Antigrippin pharmaceutical capsules instructions for use. Medicinal reference book geotar. Use in children

Dosage form: capsules Compound:

For one capsule:

Capsule A

active ingredients: ascorbic acid 300 mg, acetylsalicylic acid 250 mg, rutoside trihydrate (in terms of rutoside) 20 mg.

Excipients: calcium stearate 1.0 mg, potato starch 9.0 mg;

hard gelatin capsule: gelatin 90.723 mg, azorubine dye (E 122) 0.003 mg, brilliant black dye (E 151) 0.184 mg, proprietary blue dye (E 131) or brilliant blue dye (E 133) 0.315 mg, quinoline yellow dye (E 104) 2.207 mg , titanium dioxide (E 171) 2.560 mg.

Capsule B

active ingredients: metamizole sodium monohydrate 250 mg, calcium gluconate monohydrate 100 mg, diphenhydramine hydrochloride 20 mg;

Excipients: calcium stearate 3.8 mg, potato starch 6.2 mg;

hard gelatin capsule: gelatin 91.944 mg, titanium dioxide (E 171) 4.055 mg.

Description:

Capsules A - hard gelatin No. 0 green. The contents of the capsules are a mixture of crystalline and amorphous powder from light yellow to yellow with a greenish tint, the presence of lumps and single inclusions of a darker color is allowed.

Capsules B - hard gelatin No. 0 white. The contents of the capsules are a mixture of powder and granules of white or white with a yellowish tint, the presence of lumps is allowed.

Pharmacotherapeutic group:Acute respiratory infections and “cold” symptoms remedy ATX:

Other combination drugs used for colds

Pharmacodynamics:

A combined drug that has antipyretic, anti-inflammatory, analgesic, angioprotective, and anticongestive effects. The pharmacological activity of the drug is due to the properties active ingredients, included in its composition.

Acetylsalicylic acid suppresses anti-inflammatory factors, exudative and proliferative phases of inflammation due to inhibition of cyclogenase, inhibits the synthesis or inactivates inflammatory mediators. It has analgesic, antipyretic and anti-inflammatory effects, inhibits platelet aggregation.

Ascorbic acid takes part in many types of redox reactions in the body, inhibits the processes of peroxidation of lipids, proteins and other cell components, thereby protecting it from damage. increases the concentration of interferon in the blood, which is associated with its membrane-stabilizing effect and immunomodulatory effect. is able to accumulate in leukocytes, increasing their phagocytic activity, which increases antimicrobial and antiviral protection. Activates the biosynthesis of corticoid hormones in the adrenal cortex and thereby stimulates the body's adaptive processes under stress.

Rutoside angioprotective agent. Belongs to the group of bioflavonoids, which can be used to build biologically important compounds in the cell, in particular ubiquinone. Able to reduce capillary bleeding by strengthening the walls blood vessels, the permeability of which during viral infection increases. has a beneficial effect on maintaining normal level immune system.

Metamizole sodium- an analgesic non-narcotic drug, a pyrazolone derivative, non-selectively blocks COX (cyclooxygenase) and reduces the formation of prostaglandins from arachidonic acid. Prevents the conduction of pain impulses, increases the threshold of excitability of the thalamic centers of pain sensitivity, and increases heat transfer. It has an analgesic, antipyretic and some antispasmodic (in relation to the smooth muscles of the urinary and biliary tract) action.

Diphenhydramine - competitive blocker of H1-histamine receptors. It has pronounced antihistamine activity (weakens the body's response to endogenous and exogenous histamine). In addition, it has a local anesthetic effect, relaxes smooth muscles as a result of a direct antispasmodic effect, and blocks moderate degree cholinergic receptors of the autonomic nerve ganglia. Reduces capillary permeability, prevents histamine tissue swelling and histamine hypotension and thereby reduces vascular permeability, eliminates swelling and hyperemia of the nasal mucosa, sore throat, allergic reactions from the upper respiratory tract. Important feature Diphenhydramine is due to its sedative effect.

Calcium gluconate - Ca 2+ -containing drug. Calcium ions are necessary for the process of transmission of nerve impulses, contraction of skeletal and smooth muscles, activity of the heart muscle, formation bone tissue, blood clotting. Calcium ions reduce the permeability of cells and the vascular wall, preventing the development inflammatory reactions, increase the body's resistance to infections.

