One tablet contains:
Active substance: disulfiram - 150 mg.
Excipients: potato starch - 2.70 mg, microcrystalline cellulose - 23.80 mg, colloidal silicon dioxide - 0.85 mg, croscarmellose sodium - 0.85 mg, stearic acid - 0.36 mg, magnesium stearate - 1.44 mg.
Description: Round, flat-cylindrical tablets of white or white with a slightly yellowish-greenish tint, with a bevel. Pharmacotherapeutic group:Drug for the treatment of alcoholism ATX:N.07.B.B.01 Disulfiram
Pharmacodynamics:Disulfiram inhibits the enzyme acetaldehyde dehydrogenase involved in the metabolism of ethanol, which leads to an increase in the concentration of acetaldehyde, which is a metabolite of ethanol, by 5-10 times. Acetaldehyde causes a number of unpleasant sensations: “flushes” of blood to the skin of the face, nausea, vomiting, a feeling of malaise, tachycardia, and a decrease in blood pressure. As a result, a conditioned reflex reaction of disgust to the taste and smell of alcoholic beverages is developed. The strength of the reactions caused by the drug is proportional to the dose taken.
Pharmacokinetics:Absorption after oral administration is 70-90%. It is rapidly metabolized in the liver by reduction to diethyldithiocarbamate, excreted as a glucuronide by the kidneys, or transformed into diethylamine and carbon disulfide, the proportion of which varies from 4 to 53%. The latter is excreted through the lungs. The minimum content of disulfiram in the blood is about 20 ng/ml. Indications: used as adjuvant therapy chronic alcoholism in patients undergoing treatment for alcohol dependence who intend to remain abstinent from alcohol in order to achieve best effect supportive and psychotherapy. does not cure alcoholism. When used as monotherapy, without appropriate motivation and supportive treatment, it does not have a significant effect on alcoholic behavior in persons with chronic alcoholism. Contraindications:Hypersensitivity, thyrotoxicosis, diseases of the cardiovascular system (including pronounced cardiosclerosis, atherosclerosis cerebral vessels, severe myocardial damage, pre- and post-infarction conditions, aortic aneurysm, occlusion coronary vessels, arterial hypertension II-III stages and other diseases of the cardiovascular system in the stage of decompensation), chronic obstructive pulmonary disease, pulmonary tuberculosis with hemoptysis, bronchial asthma, severe pulmonary emphysema, erosive lesions mucous membrane of the gastrointestinal tract, gastric ulcer and duodenum(in the acute stage), bleeding from the gastrointestinal tract, kidney disease, liver failure, diabetes, epilepsy, infectious diseases central nervous system, polyneuropathy, acoustic neuritis and ocular nerves, glaucoma, malignant tumors, pregnancy, lactation period. In some cases, when long-term use Teturam may experience acute psychosis resembling acute alcoholic paranoid, acute alcoholic hallucinosis or alcoholic delirium. It is possible for a hallucinatory syndrome to transform into paranoid, paranoid into schizophrenia-like, etc.
Simultaneous (or in the recent past) use of metronidazole, paraldehyde, ethanol or ethanol-containing drugs and products. Childhood up to 18 years old.
Carefully:Patients over the age of 60 years, peptic ulcer of the stomach and duodenum (in remission), endarteritis, residual effects of the disorder cerebral circulation, psychosis while taking disulfiram in the anamnesis. Pregnancy and lactation:The use of the drug is contraindicated during pregnancy and breastfeeding. Directions for use and dosage:Before starting treatment, the duration of abstinence from drinking alcohol should be at least 12 hours. Dosage regimen at the beginning of therapy During the first 1-2 weeks of treatment single dose disulfiram should be no more than 500 mg/day. The drug is taken in the morning on an empty stomach, before breakfast. It is usually taken in the morning, but if sedation occurs, the drug may be prescribed at night. To minimize or eliminate sedative effect, the dose can be adjusted downward.
Maintenance therapy The average maintenance dose is 250 mg/s (range 125 to 500 mg), maximum daily dose 500 mg.
Duration of therapy Regular daily use of disulfiram should be continued until full recovery patient when he can self-monitor his alcohol consumption. The drug should be continued until stable remission is achieved.
Side effects:“Metallic” taste in the mouth, unpleasant odor (caused by carbon disulfide) in patients with colostomy, hepatitis, neuritis optic nerve, peripheral neuritis, polyneuropathy of the lower extremities, neuropsychiatric disorders, memory loss, disorientation in time and space, asthenic syndrome, headache, skin allergic reactions. Side effects caused by the association of disulfiramethanol: collapse, arrhythmia, angina pectoris, myocardial infarction, cerebral edema, cerebral hemorrhage. Overdose:Symptoms: confusion, collapse, coma, neurological complications.
There is no specific treatment for disulfiram overdose. For severe disulfiram-alcohol reaction lasting 1.5 hours, oxygen therapy, inhalation of carbogen (a mixture of 95% oxygen and 5% carbon dioxide) are used, high doses are administered intravenously ascorbic acid(up to 1 g), ephedrine sulfate and antihistamines. Serum potassium concentrations should be monitored, especially if the patient is taking digitalis preparations.
Interaction:Disulfiram should be prescribed with caution to patients taking its derivatives, since simultaneous administration drugs can lead to phenytoin intoxication. Before prescribing disulfiram, patients taking phenytoin should determine the baseline level of phenytoin in the blood serum and subsequently monitor the level of phenytoin in the blood in order to adjust the dose of the drug. enhances the effect of indirect anticoagulants and increases the risk of bleeding. In case of simultaneous administration with oral anticoagulants, it is necessary to monitor prothrombin levels more frequently and adjust the doses of anticoagulants. It is also necessary to adjust the dose of disulfiram at the beginning and after completion of the course of therapy, as it may prolong the prothrombin time. Effects of disulfiram, incl. neurotoxic, potentiated by tricyclic antidepressants (),. increases the risk of developing mental disorders and delirium.
When administered concomitantly with isoniazid, the risk of behavioral disorders and motor coordination increases. If these signs are detected, disulfirs should be discontinued. increases the plasma concentration of drugs metabolized in the liver due to inhibition of microsomal liver enzymes. Strengthens toxic effects phenazone, chlordiazepoxide and diazepam by inhibiting their metabolism. reduces the reaction to.
