make it possible to use Lioton as a therapeutic and prophylactic agent.
Composition
Lioton - Lioton is offered as an ointment or gel for external use only. One gram contains 1000 IU of sodium heparin and auxiliary agents:
- Carbomer 940;
- 96% ethanol;
- Methyl parahydroxybenzoate;
- Propyl parahydroxybenzoate;
- Triethanolamine;
- Lavender and neroli oil;
- Water.
Lyoton price 1000
Lyoton is produced - a gel in tubes of highly purified aluminum of various weights from 30 to 100 grams. The price varies in various pharmacy chains from 325 - a small tube to 490 rubles - packaging 100 gr.
Pharmacological features
Ointment for external use is an antithrombotic drug for external use.
- It allows you to significantly improve interstitial exchange,
- Intensifies the processes of blood microcirculation,
- Decreases
- The resorption of blood clots is activated and the change in the structure of the blood is accelerated.
Indications
The indications are pathologies of the vascular bed:
- internal and subcutaneous hematomas,
- thrombophlebitis of external veins,
- phlebothrombosis of a different nature,
- with complications in the postoperative period,
- mastitis,
- local edema,
- (with caution, may cause),
- bruises
- violations of the integrity of joints, muscles, tendons.
The gel allows for active therapy after invasive and after injection phlebitis, prevention of thrombophlebitis.
Contraindications
- The drug is contraindicated in people who have hypersensitivity to and its components.
- Doctors do not recommend applying the gel to the mucous membrane, the surface of open wounds, during bleeding, and necrotic diseases.
- It is strictly forbidden to apply the gel against a background of high bleeding and thrombocytopenia.
Instructions for use
- The ointment is applied to the affected area in thin lines, no more than 10 cm in length. The course of treatment is up to 20 - 25 days three or four times a day.
- If the patient is diagnosed with thrombophlebitis of the hemorrhoidal venous bed, the gel is applied to the anus with a tampon.
- The drug is indicated for use in newborns, in pediatrics, during pregnancy and lactation, it does not interact with other drugs.
- Overdose phenomena have not been registered.
This video provides instructions on how to use the Lyoton 1000:
Side effects
Rarely, but there are:
- , sometimes diarrhea.
- thrombocytopenia followed by arterial thrombosis accompanied by gangrene.
- irritation, hematoma.
special instructions
- Contraindications in some cases are allergic reactions and individual intolerance to the components of the gel.
- Special factors are the possibility of a reaction to the presence of alcohol or drugs in the body, the gel can cause a local reaction in the form of edema or
Gel Lioton 1000 is intended for the treatment of bruises, bruises and sprains of tendons and ligaments. The medicine is based on heparin sodium salt 1000ME. This explains the numbers in the name of the medicine. They also indicate the amount of substance in one gram of the drug.
The viscous gel can have a yellowish tint or be completely transparent and is intended for external use. The package is a cardboard box with one tube of gel weighing 25 grams.
Application of Lioton gel
Gel Lioton 1000 is used to treat:
- bruises;
- hematomas;
- other damage to soft tissues;
- sprains of ligaments and tendons;
- phlebothrombosis;
- thrombophlebitis of superficial veins;
- when eliminating complications after these diseases.
Also, the remedy is used for soft tissue edema and localization of infiltrates.
Including gel Lyoton has indications for use with. During illness and in the postoperative period, ointments that contain heparin are used. In this case, Lyoton perfectly copes with its task - it stimulates regeneration processes. This drug is the most effective, since the content of heparin is sufficient for quality treatment - 1000 IU per gram. This is several times more than similar medicines, which are less effective.
To treat bruises, the gel is applied to the skin with a strip of three to ten centimeters and rubbed into it. The procedure must be done three times a day.
Gel Lioton is often used for the face, but this must be done carefully so that it does not get into the eyes and lips, and later into the digestion. It is also worth bypassing the area around the eyes, as this can cause rarefaction of the mucous membrane and skin in these areas.
For rectal application of ointment (treatment of thrombosis of hemorrhoidal veins), a cotton swab soaked in ointment is used. It must be inserted into the anus or applied to the restrained nodes. The treatment takes place over a short period of three to four days. In this case, many are afraid of an overdose of the medication, since the gel has contact with damaged tissues. But Lyoton is insignificantly absorbed into the blood, so an overdose of medication is almost impossible.
