Contraindications and side effects of Riboxin. Affordable and effective drug Riboxin: instructions for use Riboxin what is it for

Riboxin helps increase the energy reserves of the myocardium, accelerate metabolic processes and improve coronary blood flow. Prescribed for ischemia and dystrophy of the heart muscle, rhythm disturbances. Contraindicated for gout. Most patients report good tolerability of the drug.

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Composition of the drug Riboxin

The main active ingredient is inosine. It is considered the precursor of ATP, the main energy source of all biological processes in the body. Inosine has the following properties:

• accelerates muscle growth and strength (anabolic effect);
• increases metabolic activity in the myocardium;
• stimulates the formation of nucleic acids;
• prevents cell destruction under conditions of nutritional deficiency;
• improves coronary circulation;
• reduces the size of the necrosis zone during a heart attack;
• takes part in glucose metabolism;
• restores abnormal heart rhythm;
• increases myocardial contractility;
• helps deeper relaxation of the muscle fibers of the heart during diastole;
• prevents platelet aggregation (sticking together);
• promotes regeneration of heart tissue.

Indications for use

Riboxin has been well studied, its use has proven effectiveness in the following diseases:

• dystrophy of the heart muscle after physical overexertion, infections or hormonal imbalances;
• defects of heart structure and origin;
• liver diseases, including after taking medications;
• to enhance immunity during radiation therapy.

Riboxin can also be used to improve exercise tolerance after long-term illnesses, and is taken by athletes to increase endurance and muscle growth.

Mode of application

As a rule, at the beginning of treatment, 1 tablet of Riboxin 200 mg is prescribed 3 or 4 times a day. If the drug is well tolerated, then the daily dose can be gradually increased to 2.4 g, which corresponds to 12 tablets. Add no more than 3 tablets per day, the intervals between dose adjustments should be at least 3 - 5 days.

Riboxin in ampoules is used for intravenous administration. In case of an attack of rhythm disturbance, a jet injection of 10 - 20 ml of solution can be used. For droppers, 10 ml per day is prescribed in a solution of glucose 5% or sodium chloride 0.9%, the rate of administration should not exceed 50 drops per minute. In the future, it is possible to double this dose. Typically the patient receives 10 or 15 infusions.

Combination with other drugs

Positive interaction and increased effect of the drugs were noted when combined with cardiac glycosides. Riboxin can prevent complications such as rhythm disturbances when treated with these drugs. It also increases the effect of Heparin, anabolic and non-steroidal anabolics.

For ischemic disease, Riboxin can be included in the composition complex treatment together with beta blockers, nitrates, calcium antagonists and diuretics (thiazides and potassium-sparing).

A negative combined effect occurs with drugs for the treatment of renal failure, Euphyllin, Caffeine, vitamin B6, and alcohol.

Side effects of cardiac medication

Most patients tolerate Riboxin treatment well. Long-term experience of use proves its effectiveness and safety when prescribed to older people. In rare cases, the following unwanted reactions are possible:

The drug ATP is prescribed for patients with myocardial ischemia, hypertension, and also for the treatment of cardiac arrhythmias. It is used in ATP ampoules, and in ATP-Long tablets. What other drugs are there that contain the main component?

If there are prerequisites, then only drugs for the prevention of stroke will help avoid disaster. Primary and secondary prevention in men and women includes medications for the treatment of precursor diseases, pills, including those for bad habits, as well as drug therapy from recurrent hemorrhagic stroke. What is the program of individualized secondary prevention? For what needed Glycine, Aspirin, statins after stroke. What does the school of prevention prepare for? How to avoid a stroke at the first sign, what to take. What absolutely cannot be done.

Non-glycoside cardiotonics are used to recover from shock and to resume heart function. Since synthetic drugs have a rather strong effect on the body, they are used in a hospital setting. There is a certain classification of cardiotonics.

If a diagnosis of angina pectoris has been established, treatment will first be directed to the root cause of the problem, for example, ischemic heart disease. Drug treatment stable angina takes place in the hospital.

"Riboxin" is a drug that can have a positive effect on the energy supply of body tissues and metabolism.

It normalizes heart rate and coronary circulation, and also increases the energy balance of the myocardium. By participating in glucose metabolism, Riboxin stimulates metabolic processes in the absence of ATP. Because of the drug’s ability to reduce tissue hypoxia, women are often prescribed Riboxin during pregnancy, reviews after taking it indicate its high effectiveness.

Taking this drug promotes active tissue regeneration, which is especially important for the myocardium and gastrointestinal mucosa. "Riboxin" also reduces platelet aggregation, which is an indicator that determines blood clotting.

"Riboxin" is poorly soluble in alcohol and absolutely insoluble in water. In its pure form it is an odorless, white, slightly yellowish powder.