Special instructions:Under no circumstances should the drug be taken in a state of alcohol intoxication. It is unacceptable to prescribe the drug without notifying the patient. The patient's relatives should be instructed by the doctor about the specifics of using the drug.
Disulfiram should be used with extreme caution in the following conditions: concomitant diseases: diabetes mellitus, hypothyroidism, epilepsy, chronic and acute nephritis, as well as in patients over 65 years of age. Data on hepatotoxicity of the drug, including liver failure requiring liver transplantation or resulting in death, have been reported. Severe and sometimes fatal hepatitis caused by disulfiram therapy may develop many months after drug treatment is completed. The patient must be warned about the need to inform the doctor about all early symptoms manifestations of hepatitis, such as fast fatiguability, weakness, malaise, loss of appetite, nausea, vomiting, jaundice, dark urine. Every 10-14 days from the start of disulfiram therapy, the patient should undergo a control study of liver function parameters, including general and biochemical analysis blood.
Patients taking it should not be exposed to ethylene dibromide and its vapors. Results from studies in rats have demonstrated that inhalation of ethylene dibromide during disulfiram administration increases tumor development and mortality in rats. There are no similar data on the effects of diethyl bromide vapor on patients. Reaction between alcohol and disulfiram:
The patient should be informed of all the consequences of drinking alcohol during treatment with disulfiram. The patient should be warned about the inadmissibility of secret consumption of alcohol, as well as alcohol in the composition food products(sauces), medicines (alcohol-containing medicines), perfumes. Drinking alcohol simultaneously with disulfiram, even in small quantities, causes redness of the face, pulsation in the head and neck, pulsating headache, difficulty breathing, nausea, profuse vomiting, sweating, thirst, chest pain, increased heart rate, shortness of breath, decreased blood pressure, weakness, confusion and loss of consciousness, severe anxiety, dizziness, blurred vision. IN severe cases Respiratory depression, cardiovascular failure, seizures, and death may occur.
Alcohol addiction is a serious illness that is impossible to cope with on your own. To get rid of it and get it back normal life, and your loved ones peace and joy, you need to fight and remember that the price of every gram of alcohol is the destruction of fate. Specialists and medications, for example, Teturam, can help in this matter. Reviews speak of it as the most effective means.
Composition, purpose, action
The composition of the drug does not include big list components. This medicinal product, which includes:
- Disulfiram – 150 ml.
- Starch.
- Silica.
- Stearic acid.
How does the medicine work? The tablets have pharmacological action- block alcohol dehydrogenase. Teturam is prescribed for treatment chronic addiction from alcohol, preventive measures to avoid relapses of alcoholism and as a medicine for detoxification when the body is poisoned with nickel.
The medicine suppresses the production of an enzyme in the liver (acetaldehyde), which is necessary for the breakdown of alcohol. Acetaldehyde accumulates in the body and causes intoxication. Nausea, vomiting, and redness of the epidermis appear. Breathing becomes difficult, arrhythmia occurs, and a feeling of fear occurs.
The action of Teturam is aimed at causing a negative reaction to alcoholic drinks in the patient. After treatment, a person will not be able to tolerate not only the smell and taste of alcohol, but will be unable to even look at it. He will feel sick when he tries to drink a little.
Who should not use the medicine
Teturam tablets are prescribed with caution to people of advanced age (after 60 years) suffering from inflammation inner surface vessels who have suffered a stroke, with residual consequences of cerebral circulatory disorders, psychoses caused by disulfiram. The drug is strictly contraindicated for:
Features of treatment
The drug must be taken under the strict supervision of a physician. Treatment begins only with the consent of the patient and his relatives. The patient must refrain from drinking alcohol during therapy. Then the person who decides to quit the addiction with the help of this medication goes through thorough examination. He is warned about possible consequences, if the rules of therapy are not followed. The doctor prescribes Teturam tablets individually, determining the quantity and time of administration. As a rule, the initial dose is 0.25-0.5 g per day.
Tests are carried out over 8-10 days, after which the dosage is adjusted. The test is carried out as follows: after taking the medicine, the patient is given 20-30 milliliters of vodka. If the reaction to vodka is not strong, the dosage of the medicine is increased by 10-20 milligrams. After a couple of days the test is repeated. After 4-5 days, the test is performed on an outpatient basis and adjusted again. The correct dosage of Teturam (150-200 milligrams per day) can be used from 1 year to 3 years, depending on the duration of treatment, during which the dose is gradually reduced. Instructions for use recommend taking the tablets in the morning, on an empty stomach.
During tryouts, before the start individual treatment The patient may experience signs of alcohol intolerance. Teturam tablets are absolutely safe for health, this is confirmed by the instructions for use and the composition of the drug, but in combination with alcohol a severe reaction occurs, even death. Also, a reaction can occur due to negligence when taking the medicine Teturam and consuming such products as:
- Sauerkraut.
- Tea mushroom.
- Kvass.
That is why reviews from doctors warn about the consequences of treatment and require the most precise adherence to the rules. The price of 1 package of 30 tablets is a little more than 100 rubles, the price of 50 tablets is 150-170 rubles.
The second treatment option for alcoholism is implantation. Teturam is used as an implant. It happens like this: disinfection is carried out in the left iliac zone and local anesthesia. Then a 6 mm incision is made. Two tablets are inserted into the incision, going 4 centimeters deep, a suture is applied and sterile pad. The procedure is performed at least four times.
Possible complications and adverse reactions
After completing therapy, doctors do not recommend returning to alcohol abuse. Their reviews indicate the possibility serious complications. If you stumble again, the price will be your health. The functioning of the central nervous system is disrupted, and the risk of developing a heart attack and thrombophlebitis increases. The appearance of hallucinations and psychosis is possible. With long-term therapy with Teturam, there may be side effects:
In rare cases, reviews indicate the appearance of fear, delirium, and prolonged agitation. The use of the medication must be accompanied by information and consent of the patient, also for the purpose of psychological preparation for a change in lifestyle. He should be warned about the consequences of drinking alcohol during such treatment, but also know that there is another, happy life without a shot glass.
