Cetrin ( Cetrine) - modern antihistamine medicine, which has antiallergic, antiexudative, antipruritic effects. The medicine is produced in India pharmaceutical company Dr Reddy's Laboratories Ltd.
In the pharmacy chain, Cetrin is presented in the form of tablets containing 10 mg of Cetirizine, 20 tablets in blister packs and in the form of syrup containing 1 mg of Cetirizine in 1 ml.
How does Cetrin work for allergies?
The active ingredient of Cetrin is cetirizine (a metabolite of hydroxyzine), which is an H1-blocker. histamine receptors, a competitive histamine antagonist. Ceterizine effectively relieves allergy symptoms and also prevents its development. Having an antiexudative and antipruritic effect, Ceterizine helps limit the release of inflammatory mediators and prevents the release mast cells histamine, serotonin, bradykinin, reduces capillary permeability, prevents the migration of neutrophils, basophils, eosinophils, relieves smooth muscle spasm. When treating bronchial mild asthma degree of severity, Cetrin reduces histamine-induced bronchospasm.
No symptoms observed when taking therapeutic doses of Cetrin sedative effect. Therapeutic effect after taking 10 mg of the drug, it is observed after 30-60 minutes and lasts 1 day. At therapeutic dosages, addiction to the antihistamine effect does not develop. After stopping taking Cetrin, the effect lasts for 3 days.
Cetrin contains active components:
- Pills: active substance is cetirizine dihydrochloride (10 milligrams); excipients: starch, povidone, lactose, magnesium stearate, macrogol 6000, hypromellose, talc, titanium dioxide, polysorbate.
- Syrup: 1 ml contains 1 mg of cetirizine dihydrochloride; excipients: sucrose, glycerol, disodium edetate, benzoic acid, sodium citrate, sorbitol solution 70%, purified water, flavoring.
Ceterizine is absorbed fairly quickly after oral administration. maximum concentration in plasma is observed after 60 minutes. It is recommended to take the drug before meals, as digestive processes slow down its absorption.
A small amount of Cetirizine is metabolized in the liver. The medicine does not have a cumulative effect (does not accumulate in organs and tissues), penetrates into breast milk, and is excreted from the body primarily by the kidneys.
In case of violation excretory function kidneys, the half-life of the drug increases.
For what diseases is Cetrin prescribed?
Indications for the use of Cetrin are allergic diseases:
- Seasonal and year-round rhinitis, conjunctivitis;
- Drug and food allergies;
- Dermatoses of allergic origin (in complex treatment);
- Chronic recurrent urticaria;
- Quincke's edema;
- Atopic dermatitis (in complex treatment).
Contraindications and side effects
When treated with Cetrin, side effects may occur: headaches, dizziness, drowsiness, insomnia, hand tremors, depressive states. Also possible: dry mouth, nausea, vomiting, increased heart rate, increased blood pressure, allergic reactions.
Contraindications to the use of Cetrin are:
- Intolerance to the components of the drug;
- Pregnancy and lactation;
- For children under 6 years of age, Cetrin is prescribed in the form of syrup.
Methods of using Cetrin
Cetrin tablets are taken orally before meals with a small amount of water.
Adults and children over 12 years of age are prescribed 1 tablet. (10 milligrams) once daily.
For children over 6 years of age, give half a tablet (5 milligrams) twice a day.
Cetrin syrup is prescribed for adults and children over six years of age from 1 to 2 teaspoons (5-10 milligrams) once a day. For children from two to five years old, give ½ teaspoon. spoon once a day.
With hepatic and renal failure adults are prescribed half a tablet (5 milligrams) once a day.
The course duration of treatment is 1-4 weeks. In the treatment of chronic allergic diseases the duration of therapy can be increased to 6 months.Before taking Cetrin, read the instructions for use.
Can Cetrin be prescribed during pregnancy and breastfeeding?
The active substance Cetirizine penetrates the placental barrier and is found in breast milk, having a negative effect on the condition of the fetus and newborn, therefore the drug is contraindicated during pregnancy and breastfeeding.
Interaction with other drugs
Cetrin should be used with caution concomitantly with sedatives. When administered simultaneously with theophylline, accumulation of Cetirizine and overdose may occur.
An overdose of the drug is possible if the recommended dose is accidentally exceeded; it is accompanied by drowsiness, increased heart rate, hand tremors, itchy skin, and urinary retention. It is recommended to discontinue the drug, gastric lavage, and also take enterosorbents: Polysorb, Enterosgel, Enterosorb, Lactofiltrum, Activated carbon. There is no specific antidote.
Are there analogues of Cetrin?