Indications:

Symptomatic treatment in adults of “colds”, acute respiratory viral infections and influenza, accompanied by fever, headache, chills, and nasal congestion.

Contraindications:

Hypersensitivity to the components of the drug; erosive and ulcerative lesions (in the acute phase) of the gastrointestinal tract; gastrointestinal bleeding; increased tendency to bleed; inhibition of hematopoiesis (agranulocytosis, neutropenia, leukopenia); hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase; hemorrhagic diathesis(hemophilia, von Willebrand disease, telangiectasia, thrombocytopenic purpura); hypoprothrombinemia; thrombocytopenia; vitamin K deficiency; bronchial asthma; diseases accompanied by bronchospasm; "aspirin asthma": severe liver or kidney dysfunction; hypercalcemia (calcium ion concentration should not exceed 12 mg% or 6 mEq/l); nephrolithiasis (calcium); calciuria; sarcoidosis; simultaneous use of cardiac glycosides (risk of arrhythmias); dissecting aortic aneurysm; portal hypertension; Glucose-6-phosphate dehydrogenase deficiency, pregnancy and period breastfeeding, children's and adolescence up to 18 years old.

Carefully:

Hyperuricemia, urate nephrolithiasis, gout, peptic ulcer stomach and/or duodenum(history), decompensated heart failure.

Pregnancy and lactation:

The use of the drug during pregnancy is contraindicated.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Directions for use and dosage:

Orally, after meals, with water, 2-3 times a day for 3-5 days until the symptoms of the disease disappear.

For adults Prescribe 2 capsules per dose: 1 green capsule (from blister A) and 1 white capsule (from blister B).

If you do not feel better after five days of use, you should stop taking the drug and consult a doctor.

Side effects:

Anorexia, nausea, vomiting, gastralgia, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding, hepatic and/or renal failure, increased blood pressure, tachycardia.

Allergic reactions: skin rash, Quincke's edema, bronchospasm.

At long-term use(more than 7 days) - dizziness, headache, visual impairment, tinnitus, leukopenia, thrombocytopenia, agranulocytosis; if you are prone to bronchospasm, it is possible to provoke an attack; decreased platelet aggregation, hypocoagulation, hemorrhagic syndrome (nose bleed, bleeding gums, purpura, etc.), kidney damage with papillary necrosis; deafness; anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome). Reye's syndrome (hyperpyrexia, metabolic acidosis, violations by nervous system and mental health, vomiting, liver dysfunction).

Possible renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, staining urine red due to the release of a metabolite.

All side (unusual) effects, including those not listed above, should be reported to your doctor and stop taking the drug.

Overdose:

Symptoms: nausea, vomiting, stomach pain, sweating, pallor skin, tachycardia. In case of mild intoxication - ringing in the ears; severe intoxication - drowsiness, collapse, convulsions, bronchospasm, difficulty breathing, anuria, bleeding, progressive respiratory paralysis and uncoupling of oxidative phosphorylation, causing respiratory acidosis.

If you suspect poisoning, you should immediately contact medical assistance.

Treatment: induce vomiting, do gastric lavage, take saline laxatives, . In conditions medical institution- carrying out forced diuresis, hemodialysis, with the development convulsive syndrome - intravenous administration diazepam and barbiturates.

Interaction:

If it is necessary to take it together with other medications, consult your doctor first.

Enhances the effect of heparin, orally oh an ticoagulants, reserpine, steroid hormones and hypoglycemic agents.

Reduces the effectiveness of spironolactone, furosemide, antihypertensive drugs, anti-gout drugs that promote excretion uric acid.

Strengthens side effects glucocorticosteroids, sulfonylurea derivatives, methotrexate, non-narcotic analgesics and non-steroidal anti-inflammatory drugs.

The combination of the drug with barbiturates, antiepileptic drugs, zidovudine, rifampicin and alcohol-containing drugs should be avoided (p and sk hepatotox ichecogO effect).

Ascorbic acid improves the absorption of iron preparations in the intestines.

Tricyclic antidepressants, contraception for oral administration and disrupt the metabolism of metamizole in the liver and increase its toxicity.

Metamizole sodium enhances the effects of alcohol-containing drinks.

Radiocontrast agents, colloidal blood substitutes and penicillin should not be used during treatment with metamizole sodium.

The simultaneous use of metamizole sodium with cyclosporine reduces the level of the latter in the blood.

Thiamazole also increases the risk of developing leukopenia.

