In this medical article, you can read the drug Nystatin. The instructions for use will explain in which cases it is possible to take suppositories, ointments or tablets, from which the medicine helps, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.
In the article, doctors and consumers can leave only real reviews about Nystatin, from which it is possible to find out whether the medicine helped in the treatment of thrush and candidiasis in adults and children, for which it is also prescribed. The instructions list Nystatin analogues, drug prices in pharmacies, as well as its use during pregnancy.
The drug Nystatin instructions for use are classified as antifungal antibacterial agents. Tablets and suppositories (vaginal and rectal) 250 thousand units and 500 thousand units, ointment is used for the treatment of infectious fungal pathology caused by pathogens sensitive to the active substance of the drug.
Release form and composition
Nystatin is available in the following dosage forms:
- Vaginal suppositories 250,000 IU and 500,000 IU.
- Ointment for external use.
- Coated tablets 250,000 IU and 500,000 IU.
- Suppositories for rectal use 250,000 IU and 500,000 IU.
pharmachologic effect
What is Nystatin? This is an antibiotic of the polyene series with antifungal activity, containing the active substance of the same name. The drug is active against the yeast-like Candida fungi. Ineffective against bacteria. Has fungistatic effect. Resistance of fungi to the drug develops slowly.
The structure of nystatin contains double bonds, which determine the tropism for the formations of the cell membrane of fungi - a molecule of the substance is incorporated into the membrane and forms channels for the transport of electrolytes into the cell. An increase in osmolarity within it leads to death. The cell is lysed, losing resistance to external osmotic forces.
What is Nystatin used for?
Indications for the use of tablets and ointments include:
- Candidiasis with prolonged treatment with antimicrobial drugs, especially in debilitated and malnourished patients (prevention).
- Candidiasis of the mucous membranes and skin.
- Internal candidiasis.
Vaginal suppositories are prescribed for pathologies such as:
- Fungal complications during local antimicrobial therapy (prevention).
- Vaginal candidiasis.
Rectal suppositories help with:
- Fungal lesions in the pre- and postoperative periods (prevention).
- Lower intestinal candidiasis.
Instructions for use
Nystatin for the treatment of candidiasis of internal organs is prescribed orally, regardless of food intake. Adults are prescribed 500,000 IU 4-8 times a day.
With generalized candidiasis, up to 6,000,000 units are prescribed per day. Children aged 1-3 pills appoint 250,000 IU 3-4 times a day, over the age of 3 years - 250,000-500,000 IU 4 times a day. The duration of treatment is 10-14 days. If necessary, repeat the course of treatment in a week.
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In the treatment of candidiasis of the skin and mucous membranes ointment apply a thin layer to the affected areas 2 times a day, daily for 7-10 days. The use of the ointment can be combined with the intake of Nystatin inside. 
Vaginal suppositories injected into the vagina after hygiene procedures, 1 candle 2 times a day (morning and evening). The course of treatment is 10-14 days.
Rectal suppositories injected deep into the rectum 1 suppository 2 times a day (morning and evening). The course of treatment is 10-14 days. If necessary, repeated courses of treatment are carried out.
Contraindications
Taking medication is contraindicated in several pathological and physiological conditions of the body, which include:
- Pancreatitis is an inflammation of the pancreas.
- Individual intolerance to the active substance or auxiliary components of the drug Nystatin, from which the tablets can cause side effects.
- Severe violation of the functional activity of the liver.
- Pregnancy at any stage of its course.
- Peptic ulcer of the duodenum or stomach, accompanied by the formation of a defect in their wall.
Important! Before starting the use of Nystatin, you should make sure that there are no contraindications.
Side effects
- Allergic reactions: chills, pruritus, fever.
- Digestive system: vomiting, nausea, diarrhea (for tablets and rectal suppositories).
- Others: there is a possibility of the spread of resistant forms of fungi, which may lead to the cancellation of therapy.