If you mix pills without his knowledge, a person can take alcohol and get serious health problems or become stressed and depressed. This state is possible because the psyche drinking man very loose.
Treatment of alcoholism with Teturam requires a lot of time and close medical supervision, but the main rule of successful therapy is the person’s desire to give up the craving for alcohol.
Recovery from alcoholism is quite possible if you start attacking it in the early stages and act in accordance with the doctor’s instructions, as well as if the sick person sincerely desires to return to normal life. healthy image life. The main treatment assistance is provided by medications, among which one of the best drugs are Teturam tablets. You can verify this by reading numerous reviews from practitioners. for a long time addiction specialists, as well as treated patients - former victims of alcohol
In the article:
Oral and subcutaneous
Teturam effectively help fight against chronic form alcoholism thanks to the active substance disulfiram in the composition. These agents can be taken orally and implanted under the skin. In the first case, the active substance, accumulating in the blood, inhibits the breakdown of ethyl alcohol in the body, which leads to an increase in the volume of toxic acetaldehyde in the blood. If after this a person drinks alcohol-containing drinks, its mixture with the medicine poisons the body with the manifestation of the corresponding symptoms. Thus, oral tablets teach the drunkard to experience an aversion to alcohol, its very appearance, taste and smell.
Means for “sewing in” under the skin provide the same effect, the only exception is that, implanted under the skin, they maintain the required amount of the active substance in the body, which ensures a longer-lasting effect. The instructions suggest that any measures for the use of Teturam should be carried out only under the supervision of a specialist, with the patient fully aware of the potential dangers. Here are some reviews on this topic:
Maxim, Moscow:
“Never self-medicate...! Teturam is taken in combination to increase the effectiveness of other medications in order to consolidate success in the first stages of the war against alcohol addiction! It’s worth taking care of your health - it’s more valuable than money!”
Konstantin, Volgograd:
“The product is excellent, it can really help... the main condition is to have a consultation with a specialist so as not to run into an individual allergic intolerance. You cannot drink and take medicine at the same time, and even after the course of treatment (at least during the first week) it is dangerous to drink alcohol. Yes, dear loving wives: just don’t think of secretly mixing this into food - it’s extremely dangerous for life! A drunkard must use pills consciously.”
Mikhail, Moscow:
“My wife disguised this medicine as general health-improving “vitamins.” I swallowed a tablet in the morning at 10 o’clock, then “persuaded” 50 grams of vodka. Result: the pressure jumped to 187 over 100 with a pulse of 115, we had to disturb the ambulance.” Alexander, Khabarovsk:
“If a person accidentally takes a sip of alcohol while using the tablets, let him be prepared for harmful and dangerous consequences! ... In fact, without these consequences, which are a factor in restraining the desire to drink alcohol, there is no way to get rid of alcohol addiction. And the worst thing is that you can’t predict what the consequences will be; everything is decided by the state of the body and psyche. Anything is possible, even death.”
Potential Hazards
The drug is contraindicated for many diseases, including different kinds oncology, cardiovascular diseases and endocrine system, diseases of the lungs, hematopoiesis and gastrointestinal tract. Find out if you can take it this medicine, only a doctor can, as well as instructions for use. About what happens if this rule is not followed, relevant reviews:
Elena, St. Petersburg:
“One tablet was enough for, after a simple glass of beer, a rash covered his entire face and [the husband] began to choke. Everything turned out okay, but I don’t risk giving any more, I suddenly felt scared.”
Zhanna, Khabarovsk:
“My brother (age 50 years old) drank Teturam. I swallowed a glass of wine while I was visiting, and within an hour I lost consciousness, vomited, and my temperature rose. They were taken by ambulance to the hospital with the final diagnosis - ischemic stroke left side of the body." 
Galina, Barnaul:
“The result is obvious, it was tested on my uncle, whose other half secretly slipped it into his food. Everything was going fine until my uncle got back to his old ways - as soon as he drank a glass, he immediately became ill - he became covered in red spots, he was shaking all over. While I didn’t know about the treatment, I blamed everything on the vodka—scorched, supposedly. But one day, after drinking a glass of vodka, my uncle became very ill - his blood pressure began to go off scale, his pulse began to increase, his face turned pale, and he had to urgently call an ambulance. Thank God we were able to pump it out.”
Not without your own willpower
The effect of treatment for alcohol addiction, which Teturam tablets help to carry out, is not long enough if it is not supported by the patient’s own efforts and willpower. The opposite is also true - the longer a drunkard stays in shape thanks to the medicine, the stronger his self-confidence. The following reviews are about this.
Alexander, Moscow:
“Teturam is an unusually strong stimulant, but only if there is own desire stop drinking!!! Yes, in fact, such a desire disappears on its own, since when you “drink” alcohol and Teturam together, such things begin to happen to your health... But if there is no personal desire to be cured, then two weeks pass after the course - and your health allows you to drink again!”
Alexander, Barnaul:
“The drug is very good, provided that the drunkard himself is determined to get rid of the craving for alcohol.”
Inna, Moscow:
“A friend once told me that her husband took a course of Teturam as prescribed by a doctor. He recovered after 10 years of heavy drinking, became a completely different person, and for six months he didn’t take a drop of alcohol in his mouth. The specialist said that for successful treatment There was one mandatory condition: consent to take the medicine of your own free will.
Opinions are positive and not too
Each person is individual, each has their own “limit” of health and stamina, which allows them to maintain sobriety in the process of struggling with alcohol addiction. It is therefore not surprising that opinions about Teturama range from extremely positive to completely negative. This in no way speaks about the quality of the drug - only about its effect on specific patients.
Alexandra, Voronezh:
“Again my husband started drinking the bottle. One of the means of struggle was separation: she kicked him out, more than once. One day, after long and painful conversations, we decided to seek medical help, and my husband deliberately went to drug addiction specialists. We received a prescription for the familiar Teturam tablets. After a two-week course of treatment, they seemed to feel relief. My husband has stopped binge drinking and hasn’t drunk alcohol for, in my opinion, more than two months.
Tatyana, Moscow:
“I didn’t notice any effect - my friend took a pill every morning for 4 days in a row, but he didn’t stop abusing it.”
