Piobacteriophage instructions for use. Piobacteriophage complex. Contraindications and precautions

Biofag DP Immunopreparation GUP Immunopreparation, GUP microgen NGO, FSUE Ministry of Health of Russia G.PUM MICROGEN NGO, FSUE Ministry of Health of Russia G. Ufa Microgen NGO, FSUE Ministry of Health of Russia Nizhny Novgo

Country of origin

Russia

Group of goods

Immunobiological drugs (ILP)

Medical Immunobiological Preparation (MIBP) - Bacteriophage

Forms of release

The solution for receiving inside, local and outdoor use, the bottle is 100ml - 1 pcs in the UE. The solution for intake, local and outdoor use, the bottle is 20 ml - 4 pcs in UE.

Description of the dosage form

Bacteriophage is a transparent yellow liquid of various intensities with a specific taste of the nutrient medium, without bitterness; , Solution for receiving inside and local application for intake, local and outdoor use

pharmachologic effect

Piobacteriophage complex has the ability to specifically lyse the bacteria of staphylococci, streptococci, enterococci, the perfoch, klebseyell pneumonia and oxite, and sinny and intestinal sticks. Application during pregnancy and in the period, breastfeeding. It is advisable to use the drug, during pregnancy and in the period of breastfeeding.

Special conditions

The autopsy of the vials and ampoules, the procedure for administering piobacterophage polyvalent, is carried out with strict compliance with the rules of antiseptics. The use of piobacterophage polyvalent does not exclude the use of other antibacterial and anti-inflammatory drugs. Before use of the bottle with liquid bacteriophage, you need to shabby. When clouding, do not drink! Effect on the ability to drive vehicles and managing mechanisms information about the possible effect of the drug on the ability to control vehicles, there are no mechanisms.

Structure

mixture was sterile filtrates fagolizatov bacteria Staphylococcus, Streptococcus, Enterococcus, Proteus (P. vulgaris, P. Mirabilis), Pseudomonas aeruginosa, enteropathogenic Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca mixture was sterile filtrates fagolizatov staphylococci, streptococci, enterococci, Proteus, Klebsiella (pneumoniae and oxite), sinny and intestinal sticks 20 ml Preservative: Hinosol 0.0001 g / ml

Piobacteriophage testimony for use

Treatment and prevention of purulent-inflammatory and intestinal diseases caused by staphylococci, enterococci, streptococci, a blue rod, klebseyellala, pathogenic intestinal wand of various serogroups, internally, internal, rectal and outdoor use. - Earburning ear, throat, nose, respiratory tract and lungs - inflammation of the sinuses of the nose, middle ear, angina, pharyngitis, laryngitis, tracheit, bronchitis, pneumonia, pleurisy; - Surrigic infections - suppuration of wounds, burns, abscess, phlegmon, furuncula, carbuncules, hydroenets, panaria, paraproititis, mastitis, bursitis, osteomyelitis; - Moorenital infections - urethritis, cystitis, pyelonephritis, colpit, endometritis, salpingooforitis; -Postraumatic conjunctivitis, keratoconjunctivitis, purulent corneal ulcers and iridocyclites; -Entheral infections - gastroenterocolitis, cholecystitis, dysbacteriosis; -Enamed septic diseases; - Night-inflammatory diseases of newborns - ommopalitis, pyodermia, conjunctivitis, gastroenterocolitis, sepsis, etc.; -S.

Dosage form: & nbspsolution for intake, local and outdoor use Structure:

In 1 ml of the drug contains:

Active substance:

Sterile peeled filtrates of phagoolisate bacteria Staphylococcus, Enterococcus, Streptococcus, enteropathogenic Escherichia Coli, Proteus Vulgaris, Proteus Mirahilis (with an activity of Appevman - at least 10 -5), Pseudomonas Aeruginosa, Klebsiella Pneumoniae, Klebsiella Oxytoca(With an activity of Applman - at least 10 -4) - up to 1 ml.

Excipients: preservative - 8-hydroxychinoline sulfate - 0.0001 g / ml (content estimated);or 8-hydroxychinoline monohydrate sulfate in terms of 8-hydroxychinoline sulfate - 0.0001 g / ml (content is calculated).

Description: Transparent yellow liquid of different intensities, a greenish tint is possible. ATH: & NBSP

Other different drugs

Pharmacodynamics:

The drug causes specific lysis bacteriaStaphylococcus., Enterococcus, Streptococcus, EnteropathogenicEscherichia.coli., Proteus.vulgaris, Proteus.mirabilis., Pseudomonas.aeruginosa., Klebsiellapneumoniae., Klebsiellaoxytoca..

Indications:

Treatment and prevention of purulent-inflammatory and intestinal diseases caused by staphylococci, enterococci, streptococci, a blue rod, klebseyellala, pathogenic intestinal wand of various serogroups, internally, internal, rectal and outdoor use.

