Exoderil cream - for what? Exoderil instructions for use ointment for external use Average cost of Exoderil

Exoderil is a topical antimycotic agent belonging to the group medicines- allylamines.

Exoderil is a popular antifungal agent of synthetic origin. The main component in its composition is naftifine, which belongs to the group of allylamines and is used in most medications that have a similar effect.

The mechanism of action of the active component is to disrupt the formation of ergosterol, a substance that is part of the cell membrane of the fungus. Naftifine inhibits epoxidase synthesis. After which, the formation of ergosterol becomes impossible. Yeast fungi of the genus Candida, trichoviton - are completely destroyed.

Naftifine is effective against dermatophytes, yeast, mold fungi and other species. Exoderil is actively used in the treatment various types fungal infections caused by pathogenic microorganisms of yeast fungi (Pityrosporum, Candida), pathogenic dermatophytes of the genus Trichophyton, Microsporum, Epidermophyton, molds Aspergillus and other varieties of fungi.

Exoderil is fungicidal against some fungi, and fungistatic against others. The medicine has an anti-inflammatory effect, due to which the symptoms of inflammation, in particular itching, quickly disappear.

Exoderil is available in the form liquid solution(drops) and cream (ointment). Exoderil in solution form is more effective than cream for the treatment of fungal infections in the scalp or on smooth skin with areas of hyperkeratosis. In all other cases, it is recommended to choose any dosage form that you like best for some subjective reason.

The solution and cream have a one percent concentration of naftifine (10 mg/g). Exoderil can only be used externally; taking it internally is strictly prohibited. Thanks to various forms release of the drug, it is prescribed for fungal diseases of almost any localization: smooth skin, scalp and nails (onychomycosis).

Complex therapy is carried out by local application of ointment, solution or drops and by mouth other system antifungal drugs, which causes the pronounced healing effect and achieving long-term remission.

When used externally, it penetrates well into various layers of the skin in concentrations sufficient for antifungal action. When applied to a nail affected by fungus, the solution penetrates deeply into the nail canals due to its liquid consistency.

Indications for use Exoderil

Exoderil cream and solution are used as local therapy for fungal infestations caused by fungi susceptible to naftifine, namely:

cutaneous candidiasis;
interdigital mycoses;
fungal infections of skin folds and skin;
inflammatory dermatomycosis, as accompanied skin itching, and without it;
fungal infections of the fingernails and toenails (onychomycosis).

For a solution for external use additionally:

mycosis of the external auditory canal.

Local application of ointment or cream to affected areas of the skin prevents secondary infection by bacterial flora.

Instructions for use Exoderil, dosage

Locally in the form of an ointment or solution: apply 1 time/day to problem areas of the skin, which must first be cleaned and thoroughly dried, covering approximately 1 cm of healthy skin at the edges of the affected area.

The duration of therapy for dermatomycosis is 2–4 weeks. (if necessary - up to 8 weeks), for candidiasis - 4 weeks.

For infections of the nail plates, the drug should be used 2 times a day with a duration of therapy of up to 6 months. For onychomycosis, before the first use of the solution, it is necessary to remove as much of the affected part of the nail as possible with scissors and a nail file.

After using the drops, it is enough to wait just a couple of minutes, since their active component penetrates perfectly through the horny plates and is also well absorbed into the adjacent soft tissues.

The duration of treatment depends on individual characteristics (including the rate of nail growth in patients suffering from onychomycosis), and, as a rule, is about 6-7 months.

Features of application

The individual dosage may vary depending on the extent of the lesion, its type and location, and the doctor will be able to accurately calculate it.

As shown practical experience dermatologists, in case of severe fungal infection, it is worth adding tablets or other systemic antifungal drugs to the use of Exoderil.

The drug is used externally and does not affect the psychomotor reactions of the body. Data on the compatibility of therapy with simultaneous administration no alcohol available.

Side effects and contraindications Exoderil

The drug is usually well tolerated by patients; in isolated cases, local adverse reactions, including dryness and redness of the skin, as well as a burning sensation at the site of application of the drug.

Local irritant effect: dryness, skin hyperemia, burning, irritation.

Side effects during therapy usually disappear quickly and do not require discontinuation of the drug.

