Antispasmodic drugs are widely used to dilate blood vessels and relieve spasms of smooth muscles of organs. Which is better - Drotaverine or No-shpa? This question is of interest to many patients who want to know why doctors prescribe more often. The action of both drugs is aimed at eliminating spasms and pain. In this case, both drugs have the same dosage of the active drug substance drotaverine. But these medicines have some differences that every person needs to know.
Drotaverine and Nosh-pa - comparative characteristics
Spasmolytics eliminate spasms of various internal organs and help to quickly eliminate pain. Pain in the abdomen can be caused by a pathological process - inflammation in the biliary tract, cystitis, infection of the gastrointestinal tract.
Spasms cause irritable bowel syndrome, enteritis, ulcers, cholecystitis. For many pregnant women, doctors prescribe antispasmodic drugs to restore uterine tone and prevent miscarriage. A table that clearly shows the characteristics of both medicines will help you understand the features of both drugs.
| Options | Drotaverine | No-shpa |
| Medical group | Spasmolytics |
|
| Form of production | Capsules, injection solutions. |
|
| The main effective substances in the composition | Drotaverine (40 mg), lactose, povidone, crospovidone | Drotaverine (40 mg), lactose, povidone, starch |
| Indications for use | - vasospasm, - pyelitis, intestinal colic, stomach ulcer, Cholecystitis, cholelithiasis, Gastritis, gallbladder disease, Cholelithiasis, menstrual pain Spastic colitis. | - pain relief and spasm relief, - colitis, Diseases of the stomach and gastrointestinal tract, Headache, Gastritis, bladder ailments, Urolithiasis disease, papillitis, Colic in liver and stomach. |
| Contraindications |
|
|
| Side effects with errors in application and dosage | - digestive disorders, - stool disorders, Dizziness, Headache, Insomnia, Allergy. | - disorders of the stool, - disorders of the digestive organs, Headache, dizziness, vision disorders, Allergic rash. |
| Safety for the whole body | Safely | Safely |
| Prevention of liver diseases | By doctor's prescription |
|
| Course of therapy | ||
| An analogue of the drug, with a stronger effect. | Bioshpu, Ple-Spa, Nosh-bra, Nikoverin, Spazoverin, Spazmonet, Spazmol | Nosh-bra, Spazmol, Spazoverin, Vero-Drotaverin |
| Manufacturer | Russia | Hungary |
| Average price | Tablets 80 mg 20 pieces - 60 rubles, for 10 ampoules of 2 ml - 58 rubles | Tablets 40 mg 6 pieces - 69 rubles, for ampoules of 2 ml - 90 - 160 rubles |
Antispasmodic drugs are prescribed to eliminate spasms of smooth muscles. During pregnancy, it is prescribed for the relief of pain and with the threat of miscarriage, but only in special cases to remove high risks. Drotaverine is also shown with a strong cough to relieve spasm, headache and menstrual pain. During bronchospasm, the medicine helps to relieve a painful attack and restore breathing.
Good to know Drotaverine is used to relieve pain and spasms. He is not involved in the process of eliminating the cause of the disease. In some cases, doctors recommend taking Drotaverine or Noshpa to calm down before going to bed. The drug can be used in extreme heat. Which is better - Drotaverine or Noshpa? Doctors prefer to prescribe the imported drug Noshpa, relying on its safer effect.
Differences between the two drugs
In terms of their effects and properties, both drugs are almost identical. Despite similar pharmacological properties, the drugs have the following differences:
- Manufacturer. No-shpa is produced by a well-known Hungarian company, while Drotaverin is a Russian counterpart.
- Drotaverine contains crospovidone.
- Large doses of Drotaverine can cause disturbances in cardiac activity and even cardiac arrest. Noshpa is safer to use.
- Drotaverine can be taken by children from 3 years of age. Noshpa is recommended for use from 5-6 years.
- Drotaverine has a cheaper cost than the imported drug Noshpa.
Important! The use of the substance drotaverine can be dangerous with low blood pressure and hypotension. Both drugs lower blood pressure and have a vasodilating effect. Drotaverine can be taken during a hypertensive crisis to lower blood pressure. Injections of Noshpa and Drotaverin are prescribed in extreme cases, when swallowing a tablet is impossible for some reason.
