Interferon human leukocyte dry - a group of proteins synthesized by leukocytes donated blood in response to the influence of an interferon inducer virus. Antibodies to the HIV-1 virus, HIV-2 virus, hepatitis C virus and hepatitis B virus surface antigen are absent.
Active ingredient: interferon alpha
Activity: not less than 1000 ME per ampoule.
Auxiliary components:
Sodium chloride - 0.09 mg;
Sodium dihydrogen phosphate dihydrate - 0.06 mg;
Sodium hydrogen phosphate dodecahydrate - 0.003 mg;
Sucrose - 0.03 mg.
Description:A porous amorphous mass or powder of white or light yellow to bright red color. Hygroscopic.
The reconstituted drug is a clear liquid from light yellow to bright red.
Pharmacotherapeutic group: MIBP - cytokine ATX:L.03.A.B.01 Interferon alpha
Pharmacodynamics:Interferon alpha has the following effects:
Antiviral (flu, herpes, adeno viral infections and etc.);
Antibacterial (bacteriostatic) against mixed infections;
Immunomodulatory (normalizes immune status);
Immunostimulating (strengthens the immune response);
Anti-inflammatory.
Interferon alpha from normal human leukocytes has an indirect antiviral effect, which consists of creating protective mechanisms in cells not infected with the virus: changing the properties of cell membranes that prevent the virus from penetrating into the cell; initiation of the synthesis of a number of Specific enzymes that prevent the replication of viral RNA and the synthesis of viral proteins.
Pharmacokinetics:The main properties of interferon alpha are used with therapeutic purpose. inhibits the replication and transcription of viruses and chlamydia. Has an antiviral effect, inducing a state of resistance to viral infections in cells and modulating the response immune system, aimed at neutralizing viruses or destroying cells infected by them. The mechanism of antiviral action is to create protective mechanisms in cells not infected with the virus. By binding to specific receptors on the cell surface, it changes the properties of the cell membrane, prevents adhesion and penetration of the virus into the cell, stimulates specific enzymes, affects RNA and inhibits the synthesis of viral proteins. Suppresses viral replication in an infected cell. The listed properties of interferon alpha allow it to effectively participate in the processes of pathogen elimination, prevention of infection and possible complications. Thanks to the immunomodulatory activity of interferon alpha, normalization occurs immune status. The immunomodulatory effect is due to stimulation of the activity of macrophages (phagocytic activity) and natural killer cells (NK cells). Stimulates the process of antigen presentation by macrophages immunocompetent cells. Under the influence of interferon alpha in the body, the activity of T-helpers, cytotoxic T-lymphocytes, the expression of MHC type I and II antigens, as well as the intensity of differentiation of B-lymphocytes increases. Activation of leukocytes ensures their active participation in the elimination of primary pathological foci and ensures the restoration of production secretory immunoglobulin A.
Indications: Prevention and treatment of influenza and other acute respiratory viral infections. Contraindications:Use with caution in persons with hypersensitivity to antibiotics and hypersensitivity to preparations of protein origin, including chicken meat and chicken eggs. Carefully:Persons with allergic diseases in the anamnesis.
The drug can be used by children and adults with chronic diseases.
Pregnancy and lactation:During pregnancy and lactation, Interferon is prescribed only if the expected effect for the mother exceeds the risk for the fetus. Directions for use and dosage:Open the ampoule with the drug immediately before using it and add sterile distilled or cooled boiled water in a volume of 2.0 ml, that is, up to the color line marked on the ampoule. Dissolution time should not exceed 3 minutes. The dissolved drug should be clear liquid, having shades from light yellow to bright red.
The drug solution can be stored at temperatures from 2 °C to 8 °C for no more than one day.
For prevention and treatment, the same dosage regimen is used for children and adults. There is no age limit for children.
Use for prevention:
For the purpose of prevention, administration of the drug should begin when there is an immediate threat of infection and continue as long as the risk of infection remains. To prevent influenza and other acute respiratory viral infections, use the dissolved drug intranasally.