Diseases of the ear, throat, nose, respiratory tract and lungs - inflammation of the sinuses of the nose, middle ear, angina, pharyngitis, laryngitis, tracheitis, bronchitis, pneumonia, pleurisy;

Surgical infections - wound suppurations, burns, abscess, phlegmon, furuncula, carbuncules, hydraulic, panaria, paraproatitis, mastitis, bursitis, osteomyelitis;

Urogenital infections - urethritis, cystitis, pyelonephritis, colpit, endometritis, salpingo-phorite;

Post-traumatic conjunctivitis, keratoconjunctivitis, corneal purulent ulcers and iridocyclitis;

Enteral infections - gastroenterocolite, cholecystitis, dysbacteriosis;

Generalized septic diseases;

Purulent-inflammatory diseases of newborns - ommopalite, pyodermia, conjunctivitis, gastroenterocolitis, sepsis, etc.;

Other diseases caused by the bacteria of staphylococci, streptococci, enterococci, a flow, Klebsiell pneumonia and oxite, and sinic and intestinal sticks.

The preventive purpose is used to handle operating and fresh-infected wounds, as well as for the prevention of nosocomial infections on epidemic testimony.

Contraindications:

Hypersensitivity to the components of the drug.

Pregnancy and lactation:

It is advisable to use the drug during pregnancy and in the period of breastfeeding.

Method of use and dose:

The treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and through the mouth, 7-20 days (under clinical indications).

Depending on the nature of the focus of infection, bacteriophages apply:

1. In the form of irrigation, lotion and tamponation with liquid phage in the amount of up to 200 ml, depending on the size of the affected area. In abscess bacteriophages are administered to the cavity of the hearth after removing the pus by puncture. The amount of injected drug must be somewhat less than the volume of remote pus. With osteomyelitis, after appropriate surgical treatment, bacteriophages of 10-20 ml are poured into the wound.

2. In the cavity in the cavity - pleural, articular and other bounded cavities up to 100 ml of bacteriophage, after which the capillary drainage is left through which bacteriophages are re-introduced within a few days.

3. Print cystitis, pyelonephritis, urethritis preparation is taken inward. In the event that the urinary bubble or renal pellet cavity is drained, the bacteriophages are administered through cystomate or nephrostable 1-2 times a day at 20-50 ml in the bladder and 5-7 ml into the renal pelvis.

4. In the purulent-inflammatory gynecological diseases, the drug is injected into the cavity of the vagina, the uterus at a dose of 5-10 ml daily one-time.

5. In the purulent-inflammatory diseases of the ear, throat, the drug is injected at a dose of 2-10 ml 1-3 times a day. Bacteriophages are used for rinsing, washing, instillation, introduction of moistened turb (leaving them for 1 hour).

6. In conjunctivitis and keratoconjunctivitis, the drug is buried by 2-3 drops 4-5 times a day, with a purulent cornea ulcer - 4-5 drops, with purulent iridocyclite, the drug is used 6-8 drops every 3 hours in combination with intake intake.

7. In the treatment of stomatitis and chronic generalized periodontitis, the drug is used in the form of rinsing of the oral cavity 3-4 times a day at a dose of 10-20 ml, as well as the introduction of turf in the periodontal pockets impregnated with piobacteriophage, for 5-10 minutes.

8. Print intestinal forms of disease, diseases of internal organs, dysbacteriosis bacteriophages are used through the mouth and in the enema. Through the mouth, the bacteriophages give on an empty stomach 3 times a day before meals. In the form of enema prescribed 1 time per day instead of one reception through the mouth.

Age	Dose 1 reception (in ml)
Age	through Roth.	in enema
Up to 6 months
From 6 months to 1 year
From 1 year to 3 years
From 3 to 8 years
From 8 years and older

The use of bacteriophages does not exclude the use of other antibacterial drugs. In the event that, before the use of bacteriophage for the treatment of wounds, chemical antiseptics were used, the wound should be thoroughly rotated with a sterile 0.9% sodium solution of chloride.

Application of bacteriophage in children (up to 6 months)

When sepsis, enterocolite newborns, including premature bacteriophages, the bacteriophages are used in the form of high enema (through a gas pipe or catheter) 2-3 times a day (see Table). In the absence of vomiting and tightening, it is possible to use the drug through the mouth. In this case, it is mixed with breast milk. Perhaps the combination of rectal (in the enema) and oral (through the mouth) of the use of the drug. Course of treatment 5-15 days.

With the recurrent course of the disease, repeated courses of treatment are possible.

In order to prevent sepsis and enterocolitis during intrauterine infection or the risk of the occurrence of a non-hospital infection in newborns, bacteriophages are used in the form of 2.3 days a day for 5-7 days.

In the treatment of ommopalites, pyodermia, infected with the Russian Academy of Sciences, the drug is used in the form of applications daily twice (gauze napkin is wetted by bacteriophage and impose on the umbilical wound or on the affected skin).

Side effects:

Not installed.

Overdose:

Notinstalled.

Interaction:

The use of the drug is possible in combination with other drugs, including antibiotics.

Special instructions:

An important condition for effective phageotherapy is the preliminary determination of the sensitivity of the pathogen to bacteriophage and the early use of the drug.

It is not suitable for use drug in bottles with impaired integrity or marking, with an expired expiration date, during turbidity.

Due to the content in the drug of the nutrient medium, in which bacteria from the environment can develop, causing clouding the drug, it is necessary to observe the following rules when opening the bottle:

Wash your hands thoroughly;

Handle the cap with alcohol-containing solution;

Remove cap unopened corks;

Do not put the plug in the inner surface on the table or other items;

Do not leave the bottle open;

Opened bottle to store only in the refrigerator.