Common features of the two drugs
What is better Drotaverine or Noshpa? Drotaverine is an analogue of the more expensive imported medicine No-shpy. Both products contain the same amount of active drug substance. The drugs are almost identical in their pharmacological properties. Their action is aimed at eliminating spasms and pain. Medicines do not disrupt the functions of the central nervous system, relax smooth muscles and soothe. Intravenous or intramuscular injections can disrupt the patient's psychomotor.
Gross formula
C 24 H 31 NO 4Pharmacological group of the substance Drotaverine
Nosological classification (ICD-10)
CAS code
14009-24-6Characteristics of the substance Drotaverine
Light yellow crystalline powder, odorless. Soluble in water and alcohol.
Pharmacology
pharmachologic effect- vasodilator, antispasmodic, myotropic, hypotensive.Reduces the flow of ionized active calcium into smooth muscle cells by inhibiting phosphodiesterase and intracellular accumulation of cAMP. Quickly and completely absorbed in the digestive tract. When administered orally, the bioavailability is close to 100%, and the half-life is 12 minutes. It is evenly distributed over tissues, penetrates into smooth muscle cells. Excreted by the kidneys.
Pronounced and long-term expands the smooth muscles of internal organs and blood vessels, lowers blood pressure, increases the cardiac output. It practically does not affect the autonomic nervous system and does not penetrate the central nervous system.
Application of the substance Drotaverine
Spasm of smooth muscles of internal organs (cardio- and pylorospasm), chronic gastroduodenitis, peptic ulcer of the stomach and duodenum, cholelithiasis (hepatic colic), chronic cholecystitis, postcholecystectomy syndrome, hypermotor biliary dyskinesia, spastic intestinal dyskinesia, intestinal colic due to gas retention after operations, colitis, proctitis, tenesmus, flatulence, urolithiasis (renal colic), pyelitis, spasm of cerebral vessels, coronary and peripheral arteries, the need to weaken uterine contractions and relieve cervical spasm during childbirth, spasm of smooth muscles during instrumental interventions.
Contraindications
Hypersensitivity, glaucoma.
Application restrictions
Prostate adenoma, severe atherosclerosis of the coronary arteries.
Use during pregnancy and lactation
Side effects of the substance Drotaverine
Feeling of heat, dizziness, arrhythmias, hypotension, palpitations, sweating (more often with parenteral administration), allergic dermatitis.
Interaction
Enhances (especially when administered intravenously) the effect of other antispasmodics (including m-anticholinergics), hypotension caused by tricyclic antidepressants, quinidine, procainamide. The reliability of spasm elimination increases phenobarbital. Reduces spasmogenic activity of morphine, antiparkinsonian properties of levodopa.
Overdose
AV blockade, cardiac arrest, paralysis of the respiratory center.
Routes of administration
Inside, in / m, p / c.
Interactions with other active substances
Trade names
| Name | The value of the Wyshkovsky Index ® |
| 0.3402 | |
| 0.0181 | |
| 0.0097 | |
| 0.0029 | |
| 0.0021 | |
| 0.0021 | |
| 0.0019 | |
| 0.0009 | |
| 0.0009 | |
| 0.0008 | |
"Drotaverine" is a well-known antispasmodic, which adults often use for cholecystitis, intestinal colic, urolithiasis and other problems, to get rid of which you need to eliminate spasm of smooth muscles. Not everyone knows whether such a medicine is used in childhood, when the medicine is prescribed to children and how it affects the child's body.
Release form
"Drotaverin" is produced by:
- In tablets which are taken internally. They are distinguished by a yellow-greenish color and a flat round shape. One pack contains from 10 to 100 tablets.
- in solution for injections. It is represented by a transparent yellow or greenish-yellow liquid, poured into dark glass ampoules of 2 or 4 ml. One box sells 5, 10 or 20 ampoules.
In addition, the drug can be produced with a slightly changed name - for example, "Drotaverin-UBF", "Drotaverin-Ellara" or "Drotaverin-Teva". At the same time, such drugs include the same active compound, are also produced in tablets and solution, and the dosage of the active ingredient, as well as the indications, other features of the application, they are the same. Additional letters or words in the name only indicate the pharmaceutical company that manufactures this version of Drotaverin.
Compound
The active component of any form of the drug is drotaverine hydrochloride. One tablet usually contains 40 mg of such a compound, but Drotaverin Forte is also available with a dosage of 80 mg per 1 tablet. One milliliter of the injectable form may contain either 10 or 20 mg of the active ingredient.
