Among modern antibiotics there are enough especially powerful and effective drugs, which in some cases can save an animal’s life. Unfortunately, not all of them are affordable, and you can’t buy them in pharmacies without a prescription. Well-known and quite effective means, one of which is Gentamicin.
The drug, despite being somewhat anachronistic, is in fairly high demand in veterinary medicine. It belongs to the group of aminoglycoside antibiotics, synthesized in the last century. Important distinctive feature this medicinal product is its specificity: it acts only on gram-negative microorganisms; it is practically useless to treat infections caused by gram-positive microflora.
That is why Gentamicin for dogs should never be used by eye. This medicine can be injected only in cases where the pathogen and the degree of its sensitivity to the drug are precisely known. This can only be determined by growing a culture from the pathological material taken (smears, etc.).
Can be used in the treatment of joint diseases(arthritis and arthrosis), as well as in cases acute respiratory diseases of the upper and lower respiratory tract . Note that the drug has shown itself well both in the treatment of primary infections and in the elimination of secondary pathologies that appeared against the background of ailments of viral etiology.
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Good results have been obtained in the treatment of many diseases gastrointestinal tract if the pathogen belongs to gram-negative microflora. 90% of the medicine is excreted by the kidneys, so it is also used in the treatment of diseases of the excretory tract, although theoretically this cannot be done with dogs (see below).
Toxic effects and precautions
On veterinary websites, if you wish, you can find a huge list of cases in which the drug we are describing proved to be far from successful. the best side. Often severe side effects are the result of its illiterate use. We would like to remind you of those aspects that should always be kept in mind when planning to treat an animal with gentamicin. The pronounced toxic effects of the drug do not appear out of nowhere:
- Under no circumstances should Gentamicin be used on animals if the pet has any kidney problems. For cats, this antibiotic can be used to treat urinary tract, but in the case of dogs it is strongly not recommended to do this.
- Never use this drug if the animal is already receiving other aminoglycosides or any other antibiotics. Especially in this regard, cephalosporins, which are widespread today, are dangerous. In tandem with gentamicin, they form many very toxic compounds that have a severe impact on the kidneys and liver. IN severe cases possible development of acute renal And .
- This type of antibiotic never used simultaneously with muscle relaxants(that is, substances that promote muscle relaxation).
- Also strictly its simultaneous use with diuretics is prohibited(especially with furosemide).
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Sometimes you have to directly violate the manufacturer’s recommendations and use the medicine in combination with other drugs. In this case, the administration of gentamicin must be supervised by an experienced veterinarian. If any negative signs antibiotic use is abruptly stopped to avoid severe consequences for the animal's body.
Attention! Using this drug for more than 7-8 days may also cause severe damage. nervous system and, in particular, auricular nerve. Even if the dog survives, its hearing will be irreversibly damaged. Do not neglect the recommendations given by your veterinarian!
Positive and negative trait of this drug is a sharp increase in its concentration in all biological fluids and tissues immediately after administration (within an hour) and high penetrating ability. Thus, the medicine easily penetrates into the abdominal and chest cavity, which is very valuable in the treatment of peritonitis and pleurisy. But at the same time, the drug just as easily passes through the placental barrier, and therefore it is prescribed to pregnant animals only in the most extreme cases. The fact is that the drug can have extremely Negative influence on the state of the nervous system of the fetus, which will lead to the birth of underdeveloped, non-viable offspring.
One more note about toxic effects. Under no circumstances should the medicine be administered simultaneously with chloramphenicol! This is fraught with extremely serious consequences. In addition, it is better to avoid in every possible way its simultaneous administration along with all penicillins, erythromycin, and all sulfonamides. With extreme caution, it is administered simultaneously with drugs that impair blood clotting (heparin). Finally, Gentamicin injections are incompatible with the prescription of multivitamin complexes that contain at least one vitamin from group B.
Instructions for use of gentamicin sulfate solution 4%
for treating animals with diseases bacterial etiology
(developer organization: CJSC NPP "Agropharm", Voronezh)
I. General information
Trade name of the drug: Gentamycin sulfate solution 4% (Solutio Gentamycini sulfas 4%).