Children, during pregnancy and breastfeeding
The drug is contraindicated during pregnancy. Allowed in childhood. Children aged 1 to 3 years are prescribed 250,000 IU 3 - 4 times a day, from 3 years and older, 250,000 - 500,000 IU 4 times a day. Duration of treatment is 10-14 days. If necessary, repeat the course of treatment in a week.
special instructions
In cases of side effects, it is necessary to reduce the dose or cancel the therapy. You should not interrupt treatment with vaginal suppositories during menstruation. In case of fungal diseases of the vagina, it is recommended to carry out simultaneous treatment of the sexual partner. During the period of therapy, it is necessary to avoid sexual intercourse.
Drug interactions
Hydrocortisone reduces the effect of nystatin, and it decreases the activity of clotrimazole. Candles are chemically incompatible with hydrogen peroxide, potassium permanganate, salicylic and lactic acids, sodium bicarbonate.
Analogues of the drug Nystatin
- Miconazole.
- Clotrimazole.
- Natamycin.
- Ketoconazole.
- Fluconazole.
- Intraconazole.
- Left.
Vacation conditions and price
The average price of Nystatin (candles v. 10 pcs.) In Moscow is 120 rubles, ointment 30 g - 75 rubles, tablets 20 pcs. - 43 rubles. In Kiev, you can buy a medicine for 17 hryvnia, in Kazakhstan - for 570 tenge. Pharmacies in Minsk offer the drug for 1.5 BYN. ruble.
Dispensed by prescription. Store in a dry, dark place and out of reach of children. Tablets at a temperature of + 18 ... + 25 ° С, suppositories and ointments at a temperature not higher than + 5 ° С. Shelf life: tablets and suppositories - 2 years, ointment - 3 years.
Vaginal suppositories Nystatin- antiseptic and antimicrobial agent for the treatment of gynecological diseases.
Polyene antifungal antibiotic highly active against yeast-like fungi of the genus Candida. Has fungistatic effect. Ineffective against bacteria.
Mechanism of action. The structure of the antibiotic contains a large number of double bonds, which determine the high tropism of the substance to sterols of the cytoplasmic membrane of fungi, which promotes the incorporation of the drug molecule into the cell membrane with the formation of many channels that contribute to the uncontrolled transport of water, electrolytes and non-electrolytes. The cell loses its resistance to external osmotic forces and dies.
Tolerance develops very slowly.
Pharmacokinetics
When applied topically, it is practically not absorbed through the mucous membranes.Indications for use
Candles Nystatin used in the treatment of vaginal candidiasis; for the prevention of fungal complications during long-term antimicrobial therapy (including intravaginal).Mode of application
Suppositories Nystatin administered intravaginally, adults are usually prescribed 250,000 IU - 500,000 IU 2 times a day (morning and evening after hygiene procedures). The duration of the course of treatment is 10-14 days.Side effects
Local reactions: rarely - irritation of the vaginal mucosa, allergic reactions.Contraindications
:Contraindications to the use of suppositories Nystatin are: hypersensitivity to the drug, the first trimester of pregnancy.
Pregnancy
:Application of the drug Nystatin in the II and III trimesters of pregnancy and during lactation, it is possible if the potential benefit to the mother outweighs the possible risk to the fetus and child.
Interaction with other medicinal products
With simultaneous use Nystatin and clotrimazole, the activity of the latter is reduced.Overdose
:About cases of drug overdose Nystatin not reported.
Storage conditions
Store in a dry and dark place at a temperature of 15-25 ° C.Keep out of the reach of children.
Release form
Nystatin - vaginal suppositories.5 vaginal suppositories in a PVC / PE film blister.
2 blisters in a cardboard box.
Composition
:1 vaginal suppository Nystatin contains:
Active substance: nystatin 250,000 IU or 500,000 IU.
Excipients: butyloxyanisole, butyloxytoluene, citric acid, liquid paraffin, semi-synthetic glycerides - up to 2.0 g.
Additionally
:Treatment should not be interrupted during menstruation.