Overdose

Symptoms – increased side effects.

Therapy is symptomatic.

Contraindications

period breastfeeding(efficacy and safety have not been determined to date);
pregnancy period (efficacy and safety have not been determined).

In addition, Exoderil should not be applied (patient reviews confirm this) to the wound surface.

Prohibited use this remedy in the presence of individual intolerance to one of the components.

In childhood, the drug should also be prescribed with caution. The doctor may choose, for example, a reduced dose.

Analogues of Exoderil, list of drugs

Analogues of Exoderil are the following drugs (list):

Mycoderil;
Clotrimazole;
Fluconazole;
Futsis (Fusys);
Livarole;
Fetimin;
Naftifine.

It is important to understand that the instructions for use of Exoderil, price and reviews do not apply to analogues and cannot be used as a guide when using or replacing Exoderil with analogues. Any actions must be agreed with the attending physician; they may be required additional actions to change the treatment regimen.

Exoderil, regardless of the form of release, has a complex and systemic effect on the affected areas. It is aimed at relieving inflammation, fighting bacteria and, directly, fungus. At the same time, the anti-inflammatory activity of the drug is comparable to hormonal and antihistamines. medicines.

Active ingredient: naftifine hydrochloride

1 g of cream contains naftifine hydrochloride 10 mg

Excipients: sodium hydroxide, benzyl alcohol, sorbitan stearate, cetyl palmitate, cetyl alcohol, stearyl alcohol, polysorbate 60, isopropyl myristate, purified water.

Dosage form

Basic physicochemical characteristics: white, soft or slightly syrupy, shiny cream with a slight characteristic odor.

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Pharmacological group

Antifungal agents for use in dermatology.

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Pharmacological properties

Pharmacological.

Exoderil ® is an antifungal agent of the allylamine class. His active component is naftifine hydrochloride, the mechanism of action of which is associated with inhibition of the action of ergosterol.

Naftifine is active against dermatophytes such as trichophyton, epidermophyton and microsporum, yeast (Candida), mold (Aspergillus) and other fungi (for example, Sporothrix schenckii). In relation to dermatophytes and aspergillus, naftifine in vitro has a fungicidal effect against yeast fungi - it exhibits a fungicidal or fungistatic effect depending on the strain of the microorganism.

Exoderil ® also exhibits antibacterial activity against gram-positive and gram-negative microorganisms that can cause secondary bacterial infections along with mycotic lesions.

In addition, Exoderil ® has powerful anti-inflammatory properties.

Pharmacokinetics.

Naftifine hydrochloride is quickly absorbed and forms stable antifungal concentrations in different layers of the skin. Approximately 4% of the dose applied to the skin is absorbed, so the systemic effect of the active substance is very low. Only trace amounts of naftifine appear in blood plasma and urine. The active substance is almost completely metabolized; metabolites do not have antifungal activity and are excreted in feces and urine. The half-life is 2-4 days.

Indications

Local treatment fungal infections caused by naftifine-sensitive pathogens:

fungal infections skin and skin folds;
interdigital mycoses;
fungal nail infections (onychomycosis)
cutaneous candidiasis;
pityriasis versicolor;
inflammatory dermatomycosis, accompanied by or without itching.

Contraindications

Increased sensitivity to naftifine or other components of the drug. The drug should not be applied to the wound surface. Do not use for eye treatment.

Interaction with other drugs and other types of interactions

No interaction studies have been conducted.

Features of application

Use the drug for diseases of nails and skin only externally!

Use during pregnancy or breastfeeding.

There are no or limited data on the use of naftifine in pregnant women. Results from animal studies do not indicate the existence of direct or indirect harmful influence drug for reproductive function. The drug can be used during pregnancy and breastfeeding only if emergency after a careful assessment of the benefit/risk ratio, which is determined by the doctor.

Breastfeeding women should avoid contact of the drug with the skin and digestive tract child.

The ability to influence the reaction rate when driving vehicles or other mechanisms.

Does not affect.

Directions for use and doses

Exoderil ® cream should be applied to the affected skin surface and adjacent areas once a day after thoroughly cleaning and drying it, covering approximately 1 cm of healthy skin at the edges of the affected area.

