Betadine mouth rinse. Instructions for use of betadine solution - composition, indications, side effects, analogues and price. International nonproprietary name

Antiseptic drug with a broad spectrum of antimicrobial action against bacteria, some viruses, fungi and protozoa. Upon contact with the skin and mucous membrane, iodine is gradually released and has a bactericidal effect.
Iodine reacts with oxidizable groups of amino acids that are part of the enzymes and structural proteins of microorganisms, inactivating or destroying these proteins. The action develops in the first 15-30 s, and the death of most microorganisms in vitro happens in less than 1 minute. In this case, iodine becomes discolored, and therefore the saturation changes Brown is an indicator of its effectiveness.
When a complex is formed with the polyvinylpyrrolidone polymer, iodine largely loses the local irritating effect characteristic of alcohol solutions of iodine, and therefore is well tolerated when applied to the skin, mucous membranes and affected surfaces.
Due to the mechanism of action, resistance to the drug, including secondary resistance, does not develop with long-term use.
Prolonged application of the drug to large wound surfaces or severe burns, as well as to mucous membranes, can lead to the absorption of a significant amount of iodine. As a rule, due to long-term use of the drug, the concentration of iodine in the blood quickly increases. Concentration returns to entry level 7-14 days after the last use of the drug.
The absorption and renal excretion of povidone-iodine depends on its molecular weight, and since it ranges from 35,000-50,000, retention of the substance in the body is possible. It is excreted from the body mainly by the kidneys. The volume of distribution is approximately 38% of body weight, the half-life after vaginal use is about 2 days. Typically, the level of total iodine in blood plasma is approximately 3.8-6.0 μg/dL, and inorganic iodine - 0.01-0.5 μg/dL.

Indications for use of the drug Betadine

Solution:

• hand disinfection and antiseptic treatment of mucous membranes, for example before surgical operations, gynecological and obstetric procedures, catheterization Bladder, biopsy, injections, punctures, blood drawing, as well as first aid in case of accidental contamination of the skin with infected material;
• antiseptic treatment of wounds and burns;
• hygienic and surgical disinfection of hands.

Ointment:

• prevention of infections in minor cuts and abrasions, minor burns and minor surgical procedures;
• treatment of fungal and bacterial infections skin, as well as infected bedsores and trophic ulcers.

Suppositories:

• acute and chronic vaginal infections (colpitis): mixed infections; nonspecific infections ( bacterial vaginosis, Cardnella vaginalis, trichomonas infection, genital herpes);
• fungal infections (including those caused by Candida albicans) due to treatment with antibiotics and steroid drugs;
• trichomoniasis (if necessary, carry out combined systemic treatment);
• preoperative and postoperative treatment for transvaginal surgical interventions, as well as during obstetric and diagnostic procedures.

Use of the drug Betadine

Solution
The drug is intended for external use in diluted and undiluted form. The drug should not be diluted hot water. Only short-term heating to body temperature is permissible.
The undiluted solution is used to treat hands and skin before surgical operations, catheterization of the bladder, injections, punctures, etc.
Solutions can be used 2-3 times a day.
Hygienic hand disinfection: 2 times 3 ml of undiluted solution - each dose of 3 ml is left on the skin for 30 s.
Surgical hand disinfection: 2 times 5 ml of undiluted solution - each dose of 5 ml is left on the skin for 5 minutes.
To disinfect the skin, the undiluted solution is left after use until it dries.
According to the above according to the solution can be used after dilution tap water. During surgical operations, as well as during antiseptic treatment of wounds and burns, an isotonic solution should be used to dilute the drug. sodium solution chloride or Ringer's solution.
The following dilutions are recommended:

The solution should be diluted immediately before use.

Ointment
The drug is for local use.
To treat infection: apply 1-2 times a day. The duration of treatment is no more than 14 days.
To prevent infection: apply 1-2 times a week as long as necessary. The affected skin surface should be cleaned and dried, and a thin layer of ointment should be applied. A bandage can be applied to the skin treated in this way.
Suppositories
The suppository is removed from the shell and, after moistening, inserted deep into the vagina.
During the treatment period, the use of sanitary pads is recommended.
Dosage: One vaginal suppository is inserted deep into the vagina in the evening before bed. The drug should be used daily (including during menstruation).
In case of insufficient effectiveness, the course of treatment can be continued, and the dose can be increased to 2 vaginal suppositories daily. The duration of treatment depends on the results of therapy, usually it is 7 days.