Before using the bottle with bacteriophage, you must shake and view. The drug must be transparent.

Opening the vial and extraction of the required volume of the drug can be carried out with a sterile syringe by puncture through the cork. The drug from the opened vial when complying with the storage conditions, the above rules and the absence of turbidity can be used during the entire expiration date.

Impact on the ability to control the transc. cf. And Meh.:

No information.

Release form / Dosage:Solution for intake, local and outdoor use. Packaging:

In bottles of 20 or 100 ml.

8 bottles of 20 ml or 1 vial 100 ml in a pack of cardboard with instructions for use.

Storage conditions:

At temperatures from 2 to 8 ° C in a place protected from light and inaccessible to children.

Terms of transportation

At temperatures from 2 to 8 ° C, transportation is allowed at a temperature of from 9 to 25 ° C for no more than 1 month.

Shelf life:

The preparation with an expired application is not subject to use.

Conditions of vacation from pharmacies:Without recipe Registration number:LS-000700. Registration date:21.06.2010 / 24.05.2018 Execution Date:Durable Registration Certificate Owner:Microgen NGO, JSC Russia Manufacturer: & NBSP Date of updating information: & NBSP24.01.2020 Illustrated instructions

1 ml of the drug contains

active substance:

The mixture of sterile filtrate phagelizates of bacteria:

Escherichia coli.

Pseudomonas Aeruginosa,

phag Titre at least 1x106;

auxiliary: no

Description

Transparent yellow liquid of various intensities with a specific taste.

Pharmacotherapeutic group

Antibacterial drugs for system use.

Other antibacterial drugs

Code ATX J01XX

Pharmacological properties

Pharmacokinetics

Regardless of the method of administration, the preparations of bacteriophages penetrate into blood and lymph and fall into the focus of inflammation. The main part of the drug is excreted by the kidneys, having a sanitating effect on the urinary pathways, and the rest is through the gastrointestinal tract.

Pharmacodynamics

Bacteriophage is a specific bacterium virus that is adsorbed on the cell membrane of the homologous bacterium, penetrates the cell and lysides it. The Pio Bacteriophage Liquid includes selective, only virulent bacteria phages: Streptococcus, Staphylococcus, Escherichia Coli, Pseudomonas Aeruginosa, Proteus, which ensures high activity and efficacy of the drug.

Indications for use

Treatment and prevention of purulent-inflammatory diseases caused by Bacteria Streptococcus, Staphylococcus, Escherichia Coli, Pseudomonas Aeruginosa, Proteus

ENT infections and respiratory tract (inflammation of the sinuses of the nose, middle ear, angina, pharyngitis, laryngitis, tracheit, bronchitis, pneumonia, pleurisy)

Surgical infections (purulent wound, burn, abscess, phlegmon, furuncle, carbuncoon, hydraulic, panarium, paraproatitis, mastitis, bursitis, osteomyelitis)

Urogenital infections (urethritis, cystitis, pyelonephritis, colpit, endometritis, salpingoophoritis)

Infections of the gastrointestinal tract (stomatitis, paradontitis,

cholecystitis, enterocolitis, intestinal dysbiosis)

Generalized septic diseases

Purulent-inflammatory diseases of newborns (ommopalite, pyoderma, conjunctivitis, sepsis)

Processing of fresh wounds for the prevention of purulent complications in surgical manipulations and operations

Prevention of bacterial complications with sharp respiratory

viral diseases

Method of application and dose

An important condition for the successful use of bacteriophage preparations is to determine the phagezensitivity of the pathogen and earlier the use of the drug. The drug is particularly effective in the initial stage of the disease and when applied directly in the focus of the lesion.

Pio bacteriophage liquid is prescribed for intake (through the mouth, in the form of enema), locally (in the form of rinsing, irrigation, lotions), for administration to the cavity (wound, abscess, abdominal, pleural cavity, phlegmon, nose, nose sinuses, middle ear , bladder, uterus, vagina).

For the treatment of mint-resistant diseases with local lesions, the bacteriophage liquid is assigned simultaneously: both locally, so for intake (PER OS). The duration of the course of treatment with a drug from 5 to 10 days.

The dosage is determined individually, depending on the size of the affected area. The drug is introduced into the head cavity after removing pus by puncture. The amount of injected drug must be somewhat less than the volume of remote pus.

In the following days, the drug is introduced into an infected cavity, with the help of drainage.

The procedure is carried out once a day, within 3-5 days.

· With cystitis, pyelonephritis, urethritis preparation is accepted inside.

In the event that the urinary bubble or kidney pellet cavity is drained, bacteriophages are introduced 2 times a day at 20-30 ml in the bladder and 5-10 ml into the renal pelvis;

· For purulent-inflammatory gynecological diseases, the drug is introduced into the cavity of the vagina, the uterus, in a dose of 5-10 ml daily, one-time.

· With purulent-inflammatory diseases of the ear, throat, the nose The drug is introduced at a dose of 2-10 ml 1-3 times a day. Bacteriophages are used for rinsing, washing, instillation, introduction of moistened turb (leaving them for 1 hour). For the treatment of purulent tonsillitis, the drug is used for rinsing and is also assigned to PER SO, at the same time.