Gel composition Lioton 1000
The main active ingredient in the composition of the medicine is heparin sodium salt 1000ME. Excipients are:
- methyl larahydroxybenzoate;
- propyl larahydroxybenzoate;
- carbomer 940;
- ethyl alcohol 96%;
- neroli oil;
- lavender oil;
- triethanolamine;
- purified water.
Lioton 1000 is intended exclusively for external use and is a transparent, colorless, viscous gel with a mild, mild odor. Manufacturers brought 50 and 30 gram tubes to the pharmaceutical market.
The main component of the drug is sodium heparin, and each gram of gel contains 1000 units of this component. Neroli and lavender essential oils were used to give the preparation a pleasant scent.
Berlin Chemie developed Lyoton as an anticoagulant drug, for this reason and made heparin sodium an important component. Heparin prevents blood clots and can be found in the kidneys in the human body.
When it enters the bloodstream through intravenous administration or when applied to the skin, the heparin molecule provokes the protein to activate its properties and counteract clotting. It also prevents the formation of blood clots.
Heparin, which is in Lyoton gel, has the ability to enter the bloodstream gradually and enter the systemic circulation, while the following happens:
- increased blood flow in the kidneys;
- vascular resistance increases significantly;
- the possibility of blood clots and myocardial infarction is minimized;
- the growths on the skin are absorbed.
With all the influence of the main component on the body, the drug has no effect on blood clotting.
Pharmacokinetics
After external application, the maximum concentration in the blood plasma is observed after 8 hours, and for another whole day heparin is found in the body at a level equal to the therapeutic one. The excretion of the main and auxiliary components (unchanged metabolites) occurs with the help of the kidneys. When applied externally, Lyoton 1000 does not affect the hemocoagulation process itself and its parameters.
Indications
This drug is used primarily for the complex treatment of pathologies of superficial veins. These include:
- phlebothrombosis (a disease characterized by the development of a thrombus that completely or partially closes the lumen of the vessel);
- thrombophlebitis (a pathology in which the vessel wall becomes inflamed and its lumen overlaps);
- superficial periphlebitis (inflammatory process of the vascular wall in acute or chronic course).
Also, doctors believe that it is very good to use Lyoton 1000 Ointment after surgical intervention on the veins, muscle and ligament sprains, soft tissue injuries, which are accompanied by bruises and swelling.
Contraindications
Despite the fact that the drug contains a fairly simple component, there are a number of contraindications for its use. Let's consider the main ones:
- allergy to the main or auxiliary components of the drug;
- ulcers and necrotic lesions of the epidermis in the places of intended use of the drug;
- decreased hemocoagulation;
- thrombocytopenia.
Side effects
Clinical studies have shown that Lyoton gel causes a minimum number of negative reactions, which its counterparts cannot boast of. Patients only reported allergies that manifested themselves on the skin.
Instructions
The instructions for use indicate that Lyoton 1000 is used by adult patients in a dose equal to 3-10 centimeters of gel, which depends on the area of the lesion. After application, it is necessary to rub in the drug with gentle massage movements until it is completely absorbed. You can carry out the procedure no more than three times a day. The course of therapy directly depends on the degree of damage and the severity of the disease.
Overdose
To date, no information has been received about an overdose. This is due to the fact that sodium heparin, when applied externally, is absorbed systemically only in a small amount.
If a child accidentally swallows the gel, then in most cases nausea and vomiting occurs. First aid consists in gastric lavage and symptomatic treatment. Protamine sulfate is an antidote for sodium heparin poisoning.
Drug interactions
Since Lyoton gel is very rarely used in monotherapy, it is worth considering possible drug interactions:
- The prothrombin time is lengthened when using Lioton gel 1000 with other drugs of the anticoagulant group.
- It is forbidden to apply several medicines for external use at the same time.
- It is not recommended to apply Lioton gel when taking non-steroidal anti-inflammatory drugs, tetracycline antibiotics and antiallergic drugs.
Application features
Since methyl and propyl p-hydroxybenzoate was introduced into Lyoton as an adjuvant, the drug should not be used by patients with a history of paraben allergy.
If you have hemorrhagic symptoms, you should weigh all the possible risks before using this medication. There are also a number of prohibitions that must be taken into account when treating the underlying disease with the Lyoton 1000. These include:
- infected surface of the epidermis.
You should be careful and prevent contact with the eyes and mucous membranes of the mouth and nose. Violation of hemocoagulation requires the use of the gel on not extensive areas, and with phlebitis, rubbing Lyoton into the skin is prohibited.
In pediatrics
The experience of prescribing and using the drug for young patients is limited, for this reason it is worth refraining from applying the gel to children.