Among the excipients in tablet form, you can see talc, potato starch, povidone, lactose monohydrate and other components (depending on the manufacturer). In addition to drotaverine and sterile water, sodium disulfite, as well as ethyl alcohol, acetic acid, sodium metabisulfite or sodium acetate trihydrate may be present in the injection solution.
Operating principle
Drotaverine has the ability to relax smooth muscles, which are located in the walls of blood vessels and in internal organs, so the drug eliminates spasms (which also helps to get rid of pain caused by spasms) and dilates blood vessels, while lowering blood pressure.
The drug acts most effectively on smooth muscles in the gastrointestinal tract, urinary organs and biliary tract. This leads to a decrease in pain and discomfort caused by increased tone or spasm in such organs. "Drotaverine" is considered an effective analgesic for various functional disorders and diseases of the gastrointestinal tract, gallbladder, bladder and kidneys.
Due to the vasodilating effect of the drug, microcirculation improves, that is, more nutrients and oxygen enter the tissues. Since Drotaverin does not have a sedative effect, it can be used in situations where M-anticholinergics cannot be given (for example, with angle-closure glaucoma).
Indications
"Drotaverine" is prescribed both in the presence of pain and functional disorders in the functioning of internal organs due to spasm of smooth muscles, and in order to prevent such problems.
The medicine is used:
- With abdominal pain caused by spastic constipation, gastritis, pylorospasm, intestinal colic, enteritis, flatulence and other lesions of the gastrointestinal tract.
- With hepatic colic, biliary dyskinesia, cholangitis and other diseases of the biliary tract.
- With cystitis, spasms of the bladder, pyelitis, renal colic and other pathologies of the urinary system.
- For headaches.
- With vasospasm (at high temperature).
- During examinations during which a medical instrument is inserted into the body (for example, during gastroscopy).
- With a strong dry cough caused by bronchospasm or laryngotracheitis. Although such an indication is not noted in the official instructions, many doctors note the effect of "Drotaverine" on the bronchi, so they recommend drinking the drug at night so that the child does not suffer from coughing and sleeps peacefully.
The injection form of the drug is prescribed in exceptional cases and only in an acute condition in order to help the child as soon as possible. As soon as the spasm is removed, they switch to the use of tablets. In addition, Drotaverine injections are prescribed if it is impossible to give tablets to a small patient.
At what age is it allowed to take?
Drotaverine tablets are prescribed from the age of 3, and injections are prescribed for children over 1 year old. Age restrictions in the use of the tablet form are associated only with the difficulties of children under 3 years of age with swallowing a solid drug. If the baby knows how to swallow a pill, this form can also be used at the age of over a year.
Contraindications
The medicine is not prescribed:
- With individual sensitivity to any component of the solution or tablets.
- With severe renal failure.
- With heart failure.
- With serious pathologies of the liver.
- With hypotension.
- With atrioventricular blockade.
If the child has angle-closure glaucoma, the use should be supervised by a doctor. Adults do not prescribe the drug during breastfeeding and in the first trimester of pregnancy.
Side effects
When treated with Drotaverin, insomnia, dizziness, nausea, arrhythmia, increased sweating, lowering blood pressure, vomiting, an allergic reaction, feeling hot, constipation and other negative symptoms may occur. When they appear, you should immediately tell your doctor about such reactions.
Instructions for use and dosage
Tablets
The drug in this form is taken after a meal. The drug should be swallowed whole, not chewed or crushed into powder. To drink the medicine, use clean water in a small amount.
The dose of such a remedy depends on the age of the small patient:
- A child of 3-6 years old (for example, at 4 years old) is given 1/4-1/2 tablets (10-20 mg of Drotaverine). Taking the drug in this dosage is prescribed twice or thrice a day, and the maximum dose for a child of 5 years and other babies of this age is 3 tablets (120 mg of the active compound).
- A child of 6-12 years old is prescribed from 20 to 40 mg of Drotaverin at one time, which corresponds to half or a whole tablet. The drug is given from two to five times a day, and 5 tablets (200 mg of Drotaverine) are called the permissible maximum.
