Almost everyone who has heart problems or suffers from high blood pressure, familiar with the drug, because it is usually the first thing that doctors prescribe.
This high-quality drug, the active ingredient in which is bisoprolol, has proven itself well, therefore it is often used in complex treatment in conjunction with other drugs.
In the instructions for the drug Concor, compatibility with other drugs is described especially carefully, since there is a whole list of drugs with which it is absolutely impossible to use it. We will talk about them in detail in our article.
A medication belonging to the group of beta-blockers is successfully used to treat a wide range of diseases. of cardio-vascular system. His main active substance- bisoprolol - blocks the action of adrenaline and other catecholamines on the heart muscle, as well as stimulating nerve impulses of the central nervous system.
Tablets Concor
The drug has a sparing effect, but the effect is not observed instantly, but only after an appropriate course of treatment.
As a result of the reception, the frequency and strength of heart contractions decrease, due to which the need for the heart muscle to receive oxygen decreases, in addition, the heart rhythm normalizes.
Unlike some analog drugs, bisoprolol acts selectively, only on the heart muscle, with virtually no effect on other internal organs - bronchi, pancreas, due to which the likelihood of manifestation side effects noticeably decreases.
The drug is prescribed in the presence of the following pathologies:
- high blood pressure;
- coronary artery disease;
- angina;
- stage of compensation for chronic heart failure.
People who regularly use this drug course, the likelihood of a heart attack and other consequences of hypertension decreases.
Compatibility with drugs with a similar effect
You have to be careful with different antihypertensive drugs central action such as Reserpine, Guanfacine, Moxonidine and Methyldop.
Their combination can lead to a sharp violation heart rate and further pressure drop.
Pay attention to other drugs that directly or indirectly lower blood pressure, such as antispasmodics, diuretics, barbiturates, they can also enhance the effect of the drug and lead to an attack of hypotension.
However, in some cases, the attending physician may prescribe drugs with antihypertensive action together with Concor, if he considers that he alone will be ineffective, as a rule, this is one of the following means:
- Amlodipine which is used at high pressure. However, the answer to the question of whether Concor and Amlodipine can be taken will be negative if there is heart failure;
- with a diuretic and vasodilating effect, used for hypertension, with a minimum of side effects. Concor and Indapamide have good compatibility;
- Noliprel- another drug that can reduce pressure, related to potent;
- Cardiomanil- an aspirin-based drug, previously often used to treat hypertension. Can Concor and Cardiomagnyl be taken together? Based on recent studies, its effectiveness and safety are questionable, as a rule, it is not prescribed now.
Amlodipine tablets
No less dangerous is the intake of cardiac glycosides, which are usually used by people with heart failure, with their simultaneous use, conduction is disturbed, which can provoke atrioventricular blockade.
It is dangerous to prescribe Concor in combination with various adrenomimetics that stimulate alpha and beta receptors; in this case, peripheral pressure may increase.If you are already taking them, you should stop taking them and wait at least 2 weeks before you start using Concor.
You should tell your doctor all the drugs you are using, as even those used topically can increase the effect of taking them together, for example eye drops from glaucoma based on beta-blockers.
Drugs that reduce effectiveness
When taking medicines, it should be borne in mind that drugs of the oppositely directed group weaken its effect. First of all, these include beta-agonists dobutamine or isoprenaline.
Below is a list of drugs that negatively affect the effectiveness of taking Concor, among them:
- female sex hormones estrogens;
- glucocorticosteroids (Hydrocortisone, Prednisolone, Dexamethasone, etc.);
- anti-inflammatory nonsteroidal drugs (Acetylsalicylic acid, Analgin, Paracetamol, etc.).
It is not necessary to stop taking them in the treatment of hypertension, however, it should be taken into account that its effect will be lower and focus the attention of the doctor on this, in some cases it may increase the dosage.
Remedies to be taken with caution
Exist special instructions for people suffering from diabetes.
If they use insulin and hypoglycemic drugs in tablets, it must be taken into account that bispoprolol, the main active ingredient of Concor, potentiates their action.
An additional danger of co-administration is that Concor reduces the manifestations of tachycardia, which in diabetics is a signal of a decrease in blood sugar levels, due to which the patient may miss dangerous symptom hypoglycemic coma may develop.