During the period of treatment, it is recommended to avoid sexual intercourse.
In order to prevent reinfection, simultaneous treatment of the sexual partner is recommended.
main parameters
| Name: | NISTATIN CANDLES |
| ATX code: | G01AA01 - |
Very often, women acquire various kinds of diseases. As a rule, with a weakening of immunity, a woman acquires gynecological diseases, including genital infections. One of the most common diseases at the moment is candidiasis.
This is a disease related to the type of infectious disease. Candidiasis contributes to damage to the mucous membrane, skin, nails and internal organs of a woman. Candidiasis is also a type of fungal infection. Very often, women are faced with a disease such as, scientifically, and called candidiasis.
Accordingly, in order to need not only competent treatment, but also effective drugs. Antifungal antibiotics are needed to treat these conditions. One of these drugs is Nystatin.
Description
Nystatin is a drug that comes in various forms. Such a drug is classified as an antifungal type of drug.
The use of Nystatin is most often used in gynecology and proctology. It is used to treat a disease such as thrush. This genital infection is caused by the yeast-like Candida fungi.
Medicinal composition and release forms
The medicinal product is available in the following forms:
- In the form of vaginal and rectal suppositories that can comprehensively affect the infection. The candles are packed in special cells in the amount of five pieces. One package contains detailed instructions on how to take the medicine. Such candles are produced in the form of a torpedo, with a yellowish tint.
- In tablet form. Dragee coated with a light yellow color. The tablets have a slight vanillin smell. These tablets are available commercially in the amount of twenty pieces in dark glass bottles. Also, tablets are available for sale in special contour cells in a packaging cardboard box.
- In the form of an ointment... The ointment is intended for external use. The composition of the drug is brownish-yellow in color. Produced in specially designed tubes.
Nystatin
Composition:
- As part of one tablet contains nystatin, as well as auxiliary, additional components in the form of milk sugar, magnesium carbonate, potato starch, vanillin and other components.
- As part of one candle for rectal administration the composition contains nystatin and auxiliary components in the form of propyl ether and paraoxybenzoic acid. Also in the composition of additional components there is citric acid, as well as liquid paraffin.
- As part of one vaginal suppository there is nystatin and auxiliary components in the form of propyl ester on paraoxybenzoic acid, as well as citric acid.
- As part of one gr. external ointment there is nystatin and an auxiliary component in the form of anhydrous lanolin and medical petroleum jelly.
Pharmacological properties
Nystatin is a topical antifungal drug. This drug is a group of polyenes. In the case when nystatin enters the mucous membrane, a process is started that allows the active active ingredient of the drug nystatin to be slowly released.
The drug begins to penetrate the cell membranes of the pathogens inside, which caused the infection. Subsequently, the drug violates permeability. This process leads to the cessation of further development and reproduction of the infection, as well as, subsequently, to its complete destruction.
The drug is quite highly effective in comparison with other drugs and is very resistant against yeast-like fungi.
Types of candles Nystatin
The manufacturer of the drug nystatin produces quite a variety of forms of the drug that are suitable for any patient. Most often, suppositories are used in gynecology.
So, the drug has a complex effect on the body and penetrates in full through the walls of the mucous membrane. By this, the active substance begins to destroy the infection and stops its further development.
The difference between vaginal suppositories and rectal suppositories
As noted earlier, Nystatin is available in the form of suppositories for both rectal and vaginal use. What is the difference?
Very often, doctors prescribe treatment with suppositories of the rectal and vaginal types at the same time. A feature is that suppositories must be purchased of two types and in no case should suppositories for vaginal administration be inserted into the rectum.
If the doctor prescribed to introduce suppositories in the morning - by the rectal method, in the evening - intravaginally, then in no case should one pack of suppositories intended for rectal administration be enough. You cannot confuse and interfere with the candles.
Indications for use
Suppositories are prescribed to patients directly for both vaginal and rectal administration.