Spraying the drug solution can be done using sprayers of any system. 0.25 ml of solution should be administered into each nasal passage 2 times a day, with an interval of at least 6 hours.
When instilling the drug solution, administer 5 drops (0.25 ml) into each nasal passage 2 times a day with an interval of at least 6 hours.
Use in treatment:
For treatment purposes, the drug should be used on early stage disease when the first clinical symptoms appear.
When treating the drug, use it inhalation and intranasally. Most in an efficient way is inhalation. To carry it out, inhalers equipped with electric heating or another system are recommended. For one administration, use the contents of 3 ampoules of the drug, which are dissolved in 10 ml of sterile distilled or boiled water. Heat the solution to a temperature not higher than 37 °C. The drug is administered by inhalation 2 times a day with an interval of at least 6 hours.
Spraying the drug solution can be done using sprayers of any system. 0.25 ml of solution should be injected into each nasal passage after 1-2 hours, at least 5 times a day for 2-3 days.
When instilling the drug solution, administer 5 drops (0.25 ml) into each nasal passage after 1-2 hours, at least 5 times a day for 2-3 days.
Precautions for use:
Administration by injection is strictly prohibited.
The drug is unsuitable for use if:
- the seal of the packaging is broken;
- markings are missing or difficult to read;
- expiration date has expired.
Side effects:There were no registered side effects. With long-term use, no sensitization was detected. Allergic reactions (urticaria, polymorphic rash) may develop in people who have hypersensitivity to antibiotics and hypersensitivity to drugs of protein origin, including chicken meat and chicken eggs. Overdose: No cases of overdose have been identified. Interaction:In tissue culture experiments carried out in the antibiotic laboratory, it was found that when joint use methyluracil with dry human leukocyte interferon, a pronounced synergistic effect is observed. A pronounced synergistic effect is observed when human leukocyte interferon is combined with lysozyme.
Instructions for medical use
Human leukocyte interferon
Tradename
Human leukocyte interferon
International nonproprietary name
Interferon alpha
Dosage form
Lyophilisate for the preparation of solution for intranasal administration 1000 IU
Compound
One ampoule contains
active substance - human leukocyte a-type interferon with antiviral activity of at least 1000 IU
Description
Porous amorphous mass or powder, white or light yellow to pink. Hygroscopic.
Pharmacotherapeutic group
Immunomodulators. Immunostimulants. Interferons. Interferon alpha is natural.
ATX code L03AB01
Pharmacological properties Pharmacokinetics
Pharmacokinetic studies have not been conducted.
Pharmacodynamics
Human leukocyte interferon (Interferon alpha), a lyophilisate for the preparation of a solution for intranasal administration, is a group of proteins synthesized by leukocytes of donor blood in response to the influence of an interferon-inducing virus.
Interferon alpha has the ability to stimulate the phagocytic activity of macrophages, as well as the cytotoxic activity of T cells and “natural killer” cells, has an indirect antiviral effect, inducing a state of resistance to viral infections in cells and modulating the response of the immune system aimed at neutralizing viruses or destroying those infected with them cells.
The drug does not contain antibodies to human immunodeficiency viruses (HIV-1, HIV-2), hepatitis C virus and hepatitis B virus surface antigen (HBsAg).
Indications for use
Prevention and treatment of influenza and other acute respiratory viral infections
Directions for use and doses
For the purpose of prevention
Administration of the drug should begin when there is an immediate threat of infection and continue as long as the risk of infection remains. The drug is administered to adults and children from birth in the same dose by spraying or instilling an aqueous solution into the nose.
The ampoule with the drug is opened immediately before use. Sterile distilled or cooled boiled water is added to the ampoule to the level corresponding to 2 ml, carefully shaken until the contents are completely dissolved. The dissolved drug is a clear or slightly opalescent liquid, colorless or light yellow to pink. The dissolved drug can be stored for 24 hours at a temperature of 2 °C to 8 °C.