- A teenager over the age of 12 years old is given 40-80 mg of Drotaverine (1-2 tablets) for 1 dose. The drug is taken 2-3 times a day, and the maximum dose at this age is 6 tablets (240 mg of the active ingredient).
The duration of treatment with tablets usually does not exceed 1-2 weeks and is determined by the doctor individually.
Injections
"Drotaverine" in injections can be injected into a muscle, into a vein or under the skin. With colic, the solution is most often administered intravenously. If the patient has a spasm of peripheral vessels, the introduction of the drug into the artery is also possible. In other cases, subcutaneous and intramuscular injections are used.
The drug is administered 1-3 times a day. The dose of the drug, as for tablets, is determined by age:
- A child 1 year old, 2 years old and older (up to 6 years of age) takes 0.5-1 ml of medication for one injection, since a single dose for this age is 10-20 mg of Drotaverine.
- Children 6-12 years old are prescribed 20 mg of active compound per dose, which corresponds to 1 ml of solution.
- A child over 12 years of age takes 1-2 ampoules of the drug for one injection.
The maximum daily dosage of the drug is the same as for the tablet form. With intravenous injection, the child must lie down so that the injection does not cause collapse. The ampoule for such injections is diluted with glucose or saline (10-20 ml), and the administration itself is performed very slowly. For injections under the skin or into muscle tissue, it is not necessary to dilute Drotaverine.
Overdose
If you exceed the dose of the drug, it will adversely affect the work of the heart and may interfere with breathing. In such a situation, you should immediately consult a doctor.
Interaction with other drugs
Drotaverine has the ability to enhance the therapeutic effect of other antispasmodics and weaken the effect of levodopa. When used together with Phenobarbital, the antispasmodic effect of Drotaverine is enhanced.
At elevated temperatures, "Drotaverine" is often included in the composition of the lytic mixture, which includes "Analgin" (It can be replaced by "Paracetamol") and "Diphenhydramine" (or "Suprastin"). In this combination, the drugs effectively fight white fever.
Terms of sale
Drotaverine tablets are an over-the-counter remedy, and you need a prescription from a doctor to buy ampoules.
Storage conditions and shelf life
To store the medicine, a dry place hidden from sunlight is required, where the temperature will not exceed +25 degrees. You need to keep the drug at home where a small child cannot get it. The shelf life of both tablets and solution is 3 years.
Thanks
The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!
Drotaverine represents antispasmodic, relaxing the smooth muscles of the internal organs and thereby stopping spastic pain, reducing the intensity of intestinal peristalsis, vasodilating and depressurizing. Drotaverine is usually used to reduce the tone or relieve spasm of the smooth muscles of the internal organs, for example, with cholecystitis, threatened miscarriage, hepatic colic, biliary dyskinesia, urolithiasis, cystitis, pyelitis, gastritis, gastroduodenitis, intestinal colic, pain during menstruation, spastic colitis and etc. In addition, Drotaverine is used to eliminate spasm of the cervix and weaken uterine contractions during childbirth.Varieties, names, composition and forms of release
Currently, several varieties of Drotaverine are produced under the following names:- Vero-Drotaverine;
- Drotaverine;
- Drotaverin MS;
- Drotaverin-Teva;
- Drotaverin-UBF;
- Drotaverine-FPO;
- Drotaverine Forte;
- Drotaverine-Ellara.
All varieties of the drug are usually combined under the general name "Drotaverine". In the further text of the article, we will also use this name, meaning by it all varieties of Drotaverine, and only if necessary we will indicate the exact and full name.
Drotaverine is available in two dosage forms - oral tablets and injection. As an active substance, all varieties of Drotaverine contain drotaverine hydrochloride in the same dosage. So, Drotaverine tablets contain 40 mg of the active substance, and the solution - 10 mg / ml or 20 mg / ml. Drotaverin Forte tablets contain 80 mg of the active substance.
Excipients in each variety of Drotaverine may be different, since their composition is determined by the production technology adopted at a particular pharmaceutical enterprise. Therefore, to clarify the composition of the auxiliary components, you need to read the package leaflet with instructions attached to this particular drug.
Drotaverine and No-shpa - what's the difference?