The indications are based on factors such as:
Use of the drug among pregnant and lactating women
As you know, pregnant women and women during breastfeeding need increased attention from doctors. In addition, the doctor should regularly examine such women and monitor their health. It is known that during pregnancy, women have a lot of contraindications.
The use of a medicine such as Nystatin is not recommended in any trimester of pregnancy.
Despite the fact that studies have been carried out and no effect on the gestating fetus has been noted. Suppositories are recommended to be taken only in situations where there is an acute indication for this.
Before starting the therapy process, the doctor should assess the level of risk and benefit of this medication for women. During breastfeeding, the use of suppositories such as Nystatin is allowed only in consultation with the doctor.
There is no information that the composition of the drug comes out with milk. If therapy cannot be postponed for another period, then it is better to stop breastfeeding for a while.
Childhood use
It's no secret that candidiasis also appears in girls at an early age. Treatment at this age is especially important to choose correctly and competently. As noted earlier, Nystatin is produced not only in the form of suppositories, but also in tablet form and in the form of ointments.
If for any reason the use of a suppository is contraindicated, then you can choose any other form of release of the drug Nystatin. The use of suppositories is allowed for children as prescribed by a doctor.
It is forbidden to independently prescribe treatment for a child. The physician should examine the young patient. Only a doctor can prescribe treatment for a young girl with such suppositories as Nystatin.
Method of application and dosage of the drug
A drug such as Nystatin is used in two ways: intravaginally and rectally. The method of taking depends, first of all, on the indications and prescription of the doctor.
To take this drug, the patient needs to lie down in a comfortable position and insert the suppository at a deep distance into the rectal cavity or into the vagina.
It is necessary to inject the drug one by one twice a day. After the drug has been injected, the patient must remain in the same position in order for the drug to dissolve and not leak out.
The course of therapy can continue during the time that is prescribed directly with the doctor.
According to the instructions, the treatment is on average about two weeks. If there is no therapeutic effect or the condition has worsened, the patient should consult a doctor. It should also be borne in mind that during therapy with this drug, discharge may be increased. According to the doctor's prescription, the course of therapy can be prescribed again.
Contraindications
Of course, before you start using a particular drug, you need to familiarize yourself with the list of contraindications.
In fact, Nystatin is a harmless drug that, as such, has no limitations.... When using Nystatin suppositories, the patient must consult a doctor and obtain permission.
The drug is contraindicated in the following cases:
- with diseases of a vital organ - the liver, which is accompanied by a malfunction of the organ itself;
- the period of bearing the baby and the period of breastfeeding;
- lack of perception of any components that make up the basis of the drug;
- with blood particles from the genital tract, the nature of which has not been examined and is not known.
- inflammatory processes of hemorrhoidal nodules;
- the presence of discharge with blood from the anus;
- the presence of malignant neoplasms in the rectum.
Side effects
Side effects can occur in any patient after taking a particular drug. It should be noted that the side effects can be absolutely any. After all, someone does not tolerate the drug at all, while someone may have complications after a period of treatment.
Like any other drug, Nystatin also has a number of side effects that can occur after using the drug, as well as during treatment. In general, this drug is quite well tolerated by patients when the dose is observed in accordance with all the rules.
Those patients who have increased individual sensitivity may develop side effects such as:
- burning sensation and itching in the vaginal area;
- swelling of the mucous membrane;
- urge to defecate;
- a feeling that there is a foreign body in the colon.
In adults with liver disease, the first disease develops - liver failure.
To avoid side effects did not appear in the patient, it is necessary not only to observe the dosage, but also to take the drug correctly. To do this, you must follow the treatment regimen prescribed by your doctor.
Overdose
It should be noted that the dosage for each patient can be set individually. A drug such as Nystatin in the form of suppositories begins its action and effect when absorbed into the human blood system.
Even in spite of the fact that the candles will be used for a long time, an overdose is almost impossible.
If you accidentally consume candles inside, you urgently need to induce a gag reflex and drink activated charcoal.
