Interferon human leukocyte dry - a group of proteins synthesized by leukocytes donated blood in response to the influence of an interferon inducer virus. Antibodies to the HIV-1 virus, HIV-2 virus, hepatitis C virus and hepatitis B virus surface antigen are absent.
Active ingredient: interferon alpha
Activity: not less than 1000 ME per ampoule.
Auxiliary components:
Sodium chloride - 0.09 mg;
Sodium dihydrogen phosphate dihydrate - 0.06 mg;
Sodium hydrogen phosphate dodecahydrate - 0.003 mg;
Sucrose - 0.03 mg.
Description:A porous amorphous mass or powder of white or light yellow to bright red color. Hygroscopic.
The reconstituted drug is a clear liquid from light yellow to bright red.
Pharmacotherapeutic group: MIBP - cytokine ATX:L.03.A.B.01 Interferon alpha
Pharmacodynamics:Interferon alpha has the following effects:
Antiviral (flu, herpes, adeno viral infections and etc.);
Antibacterial (bacteriostatic) against mixed infections;
Immunomodulatory (normalizes immune status);
Immunostimulating (strengthens the immune response);
Anti-inflammatory.
Interferon alpha from normal human leukocytes has an indirect antiviral effect, which consists in creating defense mechanisms in cells not infected with the virus: changes in the properties of cell membranes that prevent the virus from penetrating into the cell; initiation of the synthesis of a number of Specific enzymes that prevent the replication of viral RNA and the synthesis of viral proteins.
Pharmacokinetics:The main properties of interferon alpha are used with therapeutic purpose. inhibits the replication and transcription of viruses and chlamydia. Has an antiviral effect, inducing a state of resistance to viral infections in cells and modulating the response immune system, aimed at neutralizing viruses or destroying cells infected by them. The mechanism of antiviral action is to create protective mechanisms in cells not infected with the virus. By binding to specific receptors on the cell surface, it changes the properties of the cell membrane, prevents adhesion and penetration of the virus into the cell, stimulates specific enzymes, affects RNA and inhibits the synthesis of viral proteins. Suppresses viral replication in an infected cell. The listed properties of interferon alpha allow it to effectively participate in the processes of pathogen elimination, prevention of infection and possible complications. Thanks to the immunomodulatory activity of interferon alpha, the immune status is normalized. The immunomodulatory effect is due to stimulation of the activity of macrophages (phagocytic activity) and natural killer cells (NK cells). Stimulates the process of antigen presentation by macrophages immunocompetent cells. Under the influence of interferon alpha in the body, the activity of T-helpers, cytotoxic T-lymphocytes, the expression of MHC type I and II antigens, as well as the intensity of differentiation of B-lymphocytes increases. Activation of leukocytes ensures their active participation in the elimination of primary pathological foci and ensures the restoration of production secretory immunoglobulin A.
Indications: Prevention and treatment of influenza and other acute respiratory viral infections. Contraindications:Use with caution in persons with hypersensitivity to antibiotics and hypersensitivity to drugs of protein origin, including chicken meat and chicken eggs. Carefully:Persons with allergic diseases in the anamnesis.
The drug can be used by children and adults with chronic diseases.
Pregnancy and lactation:During pregnancy and lactation, Interferon is prescribed only if the expected effect for the mother exceeds the risk for the fetus. Directions for use and dosage:Open the ampoule with the drug immediately before using it and add sterile distilled or cooled boiled water in a volume of 2.0 ml, that is, up to the color line marked on the ampoule. Dissolution time should not exceed 3 minutes. The dissolved drug should be clear liquid, having shades from light yellow to bright red.
The drug solution can be stored at temperatures from 2 °C to 8 °C for no more than one day.
For prevention and treatment, the same dosage regimen is used for children and adults. There is no age limit for children.
Use for prevention:
For the purpose of prevention, administration of the drug should begin when there is an immediate threat of infection and continue as long as the risk of infection remains. To prevent influenza and other acute respiratory viral infections, use the dissolved drug intranasally.
Spraying the drug solution can be done using sprayers of any system. 0.25 ml of solution should be administered into each nasal passage 2 times a day, with an interval of at least 6 hours.
When instilling the drug solution, administer 5 drops (0.25 ml) into each nasal passage 2 times a day with an interval of at least 6 hours.
Use in treatment:
For treatment purposes, the drug should be used at an early stage of the disease when the first clinical symptoms appear.
When treating the drug, use it inhalation and intranasally. Most in an efficient way is inhalation. To carry it out, inhalers equipped with electric heating or another system are recommended. For one administration, use the contents of 3 ampoules of the drug, which are dissolved in 10 ml of sterile distilled or boiled water. Heat the solution to a temperature not higher than 37 °C. The drug is administered by inhalation 2 times a day with an interval of at least 6 hours.