Victoria, Rostov-on-Don:
“The main effect of Teturam is to “knock down” the craving for alcohol. To do this, some are prescribed one tablet a day, some - two or three. My husband drank two of them. What can I say, the remedy didn’t help that much, the cravings didn’t disappear, but “side effects” appeared, and they were serious. The body begins to burn, red as a beet, the heart is fluttering, the head is spinning, and nausea. So it is only because of the fear of side effects of the pill that the craving for alcohol stops. My opinion: it will help some, but not others.” 
Andrey, Moscow:
“The drug is 100% good, except for one “small” drawback - a serious list of contraindications and adverse effects. I would not advise anyone to treat them without visiting a doctor and a preliminary examination.”
Tatyana, Lipetsk:
“One relative uses these pills from time to time if he doesn’t have the willpower to quit a long binge on his own. Strictly speaking, the principle of action of these tablets is simple: if you risk drinking alcohol during the course of treatment with the drug, the body will produce a violent reaction in the form of nausea, vomiting, red spots on the body, and tachycardia. All these symptoms lead to aversion from alcohol.”
Alexander, Moscow:
“For the life of me, I won’t believe it, pills will be enough to rid a serious alcoholic of addiction. No, it may, of course, be the case that the pills will help cure, but only as a aids. I personally know people who are able to resist not only pills, but even the most powerful coding.”
The choice is obvious
Even if the drug Teturam had only positive reviews, it would still be impossible to use it without a doctor’s prescription and determination of the dose that is optimal from the point of view of benefit and harmlessness. There is too great a danger of causing side effects or, on the contrary, of giving the patient a dose of medication that is too small for the therapeutic effect. In general, reviews are worth reading, but you should still rely on the opinion of a real practitioner.
Svetlana, St. Petersburg:
“My review is this: it works, but to achieve a truly powerful effect, you don’t just need to drink it blindly. Positive reactions it is necessary to reinforce and guide. Remedies for alcoholism do not work the same way as drugs, for example, for headaches - you drink, and there are no problems. In the case of treatment for alcoholism, an individual approach is important, naturally, with the participation of a specialist narcologist. And, of course, in order for the treatment not to be useless, the appropriate attitude of the drinking person is necessary.”
Clinical and pharmacological group
A drug for the treatment of alcohol addiction..
Terms of sale from pharmacies
Can be purchased with a doctor's prescription.
Price
How much does Teturam cost in pharmacies? average price is at the level of 220 rubles.
Composition and release form
Teturam tablets are available in 0.15 and 0.25 g in packs of 50 or 30 pieces, as well as powder substance.
- The main active ingredient of Teturam is disulfiram.
In addition, it contains the following additional components: potato starch, povidone, primellose, colloidal silicon dioxide, stearic acid.
pharmachologic effect
Once in the body, Teturam acts as an inhibitor of altaldehyde dehydrogenase, an enzyme that takes part in the metabolism of ethanol. As a result, the level of acetaldehyde in the blood increases.
This causes symptoms of intoxication:
- heart rhythm disturbance;
- chills;
- chest pain;
- facial redness;
- nausea with vomiting;
- general weakness;
- decreased blood pressure;
- difficulty breathing.
Because of similar symptoms Drinking alcohol ceases to give a person pleasure. Gradually he completely stops drinking alcohol.
After taking Teturam tablet orally active substance Quite quickly and almost completely absorbed into the systemic bloodstream from the intestine (bioavailability is 70-90%). It is evenly distributed in tissues, metabolized in the liver with the formation of inactive breakdown products, which are excreted from the body mainly in the urine.
Indications for use
The product is used as effective method prevention of chronic alcoholism. Teturam can be used as a drug that guarantees the absence of relapses during the main treatment with other specific methods. The remedy can be used by loved ones both in secret from the alcoholic, and used consciously by a drinker.
The active ingredient Teturam - disulfiram is an antidote to nickel, for this reason the drug can be used for detoxification in case of poisoning with this metal.
Contraindications
Absolute:
- Malignant tumors;
- Liver failure and kidney disease;
- Diabetes;
- Thyrotoxicosis;
- Glaucoma;
- Pregnancy;
- Lactation period;
- Hypersensitivity;
- Bleeding from gastrointestinal tract(GIT), erosive lesions of the gastrointestinal mucosa, exacerbation peptic ulcer stomach or duodenum;
- Severe pulmonary emphysema, bronchial asthma, pulmonary tuberculosis with hemoptysis;
- Diseases of cardio-vascular system in the stage of decompensation (including atherosclerosis of cerebral vessels, pronounced cardiosclerosis, coronary
- insufficiency, aortic aneurysm, pre- and post-infarction conditions, arterial hypertension stages II–III);
Neuritis of the auditory and optic nerves, polyneuropathy, neuropsychiatric diseases, epilepsy, infectious diseases of the central nervous system.
Relative (special care is required when using):
- Peptic ulcer of the stomach and duodenum in remission;
- Cardiovascular diseases in the compensation stage;
- Endarteritis;
- History of psychosis due to taking disulfiram;
- Residual effects of cerebrovascular accident;
- Age over 60 years.
Dosage and method of administration
As indicated in the instructions for use, Teturam tablets are taken orally. The drug is prescribed after complete medical examination, the doctor must warn the patient about possible consequences and complications.
- Recommended dosage: according to an individual regimen from 150 to 500 mg 2 times a day. Teturam-alcohol test is carried out after 7-10 days of therapy; it consists of the patient taking 20-30 ml of vodka (40%) after 500 mg of the drug. In case of a weak reaction, the amount of vodka is increased by 10–20 ml. The dose of alcohol should not exceed 120 mg.
Repeated tests with adjustment of doses of alcohol and/or drug are carried out after 1–2 days in the hospital and after 3–5 days on an outpatient basis. Maintenance therapy at a daily dose of 150–200 mg can continue for 1–3 years.
Tetra-alcohol tests must be carried out under the supervision of a physician, since it is impossible to predict the reaction to alcohol in each specific case. Often a person experiences severe, poorly tolerated sensations that require quick fix. To relieve painful and excessive reactions during tetra-alcohol tests, a number of medications are used, most of which are administered intravenously or intramuscularly. It is precisely because of the likelihood of such an intervention that the doctor must be present and monitor the progress of the alcohol test.