Contraindications to the use of the drug Betadine

Hypersensitivity to iodine or other components of the drug, hyperthyroidism, adenoma or dysfunction thyroid gland(nodular colloid goiter, endemic goiter and Hashimoto's thyroiditis), dermatitis herpetiformis Dühring, condition before and after treatment or scintigraphy using radioactive iodine, renal failure, pregnancy and lactation, age up to 1 year.

Side effects of the drug Betadine

Allergic skin reactions - itching, hyperemia, rash (contact dermatitis with the formation of psoriasis-like elements). In some cases, generalized acute reactions with a decrease in blood pressure and/or suffocation (anaphylactic reactions). In some cases, iodine-induced hyperthyroidism has been observed in predisposed individuals.
Application of povidone-iodine to large wounds or severe burns may cause adverse effects, such as changes in serum electrolyte levels (hypernatremia) and osmolarity, metabolic acidosis, impaired renal function up to acute renal failure.

Special instructions for the use of Betadine

The dark brown color of Betadine indicates the effectiveness of the solution; a decrease in color saturation is a sign of a decrease in the antimicrobial activity of the drug. Under the influence of light or a temperature of 40 ° C, the solution decomposes. The antimicrobial effect of Betadine solution is manifested at its pH from 2 to 7.
The use of povidone iodine may reduce the uptake of iodine by the thyroid gland, which may affect the results of some tests (thyroid scintigraphy, protein-bound iodine, diagnostic procedures using radioactive iodine). When planning these procedures in the use of povidone-iodine, it is necessary to take a break of at least 1-4 weeks.
The oxidizing effects of Povidone-iodine can cause corrosion of metals, while plastic and synthetic materials are generally not sensitive to Povidone-iodine. In some cases, a change in color is possible, which is usually restored.
Povidone-iodine is easily removed from textiles and other materials warm water with soap. Stains that are difficult to remove should be treated with ammonia or sodium thiosulfate solution.
During treatment with the drug, breastfeeding should be stopped.
The solution is not intended for oral administration.
During preoperative disinfection of the skin, it is necessary to ensure that no residues of the solution remain under the patient (due to the possibility of skin irritation).
Since the development of hyperthyroidism cannot be excluded, long-term (14 days) use of Povidone-iodine or its use in significant quantities over large surfaces (10% of body surface) in patients (especially elderly) with latent thyroid dysfunction is permissible only after careful comparison of the expected benefits And possible risk. These patients require monitoring to identify early signs hyperthyroidism and proper examination of thyroid function, even after discontinuation of the drug (for a period of up to 3 months).
Long-term use of the drug can cause irritation and sometimes severe skin reactions. If signs of irritation or hypersensitivity appear, application of the drug should be discontinued.
Significant amounts of iodine can cause hyperthyroidism in patients with thyroid dysfunction. Therefore, they are limited in the use of ointment or solution according to the time and area of ​​the skin surface being treated.
If symptoms of hyperthyroidism occur during treatment, thyroid function should be monitored.
High doses of iodine should be avoided in infants and children early age because their skin is highly permeable and they are more likely to be sensitive to iodine, which increases the risk of developing hyperthyroidism. Povidone-iodine should be used in low doses in these patients. If necessary, thyroid function should be monitored.
Particular caution should be taken when using the drug regularly in patients with previously diagnosed renal failure. Regular use of the ointment should be avoided in patients receiving lithium preparations.
Regular use of povidone-iodine during pregnancy and lactation is possible only according to absolute indications and in low doses, since absorbed iodine penetrates the placental barrier and can pass into breast milk.
The level of povidone-iodine in milk is higher than its level in blood serum. Use of this drug may cause transient hyperthyroidism in the fetus and newborn. In these cases, testing of the child's thyroid function may be necessary.
Avoid accidental exposure of the drug to the mouth or gastrointestinal tract, especially in children.

Drug interactions Betadine

The simultaneous use of povidone-iodine and hydrogen peroxide, as well as enzyme preparations, containing silver and tauloridine, for treating wounds or antiseptic drugs, leads to a mutual decrease in effectiveness, and therefore their combined use is not recommended.
Povidone iodine should not be used with mercury preparations due to the risk of formation of alkaline mercury iodide.
The drug can react with proteins and unsaturated organic complexes, so the effect of povidone-iodine can be compensated by increasing its dose. Long-term use of the drug should be avoided, especially on large surfaces, in patients using lithium preparations.