Similar pharmacological properties have antihistamines: Zyrtec, Zodak, which include Cetirizine, as well as Loratadine, Clarotadine, Claritin, the main active ingredient of which is Loratadine, Erius (Desloratadine), Ketotifen. Medicines of the first group belong to the latest generation of antiallergic drugs; their price in pharmacies is slightly higher. The lowest cost among Cetrin analogues is for the drug Loratadine Verte. The effectiveness of antihistamines latest generation slightly higher.
How to properly store the medicine?
Cetrin is stored in a place protected from light. Storage temperature is from 15 to 25 degrees Celsius. The shelf life of the medicine is two years.
Price of medicine in a pharmacy chain
Cetrin can be purchased at most pharmacies. average cost the drug is:
- Cetrin syrup, 60 ml (1 mg/ml) - 95 - 105 rubles;
- Cetrin tablets (10 mg), No. 20 - 160 - 170 rubles.
Against the background of increased histamine production, lacrimation is observed, natural breathing is disrupted, and a sensation of itching and burning occurs. Development side effects extremely undesirable during pregnancy.
The therapeutic regimen for pregnant women includes gentle antihistamines of the 3rd generation, among which Cetrin is widely used. The active components are devoid of cardiotoxic sedative effect, have high selectivity, and are not addictive. Is it possible to drink Cetrin during pregnancy, and in what doses/course, so as not to harm the health of the baby and mother?
The advisability of taking Cetrin at different stages of gestation
The drug is presented on the pharmacological market syrup and tablets, coated with a multicomponent soluble coating. Regardless of the form of release, the main composition is formed by the competitive histamine antagonist - cetirizine.
H1 histamine receptor blocker exhibits antipruritic, antiexudative and antiallergic activity. The therapeutic effect is enhanced by the presence in the composition excipients: corn starch, lactose, povidone KZO.
"Cetrin" relieves the symptoms of an allergic reaction, prevents the development of pathological changes under the influence of antigens. The action of the drug is aimed at inhibiting the synthesis of irritants, reducing leukocyte lineage cells, increasing throughput capillaries.
The components are quickly absorbed into the gastrointestinal tract, the medical effect occurs within an hour after administration, lasts up to 24 hours.
The productivity and safety of Cetrin is explained by the fact that it does not affect serotonin and cholinergic nerve endings. Research that would prove possible harm health of the mother and unborn child have not been carried out on patients.
For reference! The components may be excreted in milk during breastfeeding, therefore antihistamines are prohibited during lactation.
According to the instructions for use of "Cetrina" during pregnancy, the drug is included in the therapeutic regimen at all stages of gestation, when the threat to the health of the mother and child exceeds potential harm from taking medication.
To prevent the risk of side effects must be taken allergic drug according to doctor's recommendations and under medical supervision.
Minimum toxic effects The use of Cetrin in the 2nd trimester has an effect on the fetus. Bookmark internal organs completed, the placenta is formed, the embryo is protected from the effects of the components of the drug.
Contraindications
Due to the fact that the drug is excreted from the body primarily by the kidneys, it is prescribed with caution to patients with a history of renal and liver failure.
For reference! Cetrin is included in the therapeutic regimen for older people in a reduced dosage.
In pediatrics, the pharmaceutical product is approved from the age of six, mainly in the form of syrup. In case of hypersensitivity of the body to individual components or overdose, the development of the following disorders is noted:
- headaches;
- signs of intoxication;
- depression;
- dizziness;
- increased blood pressure, tachycardia;
- tremor of the upper extremities;
- feeling of dry mouth.
"Cetrin" during early pregnancy
After fertilization of the egg, the period of embryo formation begins, which covers the first 13 weeks. At this time, the formation of organs and systems occurs. Proliferating fetal cells are sensitive to external factors impact.
Use of pharmacological products in early gestation is fraught with serious pathological disorders.
A weak placental barrier does not provide any hope of protection from the penetration of medicinal components, as a result - the development of fetal hypoxia and spontaneous termination of pregnancy.
The ability of an antihistamine to affect the fetus is determined by physiological characteristics patient and placenta condition, course and dosage.
Contraindications for Cetrina during pregnancy in the 1st trimester indicate an increased likelihood of side effects, but this does not mean that pathological changes characteristic of each clinical case.
Therefore, to prevent the risk of defectiveness of the unborn child, it is advisable to take increased care of your health and that of the baby in order to eliminate the need for drug treatment.
Directions for use and dosage
The tablet form of the antiallergic product has become widespread in ENT practice. 1 tablet contains 10 mg. cetirizine dihydrochloride. This is a one-time rate for adults. With reduced renal function, the dose is halved - half a tablet (5 mg). The daily frequency is limited to two doses.