Sedatives and tranquilizers enhance the analgesic effect of metamizole sodium.

Special instructions:

Since it has an antiaggregation effect, the patient, if he is to surgical intervention, must notify the doctor in advance about taking the drug.

Acetylsalicylic acid in low doses reduces the excretion of uric acid. This can in some cases provoke a gout attack.

During treatment, you should avoid drinking alcoholic beverages (increasing the risk of gastrointestinal bleeding).

Due to the stimulating effect ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor renal function and blood pressure.

Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process.

Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, liver transaminase activity, LDH).

Patients suffering from bronchial asthma and hay fever may develop hypersensitivity reactions.

Impact on the ability to drive vehicles. Wed and fur.:

When using the drug, care should be taken when driving and when engaging in other potentially hazardous activities that require increased concentration attention and speed of psychomotor reactions.

Release form/dosage:Capsules. Package:

Capsules A

Capsules B. 10 capsules in a blister pack.

2 blister packs (one with green capsules A, the second with white capsules B) along with instructions for use in a cardboard pack. Storage conditions:

In a dry place, protected from light, at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Best before date:

2 years.

Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies: Over the counter Registration number: LP-002908 Registration date: 13.03.2015 Expiration date: 13.03.2020 Owner of the Registration Certificate:PharmFirma SOTEX, JSC Russia Manufacturer: Representative office: PharmFirma SOTEX CJSC Russia Information update date: 06.09.2017 Illustrated instructions

Primary tumors arise from different brain tissues. The cause of uncontrolled cell proliferation has not been established. Secondary neoplasms are a consequence of a cancer process at any other location with metastases to the brain. Among the factors that increase the likelihood of the appearance of malignant tumors are:

some types of tumors (for example, medulloblastomas) usually develop in children, but most other brain tumors are registered after 45 years;
influence of radiation;
effects on the body of various chemical compounds;
family history;
In women, the risk of developing brain tumors increases when taking hormonal drugs and after stimulating the formation of eggs during the IVF procedure.

Depending on which cells began to divide uncontrollably, they distinguish the following types tumors:

from neuroepithelial tissues;
tumors of the cranial or spiral nerves;
tumor formations meninges;
lymphomas;
tumors from embryonic cells;
brushes;
tumors that develop in the area of the sella turcica;
formations that grow into the cranial cavity;
metastatic cancer;
tumors that are difficult to classify.

More than 50% of brain tumors are neuroectodermal formations. Among them are astrocytoma, ependymoblastoma, pineocytoma, neuroma and sympathoblastoma. It is important to note that brain tumors can be either benign or malignant. Benign formations reach a certain stage of development, after which they cease their activity and, unlike malignant structures, do not grow into surrounding tissues.

The classification of cerebellar tumors is based on the nature of growth and the quality of the overgrown tissue. Thus, the benign nature of the tumor implies slow growth and the absence of pronounced clinical symptoms. Tumors of this type include:

Malignant formations cerebellum are characterized by rapid growth and formation of metastases in various organs. Cancer requires urgent surgery. Medulloblastomas and sarcomas affecting the cerebellum are malignant.

A tumor of the cerebellum of the brain occupies 30% of the total share of neoplasms. Like other tumors of the nervous system, a cerebellar tumor can be primary or secondary. In the first case, the source of tumors is the lining of the brain or nerve cells, and in the second – tumor metastases of a different location.

According to the histological structure, tumors of the cerebellum of the brain are very diverse and there are more than 100 various types. But in practice, cancer metastases and

gliomas

cerebellum.

The latter occupy about 70% of the total number of neoplasms in the posterior cranial fossa. In young children they manifest themselves in the form of medulloblastomas, and in middle-aged and mature people - in the form of astrocytomas and angioreticularis. In elderly patients, metastases of cancer and glioblastoma are most often diagnosed.

The degree of danger and the principle of medical action depend on the type of neoplasia. Therefore, it is so important to identify its features. Types of cerebellar tumors are distinguished according to different principles.

Histological structure they are also heterogeneous. More than a hundred varieties are known.

Cerebellar gliomas are the most common. They make up about 70% of all neoplasms of the posterior cranial fossa:

V childhood histologically, the tumors are more likely to be medulloblastomas;
in older age, angioreticulomas and astrocytomas are more often formed;
in adulthood, the top priority is occupied by glioblastomas and cancer metastases.