Overdose of the drug Betadine

Acute iodine intoxication is characterized by following symptoms: metallic taste in the mouth, increased salivation, heartburn, pain in the mouth or throat; irritation and swelling of the eyes; skin reactions; gastrointestinal disorders; renal dysfunction, anuria; circulatory failure; laryngeal edema with secondary asphyxia, pulmonary edema, metabolic acidosis, hypernatremia.
Prolonged treatment of burn wounds with significant amounts of povidone-iodine can provoke a violation electrolyte balance or serum osmolarity with impaired renal function or metabolic acidosis.
Treatment: provide supportive and symptomatic therapy under the control of electrolyte balance, kidney and thyroid function.
In case of intoxication caused by ingestion of the drug, immediate administration is indicated. food products containing starch or protein (for example starch solution in water or milk), gastric lavage with 5% sodium thiosulfate solution or, if necessary, intravenous administration of 10 ml of 10% sodium thiosulfate solution at 3-hour intervals. Monitoring of thyroid function is indicated for early detection iodine-induced hyperthyroidism.

Storage conditions for the drug Betadine

Solution: in a place protected from light at a temperature of 5-15 °C.
Ointment: in a dry place at temperatures up to 25 ° C.
Suppositories: in a dry place at a temperature of 5-15 ° C.

List of pharmacies where you can buy Betadine:

• Saint Petersburg

There is a wide range of drugs that have a disinfecting effect. These include the Betadine solution, which is an antiseptic that is used in gynecology, surgery and others. medical fields. Thus, doctors successfully use this drug to treat and prevent many diseases. The main component of the medicine is iodine, therefore the remedy differs wide range impact, which is aimed at combating fungi, bacteria and other harmful organisms. According to reviews, this medicine is characterized by low toxicity, safety and high efficiency. Betadine solution has an antiseptic effect. This product contains, in addition to iodine, polyvinylpyrrolidone. This medicine produces an antiviral, disinfectant, disinfectant and bactericidal effect.

Composition and release format of this medicinal product

Submitted by antiseptic drug They are produced in polyethylene bottles of 30, 120, and 1000 milliliters. The kit includes a special dropper, and, in addition, a screw-on propylene plug with first opening control.

Betadine solution is produced in the form of a brown liquid that has the odor of iodine. Thanks to the composition of the drug, when used in treatment, the maximum therapeutic effect is achieved. Betadine solution 10% contains active and additional components in the form of povidone iodine, disodium hydrogen phosphate, nonoxynol, anhydrous citric acid, glycerol and purified water.

Mechanism of action of the drug

The disinfecting effect of using the Betadine solution according to the instructions can be achieved with the help of iodine released from the complex with polyvinylpyrrolidone. This occurs through contact with human skin and mucous membranes. As a result, the active element of the drug interacts with oxidizable amino acids that are part of the structure of enzymes of proteins and microorganisms. The effect of the drug is to destroy various microbes, a number of viruses, spores and fungi.

After a long course of treatment of wounds and burns, an increased iodine content is observed in the body. The content of this microelement decreases to normal values two weeks after the last use of the medicine. The drug is excreted through the kidneys. In patients with a healthy thyroid gland, an increase in the amount active component does not have any effect on hormonal levels.

Betadine solution for gargling for sore throat is often used.

Indications for use of the drug

The medicinal antiseptic drug is sold without a prescription, but it can only be used as indicated. Otherwise, you can aggravate the disease, and, in addition, worsen your health.

The main diseases for which Betadine solution is prescribed are the following:

• If the patient has bedsores.
• As part of skin disinfection in the presence of microdamages.
• For ulcers, diabetic foot, household burns and wounds.
• For the treatment of burns in the field of traumatology and surgery.
• In the presence of trophic ulcers.
• To disinfect the area of ​​skin in which a catheter, drainage system or probe is installed.
• As part of the treatment of bacterial, viral or fungal skin infections.
• For disinfection of the oral cavity in case of stomatitis.
• In the field of dermatology, this drug is used to avoid the development of severe forms infections.
• In gynecology, this drug is used to treat the mucous membranes immediately before surgery, be it abortion, removal of polyps or erosion.
• In the field of obstetrics, the drug is used as an antiseptic. birth canal.
• In venereology, Betadine is used for trichomoniasis and mycosis.