Spraying can be carried out using sprayers of any system in accordance with the instructions attached to them. 0.25 ml of solution should be administered into each nasal passage twice a day with an interval of at least 6 hours. When instilled, the drug is administered 5 drops into each nasal passage 2 times a day with an interval of at least 6 hours.
The drug is used in the same dose for adults and children from birth by spraying or instillation into the nose.
When sprayed or instilled, the drug is dissolved in 2 ml of water and 0.25 ml (5 drops) is administered into each nasal passage after 1-2 hours at least 5 times a day for 2-3 days.
Side effects
During the use of the drug side effects not registered.
Contraindications
Hypersensitivity to interferon drugs
Drug interactions
Can be used simultaneously with other antiviral drugs local application and congestants.
special instructions
Administration of the drug by injection is strictly prohibited!
Use with caution for persons with allergic diseases.
At allergic reactions immediate type carry out symptomatic therapy.
Use in pediatrics
For children from the neonatal period (from birth), the drug is used by spraying or instillation.
Pregnancy and lactation
Human leukocyte interferon is a unique product with pronounced immunomodulatory and immunostimulating capabilities. This medicine is capable of reducing the growth of tumors, which is achieved due to the presence of interferon alpha in it.
The latter refers to a group of proteins produced by white blood cells in human blood. They help our body fight a large number of diseases of viral, fungal, infectious and other nature.
Indications for use
What helps to cure leukocyte interferon? When used correctly and in a timely manner, it speeds up recovery in the case of the following ailments:
- respiratory system infections;
- bacterial infections;
- immunodeficiency;
- viruses;
- benign and malignant neoplasms;
- kidney and liver diseases;
- infections of fungal origin;
- pathologies of the mucous membranes and eyes.
Leukocyte interferon is used to prevent these health problems and strengthen the immune system in general.
The drug is included in complex therapy many pathologies, and its dosage is prescribed only on an individual basis.
Release forms
Interferon is available in ampoules, in the form of suppositories, ointments and in the form of a dry powder - a lyophilized substance. The latter needs to be diluted with saline solution, while the substance in ampoules is already ready for use.
pharmachologic effect
Human protein, which is interferon, is able to exert its healing effects immediately after entering the body. It inhibits the activity of pathological microorganisms and increases the protective abilities of the body as a whole.
Because of the latter property, a person who has consumed the powder may experience a slight rise in temperature, which is considered an adequate response to an increase in the concentration of interferon in the blood. As you already know, the vast majority of bacteria and viruses die at 37 degrees.
Interferon for children
- Interferon ampoules
Inhalations based on human protein are quite effective. For them, you need to dissolve the contents of three ampoules in 10 ml of boiled water and perform irrigation procedures for the oral (nasal) cavity twice a day.
- Interferon powder
Having purchased the dry form of the drug, the powder in a glass pharmaceutical container must be diluted with two milliliters of warm boiled water. The interval between instillations is 6 hours, while the general course lasts until the threat of infection with the virus passes.
If human interferon is used for intensive healing, it must be diluted in a similar way (applies to the powder form), but drip after a couple of hours, again, five drops into each nostril of the child.
- Interferon ointment
Interferon in the form of an ointment is a convenient everyday remedy against viruses. It can be used to treat not only the nostrils, but also the tonsils.
- Interferon suppositories
As for suppositories, they are more often recommended for use in newborns or when therapeutic effect needs to be achieved as quickly as possible. Once in the rectum, human interferon instantly penetrates the blood and begins its healing effect. It is customary to administer the drug rectally every 12 hours, but not more than five days in a row.
Interferon for adults
- Eye pathologies: the powder is diluted with one milliliter of boiled water and buried under the lower eyelid. The procedure must be repeated 10 times a day, while the general course can take two days or a couple of weeks;
- Viral, bacterial and colds respiratory tract: the powder is diluted in 2 ml of warm boiled water and on the first day of illness, 1-3 drops are administered into each nostril every 2 hours. The interferon is then divided into 5 doses maximum;
- Immunodeficiency, as well as conditions with benign and malignant neoplasms is adjusted according to the following scheme: Interferon powder is diluted with saline and injected intramuscularly. If you need to do intravenous injection, sodium chloride is used for dilution.