· In the treatment of stomatitis and chronic generalized periodontitis, the drug is used in the form of rinsing of the oral cavity 3-4 times a day at a dose of 10-20 ml, as well as administered to periodontal turtle pockets, impregnated with piobacteriophage, for 5-10 minutes.

· In the intestinal forms of the disease, diseases of internal organs, dysbacteriosis, Pio bacteriophage liquid is used through the mouth and in the enema.

The drug is given to drink an empty stomach, 1 hour before meals.

In the form of enema is appointed 1 time per day, in the evening, before bedtime, after the intestinal emptying.

Dose drug for preventive use

determined by the doctor.

Note

In case, before applying the drug Pio bacteriophage for the treatment of wounds, chemical antiseptics were used, the wound should be thoroughly rotated with a sterile 0.9% sodium solution of chloride.

Side effects
Preparations of bacteriophages are non-toxic. Unwanted effects and reactions associated with the use of Pio bacteriophage liquid are not marked.

Contraindications

Hypersensitivity to any component of the content of the bottle of the drug.

Medicinal interactions

Interaction with other drugs of bacteriophage drugs is not established. Pio bacteriophage liquid can be used with other drugs, including antibacterial drugs.

special instructions

When clouding, the drug does not apply!

Wash your hands thoroughly;

Handle the cap with alcohol-containing solution;

Remove the cap without opening the plugs;

Do not put the plug in the inner surface on the table or other items;

Do not leave the bottle open;

Opened bottle to store only in the refrigerator.

Unfortunately, inflammatory diseases of bacterial origin can hardly be considered a rarity. With such problems, every person comes from time to time, regardless of age, gender or other indicators. So what means of treating such aids offer modern medicine?

Today, preparations based on bacteriophages are becoming increasingly popular. And quite often, doctors are prescribed by their patients "Piobacteriophage" medicine. Instructions for use is quite simple, and the effect is really available. But what is the feature of this drug? What is included in his composition? Are there contraindications for therapy? This information will be interesting to many readers.

Description of the composition and form of the release of medication

The preparation "Piobacteriophage complex liquid" is produced as a transparent solution of yellowish color. The liquid is placed in a glass bottle with a capacity of 20 or 100 ml.

This drug is a mixture of bacteriophages that are obtained by lysis bacterial cells. In particular, the solution contains bacteriophages, which are active with respect to enterococci, staphylococci, streptococci, klebseyllam, intestinal wand, pseudomonadam and protouches. The resulting lysate in the production process is thoroughly filtered from the residues of pathogenic cells. Hinosol is used as a support buffer. By the way, the solution must be stored at a temperature of 2-8 degrees Celsius.

What properties is the drug?

What effect can provide a preparation "Piobacteriophage"? The instruction states that the medicine is perfectly coping with various kinds of infections. But why?

In fact, such drugs have unique properties. Bacteriophages - varieties of viruses that affect bacterial cells. Penetrating through the cell wall, the virus begins to reproduce actively using cellular resources for this. This, in turn, leads to the death of bacteria, lysis of their walls and the release of new viral particles.

It is also worth noting that the action of bacteriophages is highly specific. Viral particles affect only certain bacterial cells, at the same time without affecting the structures of the body or useful bacteria that are necessary to maintain the normal functioning of organ systems.

Indications for use

In what cases do patients prescribe a Piobacteriophage preparation? The use of this tool is quite wide. It is used to treat inflammatory diseases caused by the activity of bacteria sensitive to the phages.

For example, taking medication is shown in intestinal infections. In surgical practice, the drug is used to treat suppurations, burns, carbunculov, phlegmon, furunculus. Also indications for use are infectious angins, otitis, pharyngitis, sinusites, pleurisites, pneumonia, pyelonephritis, cystitis, colpits, salpingooforites, etc.

Preparation "Piobacteriophage": instructions for use

Only a doctor may assign the use of this drug. The specialist will also determine the most efficient dose and therapy duration. So how to properly use the "Piobacteriophage" means? Instructions in this case depends on the form of the disease, the state of the patient and some other factors.

For example, at skin lesions, the solution is used in the form of wet dressings, applications, irrigation, rims, etc.
In the treatment of abscesses, the solution with bacteriophages is administered directly into the cavity of the suppuration, pre-carefully cleaned it from the existing purulent masses.
With diseases of the excretory system, the solution can be introduced directly into renal pelvis or into the urinary bubble cavity.
Also, the drug can be used for instillations, washes, rinsing (for example, throat), irrigation.
In case of intestinal diseases, enema will be effective on the basis of this solution.
Nevertheless, the most often the drug is prescribed orally. In addition, in some diseases, it is advisable to combine several methods of administration at once to achieve maximum result.

One-time dose is determined by the doctor. For adult patients and children over eight years old, it is usually 50 ml. Take the drug three times a day (the number of techniques can decrease if therapy includes other procedures, for example, enemas). The course of treatment in most cases lasts from 5 to 15 days. If we are talking about the prevention of one or another disease, then the seven-day reception will be enough.

Features of the treatment of children under the age of 6 months

Of course, this medicinal product is widely used in pediatrics for the treatment of newborns and children of the first months of life. Treatment "Piobacteriophage" in this case has some features to pay attention to.