No-shpa and Drotaverine are synonymous drugs, that is, they contain the same active ingredient. However, despite the apparent identity, there is a difference between the drugs. So, No-shpa is an original drug, the active substance for which is produced under careful control and undergoes excellent purification from impurities. Due to the high purity of the active substance, No-shpa is highly effective and has a minimal risk of side effects.The active substance for varieties of Drotaverine is not produced by the pharmaceutical factories themselves, but is purchased from large chemical laboratories in China and India. Naturally, the degree of its purification is much worse than that of the active component of No-shpa, as a result of which the effectiveness of Drotaverine is lower, and side effects develop more often and are worse tolerated.
That is, the difference between Drotaverine and No-shpa lies in the quality of the same chemical that is part of them, which is much higher in No-shpa. Therefore, many are faced with the situation that in the same case, Drotaverine is ineffective, and No-shpa copes with the task.
What helps Drotaverine (action)
Drotaverine is a myotropic antispasmodic, has antispasmodic, myotropic, vasodilating and antihypertensive effects. All these effects are provided by the ability of Drotaverine to relax the smooth muscles of the internal organs and blood vessels, due to which spasms and associated pains are stopped, the lumen of the vessels expands and blood pressure decreases. Drotaverin most powerfully relaxes the smooth muscles of the gastrointestinal tract, biliary tract and genitourinary system. Due to this, the drug relieves pain and various discomforts caused by spasm or increased muscle tone of these organs, for example, during menstruation, cholecystitis, gastritis, intestinal or renal colic, etc. In other words, Drotaverine is effective anesthetic drug with almost any diseases and functional disorders of the gastrointestinal tract, genitourinary system and biliary tract.
The antihypertensive effect of Drotaverine is due to the fact that the muscles of the vessels also relax, due to which their lumen expands. The vasodilating effect of the drug leads to an improvement in microcirculation and, accordingly, tissues are better supplied with oxygen and nutrients.
6. In obstetric and gynecological practice for:
- Elimination of the threat of miscarriage;
- Elimination of the threat of premature birth;
- Spasm of the pharynx of the uterus during childbirth;
- Protracted opening of the cervix during labor pains;
- Afterpains.
Instructions for use
Instructions for use of Drotaverine tablets
Drotaverine tablets should be taken orally immediately after a meal, swallowing them whole, without biting, chewing or crushing in other ways, but with a small amount of water. The need to take the drug after a meal does not mean that you need to fully eat every time before taking the pill. It is enough to eat an apple, banana, sandwich or any other food in a small amount, and then take a pill. For various diseases and conditions, Drotaverine is taken in the same age-appropriate dosages. So, depending on age, Drotaverine is recommended to be taken in the following dosages:
- Children aged 3 - 6 years - take 10 - 20 mg (a quarter or half a tablet) 2 - 3 times a day (the maximum daily dosage for children 3 - 6 years old is 120 mg (3 tablets), divided into 2 - 3 doses);
- Children aged 6 – 12 years - take 20 - 40 mg (1/2 - 1 tablet) 2 - 5 times a day (the maximum daily dosage for children of this age is 200 mg (5 tablets), divided into 2 - 5 doses);
- Teenagers over 12 and adults - take 40 - 80 mg (1 - 2 tablets) 2 - 3 times a day (the maximum daily dosage for this age group is 240 mg (6 tablets), divided into 2 - 4 doses).
Drotaverine ampoules - instructions
Drotaverine solution for both children and adults can be administered intramuscularly, intravenously, subcutaneously or intra-arterially. To stop renal or hepatic colic, the solution is administered intravenously, with spasms of peripheral vessels - intra-arterially, and in all other cases - intramuscularly or subcutaneously. Adults and teenagers over 12 years old under various conditions, 40-80 mg (1-2 ampoules) of the solution are administered 1-3 times a day in the necessary way (intravenously, intramuscularly, etc.). The maximum allowable daily dosage of the solution for adults and adolescents over 12 years of age is 240 mg, which is equivalent to 6 ampoules.
For children, the solution is administered in the following smaller dosages, depending on age:
- Children 1 – 6 years old- administer 10 - 20 mg (0.5 - 1 ml of solution) 1 - 3 times a day. During the day, you can enter a maximum of 120 mg of Drotaverine (3 ampoules);
- Children 6 – 12 years old- administer 20 mg (1 ml of solution) 1 to 3 times a day. During the day, you can enter a maximum of 200 mg Drotaverine (5 ampoules).
To accelerate the opening of the cervix, Drotaverine is administered intramuscularly once at a dosage of 40 mg (1 ampoule). If the effect is insufficient, then after 2 hours the Drotaverine solution is administered again.