Benign cerebellar tumors are characterized by slow growth. They are located in parts of the brain distant from healthy tissues, but can infiltrate neighboring tissues, and this is already unfavorable.

Cerebellar tumors are divided into benign and malignant. Neoplasm benign in nature weakly manifests itself, grows slowly. The neoplasm develops from cerebellar cells. It resembles a small node around which a large cystic cavity forms. Most cases of benign formations are hemangioblastomas and astrocytomas.

Malignant neoplasms are often medulloblastomas, sarcomas, and astroblastomas. Such brain lesions are characterized by instant growth and rapid spread to other parts of the meninges. The tumor affects the cerebellar vermis, the brain stem, which greatly affects the patient’s life. Cerebellar cancer often affects young patients. Without proper treatment of the tumor, the patient's life quickly becomes painful and death occurs.

Dangerous condition It is believed that cancer cells have damaged other membranes of the brain, making it difficult for fluid to leave the ventricular system. This happens on last stage cancer, doctors recognize the patient’s hopelessness and the impossibility of surgery.

The nature of the tumor is also divided into primary and secondary. The first case can be benign and malignant, the second is only malignant in origin. Primary tumors develop exclusively from cells of the cerebellar region, being localized in this region, but can spread to other brain structures. Secondary tumors begin in other systems of the body, spreading by metastases to the brain, affecting the cerebellum.

Regardless of the nature of the tumor, the formation increases, affecting others meninges, which worsens the patient’s quality of life. Pathological formations of the brain require prompt identification of the cause and treatment of the disease.

The brain is divided into 3 parts:

the anterior part is divided into two cerebral hemispheres; they contain the center for controlling the actions of the central nervous system. Each part of the brain directs the work of the opposite side;
the middle one is located in the central region of the skull, regulates central control reflexes (sleep, movement, steps, hunger, balancing the presence of fluid);
posterior is located behind the skull, has a center that controls arterial pressure, breathing movements, frequency heart rate, and the medulla oblongata.

The tumor can affect any function and reflex, forming in any part of the brain. In a benign course, the tumor develops from mature cells of various tissues. The malignant course begins with immature brain cells that entered it through the bloodstream (metastasis).

The causes of brain tumors are associated with genetics, racial predisposition, and age. Sometimes there are certain congenital disorders the structure of genes that contribute to the development of brain cancer in the future:

autosomal dominant Gorlin syndrome (basal cell carcinoma);
neurofibromatosis (Recklinghausen syndrome);
formation of a suppressor gene tumor process;
Li-Fraumeni syndrome.

Most often, glioma can be detected in children - low-grade astrocytoma. It appears due to the presence of Recklinghausen syndrome. Abnormal development of the child is common congenital etiology. The structure of DNA changes in early period by influencing multiple causes in external environment or the internal state of the body. Genetic predisposition increases the likelihood of developing malignant cancer brain.

To identify this brain tumor, it is necessary to conduct thorough neurological examinations. An important role here is played by an examination from an ophthalmological point of view, as well as the condition of the fundus. Use of modern radiation methods allow specialists to obtain the most accurate results.

When making this diagnosis, the manifestations of the disease are taken into account. The patient should also consult a neurologist.

Instrumental techniques include MRI, computed tomography and additional methods.

If you detect initial signs of a brain tumor, you should consult a doctor, he will prescribe biochemical analysis blood. On early stages An ophthalmologist can detect the problem by examining the fundus. You can go to several specialists to find out the cause of the disease. In order to specify the diagnosis, the following is carried out:

angiography of cerebral vessels;
computed tomography;
MRI – magnetic resonance imaging;
spinal tap;
electroencephalography;
PEC-CT – tomography using radioactive contrast.

The outcome of treatment directly depends on timely diagnosis. If in the development stage the effect is almost 85%, in advanced cases the survival rate after surgery is about 40%.

When found characteristic symptoms, a complete comprehensive examination brain, which will include:

Examination, consultation with relevant specialists (neurologist, neurosurgeon, ophthalmologist). Specialists will conduct a thorough examination of the patient’s medical history and listen to complaints. The doctor will prescribe a study using neuroimaging methods and conduct an instrumental examination. During the examination, sensitivity is checked facial nerves, mobility of the limbs, coordination of movements, condition of the optic nerves, fundus of the eye; according to the identified symptoms, an appropriate examination is prescribed.
Magnetic resonance imaging, CT in neurology. Allows you to see a broad picture of the disease, the localization of the pathological formation, damage to surrounding tissues and brain structures. The study allows us to determine the nature of the tumor process, which will affect tactics further treatment.
X-ray examination. Allows you to examine the state of the brain from the side of the tumor, determines the exact localization of the tumor.