In the treatment of enterocolitis or sepsis of newborns (including and premature babies), the method of so-called high enema is used. For the irrigation of the intestine, special catheters are used. A single dose of drug for the enema is 10 ml, the procedure is repeated 2-3 times a day. If vomiting is absent, then the child can give a solution and orally, mixing with a lactic mixture or breast milk - a single dose is 5 ml. Quite often, doctors recommend combining rectal and oral ways to administer the drug. The course of therapy, as a rule, lasts from 5 to 15 days.

Are there any contraindications and side effects?

Of course, many people are interested in the question of whether all the categories of patients are allowed to take the preparation "Piobacteriophage"? The instruction states that this means of contraindications does not have. Moreover, cases of severe adverse reactions were also not registered. Sometimes patients have a small allergic reaction, but it happens extremely rarely.

The preparation "Piobacteriophage complex liquid" is often used to treat even newborn children. Moreover, the drug is indispensable in the process of treating certain infections during pregnancy, because during this period of women's life, traditional antibacterial therapy with antibiotics can only harm.

But, despite all security, you should not use the medicine to use - before starting therapy, you will definitely consult your doctor.

How much is the drug?

For many patients, the question of the cost of a particular medication is important. So how much will the preparation "Piobacteriophage" cost? The price, of course, may fluctuate depending on the volume you buy, the manufacturer, as well as the financial policy of the pharmacy point.

On average, the packaging costs 900 rubles. But it must be borne in mind that to pass the full course of treatment, you will most likely need several such packages.

What if for one reason or another you can not use the "complex liquid piobacteriophage"? Bacteriophage is also contained in some other preparations - if necessary, you can choose a substitute for almost the same properties. For example, such means as "pyobacteriophage polyvalent purified", "piopolyag", "sextafag" and some others are considered good counterparts.

Preparation "Piobacteriophage": reviews of doctors and patients

To date, bacteriophage-based preparations are becoming more and more popular. After all, standard therapy with antibiotics is not suitable for all and often conjugate with side effects. And in such cases, doctors prescribe a dosage "Piobacteriophage". Reviews of doctors are a positive character, as the drug perfectly copes with its main task.

Patients also speak well about this tool. It helps to cope with staphylococcus and other pathogenic microorganisms, does not harm health and practically does not have contraindications. As for negative moments, it is worth mentioning the price that for some patients may be too high. The disadvantages include not too pleasant taste, as well as some difficulties that occur with the storage of the drug. But in any case, health costs all inconvenience.

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Piobacteriophage polyvalent peeled

Before using the bottle with bacteriophage, you must shake and view. The drug must be transparent and do not contain a sediment.

Attention! When clouding, the drug does not apply!

Wash your hands thoroughly;

Handle the cap with alcohol-containing solution; Remove the cap without opening the plugs;

Do not put the plug in the inner surface on the table or other items;

Do not leave the bottle open;

Opened bottle to store only in the refrigerator.

When using small doses (2-8 drops), the drug must be selected with a sterile syringe in a volume of 0.5-1 ml.

The drug from the opened vial while complying with the storage conditions, the above rules and the absence of turbidity can be used during the entire expiration date.

The drug is used to receive inside (through the mouth), in the form of enema, applications, irrigation, administration in the cavity of the wounds, vagina, uterus, nose, nasal sinuses, as well as in drained cavities: abscesses, abdominal, pleural, bladder, renal jelly.

Inside the drug take on an empty stomach for 0.5-1 hours before meals.

The treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and the drug intake.

In the case of processing the cavity of the purulent focus, chemical antiseptics before use of the bacteriophage, it must be a sterile 0.9% sodium solution of chloride.

In the treatment of angina, pharyngitis, laryngitis, the drug is used for rinsing of the oral cavity and pharynx 3 times a day at 10-20 ml, the course of treatment is 7-10 days.

In the treatment of bronchitis, pneumonia is taken inside 3 times a day at 10-20 ml, and also used in the form of aerosols and inhalations (without heating and use of ultrasound), a course of treatment for 15-20 days.

In the treatment of otitis, the drug is used for washing and administered to the cavity of the middle ear of 2-5 ml 1-3 times a day. Course of treatment 7-15 days.

In the treatment of inflammation of the nose sinuses, the drug is used to wash the nasal cavity, nasopharynx, and the nasal sinuses at a dose of 5-10 ml and administration to the sinuses 2-3 ml. The procedure is repeated daily once for 7-10 days. In addition, the drug is introduced into the nasal cavity in the form of turf moistened with bacteriophage, in turn in each nasal stroke and leave for 0.5-1 hours. The procedure is repeated 3 times a day, the course of treatment is 7-15 days.

In the treatment of stomatitis and chronic periodontitis, the drug is used in the form of rinsing of the oral cavity 3-4 times a day at a dose of 10-20 ml, as well as the introduction of Turunch, impregnated with bacteriophage into paradontal pockets, 5-10 minutes, 7-10 days treatment.

In conjunctivitis and keratoconjunctivitis, the drug is used for 2-3 drops 4-5 times a day, the course of treatment is 5-7 days; With a purulent cornea ulcers - 4-5 drops per day for 7-10 days, with purulent iridocyclite - 6-8 drops every 3 hours in combination with intake in the therapeutic dosages for 7-10 days.

With an abscess after opening and removing purulent content, the drug is administered in the amount of less than the volume of remote pus daily once, the course of treatment is 7-10 days.