Spraying the drug solution can be done using sprayers of any system. 0.25 ml of solution should be injected into each nasal passage after 1-2 hours, at least 5 times a day for 2-3 days.
When instilling the drug solution, administer 5 drops (0.25 ml) into each nasal passage after 1-2 hours, at least 5 times a day for 2-3 days.
Precautions for use:
Administration by injection is strictly prohibited.
The drug is unsuitable for use if:
- the seal of the packaging is broken;
- markings are missing or difficult to read;
- expiration date has expired.
Side effects:Registered side effects not found. With long-term use, no sensitization was detected. Allergic reactions (urticaria, polymorphic rash) may develop in people who have hypersensitivity to antibiotics and hypersensitivity to drugs of protein origin, including chicken meat and chicken eggs. Overdose: No cases of overdose have been identified. Interaction:In tissue culture experiments carried out in the antibiotic laboratory, it was found that when joint use methyluracil with dry human leukocyte interferon, a pronounced synergistic effect is observed. A pronounced synergistic effect is observed when human leukocyte interferon is combined with lysozyme.
Composition and release form of the drug
1000 IU - ampoules (5) - cardboard packs.
1000 IU - ampoules (10) - cardboard packs.
pharmachologic effect
Interferon alpha is a mixture of different subtypes of natural alpha interferon from human blood leukocytes. It has an immunostimulating and antiproliferative effect. Antiviral effect The drug is based mainly on increasing the resistance of body cells that have not yet been infected with the virus to possible effects. By binding to specific receptors on the cell surface, interferon alpha changes the properties of the cell membrane, stimulates specific enzymes, affects the RNA of the virus and prevents its replication. The immunomodulatory effect of interferon alpha is associated with stimulating the activity of macrophages and NK (Natural killer) cells, which, in turn, participate in the body’s immune response to tumor cells.
Indications
For parenteral use: hepatitis B and C, genital warts, hairy cell leukemia, multiple myeloma, non-Hodgkin's lymphoma, mycosis fungoides, Kaposi's sarcoma in patients with AIDS without a history acute infections; renal carcinoma; malignant melanoma.
For rectal use: treatment of acute and chronic viral hepatitis.
For intranasal use: prevention and treatment of influenza, ARVI.
Contraindications
Severe organic heart disease, severe dysfunction of the liver or kidneys; epilepsy and/or dysfunction of the central nervous system; chronic hepatitis and liver cirrhosis with symptoms liver failure; chronic hepatitis in patients receiving or recently receiving treatment (except for treatment with corticosteroids); autoimmune hepatitis; diseases thyroid gland resistant to traditional therapy; confirmed increased sensitivity to interferon alpha.
Dosage
The dose, frequency and duration of use are determined depending on the indications, severity of the disease, route of administration, and individual patient response.
Side effects
When used parenterally, side effects are observed much more often than with other routes of administration.
Flu-like symptoms: fever, myalgia, weakness.
From the outside digestive system: loss of appetite, nausea, vomiting, diarrhea; rarely - liver dysfunction.
From the outside of cardio-vascular system: arterial hypotension, arrhythmia.
From the side of the central nervous system: drowsiness, impaired consciousness, ataxia.
Dermatological reactions: rarely - slight alopecia, dry skin, erythema,.
Others: general weakness, granulocytopenia.
Drug interactions
Since interferons inhibit oxidative metabolism in the liver, the biotransformation of drugs metabolized by this route may be impaired.
When used simultaneously with ACE inhibitors Possible synergism in relation to hematoma toxic effect; c - synergism regarding myelotoxic action; with paracetamol - it is possible to increase the activity of liver enzymes; with theophylline - decreased clearance of theophylline.
special instructions
Use with caution in patients with a history of a recent myocardial infarction, as well as in cases of changes in blood clotting and myelodepression.
For thrombocytopenia with a platelet count of less than 50,000/μl, s.c. should be used.
Patients should receive hydration therapy, especially during the initial period of treatment.
In patients with hepatitis C receiving interferon alfa therapy for systemic use, possible dysfunction of the thyroid gland, expressed in hypo- or hyperthyroidism. Therefore, before starting a course of treatment, you should determine TSH level in the blood serum and begin treatment only if the TSH level in the blood is normal.
Use interferon alfa with caution concomitantly with hypnotics. sedatives, opioid
Contraindicated in pronounced violations liver functions, chronic hepatitis and liver cirrhosis with symptoms of liver failure; chronic hepatitis in patients receiving or recently receiving treatment with immunosuppressants (except for treatment with corticosteroids); autoimmune hepatitis.