Indications for use

Take the drug in different dosages for the treatment of many diseases. As part of complex therapy for coronary heart disease, the drug "Riboxin" is prescribed, reviews of which indicate its effectiveness at absolutely any stage of this disease. In addition, the drug is indicated in recovery period after a myocardial infarction suffered by the patient.

Riboxin also comes to the rescue in the treatment of cardiomyopathies and myocarditis. Instructions for use, reviews from doctors and patients indicate that the drug does an excellent job of normalizing heart rate. Moreover, in the treatment of arrhythmia, which was caused by an overdose of other drugs, the greatest effect is achieved.

The medicine has found another application in the treatment of patients with uroporphyria, a disorder of metabolic processes in the body.

"Riboxin" can also be part of complex therapy for a number of liver diseases, which include cirrhosis, hepatitis, and fatty degeneration. In addition, the drug is prescribed to patients with toxic damage to liver cells caused by exposure of the body to various factors associated with professional activity or taking any medications.

Often cancer patients undergoing radiation therapy, prescribe "Riboxin". Feedback from patients after taking the drug confirms its effect, which is to reduce adverse reactions during radiation therapy.

The drug is part of the complex therapy of diseases of the visual organs, in particular open-angle glaucoma.

For excessive physical activity, the drug "Riboxin" is also indicated, reviews of which, and only positive ones, were left by a considerable number of athletes.

Contraindications

First of all, you should understand that, even if you know your diagnosis for sure, self-medication with this drug is not recommended. Prescription of "Riboxin" should be carried out only by a qualified doctor and on an individual basis.

The main contraindication to taking the drug is individual intolerance or increased sensitivity to the active ingredients that are included in the composition.

The drug is contraindicated in patients with metabolic disorders purine bases and uric acid, as well as in patients with gout. The fact is that the drug can provoke an attack of gout, as well as cause various adverse reactions during treatment with chemotherapy drugs. Therefore, the use of the drug by patients undergoing chemotherapy should be under the strict supervision of the attending physician, and the amount of uric acid in the patient’s blood should be regularly checked.

Adverse reactions

The most common side reaction of the body to treatment with Riboxin is an allergic reaction, which is manifested by slight itching and redness skin. After stopping the use of the product, the allergy goes away immediately.

With a long course of treatment with Riboxin, as mentioned earlier, patients with impaired uric acid metabolism and kidney disease may develop gout. In this case, it is necessary to stop taking the drug and carry out therapy to combat inflammatory processes in the joints.

Currently, research questions the benefit of long-term use of the drug. However, patients and doctors do not agree with this: experience shows the effectiveness of long-term use.

Any medication must be taken strictly according to the instructions and only after it has been prescribed by a doctor. Riboxin is no exception. Reviews from doctors and patients indicate that as a result of an overdose of the drug, a rash, redness and itching may appear, as well as increased heart rate, heaviness in the chest and others discomfort. But all these symptoms are not dangerous and disappear immediately with a decrease in the concentration of the drug “Riboxin” in the blood. Indications for use, reviews of the drug and serious attitude treatment will only lead to a positive effect.

Directions for use and dosage

"Riboxin" tablets should be taken before eating. The daily dose in the first days of treatment is 0.6-0.8 g (1 tablet 3-4 times a day). In the following days, if there are no negative reactions from the body, the daily dose can be increased to 2.4 g. The duration of the course of treatment should be determined by the attending physician, sometimes the duration of treatment is up to 3 months, depending on the disease. For example, patients with uroporphyria should take Riboxin 800 mg daily for 4-12 weeks.

The product is available not only in tablets, but also in the form of a 2% injection solution, which is administered intravenously. The solution can be administered either by stream (very slowly) or by drip (50-60 drops per minute). On the first day of treatment, a solution of 10 ml must be administered only once. Further, the dosage can be increased to 20 ml several times a day if no negative side reactions have been identified and the patient feels well.

In order to administer the required dose of “Riboxin” by drip, it must be dissolved in glucose or 5% sodium chloride (volume - up to 250 ml). The duration of treatment is 1.5-2 weeks.

Indications for use during pregnancy

Being an antioxidant, antihypoxant and a good tool for improving metabolic processes in tissues, “Riboxin” is especially important during gestation.

The drug can be prescribed to support cardiac activity during periods of increased stress. Often, the Riboxin solution is administered to women directly during childbirth, since it is at this moment that the load on the heart is greatest. It is indicated for use in pregnant women with liver disease and gastritis. Moreover, the drug can reduce unpleasant symptoms and normalize gastric secretion.

If fetal hypoxia is detected, Riboxin can also be prescribed during pregnancy. Reviews about a decrease in the degree of oxygen starvation of the fetus after taking the drug confirm its effectiveness in this regard.