With peritonitis and pleurite, the drug is injected into the drained cavities - abdominal and pleural through drainage tubes daily once 20-70 ml, treatment course 10-15 days.

When osteomyelitis, the drug is injected into the cavity of the wound through Turundas, drainage in the amount of 10-30 ml daily once, a course of treatment for 15-20 days.

In the treatment of mastitis, suppuration of the Russian Academy of Sciences and burns, the drug is used in the form of irrigation, applications, bandages, introducing into drainage at a dose of 5-50 ml, depending on the focus of the lesion at least once a day, the course of treatment is 10-15 days.

In the treatment of purulent-inflammatory gynecological diseases (wound supplements, endometritis, vulvit, bartolinite, collision, salpingo-phorite) The drug is used for irrigations, applications, injected in cavities of wounds, vagina, uterine 5-20 ml once a day for 7-10 days.

When cystitis, pyelonephritis, urethritis preparation is taken inside in the therapeutic dose 3 times a day 1 hour before meals for 10-20 days. In that case, if the cavity of the bladder or renal izhanki is drained, the drug is administered through cystomate or nephrostable 1-3 times a day at 20-50 ml in the bladder and 5-7 ml into the renal loin, the course of treatment is 7-15 days.

When gastroenterocolite, pancreatitis, cholecystitis, as well as intestinal dysbacteriosis, bacteriophages are taken inside in age dosages 3 times a day 1 hour before meals for 7-15 days (by clinical indications). In case of indoorable vita, the drug is used in the form of high enema 2-3 times a day at 20-40 ml. In the intestinal dysbiosis, the drug can be used with normoflore preparations.

For the prevention of intrabole surgical infections, the drug is used to process postoperative and freshly infected wounds at a dose of 5-50 ml, depending on the lesion focus, once every 5-7 days.

Application of the drug in children up to 1 year (including premature children)

With gastroenterocolite, pneumonia and sepsis of newborns, the drug is used through the mouth 2-3 times a day at 3-5 ml 30 minutes before feeding. In cases of indomitable vomiting, the drug is used in the form of high enema (through a gas-conductive tube or catheter) daily once in a dose of 5-10 ml. Perhaps the combination of rectal (in the form of high enema) and oral administration of the drug. Course of treatment for 7-15 days (under clinical indications). With the recurrent course of the disease, it is possible to re-conduct treatment courses.

In the treatment of omphalitis, pyodermia, infected with wounds, bacteriophages are used in the form of applications of 5-10 ml 2-3 times a day (gauze napkin is wetted with bacteriophage and impose on an umbilical wound or affected skin) for 7-15 days.

In order to prevent the emergence of a nosocomial infection in newborns, bacteriophages apply on epidemic testimony inside 3-5 ml 3 times a day 30 minutes before feeding throughout the duration of stay in the hospital.

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Poolvalent piobacteriophage

Structure

The preparation contains an active substance of piobacteriophage (mixtures of phagelized sterile, streptococcal filtrates, a proteus, a sysegnaya stick, staphylococci, enterococci, klebseyll, intestinal sticks) 10 ml on the bottle.

Also, the preparation includes auxiliary substances - preservatives.

Form release

The solution in a bottle of 20 ml, ampoules of 10 and 5 ml. In the carton 4 bottles, ampoules - 5 or 10 pieces.

pharmachologic effect

Antibacterial, immunostimulating agent.

Pharmacodynamics and pharmacokinetics

The drug specifically lishes the bacteria of the protea, streptococci, staphylococci, Klebsiell pneumonia, and a cinema stick, various serogroups of the echryochi. Thus, having an immunostimulating effect on the body.

Indications for use

Liquid piobacteriophage prescribe:

for the treatment and prevention of purulent, inflammatory, gastrointestinal diseases;
with peritonitis, pleurite, osteomyelitis, mastitis, purulent wounds and lesions of the skin;
for the treatment of Angine, Stomatitis, Otitis, Schimorita, pleurrites and pneumonia;
with pancreatitis, gastroenterocolite, cholecystitis, dysbacteriosis;
for the treatment of cystitis, endometritis, collision, pyelonephritis;
with corneal suppurations, conjunctivitis;
with ommopalites, pyoderms, enteritis, various dysbidity, septicemia, septicopemia.

Contraindications

Has no.

Side effects

Not registered.

Instructions on Piobacteriophage Polyvalent Purified (Method and Dosage)

According to the instructions for the use of piobacteriophage polyvalent, with the drug makes enemas, grafting and irrigation to the means. It is also possible to use the drug is intramilly and inside.

The frequency of application is 1-3 times a day. The course, as a rule, ranges from 5 to 15 days.

For the treatment of pyelonephritis are prescribed inside 5-20 ml, 3 receptions.

How to give a child?

When manifesting indomitable vomiting in children up to a year, you can additionally enter the means through the probe, 3-5 ml every day. The course is 5-7 days.

For the treatment of enemmalites and pyoderms, the newborn medicine can be applied in the form of applications, twice a day. The course of the pureolivalent bacteriophage is from 5 days before the week.

Overdose

No overdose cases are registered.

Interaction

In parallel with the treatment of the drug, other anti-inflammatory and antibacterial agents can be used.

Terms of sale

The recipe is not needed.