Influence on reaction
Clinical studies have shown that the agent has no properties to affect the reaction rate, slow down the patient's activity and can be used while driving a car or working with other mechanisms.
During pregnancy
It is possible to apply Lyoton while carrying a baby and breastfeeding only if there are strict indications. Most often, this category of patients uses the drug according to the scheme: a month is applied to the skin, and a break is taken for 30 days. In the first trimester of pregnancy, you should be as careful as possible while using the drug, since the risk of developing allergic reactions is very high. If any kind of redness, itching, burning occurs, you must immediately stop using Lyoton and report the incident to your doctor.
Acquisition
You can buy Lyoton without much difficulty at any pharmacy. To purchase it, there is no need to go to a doctor to write a prescription.
Lioton 1000 gel does not require special storage conditions, it is enough not to exceed the temperature of 25 degrees and protect the drug from the access of children.
The shelf life of the drug is indicated on the package and it is 5 years from the date of release. After the expiration of this period, the use of the drug is prohibited.
Analogs
The drug Lioton has a large number of analogues both in terms of the active substance and the mechanism of action. Let's consider the main ones:
- Heparin ointment;
- Venolife;
- Hepatrombin;
- Heparoid;
- Venitan Forte;
- Dolobene;
- Hepariod and many others.
What's better
Many pharmacy buyers are interested in which is better: Heparin ointment or Lyoton. Let's try to answer this question. These drugs have a lot in common:
- refer to direct anticoagulants;
- the mechanism of action is to suppress thrombin.
In addition, the main difference between these drugs is the quantitative content of the main component in 1 gram of the drug. In Heparin ointment there are only 100 units of sodium heparin, and in Lyoton - 1000 units. Patients note that with regular use, there is no significant difference in the effects, and therefore they often buy Heparin Ointment, since it is much cheaper than its competitor.
Lyoton contains as an active substance sodium heparin at a concentration of 1000 IU / gram.
The gel contains as auxiliary components: methyl and propyl p-hydroxybenzoate, neroli and lavender oils, carbomer 940, triethanolamine, ethanol, purified water.
Release form
The dosage form of the drug is a gel for external use. The product is an almost transparent, colorless or slightly yellowish, viscous mass.
The Lioton 1000 gel goes on sale in aluminum tubes with a volume of 30, 50 or 100 grams.
pharmachologic effect
Antithrombotic , anti-exudative , moderate anti-inflammatory .
Pharmacodynamics and pharmacokinetics
When applied to the skin, Lyoton gel relieves puffiness, eliminates the increased permeability of the vascular walls and prevents the release of fluid (exudate) into the adjacent tissues, suppresses the inflammatory process, inhibits the activity of the blood coagulation system (has an anticoagulant anticoagulant effect).
After using the drug is found in over the next 24 hours, while the plasma concentration reaches its maximum values after 8 hours.
Excretion of the substance and its metabolites carried out mainly kidneys ... When applied to the skin heparin does not affect the parameters hemocoagulation .
Indications for use
Lioton 1000 ointment is recommended for use in case of diseases superficial veins , including complicated phlebothrombosis (a condition associated with the formation in the lumen of a vein fixed to its wall thrombus , partially or completely obstructing the vessel), (which is accompanied by inflammation of the vascular wall and overlap of the lumen of the vessel thrombus ) or superficial periphlebitis (acute or chronic inflammation of the vein wall).
It is considered advisable to use Lyoton ointment to eliminate complications provoked by a surgical operation on veins , consequences of injuries and sprains capsular-ligamentous and muscle-tendon apparatus , damage soft tissues and musculoskeletal system .
The tool effectively removes localized tissue edema , eliminates inflammatory infiltrate, accelerates the resorption of subcutaneous hematomas .
Contraindications
Do not use Lioton 1000 cream when:
- known individual sensitivity to its components;
- stock ulcerative and necrotic changes in the skin in the areas of the intended application of the product;
- traumatic violations of the integrity of the skin;
- lowered;
- thrombocytopenia .
Side effects
Allergic reactions.
Gel Lioton, instructions for use
The instructions for use of Lyoton indicate that a single dose for an adult corresponds to the volume of gel contained in a strip with a length of 3 to 10 cm (depending on the extent of the lesion). After applying to the skin, the ointment should be gently rubbed in with light movements.
Frequency rate of applications - from 1 to 3 times a day.