In the absence of any adverse reactions, pregnant women are prescribed 1 tablet 3-4 times a day for one month.

Contraindications during pregnancy

During pregnancy, many women are prescribed the drug "Riboxin", reviews of which indicate the advisability of taking it during this period. However, some are confused by the fact that in the instructions for the drug you can often find information that it is contraindicated during pregnancy. But you shouldn’t be upset or scared, because the contraindications are based only on the absence clinical trials in this area. In addition, today there is a lot of evidence of the successful use of Riboxin during pregnancy. The drug has no pathological effect on either the mother or the fetus, therefore, there is no reason to be concerned. The only contraindication may be individual intolerance to the components of the drug. But, despite the harmlessness of "Riboxin", we should not forget that only a doctor can prescribe the drug.

"Riboxin" in bodybuilding

Not only for the purpose of treatment various diseases the drug is used. As food additives Riboxin is used for athletes in bodybuilding. Reviews about the harmlessness of the drug and its positive impact on the body allows it to be used by supporters of doping-free sports.

Being a precursor of ATP, it activates reduction and oxidative processes, due to which metabolism and energy supply to tissues are activated. In addition, oxygen saturation of tissues improves.

Bodybuilders use Riboxin to gain weight. Reviews from other athletes indicate that by using the drug, it is possible not only to build muscle mass, but also to maintain it.

The effect of the drug on the body of athletes

When using "Riboxin" the athlete's body has a complex effect:

• Energy processes in the body and metabolism improve.
• The risk of hypoxia of organs and tissues is significantly reduced.
• At the cellular level, the ability to regenerate tissue increases.
• Tissue respiration and blood flow improves.
• The work of the heart muscle is significantly improved, thereby reducing the risk of myocardial ischemia.

Dosage of the drug during sports

Thanks to the use of the drug, it is much easier for the athlete to cope with difficult physical exercise In addition, he becomes stronger and more resilient. However, it is important to take the dosage of a medicine such as Riboxin responsibly. The instructions and reviews from doctors say that an athlete should start taking the drug with small doses, thereby checking the reaction of his body to this medicine. The first few days you need to take up to four tablets during the day before meals. If there are no adverse reactions within three days, the daily dose can be gradually increased to 14 tablets. The duration of the course should not exceed three months, after which it is not recommended to take the drug for several months to give the body a rest.

Interaction with other drugs

The simultaneous use of Riboxin and cardiac glycosides can prevent the occurrence of disruptions in the heart, as well as enhance the inotropic effect.

Use with Heparin enhances the effectiveness and duration of the latter's effects.

When using the drug in the form of injections, you should remember that it is incompatible with alkaloids: as a result of their mixing, insoluble compounds are formed. It is not recommended to combine the injection solution with other drugs: undesirable effects may occur. chemical reaction components with each other.

The drug is also incompatible with vitamin B6: simultaneous use deactivates both compounds.

Composition and release form

Riboxin contains the following substances:

• active ingredient - inosine;
• excipients - sucrose, methylcellulose, potato starch, stearic acid.

This drug is available in 3 forms:

1. Pills. One cardboard box may contain 10, 20, 30, 40 and 50 tablets. They have a round shape and a yellowish color.
2. Solution for injections 2%. One package contains only 10 ampoules.
3. Capsules. One box may contain 20, 30 and 50 capsules.

Average cost of Riboxin

The price depends on the dosage and release form. The cost of the medicine varies from 20 to 300 rubles. Tablets cost about 40 rubles. Injection solution and capsules are much more expensive; the price for 10 ampoules is approximately 150 rubles.

Indications for use

Taking Riboxin should only be started after a specialist has prescribed it. Indications for the use of the drug are quite extensive; it can be taken in the following cases:

1. For the treatment of coronary heart disease.
2. For the treatment of cardiomyopathies and myocarditis.
3. In order to normalize heart rate. The greatest effect is achieved in the treatment of arrhythmia, which is caused by an overdose of certain medications.
4. For the treatment of uroporphyria.
5. As part of the complex treatment of liver diseases (hepatitis, fatty degeneration, cirrhosis, toxic damage to liver tissue).
6. For the treatment of open-angle glaucoma.
7. While undergoing radiation therapy. The drug reduces side effects chemotherapy and facilitates its course.
8. With increased physical activity, which can negatively affect the patient’s health.

In each case, the duration of use and dosage of the medicine are different. These factors must be determined on a case-by-case basis.

Who can take Riboxin?

Many people are interested in the question of why Riboxin is prescribed. It is prescribed to adults who suffer from coronary heart disease, arrhythmia, who have suffered a myocardial infarction and in other cases.

The drug should not be taken by children, as well as during pregnancy and breastfeeding. The safety of the drug in these cases has not been established.