As a gargle

As the instructions indicate, the Betadine solution is considered effective in the presence of bacterial and viral infections, which affect the throat, and at the same time the oral cavity. For rinsing, use an aqueous solution of iodine. It is often used to treat diseases such as tonsillitis, laryngitis, pharyngitis and the like.

This is confirmed by the instructions for use for the Betadine throat solution.

"Betadine" for the treatment of burns

The presented medicinal product can have a disinfecting effect for the following skin lesions:

• The medicine is used to treat small burns.
• As part of the antiseptic treatment of burn wounds.
• For the treatment of fire-damaged skin.

During therapy you need to be careful, since antiseptic treatment large areas of severely damaged skin can lead to certain consequences:

• Possible negative reactions on the part of electrolyte metabolism.
• A change in osmolarity may occur.
• Metabolic acidosis is likely to develop.
• Possible disturbances in kidney function.

Treatment of wounds with this drug

Wounds of various kinds are often treated with this medication. For example, we are talking about bedsores, abrasions, scratches, cut wounds, superficial dermatoses and so on.

Method of administration and dosage of the medication

In accordance with the instructions for use, Betadine solution can be used concentrated or mixed with cold water(This drug cannot be diluted with hot liquid). When treating wounds and burns, the medicine is diluted with an isotonic sodium chloride solution. You can warm the medicine up to room temperature in hand. This tool apply no more than three times a day. Features of the use of "Betadine" are as follows:

• As an antiseptic for minor wounds, scratches and abrasions, use ten percent povidone-iodine in undiluted form twice daily.
• To disinfect the mucous and skin surfaces before surgical operations, use undiluted medicine twice in a couple of minutes.
• As part of the treatment of complications, use a pure or five percent product three times.
• In case of acne, ulcers on the skin should be treated with a cotton swab dipped in concentrated ten percent povidone-iodine.
• Burns are treated with a ten percent preparation.
• According to doctors, to treat bacterial or fungal dermatitis, the skin should be treated with a one percent solution.
• The effects of IV drips are eliminated with a five percent solution.
• A diluted Betadine solution for gargling is used twice a day.
• Washing of the articular and serous cavities is carried out once a day with a one percent solution.
• To disinfect the skin of newborns, use a 0.1% solution. To treat the navel area, use a ten percent solution.
• In the field of transplantology and ophthalmology, a five percent drug is used.
• Povidone-iodine is used once for hygienic disinfection of the birth canal, and, in addition, for minor gynecological operations.
• Herpes and papillomas are treated with a concentrated product. In this case, hygienic treatment is performed twice a day.
• Before surgery, the patient’s body is wiped with a sponge soaked in Betadine solution.

Special instructions for use of the medicine

There are a number of special instructions prescribed in the instructions for the drug. If you do not adhere to them, side effects and complications of the disease being treated are likely to occur. Here are the following warnings and tips for using an antiseptic drug:

• If a person has problems with the thyroid gland, this medicine can only be used under the strict supervision of a specialist.
• Regular use of Betadine should be especially careful if the patient has chronic renal failure.
• After the drug dries, a colored film usually forms on the skin area. This colored layer, as a rule, remains until the active iodine is completely removed from the body. As soon as the film disappears, the drug ceases its effect.
• The areas of skin and tissue immediately after treatment with Betadine are dark brown in color. Discoloration is very easy to achieve with just soap and water. If stains are difficult to remove, you can use an ammonia solution.
• It is necessary to ensure that bedridden patient no excess solution remained, otherwise this could lead to severe irritation skin.
• If Betadine solution for the throat gets ingested, it is necessary to lavage the stomach with diluted sodium thiosulfate.

Drug interactions

In order to avoid unpleasant adverse reactions and not worsen your health further, you need to know about the combination of Betadine with various medications. For example, there are the following nuances:

• Betadine cannot be combined with medications that contain mercury. This may increase the risk of developing alkaline mercury iodide.
• The disinfectant may react with unsaturated proteins and organic compounds. This effect is usually compensated by increasing the dosage of Betadine.
• Patients undergoing lithium drug therapy are advised to refrain from prolonged treatment with the solution, especially on large affected skin surfaces.
• The interaction of iodine with hydrogen peroxide and enzyme medications may cause a mutual decrease in the effectiveness of the drugs.

Betadine solution for children

The presented disinfectant preparation may have a slightly different effect on the skin of a baby than on an adult patient. Data aseptic agent Under no circumstances should premature babies and newborns be treated, especially in the first month of life. The use of this medication is permitted only on the recommendation of physicians and only in extreme cases immediately after examining the thyroid gland.