For reference! For chronic renal failure, Cetrin is prescribed 5 mg. in one day.
Duration drug regimen determines the form of the lesion, the etiology of the pathogen, the general course clinical picture. For preventive purposes, the course of use varies from 2 weeks to a month.
IN therapeutic purposes prescribed a cycle from 14 days to six months. Medicinal effect persists for the next 3 days after discontinuation of the drug.
The digestion process does not slow down the absorption period active ingredients, therefore, it is allowed to take tablets before or after meals with plenty of water.
The regimen for taking the liquid form is no different from the previous variation. From the age of twelve, 10 ml is prescribed. syrup twice a day, provided there is no pathological disorders from the kidneys.
Conclusion
Before using Cetrin, it is recommended to study the instructions to prevent the development of side effects. The 3rd generation antihistamine exhibits high therapeutic effect in a gentle form for conjunctivitis, hay fever, dermatosis, in complex therapy for bronchial asthma.
Minimal development risks side effects from the use of the drug are observed in the 2nd trimester of pregnancy. Therefore, early and late dates are contraindications for use.
Cetrin is medicine antihistamine action 3rd generation. It is used to combat allergic reactions in patients of different ages. IN this moment this is the most effective and safe drug against allergies. Below is an abstract of Cetrin and instructions for its use.
Name: Tsetrin
Dosage: The syrup is available in bottles of 30 and 60 ml. The weight of one tablet is 10 mg, one blister contains 10 tablets, and each cardboard pack contains 2 or 3 blisters.
Release form: coated tablets or syrup.
Impact group: drug for the respiratory system
Pharmacological group: antihistamine. Use orally.
Properties of the drug
Cetrin blocks H1-histamine receptors, providing an antiallergic effect. The drug does not block serotonin and cholinergic receptors.
At correct use does not cause disorders nervous system and drowsiness. Thanks to the active ingredient Cetirizine, the product effectively relieves allergy symptoms in early and early stages. late stage, and also reduces the migration of blood cells (basophils and neutrophils). Cetrin can not only quickly relieve allergy symptoms, but also prevent its occurrence.
Pharmacological properties of Cetrin tablets also include:
- Reduces smooth muscle spasm and delays the onset of edema
- Reduced capillary permeability
- Elimination of skin reactions to allergens (for example,)
- Reduced manifestations bronchial asthma
In most patients, improvement occurs within 60 minutes after taking the drug. Five percent of patients noticed the positive effect of the drug within twenty minutes after use. The duration of action is more than 24 hours. It is not addictive even after a long course of therapy, and after completion of treatment the drug continues to act for 72 hours.
Main components and release form
Cetrin tablets contain lactose, corn starch, sorbic acid, magnesium stearate, dimethicone, titanium dioxide, hypromellose, talc, povidone, polysorbate and macrogol as excipients. Each tablet contains 10 mg of the active substance cetirizine dihydrochloride. The tablets have a round convex shape and are coated with a white coating. average price per drug ranges from 140 to 220 rubles.
Cetrin syrup is often colorless, sometimes slightly yellowish, of a uniform structure with a pronounced fruity odor. One milliliter of syrup contains 1 mg of cetirizine. Additional components are purified water, glycerol, sucrose, disodium edetate, benzoic acid, sodium citrate, sorbitol solution and fruit flavor. The cost of syrup is approximately 130 rubles.
Analogues of the drug are Zetrinal, Zirtec, Zodak, Parlazin, Analergin. All of them are released in various forms(tablets, drops and syrups).
Features of application
Cetrin for children in syrup and in tablets for adults is equally well absorbed in the digestive organs. The drug can be taken with food, and the maximum content active ingredients The blood level of the medication occurs within an hour after administration.
The half-life of the drug from the body is 10 hours, but may increase by half in older people and people with liver problems. In children, the drug is excreted longer (from two years - 3 hours, 2-5 years - 5 hours, up to 12 years - 6 hours). The drug is mainly excreted in the urine, and only a small part of it is excreted during bowel movements. Cetrin tends to penetrate and accumulate in breast milk.
Cetrin is prescribed for the treatment of allergies in the following cases:
- Seasonal or chronic conjunctivitis and rhinitis
- For treatment atopic dermatitis and for dermatoses accompanied by itching.
- To remove skin itching, urticaria, etc.
- For hay fever, accompanied by sneezing, itching and increased tear production, as well as during atopic bronchial asthma.