Side effects
While using the drug Teturam, the following side effects may occur:
- cerebral edema;
- memory impairment;
- headache;
- collapse;
- myocardial infarction;
- skin rash;
- angina pectoris;
- metallic or bitter taste in the mouth;
- insomnia;
- angioedema;
- arrhythmia;
- anxiety and fear;
- hives;
- tachycardia;
- dizziness;
- bronchospasm;
- convulsions;
- psychoses;
- gastritis;
- confusion;
- optic neuritis;
- hepatitis;
- difficulty breathing.
Overdose
In case of an overdose of the drug, neurological complications, depression of consciousness up to coma, and cardiovascular collapse are possible. Therapy is symptomatic.
special instructions
Use with caution in patients with renal failure, liver disease, and respiratory system.
Interaction with other drugs
When using the drug, it is necessary to take into account interactions with other medications:
- When used simultaneously with isoniazid, cases of dizziness and depression have been described; with caffeine - the excretion of caffeine from the body decreases; with metronidazole - acute psychosis and confusion develop; with omeprazole - a case of the development of impaired consciousness and catatonia is described.
- When used concomitantly with perphenazine, the development of psychotic symptoms cannot be excluded.
- When used concomitantly, disulfiram inhibits the metabolism and excretion of rifampicin.
- When used simultaneously with coumarin derivative anticoagulants (including warfarin), the anticoagulant effect is enhanced and the risk of bleeding increases.
- Disulfiram inhibits liver enzymes, therefore, with simultaneous use of drugs metabolized in the liver, their metabolism may be disrupted.
- With simultaneous use of disulfiram with tricyclic antidepressants, phenothiazine derivatives, MAO inhibitors, there is a risk of developing serious adverse reactions associated with drug interactions.
- A case of the development of mania in a patient taking disulfiram and buspirone is described.
- With simultaneous use, the clearance of desipramine and imipramine from the body decreases.
- When used simultaneously with amitriptyline, it is possible to enhance the therapeutic effect of disulfiram, but it is also possible to enhance toxic effect amitriptyline on the central nervous system.
- With simultaneous use, the plasma concentration of diazepam and chlordiazepoxide increases, in some cases accompanied by dizziness. Under the influence of diazepam, the intensity of the disulfiram-ethanol reaction may decrease. A case of increased toxicity of temazepam has been described.
- When used simultaneously with phenazone, T1/2 of phenazone increases; with phenytoin - the effects of phenytoin are enhanced due to an increase in its concentration in the blood plasma, toxic reactions develop.
- When used simultaneously with chlorzoxazone, the concentration of chlorzoxazone in the blood plasma increases; with chlorpromazine - increased arterial hypotension is possible.
Reviews
We invite you to read the reviews of people who have used Teturam:
- Eugene. If you add it to food, you need to warn the person that it was given to him with food. Most people immediately stop drinking alcohol. Especially those who are already familiar with Teturam. The taste of bird cherry in the mouth instantly reminds you of the consequences of the reaction to alcohol - teturam.
- Arkady. Previously, I drank a lot and often, no admonitions helped. My wife decided to give me pills for alcoholism, I agreed because I could no longer cope on my own. I started taking Teturam, after the first dose I felt weak and didn’t crave alcohol. I drank the product for a year and a half, and I no longer fall into alcoholic binges.
Practicing narcologists believe that, in general, Teturam is effective drug for the treatment of alcohol dependence, but its use requires compliance with a number of conditions. Firstly, the consent and desire of the patient with alcoholism to take Teturam is necessary. Secondly, you need to understand the harmfulness of the disease and the desire to be cured.
In addition, doctors believe that taking Teturam alone will not help cure alcoholism forever. The pills will have an effect that will last for a certain period of time, but to prevent the person from starting to drink again, complex treatment, including psychotherapy, will be required. In other words, according to doctors, taking Teturam provides a certain “bright gap”, which, in the absence of complex treatment, will be interrupted by new breakdowns and binges. After the binge there will be new cycle taking pills, etc.
Unfortunately, Teturam may be ineffective if a person has weak willpower. In such situations, doctors recommend not taking pills, but doing a “filing” immediately.
How Teturam and alcohol interact
After prescribing Teturam tablets, doctors are asked what will happen if they are taken with alcohol and whether the medicine can be given to a drunk person.
The drug is not compatible with ethanol; treatment of alcohol dependence is based on this. A drunkard after undergoing a course of Teturam therapy cannot drink alcoholic beverages under the threat of severe poisoning.
If you add disulfiram to his food or drink secretly, when he is not warned about the consequences of drinking ethanol, then after the usual dose of drinking, the alcoholic will receive severe poisoning. You will need medical help, and it could end in death. The patient will feel sick even from 20 ml of vodka, and a dose of 100 ml of strong drink is deadly for him.
The drinker finds out that he has been mixed with a drug for a specific metallic taste. The medicine is easy to detect in the patient’s blood; it is impossible to hide the cause of poisoning either from doctors or from the alcoholic himself.
All this will significantly worsen family relationships and undermine the patient’s trust in close relatives. Persuading him to undergo treatment will be much more difficult. Moreover, then he will definitely return to regular drinking.
Important! It is impossible to forcefully cure alcoholism. Treatment without the consent of the patient is prohibited by the legislation of the Russian Federation.
If a person mixes alcohol with Teturam, he will immediately feel ill, poisoning will occur immediately. Its consequences depend on how much alcohol he drank beforehand. Ethanol together with Teturam is the most dangerous poison. 
You can start therapy with Teturam tablets only when ethanol and its breakdown products are completely eliminated from the body and the risk of their interaction is minimized. You can take the drug on the second or third day after your last drink. Sometimes the removal of alcohol from the body is accelerated by detoxifying the patient.
When can you drink alcohol?
Teturam is excreted from the body for at least two days. When taken for a long time, the drug accumulates in the patient’s adipose tissue, from where it enters the blood. When drinking alcohol, Teturam will interact with alcohol, poisoning will occur even fourteen days after the end of the course of treatment.
It happens that a certain amount of the drug remains in the patient’s blood a year after stopping it. Therefore, no matter how much time has passed since the end of therapy, you should drink alcohol with great caution. The patient can drink alcohol only after consulting with the attending physician.