According to the instructions for the Lyoton 1000, the duration of treatment depends on the indications and the severity of the pathological process.
Overdose
To date, there have been no reports of overdose cases. Since systemic absorption heparin sodium extremely negligible, there is no danger of an overdose of the drug when applied topically.
If the gel is accidentally swallowed, the child may experience nausea and vomiting. To help the victim, the stomach should be flushed and, if necessary, symptomatic treatment should be prescribed.
The antidote is protamine sulfate .
Interaction
Application heparin in combination with oral anticoagulants, it can cause prolongation of prothrombin time.
You should not mix Lyoton with other drugs for external use.
It is contraindicated to prescribe the drug in combination with NSAIDs, antibiotics of the tetracycline series , antihistamines .
Terms of sale
Over the counter.
Storage conditions
Shelf life
The product is considered usable for 5 years after the date of issue.
special instructions
As auxiliary components, the gel contains methyl and propyl p-hydroxybenzoate, therefore Lyoton is contraindicated for persons with known parabens .
In patients with hemorrhagic symptoms should carefully weigh the appropriateness of the use of funds.
The drug should not be used for bleeding and skin lesions by a purulent process, applied to infected skin areas and open wounds, mucous membranes, skin around the eyes. You should also avoid getting the gel in your eyes.
Patients with disabilities hemocoagulation it is not recommended to treat large areas of the skin with the drug. When treating phlebitis , it is contraindicated to rub the ointment into the skin.
Since the experience of using Lyoton in children is limited, the drug should not be prescribed for the treatment of this category of patients.
The tool does not affect the ability to drive vehicles and does not slow down mental and motor activity.
Analogs Lioton 1000
Matching ATX level 4 code:The group of drugs that are similar in their mechanism of action include: Forte , Venabos , Trombless Plus , .
Russian analogues of Lyoton: Heparin , Heparin-Akrigel , Heparin ointment .
The price of analogs is from 35 Russian rubles (the purchase of a 25 g tube of Heparin ointment produced by the Russian company Biosintez OJSC will cost about 35-60 rubles).
Lyoton or Heparin Ointment?
Gel and its analog Heparin ointment Are straight anticoagulants ... The main mechanism of their antithrombotic action associated with suppression thrombin .
Sodium salt heparin , which is the active component of Lyoton, in the composition Heparin ointment present in a lower concentration - 100 IU / gram (in Lyoton, its concentration in one gram of the agent is 1000 IU). However, apart from heparin sodium v Heparin ointment also contains (local anesthetic broad spectrum of action) and antiplatelet benzyl nicotinate .
Evaluating the effectiveness of both drugs, patients note that the effect of their use is approximately the same, therefore, for many, when choosing a drug, the price becomes a decisive factor - Heparin ointment an order of magnitude cheaper than its counterpart.
Lyoton during pregnancy
Gel Lioton during pregnancy and during breastfeeding (lactation) is allowed to be used only on strict indications.
Usually, pregnant women are prescribed to use the drug throughout the entire period of pregnancy (and sometimes after the birth of a child) in courses according to the scheme: a month of use, a month off.
Care should be taken with the first application of the product, since during pregnancy the body becomes more susceptible to allergens , and the probability of occurrence allergic reactions increases.
Therefore, if the treatment is accompanied by such unpleasant symptoms as itching, redness of the skin, burning, etc., you should stop using the drug and consult a doctor.
As for the reviews about the use of Lyoton by pregnant women, they are very diverse. Someone did not see the result even after several months of treatment, someone, on the contrary, notes the high efficiency of the drug.
Lyoton 1000 reviews
Reviews of Lioton 1000 gel are mostly positive, as can be judged by the rather high assessment of the product on specialized Internet resources - 4-4.5 points out of 5.
Due to the high concentration heparin the ointment prevents the appearance spider veins , relieves heaviness in the legs, eliminates swelling and soreness, is effective for bruises and sprains. Many women see the drug as practically the only salvation for tired legs after a day on their feet (and often in high heels).
Very often, the remedy is prescribed to pregnant women, since during the period of bearing a child, the likelihood of problems associated with it increases significantly.
During pregnancy - the reviews are an eloquent confirmation of this - Lyoton effectively fights stagnation venous blood , prevents the occurrence thrombophlebitis and severe edema, improves the tone of the vascular walls, relieves fatigue.
Negative reviews about the gel are due to the fact that after a sufficiently long use of this drug, the patients were never able to cure varicose veins or notice clear improvements in leg conditions.