Contraindications for use
The instructions for use of the protein categorically do not recommend including the drug in treatment regimens if the following deviations are present:
- Personal intolerance to a substance pure form;
- Increased sensitivity to chicken protein;
- Antibiotic intolerance;
- Complex organic pathologies;
- CNS dysfunctions;
- Malfunctions of the liver, thyroid gland or kidneys;
- Chronic form of hepatitis;
- Cirrhosis of the liver;
- Taking sedative medications or immunosuppressants;
- Use of strong sleeping pills or opioid analgesics.
Interferon and alcohol
Dry powder is not suitable for use with alcohol.
Alcohol greatly detracts from the positive properties that drugs based on it bring with them, and provokes a large number of side effects in the form of:
- vomiting and nausea;
- depression;
- headaches and dizziness;
- rapid heartbeat;
- appetite suppressants;
- suicidal states;
- changes in liver function, etc.
The most interesting thing is that the effect of synthetically produced protein on human body has not yet been fully studied, and doctors are finding more and more new indications for its use. This leads to a logical conclusion: the consequences of taking the drug in tablets or intramuscularly, supplemented by drinking alcohol, can be completely unpredictable, and it’s good if it all ends in allergies or one-time vomiting.
Viral diseases occur to the average person several times a year. You can fight them in different ways. But the quality of treatment and the speed of recovery depends on the effectiveness of the medications used. One of the best on this moment drugs for viral diseases is Interferon.
It should be noted that human leukocyte Interferon is an excellent immunomodulatory, antiviral and antitumor drug. This remedy helps the body's cells organize additional protection against the virus.
IMPORTANT: Interferons are proteins that the body produces when a virus enters it. The drug in question helps to activate the body’s process of producing protective proteins.
In 1957, virologists A. Isaac and D. Lindeman discovered an amazing defense mechanism, which turns on in the cells of the body at the time of infection of one of them. This mechanism is “prescribed” at the genetic level. When one of the cells becomes infected with a virus, it produces special protein molecules (interferons). These molecules enter neighboring cells and make them immune to the virus.
Human leukocyte interferon is a protective protein that, when it enters the body, helps the immune system and fights painful viruses.
Release form
The product is available in the form:
- Candles for rectal use 40,000 ME
- Lyophilisate for preparing a solution for nasal instillation 1000 IU
- Liquid solution for inhalation and topical use 1000 IU/ml
Indications for use
Interferon is indicated for the treatment of influenza and ARVI. He is able to help with tick-borne encephalitis and hepatitis C and B. Contains complex treatment this remedy is prescribed for leukemia, malignant and benign neoplasms.
Drops of this remedy are used to treat viral eye infections: keratitis, keratouveitis and conjunctivitis.
Rectal suppositories of this drug are used for secondary immunodeficiency conditions.
Interferon for children
- Drops of this medicine are used for the treatment and prevention of infectious viral diseases in children. This drug can be used from birth
- Prepare a solution for instillation into the nose by adding 2 ml of chilled water to an ampoule with this product. The prepared solution should be instilled into each nostril and then massaged into the wings of the nose. This is done to ensure that the solution is distributed correctly.
- To prevent ARVI, the solution for children should be instilled 5 drops into each nostril 2 times a day. At least 6 hours should pass between such instillations. For prevention this medicinal product should be used as long as the risk of infection remains
- If a child has signs of ARVI, you need to start taking Interferon as soon as possible. For 2-3 days you need to instill a solution of 5 drops every 1-2 hours
Interferon dosage
- This drug in injection solution is used subcutaneously, intramuscularly and intravenously. The dosage is determined by the attending physician and depends on the age and nature of the disease.