Storage conditions

Temperature from 2 to 8 degrees. The shelf life at a temperature of up to 25 degrees is reduced to one month. Use immediately after opening. When flakes, heterogeneity of the solution, after the expiration date, it is impossible to use bacteriophages.

Shelf life

24 months.

Analogs

Analogs: Piobacteriophage, Piopacteriophage complex liquid, piopolyag, sextapag.

Complex bacteriophage and polyvalent piobacteriophage

The only difference in complex piobacteriophage and is polivalent to the fact that enterococcus phagolisate is not contained in the latter. Preparations have a common manufacturer.

Reviews on Piobacteriophage Polyvalent Purified

Reviews of doctors are good. It is also used by surgeons for postoperative processing of wounds, and pediatricians, and gynecologists with urologists. Some believe that the drug is more efficient and safe to use than antibiotics.

Reviews on forums are very good. Many used the drug and remained satisfied. Bacteriophage is particularly effective for children, due to the lack of side effects, often the newborn is allergic to antibiotics.

Price of polyvalent piobacteriophage where to buy

The price of piobacteriophage polyvalent purified in Ufa is about 650 rubles.

To buy a tool in Moscow for 700 rubles, for 4 ampoules of 20 ml. Sometimes the means may be called pure polyvalent bacteriophage.

NOTE! Information about drugs on the site is a reference and generalizing, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medicines in the course of treatment. Before applying the drug, polyvalent piobacteriophage must be consulted with the attending physician.

mEDSIDE.ru.

Bacteriophage comprehensive: instructions for use, analogues and reviews

Diseases of bacterial etiologists are most often treated with antibacterial drugs that have a wide range of action. For selective destruction of pathogens, bacteriophages are recommended. Such drugs have many advantages over other medicines. The bacteriophage complex is a drug, which consists of several types of bacteriophages at once. Consider a Read more Mechanism of action and the scope of this medicine.

What is bacteriophages?

Each disease needs specific treatment. To find the right method of therapy, it is important to determine the type of pathogen. To combat bacterial pathologies, which are characterized by severe flow and consequences, doctors often prescribe bacteriophages. These drugs are viruses beneficial to the human body that use malicious bacteria for breeding and continuing their livelihoods. At the same time, they have a negative impact only on pathogenic microorganisms and do not affect the operation of organs and systems.

In contrast to antibiotics, bacteriophages do not destroy the useful microflora and do not cause the development of dysbiosis. Preparations can be taken on a long-term basis and not be afraid of the emergence of resistance of pathogenic microorganisms to the current components.

In pediatric practice, bacteriophages are often applied. Feedback (children are prescribed after diagnosis) specialists confirm the effectiveness of the drug under the condition of accurate determination of the type of pathogen. For this, before starting therapy, it is necessary to undergo laboratory diagnostics. Bacteriophages are considered as powerful preparations as antibiotics.

Antibacterial drug

Active substance

Piobacteriophage

Release form, composition and packaging

Preservative: Hinosol 0.0001 g / ml

10 ml - glass bottles (4) - cardboard packs.
10 ml - glass bottles (10) - cardboard packs.
10 ml - glass vials (4) - Packaging Cell contour (1) - packs cardboard.

20 ml - glass bottles (4) - cardboard packs.
20 ml - glass bottles (10) - cardboard packs.
20 ml - Glass vials (4) - Packaging Cell Contour (1) - Cardboard packs.

pharmachologic effect

The drug has the ability to specifically lyse bacteria Staphylococcus, Streptococcus, Proteus, Pseudomonas Aeruginosa, Klebsiella Pneumoniae, Escherichia Coli.

Indications

Treatment and prevention of various forms of purulent-inflammatory and enteral diseases caused by bacteria Staphylococcus, Streptococcus, Proteus, Pseudomonas Aeruginosa, Klebsiella Pneumoniae, Escherichia Coli:

gastrointestinal diseases (gastroenterocolite, cholecystitis, intestinal dysbiosis);
inflammatory diseases of newborns and young children (gastroenterocolitis, intestinal dysbacteriosis, ommopalitis, pemphigus, pyodermia, septicemia and septicopyiamia of various localization);
surgical infections (wound suppurations, purulent lesions of the skin, burns, peritonitis, pleurisit, mastitis, osteomyelitis);
urogenital infections (cystitis, pyelonephritis, endometritis, vulvit, bartolinite, colpit, salpingo-phorite);
purulent-inflammatory, throat, nose, nose sinuses, oral cavity, pharynx, larynx, lungs and pleura (otitis, angina, pharyngitis, stomatitis, periodontitis, sinusitis, frontititis, pneumonia, pleurisy);
post-stramatic, keratoconjunctivitis, purulent corneal and iridocyclite ulcers;
prevention of nosocomial infections caused by bacteria Staphylococcus, Streptococcus, Proteus, Pseudomonas Aeruginosa, Klebsiella Pneumoniae, Escherichia Coli.

An important condition for effective phagening therapy is the preliminary definition of the phagezensitivity of the pathogen.

Contraindications

No missing.

Dosage

Before using the bottle with bacteriophage, you must shake and view. The drug must be transparent and do not contain a sediment.

Attention! When clouding, the drug does not apply!

wash your hands thoroughly;
handle the cap with alcohol-containing solution; Remove the cap without opening the plugs;
do not put the plug in the inner surface on the table or other items;
do not leave the bottle open;
opened bottle to store only in the refrigerator.

