Catad_pgroup Regulators of calcium-phosphorus metabolism
Calcium-D3 Nycomed orange - instructions for use
Registration number:
Tradename drug:
Calcium-D 3 Nycomed
Dosage form
Chewable tablets (orange).
Composition per tablet
Active components:
calcium carbonate - 1250 mg (equivalent to elemental calcium - 500 mg) colecalciferol (vitamin D 3) - 5 mcg (200 IU) in the form of colecalciferol concentrate 2 mg.
Auxiliary components:
sorbitol, isomalt, povidone, magnesium stearate, aspartame, orange oil, mono- and diglycerides fatty acids.
Description:
Round, biconvex tablets, uncoated white with orange aroma. May have small inclusions and uneven edges.
Pharmacotherapeutic group:
Calcium-phosphorus metabolism regulator.ATX code: A12AX
pharmachologic effect
A combined drug that regulates the exchange of calcium and phosphorus in the body (bones, teeth, nails, hair, muscles). Reduces resorption (resorption) and increases bone density, replenishing the lack of calcium and vitamin D 3 in the body, necessary for the mineralization of teeth. Calcium is involved in the regulation of nerve conduction, muscle contractions and is a component of the blood coagulation system.
Pharmacodynamic properties
Vitamin D increases the absorption of calcium in the intestine.
The use of calcium and vitamin D 3 prevents an increase in the production of parathyroid hormone (PTH), which is a stimulator of increased bone resorption (leaching of calcium from the bones).
Pharmacokinetic properties
Vitamin D 3 is absorbed in the small intestine. Calcium is absorbed in ionized form in the proximal region small intestine through an active, D-vitamin-dependent transport mechanism.
Indications for use
The drug in dosage form - tablets is not used in children under 3 years of age. Use with caution: pregnancy, lactation period. Use during pregnancy and lactation
The daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D 3.
Hypercalcemia that develops against the background of an overdose during pregnancy can cause mental and mental defects. physical development child.
Vitamin D and its metabolites can pass into breast milk, so it is necessary to consider the intake of calcium and vitamin D from other sources in the mother and child. Directions for use and doses
Adults: for the treatment of osteoporosis - 1 tablet 2-3 times a day, for the prevention of osteoporosis - 1 tablet 2 times a day. For calcium and vitamin D deficiency:
Adults and children over 12 years old - 1 tablet 2 times a day. Children from 5 years to 12 years: 1-2 tablets per day.
Children from 3 to 5 years old - dosage in accordance with doctor's recommendations. The tablets can be chewed or dissolved and taken with meals. Side effect
Allergic reactions, dysfunction gastrointestinal tract(constipation or diarrhea, flatulence, nausea, abdominal pain), hypercalcemia and hypercalciuria (increased calcium levels in the blood or urine). Overdose
Overdose symptoms: anorexia, thirst, polyuria, loss of appetite, dizziness, fainting states, weakness, nausea, vomiting, hypercalciuria, hypercalcemia, hypercreatinemia. With long-term use of excessive doses, calcification of blood vessels and tissues. Treatment: introduction into the body large quantity fluids, the use of loop diuretics (for example, Furosemide), glucocorticosteroids, calcitonin, bisphosphonates.
If you notice signs of overdose, seek help from a doctor. In case of development clinical symptoms overdose, the concentration of calcium and creatinine in the blood should be determined. When increased concentration calcium or creatinine in the blood serum, the dose of the drug should be reduced or treatment should be temporarily stopped.
In case of hypercalciuria exceeding 7.5 mmol/day (300 mg/day), it is necessary to reduce the dose or stop taking it. Interaction with other drugs
Chewable tablets 20, 50 or 100 tablets in a polyethylene bottle high density, sealed with a screw cap, under which there is a ring for tearing off the sealing gasket, ensuring control of the first opening. Part of the label is attached to the bottle with a special adhesive tape, which allows the label to be lifted. Instructions for use in the form of a folding sheet are placed under the movable part of the label. Best before date
3 years
Do not use after expiration date. Storage conditions
Store the bottle tightly closed at a temperature not exceeding 25° C in a dry place. Keep out of the reach of children! Conditions for dispensing from pharmacies
Without a doctor's prescription Manufacturer
Nycomed Pharma AS, Norway. Manufacturer's address
Nycomed Pharma AS
Drammensveien 852, N-1385 Asker, Norway
Nycomed Pharma AS
Drammensveien 852 N-1385 Asker, Norway Representative office address in Russia/CIS:
119049 Moscow, st. Shabolovka, 10
In this article you can find instructions for use medicinal product Calcium D3 Nycomed. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Calcium D3 Nycomed in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Calcium D3 Nycomed if available structural analogues. Use for the treatment of calcium deficiency and prevention of osteoporosis in adults, children, as well as during pregnancy and lactation.