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Instructions for use of the drug:
As you can see, the list of drugs that are not recommended to be taken with Concor is very extensive. Some combinations simply reduce the effectiveness of the drug, and some can lead to very backfire. That is why this drug should be prescribed only by a doctor, having previously discussed with the patient all the drugs used by him in this moment medicines. Inform the doctor not only about certified drugs from the pharmacy network, but also about dietary supplements and medicinal herbs if you accept them.
People suffering from hypertension are highly dependent on taking pills. "Lozap" and "Concor" - medical preparations which are often prescribed by physicians for effective treatment heart and maintaining normal functionality. In this case, the patient faces the question: why do we need drugs, which one is better to choose? And when hypertension it is recommended to use two drugs in combination.
How do drugs work?
The mechanism of work "Lozap"
(the second name is "Lozap plus") refers to pharmacological group angiotensin II antagonists and is used to treat hypertension. The drug losartan reduces peripheral vasospasm, which leads to a decrease in blood pressure and reduces the load on the heart. Possessing a diuretic effect, losartan is able to reduce the amount of adrenaline and aldosterone in the blood, removing substances from the liquid. Maximum healing effect occurs in 3-6 weeks with constant use.
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The mechanism of work "Concor"
"Concor" effectively affects high pressure. "Concor" is a common remedy, effective medicine from high blood pressure chronic insufficiency heart, ischemia, angina pectoris. The curing substance bisoprolol is a medicinal protection of the heart from the influence of adrenaline and similar elements of the catecholamine group. This means that you need to take Concor to lower blood pressure and stabilize your pulse, reduce the risk of heart attack and other complications with hypertension. Due to the composition, the drug has almost no effect on the bronchi, pancreas and, most importantly, the heart muscle. Tablets act after 2-3 weeks.
What's better?
"Concor" and "Lozap" have a different effect: "Concor" treats the heart directly, "Lozap" - affects blood vessels and pressure. It is more effective to take the tablets at the same time.
"Lozap" promotes vasodilation. The scheme of the drugs is different: "Lozap" dilates blood vessels and reduces peripheral pressure, "Concor" - reduces cardiac output. The composition of the drugs includes various healing substances: bisoprolol protects the heart from the effects of adrenaline and similar substances, while losartan removes an extra percentage of these hormones from the body. Therefore, despite the main work - lowering blood pressure, it is illogical to compare two drugs, and even better - to entrust the matter to a specialist.
Can it be taken together?
In the case when blood pressure is much higher than normal and treatment with one medication does not work, it is recommended to take Lozap and Concor together. Drug compatibility shows that pills enhance therapeutic effect each other through different mechanisms of action. Both reduce pressure, make the heart work in a “calm” mode. When the body tolerates the combination of 2 drugs, it is allowed to take them for a long period at the same time. It is important to keep the pulse and blood pressure under control, to pass annual surveys at the doctor's.
Indications and contraindications
Have pills total indication- hypertension, but contraindications are different. Let's take a closer look at the table.
reduce blood pressure and to improve the functioning of the cardiovascular system as a whole, beta-1-blockers are excellent help. A good drug in this segment is Concor.
The drug helps to stabilize blood pressure, and also has antiarrhythmic and antianginal effects (eliminates symptoms coronary disease hearts).
The drug is available in the form of tablets for oral administration. There are tablets with 2.5 mg, 5 mg and 10 mg of the active ingredient. The price of the medicine in a pharmacy is about 150-400 rubles for a package of 30 tablets (the cost depends on the amount of active ingredient in the tablet).
How does the drug work?
Arterial hypertension is the most common pathology of the cardiovascular system. Unfortunately, it is impossible to cure the disease, but it is quite possible to achieve stabilization of the patient's condition.
For this, medications with a pronounced antihypertensive effect are used. Beta-1-blockers are widely used. One of the most effective drugs in this segment is Concor.
Doctors are often asked the question, does Concor lower blood pressure or not? Of course, it reduces, because the drug has a pronounced hypotensive effect. Even patients have a question, does Concor lower blood pressure or only pulse? The drug has a pronounced antiarrhythmic, antianginal and hypotensive effect, therefore, when using tablets, both blood pressure and pulse are stabilized.
Consider the principle of action of the drug. So, it includes:
- The active ingredients are bisoprolol hemifumarate and bisoprolol fumarate (2:1 ratio).
- Excipients - crospovidone, magnesium stearate, microcrystalline cellulose, silicon dioxide, calcium hydrogen phosphate, corn starch.
- The composition of the shell is hypromellose, yellow iron oxide, dimethicone, macrogol 400, titanium dioxide.