Tumors of the cerebellum are easy to diagnose and can be easily detected during a qualitative examination. A brain tumor in the cerebellum will be successfully treated if it is detected in a timely manner.

To make a correct diagnosis, you need to consult a therapist, then consult a neurologist. The neurologist will carefully listen to the patient’s complaints, the history of their occurrence and the dynamics of their development.

A neurological examination will reveal a cerebellar symptom complex, including the following disorders:

muscle hypotension;
high tendon reflexes;
difficulties when performing coordination tests;
intellectual impairment.

An examination by an ophthalmologist is important, during which congestion in the fundus and disc edema are determined. optic nerve. The main role in diagnosis is played by instrumental methods neuroimaging. With the help of magnetic resonance imaging, a specialist will not only see the neoplasm of the cerebellar structures, but can also guess its nature.

So, adenoma and others benign tumors have clear contours and are characterized by slow growth. U malignant neoplasms blurred boundaries, swelling of the surrounding tissues is determined, they quickly increase in size. MRI also determines the size of the tumor, its location, and the patient’s prognosis for its further growth.

After tomography, targeted stereotactic intervention is often performed to take a section of altered brain tissue for histological examination.

Diagnosing a brain tumor can be difficult if it is located in hard to reach place. For this purpose, several are used at once various procedures, the results of which can not only confirm the presence of cancer cells in the patient, but also determine their structure and location.

Taking a general blood test is one of the methods for diagnosing a brain tumor

Among the diagnostic methods it is worth highlighting:

Examination by doctors: oncologist, neurosurgeon, neurologist;
Change general analyzes blood and urine;
Radiography. Able to display abnormal spots or darkening on brain images;
CT scan. Allows you to display images of various areas of the brain in order to identify the tumor site;
Magnetic resonance imaging. A more advanced and accurate method that allows you to assess the structure of the tumor;
Immunography. It is carried out by examining the patient’s blood for the presence of pathological indicators;
Biopsy. Depending on the location cancer cells this procedure is not always possible. This is the most reliable way to diagnose cancer, but if the risk of injury to healthy brain centers during its implementation is too great, it makes sense to focus on other methods.

To get more accurate results During a CT or MRI scan, the patient is injected with a special dye that improves the visibility of the tumor focus.

Related factors

Scientists have come to the conclusion that gender and race are the main factors in the occurrence and further development brain tumors. For example, out of the total number of patients, more males were identified. But when considering the types of tumors individually, several of them can be called “female.” Meningioma is a type of tumor, often identified among Negroid race, and the sign of brain cancer is in the Caucasian race.

Drug for symptomatic therapy acute respiratory diseases

Active ingredients

Diphenhydramine hydrochloride (diphenhydramine)
- (ascorbic acid)
- metamizole sodium (metamizole sodium)
- acetylsalicylic acid
- rutoside (in trihydrate form) (rutoside)
- calcium gluconate monohydrate (calcium gluconate)

Release form, composition and packaging

◊ Capsules two types.

Capsules A hard gelatin, size No. 0, green; the contents of the capsules are a mixture of crystalline and amorphous powder from light yellow to yellow with a greenish tint; The presence of lumps and single inclusions of a darker color is allowed (10 pcs. in a contour cell package).

Excipients: calcium stearate - 1 mg, potato starch - 9 mg.

gelatin - 90.723 mg, azorubine dye (E122) - 0.003 mg, brilliant black dye (E151) - 0.184 mg, proprietary blue dye (E131) or brilliant blue dye (E133) - 0.315 mg, quinoline yellow dye (E104) - 2.207 mg , titanium dioxide (E171) - 2.56 mg.

Capsules B hard gelatin, size No. 0, white; the contents of the capsules are a mixture of powder and granules of white or white with a yellowish tint; The presence of lumps is allowed (10 pieces in a contour cell package).

Excipients: calcium stearate - 3.8 mg, potato starch - 6.2 mg.

Composition of hard gelatin capsules: gelatin - 91.944 mg, titanium dioxide (E171) - 4.055 mg.