Cetrin tablets for the treatment of adults and children over six years of age ( daily norm– 10 mg/1 tablet):
- Adults: 1 tablet per day
- Children over 6 years: half a tablet twice a day
- Patients with kidney disease reduce the standard dosage by half.
The medicine should be taken with water.
Cetrin syrup is best taken in the evening, but the drug can be taken at any time of the day, regardless of food. The syrup should be washed down with water.
- Children over six years of age and adults: 10 ml (2 scoops) of syrup once a day. If necessary, the dosage is divided into two doses.
- Children 2-6 years old, people with kidney disease: 5 ml once a day or 2.5 ml twice a day.
The dosage of syrup directly depends on the child’s weight. Children up to 30 kg are prescribed one scoop of the product, and those weighing more than 30 kg - 10 ml or 2 scoops.
Side effects
In most patients, Cetrin does not cause side effects. But in some cases, the following adverse effects may occur:
- Central nervous system disorders: headache, migraine, general weakness, increased drowsiness, nervous excitement, dizziness.
- Digestive organs: pain and discomfort in the abdomen, dry mouth,.
- Hives, itching, swelling and other manifestations of allergies occur less frequently.
With a severe overdose of the drug (exceeding the therapeutic norm by 30-40 times), they appear brightly severe symptoms allergies: rash, itching, tachycardia and dry mouth. Exceeding the dose may also be accompanied by urinary retention, constipation, increased weakness and fatigue and trembling of the limbs.
To eliminate the consequences of an overdose, gastric lavage is performed, and if in serious condition The patient is given additional symptomatic therapy.
Cetrine and pregnancy
The drug was not observed during testing negative impact Cetrina for fruit. However, insufficient research possible risks for the fetus makes Cetrin unsuitable for use during pregnancy and lactation.
Main contraindications
Patients with liver failure It is recommended to use Cetrin in limited quantities and only after the dosage has been prescribed by a doctor. Children under one year of age and elderly patients are recommended to use the product only when emergency and with great caution. Contraindications to the drug also include:
- Pregnancy and lactation
- Individual intolerance or increased sensitivity to the components of the medicine
- Children under two years of age (syrup), children under six years of age (tablets).
Use with other medications
Studies have shown that Cetrin does not interact with the following drugs: glipezide, diazepam, ketoconazole, cimetidine and analogues. Simultaneous use Cetrona and theophylline reduces antihistamine effect Cetrona. The drug should be taken with caution along with sedatives.
Knowing exactly what Cetrin tablets are prescribed for, you can avoid a negative reaction from the body. If the dosage is observed, the drug does not enhance the effect of ethanol, but simultaneous consumption of alcohol is still not recommended.
Cetrin syrup, according to research, does not affect the speed of reaction, but if the dosage is exceeded (10 mg per day), it slows down psychomotor activity. Therefore, Cetrin is prescribed with caution to patients working with machinery, in transport or in production that requires high concentration attention.
During pregnancy, women experience worsening chronic diseases, sores “wake up” that have not reminded of themselves for a long time. Allergies are no exception, the symptoms of which may be more pronounced during pregnancy. One of the main symptoms of allergies is rhinitis. It can manifest itself not only with a runny nose, nasal congestion, but also with itching and other symptoms. Women are often prescribed antihistamines to reduce symptoms. Among them is Cetirizine, the instructions for use of which we will now reveal.
In the instructions for the drug, as well as in numerous articles on the Internet devoted to this drug, you can find that it is contraindicated during pregnancy. However, it is often prescribed for allergies in pregnant women if the benefits are greater than the possible risks. In the 90s of the last century, several studies were conducted, during which it turned out that the use of this drug even in the first trimester of pregnancy is acceptable.
However, all the same, this is an antihistamine, the use of which carries risks. Therefore, it is officially prohibited to take it during pregnancy and lactation.
Instructions for use of the drug
According to the instructions for use of Cetirizine tablets, the daily dosage for an adult is 10 mg. You can take them at once or divide them into 2 doses of 5 mg. During pregnancy, the dosage can be adjusted individually, depending on the severity of allergy symptoms. This is all determined by the doctor, as well as the duration of the course of treatment.
In general, pregnancy itself is a contraindication to the use of this drug.. But, as with most other drugs, in practice they are prescribed to pregnant women. In the vast majority of cases, no side effects or serious complications occur. Although, everything is individual and only the doctor decides in each case, it is worth prescribing this drug, or not. The drug should be prescribed with caution to women with chronic renal failure.
How much do tablets, drops and analogues cost?