International generic name: gentamicin sulfate.
Dosage form: solution for injection.
Gentamicin sulfate solution 4% as active substance 1 ml contains gentamicin sulfate (in terms of gentamicin base) - 40 mg, as well as Excipients: sodium pyrosulfite - 3.2 mg, Trilon B - 0.1 mg and water for injection - up to 1 ml.
By appearance the drug is a clear liquid from colorless to slightly yellow.
A solution of gentamicin sulfate 4% is produced packaged in 10 and 100 ml glass bottles of neutral glass of appropriate capacity, sealed with rubber stoppers reinforced with aluminum caps.
The solution is stored in the manufacturer's sealed packaging in a dry, dark place, separate from food and feed, at a temperature of 5°C to 25°C.
The shelf life of the medicinal product, subject to storage conditions, is 2 years from the date of production.
After opening the bottle, unused medicinal product cannot be stored.
It is prohibited to use the medicinal product after the expiration date. Store in places inaccessible to children.
Unused medicinal product is disposed of in accordance with legal requirements.
II. Pharmacological properties
Gentamicin sulfate solution 4% belongs to the antibacterial drugs from the group of aminoglycoside antibiotics.
Gentamicin sulfate is a mixture of several antibiotics produced by Micromonospora purpurea, has wide range antimicrobial action, active against most gram-positive and some gram-negative microorganisms, including Proteus, Escherichia, Salmonella and Staphylococcus.
The antibiotic does not work on anaerobic bacteria, fungi, viruses and protozoa.
The mechanism of the bactericidal action is due to the binding of the antibiotic to the 30S subunit of ribosomes and disruption of protein synthesis, thereby preventing the formation of a complex of transport and messenger RNA, which results in erroneous reading of RNA and the formation of non-functional proteins. In high concentrations it reduces barrier functions cytoplasmic membranes and causes the death of microorganisms.
Gentamicin sulfate for intramuscular injection quickly absorbed from the injection site into the blood and penetrates into most organs and tissues of the body. Maximum concentration The antibiotic in the blood is achieved after 1 hour, the therapeutic concentration in organs and tissues is maintained for 8-12 hours. Gentamicin is excreted unchanged by the kidneys, creating high concentrations in the urine.
A solution of gentamicin sulfate 4% in terms of the degree of impact on the body, according to GOST 12.1.007, is classified as a low-hazard substance (hazard class 4), and in recommended doses does not have a local irritant effect.
III. Application procedure
Gentamicin sulfate solution 4% is used for the treatment of respiratory and gastrointestinal diseases, sepsis, pneumonia, pleural empyema, peritonitis, meningitis, pyelonephritis, cystitis and other animal diseases caused by antibiotic-sensitive microorganisms.
A contraindication to the use of gentamicin is the increased individual sensitivity of the animal to the drug. The use of the drug is prohibited for inflammation of the auditory nerve, severe violations kidney function, during pregnancy the drug is prescribed with caution (under the supervision of a veterinarian).
A solution of gentamicin sulfate 4% is used intramuscularly twice a day with an interval of 10-12 hours in the doses indicated in the table (based on mg of active substance per 1 kg of animal weight):
The maximum volume of solution for administration to one site in cattle and horses should not exceed 15 ml, in pigs - 10 ml, in dogs and cats - 2.5 ml.
The main symptoms of overdose are associated with the effect of gentamicin on the central nervous system (damage to the cranial nerves and associated disturbances in the functioning of the vestibular and hearing aid). In these cases, the drug is discontinued and symptomatic medications are prescribed to the animal.
Features of the action upon first use of the drug and upon its withdrawal have not been established.
You should avoid skipping the next dose of the drug, as this may lead to a decrease in its therapeutic effectiveness. If one dose is missed, the use of the drug is resumed at the same dosage and according to the same regimen.