The patient should not eat sweets with cognac or liqueur, sauerkraut, drink kvass, kefir, non-alcoholic beer. It is also unacceptable to take medications that contain ethanol. All of these products contain some ethyl alcohol and may cause a disulfiram reaction.
What to do in case of poisoning
When drinking alcohol together with Teturam, the patient experiences a disulfiram reaction. If the dose of alcohol is large, then the following may occur:
- cerebral edema;
- myocardial infarction;
- breathing problems;
- severe arrhythmia.
If an alcoholic who is being treated with Teturam still drinks alcohol and shows signs of acetaldehyde poisoning, he should be immediately taken to the hospital. Such poisoning is very dangerous and its consequences can only be stopped in a hospital setting. In severe cases, resuscitation measures are carried out.
Analogs
It is permissible to use analogues of the drug that have an identical active substance or have a similar effect. pharmacological effects. Analogues of the drug are presented below:
- Esperal;
- Tetlong;
- Alcodez;
- Liveria;
- Antaxon;
- Naltrex;
- Naltrexin;
- Biotredin;
- Naxon.
Before purchasing an analogue, consult your doctor.
Is it possible to give Teturam without the patient’s knowledge?
It is impossible to give Teturam to a person without his knowledge, since the drug is completely incompatible with alcohol. Accordingly, if a person secretly receiving Teturam drinks alcohol, he will develop intolerance symptoms, which, if a significant amount of alcohol is consumed (more than 150 ml of vodka), can lead to death. Therefore, it is impossible to give Teturam without the knowledge of the patient - he must know and be aware of the danger to which he exposes himself if he tries to drink while taking the medicine.
If a person drinks more than 50–80 ml of vodka while taking Teturam, he may develop severe violations work of the cardiovascular and respiratory systems, swelling and convulsions, therefore in such situations the victim is urgently hospitalized in conditions intensive care unit and carry out symptomatic therapy.
Teturam after alcohol
Teturam should not be taken the day after drinking alcohol. You must first stop intoxication (for example, by taking Medichronal) and abstain from drinking alcohol for at least 24 hours. Thus, you can start taking Teturam after drinking alcohol only for 2–3 days.
Shelf life and storage conditions
Teturam should be stored in a place well protected from children and the sun at a temperature not exceeding 25˚C. Is a prescription drug.
Shelf life – 4 years.
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Teturam – reliable and effective medicine, which is used to treat alcoholism. Usually this remedy is prescribed when other drugs do not have the desired effect. An overdose often leads to neurological complications, depression of consciousness, and coma, so it is extremely important to know how to promptly and quickly remove Teturam from the body.
General information about the drug
The medicine contains a substance called disulfiram. In addition to this active component, there are additional auxiliary components. The manufacturer produces the drug in tablets and powder.
The main effect of the drug is the blockade of acetaldehyde dehyrogenase. This component increases the content of acetaldegin and affects the biotransformation of ethanol. As a result, when a person drinks alcoholic beverages, the biotransformation of ethanol does not occur, and alcohol accumulates in the body at the level of acetaldehyde (see). Then the person’s face turns red, sometimes vomiting occurs, the heart rate increases, malaise occurs, blood pressure decreases, and a feeling of fear appears.
Taking Teturam provokes all the effects described above, as a result of which a person develops a conditioned reflex in which an aversion to alcohol occurs. It is this aversion from alcohol and the presence of side effects that is considered the therapeutic effect of the drug.
In medicine, the drug is sometimes stitched under the skin. They also take tablets and powder to dissolve in water.
Interesting!The therapeutic effect develops within four hours, but after discontinuation of the drug, the effect of the drug continues for two days.
When the tablets are implanted under the patient’s skin, the medicine begins to act immediately, and after their removal, the effect is observed for another 5–9 months. The drug is excreted in the urine.
Indications for use Teturam
This remedy is indicated for patients for the treatment of alcoholism. Taking the medicine provokes an aversion to alcohol in patients. But you can take this remedy only when other drugs do not help, since the use of Teturam often causes severe side effects.
Teturam is shown:
- for chronic drunkenness, as well as for the prevention of binges and breakdowns
- as a treatment for nickel tetracarbonyl poisoning;
The subcutaneous tablet is indicated for use in the treatment of chronic drunkenness, and also as an anti-nickel agent.
Find out which ones will help you make a correct diagnosis
Read what to do if it appears: first aid, treatment.
How is the medication taken?
The use of Teturam tablets is carried out in three stages:
- The doctor examines the patient and prescribes a dose of the drug so that the active component accumulates in the blood in a sufficiently high concentration.
- Carrying out alcohol tests. Their main principle is to drink alcohol immediately after using a high (1.5–2 times the usual) dose of the drug and causing side effects from the drug. Such tests are carried out only under the supervision of a doctor. Their main task is to form conditioned reflex by aversion to alcohol.
- After tetra-alcohol tests, low doses of the drug are continued for 3 years.
The daily dosage of Teturam is 150–500 mg 2 times. The sample period is 7–10 days. Maintenance therapy is carried out for 1–2 days in a hospital setting, 3–5 days on an outpatient basis. 1–3 years of maintenance therapy.
Overdose of Teturam
Clinical manifestations Teturam overdoses manifest themselves in the form of neurological complications and cardiovascular collapse. A depressed state is also observed. Teturam poisoning is usually divided into three forms:
- Spicy.
- Chronic.
- Alcohol turam reaction.
An acute form of drug poisoning occurs 6–12 hours after the tablet is taken. In this case, ataxia, tachycardia, the smell of acetone or sulfur from the mouth, and blepharospasm are observed. The person may fall into a coma.
The chronic stage is characterized by weakness, the appearance of dermatitis, neuropathy and appears 6–12 months after taking the medicine.
Alcoholteturam reactions occur 5–10 minutes after the patient taking Teturam drinks alcohol. In this case, the skin of the face turns red, dizziness, fear, vomiting and nausea, chest pain, and hypotension occur.
An overdose of Teturam can occur not only after drinking alcohol, but also after taking wine vinegar or alcohol-containing medications, for example, Nitroglycerin, Valocordin, and some cough elixirs.