Calcium D3 Nycomed - combination drug, regulating the exchange of calcium and phosphorus in the body (in bones, teeth, nails, hair, muscles).
Reduces resorption (resorption) and increases bone density, replenishing the lack of calcium and vitamin D3 in the body, necessary for the mineralization of teeth.
Calcium is involved in the regulation of nerve conduction, muscle contractions and is a component of the blood coagulation system.
Vitamin D3 (colecalciferol) increases calcium absorption in the intestines.
The use of calcium and vitamin D3 prevents an increase in the production of parathyroid hormone, which is a stimulator of increased bone resorption (leaching of calcium from the bones).
Pharmacokinetics
Vitamin D3 is absorbed in the small intestine.
Calcium is absorbed in ionized form in the proximal region small intestine via an active vitamin D-dependent transport mechanism.
Compound
Colecalciferol (vitamin D3) + calcium carbonate + excipients.
Indications
- prevention and treatment of calcium and/or vitamin D3 deficiency (vitaminosis, hypovitaminosis);
- prevention and complex therapy of osteoporosis (including menopausal, senile, steroid, idiopathic).
Release forms
Chewable tablets.
Pills Chewable Calcium D3 Nycomed forte (increased dose of vitamin D3).
Instructions for use and dosage regimen
For the treatment of osteoporosis, adults are prescribed 1 tablet 2-3 times a day, for the prevention of osteoporosis - 1 tablet 2 times a day.
For calcium and vitamin D deficiency, adults and children over 12 years of age are prescribed 1 tablet 2 per day, children aged 5 to 12 years - 1-2 tablets per day, children aged 3 to 5 years are prescribed the dosage regimen individually.
The tablet can be chewed or dissolved and taken with food.
Side effect
- constipation;
- diarrhea;
- flatulence;
- nausea;
- stomach ache;
- hypercalcemia;
- hypercalciuria;
- allergic reactions.
Contraindications
- hypercalcemia;
- hypercalciuria;
- nephrolithiasis;
- hypervitaminosis D;
- severe renal failure;
- active form of tuberculosis;
- sarcoidosis;
- children under 3 years of age;
- hypersensitivity to the components of the drug.
Use during pregnancy and breastfeeding
Caution should be exercised when prescribing the drug during pregnancy and lactation.
During pregnancy daily dose The drug should not exceed 1500 mg of calcium and 600 IU of vitamin D3. Hypercalcemia, which develops against the background of an overdose during pregnancy, can cause defects in the mental and physical development of the child.
Vitamin D and its metabolites can be released from breast milk, therefore it is necessary to consider additional intake of calcium and vitamin D from other sources in the mother and child.
Use in children
Contraindicated in children under 3 years of age.
special instructions
Calcium D3 Nycomed tablets contain aspartame, which is transformed into phenylalanine in the body, so the drug should not be taken if you have phenylketonuria.
When using drug Calcium-D 3 Nycomed in patients receiving cardiac glycosides and/or diuretics, it is necessary to monitor the concentration of calcium and creatinine in the blood serum.
In case of increased concentration of calcium or creatinine in the blood serum, as well as in case of hypercalciuria exceeding 7.5 mmol per day (300 mg per day), the dose of the drug should be reduced or treatment should be temporarily stopped.
To avoid overdose, additional vitamin D3 intake from other sources must be taken into account.
Eating foods containing oxalates (sorrel, spinach) and phytin (cereals) reduces the absorption of calcium, so you should not take Calcium-D3 Nycomed within 2 hours after taking sorrel, spinach, cereals.
Calcium-D3 Nycomed should be used with caution in immobilized patients with osteoporosis due to the risk of developing hypercalcemia.
Drug interactions
When used simultaneously with phenytoin or barbiturates, a decrease in the activity of vitamin D3 is possible.
Calcium preparations can potentiate the therapeutic and toxic effects of cardiac glycosides, therefore, with the simultaneous use of the drug Calcium D3 Nycomed and cardiac glycosides, monitoring of the ECG and the clinical condition of the patient is necessary.