The active ingredients reduce the activity of the sympathoadrenal system by blocking the beta-1-adrenergic receptors of the heart. The substance has an antihypertensive effect by reducing cardiac output and inhibition of rinin secretion. In addition, the active ingredients affect the baroreceptors of the carotid sinus and aorta.
The advantage of the drug is the fact that its active ingredients have a low affinity for beta-2 receptors of the smooth muscle structure of the bronchi, blood vessels and endocrine system. Due to this, when using the drug, it is possible to avoid affecting the metabolism of glucose, bronchi and peripheral arteries. Long-term use Concora helps to reduce increased peripheral vascular resistance.
In patients with ischemic heart disease and chronic heart failure, the active ingredients help to reduce the number of heart contractions. Also, substances reduce the stroke volume of the heart, myocardial oxygen demand and ejection fraction.
Absorption of active components from the intestine - 90%. The bioavailability index is 90%. Food does not affect absorption. The highest concentration of the active component in the blood plasma is observed after 3 hours. Plasma protein binding is about 30%. Derivatives are excreted by the kidneys. The half-life is about 12 hours.
In patients over the age of 75, no changes in the pharmacokinetics of the drug were observed, so the tablets can be freely taken by elderly hypertensive patients.
Instructions for use of the drug
It has already been noted above that Concor lowers blood pressure, so a beta-blocker should be taken by patients suffering from arterial hypertension. Moreover, the medicine can be combined with other antihypertensive pills. Among the indications for use, coronary heart disease and chronic heart failure can be noted.
How to take Concor with high blood pressure? It should be noted right away that adults and elderly patients need to take a single dose, preferably in morning time. Tablets should not be chewed - they must be swallowed whole with a small amount of water.
The starting dosage is 5 mg (half of a 10 mg tablet, a whole tablet of 5 mg, 2 tablets of 2.5 mg). If this dose is ineffective, then it can be increased by 2 times. Maximum daily dosage is 20 mg. In the treatment of chronic heart failure, 5-10 mg should be taken.
How long can you take the tablets? In the instructions for use, the duration of therapy is not regulated. The scheme and duration of treatment are selected on a strictly individual basis by the attending physician.
With caution, Concor should be taken by persons in whom arterial hypertension is accompanied by diabetes mellitus.
Contraindications and side effects
Drinking Concor tablets is not possible in all cases. The beta-blocker has a number of contraindications for use. Let's consider them in more detail:
- Acute heart failure.
- Decompensated form of chronic heart failure.
- Hypotension (low blood pressure).
- Minor age.
- Hypersensitivity to the components of the drug.
- Bronchial asthma, chronic obstructive pulmonary disease.
- Bradycardia.
- Sinoatrial blockade.
- metabolic acidosis.
- Severe changes in arterial peripheral circulation.
- Pheochromocytoma.
For pregnant and lactating women, Concor is prescribed only if the positive effects of taking the pills outweigh the risk to the child. The side effects of the tablets are discussed in the summary table provided below.
| Organ or system. | Description. |
|---|---|
| Nervous system. | Headache, dizziness, sleep disturbances, depression, hallucinations, paresthesia, asthenia symptoms. |
| organs of vision. | Decreased lacrimation, conjunctivitis. |
| Hearing organs. | Reversible hearing loss. |
| The cardiovascular system. | Patients with chronic heart failure often experience bradycardia (low heart rate). You can also note the feeling of numbness of the limbs, orthostatic hypotension, violation of atrioventricular conduction. |
| Respiratory system. | Bronchospasm, rhinitis, obstructive airways disease. |
| Organs of the gastrointestinal tract. | Constipation, diarrhea, vomiting, nausea. |
| Liver. | An increase in the level of triglycerides in the blood, an increase in the activity of liver enzymes (AST, ALT) in the blood plasma, hepatitis. |
| Skin and musculoskeletal system. | muscle weakness, convulsions, hypersensitivity reactions, rash, excessive sweating, hair loss. Patients with psoriasis may experience a psoriatic rash. |
| Urogenital system. | Decreased potency. |
In case of overdose, heart failure, severe bradycardia, hypoglycemia, bronchospasm are observed. It is worth noting that Concor has a withdrawal syndrome. After abrupt cessation therapy, blood pressure may increase, a rapid pulse may be observed, and even a hypertensive crisis may develop.
Losartan potassium, the active ingredient of the drug Lozap (manufactured in Slovakia) belongs to drugs intended for the treatment of arterial hypertension, namely, to the group of angiotensin receptor blockers.To avoid this, the drug should be canceled smoothly, that is, gradually reduce the daily dose.