When using the drug in accordance with this instruction side effects and complications in animals, as a rule, are not observed. In some animals, edema may develop at the injection site, which resolves spontaneously within 1-2 days. In rare cases, the animal may experience allergic and ototoxic reactions, vomiting and drowsiness. In these cases, the drug is discontinued and the animal is prescribed symptomatic medications.
Simultaneous or sequential use of gentamicin with other oto- and nephrotoxic drugs (streptomycin, kanamycin, neomycin), as well as mixing the drug in the same syringe with other drugs is not allowed.
Slaughter of animals for meat is permitted no earlier than 21 days after the last use of Gentamicin Sulfate 4% Solution.
Meat from animals forcedly killed before the expiration of the specified period can be used as feed. fur animals.
Milk from dairy animals is allowed to be used for food purposes no earlier than 72 hours after the last administration of the drug. Milk obtained earlier than the established period can be used after boiling as animal feed.
IV. Personal prevention measures
When conducting therapeutic measures with the use of Gentamicin sulfate solution 4% should be observed general rules personal hygiene and safety precautions provided for when working with medicines. While working with the drug, do not drink, smoke or eat. Hands should be washed after finishing work warm water with soap.
People with hypersensitivity to aminoglycoside antibiotics should avoid direct contact with the drug solution. In case of accidental contact with skin or mucous membranes, they must be washed with running water and soap. If allergic reactions occur or if the drug accidentally enters the human body, you should immediately contact medical institution(bring with you the instructions for use of the drug or the label).
Empty bottles must not be used for household purposes and must be disposed of with household waste.
Manufacturer: CJSC NPP "Agropharm", Russia, 394087, Voronezh region, Voronezh, st. Lomonosova, 114-6.
With the approval of this instruction, the instructions for the use of Gentamicin Sulfate Solution 4% for the treatment of animals with diseases of bacterial etiology, approved by Rosselkhoznadzor on June 29, 2006, become invalid.
INSTRUCTIONS
on the use of Gentamicin sulfate 4% solution for injection
for the treatment of animals with bacterial infections
(Organization- developer : LLC Firm "BioChemPharm", Vladimir region, Raduzhny)
I . General information
1. Gentamicin sulfate 4% solution for injections (Gentamycini sulfas 4% injectionibuss olutio pro) is a medicine intended for the treatment of farm animals, dogs and cats with diseases of bacterial etiology.
2. Gentamicin sulfate 4% injection solution as an active ingredient in 1 cm 3 contains gentamicin sulfate - 40 mg, as well as auxiliary components: sodium pyrosulfite, disodium salt of ethylenediamine tetraacetic acid (Trilon B) and water for injection.
3. In appearance, the drug is a sterile transparent yellowish color solution. 4. Gentamicin sulfate 4% solution for injection is produced in packages of 5; 10; 20; 50 and 100 cm 3 in glass, sterile bottles of appropriate capacity, sealed with rubber stoppers reinforced with aluminum caps. Each bottle is labeled indicating: the manufacturing organization, its address and trademark, the name, purpose and method of use of the medicinal product, the name and content of the active substance, the volume in the bottle, the inscriptions “For veterinary use " and "Sterile", series numbers, production dates, expiration dates, storage conditions, state registration numbers, information on confirmation of conformity, designations of specifications and provide instructions for use. Store the medicinal product in the manufacturer's sealed packaging in a dry, dark place, separate from food and feed at a temperature of 5°C to 25°C.The shelf life of the medicinal product, subject to storage conditions in a closed package, is 2 years from the date of manufacture, after opening the bottle - no more than 25 days. It is prohibited to use the medicine after its expiration date.
II . Pharmacological properties
5. Gentamicin sulfate, which is part of the drug, belongs to the group of aminoglycoside antibiotics and is a mixture of several antibiotics produced
Micromonospora purpurea. It has a wide spectrum of antimicrobial action, is active against most gram-positive and some gram-negative microorganisms, including Staphylococcus spp., Streptococcus spp., Salmonella spp., Proteus mirabilis, Escherichia coli. The antibiotic does not affect anaerobic bacteria, viruses, protozoa and fungi.The mechanism of the bactericidal action of the antibiotic is the ability to inhibit the biosynthesis of the cell wall of microorganisms, which leads to its death.