Commenting on such statements, experts do not get tired of repeating that Lyoton does not heal, but only is a supportive agent, the use of which can slow down the progression of the pathological process and prevent the development of its complications.
To make the effect of using the cream noticeable, the treatment should be supplemented by wearing compression hosiery, a contrast shower for the legs, swimming, and hiking.
It is equally important to stop crossing your legs, instill in yourself the habit of regularly resting your legs (at least trying to keep them in an elevated position more often), and preferring comfortable shoes.
On the Internet, there are also often positive reviews about Lyoton when used for the face. Despite the fact that the main indications for use are venous diseases, the range of application of the drug is much wider.
For the face, the gel is indicated as a decongestant, tightening, toning and refreshing agent. Some women even use it as a base for makeup, and plastic surgeons and cosmetologists often recommend an ointment to normalize the condition of the facial skin after a series of beauty procedures or, for example, blepharoplasty.
Gel price Lioton 1000
The price of Lioton 1000 in Ukraine
The price of Lioton gel in Kharkov, Kiev and other large cities of Ukraine differs slightly.
The price of the ointment produced in tubes of 30 g - from 90 UAH. You can buy a tube of cream 50 g for an average of 160 UAH.
How much does the gel cost in Russian pharmacies?
The cost of the drug depends on the volume of the tube. Buying a tube with a volume of 30 g will cost about 350 rubles. The average price of Lyoton in tubes of 50 g is 450 rubles, in tubes of 100 g - 700 rubles.
Lioton 1000 is a gel designed to eliminate signs of diseases, accompanied by the formation of blood clots, increased blood viscosity. The drug is also characterized by other properties, but the degree of their manifestations is somewhat lower. The tool is intended for the treatment of external integuments. However, it is important to apply the gel in accordance with the manufacturer's recommendations, as the effectiveness of the drug may decrease if weeping is not eliminated.
Release form and composition
Lyoton represents a group of one-component products. Contains a substance that is universal due to its properties - heparin sodium salt. Other components in the composition do not have an antithrombotic effect. The preparation is characterized by a gel-like structure. The concentration of the main component in 1 g of the drug substance is 1000 IU / g. Additionally, the composition includes other compounds:
- methyl parahydroxybenzoate;
- ethanol;
- propyl parahydroxybenzoate;
- carbomer;
- neroli and lavender oil;
- triethanolamine;
- purified water.
The gel is transparent, may have a yellowish tint. The drug can be purchased in tubes (30, 50 and 100 g).
Pharmacological action of Lioton 1000
Heparin sodium is an anticoagulant substance. Included in the group of direct action means.
This means that the substance directly affects the formed elements of the blood, which is its advantage over the analogs of indirect action, which affect the process of blood coagulation through the liver (suppress the synthesis of prothrombin in the organ). As a result, the positive effect of using heparin is provided much faster.
The active ingredient in Lyoton 1000 is produced by mast cells (basophilic granulocytes of connective tissue). Represents a group of glycosaminoglycans.
The main function of the drug is realized due to the ability to bind to antithrombin III. Due to this, changes occur in the structure of the molecule of this blood corpuscular element, which leads to a more intense binding with the serine proteases of the coagulation system. The result of this process is blocking the activity of thrombin and a number of activated factors: IX, X, XI, XII, as well as kallikrein, plasmin.
The anticoagulant property of heparin is provided due to some similarity of its molecule and antithrombin III. The acceleration of the process of inhibition of thrombin occurs due to the combination of the active substance of the drug with the gamma-aminolysyl parts of antithrombin III. A decrease in the intensity of the thrombin release process is due to the interaction of serine in its composition and arginine (formed by the complexation of heparin and antithrombin III).
The main advantage of the active ingredient in the composition of the drug is the ability to leave the heparin-antithrombin III compound. After that, it becomes possible to reuse it by the body.
The remaining constituent elements of the heparin-antithrombin III complex are utilized by the endothelial system.
Under the influence of heparin, due to the processes described above, there is a decrease in blood viscosity along the entire length of the venous bed, which, against the background of a decrease in the permeability of the vessel walls, provides a positive effect: the intensity of puffiness decreases, the risk of stagnation is excluded, since blood does not penetrate beyond the superficial veins.
Another property of heparin is the ability to linger on the membranes of endothelial cells and other blood cells. This increases their negative charge. As a result, platelets lose their ability to linger on the walls of blood vessels, particles of blood corpuscles cease to combine with each other. Thanks to this, the process of blood clots formation is inhibited.