Important! A life-threatening dose is a blood ethanol level of 50 mg or higher. This is 0.3–0.6 g/kg of human weight. An overdose in this case develops immediately, within 5–10 minutes after drinking alcohol. The reaction lasts approximately 2–3 hours. If measures were taken on time, a favorable outcome occurs within 4 hours.
The clinical picture of severe drug poisoning is characterized by headaches, nausea and repeated vomiting. The person does not realize what is happening to him, his blood pressure drops sharply, and loss of consciousness occurs.
In order to provide timely and correct assistance to the patient, he needs to know and tell the doctor that he is taking Teturam. Unfortunately, sometimes there are situations when the patient does not know that he is “on pills,” while relatives secretly slip drugs into his food. In such situations, it is extremely difficult to diagnose the cause of all the symptoms described above. Confirmation that poisoning occurred while taking Teturam is a blood test for ethanol.
How to remove Teturam from the body
There is no antidote to quickly remove the substance from the body. That's why doctors start symptomatic treatment, which helps reduce the severity of drug overdose:
- Coma patients are intubated. If they experience hypotension, use infusion therapy and administration of Norepinephrine.
- At the second stage of treatment, Pyridoxine is used in a dose of up to 1 g. If vomiting occurs, it is eliminated using Reglan or Ondansetron. Hyperthermia treated with use of NSAIDs(non-steroidal anti-inflammatory drugs).
- At the third stage, high doses of vitamin C up to 1 g are used. The substance is administered as an effective antioxidant. Also recommended is the use of Unithiol 0.3 ml/kg body weight, sorbents, and saline laxatives. Sorbents are used twice, since Teturam participates in enterohepatic circulation, as a result of which it is released into the intestine and reabsorbed from it.
In rare cases, blood transfusions or hemodialysis are resorted to.
Find out why it appears: causes and treatment.
Read why and how to fix the problem.
Do you know that - defense mechanism? Find out how to help the victim.
Summarizing
Unfortunately, it is impossible to quickly remove the drug from the body; the effect will be observed for another two weeks after stopping the medication. The fact is that the active component accumulates in the subcutaneous fat layer, from there it enters the blood in small doses. Due to this, the concentration of the component in the blood is constantly maintained and is eliminated only two weeks after the drug is completely discontinued.
Tablets for alcoholism "Teturam" are a drug based on disulfiram of provocative action, that is, it causes unpleasant symptoms that predispose to the development of an aversion to alcoholic beverages. Narcologists say that the effectiveness of such therapy reaches 75%. However, the treatment regimen and method of taking the medicine - oral or “sewn” capsules under the skin - are selected individually.
"Teturam" is available only in the form of white flat-cylindrical tablets. For stitching, dosages of 100 mg are usually used, while for oral therapy, tablets of 150 and 250 mg are used. The active substance is disulfiram. It inhibits the activity of enzymes responsible for the breakdown of ethanol. As a result, the process of removing residual decay products and other toxins slows down. The body begins to perceive alcohol as a poison, against the background of which an aversion to alcohol develops.
Teturam and alcohol are incompatible things. If alcohol is consumed during treatment, the patient will experience severe clinical picture. The main symptoms will be stomach pain, intestinal disorder, nausea, vomiting and headache.
The bioavailability of the active substance is 70–90%. Once in the bloodstream, it accumulates in fatty tissues, from where it then begins to be gradually released. The total metabolic cycle takes 48 hours, although the first Clinical signs can be noticed 3 hours after taking the tablet. Severe symptoms and a tendency to reject alcohol begin after three days of use.
It is interesting that Teturam is excreted not only during urination and defecation, but also partially during exhalation.
How to use?
The instructions for use of Teturam describe in detail all the features of the administration. The recommended dosages are indicated there, but this information is presented more for informational purposes. Disulfiram is a powerful substance that can cause severe side effects, so the possibility of treatment, dosage and course duration are determined by the attending physician on an individual basis.
Treatment begins only after the following measures have been completed:
- in-depth examination to ensure there are no contraindications;
- a course of detoxification therapy and complete elimination of withdrawal symptoms;
- discontinuation of antipsychotics, antidepressants and sleeping pills 3 days before the start of therapy;
- determination of the level of liver transaminases.
During therapy, the patient must be constantly monitored general indicators: condition, pulse, arterial pressure etc., as well as donate blood for screening laboratory parameters.
Under no circumstances should you give Teturam tablets to a patient without his knowledge. If a person unknowingly continues to drink alcohol, this can lead to severe intoxication and even death. When drinking 50–80 g of vodka, cardiac and respiratory failure, and after 150 mg - death.
Contraindications
Disulfiram is considered basic drug in the treatment of alcoholism because it is cheap and effective. However, such therapy is not available to all patients due to a wide list of absolute contraindications:
- diseases of the digestive system: erosive lesions, acute phase ulcers or gastritis, bleeding, liver and kidney failure;
- oncological processes;
- CNS diseases: mental disorders, epilepsy, infectious processes(meningitis, encephalitis);
- polyneuritis of any origin;
- convulsive syndromes;
- disruption of the production of thyroid hormones;
- diabetes;
- diseases of the spleen and bone marrow;
- diseases of the respiratory system: asthma, emphysema, tuberculosis;
- severe diseases of the cardiovascular system;
- individual hypersensitivity to the active substance;
- early age;
- pregnancy and lactation.
With liver cirrhosis, the concentration of Teturam in the bloodstream increases, so clinical symptoms appear more pronounced than with liver failure mild to moderate.
Concerning relative contraindications, in which the use of Teturam for alcoholism is permitted, but only with caution and in a hospital setting, then these syndromes should include:
- old age (over 60 years);
- chronic heart and digestive diseases in remission phase;
- endarteritis;
- a history of strokes, central nervous system infections and psychoses that developed against the background.