For pain against the background of exacerbation of gastric ulcer or duodenal ulcer, Drotaverine is recommended to be combined with atropine or belladonna preparations.
special instructions
It must be remembered that Drotaverine solution should be used only in acute conditions or when it is impossible to drink tablets. As soon as the acute condition is removed or the person can swallow the tablets, the injection of the drug should be stopped and the drug should be taken orally.Drotaverine can be used in the complex therapy of hypertensive crisis.
Since the tablets contain lactose, they are not recommended for people suffering from lactase deficiency, galactosemia, glucose / galactose malabsorption syndrome.
Influence on the ability to control mechanisms
Tablets do not worsen the state of the central nervous system, therefore, while taking them, you can engage in any type of activity that requires a high speed of reactions and concentration.Injection may impair the speed of psychomotor reactions, therefore, within an hour after each injection, one should refrain from engaging in potentially hazardous activities that require a high concentration of attention. An hour after the injection, you can engage in any kind of activity.
Overdose with Drotaverine
An overdose of Drotaverine is possible and is manifested by the following symptoms:- Violation of the conduction of the heart;
- Deterioration of the excitability of the heart muscle;
- Paralysis of the respiratory center.
Interaction with other medicinal substances
Drotaverine enhances the effect of other antispasmodics - Papaverine, Atropine, Bendazol, Buscopan, Halidor, etc.Drotaverine enhances the reduction in blood pressure caused by Quinidine, Novocainamide and tricyclic antidepressants (Amitriptyline, Clomipramine, Imipramine, etc.).
Phenobarbital enhances the effect of Drotaverine on the relief of spasms.
Drotaverine reduces the ability of morphine to provoke spasms of internal organs.
Drotaverine weakens the effect of Levodopa and Carbidopa.
Drotaverine for children
Drotaverine is approved for use in young children. The solution can be administered to children from one year old, and tablets can be given from 3 years old. The ban on the use of Drotaverine tablets for children under 3 years of age is due to the fact that babies still do not know how to swallow them and can choke. There are no other barriers to the use of Drotaverine tablets by children under 3 years of age. Therefore, in principle, tablets can also be used from the age of one, but only if the child has learned to swallow them, and the risk of suppression is minimal.For children of any age, it is better to give Drotaverine in the form of tablets, and not to inject. Any injection of the drug should be made only in case of emergency, when you can not drink a pill.
Dosages Drotaverine are the same under various conditions and make up the following values for children of different ages:
- Children aged 1 - 6 years - 10 - 20 mg (1/4 - 1/2 tablets or 0.5 - 1 ml of solution) 2 - 3 times a day (the maximum daily dosage for children 3 - 6 years old is 120 mg (3 tablets or 3 ampoules) divided into 2 - 3 doses);
- Children aged 6 – 12 years - 20 - 40 mg (1/2 - 1 tablet, 1 - 2 ml of solution) 2 - 5 times a day (the maximum daily dosage for children of this age is 200 mg (5 tablets or 5 ampoules), divided into 2 - 5 receptions);
- Teenagers over 12 years old - 40 - 80 mg (1 - 2 tablets or 2 - 4 ml of solution) 2 - 3 times a day (the maximum daily dosage for this age group is 240 mg (6 tablets or 6 ampoules), divided into 2 - 4 doses ).
Drotaverine in children is used to relieve pain in cystitis, gastritis, flatulence, intestinal colic, constipation, and also to alleviate the condition at high temperature. Quite often, at a temperature, children are prescribed Drotaverine with antipyretic drugs (Paracetamol, Ibuprofen, Nimesulide, etc.), since it dilates blood vessels and contributes to a more rapid decrease in body temperature.
In addition, quite often Drotaverine is prescribed to children with laryngotracheitis and bronchospasm, when the child coughs painfully, tearing his throat. Although the effect of the drug on the bronchi has not been proven, however, its use in bronchospasm often turns out to be effective, the child stops coughing and his general condition improves. Therefore, despite the absence of this item in the indications for use in official instructions, Drotaverine is quite successfully used as an emergency remedy for bronchospasm and painful dry cough. In such situations, doctors recommend giving the child Drotaverine at night so that he can sleep peacefully without suffering from a cough.