In addition to the decongestant, anticoagulant properties, the ability of heparin to inhibit the synthesis of immunoglobulins and antihistamine is noted. As a result, the substance has an anti-allergic effect. Another property is the moderate suppression of the inflammatory process. Heparin is also involved in the work of the endocrine system. The greatest efficiency of this substance is noted when suppressing excessive synthesis of the hormone aldosterone in the adrenal cortex.
The active ingredient in a small amount penetrates into the blood. The peak efficacy of sodium heparin is reached 8 hours after application to the external integument.
The concentration of the main substance in the plasma gradually decreases. Heparin is excreted from the body no later than 1 day later. The kidneys are involved in this process. The active substance is excreted during urination.
Indications for use of Lioton 1000
Given that the components of the drug penetrate into the blood only slightly, the agent in question is inappropriate to use for deep vein diseases.
Indications for use:
- thrombophlebitis and superficial vein thrombosis;
- recovery period after surgery, but only with developing complications in the veins;
- prevention of severe pathologies at the first signs of violations of the hematopoietic system (the drug helps to get rid of fatigue in the legs, edema);
- inflammation of hemorrhoids, but the gel is intended for external use, which means that it is recommended to use it when external formations appear in the perianal region;
- bruises, hematomas resulting from injuries, bruises;
- constant, which is a consequence of the accumulation of infiltrate in the tissue structure;
- inflammatory processes in the joints, tendon sprains.
Contraindications
Lyoton is not prescribed in a number of cases:
- intolerance to the main component of the drug;
- trauma to the skin;
- bleeding;
- developing ulcerative formations, purulent processes with the manifestation of symptoms on the outer integument;
- tissue necrosis;
- pathological conditions in violation of the hematopoietic system, for example, thrombocytopenia;
- bleeding tendency.
It is not recommended to use a heparin-based drug for the treatment of mucous membranes. At the same time, the intensity of absorption of the drug increases, which can lead to an increase in negative manifestations.
Dosing regimen of Lioton 1000
The medicine is rubbed in a circular motion, and there is no need to press on the skin.
Frequency of application of the product: 1-3 times a day. The duration of treatment is determined by the doctor, however, in most cases, it is recommended to use Lioton for 3-7 days.
When the symptoms disappear slowly, it is permissible to use the drug until the unpleasant symptoms are eliminated.
Side effects
Adverse reactions are infrequent. In most cases, Lyoton therapy is well tolerated, however, some patients develop an allergy to the components in the composition of the drug, hyperemia.
Overdose
There is no information about cases when negative reactions developed against the background of an increase in the recommended dose.
However, when using the gel inside, children may experience the following symptoms: nausea, vomiting.
The stomach should be flushed, otherwise the active component is absorbed by the walls of the gastrointestinal tract, which will lead to disruption of the hematopoietic system. If symptoms persist, symptomatic treatment is prescribed. The substance protamine sulfate neutralizes the effect of heparin.
The low likelihood of an overdose when processing the outer covers is due to the poor absorption of the active component into the blood. However, when the substance is applied to the mucous membranes, the amount of heparin in the plasma increases.
special instructions
It is not recommended to use the drug for bleeding, in this case, the properties of heparin are enhanced, since this substance prevents the cessation of blood flow, having a direct effect on the formed elements in its composition. Avoid getting heparin on open wounds, as well as in cases where exudate is released, necrotic, purulent processes develop.
Application during pregnancy and lactation
The drug can be used in such conditions of a woman, but it is prescribed in cases where the positive effects outweigh the potential harm. It is necessary to exclude all risk factors under the influence of which bleeding may develop (treatment of open wounds, application of gel to mucous membranes).
Application in children
Given that there is no information on the positive or negative effects of the drug on the body of patients under 18 years of age, it is not recommended to prescribe it in this case.
Drug interactions
Lyoton 1000 is not used together with other external products. It is forbidden to combine this drug with drugs of the NSAID group, tetracyclines. Given that the agent in question exhibits not only anticoagulant, anti-inflammatory properties, but also helps to stop the development of an allergic reaction, it should not be used simultaneously along with antihistamines.
Terms and conditions of storage
Acceptable ambient temperature for drug storage is up to + 25 ° C.
Conditions of dispensing from pharmacies
You can buy the product without a prescription.
Price
Lyoton 1000 is offered at a price of 370-715 rubles. The cost varies depending on the volume of the tube.
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Lioton 1000, instructions for use. Injuries and bruises, infiltrates and localized edema
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