- "Interferon" in the form of a powder or ready-made solution can be used as a liquid for inhalation
- This remedy can be used for the treatment and prevention of acute respiratory viral infections. To do this, I instill 5 drops of the solution into each nostril. For prophylaxis, 6 hours should pass between instillations. During treatment, this should be done every 1-2 hours
- For viral conjunctivitis, the solution is instilled 1-2 drops into each eye 6-8 times a day
- During treatment acute hepatitis B use this remedy in the form of suppositories. The dosage should be selected by the doctor based on the individual characteristics of the body. The course of treatment should not exceed 14 days
Interferon in ampoules
- Ampoules with this product are the most popular form of Interferon. They are used to prevent viral diseases. To do this, the contents of the ampoule are poured into water to the 2 ml mark. Apply 5 drops of this solution to your nose twice a day.
- To treat viral diseases, you need to increase the dosage of this drug. Most intensive treatment necessary in the first 2-3 days of illness
- You can use Interferon for inhalation. To do this, you need to dilute the contents of the ampoule in 10 ml of warm water.
Interferon contraindications
Do not use the drug for:
- Severe heart disease
- Impaired kidney and liver function
- At chronic hepatitis and liver cirrhosis
- Autoimmune hepatitis
- Epilepsy
- Violations of the central nervous system
- Hypersensitivity to interferon alfa
- Diseases thyroid gland
During pregnancy, this drug is prescribed with great caution. It can be used only if the risk of threat to the fetus is less than the benefit of this remedy for the woman. Interferon can be used only from the twenty-eighth week of pregnancy.
Elderly people can be prescribed this drug. But it must be used extremely carefully. It is necessary to establish special monitoring of such patients.
Interferon or Viferon?
Both drugs contain the same active ingredient. But, unlike Interferon, it contains vitamins and other useful compounds. In addition, “Viferon” in the form of suppositories is easier and more convenient to use to treat a child. It is more convenient to store Viferon. Interferon solution cannot be stored for more than 12 hours.
Analogues
"Alfaferon"
"Gripferon"— immunomodulatory drug (drops and spray) with antiviral effect based on interferon alpha. Used for the prevention and treatment of viral infections.
- Dosage: depends on the disease. Course: prescribed by the attending physician
"Wellferon"- solution for injection based on active substance interferon alpha. Used to combat viral infections.
- Dosage: depends on the disease. Course: prescribed by the attending physician
"Inferon"- a medicine made on the basis of interferon alpha that has an antiviral effect. Used for the prevention and treatment of acute respiratory viral infections, influenza and other diseases.
- Dosage: depends on the type of disease. Course: prescribed by the attending physician
"Lokferon"- a medicine made on the basis of interferon alpha with antiviral effect. Available in the form of a lyophilisate for preparing a solution.
- Dosage: depends on the severity of the disease and indications. Course: prescribed by the attending physician
Oleg. Not a bad remedy. I noticed that if you start using it in time at the first signs of the disease, you can quickly get back on your feet. The last two times I recovered in 2-3 days. I advise everyone.
Ilona. Immunomodulators are certainly good, but I would not recommend using them often. Our body is “lazy” and if it sees that someone is working for it, it immediately starts slacking. This also applies to the immune system. Therefore, you need to weigh the pros and cons when taking this medicine. Yes, during a flu epidemic it is still better to use Interferon. But, in all other cases, the body must fight on its own.
Video: What are the differences between immunostimulants?
Effective therapeutic and prophylactic– interferon. The spectrum of its action is very wide, production is established both abroad and in our country, the price range is accessible to everyone.
Indications for use
The product has primarily antiviral and immunoforming properties, and also has an antiproliferative (stopping tissue growth) effect.
Application for various diseases has long been tested and the results have been recorded, the drug is approved in Russia for the treatment of the following diseases and conditions:
- respiratory viral infections, incl. and pneumonia and their prevention;
- hepatitis B, C, D(delta);
- herpes and herpes zoster;
- some malignant diseases;
- papillomas;
- certain fungal diseases;
- conditions after chemotherapy and radiation exposure;
- decreased immunity of various origins.
Directions for use and doses
Human leukocyte interferon is available in several forms and is used in various ways.