The duration of treatment for dermatomycosis is 2-4 weeks (if necessary - up to 8 weeks); for candidiasis - 4 weeks; for nail infections - up to 6 months.

For fungal nail diseases, it is recommended to use the drug 2 times a day. Before the first use, it is necessary to remove as much of the affected part of the nail as possible with scissors or a nail file (to facilitate this procedure, on the recommendation of a doctor, the nails can be treated with a special rosemary agent).

To prevent relapses, treatment should be continued for at least 2 weeks after the main symptoms of the disease disappear.

There is insufficient data on the effectiveness and safety of the drug in children, therefore it is not recommended to prescribe Exoderil ® to patients of this age category.

Overdose

Acute overdose with topical application of naftifine was not observed.

Systemic intoxication with external use of the drug is unlikely due to the fact that a small amount of the active substance is absorbed through the skin.

Cream Exoderil contains naftifine hydrochloride at a concentration of 10 mg/g, as well as sodium hydroxide, alcohols (benzyl, cetyl and stearyl), sorbitan stearate, cetyl palmitate, polysorbate 60, isopropyl myristate, purified water.

Part solution actively active substance included in a concentration of 10 mg/ml. Excipients: propylene glycol, ethanol and purified water.

Release form

Exoderil solution(Exoderil) 1%. Dark glass bottles 10 and 20 ml, cardboard pack 1.
Cream (ointment) Exoderil(Exoderil) 1%. Aluminum tubes 15 and 30 g, cardboard pack 1.

pharmachologic effect

Antimycotic , fungistatic , fungicidal .

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Amorolfine is used for fungal infections of the nail caused by Epidermophyton, Trichophyton, Mycrosporum, Coccidoides, Cryptococcus, Wangiella, Pityrosporum, Candida, Hendersonula, Histoplasma, Sporothrix, Alternaria, Cladosporium, Fonseceae, Scopulariopsis.

Fungicidal and antibacterial activity Exoderil is due to the properties of the synthetic antimycotic it contains naftifina .

Since the drugs differ in composition, judge which is more effective - Exoderil or Lotseril - not entirely correct.

Lotseril used for treatment nail fungus , its analogue can be used both for treatment nail fungus , and for treatment ringworm . Moreover, the solution penetrates the nail plate better than varnish and acts the same regardless of whether the structure of the nail is damaged or not.

The disadvantages of nail polishes are their inability to penetrate into the channels of the nail plate, as well as into loose and crumbled nail plates.

Reviews allow us to conclude that Exoderil is quite effective against infections caused by the most common fungi today, however, it is powerless against some organisms that its analogue can easily cope with.

Thus, the choice in favor of one or another remedy must be made taking into account the diagnosis, pathogen and degree of damage.

Mikozan or Exoderil - which is better?

The drug is a kit for removing fungal infections from the nail. The product is available in the form of a serum and is supplied with disposable nail files and an applicator brush, which makes it easier to apply the medicine to the affected nail.

Active substance Mikozana - rye enzyme filtrate. When applied to the nail, the drug has a local antifungal effect , while increasing the density of the nail plate, reducing its porosity and creating conditions unfavorable for the growth of pathogenic fungi.

Experts often recommend using Mikozan for prevention, however, patients who have used this drug for treatment speak of it as an effective and really helpful remedy when it comes to onychomycosis .

If the affected area is not limited to the nail, then it is more advisable to use Exoderil to treat adjacent areas of the skin.

For children

Experience clinical application is absent in children, and therefore it is not recommended to prescribe drops/cream to this category of patients.

Use during pregnancy

Provided that the drug is used in accordance with the recommendations given in the instructions, its effect on the fetus/newborn is unlikely.

The results of teratogenicity studies indicate that there is no risk of any embryotoxic effects.

During pregnancy and breastfeeding, the medicine can be used only after a thorough assessment by the doctor of the expected effect of therapy/risk ratio.

Breastfeeding women should avoid getting the solution/cream on the skin and in the baby's digestive tract.

Reviews about Exoderil

Reviews about Exoderil cream, as well as reviews about Exoderil solution, can be found on forums that are different: for some, this drug helps restore the health of their nails and skin, for others, on the contrary, even after 2-3 months of using the product, there is no improvement notices.