Side effects from the drug

If the antiseptic is not used correctly, it can cause the appearance of various unpleasant consequences. If the recommendations given in the instructions are ignored, the following side effects may occur:

• The occurrence of allergies. In this case, skin irritation is likely along with burning, itching, swelling and hyperemia.
• The development of hyperthyroidism, which is chronic disease thyroid gland. This disease is characterized by an increase in the concentration of hormones in the blood in the case of long-term treatment povidone-iodine.
• Presence of serum osmolarity.
• The appearance of electrolyte imbalance and renal failure.
• A generalized reaction with hypotension and, at the same time, attacks of suffocation may occur.

Is the use of Betadine solution always permitted?

Contraindications for use

The drug "Betadine" has a number of contraindications that should not be ignored. Otherwise, health problems cannot be avoided. It must be said that in fact Betadine does not have as many contraindications as other drugs, but they still exist. So, the main limitations for treatment with this drug are as follows:

• Presence of thyroid adenoma.
• Breastfeeding and pregnancy.
• The patient has hyperthyroidism and hypersensitivity to the active and additional ingredients of the drug.
• The presence of Dühring's dermatitis herpetiformis.

Storage conditions

Described medicinal product available in pharmacies without a prescription. The medicinal solution should be stored in a dark and, in addition, in a dry place at a temperature of no more than thirty degrees above zero. The shelf life of this medication is three years.

Analogs

In pharmacy chains you can find a wide range of analogues of the Betadine solution. The most popular of them, and at the same time the most frequently prescribed drugs, are drugs in the form of “Iodixol”, “Iodinol”, “Octasept”, “Iodoflex” and “Betaiodine”.

Now let's move on to reviewing consumer reviews and find out how medical product is actually effective according to patients who have used it for their treatment.

Antiseptic for external and local use

Active substance

Release form, composition and packaging

◊ Solution for local and external use 10% dark brown free of suspended or settled particles.

Excipients: , nonoxynol 9, lemon acid(anhydrous), disodium hydrogen phosphate, sodium hydroxide solution 10% (w/o) (to establish pH), purified water.

30 ml - polyethylene dropper bottle (1) - cardboard packs.
120 ml - polyethylene dropper bottle (1) - cardboard packs.
1 l - polyethylene dropper bottle.

pharmachologic effect

Antiseptic and disinfectant. Released from the complex with polyvinylpyrrolidone upon contact with the skin and mucous membranes, it forms iodamines with the proteins of bacterial cells, coagulates them and causes the death of microorganisms. Has a rapid bactericidal effect on gram-positive and gram-negative bacteria (except Mycobacterium tuberculosis). Effective against fungi, viruses, protozoa.

Pharmacokinetics

At local application Almost no iodine absorption occurs.

Indications

- treatment and prevention wound infections in surgery, traumatology, combustiology, dentistry;

– treatment of bacterial, fungal and viral skin infections, prevention of superinfection in dermatological practice;

- treatment of bedsores, diabetic foot;

— disinfection of the skin and mucous membranes of patients in preparation for surgical interventions, invasive studies (including punctures, biopsies, injections);

— disinfection of the skin around drainages, catheters, probes;

— disinfection of the oral cavity during dental operations;

— disinfection of the birth canal during “small” gynecological operations(including artificial interruption, insertion of an IUD, coagulation of erosion and polyp).

Contraindications

— dysfunction of the thyroid gland (hyperthyroidism);

- thyroid adenoma;

- Dühring's dermatitis herpetiformis;

- simultaneous use of radioactive iodine;

- premature and newborn babies;

- hypersensitivity to iodine and other components of the drug.

WITH caution The drug is used for chronic pregnancy and lactation (breastfeeding).

Dosage

To treat the skin and mucous membranes, a solution of the drug Betadine is used undiluted for lubrication, rinsing or as wet compress.

For use in drainage systems, a 10% solution is diluted 10 to 100 times. The solution is prepared immediately before use; diluted solutions are not stored.

Side effects

At frequent use over a large area of ​​the wound surface and mucous membranes, systemic reabsorption of iodine may occur, which may affect tests of the functional activity of the thyroid gland.

Reactions hypersensitivity to the drug, possible manifestations allergic reaction(hyperemia, burning, itching, swelling, pain), which requires discontinuation of the drug.

Overdose

Data on overdose of the drug Betadine are not provided.

Drug interactions

Betadine is incompatible with others antiseptics, especially those containing alkalis, enzymes and mercury.