The fact is that with hypertension and some other types of arterial hypertension in the blood, the level of substances that can cause spasm increases. peripheral vessels and thus increase blood pressure.
These substances, in particular angiotensin, can exert their effect only by attaching to specific receptors. Lozap, as well as related drugs, blocks angiotensin receptors and turns off its effect on the body.
When taken together, the drugs Concor and Lozap mutually reinforce each other's action, since they have different mechanisms ...
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Question: arrhythmia?
I meant the antihypertensive drugs Lorista Concor Betaloc ZOK and their side effects in the form of arrhythmia. And I ask about Ribaksin as a treatment for arrhythmia. How effective is it.
Side effects when using the drug Concor: bradycardia (slow heart rate), impaired AV conduction (may cause some types of arrhythmias).
Possible adverse reactions when taking betalok: sinus bradycardia, cardiac arrhythmias, myocardial conduction disturbances.
From the foregoing, it follows that these drugs can cause arrhythmias and bradycardia.
The drug Riboxin has a weak effect in the treatment of arrhythmias.
I went to three cardiologists and everyone said in one voice do not stop taking beta-blockers, otherwise ...
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anonymously
Hello, dear Anton Vladimirovich! After a heart attack, in 2006 I underwent an angioplasty with stenting. After the operation, no disability group was established for me, and the cardiologist of the department prescribed the following medications for me for life: atorvostatin 10 mg, cardiomagnyl 75 mg. Lozap 50 mg and Concor 5 mg. All this once a day. And I have been drinking all this since February 2007. But now interesting things began to happen: I began to develop hypotension. After consultation with their local cardiologist, the dosage of Lozap was reduced to 25 mg. , and Concora - up to 2.5 mg. And still, the pressure is kept in low limits: 90-100 / 55-60, with a heart rate of 60-70 beats / min. At the same time, the ejection fraction is 68%, according to the pulse oximeter: 70, 95-97. What do you recommend? Can be still to reduce a dosage, or absolutely to cancel any preparation? I mean concor or lozap? I'd love to hear your opinion because...
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Concor is a popular medicine for high blood pressure, coronary heart disease, angina pectoris, and chronic heart failure. This is an original high quality drug, the active ingredient of which is bisoprolol. Below you will find instructions for use, written in an accessible language. Read the indications for use, contraindications, side effects. Find out how to take Concor - before or after meals, in the morning or in the evening, what should be the pulse and pressure, how to safely stop taking. The article provides detailed answers to 19 questions that are often asked by patients. Understand the difference between Concor tablets and Concor Cor. The article also provides a list of cheap analogues of these drugs.
Drug card
Instructions for use
Read detailed articles about the treatment of diseases:
See also video about treatment of coronary artery disease and angina
Together with this medicine they are also looking for:
Read the article "Pressure Pills: Questions and Answers".
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Archive: Serious Hypertension Questions
Elena 03/28/2013 22:26
Dear Sergey Valerievich!
I am 62 years old. In addition to hypertension, IHD.ASKS is diagnosed. I have been struggling with my pressure for a month and a half (after the crisis). For a long time (2 years) she took prestans 10/5, concor 2.5. And after the crisis, I tried several drugs. Now I take Equator 10/20 in the morning, physiotens 0.400 in the evening, cardiomagnyl 75. In the morning, the pressure is 130-140/80, the pulse is 70, and already at 19-20 hours. 150-170/95, and I take physiotherapy. Well, I also had a slight cough at night. Can you recommend me any drug more effective, and should I drink concor? Thank you for your work, good health to you!!
Answer:
Maximum daily dose Physiotension - 0.4 in the evening and 0.2 in the afternoon, respectively, you can add.
Equator contains lisinopril and amlodipine, lisinopril often gives a dry cough, so it must be replaced with any drug from the sartans group at half the maximum dosage (analogs-drugs.rf site - classes ...
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International name:
Bisoprolol (Bisoprolol)
Group:
Selective beta1-blocker (72)
Active ingredients:
bisoprolol
Dosage form:
coated tablets
Pharmachologic effect:
Selective beta1-blocker without its own SMA; It has antihypertensive, antiarrhythmic and antianginal effects. By blocking beta1-adrenergic receptors of the heart in low doses, it reduces the formation of cAMP from ATP stimulated by catecholamines, reduces intracellular Ca2+ current, has a negative chrono-, dromo-, batmo- and inotropic effect (slows heart rate, inhibits conductivity and excitability, reduces myocardial contractility). With increasing doses, it has a beta2-blocking effect. OPSS at the beginning of the use of beta-blockers, in the first 24 hours, increases (as a result of a reciprocal increase in the activity of alpha-adrenergic receptors and the elimination of stimulation of beta2-adrenergic receptors), which ...