- Suppositories are used rectally once a day to prevent ARVI in children for a month. For treatment respiratory diseases used 2 times a day, in courses of 5-10 days, dose of 250,000 IU of active substance. In this case, it is necessary to observe the administration interval - no more than 12 hours. In doses of 500,000 IU, they are also used in adults 2 times a day.
- Suppositories are used vaginally for viral diseases genitourinary area twice a day, in a dose of up to 1,000,000 IU, determined by a doctor, for 10 days - the substance has local impact and penetrates the bloodstream. When alternating with other medications, use 1 time per day. The doctor may also recommend a maintenance dose once every 1 to 3 days for 10 to 30 days.
- Interferon is available for injection and must be administered subcutaneously, intradermally, intramuscularly or intravenously. It is sold strictly according to prescription. Be careful, human leukocyte interferon,intended for nasal irrigation, it is strictly prohibited to administer by injection.
- Dry powder is intended for dilution with distilled or boiled water and is used for irrigation of mucous membranes. After opening, the ampoule or bottle is stored for a maximum of 24 hours. Place 5 drops in the nostril twice a day.
- Nasal and eye drops- ready-to-use solutions used topically for direct application or as inhalation through a nebulizer.
- Interferon-based ointments are applied to areas of infection on the skin, for example, for herpes rashes, at least 2 times a day.
The exact dosage of the drug is prescribed exclusively by the doctor, who, if necessary, adjusts the method and frequency of use.
Self-prescription and use of the drug is unacceptable!
Contraindications
Interferon affects the functioning of the entire body, so in some cases unwanted side effects may occur. To prevent them, you should strictly follow your doctor’s instructions and not exceed the dose.
Contraindications for use are:
- decreased kidney function;
- cirrhosis of the liver;
- serious illnesses hearts;
- epilepsy;
- depression and psychosis;
- changes in thyroid function that are resistant to therapy;
- individual hypersensitivity.
Special Terms of Use
Interferon is not prescribed to pregnant women unless it is strictly necessary. If used during lactation, breastfeeding should be discontinued. Resumption of breastfeeding is possible within a day after the end of the course of treatment.
If the temperature rises while using interferon, you should take an antipyretic - the protein is alive at a temperature not higher than 37°C.
Interferon is not used when using antidepressants (increased effects).
Use the medicine with caution when working with machinery and driving vehicles.
Overdose
There were no cases of toxic effects of increased doses of the drug. In case of accidental intake large quantity substances, measures must be taken to remove them.
Side effects
The adverse effect can manifest itself in various problems.
- cardiological: arrhythmia, tachycardia and bradycardia;
- vascular: significant decrease blood pressure;
- digestive: loss of appetite, nausea, vomiting, diarrhea;
- nervous system: instability of consciousness, sleep disturbances;
- somatic: headaches, chills;
- mental: depression, decreased mood;
- skin: rash, itching skin, swelling
Composition and pharmacokinetics
In its pure form, interferon is contained in powdered ampoules - for dilution and irrigation or injection.
Suppositories, suppositories and ointments contain, in addition to interferon, a fatty base that gives a thick or hard consistency.
Interferons are produced from proteins of mammals, including humans, that have been exposed to the virus. Human leukocyte interferon is the most acceptable in composition; it absolutely excludes the content of pathogenic agents (including HIV and hepatitis).
The mechanism of action is to create a protective barrier of healthy cells around the site of infection, the permeability of which to the virus is insurmountable due to the influence of interferon. This prevents growth tumor formations– cells become unable to divide.
The action begins, depending on the method of administration, after 0.5 – 2 hours and lasts at least 6 hours, more often 12. The substance is completely and without a trace eliminated from the body within 24 hours from the last dose.
Storage and guarantees
The drug is stored in a dark and cool place. There is information that stored at room temperature the drug causes more side effects. Strictly unacceptable heat storage (above 37°C).
The shelf life of all drugs containing interferon is 2 years from the date of release. The opened drug (ampoule) and the prepared solution must be used within 3 days.
Human leukocyte interferon is available from pharmacies without a prescription.
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