In the presence of blood, the bactericidal effect may decrease, but by increasing the concentration of the solution, the bactericidal activity may increase.

special instructions

In case of dysfunction of the thyroid gland, the use of the drug is possible only under the strict supervision of a doctor.

The use of the drug in newborns is possible only if emergency, after studying the function of the thyroid gland.

Caution should be exercised when used regularly on damaged skin in patients with chronic renal failure.

Care must be taken to ensure that no excess solution remains under the patient. Do not heat the solution before use.

A colored film is formed at the site of application, which persists until the entire amount of active iodine is released, which means that the effect of the drug ceases. Coloring on leather and fabrics is easily washed off with water.

Betadine solution- antiseptic and disinfectant drug. Released from the complex with polyvinylpyrrolidone upon contact with the skin and mucous membranes, iodine forms iodamines with bacterial cell proteins, coagulates them and causes the death of microorganisms. It has a rapid bactericidal effect on gram-positive and gram-negative bacteria (with the exception of Mycobacterium tuberculosis). Effective against fungi, viruses, protozoa.

Indications for use

Betadine solution: for hand disinfection, antiseptic treatment surgical field(skin or mucous membranes) before obstetric, gynecological, surgical operations and procedures; catheterization of the bladder, taking a biopsy, performing injections, punctures; antiseptic treatment of burn surfaces and wounds; as first aid when the skin or mucous membranes are contaminated with biological or other infected material; surgical or hygienic hand disinfection.

Mode of application

Betadine solution
Betadine solution is used externally in undiluted or diluted form. Cannot be used to dilute the solution hot water, however, short-term heating to body temperature is allowed. Undiluted Betadine solution is used to treat the surgical field and hands before surgical interventions, injections or punctures, and bladder catheterization. For hygienic disinfection of hand skin: 3 ml of undiluted Betadine solution 2 times, with each 3 ml portion of the drug left on the skin for 30 seconds. For surgical disinfection of hands: 5 ml of undiluted Betadine solution 2 times, with each 5 ml portion of the drug left to contact the skin for 5 minutes. To disinfect the skin: after lubricating with an undiluted solution of Betadine, the drug must dry for the full effect.
Solutions can be used 2-3 times a day.
For the same indications, Betadine solution is used after dilution with tap water. When treating burns and wounds, surgical interventions, Ringer's solution or isotonic (0.9%) sodium chloride solution is used for dilution. Betadine must be dissolved immediately before use.
The following dilutions are recommended:
- for a wet compress - 100-200 ml of Betadine per 1 liter of solvent (1:5 - 1:10);
- for sitz or local baths: 40 ml of Betadine per 1 liter of solvent (1:25);
- for a preoperative bath: 10 ml of Betadine per 1 liter of solvent (1:100);
- For hygienic bath: 10 ml Betadine per 10 liters of solvent (1:1000);
- for douching, irrigation of the peritoneal area, urological irrigation, before the introduction of an intrauterine contraceptive - 4 ml of Betadine per 1 liter of solvent (1:25);
- for irrigation of postoperative or chronic wounds: 5-50 ml of Betadine per 100 ml of solvent (1:20; 1:2);
- for irrigation of the oral cavity, traumatological or orthopedic irrigation: 10 ml of Betadine per 1 liter of solvent (1:100).

Side effects

Allergic reactions on the skin and mucous membranes are possible (hyperemia, itching, rash). Predisposed patients may develop iodine-induced hyperthyroidism. Rarely - acute generalized reactions with suffocation and/or hypotension (anaphylactic reactions). Possible dermatitis with the development of psoriasis-like elements. Application of the drug to large areas for severe burns or wounds may provoke negative reactions from electrolyte metabolism (increased serum sodium levels), metabolic acidosis, changes in osmolarity, impaired renal function (including the possibility of acute renal failure).

Contraindications

:
Contraindications to the use of the drug Betadine solution are: hyperthyroidism; dysfunction or adenoma of the thyroid gland (endemic goiter, colloid nodular goiter or Hashimoto's thyroiditis); the period before or after any procedures (for example, scintigraphy) with the administration of radioactive iodine; Dühring's dermatitis herpetiformis; During pregnancy and breastfeeding; renal failure; age up to 1 year; individual hypersensitivity to iodine or other components of Betadine.