After parenteral administration, the drug is well and quickly absorbed from the injection site and penetrates into most organs and tissues of the animal. The maximum concentration of gentamicin sulfate in the blood serum is achieved after 1 hour and is maintained at a therapeutic level for 8-12 hours. The antibiotic is excreted from the body mainly in the urine, mainly in unchanged form.
When administered orally, the drug is practically not absorbed from the gastrointestinal tract and exerts its effect only in the intestines for 12 hours and is excreted mainly in feces.
6. Gentamicin sulfate 4% injection solution in terms of the degree of effect on the body is classified as moderate hazardous substances(hazard class 3) according to GOST 12.1.00
7.III
. Application procedure7. Gentamicin sulfate 4% injection solution is used in cattle, horses, sheep, pigs, dogs and cats for the treatment of respiratory and gastrointestinal, genitourinary infections, sepsis, pneumonia, pleural empyema, peritonitis, meningitis, pyelonephritis, purulent infections skin and soft tissues and other diseases of bacterial etiology whose pathogens are sensitive to gentamicin.
8. Gentamicin sulfate 4% injection solution is used intramuscularly or orally twice a day with an interval of 10-12 hours in the following doses:
|
Animal species |
Route of administration |
Dose |
Course of treatment (days) |
|
|
DV mg/kg animal weight |
drug ml/10 kg |
|||
| Horses |
intramuscularly |
|||
| Cattle, sheep |
intramuscularly p orally |
0,75 |
||
| Pigs |
intramuscularly p orally |
|||
| Dogs, cats |
intramuscularly |
|||
The maximum volume of solution for administration to one site should not exceed 15 ml for cattle and horses, 10 ml for pigs, 5 ml for sheep, 2.5 ml for dogs and cats.
9. When using Gentamicin sulfate 4% solution for injection in accordance with these instructions, side effects and complications are usually not observed. In rare cases, the animal may develop edema at the injection site, which resolves spontaneously within 1-2 days.
10. Gentamicin sulfate 4% injection solution should not be used simultaneously and sequentially with antibiotics of the penicillin, streptomycin, kanamycin, neomycin group, or mixed in the same syringe with other drugs.
The use of Gentamicin sulfate 4% solution for injection is not allowed in animals with severely impaired renal function.
11. In case of increased individual sensitivity of the animal to gentamicin and the appearance of side effects (refusal of food, vomiting, loss of coordination of movements), the use of Gentamicin sulfate 4% solution for injection is stopped and desensitizing therapy is carried out.
12. Slaughter of animals for meat is permitted no earlier than 21 days after the last use of the drug. The meat of animals forcedly killed before the expiration of the specified period can be used as feed for fur-bearing animals.
Milk from dairy animals is allowed to be used for food purposes no earlier than 72 hours after the last administration of the drug. Milk obtained earlier than the established period can be used after boiling as animal feed.
IV . Personal prevention measures
13. When working with Gentamicin sulfate 4% solution for injection, you should follow the general rules of personal hygiene and safety precautions provided for when working with medicines.
14. It is prohibited to use bottles of medicine for household purposes.
15. Gentamicin sulfate 4% solution for injection should be kept out of the reach of children.
Short description: Gentamicin sulfate 4% – antibacterial drug, belonging to the group of aminoglycosides and having a bactericidal effect. It has a fairly wide spectrum of action and is destructive to most gram-positive pathogens and some gram-negative bacteria (including pathogenic strains of streptococci, staphylococci, proteus, coli and salmonella). However, the drug does not have a negative effect on anaerobic species of microorganisms, protozoa, fungi or viruses. Medicine prescribed to domestic and farm animals for the treatment of respiratory diseases, gastrointestinal tract infections and genitourinary system, which are of bacterial origin and whose pathogens are sensitive to gentamicin. According to the degree of toxic effects, the drug belongs to the group of substances moderately hazardous to animals. In high concentrations it can have nephrotoxic and ototoxic effects.