Calcium and vitamin D3 preparations can increase the absorption of tetracyclines from the gastrointestinal tract, therefore the interval between doses of the drug Calcium-D3 Nycomed and antibiotics of the tetracycline group should be at least 3 hours.
When used simultaneously with bisphosphonates or sodium fluoride, their absorption may be reduced, so it is recommended to take Calcium-D3 Nycomed no earlier than 2 hours after these medications.
GCS reduce calcium absorption, so patients receiving GCS may require an increase in the dose of Calcium-D3 Nycomed.
When used simultaneously with cholestyramine or laxatives based on mineral or vegetable oil, the absorption of vitamin D3 may be reduced.
When used simultaneously with thiazide diuretics, the risk of developing hypercalcemia increases due to increased tubular reabsorption of calcium. Furosemide and other “loop” diuretics, on the contrary, increase calcium excretion by the kidneys.
Analogues of the drug Calcium D3 Nycomed
Structural analogues of the active substance:
- Ideos;
- Calcium + Vitamin D3 Vitrum;
- Calcium D3 Classic;
- Calcium-D3-MIC;
- Complivit calcium D3;
- Complivit Calcium D3 for babies;
- Complivit calcium D3 forte;
- Natekal D3;
- Revital Calcium D3.
If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.
The effectiveness of treatment with medications can be significantly enhanced quite simple methods. One of the most accessible is to understand what time is best to take the medicine and try to adhere to this particular regimen. For example, to restore bones great importance has when to take calcium in the morning or evening. And about this - right now.
This element plays a vital role not only for the health of bones.
Along with this main task, it performs the following functions:
- Provides the process of muscle contraction and thus participates in the heartbeat (the myocardium is the main muscle of the heart that pumps blood through the vessels).
- Provides blood clotting processes, as it enhances the effect of vitamin K, which is involved in these reactions.
- Provides a mechanism for the selective permeability of substances through cell membranes (barriers): some substances pass through it, others do not.
- This element takes part in the process of formation and transmission of impulses through cells nervous system(neurons).
- Participates in metabolic and hormonal processes by activating some vital chemical reactions in organism.
First of all, medications containing this element should be used by those people who are at risk:
- suffering from osteochondrosis, arthritis or having prerequisites for their development (for example, hereditary);
- have suffered various fractures and other bone injuries;
- predisposed to colon cancer;
- by gender - women are more susceptible to a lack of this element due to the hormonal characteristics of the body;
- leading an unhealthy lifestyle in terms of unbalanced diet: excess carbonated drinks, sweets, flour products, coffee, alcohol and fatty foods, as well as foods with excess salt (chips, pickles for the winter, etc.);
- based on age - people over 60 need special care for their bones due to the gradual weakening of bone tissue and salt deposits.
On the other hand, even if a person does not fall into any of these categories, he may, on the advice of a doctor, decide to take appropriate medications, especially if he exhibits some of the following symptoms:
- Unexplained anxiety, irritability, insomnia.
- Frequent numbness in the arms and legs, frequent seizures, involuntary muscle contractions.
- Pain in joints, bones, painful sensation in the gums.
- Brittle nails.
- Women have unusually heavy menstrual flow.
- Children experience severe growth retardation and often have a desire to eat chalk.
NOTE
None of the listed signs is an absolutely accurate signal to start taking medication. Before deciding on therapy, you should definitely consult a doctor for advice.
The list of foods rich in calcium (in descending order) is as follows:
- Group of dairy products - cheeses (the record holder for content is Parmesan), cottage cheese, sour cream, kefir, yogurt.
PLEASE NOTE – Contrary to popular belief, milk is not the most best source calcium. The fact is that, along with this element, it contains lactose, which belongs to simple carbohydrates, in excess is harmful to bones. A much more suitable product is cheese, which does not contain lactose at all.
- Greens and some vegetables: all types of cabbage, parsley, spinach, dill.
- Almost all nuts, especially almonds and Brazil nuts.
- Sesame and poppy seeds.
- Whole grain flour (premium flour contains no calcium).
- Soy and products based on it.
- Molasses is a great option for those with a sweet tooth. If you replace sugar with molasses, the benefit for the body is double: it will be saturated with calcium, and on the other hand, it will avoid harmful effects excess sugar.
NOTE
You should not focus on just one product - your diet should be varied. In addition, the constant consumption of monotonous food has a bad effect on the condition of the gastrointestinal tract.