How much Cetirizine will cost depends on the form of release, the number of tablets or volume, dosage, country and manufacturing company. For example, a package of Cetirizine with 30 tablets of 10 mg each, produced in Russia, costs 152-190 rubles. The cost of a package of 20 tablets in the same dosage, but already produced in Macedonia, will cost 80-100 rubles. A package of the drug from a Vietnamese manufacturer with 10 tablets of 10 mg each will cost 70-80 rubles. Swiss drops of Cetirizine in a volume of 20 ml will cost 250-270 rubles.
As for Cetirizine analogues, their cost is as follows:
- Tsetrin - 162 rubles
- Zodak - 147 rubles
- Zyrtec - 319 rubles
It must be remembered that not all analogues of the drug can be taken during pregnancy, in particular, the drug Loratadine can be found in the pharmacy; its use is possible only in extreme cases when the life of the expectant mother is in danger. But all this must be discussed with your doctor so that no problems arise.
Hello friends! Today I want to tell you about the drug Cetrin, whose indications for use promise to cope with allergies.
It's no secret that there are a lot of medications that stop allergic attacks, but I want to talk about this remedy: its advantages and disadvantages.
In the next article, by the way, you can read what they are prescribed for.
Cetrin indications for use
First, I consider it necessary to write 2 medical facts:
- Any irritants that get inside are met with powerful resistance from immune cells.
- There are situations when the immune system weakens and then control over the production of histamines disappears: they begin to form in huge quantities, and have a detrimental effect on all human tissues and organs.
Antihistamines come to the rescue in such situations. Today at clinical practice enjoy antihistamines three generations. The first generation includes:
- tavegil,
- fenistil,
- diazolin
Reading the indications for the use of each of them, one can come to the conclusion that they all have a powerful suppressive effect.
But, unfortunately, this affects the manifestation no less severe side effect - drowsiness .
Third generation medications (Claritin, Telfast, Erius) have the same strong qualities in suppressing histamine production, and are practically free of side effects.
What specific indications for use do Cetrin have?
It belongs to the second generation of antihistamines and has more wide range actions. It does not have a very pronounced side effect, but it also has a gentler effect on the receptors.
Active substance - cetirizine, binds to receptors and prevents histamine from reaching them. This means that such allergic manifestations How:
- Hyperemia,
- Rash,
- Itching.
Moreover, this already happens at the cellular level. In addition, it does not allow inflammation to accumulate at the site, and, accordingly, prevents the development inflammatory process at the site of an allergic reaction.
Due to these qualities and indications, it can be prescribed for the treatment of allergies not only in adults, but also in children over 2 years of age.
Let's now try to figure out what the indications for use say about pregnancy...
Cetrin during pregnancy
Before we talk about the possibility of its use during pregnancy, I want to tell you why, in general, antihistamines are prohibited for expectant mothers.
During pregnancy, histamine becomes a very necessary component. With its assistance, the fertilized egg attaches to the wall of the uterus.
It promotes the development of the embryo, and subsequently regulates the metabolism of the fetus. The formation of the baby’s tissues and organs depends on it.
Important to remember!
Taking medications that suppress the production of histamine can have a tragic effect on the child’s condition, physical and mental development.
Here are the indications for use of Cetrin during pregnancy:
if you start using it, it may negatively affect the functioning of your kidneys and liver. Therefore, tsetrin during pregnancy, of course, has advantages over other drugs, but is used with great caution.
It is MANDATORY that you need to consult with a specialist in your area, and then, if you are allowed to use it, do so under the strict supervision of a doctor.
The drug has few side effects and does not affect the quantitative production of histamines.
But, nevertheless, during the first 12 weeks its use is generally prohibited. And in the future, doctors look at the health status of the mother and fetus.
It is also worth mentioning that the medicine is produced by an Indian pharmacological company, but are there any analogues in domestic production?
Cetrin analogues
Comparing the indications for use of Cetrin and looking through reference books, I discovered a number of domestically produced medications that are similar in their effects.
All dosage forms, produced on the basis of cetirizine, and which are histamine blockers can be considered analogues.
Therefore, here are analogues of cetrin:
- Fesco tablets,
- Cereza,
- Ketotifen,
- Clarifer,
- Xizal,
- Telfast.
- Clargotil syrups,
- Claridol,
- Loratadine,
- Peritol.
If we compare in general the indications for the use of some other drugs, which are sometimes called “synonyms,” this is another separate list.
This includes all medications based on cetirizine, with slightly different additional components.
- Alerza,
- Cetirizine,
- Letizen,
- Zyrtec.
The list can be continued for a very long time. Now, knowing what it has Cetrin indications for use you have to decide: do you want to start using it?
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