Experts say that you can get rid of nail/skin fungus only if the treatment is carried out correctly.

Since with fungal infections of the feet, pathological process in about half of the cases it also spreads to the nails; it is considered advisable to combine ointment and drops: for example, a solution with nail fungus Apply in the morning, and at night the skin and affected nail plates are treated with cream.

Any external means (drops, cream or varnish) from nail fungus should be used regularly and over a long period of time.

At the same time, it is very important (especially during the treatment period) to properly care for your nails/skin (for example, once a week, give your nails a bath with soda and laundry soap), do not forget about personal hygiene and the need to disinfect all surfaces in contact with the fungus.

At severe forms fungal infection topical antimycotics (Exoderil or its analogues) to achieve positive effect combined with systemic drugs.

How much does Exoderil cost?

Cost of the drug in Ukraine

The price of Exoderil in Kyiv is from 117 UAH. Ointment in tubes of 15 g can be bought for an average of 130 UAH. The price of Exoderil 10 ml in Ukraine is from 150 UAH, the medicine in 20 ml bottles in Dnepropetrovsk, Kharkov, Odessa or Zaporozhye costs 305-310 UAH.

Cost of the drug in Russia

You can buy Exoderil in Moscow at a price of 425 rubles: the price of Exoderil cream 15 g is 425-530 rubles, 30 g is 770-830 rubles; the price of Exoderil solution 10 ml is 510-710 rubles, drops in 20 ml bottles cost 860-1020 rubles.

Systemic agents (tablets, solution, etc.) are not produced under the Exoderil brand. You can treat nail fungus using both dosage forms the drug according to the scheme: cream in the evening, solution in the morning.

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ZdravCity

Exoderil cream 1% 30g Sandoz GmbH

Exoderil solution external 1% 30ml n1

Exoderil solution external 20ml n1Globopharm Pharmaceutical Products/Sandoz GmbH

Exoderil cream 1% 15g Sandoz GmbH

Exoderil solution external 1% 10mlGlobopharm Pharmaceutical Products/Sandoz GmbH

Pharmacy Dialogue

Exoderil solution (vial 1% 20ml)

Exoderil solution 1% 10ml

Exoderil cream (tube 1% 30g)

Exoderil cream tube 1% 15g

Antifungal drug for external use from the allylamine group. The mechanism of action is associated with inhibition of the synthesis of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus.

The drug is active against dermatophytes Trichophyton, Epidermophyton, Microsporum, yeast (Candida spp., Pityrosporum), molds (Aspergillus spp.) and other fungi (Sporotrix schenckii). Naftifine has a fungicidal effect against dermatophytes and aspergillus. It exhibits fungicidal or fungistatic activity against yeast fungi, depending on the strain of the microorganism. The drug has antibacterial effect against gram-positive and gram-negative microorganisms that can cause secondary bacterial infections.

The drug has an anti-inflammatory effect, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.

Pharmacokinetics

Naftifine quickly penetrates the skin, creating stable antifungal concentrations in its different layers, possibly local application 1 time/day

Release form

Solution for external use 1% transparent, colorless or slightly yellow color, with the smell of ethanol.

Excipients: propylene glycol - 50 mg, ethanol - 400 mg, purified water - 475 mg.

10 ml - dark glass bottles with a dropper stopper (1) - cardboard packs.
20 ml - dark glass bottles with a dropper stopper (1) - cardboard packs.

Dosage

Exoderil ® should be applied to the affected skin surface and adjacent areas 1 time per day, after thorough cleaning and drying, covering approximately 1 cm of healthy skin at the edges of the affected area.

The duration of treatment for dermatomycosis is 2-4 weeks (if necessary - up to 8 weeks), for candidiasis - 4 weeks.

For onychomycosis, before the first use of the solution, it is necessary to remove as much of the affected part of the nail as possible with scissors and a nail file. The drug should be used 2 times a day, the duration of treatment is up to 6 months.

To prevent recurrence of infection, therapy should be carried out for at least 2 weeks after the disappearance of clinical symptoms.

Overdose

No cases of overdose have been reported.

Interaction

Not checked drug interactions the drug Exoderil ® with other drugs.