Application during pregnancy
Drotaverine does not adversely affect the fetus and the course of pregnancy, so the drug can be used throughout the entire period of bearing a child. However, Drotaverine should not be considered a completely and completely safe drug for pregnant women, since they simply do not exist, and any medicine carries a potential danger. Therefore, during pregnancy, Drotaverine should be used only if the benefits outweigh all the risks and harms. For pregnant women, Drotaverine is usually prescribed for the threat of miscarriage or premature birth, as well as for the relief of pain caused by contractions and stretching of the growing uterus. The drug has proven itself and is used very widely. Many women fear that under the influence of Drotaverine, childbirth will have to be induced, since labor activity will not begin on its own. However, such fear is unfounded. Pregnant women should take the drug at the usual adult dosages.
Papaverine and Drotaverine
Both Papaverine and Drotaverine are drugs of the same group - antispasmodics, that is, they act in approximately the same way. However, Drotaverine is more effective and safer than Papaverine, which, despite obsolescence, continues to be prescribed and used as an "old and proven" remedy.Papaverine relieves acute spasms better, but in chronic conditions or diseases, its effectiveness is much lower than that of Drotaverine. Therefore, we can say that Papaverine is better to use in acute conditions, and Drotaverine - for long-term course therapy of chronic diseases.
Side effects
Tablets and injections of Drotaverine can cause the following side effects: - Headache;
- Dizziness;, renal or heart failure;
- Atrioventricular block II-III degree;
- Cardiogenic shock;
- Hypotension (low blood pressure);
- Age under 1 year (only for tablets).
- Severe atherosclerosis of the cardiac arteries;
- Angle-closure glaucoma;
- Pregnancy and the period of breastfeeding.
Drotaverine: instructions for use and dosage, therapeutic effect, form of release, side effects, contraindications - video
Analogues
Drotaverin has two types of analogues - synonyms and, in fact, analogues. Synonyms are drugs that, like Drotaverine, contain drotaverine hydrochloride as an active substance. Analogues are preparations containing other active ingredients, but having the most similar spectrum of therapeutic activity (other antispasmodics). So, to the synonyms of Drotaverine include the following drugs:
- Bioshpa tablets;
- No-shpa tablets and solution for injection;
- No-shpa Forte tablets;
- Nosh-Bra tablets and solution for injection;
- Ple-Spa tablets;
- Spasmol tablets and solution for injection;
- Spazmonet and Spazmonet Forte tablets;
- Spazoverin tablets;
- Spakovin tablets and solution for injections.
- Nikoverin tablets;
- Papaverine tablets, rectal suppositories, injection;
- papaverine hydrochloride tablets;
- Papazol tablets;
- Platifillin with papaverine tablets;
- Platyfillin hydrotartrate tablets.
What are Drotaverin tablets from? The drug is one of the most effective and most commonly used medicines, which has an effect on the smooth muscle tissues of the walls of the hollow organs of the genitourinary, digestive and cardiovascular systems, reducing their motor activity and removing pain and spasms, both muscular and nervous etiology .
With all this, the drug does not have serious side effects on the cardiovascular system and strong cardiovascular therapeutic activity. Drotaverine is a vasodilator, myotropic, antispasmodic and hypotensive drug. It contributes to a moderate expansion of blood vessels and a decrease in the tone and motility of the smooth muscles of the genitourinary and biliary system, the organs of the gastrointestinal tract, thereby relieving pain.
Due to the absence of serious negative consequences in the work of the cardiovascular system, medical workers often prescribe this drug in the cases described above.
Having a dilating effect on blood vessels, Drotaverine helps to fill the tissues of the body with oxygen and increases the permeability of cell membranes. The drug helps to increase the absorption of calcium ions by cells. Taking Drotaverine does not adversely affect the autonomic nervous system.
This drug has established itself as an effective remedy for renal, intestinal and biliary colic, which are the result of spasms in the muscles of the digestive system. Cholecystitis, postcholecystomic syndrome, papillitis, pericholecystitis, colitis, cholangitis, cholecystolithiasis - this is not a complete list of diseases of the biliary system for which Drotaverine is prescribed.
Drotaverine is the main drug in the treatment of such diseases of the urinary tract as urethrolithiasis, nephrolithiasis, cystitis, bladder tenesmus, pyelitis, as it easily copes with spasms of the smooth muscles of the urogenital system.