Pregnancy

:
Recommended use Betadine solution during breastfeeding or pregnancy only if available absolute readings and only in small doses. Absorbed iodine penetrates into breast milk and through the transplacental barrier. During lactation, the iodine content in breast milk more than serum indicator, therefore, when using Betadine in pregnant women breast-feeding stop. The use of povidone-iodine by pregnant and nursing mothers can provoke transient hyperthyroidism in the newborn (fetus). It is recommended to examine the child for thyroid function.

Interaction with other drugs

The combination of hydrogen peroxide and Betadine solution for treating wounds, since this negatively affects the effectiveness of both antiseptics. You also cannot use a combination of Betadine with drugs that contain tauloridine, enzymes or silver. When mixed with mercury-containing preparations, alkaline mercury iodide is formed, so this combination is not allowed. The low effectiveness of the drug can be compensated by increasing the dosage, since povidone-iodine reacts with organic unsaturated complexes and proteins. It is not recommended to prescribe Betadine to patients taking lithium-containing drugs. Prolonged use of the drug over large areas of skin and mucous membranes should be avoided.

Overdose

:
Symptoms of acute iodine intoxication: increased salivation, metallic taste in the mouth, pain in the throat or mouth; heartburn, swelling and irritation of the eyes. Possible gastrointestinal disorders, skin reactions, anuria or deterioration in kidney function, laryngeal edema with signs of secondary asphyxia, circulatory failure, hypernatremia, metabolic acidosis, pulmonary edema.
Treatment: symptomatic or supportive measures under the control of thyroid and kidney function, electrolyte balance.
In case of intoxication with iodine accidentally taken orally, urgent gastric lavage (sodium thiosulfate 5% solution) and administration of food rich in protein and starch (for example, a solution of starch in milk) are necessary. If necessary, sodium thiosulfate solution (10 ml of 10%) is administered intravenously at intervals of 3 hours. During treatment, a thorough examination of the functions of the thyroid gland is indicated in order to timely diagnose hyperthyroidism, which can be caused by povidlon-iodine.

Storage conditions

Betadine solution: at a temperature of 5 to 15°C in a dark, dry place.

Release form

Betadine solution: solution for external use 10% in bottles 30; 120; 1000 ml.

Compound

:
Betadine solution
Active substance (in 1 ml): povidone-iodine 100 mg (which corresponds to active free iodine - 10 mg in 1 ml).
Inactive substances: nonoxynol, glycerin, sodium hydroxide, citric disodium phosphate, anhydrous acid, purified water.

Main settings

Name:

BETADINE solution

Betadine is an antiseptic and disinfectant drug for local and external use.

Released from the complex with polyvinylpyrrolidone upon contact with the skin and mucous membranes, iodine forms iodamines with bacterial cell proteins, coagulates them and causes the death of microorganisms.

On this page you will find all the information about Betadine: full instructions as applied to this medicine, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Betadine. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Antiseptic.

Conditions for dispensing from pharmacies

Available without a prescription.

Prices

How much does Betadine cost? average price in pharmacies it costs 450 rubles for suppositories, ointment costs 250 rubles, and the solution can be bought for 300 rubles.

Release form and composition

Betadine is available in the following dosage forms:

• 10% ointment for external use in aluminum tubes of 20 g, one tube in a cardboard box. 1 g of Betadine ointment contains 100 mg of povidone-iodine and auxiliary components (macrogol - 400, 1000 and 4000, sodium bicarbonate and purified water);
• 10% solution for local and external use in dropper bottles of 30 and 120 ml (in cardboard boxes) or 1000 ml (without box). Main active substance the drug is povidone-iodine (100 mg in 1 ml of solution), and the auxiliary components are glycerin, anhydrous citric acid, nonoxynol 9, sodium hydroxide 10%, disodium dihydrogen phosphate and purified water;
• Vaginal suppositories are dark brown in color and torpedo-shaped. One suppository contains 200 mg of povidone-iodine and macrogol 1000 as excipient. The candles are packed in blisters of 7 pieces, in a cardboard pack there are 1 or 2 blisters.

Pharmacological effect

The drug is a complex compound of iodine and polyvinylpyrrolidone (PVP). PVP, an inert synthetic polymer, acts as a carrier. Accordingly, everything pharmacological properties drugs are associated only with iodine, which belongs to the group of halogen antiseptics; The spectrum of action of iodine extends to gram-positive and gram-negative bacteria, fungi, protozoa, treponemes, viruses and acid-fast bacteria.