Oddly enough, in the medical community there is no unambiguous and clear answer to the question of when it is better to take calcium-containing drugs (for example, calcium d3 nycomed). Therefore, you should not expect clear recommendations on this matter.
However, there are several simple rules, compliance with which is guaranteed to increase the effect of therapy due to more complete absorption of the components:
- Since there are equally opinions that you can take calcium during the day and you can drink it in the evening, then the most correct option– split the dose into at least 2 parts and take it like most other drugs: morning and evening. Or break it into three parts and take it morning, lunch and evening. At the same time, it has been proven that frequent intake in small portions is much more effective than a single large portion - it is not absorbed in full.
- Fundamentally important point, where many people make a mistake, as a result of which taking calcium-containing medications turns out to be virtually pointless: they use these medications only in conjunction with those substances that promote its absorption bone tissue. This is vitamin D, food and preparations containing phosphorus and magnesium - these elements themselves are beneficial and enhance the effect of calcium.
PLEASE NOTE – Vitamin D is found in beef liver, sour cream, egg yolk, fish oil, herring, and there is especially a lot of it in the liver of any kind sea fish. All nuts, sunflower seeds, beans, green apples, green bell pepper. Phosphorus is found in dairy products, meat and poultry, eggs, fish, walnuts, oatmeal.
- Along with the fact that it is important to know when it is best to drink calcium, its combination with food plays an equally significant role. It is important to take medications only after a light, low-fat meal. And do not take them in combination with certain organic acids (oxalic and phytic) - accordingly, do not eat sorrel, spinach, or beets at the same time.
- It is important dosage form drug. If you can purchase the medicine in liquid or powder form, this is better than tablets.
- However, among tablets there are also different variants– from traditional to chewy and fizzy. The last type is the best, it is absorbed most fully and quickly.
- In the instructions for the drug, it is necessary to specify in what form calcium is contained, i.e. which active substance is the basis of this medicine. Calcium carbonate is well absorbed during or immediately after meals. And gluconate, lactate and calcium citrate (organic forms) are absorbed regardless of food and time of day.
- Finally, like most other medications, medications with calcium are always taken with an excess amount of liquid - 1-2 glasses.
Thus, the effectiveness of taking calcium-containing medications primarily depends not on what time of day is best to take them, but on the following factors:
- combination with certain foods;
- combination with drugs that promote the perception of calcium and its most complete absorption by bone tissue;
- chemical (medicinal form of the drug).
Therefore, the question at what time of day calcium is best absorbed can be largely replaced by the question: in combination with what drugs and food this element brings more benefits.
NOTE
Before taking calcium, you should definitely consult your doctor to avoid possible side effects related to features specific organism. In any case, long-term calcium intake over 6-12 months (or several years) can lead to the formation of kidney stones.
Thus, calcium is one of the vital important elements, without which the body cannot do. And it is important to take medications containing it only on the basis of the above rules. Otherwise, the effect of therapy will be virtually zero.
Calcium-D3 Nycomed is a mineral supplement that regulates the metabolism of calcium and phosphorus.
Release form and composition
Dosage form of the drug – chewable tablets:
- Orange - in high-density polyethylene bottles of 20, 50 or 100 pcs., 1 bottle in a cardboard box;
- Mints - in high-density polyethylene bottles of 30 or 100 pcs., 1 bottle per package.
Active ingredients:
- Calcium carbonate – 1250 mg (corresponding to 500 mg of elemental calcium);
- Colecalciferol (vitamin D3) – 5 mcg (200 IU).
Excipients of tablets:
- Orange - povidone, sorbitol, isomalt, magnesium stearate, aspartame, mono- and diglycerides of fatty acids, orange oil;
- Mints - sorbitol, povidone, magnesium stearate, aspartame, mint flavor.
Indications for use
- Treatment of deficiency and prevention of calcium and/or vitamin D3 deficiency;
- Prevention and treatment (includes complex therapy) osteoporosis and its complications.
Contraindications
- Hypercalciuria;
- Hypercalcemia;
- Severe renal failure;
- Nephrolithiasis;
- Hypervitaminosis D;
- Active form of tuberculosis;
- Sarcoidosis;
- Children under 3 years of age;
- Phenylketonuria;
- Hereditary fructose intolerance, glucose-galactose malabsorption and sucrase-isomaltase deficiency;
- Hypersensitivity to the components of the drug, soy or peanuts.
Patients with renal failure, pregnant and breastfeeding women.