For whom: Gentamicin sulfate 4% can be used to treat pets (cats and dogs), large and small cattle, pigs, horses.
Leave form: the drug is presented clear liquid without color or with a slight yellowish tint, which is packaged in sterile glass bottles of 5, 10 or 100 ml.
Dosage: Gentamicin sulfate 4% is used only for intramuscular injections or for oral use. Injections are given twice a day. Daily dosage for horses, cats and dogs is 0.6 ml for every 10 kg of weight (this corresponds to 2.5 mg of pure gentamicin per kilogram of weight). Sheep and cattle are given 0.75 ml of solution per 10 kg of body weight per day, and the oral dosage is 2 ml per 10 kg of body weight. For pigs daily dose of the drug for every 10 kg is equal to 1 ml for intramuscular injections and 1.5 ml for oral administration. The maximum volume of solution that can be administered in one injection is 15 ml for large animals, 10 ml for pigs, 5 ml for sheep, and 2.5 ml for dogs or cats.
Restrictions: injection solution should not be used to treat animals that have previously had hypersensitivity reactions to aminoglycoside antibiotics. It is also not used with therapeutic purpose for pregnant or lactating females and individuals with kidney pathology. Slaughter for meat is permitted no earlier than 21 days after the end of treatment. The milk is ready for consumption after three days.
How to give Gentamicin to a cat?
Nowadays, antibiotics are becoming increasingly popular in veterinary medicine. They have become indispensable assistants in the treatment of various diseases. Although it is worth recognizing the fact that most of these drugs cause irreparable harm to the body of four-legged animals. One of these antibiotics is Gentamicin for cats. On the one hand, it destroys harmful bacteria, and on the other, it negatively affects internal organs pet.
Still, let's try to figure out what is more good or harmful from Gentamicin? And how should you take this remedy correctly so that you don’t have to deal with a lot of problems related to your cat’s health?
Characteristics of the drug
Gentamicin is produced only in the form of a solution and is used as an intramuscular injection. As a rule, the product is transparent, but sometimes it can have a slightly yellow color. If you notice even the slightest sediment in the bottle, then you should not inject your beloved cat with this product.
As for the volume, Gentamicin ampoules are available in dosages from 2 to 10 ml. There are also dark glass bottles with a dose of 50 ml. 1 ml contains 40 mg of active substance.
Remarkable is the fact that the medication is well absorbed. Gentamicin will reach its maximum concentration in the body 60 minutes after the injection. In general, the drug will be present in the body of your beloved cat for about 12 hours. The product penetrates into the abdominal cavity especially quickly and easily.
For what diseases is treatment prescribed?
No matter how much you think you know exactly what the cat is sick with, self-treatment This drug is strictly prohibited. Unless, of course, you want the cat to die in your arms. You should definitely visit a veterinarian. Moreover, you can inject Gentamicin into a cat only when it comes to gram-negative bacteria, otherwise this medication will be of no use. And it will be possible to determine the type of bacteria that are present in your cat’s body thanks to a special culture, which will be done by a specialist.
Veterinarians attribute this medical product in the presence of many diseases, which include:
- Various respiratory tract infections.
- Problems urinary system, including nephritis and cystitis.
- Arthritis and arthrosis, which are provoked by the presence of pathogenic microflora in the cat’s body.
- Peritonitis, pneumonia, and other diseases that occur due to gram-negative bacteria.
And remember, injecting a cat with Gentamicin is not an easy task at all, since injections of such a drug are very painful. Therefore, the animal must be held very tightly. To carry out this procedure, you should take an assistant or use a special retainer bag.
The instructions for use of Gentamicin for cats state that the drug is administered carefully, adhering to the established regimen:
- On the 1st day, the drug should be administered at a rate of 1.1 ml per 10 kg of animal weight. Do this procedure 2 times a day.
- On the 2nd and all subsequent days, the dosage of Gentamicin for the cat remains the same, only the drug must be injected once a day.