Interaction of the drug with other drugs
Quite often, when prescribing treatment, doctors prescribe several drugs that can overcome the disease.
It is worth making a reservation, drugs that help to eradicate the problem of candidiasis have active substances. It is due to such circumstances that not all groups of drugs are compatible. Especially when it comes to drugs for the treatment of genital infections.
A drug such as Nystatin in gynecological practice is not recommended to be used in parallel with the drug . It is worth noting an important factor - the presence of a sufficiently highly active substance that can displace the active substances of other drugs.When the two drugs interact, the effectiveness of Clotrimazole is significantly reduced.
special instructions
The drug Nystatin is one of the drugs tested over the years, inexpensive, affordable for anyone, and the composition and pharmacological properties are not nearly inferior to modern drugs.
Special instructions for use:
Analogs of candles Nystatin
Despite the fact that the drug is sold in pharmacies at a fairly affordable price, there are analogues to this drug and most give their choice to analogues. This is due to the fact that Nystatin in any form is not suitable for every patient. Not everyone is able to tolerate the active substance of the drug.
Like many other drugs, Nystatin has its own analogues that can replace this drug.
According to the therapeutic effect, drugs can also be selected as:
- Pimafucin;
- Nitrofungin;
- Moronal.
Nitrofungin
Pimafucin (Natamycin)
These drugs have increased activity in the treatment of candidiasis. It is not recommended to change medicines on your own, you need to consult a doctor.
Nystatin - suppositories, instructions for use for this dosage form provide some features of use and describe in detail the cases in which the medicine will be really useful. Suppositories with Nystatin from thrush are a popular and common remedy prescribed by gynecologists and proctologists to suppress the activity of yeast-like fungi, whose activity in the human body leads to the development of candidiasis.
Candidiasis are pathological processes that lead to the appearance of negative symptoms caused by the presence of a mycotic infection. A conditionally pathogenic fungus of the genus Candida, under the influence of endogenous and exogenous factors, turns into a pathogenic in the body, and leads to the development of inflammatory processes that spread to the mucous membranes and skin of a person.
The active active ingredient of suppositories is nystatin, which has significant activity against fungal infection, and is available in various dosage forms, including suppositories for rectal and vaginal use.
Medicinal composition, release form
In modern medicine, several dosage forms are used with the active active ingredient nystatin, the dosage of which can be 250 or 500 thousand units. depending on the packaging of suppositories or another type of drug. The dosage form contains a certain amount of excipients: vaseline oil, butyloxyanisole, citric acid, butyloxytoluene, semisynthetic glycerides, which is due to the specificity and localization of the use of the antifungal agent.
When asked whether Nystatin is an antibiotic or not, the attending physician usually characterizes the active substance of the suppositories as a polyene antibiotic. The group to which it belongs has a directed action, mycocidal and simplecidal, which makes it possible to successfully suppress the activity of the fungus, due to its ability to destroy the cell membranes of mycoses.
The suppository can be purchased in a cardboard box with enclosed instructions for use and contour blisters, in which 5 candles are usually placed. In a pack there are 2 packages, the blister can be polyethylene or polyvinyl chloride.
pharmachologic effect
Nystatin does not show activity against bacterial infections, like other antibiotics of the polyene series. Its main action is antifungal, achieved due to the specific features that are realized during the release of nystatin. Getting on the mucous membrane, the active active substance penetrates to the causative agent of the infection, at the same time:
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- disrupting the permeability of cell membranes;
- using double bonds of its own structure for tropism (incorporation into the membrane and the formation of a channel for intracellular electrolyte transport);
- destroying the cell by increasing osmolarity;
- lysing a cell that loses its stability and dies.
In gynecological and proctological practice, it is positioned as an antibiotic of the polyene series with pronounced antifungal, antiseptic and antimicrobial properties, with predominant activity against candidiasis, fungistatic, inactive against bacterial infections.