Use in old age
If side effects from the central nervous system develop in elderly patients receiving interferon alfa in high doses, it should be carried out thorough examination and, if necessary, interrupt treatment.
Latin name: Interferon alfa
ATX code: L03AB01
Active substance: Interferon alpha
Manufacturer: Biomed, Russia
Conditions for dispensing from a pharmacy: Over the counter
Human leukocyte interferon in liquid form, it is produced from components of donor blood and is used for the treatment and prevention of acute respiratory viral infections and influenza, and helps strengthen the immune system.
Indications for use
Compound
In one milliliter medicinal solution contains interferon alpha, mass fraction which is 1 thousand ME. Additional components speakers:
- Purified water
- Sodium chloride and hydrogen phosphate dodecahydrate
- Sodium dihydrogen phosphate dihydrate.
Medicinal properties
Interferon alpha exhibits antiviral activity, has antibacterial effect, normalizes the reduced immune status, and also activates the functioning of the immune system. Along with this, it exhibits its anti-inflammatory effect.
Human leukocyte interferon liquid is characterized by an indirect antiviral effect; it promotes the formation of specific protective mechanisms in infected cells: it changes some properties of the cell membrane; thermositizes the disappearance of the virus into the cellular structure; promotes the production of special enzymes that prevent the synthesis of pathogenic RNA on the RNA matrix and the production of proteins of a particular virus.
Due to the immunomodulatory effect of interferon alpha, the functioning of the immune system is restored. This effect on the body is caused by a special effect on macrophages, as well as natural killer cells.
Under the influence of alpha interferon, the activity of the so-called T-helpers, as well as T-lymphocytes (cytotoxic type), increases. Thanks to the activation of leukocytes, their active participation in the process of eliminating pathological foci is observed, and the production of secretory IgA is restored.
The solution is sterile, has no toxic effect on the human body, and can be used for inhalation procedures.
Release form
Interferon leukocyte human liquid is presented in a homogeneous colorless liquid pale pink shade. The drug is available in a 5 ml bottle. The package contains 1 fl. Interferon drug.
Alpha interferon liquid: instructions for use
Price: from 118 to 131 rubles.
To prevent the development of ARVI and influenza, inhalation procedures with a medicinal solution are prescribed; human interferon can also be used intranasally. This form interferon alpha is not used for injection.
The bottle of solution must be opened immediately before use. Nebulization of the medicine can be carried out by any nebulizing devices.
For prevention, it is recommended to administer the solution intranasally, 5 drops. into each nasal passage twice in 24 hours, while the dosage for children and adult patients is the same. The time interval between instillations should be observed - 6 hours.
When treating influenza and ARVI, inhalation procedures are prescribed; for this purpose it is better to use electrically heated inhalers or other types of devices.
For one procedure, you will need to take 3 bottles of the drug Interferon with a volume of 5 ml, then dilute the contents with 4 ml of purified water. After this, the mixture is heated to 37 C. Antiviral inhalations should be carried out twice a day with a minimum interval of 6 hours.
Intranasal use with therapeutic purpose– instill 5 drops, maintaining a time interval of 1-2 hours (frequency of use – at least 5 rubles). The duration of treatment is 2-3 days.
Use during pregnancy and pregnancy
The use of a drug in this group of patients is advisable only when the expected benefit to the mother’s body significantly exceeds probable risks for a child.
Contraindications
There are no contraindications for intranasal use. Treatment should be carried out with caution in cases of excessive susceptibility to antibacterial agents, drugs of protein nature. During treatment may develop allergic reactions Therefore, allergy sufferers should use the drug with extreme caution.
The drug is not prescribed for:
- Serious diseases of the cardiovascular system
- Irregularities renal system and kidneys, central nervous system and hematopoietic system
- Hepatitis occurring in chronic form, against the background of liver cirrhosis (decompensated)
- Chronic hepatitis before or after receiving treatment with immunosuppressants.
Precautionary measures
Pereral administration of this product is not permitted. medicine. The most effective treatment will be using heated inhalers.
Cross-drug interactions
During numerous laboratory research the following was revealed: the simultaneous use of methyluracil promotes the manifestation of a pronounced synergistic effect. The same reaction is possible when combined use interferon with lysocine.