Some veterinarians administer Gentamicin intravenously to cats using a catheter. But this is a rather complicated procedure and the instructions say nothing about it. Therefore, such injections can only be performed by a top-class professional. To ordinary people or beginners in this business should not perform such a dangerous trick. And the point is not at all that not everyone can install a catheter correctly. It’s just that not everyone will be able to calculate the dosage of the drug and take into account the fact that when intravenous administration Gentamicin penetrates the body almost at lightning speed and easily reaches high concentrations.
Drug overdose
If you do not adhere to the dosage while using this medication or exceed the time limit for using Gentamicin, then an overdose of this drug may occur. Such poisoning may have a negative effect on your hearing and kidneys. pet. He may also experience allergic reaction, which will be accompanied by rash and itching. Problems with the eighth cerebral nerve are also possible.
And most importantly, remember that long-term use of Gentamicin has a very bad effect on the cat’s body. If you use this medication for more than 7 days, severe destructive damage to the kidneys and nervous system may occur. But most often the development of acute renal failure. In most cases, such problems lead to the death of a pet.
In what cases is it prohibited to give the drug?
You should also pay attention to the fact that in some situations it is completely prohibited to give Gentamicin injections to cats. The most common of them include:
- Pregnancy. The drug penetrates the placental barrier very quickly, so it can cause irreparable harm to the baby.
- Lactation period, since Gentamicin sulfate, together with milk, easily penetrates the kitten’s body.
- A non-sterile syringe that contains drug residues, because it is difficult to predict the interaction of this drug with them. As a result, such a compound can cause inflammation and various side effects.
- Having kidney problems.
- Taking a variety of drugs that are nephrotoxic, muscle relaxants and ototoxic medications.
- Greater sensitivity to Gentamicin.
- Very young age. Giving this antibiotic to a newborn kitten is strictly not recommended. And only in very rare cases, with the permission of a specialist, can a solution be administered intravenously at a rate of 2.2 ml per 1 kg of weight. That is, it is necessary to reduce the dose of this medication by 2 times.
As you can see, Gentamicin is quite dangerous medical drug, with whom you should not joke. But still, situations may arise in a cat’s life when he will be simply irreplaceable. Therefore, you should not be afraid of using Gentamicin; the main thing is to strictly adhere to the instructions for using this drug, and also carry out this type of treatment under the supervision of a good professional. Then everything will definitely be just fine for you and your cat.
Gentamicin instructions for use injections for animals
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Gentamicin 4% (gentamicin sulfate) (Mosagrogen)
Packing: 80
Release form: 100 ml
Unit Measurement: bottle
Mode of application: injection
Composition of the drug: a medicinal product containing gentamicin sulfate as an active ingredient
List of animals: Cattle, Pig breeding, Horse breeding, Pets.
I. GENERAL INFORMATION
1. Gentamicin sulfate 4% solution (Gentamicini sulfas 4% solutio).
2. Gentamicin sulfate 4% solution is a medicinal product containing gentamicin sulfate as the active ingredient. 1 ml of the drug contains 40 mg of active substance in terms of gentamicin base and excipients.
3. In appearance, the drug is a colorless transparent liquid.
4. Produced in the form of a solution for injection, packaged in 5, 10, 20, 50 and 100 ml in glass bottles. Each packaging unit is labeled indicating the manufacturer, trademark, name of the medicinal product, volume in ml, content and name of the active substance, batch number, expiration date, storage conditions, method of use, the inscriptions “For animals”, “Sterile” and supplied instructions for use. The drug is stored with caution (list B) at a temperature of 5 to 25oC in a dry place, protected from light. Shelf life at specified conditions storage - 2 years from the date of manufacture.
II. PHARMACOLOGICAL PROPERTIES
5. Gentamicin has a wide spectrum of antimicrobial action and is active against most gram-negative and gram-positive microorganisms, including Proteus, Escherichia, Salmonella and Staphylococcus. The antibiotic does not affect anaerobic bacteria, fungi and viruses.
6. When administered intramuscularly, the drug penetrates well into many organs and tissues. The maximum concentration in the blood is achieved 1 hour after administration. After a single injection, the therapeutic concentration of the antibiotic in the body remains for 8 - 12 hours.