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Concor Cor tablets are medicine prescribed for arterial hypertension for rapid decline pressure.
According to cardiologists, this is one of the most effective drugs that they take themselves and prescribe to their relatives with high blood pressure.
By far the most common disease is hypertension or hypertension. In other words, it is high blood pressure. This ailment develops due to external factors e.g. stress, fatigue, physical exercise, insufficient rest, sudden change in weather or illness internal organs. Unfortunately, this pathology cannot be completely cured - it is a chronic disease.
At the first sign of hypertension, you should immediately consult a doctor. The specialist will select an individual complex treatment, which will help keep blood pressure normal and eliminate severe symptoms. Any therapy includes diuretics. These drugs have different chemical composition However, they all effectively remove excess fluid from the body. Medicines are diuretics. Often, the doctor includes the drug Indapamide in the main therapy, instructions for the use of which and at what pressure the medicine should be taken, we will talk in this article.
General characteristics of the medicinal product
Indapamide is a well-known diuretic that is actively used in the treatment of hypertension, as well as swelling caused by heart failure. Tablets effectively remove excess fluid from the body and qualitatively dilate blood vessels, which helps to normalize blood pressure.
The drug is produced in the form of tablets, which are coated on top white color. In one package there can be 10 or 30 tablets, which allows a person to choose the required amount for himself.
The drug is produced by many pharmacological companies, but their composition does not change. The main active ingredient is indapamide. One tablet contains about 2.5 mg. In addition to this substance, the preparation contains additional components, which provide positive influence on the body. The drug contains the following auxiliary ingredients:
- potato starch;
- collidon CL;
- milk sugar or lactose;
- magnesium stearate;
- povidone 30;
- talc;
- cellulose.
Important! What kind of pressure helps Indapamide? The drug is prescribed for increased rate HELL. Its active components are able to quickly remove excess fluid from the body, and also qualitatively dilate blood vessels. Due to this effect, the drug effectively normalizes blood pressure.
The mechanism of action on the body
The drug has an active effect on the body. Its components quickly remove fluid and accumulated salts in the body. They encourage the rapid formation of urine, which helps to remove fluid from the tissues and serous cavities.
pharmachologic effect
Indapamide is a quality diuretic that belongs to thiazide-like diuretics. Additionally, the drug dilates the vessels and tones their walls. Together, these interactions can normalize blood pressure and improve general state person.
If the daily dose is 1.5-2.5 mg, then this is enough to prevent vasoconstriction. This means that the pressure will be within normal limits. In addition, this dosage helps to improve the walls blood vessels and protects the heart muscle from changes in blood pressure. In the event that the dosage of the drug is increased to 5 mg per day, then this amount will be enough to relieve swelling. However, an increased dose does not affect the level of pressure in any way.
With regular use, a noticeable effect is achieved after 7-14 days of taking the drug. The drug has the maximum effect after 2-3 months of therapy. Positive effect kept for 8 weeks. If the tablet is taken once, then the desired result occurs in 12-24 hours.
It is better to take the drug on an empty stomach or after a meal, since taking the pill with food slows down its effect on the body, but does not affect its effectiveness. The active components of Indapamide are rapidly absorbed into gastrointestinal tract so they are evenly distributed throughout the body.
The liver effectively cleanses the body of the chemical components of the tablets. They are also processed by the kidneys and excreted in the urine (70-80%) after about 16 hours. Excretion through the digestive system is about 20-30%. Basic active ingredient in its pure form, approximately 5% is excreted. All other parts of it have the necessary effect on the body.
Indications for use
Indapamide is effective drug, which is widely used in medicine to restore blood pressure. As a rule, doctors recommend it for such diseases of the body:
- hypertension 1 and 2 degrees;
- edema caused by heart failure.
How to use
Indapamide is recommended to take a tablet (2.5 mg) once a day. It must be swallowed whole, without chewing, and washed down with plenty of water. However, if therapy does not give the desired results after 1-2 months, then the established dosage must not be increased, as the risk of side effects increases. In this situation, the doctor may recommend changing the drug or supplementing it with another medicine.
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