Side effects

Local reactions: in some cases - dry skin, hyperemia, burning.

Side effects are reversible and do not require discontinuation of therapy.

Indications

fungal infections of the skin and skin folds (tinea corporis, tinea inguinalis), incl. interdigital mycoses (tinea manum, tinea pedum);
fungal nail infections (onychomycosis);
skin candidiasis;
pityriasis versicolor;
ringworm (with or without accompanying itching).

Exoderil ® is effective in the treatment of mycoses affecting the skin area with hyperkeratosis, as well as in the hair growth area.

Contraindications

pregnancy (safety and effectiveness have not been determined);
lactation period (safety and effectiveness have not been determined);
hypersensitivity to naftifine or propylene glycol.

Application of the drug to the wound surface is contraindicated.

Features of application

Use during pregnancy and breastfeeding

The use of the drug Exoderil ® is contraindicated during pregnancy and lactation (safety and effectiveness have not been determined).

Use in children

Carefully: childhood(experience with clinical use is limited).

special instructions

The drug is not intended for use in ophthalmology. Avoid contact of the drug with the eyes.

No special measures are required to destroy the drug.

Impact on the ability to drive vehicles and operate machinery

The drug does not have negative influence on the ability to drive vehicles and perform other activities that require concentration and speed of psychomotor reactions.

Antifungal drug for external use

Active substance

Release form, composition and packaging

◊ Cream for external use white, homogeneous or slightly granular, shiny, with a weak characteristic odor.

Excipients: sodium hydroxide - 1.2 mg, benzyl alcohol - 10 mg, sorbitan stearate - 19 mg, cetyl palmitate - 20 mg, cetyl alcohol - 40 mg, stearyl alcohol - 40 mg, polysorbate 60 - 61 mg, isopropyl myristate - 80 mg, water purified - 718.8 mg.

15 g - aluminum tubes (1) - cardboard packs.
30 g - aluminum tubes (1) - cardboard packs.

pharmachologic effect

A drug active regarding dermatophytes Trichophyton, Epidermophyton, Microsporum, yeast (Candida spp., Pityrosporum), molds (Aspergillus spp.) and other fungi (Sporotrix schenckii). Naftifine has a fungicidal effect against dermatophytes and aspergillus. It exhibits fungicidal or fungistatic activity against yeast fungi, depending on the strain of the microorganism. The drug has an antibacterial effect against gram-positive and gram-negative microorganisms that can cause secondary bacterial infections.

The drug has an anti-inflammatory effect, which contributes to the rapid disappearance of symptoms of inflammation, especially itching.

Pharmacokinetics

Suction and distribution

When applied externally, naftifine penetrates well into various layers of the skin, reaching concentrations sufficient to provide an antifungal effect.

After application of the cream to the skin, less than 6% of the active substance is subject to systemic absorption.

Metabolism and excretion

The absorbed amount is partially metabolized and excreted by the kidneys and intestines. T 1/2 is 2-3 days.

Indications

Contraindications

pregnancy (safety and effectiveness have not been determined);
lactation period (safety and effectiveness have not been determined);
hypersensitivity to naftifine, benzyl alcohol or other components of the drug.

WITH caution: children's age (experience of clinical use is limited).

Dosage

It should be applied to the affected skin surface and adjacent areas 1 time/day, after thorough cleaning and drying, covering approximately 1 cm of healthy skin at the edges of the affected area.

Duration of treatment at dermatomycosis- 2-4 weeks (if necessary - up to 8 weeks), with candidiasis - 4 weeks.

At onychomycosis Before using the cream for the first time, you must remove as much of the affected part of the nail as possible using scissors and a nail file. The drug should be used 2 times a day, the duration of treatment is up to 6 months.

For preventing recurrence of infection Therapy should be carried out for at least 2 weeks after the disappearance of clinical symptoms.

Side effects

Local reactions: in some cases - dry skin, hyperemia, burning.

Side effects are reversible and do not require discontinuation of therapy.

Overdose

No cases of overdose have been reported.

Drug interactions

There were no drug interactions between the drug Exoderil and other drugs.

special instructions

The drug is not intended for use in ophthalmology. Avoid contact of the drug with the eyes.