When using small doses (2-8 drops), the drug must be selected with a sterile syringe in a volume of 0.5-1 ml.

The drug from the opened vial while complying with the storage conditions, the above rules and the absence of turbidity can be used during the entire expiration date.

Inside the drug take on an empty stomach for 0.5-1 hours before meals.

The treatment of purulent-inflammatory diseases with localized lesions should be carried out simultaneously both locally and the drug intake.

In the case of processing the cavity of the purulent focus, chemical antiseptics before using the bacteriophage, it must be a sterile with a sterile 0.9% solution.

For treatment of angina, pharyngitis, laryngitis The drug is used for rinsing of the oral cavity and pharynx 3 times a day at 10-20 ml, the course of treatment is 7-10 days.

For treatment, pneumonia The drug is taken inward 3 times a day at 10-20 ml, and also used in the form of aerosols and inhalations (without heating and use of ultrasound), a course of treatment for 15-20 days.

For treatment The drug is used for washing and administering to the cavity of the middle ear 2-5 ml 1-3 times a day. Course of treatment 7-15 days.

For treatment of inflammation of the sinuses of the nose The drug is used to wash the nasal cavity, nasopharynx and nasal sinuses at a dose of 5-10 ml and administration to the sinuses 2-3 ml. The procedure is repeated daily once for 7-10 days. In addition, the drug is introduced into the nasal cavity in the form of turf moistened with bacteriophage, in turn in each nasal stroke and leave for 0.5-1 hours. The procedure is repeated 3 times a day, the course of treatment is 7-15 days.

For treatment of stomatitis and chronic periodontitis The drug is used in the form of rinsing of the oral cavity 3-4 times a day at a dose of 10-20 ml, as well as to the administration of Turund impregnated with bacteriophage into paradontal pockets, 5-10 minutes, 7-10 days treatment.

For conjunctivitis and keratoconjunctivitis The drug is used for 2-3 drops 4-5 times a day, the course of treatment is 5-7 days; for purulent ulcer corneal - 4-5 drops a day for 7-10 days, with purulent iridocyclite - 6-8 drops every 3 hours in combination with a reception inside in therapeutic dosages for 7-10 days.

For abscessafter opening and removing the purulent content, the drug is administered in the amount of less than the volume of remote pus daily once, the course of treatment is 7-10 days.

For peritonitte and pleurite The drug is introduced into drained cavities - abdominal and pleural through drainage tubes daily once 20-70 ml, the course of treatment is 10-15 days.

For osteomyelitis The drug is introduced into the cavity of the wound through Turundas, drainage in the amount of 10-30 ml daily once, the course of treatment is 15-20 days.

For treatment of mastitis, joining wounds and burnsThe drug is used in the form of irrigation, applications, bandages, introducing into drainage at a dose of 5-50 ml, depending on the lesion focus at least 1 time per day, the course of treatment is 10-15 days.

For treatment of purulent-inflammatory gynecological diseases (Nudencies of the Russian Academy of Sciences, Endometritis, Vulvit, Bartolynitis, Colport, SalpingOforita) The drug is used for irrigation, applications, injected into the cavity of wounds, vagina, uterine 5-20 ml once a day for 7-10 days.

For cystitis, pyelonephritis, urethritis The drug is taken inward in the therapeutic dose 3 times a day 1 hour before meals for 10-20 days. In that case, if the cavity of the bladder or renal izhanki is drained, the drug is administered through cystomate or nephrostable 1-3 times a day at 20-50 ml in the bladder and 5-7 ml into the renal loin, the course of treatment is 7-15 days.

For gastroenterocolite, pancreatitis, cholecystitis, as well as intestinal dysbiosis Bacteriophages take inside in age dosages 3 times a day 1 hour before meals for 7-15 days (under clinical indications). In case of indoorable vita, the drug is used in the form of high enema 2-3 times a day at 20-40 ml. In the intestinal dysbiosis, the drug can be used with normoflore preparations.

For Prevention of nosocomial surgical infections The drug is used to handle postoperative and freshly infected wounds in a dose of 5-50 ml, depending on the lesion, one day once every 5-7 days.

Application of drug in children under 1 (including premature babies)

For gastroenterocolite, pneumonia and sepsis of newborns The drug is used through the mouth 2-3 times a day at 3-5 ml 30 minutes before feeding. In cases of indomitable vomiting, the drug is used in the form of high enema (through a gas-conductive tube or catheter) daily once in a dose of 5-10 ml. Perhaps the combination of rectal (in the form of high enema) and oral administration of the drug. Course of treatment for 7-15 days (under clinical indications). With the recurrent course of the disease, it is possible to re-conduct treatment courses.

For treatment of ommopalitis, pyodermia infected with wounds Bacteriophages are used in the form of applications at 5-10 ml 2-3 times a day (the gauze napkin is wetted by bacteriophage and impose on the umbilical wound or affected area) within 7-15 days.

Conditions of vacation from pharmacies

Without recipe.

Terms and Storage Terms

The drug is stored (in an inaccessible place for children) and transported in accordance with the joint venture 3.3.2.1248-03 at a temperature of from 2 to 8 ° C. It is allowed at a temperature of from 8 to 25 ° C for no more than 1 month. Shelf life - 2 years.