20 pcs. (10 capsules A green and 10 capsules B white) - contour cell packaging (2) - cardboard packs.

pharmachologic effect

A combined drug that has antipyretic, anti-inflammatory, analgesic, angioprotective, and anticongestive effects. The pharmacological activity of the drug is determined by the properties of the active substances included in its composition.

Acetylsalicylic acid suppresses anti-inflammatory factors, exudative and proliferative phases of inflammation due to inhibition of COX, inhibits the synthesis or inactivates inflammatory mediators. It has analgesic, antipyretic and anti-inflammatory effects, inhibits platelet aggregation.

Ascorbic acid takes part in many types of redox reactions in the body, inhibits the processes of peroxidation of lipids, proteins and other cell components, thereby protecting it from damage. Ascorbic acid increases the concentration in the blood, which is associated with its membrane-stabilizing effect and immunomodulatory effect. Ascorbic acid can accumulate in leukocytes, enhancing their phagocytic activity, which also increases antiviral protection. Activates the biosynthesis of corticoid hormones in the adrenal cortex and thereby stimulates the body's adaptive processes under stress.

Rutoside- angioprotective agent. Belongs to the group of bioflavonoids, which can be used to build biologically important compounds in the cell, in particular ubiquinone. Able to reduce capillary bleeding by strengthening the walls of blood vessels, the permeability of which increases during a viral infection. Rutoside has a beneficial effect on maintaining normal levels of the immune system.

Metamizole sodium- an analgesic non-narcotic drug, a pyrazolone derivative, non-selectively blocks COX and reduces the formation of prostaglandins from arachidonic acid. Prevents the conduction of pain impulses, increases the threshold of excitability of the thalamic centers of pain sensitivity, and increases heat transfer. It has an analgesic, antipyretic and some antispasmodic (in relation to the smooth muscles of the urinary and biliary tract) effect.

Diphenhydramine - competitive blocker of histamine H1 receptors. It has pronounced antihistamine activity (weakens the body's response to endogenous and exogenous histamine). In addition, it has a local anesthetic effect, relaxes smooth muscles as a result of a direct antispasmodic effect, and moderately blocks cholinergic receptors of the autonomic nerve nodes. Reduces capillary permeability, prevents tissue swelling and hypotension, thereby reducing vascular permeability, eliminating swelling and hyperemia of the nasal mucosa, sore throat, allergic reactions from the upper respiratory tract. An important feature of diphenhydramine is its sedative effect.

Calcium gluconate is a source of calcium ions, which are necessary for the transmission of nerve impulses, contraction of skeletal and smooth muscles, activity of the heart muscle, formation of bone tissue, and blood clotting. Calcium ions reduce the permeability of cells and the vascular wall, prevent the development of inflammatory reactions, and increase the body's resistance to infections.

Pharmacokinetics

Data on the pharmacokinetics of the drug Antigrippin pharmaceutical are not provided.

Indications

— symptomatic treatment in adults, influenza, ARVI, “colds” accompanied by fever, headache, chills, and nasal congestion.

Contraindications

- erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);

- gastrointestinal bleeding;

- increased tendency to bleeding;

- inhibition of hematopoiesis (agranulocytosis, neutropenia, leukopenia);

- hereditary hemolytic anemia (including those associated with deficiency of glucose-6-phosphate dehydrogenase);

- hemorrhagic diathesis (hemophilia, von Willebrand disease, telangiectasia, thrombocytopenic purpura, hypoprothrombinemia, thrombocytopenia);

— bronchial asthma and diseases accompanied by bronchospasm (including “aspirin” asthma);

- severe liver dysfunction;

- severe renal dysfunction;

— hypercalcemia (calcium ion concentration should not exceed 12 mg% or 6 meq/l);

— nephrolithiasis (calcium);

- hypercalciuria;

- sarcoidosis;

- simultaneous use of cardiac glycosides (risk of arrhythmia);

- dissecting aortic aneurysm;

- portal hypertension;

- deficiency of glucose-6-phosphate dehydrogenase;

- pregnancy;

- lactation period (breastfeeding);

- children and adolescents up to 18 years of age;

— increased sensitivity to the components of the drug.

WITH caution the drug is prescribed for hyperuricemia, urate nephrolithiasis, gout, gastric and duodenal ulcers (history), decompensated heart failure.

Dosage

The drug is taken orally, after meals, with water, 2-3 times a day for 3-5 days until the symptoms of the disease disappear.