The drug is effective in spasmolytic manifestations of any origin: with spasms of the cervix during childbirth, peripheral, cerebral, coronary arteries, etc.
Drotaverin is also used in gynecology. If there is a threat of miscarriage, premature birth, as well as symptoms of dysmenorrhea and other gynecological diseases, doctors, in combination with others, often prescribe this drug.
As an adjunct treatment, Drotaverine is prescribed for spasms of the smooth muscles of the gastrointestinal tract: gastritis, colitis with constipation, peptic ulcer of the stomach and duodenum, cardio- and / or pylorospasm, enteritis, irritable bowel syndrome, accompanied by. Also, as part of a complex treatment, Drotaverine is used for tensor headache to relieve vasospasm.
Method of application of the drug and dosage
The dosage of the drug depends on the characteristics of the patient's body, the severity of the disease and the age of the patient. For adults, the recommended dose should be 40-70 mg of Drotaverine several times a day. In this case, the maximum permitted daily dose, which is 240 mg, should not be exceeded.
Drotaverine is prescribed for children depending on age, it is allowed to take it only under the strictest medical supervision. So a child aged 3 to 6 years is allowed to take no more than 20 mg of the drug once. The daily dose cannot exceed 120 mg. For children aged 6 to 12 years, the recommended single dose is 40 mg, and the maximum daily dose is 200 mg.
Drotaverine begins to act approximately 45 minutes after ingestion. Excretion of this drug occurs 22 hours after ingestion, along with feces and urine. The form of release of the drug may be different, but Drotaverine is most often found in tablets. It should be taken orally, without chewing or crushing the tablet, with plenty of liquid. The drug is taken regardless of the meal.
Contraindications for use
As a rule, any drug has contraindications and side effects. Drotaverine is no exception, so it should be used carefully, be sure to read the instructions first. First of all, it should not be used by people who are hypersensitive to the components of this drug. It can cause nausea, respiratory arrest and other adverse effects.
Also contraindications to the use of this drug are:
- first trimester of pregnancy, lactation;
- severe renal, hepatic insufficiency;
- congenital lactose intolerance and lactose deficiency;
- angle-closure glaucoma, prostatic hyperplasia;
- stenosis of coronary vessels, etc.
The use of Drotaverine during pregnancy
Drotaverine during pregnancy is allowed to be used only as directed and in accordance with the dosage determined by the doctor. Under no pretext should you use it on your own initiative. Often this drug is used to relieve the tone of the uterus in case of a threatened miscarriage or premature birth, in the postpartum period to stop contractions, etc.
It is undesirable for pregnant women to take Drotaverine, unless the doctor has prescribed Drotaverine for you. Interestingly, Drotaverine, like Duphaston, Actovegin and Curantil, is not prescribed anywhere in the world, except for the countries of the former USSR, during pregnancy. In most European countries, Drotaverine is not registered and its effect on the unborn child has not been studied. And in those countries where it is registered, the instructions clearly state that pregnancy is a contraindication for use.
The world knows the results of a study by Hungarian scientists regarding the effect of Drotaverine on the unborn baby. They traced the effect of this drug on the fetus at different stages of its development and came to the conclusion that the drug does not cause any mutations and mutilations and its use does not entail the development of any abnormalities in the fetus.
In the modern world, Drotaverine is used in medical practice more and more often. In Western countries, men, having learned that Russian doctors have prescribed Drotaverin to their Russian wives, panic, because they have not even heard of such a drug. At the same time, Drotaverin in its composition is very similar to the widely used drug Duspatalin in the West, in the studies of which no negative effects on the fetus were also found. Considering all the above, it can be concluded that
Drotaverine is fairly safe during pregnancy. But to say that it is absolutely harmless is also not worth it.
Along with many other drugs, Drotaverine has its own contraindications, which pregnant women should not forget about. Therefore, the expectant mother should carefully weigh all the possible positive and negative consequences. If the doctor insists on taking this medicine, but the fears for the health of the unborn baby are very strong, you should ask the doctor to select an analogue contained in the international register of medicines.
And drotaverine - which drug is better? Consumer reviews in the video review:
Tell your friends! Share this article with your friends on your favorite social network using the social buttons. Thank you!
Telegram
Along with this article read:
Can No-shpu be taken during pregnancy? Indications for...
Loading...