Side effects
During interferon therapy, the following reactions are possible:
- Feverish state
- Lethargy and drowsiness
- Loss of appetite
- Pain in muscles and joints
- Feeling of dryness in the mouth
- Excessive sweating
- Nausea and vomiting
- Impaired taste perception
- Epigastric pain
- Weight loss
- Deterioration of the functioning of the gastrointestinal tract
- Development of liver pathologies, including hepatitis
- Severe dizziness accompanied by headache
- Excessive nervous excitement
- Deterioration in sleep quality
- Decreased visual acuity
- Development of ischemic retinopathy
- Depressive state
- Allergic manifestations on the skin.
Storage conditions and shelf life
The drug Interferon leukocyte human liquid must be stored in its original packaging in compliance with strict temperature regime(2-8 C), it is good for 2 years.
An opened bottle of medicine can be stored at a temperature of 2 - 8 C for three days.
Analogues
Feron, Russia
Price from 55 to 1067 rub.
Viferon is a drug based on Interferonum alpha-2b. Used to treat infectious and inflammatory diseases, including viral hepatitis, both in children and adults. It is produced in the form of ointment, suppositories and gel.
Pros:
- Several dosage forms
- Has an immunomodulatory effect
- Can be prescribed to infants.
Minuses:
- Not prescribed if you are sensitive to interferon alfa
- Must be stored at low temperature (2-8 C)
- During treatment it may provoke allergic reactions.
IN modern world people are susceptible to many diseases. Especially often a person gets sick with a cold or flu. They can be easily and effectively treated with specialized drops.
However, in more severe diseases such as warty formations on the skin malignant diseases blood, herpes diseases in AIDS patients require really serious drug treatment.
One of the effective medicine, designed to combat various kinds of viruses and strengthen the immune system - “Interferon”. The drug has a wide spectrum of effects, which allows it to be used both for the prevention of diseases and for the treatment of a wide range of diseases.
"Interferon" dry in ampoules was first released in 1957. Then the professors found out that this medicine eliminates foci of the virus and prevents influenza infections from multiplying.
Today, dry Interferon is sold in white or yellow ampoules. IN compound medicines included leukocytes from donor blood, presented as a mixture of proteins.
Using the drug, the body instantly absorbs the necessary elements. After this, the elimination of viruses begins.
Among side effects note:
- skin diseases;
- nausea;
- headache;
- shiver.
Among contraindications note:
- individual intolerance;
- disruption of the functioning of the human immune system;
- the product may begin to be perceived as the body’s own tissues;
- acute form coronary disease hearts;
- partial loss of kidney function.
If you take the medicine for a long time, monitor your blood composition and liver function.
In what cases is it possible to use Interferon?
For prevention:
- flu and colds;
- chronic hepatitis C;
- chronic hepatitis B;
- with a viral infection in which a person is affected by fever and intoxication;
- oncopathologies, including in patients with AIDS.
At the following diseases medicine should be used during treatment:
- wart-like formations on the mucous membranes and skin in the genital area;
- plasma cell cancer;
- for skin cancer diseases;
- Kaposi's sarcoma (in patients with AIDS);
- leukemia with white blood cells with hair-like growths;
- defeat bone marrow person;
- tumors in the kidneys and bladder;
- the formation of multiple papillomas on the mucous membrane of the larynx;
- a significant increase in platelets in the blood;
- malignant tumor of reticular tissue.
It is worth noting that Interferon should start using at the first appearance of a threat of disease. Thus, you will more effectively destroy the source of inflammation and recover faster.
"Interferon" dry - instructions for use
Interferon is usually prescribed at the most early stages diseases. If you notice the first symptoms of a cold or flu, purchase this medicine.
The dosage of the drug for children and adults is identical.
It should be used by instillation into the nose using inhalation or spraying. When spraying, inject 0.25 ml solution.
Open the ampoule a second before use!
For instillation into the nostrils you need to add purified water up to the symbol in 2 ml to the powder in the ampoule.
Apply the medicine six drops into each nostril. It is worth knowing that the interval between use should be approx. seven o'clock.
The duration of the course should not be more than five days.
The use of the medication is prohibited for thyroid diseases. If you have liver or kidney dysfunction, using this medicine is dangerous to your health.
The use of the medicine for children under two years of age is permitted only after consultation with a doctor.
Conclusion
In the cold season, a person is susceptible to colds much more often than in summer. According to experts, best treatment diseases is maintaining immunity throughout the year.
In cases of a weakened immune system and for prevention, use Interferon. It will protect you from viruses and various infections as a barrier.
Use the drug only with the permission of your doctor. Keep an eye on the expiration date of the medication.
Do not use the medicine if the seal of the package is broken.
Effective therapeutic and prophylactic– interferon. The spectrum of its action is very wide, production is established both abroad and in our country, the price range is accessible to everyone.
Indications for use
The product has primarily antiviral and immunoforming properties, and also has an antiproliferative (stopping tissue growth) effect.