Directions for use and dosage
The drug should be taken with food, the tablets must be dissolved or chewed until completely dissolved.
- To compensate for the lack of calcium and vitamin D: children over 12 years old and adults - 1 tablet twice a day, children 5-12 years old - 1-2 tablets per day, children 3-5 years old - as prescribed by a doctor;
- For the prevention of osteoporosis: adults – 1 tablet twice a day;
- As part of complex therapy for osteoporosis: adults – 1 table. 2-3 times a day.
As a means of replenishing calcium and vitamin D3 deficiency, the drug is taken in courses of at least 4-6 weeks, the number of courses during the year is determined individually.
As a drug intended for the prevention and treatment of osteoporosis, duration of use mineral supplement determined by the doctor individually for each patient.
Side effects
In general, Calcium-D3 Nycomed is well tolerated; in rare cases, the following side effects are noted:
- Digestive system: abdominal pain, flatulence, constipation or diarrhea, nausea, dyspepsia;
- Metabolism: hypercalciuria and hypercalcemia;
- Skin and subcutaneous tissue: rash, itching, urticaria.
An overdose of calcium is fraught with the development of hypercalcemia, its symptoms: thirst, muscle weakness, abdominal pain, constipation, nausea, vomiting, polyuria, increased fatigue, anorexia, bone pain, urolithiasis disease, nephrocalcinosis, mental disorders. IN severe cases cardiac arrhythmias are added. With long-term use in excessive doses (more than 2500 mg of calcium), kidney damage and soft tissue calcification are possible. If any of the described symptoms appear, you should stop taking Calcium-D3 Nycomed and consult a doctor. First aid for overdose involves gastric lavage, then prescribe loop diuretic(eg, furosemide), glucocorticosteroid, calcitonin and bisphosphonates, and replacement of lost fluid is also indicated. It is necessary to monitor diuresis, renal function and electrolyte levels in the blood; in severe cases, ECG monitoring and measurement of central venous pressure are required.
Hypercalcemia that develops as a result of overdose during pregnancy can have an adverse effect on the fetus.
special instructions
To prevent an overdose, it is necessary to take into account the supply of vitamin D3 and calcium from other sources, and when taking a mineral supplement during lactation, not only for the mother taking Calcium-D3 Nycomed, but also for the child.
At long-term treatment it is necessary to monitor the content of creatinine and calcium in the blood, especially in elderly people who are taking diuretics and cardiac glycosides, and in patients at risk of developing kidney stones. If signs of hypercalcemia or renal dysfunction appear, the dose of Calcium-D3 Nycomed should be reduced or completely stopped.
When prescribing the drug to patients with renal failure, the risk of developing soft tissue calcification should be taken into account. During the treatment process, it is necessary to control the content of phosphates and calcium in the blood serum.
The drug can be used during pregnancy. However, it should be borne in mind that the daily dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3.
The supplement should be used with caution in immobilized patients with osteoporosis, because they are at high risk of developing hypercalcemia.
Calcium-D3 Nycomed does not have a negative effect on the speed of reactions and the ability to concentrate.
It is important to know that foods containing oxalates (spinach, sorrel, rhubarb) and phytin (cereals) reduce calcium absorption, so Calcium-D3 Nycomed should not be taken within 2 hours after eating them.
Drug interactions
It is not recommended to take the drug simultaneously with tetracycline antibiotics and quinolone, since their absorption is reduced. If such a combination is still necessary, it is recommended to take these medications 2 hours before or 4-6 hours after taking Calcium-D3Nycomed. The patient must be under close medical supervision throughout the entire treatment period.
Hypercalcemia that develops as a result of taking a mineral supplement can potentiate the toxic effects of cardiac glycosides. Monitoring serum calcium concentration and ECG monitoring is necessary.
Calcium absorption is reduced by glucocorticosteroids, so an increase in the dose of the supplement may be required.
Calcium reduces absorption and reduces the effectiveness of levothyroxine, so the interval between doses should be at least 4 hours. Bisphosphonates, if necessary, are recommended to be taken no later than 1 hour before taking Calcium-D3Nycomed.
The risk of developing hypercalcemia increases with simultaneous use of thiazide diuretics. In this case, it is necessary to regularly monitor the concentration of calcium in the blood serum.
Terms and conditions of storage
Store in a tightly closed bottle in a dry place, out of reach of children, at temperatures up to 25 ºС.
Shelf life – 3 years.
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