For adults Prescribe 2 capsules per dose: 1 green capsule (from blister A) and 1 white capsule (from blister B).

The patient should be warned that if there is no improvement in well-being after 5 days of therapy, the drug should be stopped and consult a doctor.

Side effects

Allergic reactions: skin rash, Quincke's edema, bronchospasm.

From the outside of cardio-vascular system: increased blood pressure, tachycardia.

From the digestive system: anorexia, nausea, vomiting, gastralgia, diarrhea, erosive and ulcerative lesions of the gastrointestinal tract, gastrointestinal bleeding, liver failure.

renal failure.

Side effects observed with long-term use of the drug (more than 7 days)

From the side of the central nervous system: dizziness, headache.

From the senses: visual impairment, tinnitus, deafness.

From the hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis.

From the respiratory system: with a tendency to bronchospasm, an attack may be provoked.

From the blood coagulation system: decreased platelet aggregation, hypocoagulation, hemorrhagic syndrome (including nosebleeds, bleeding gums, purpura).

From the urinary system: kidney damage with papillary necrosis, renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, red staining of urine due to the release of a metabolite.

Allergic reactions: anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).

Others: Reye's syndrome (hyperpyrexia, metabolic acidosis, nervous system and mental disorders, vomiting, liver dysfunction).

The patient should be warned that all side effects, incl. not listed above, you should inform your doctor and stop taking the drug.

Overdose

Symptoms: nausea, vomiting, stomach pain, sweating, pale skin, tachycardia; with a slight overdose - ringing in the ears; in case of severe overdose - drowsiness, collapse, convulsions, bronchospasm, difficulty breathing, anuria, bleeding, progressive respiratory paralysis and respiratory acidosis.

Treatment: artificial vomiting, gastric lavage, administration of saline laxatives, activated carbon; with the development of convulsive syndrome - intravenous administration of diazepam and barbiturates; if necessary, forced diuresis and hemodialysis.

Drug interactions

With simultaneous use, Antigrippin pharmaceutical enhances the effect of heparin, oral anticoagulants, reserpine, steroid hormones and hypoglycemic agents.

With simultaneous use, Antigrippin pharmaceutical reduces the effectiveness of spironolactone, furosemide, antihypertensive and uricosuric drugs.

Strengthens adverse reactions GCS, sulfonylurea derivatives, methotrexate, non-narcotic analgesics and NSAIDs.

With simultaneous use of the drug with barbiturates, antiepileptic drugs, zidovudine, rifampicin and ethanol-containing drugs, the risk of hepatotoxicity increases. These combinations should be avoided.

Ascorbic acid improves the absorption of iron preparations in the intestines.

Tricyclic antidepressants, oral contraceptives and allopurinol disrupt the metabolism of metamizole in the liver and increase its toxicity.

Metamizole sodium enhances the effects of alcohol-containing drinks.

The simultaneous use of metamizole sodium with cyclosporine reduces the level of the latter in the blood plasma.

When used simultaneously with metamizole sodium, thiamazole and melphalan increase the risk of developing leukopenia.

Sedatives and tranquilizers enhance the analgesic effect of metamizole sodium.

Radiocontrast agents, colloidal blood substitutes and penicillin should not be used during therapy with metamizole sodium.

special instructions

Since acetylsalicylic acid has an antiplatelet effect, the patient, if he is undergoing surgery, must notify the doctor in advance about taking the drug.

Acetylsalicylic acid in low doses reduces the excretion of uric acid, which can in some cases provoke a gout attack.

While using the drug, patients should avoid drinking alcoholic beverages due to increased risk development of gastrointestinal bleeding.

Due to the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor renal function and blood pressure.

Prescribing ascorbic acid to patients with rapidly proliferating and intensively metastasizing tumors can aggravate the process.

Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (determination of glucose, bilirubin, liver transaminase activity, LDH in blood plasma).

In patients with bronchial asthma and hay fever, hypersensitivity reactions may develop when taking the drug.

Impact on the ability to drive vehicles and operate machinery

During the period of use of the drug, care should be taken when driving vehicles and engaging in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

For liver dysfunction

Contraindicated in severe violations liver function and portal hypertension.

Conditions for dispensing from pharmacies

The drug is approved for use as a means of OTC.

Storage conditions and periods

The drug should be stored out of the reach of children, in a dry, dark place at a temperature not exceeding 25°C. Shelf life – 2 years.