Application for various diseases has long been tested and the results have been recorded, the drug is approved in Russia for the treatment of the following diseases and conditions:
- respiratory viral infections, incl. and pneumonia and their prevention;
- hepatitis B, C, D(delta);
- herpes and herpes zoster;
- some malignant diseases;
- papillomas;
- certain fungal diseases;
- conditions after chemotherapy and radiation exposure;
- decreased immunity of various origins.
Directions for use and doses
Human leukocyte interferon is available in several forms and is used in various ways.
- Suppositories are used rectally once a day to prevent ARVI in children for a month. For treatment respiratory diseases used 2 times a day, in courses of 5 - 10 days, dose from 250,000 IU active substance. In this case, it is necessary to observe the administration interval - no more than 12 hours. In doses of 500,000 IU, they are also used in adults 2 times a day.
- Suppositories are used vaginally for viral diseases genitourinary area twice a day, in a dose of up to 1,000,000 IU, determined by a doctor, for 10 days - the substance has local impact and penetrates the bloodstream. When alternating with other medications, use 1 time per day. The doctor may also recommend a maintenance dose once every 1 to 3 days for 10 to 30 days.
- Interferon is available for injection and must be administered subcutaneously, intradermally, intramuscularly or intravenously. It is sold strictly according to prescription. Be careful, human leukocyte interferon,intended for nasal irrigation, it is strictly prohibited to administer by injection.
- Dry powder is intended for dilution with distilled or boiled water and is used for irrigation of mucous membranes. After opening, the ampoule or bottle is stored for a maximum of 24 hours. Place 5 drops in the nostril twice a day.
- Nasal and eye drops- ready-to-use solutions used topically for direct application or as inhalation through a nebulizer.
- Interferon-based ointments are applied to areas of infection on the skin, for example, for herpes rashes, at least 2 times a day.
The exact dosage of the drug is prescribed exclusively by the doctor, who, if necessary, adjusts the method and frequency of use.
Self-prescription and use of the drug is unacceptable!
Contraindications
Interferon affects the functioning of the entire body, so in some cases unwanted side effects may occur. To prevent them, you should strictly follow your doctor’s instructions and not exceed the dose.
Contraindications for use are:
- decreased kidney function;
- cirrhosis of the liver;
- serious illnesses hearts;
- epilepsy;
- depression and psychosis;
- changes in thyroid function that are resistant to therapy;
- individual hypersensitivity.
Special Terms of Use
Interferon is not prescribed to pregnant women unless it is strictly necessary. If used during lactation, breastfeeding should be discontinued. Resumption of breastfeeding is possible within a day after the end of the course of treatment.
If the temperature rises while using interferon, you should take an antipyretic - the protein is alive at a temperature not higher than 37°C.
Interferon is not used when using antidepressants (increased effects).
Use the medicine with caution when working with machinery and driving vehicles.
Overdose
There were no cases of toxic effects of increased doses of the drug. In case of accidental intake large quantity substances, measures must be taken to remove them.
Side effects
The adverse effect can manifest itself in various problems.
- cardiological: arrhythmia, tachycardia and bradycardia;
- vascular: significant decrease blood pressure;
- digestive: loss of appetite, nausea, vomiting, diarrhea;
- nervous system: instability of consciousness, sleep disturbances;
- somatic: headaches, chills;
- mental: depression, decreased mood;
- skin: rash, itching skin, swelling
Composition and pharmacokinetics
In its pure form, interferon is contained in powdered ampoules - for dilution and irrigation or injection.
Suppositories, suppositories and ointments contain, in addition to interferon, a fatty base that gives a thick or hard consistency.
Interferons are produced from proteins of mammals, including humans, that have been exposed to the virus. Human leukocyte interferon is the most acceptable in composition; it absolutely excludes the content of pathogenic agents (including HIV and hepatitis).
The mechanism of action is to create a protective barrier of healthy cells around the site of infection, the permeability of which to the virus is insurmountable due to the influence of interferon. This prevents growth tumor formations– cells become unable to divide.
The action begins, depending on the method of administration, after 0.5 – 2 hours and lasts at least 6 hours, more often 12. The substance is completely and without a trace eliminated from the body within 24 hours from the last dose.
Storage and guarantees
The drug is stored in a dark and cool place. There is information that stored at room temperature the drug causes more side effects. Strictly unacceptable heat storage (above 37°C).
The shelf life of all drugs containing interferon is 2 years from the date of release. The opened drug (ampoule) and the prepared solution must be used within 3 days.
Human leukocyte interferon is available from pharmacies without a prescription.
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