Cross reactions
In addition to contraindications, Teturam has wide list drugs, the parallel use of which causes unpleasant drug interactions. Therefore, it is very important that the therapy is conducted by a qualified narcologist.
| "Teturam" + | Consequences |
|---|---|
| "Phenytoin" |
|
| "Imidazole" | development of delirium up to delirium tremens and alcoholic psychosis |
| "Isoniazid" |
|
| Anticoagulants (indirect) | the therapeutic effect of anticoagulants increases, which can lead to internal bleeding |
| "Chlorpromazine" | increased risk of developing hypotension |
| "Theophylline" | increased concentration of “Theophylline” with the risk of overdose |
| Benzodiazepines |
|
| Antidepressants (tricyclics) | strengthening of the body's aggressive reaction to alcohol-containing drinks caused by Teturam |
The table shows the main drugs. More full list presented in the instructions for use. Medicines containing appropriate active substances, can also cause undesirable consequences. If combined therapy is necessary, these drugs are still given to the patient, but only in a hospital setting, since constant monitoring of his condition is necessary.
Standard treatment regimen
The three-stage therapeutic regimen is a classic method of treating drunkards and patients admitted to drug addiction treatment due to severe intoxication. It cannot be called easy and comfortable, since during the treatment the patient experiences psychological discomfort and a severe clinical picture. An aversion to alcohol is instilled in three stages.
- During the first period (7–10 days), the patient is shown oral administration 250–500 mg of the drug per day, depending on the patient’s condition and medical history. The tablets are divided into 2 doses, usually morning and evening. They are recommended to be taken with meals. At this stage, it is pointless to prescribe less than 150 mg, since it is necessary to achieve the accumulation of a high concentration of disulfiram in the bloodstream. And small doses will be quickly processed and disposed of.
- The duration of the second treatment period is determined individually. It involves conducting provocative tests, when the patient is simultaneously prescribed Teturam and alcohol. After consuming a high dose of the drug, which is usually twice the amount prescribed in the first stage, the patient is given 20–30 g of vodka to drink. After this, within half an hour the patient begins an acute response of the body with characteristic symptoms: intoxication, headaches, nausea and vomiting. If this clinical picture stops after 20 minutes, then the test performed is considered weak and ineffective. Therefore, next time the amount of alcohol is increased by 10–20 g. The interval between samples is 1–2 days in a hospital setting and 3–5 days if treatment is carried out on an outpatient basis. Total samples are determined individually. the main objective This stage is to achieve in the patient a persistent feeling of rejection of alcohol.
- The third period is necessary to consolidate the achieved effect. It can last up to 36 months when the daily dose of the drug does not exceed 150 mg.
Due to the accumulation of disulfiram in adipose tissue, the therapeutic effect continues after discontinuation of the drug for about two weeks.
The “correct” reaction during a teturam alcohol test is manifested by the following symptoms:
- severe redness of the face and local or systemic hyperthermia;
- nausea and vomiting;
- general malaise;
- hypotension.
Acute reaction to teturam alcohol test
At the second stage of treatment, the development of acute alcohol poisoning due to the toxic effects of disulfiram. This is manifested by depressed breathing, convulsive syndrome and severe throbbing headache with a feeling of fullness. Poisoning is also indicated by a prolonged “correct” reaction, which lasts longer than 90 minutes. Depending on the symptoms that appear, treatment is prescribed.
Mandatory measures
- 15 ml methylene blue (1%) intravenously;
- “Camphor” and “Cordiamin” subcutaneously;
- “Strychnine”, “Ephedrine”, “Cititon” intramuscularly;
- oxygen inhalation;
- ascorbic acid solution with glucose intravenously
Additional measures for symptomatic indications:
| Symptoms | Cupping |
|---|---|
| heart pain | "Validol", "Corvalol", "Nitroglycerin" |
| blood pressure below 70/50 | "Mezaton" intravenously |
| worsening heart rhythm | dropper with "Strophanthin" |
| convulsions |
|
| vomiting and severe nausea |
|
| overexcitement | 1 ml "Aminazin" (2.5%) intramuscularly |
Short treatment regimen
Narcologists note that for patients who have consciously decided to quit drinking, therapy is much easier and more comfortable, and its effect is longer lasting, since there is a clear psychological message. For such patients, a three-week treatment regimen is recommended, involving only oral medication. The therapy goes like this:
It has long been proven that in 3 weeks you can develop a habit and get rid of it. Although alcohol addiction- this is a more complex biochemical attraction, but with a strong desire and through medications, you can develop a tendency towards a healthy lifestyle. However, if a craving for alcohol appears or in case of relapse, a repeated therapeutic course of disulfiram is indicated.
Sew-in method
“Hedging,” or as people say “coding,” is a procedure in which the patient is made a small incision in the skin, 8 100 mg tablets are placed under the epidermis, and then sutured. In a couple of days, the tablets dissolve, and the active substance is deposited in lipid tissues, from where it is released for at least six months. At this time, the patient feels all the unpleasant symptoms of drinking alcohol.
This treatment regimen is much more popular, since there is no need to take pills for a long time and, moreover, to carry out painful alcohol tests. Its therapeutic effect is longer, although after about 9 months disulfiram is completely removed from the body. If during this time a psychological aversion to alcohol has not developed, then there is a risk of relapse, just as after oral therapy.
Teturam “stitching” can cause polyneuropathy, so the “coded” patient is prescribed a mandatory course of B vitamins. If this complication If it develops anyway, it is necessary to remove the tablets.
Consequences of taking
Treatment of alcoholism requires the use of quite powerful and toxic drugs, which is disulfiram. Therefore, in the process of taking the drug "Teturam" can cause various side effects and undesirable consequences. Conventionally, they can be divided into three groups:
| Adverse reactions caused by | ||
|---|---|---|
| properties of the drug | simultaneous intake of alcohol | long-term use of the drug |
|
|
|
If urine darkens, jaundice develops, severe asthenia or anorexia, it is necessary to urgently stop taking the medication and begin a high-quality liver cleansing. Due to the high hepatotoxicity of disulfiram, there are cases where such treatment led to the need for liver transplantation or death. The development of paresthesia, manifested by stabbing sensations in the legs, indicates the development of an acute reaction, in which it is necessary to urgently stop treatment with Teturam.
The simultaneous use of disulfiram with alcohol is very dangerous and causes weight loss. unpleasant symptoms. Therefore, it is necessary to completely avoid the use of products containing ethanol. This includes not only alcoholic beverages, but also certain foods, other medications (usually syrups, tinctures, and oral solutions), and even cosmetics such as aftershave gel and mouthwash.
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