Such a nuisance as acute respiratory diseases can happen to each of us at any time of the year. Most often, we suffer not from an attack of colds, but from infection by viruses, which not only greatly worsen our general state, but are also fraught with the development of a variety of complications. Of course they are pathological conditions They should not be ignored; it is best to treat them under the supervision of a doctor. Therapy for acute respiratory infections and acute respiratory viral infections, including influenza, may include the use of a variety of medicinal formulations, including Antigrippin (powder).

What is the effect of Antigrippin?

Antigrippin is a complex medicinal composition that can relieve fever and eliminate inflammatory processes. In addition, this remedy is good at eliminating swelling of the mucous membranes in the nasal cavity, coping with allergies and other cold symptoms.

What is the composition of Antigrippin?

Pharmacy powder Antigrippin contains paracetamol, vitamin C or in other words ascorbic acid, as well as chlorpheniramine maleate. Paracetamol is an anti-inflammatory drug that can eliminate unpleasant painful sensations and also reduce elevated temperature bodies. A component of this medication, chlorpheniramine maleate, is essentially a blocker of H1-histamine receptors; it copes with allergy symptoms and has sedative qualities. In addition, its consumption leads to a decrease in mucus production. Chlorphenamine also helps to greatly facilitate the processes of nasal breathing, reduce the feeling of nasal congestion, relieve the patient from sneezing, watery eyes, itching and redness of the eyes.

Ascorbic acid is a strong antioxidant; it stimulates the immune system and reduces vascular permeability. Vitamin C also takes an active part in the regulation of redox processes and is important for the normal course of carbohydrate metabolism.

One packet of Antigrippin powder contains five hundred milligrams of paracetamol, ten milligrams of chlorphenamine maleate and two hundred milligrams of ascorbic acid.

The drug can be purchased in two different forms– with honey-lemon or chamomile flavor.

What are Antigrippin's indications for use?

Antigrippin can be used in the treatment of various infectious and inflammatory diseases, for example, various types of acute respiratory viral infections and influenza, which are accompanied by fever, chills and headaches, aching joints and muscles, as well as nasal congestion and painful sensations in the throat and sinuses area.

What are the uses and dosage of Antigrippin?

This medicine is suitable for the treatment of adults and children over fifteen years of age. In this case, you are allowed to consume no more than two or three sachets of the drug per day. The medicine powder should be completely dissolved in one glass of slightly warmed water (not higher than fifty to sixty degrees). The prepared composition should be drunk immediately. It is highly recommended to consume the solution between meals.

Between appointments medicinal composition an interval of at least four hours must be observed.

If the patient has problems with the liver or kidneys, or his age has exceeded fifty years, then the interval between doses of the medication should be at least eight hours.

The duration of consumption without consulting a doctor should not exceed five days if the medicine is used for pain relief. When temperature is corrected, this period is reduced to three days.

What are the contraindications for use of Antigrippin?

Antigrippin powder instructions for use do not allow use if the patient has excessive sensitivity to any of its components. Also, this drug is not used in the treatment of patients with erosive and ulcerative lesions. digestive tract at the stage of exacerbation, expressed by the form of renal or liver failure. This medication is not suitable for patients with alcoholism, angle-closure glaucoma, phenylketonuria, hyperplasia prostate gland. Antigrippin is not commonly used in the treatment of children under fifteen years of age; in addition, its use is contraindicated when carrying a child, as well as during breastfeeding.

Particular care should be taken in case of renal or hepatic failure, congenital hyperbilirubinemia, lack of glucose-6-phosphate dehydrogenase, viral hepatitis, alcoholic hepatitis and in old age.

What are the side effects of Antigrippin?

Antigrippin extremely rarely causes side effects; in most cases, it is quite well tolerated by the body. However, in some cases, its consumption can lead to headaches and fatigue, provoke nausea and pain in the epigastric region. The development of hypoglycemia, anemia and hemolytic anemia is extremely rare, and thrombocytopenia is even rarer. In some cases, Antigrippin provokes various types of allergic reactions, including skin rashes, itching sensations, urticaria, Quincke's edema, etc. Some patients experience the development of hypervitaminosis C, metabolic problems, a feeling of heat and dryness in the oral cavity. Sometimes accommodation paresis, excessive drowsiness and urinary retention may occur.

The appearance of any side effect should be considered as a reason for immediate consultation with a doctor.