When administered orally, the drug is practically not absorbed from the gastrointestinal tract and exerts its effect only in the intestines for 12 hours.
At parenteral administration Gentamicin is excreted unchanged from the body mainly in the urine, and when administered orally, in feces.
7. Gentamicin sulfate 4% solution according to GOST 12.1.007-76 belongs to hazard class 4 - low-hazard substances.
II. ORDER OF APPLICATION OF THE DRUG
8. Gentamicin sulfate 4% solution is used to treat cattle, pigs, horses, dogs and cats with diseases of bacterial etiology; respiratory and gastrointestinal diseases, sepsis, peritonitis, meningitis, pyelonephritis and other animal diseases caused by antibiotic-sensitive microorganisms.
9. The drug is used intramuscularly or orally twice a day with an interval of 10 - 12 hours in the doses indicated in the table.
Gentamicin
Gentamycine sulfas belongs to the group of aminoglycoside antibiotics. The composition of Gentamicin is a mixture of several antibacterial agents, produced by Micromonospora purpurea. The drug is endowed with a wide spectrum of bactericidal and bacteriostatic effects and is active against the vast majority of known gram-positive and gram-negative forms of bacteria.
Dosage form
The release form of Gentamicin is a sterile solution of 4% and 5% in ampoules or in bottles of 1.0; 2.0; 5.0; 10.0; 20.0; 25.0; 50.0 and 100ml.
Each ml of solution contains 40 or 50 mg of active substance, respectively.
Instructions for use of Gentamicin - annotation in/on each package.
Manufacturer: LEK, Slovenia; MOSAGROGEN, Russia.
Description of the drug
Gentamicin has a wide range of antimicrobial activity against most known bacteria, including Proteus, Escherichia, Salmonella and Staphylococcus. The antibiotic is not effective against anaerobic microorganisms, fungi, viruses and protozoa.
Intramuscular administration of the drug ensures good penetration into all tissues and organs. In the blood, the maximum concentration is reached one hour after application, the therapeutic concentration remains up to twelve hours after application.
When administered orally, the drug is poorly absorbed from the gastrointestinal tract and is active for 12 hours only in the intestines.
It is excreted from the body when administered parenterally mainly in urine; when administered orally, it is evacuated with feces.
Indications for use
Indication for use of Gentamicin is the treatment of diseases caused by drug-sensitive bacteria.
- Respiratory diseases;
- Gastrointestinal infections (salmonellosis, colibacillosis), swine dysentery;
- Sepsis, peritonitis;
- Pyelonephritis;
- Arthritis, polyarthritis;
- Dermatitis.
Contraindications
Contraindications for Gentamicin mainly relate to the complete incompatibility of the drug with other drugs. Gentamicin is prohibited from being used simultaneously with penicillins, other aminoglycoside antibiotics, some cephalosporins, chloramphenicol, polymyxin, colistin, and sulfonamides. In addition, the following are contraindications:
- Renal dysfunction;
- Hypersensitivity to gentamicin;
- During pregnancy;
- Use with other nephrotoxic and ototoxic drugs;
- Use with some anesthetics (halaton);
- Use with muscle relaxants.
Side effects
- Allergy to the components of the drug (fever, skin rash, itching);
- Harmful effects on the fetus (suppression of the function of the eighth cerebral nerve, kidney).
Long-term use of the drug in adult animals causes side effects Gentamicin, manifested in dysfunction of the eighth cerebral nerve.
Instructions for use
Method of use of Gentamicin and dosage:
Gentamicin injection solution is used intramuscularly in the following dosage:
For horses, pigs, large and small cattle, 0.5 ml of Gentamicin per 10 kg is prescribed every 12 hours, calculating 2 mg of the active component per 1 kg of weight twice a day.
Dogs and cats on the day of diagnosis - 1.1 ml of Gentamicin per 10 kg every 12 hours, calculating 4.4 mg of the active component per 1 kg of body weight twice a day. Then 1.1 ml of Gentamicin per 10 kg once a day until the end of treatment.