Contraindications
The main contraindication is pregnancy and lactation. During lactation, due to the insignificant ability to be absorbed into the blood and the lack of information about excretion from the body with breast milk, Nystatin vaginal suppositories can be used only when breastfeeding is stopped for the duration of the drug. In some sources, contraindications indicate pancreatitis, stomach and duodenal ulcers, liver failure. It is definitely not used in the presence of individual immunity to individual components of the drug or to the active active ingredient.
Relative contraindications are the presence of vaginal or anal discharge of unclear etiology, hemorrhoids in the acute stage, suspicion of oncological rectal processes.
Nystatin candles: instructions for use
The instructions attached to any dosage form contain detailed instructions on how to take Nystatin in order to achieve the maximum therapeutic effect. Depending on the use in proctological or gynecological practice, different Nystatin suppositories are prescribed, for which suppositories are used rectally or intravaginally, by the method of deep injection. The duration of the course is usually 14 days, but it can be increased to achieve therapeutic goals, or it can be recommended again, after a break, if necessary.
With thrush
One of the most common prescriptions in gynecological practice is Nystatin suppositories for thrush. Reviews of the effectiveness of the action are received already on the 3-4th day, however, the duration of a two-time daily intake is always determined at 2 weeks. Usually, the use of suppositories is recommended for both sexual partners to destroy the source of infection. If necessary, the daily therapeutic dose can be increased up to 3-4 times.
For gynecology
Vaginal suppositories Nystatin are used, indications for use provide for the absence of petroleum jelly in the composition. In obstetrics and gynecology, it is prescribed as a remedy against thrush, a way to prevent the occurrence of candidiasis after surgery and the treatment of bacterial infections. Both types of Nystatin suppositories can be used, the indications of which will give a simultaneous therapeutic and prophylactic effect in case of the threat of the spread of a fungal infection from the vagina.
During pregnancy
During the period of bearing a child, other medicines are recommended for use. Nystatin is rarely used during pregnancy, provided that the hypothetical benefit outweighs the expected harm. Clinical studies have not revealed a teratogenic effect of Nystatin, but, despite this, in the question of Pimafucin or Nystatin, which is better, in this period, preference for use is given to Pimafucin, as it is less harmless.
Suppositories Nystatin: side effects
Side effects (rarely) may include itching, redness, rashes, burning sensations, subjective sensations such as a feeling of a foreign body in the anus or the urge to defecate (with rectal use).
Overdose
Cases of overdose with rectal and vaginal suppositories have not been recorded.
Compatibility of suppositories with other medicines
Suppositories with Nystatin significantly reduce the activity of Clotrimazole, so they are not recommended to be consumed at the same time. At the same time, douching significantly negates the therapeutic effect of suppositories.
Candles Nystatin: analogues
Industrial analogues of Nystatin suppositories are vaginal suppositories: Pimafucin, Moronal, Nistafungin, Fungicidin and Terzhinan, which contain another active ingredient, but a similar therapeutic effect is achieved when applied.
How to store candles, terms of sale
Sold in a pharmacy, with a doctor's prescription. Stored in a cool, dark place with a storage temperature not exceeding 100C, out of reach of children and out of direct sunlight. Shelf life is 24 months, after the expiration of the period indicated on the package, use is not recommended.
Nystatin candles: price
The price of the drug may vary depending on the region of residence, dosage, and the margin applied in a particular retail pharmacy network. In Moscow, it starts at 45 rubles, but in other regions it may be lower.
Nystatin candles: reviews
There is a persistent and stable effect of using the drug against vaginal and anus candidiasis with lesions of any severity by fungi of the genus Candida, better known under the collective name thrush. Suppositories give excellent results when used prophylactically to prevent the negative consequences arising from prolonged drug therapy with antibacterial drugs and antibiotics of other groups.
Favorable reviews are also met by therapy when applied with the help of an active substance suppository of candidiasis, arising in the form of lesions of the mucous membrane of the large intestine. Practicing surgeons approve of the activity of the dosage form in the prevention of candidal formations, which often occur after surgical interventions performed on the large intestine.
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