The bactericidal effect of iodine is explained by its strong oxidizing properties; it actively interacts with the amino acids of proteins, as a result of which the quaternary structure of the protein changes and its catalytic and enzymatic activity is lost. Basically, iodine disrupts the structures of bacterial transmembrane proteins and enzymes that do not have membrane protection. The concentration of active iodine in Betadine is 0.1-1%. Suppositories are made on a water-soluble basis and do not have any irritating effect on the mucous membrane. When applied topically, there is almost no resorption of iodine from the mucous membrane.

Indications for use

Betadine suppositories are used in following cases:

• (as part of combination therapy);
• fungal infections of the vagina resulting from treatment with steroid and antibacterial drugs;
• chronic and acute infections vaginas of a specific and nonspecific nature (vaginitis, bacterial, etc.);
• treatment before and after transvaginal interventions during obstetric and diagnostic procedures.

Betadine ointment has the following indications:

• treatment of bacterial and fungal skin infections;
• treatment of bedsores infected;
• prevention of injury or infection of the skin (for small cuts and abrasions, minor burns and surgical interventions).

According to the instructions, Betadine solution is used in the following cases:

• for disinfection of wounds and burns;
• as first aid in case of contamination of mucous membranes or skin with infected material;
• for antiseptic treatment of the operating room before gynecological, obstetric and surgical procedures and operations;
• for disinfecting hands before taking a biopsy, performing punctures, injections, and bladder catheterization.

Contraindications

The use of this remedy is contraindicated for the following diseases and conditions:

• subject to simultaneous use of radioactive iodine;
• for a child under 1 year of age;
• hyperthyroidism;
• Dühring's dermatitis herpetiformis;
• thyroid adenoma;
• with high sensitivity to iodine, as well as to other components of this remedy.

The use of the medicine for newborns and premature babies is contraindicated. Use with caution when chronic inflammation skin, during pregnancy, as well as during lactation.

Instructions for candles

• At acute vaginitis Prescribe 1 suppository 1-2 times a day for 7 days.
• At chronic and subacute vaginitis– 1 suppository 1 time/day before bedtime for 14 days, if necessary – for a longer period.

Instructions for ointment

For external use only. Apply a thin layer of ointment to the affected skin surface 2-3 times a day. Can be used under occlusive dressings.

Instructions for the solution

To treat the skin and mucous membranes, a solution of Betadine is used undiluted for lubrication, rinsing, or as a wet compress.

For use in drainage systems, a 10% solution is diluted 10 to 100 times. The solution is prepared immediately before use; diluted solutions are not stored.

Side effects

The following are noted side effects suppositories and other forms of release of the drug:

• local manifestations of an allergic reaction to iodine in the form of redness, rash, itching;
• vaginal dysbiosis (with prolonged use of suppositories);
• thyrotoxicosis (with hereditary predisposition).

Overdose

In case of overdose, the following symptoms may be observed:

• Dermatitis and redness of the skin.
• Diarrhea.
• Impaired renal function.
• Intestinal disorders.
• Metallic taste in the mouth.
• Eye irritation and swelling.
• Burning in mouth and throat.
• Pulmonary edema.
• Hypernatremia.

special instructions

1. The use of Betadine may reduce the absorption of iodine by the thyroid gland and distort the results of diagnostic tests (thyroid scintigraphy, determination of protein-bound iodine, radioactive iodine measurements) or interfere with iodine therapy of the thyroid gland. After using the drug Betadine, before carrying out the listed procedures, you should wait a period, the duration of which should be determined by the doctor.
2. Long-term use of Betadine can lead to the absorption of significant amounts of iodine through the skin and mucous membranes. Therefore, after long-term use of suppositories, it is necessary to perform a thyroid function test.
3. The use of Betadine suppositories in childhood It is contraindicated before reaching puberty. Make a decision about the possibility of using the drug in virgins and implement it according to at least, the first administration of the suppository should be done by a doctor.
4. Povidone-iodine contamination may cause false-positive results in some cases. diagnostic studies, for example by detection hidden blood in feces or glucose in urine.
5. Accidental ingestion of suppositories by children should be avoided.

Drug interactions

Prohibited use vaginal suppositories Betadine together with other antiseptics: alcohol, salicylic acid, hydrogen peroxide, etc. This significantly increases the risk of getting a burn on the membranes of the genital organs, and the effectiveness of using both drugs decreases. Unacceptable complex application suppositories with preparations that contain taurolidine, silver, mercury, lithium and enzymes.