From the first days of life, newborns are recommended to take half the recommended dose. In this case, the course of treatment is up to 5 days.
Important! Gentamicin solution cannot be used in the same syringe with other drugs.
special instructions
Packing: 80
Release form: 100 ml
Unit Measurement: bottle
Mode of application: injection
Composition of the drug: a medicinal product containing gentamicin sulfate as an active ingredient
List of animals: Cattle, Pig breeding, Horse breeding, Pets.
I. GENERAL INFORMATION
1. Gentamicin sulfate 4% solution (Gentamicini sulfas 4% solutio).
2. Gentamicin sulfate 4% solution is a medicinal product containing gentamicin sulfate as the active ingredient. 1 ml of the drug contains 40 mg of active substance in terms of gentamicin base and excipients.
3. In appearance, the drug is a colorless transparent liquid.
4. Produced in the form of a solution for injection, packaged in 5, 10, 20, 50 and 100 ml in glass bottles. Each packaging unit is labeled indicating the manufacturer, trademark, name of the medicinal product, volume in ml, content and name of the active substance, batch number, expiration date, storage conditions, method of use, the inscriptions “For animals”, “Sterile” and supplied instructions for use. The drug is stored with caution (list B) at a temperature of 5 to 25oC in a dry place, protected from light. Shelf life under the specified storage conditions is 2 years from the date of manufacture.
II. PHARMACOLOGICAL PROPERTIES
5. Gentamicin has a wide spectrum of antimicrobial action and is active against most gram-negative and gram-positive microorganisms, including Proteus, Escherichia, Salmonella and Staphylococcus. The antibiotic does not affect anaerobic bacteria, fungi and viruses.
6. When administered intramuscularly, the drug penetrates well into many organs and tissues. The maximum concentration in the blood is achieved 1 hour after administration. After a single injection, the therapeutic concentration of the antibiotic in the body remains for 8 to 12 hours.
When administered orally, the drug is practically not absorbed from the gastrointestinal tract and exerts its effect only in the intestines for 12 hours.
When administered parenterally, gentamicin is excreted unchanged from the body mainly in the urine, and when administered orally - in feces.
7. Gentamicin sulfate 4% solution according to GOST 12.1.007-76 belongs to hazard class 4 - low-hazard substances.
II. ORDER OF APPLICATION OF THE DRUG
8. Gentamicin sulfate 4% solution is used to treat cattle, pigs, horses, dogs and cats with diseases of bacterial etiology; respiratory and gastrointestinal diseases, sepsis, peritonitis, meningitis, pyelonephritis and other animal diseases caused by antibiotic-sensitive microorganisms.
9. The drug is used intramuscularly or orally twice a day with an interval of 10 - 12 hours in the doses indicated in the table.
|
Kind of animal |
Method of administration |
Dose, ml / 10 kg |
Duration of treatment, days |
|
Cattle |
Intramuscularly | ||
|
Orally | |||
|
Intramuscularly | |||
|
Orally | |||
|
Intramuscularly | |||
|
Dogs, cats |
Intramuscularly |
10. Simultaneous or sequential use of gentamicin with other oto- and nephrotoxic drugs (streptomycin, kanamycin, neomycin) is not allowed. The drug should not be used in cases of severe renal impairment.
11. Slaughter of animals for meat using the intramuscular route of administration of the drug is permitted no earlier than 21 days after the last administration. In case of forced slaughter of animals before the established deadline, the meat can be used as feed for fur-bearing animals or for the production of meat and bone meal.
12. Milk obtained from animals to which the drug was administered intramuscularly is prohibited from being used for food purposes during the treatment period and for 72 hours after stopping the use of the drug. This milk can be used to feed animals.
IV. PERSONAL PREVENTION MEASURES
13. When working with Gentamicin sulfate 4% solution, you should follow the general rules of personal hygiene and safety precautions provided for when working with medicinal products for animals.
14. Do not use Gentamicin sulfate 4% solution after its expiration date.
15. Gentamicin sulfate 4% solution should be stored out of the reach of children and animals.
Registration number PVR -2-1.9 / 00147 
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