Method of use of the drug

Before using the medicine, you should carefully study the instructions for use. Riboxin should be taken before meals with a sufficient amount of warm liquid. The daily dose is calculated individually.

First, the intake begins with a small dose (0.6-0.8 g). If there are no side effects, then the dosage should be gradually increased to 2-4 g. That is, taking the tablets is as follows:

• for the first 2-3 days you should take 1 tablet 3-4 times a day;
• then 2 tablets 3-4 times a day;
• subsequently 3 pieces 3-4 times a day.

The course of treatment lasts from 1 to 3 months.

In addition to tablets, you can also purchase injection solutions. They are intended for intravenous administration. You can administer it in two ways: dropwise (droplets per minute) and stream (in this case, the solution must be administered slowly). The dosage of Riboxin also needs to be increased gradually - from 10 to 20 ml twice a day. The course of treatment in this case lasts a day.

Contraindications and side effects

• gout;
• impaired absorption of galactose and glucose;
• hyperuricemia;
• sugar deficiency;
• fructose intolerance;
• the presence of hypersensitivity to some components of the drug.

In general, patients tolerate Riboxin well. In rare cases, allergies (urticaria, itching, redness, Quincke's edema) and an increase in uric acid levels may occur. Sometimes taking the drug can cause an exacerbation of gout. Side effects also include cardiac disorders - arterial hypotension and tachycardia.

Use with caution in patients who suffer diabetes mellitus or renal failure.

special instructions

Let us note once again that before you start taking Riboxin, you should carefully study the instructions. There are several guidelines that will help reduce the possibility of side effects and complications. And also increase the effectiveness of the drug. These include:

1. During treatment, you need to check the level of uric acid in the blood.
2. Patients with diabetes should take into account that one tablet contains 0.0064 XE.
3. The drug does not affect brain activity.
4. Immunosuppressants (azathioprine, cyclosporine) reduce the effectiveness of Riboxin.
5. Taking the medication does not affect driving and does not affect attention.

In pharmacies, tablets are sold only with a prescription. It is forbidden to take Riboxin on your own. Uncontrolled reception The drug can worsen the course of the underlying disease and also lead to complications.

Analogs

In terms of therapeutic effect and structure, Riboxin tablets are similar to the following drugs:

As you can see, there are many analogues. However, consumers still give preference to Riboxin. Firstly, it has more best effect, secondly, it has a low cost.

Reviews about the drug

Most reviews about the use of Riboxin from both doctors and patients are positive. The medicine has proven itself in the treatment of certain heart diseases, as well as liver pathologies and alcoholism.

There are also negative reviews. Almost all of them are associated with side effects, in particular allergic reactions. However, after stopping the drug, the allergy quickly goes away.

Do not forget that before using Riboxin, you should always consult your doctor.

Riboxin - instructions for use

Indications for use

1. For the treatment of coronary heart disease, the medicine is prescribed as part of complex therapy. Moreover, the application this drug indicated at any stage of the disease, as well as in the recovery period after the patient has suffered a myocardial infarction.

2. Long-term use of the drug is indicated for the treatment of myocarditis and cardiomyopathies.

3. To normalize heart rhythm (treatment of arrhythmia). Moreover, the greatest effect can be achieved in the treatment of arrhythmia caused by an overdose of certain drugs.

4. For the treatment of patients diagnosed with uroporphyria (problems with metabolic processes in the body).

5. As part of complex therapy for a number of liver diseases. Riboxin can be prescribed to patients with cirrhosis, hepatitis, fatty degeneration, as well as those who have toxic damage to liver cells caused by taking any medications or exposure to harmful factors associated with professional activities.

6. As part of complex therapy for diseases of the visual organs (open-angle glaucoma).

7. Riboxin is often prescribed to cancer patients undergoing radiation therapy malignant neoplasms internal organs. The use of this drug helps to reduce the severity of adverse reactions of this radiation therapy and facilitate its course.

8. In cases of excessive physical activity, which can negatively affect the human body as a whole.

Contraindications for use and adverse reactions

Directions for use and dosage

Riboxin during pregnancy

Riboxin in bodybuilding

• the body's metabolism and energy processes improve;
• the risk of hypoxia of tissues and organs is significantly reduced;
• tissue regeneration is enhanced at the cellular level;
• blood flow and tissue respiration improves;
• the work of the heart muscle is improved and maintained, and the risk of myocardial ischemia is reduced.

Riboxin is directly involved in protein synthesis, which is especially important for the growth and development of muscle mass.

Riboxin

Description current as of 10/28/2014

• Latin name: Riboxin
• ATX code: C01EV
• Active ingredient: Inosine
• Manufacturer: Binnopharm ZAO (Russia); Asfarma (Russia); Ozon LLC (Russia); Irbit Chemical Pharmaceutical Plant (Russia); Borisov Medical Preparations Plant (Republic of Belarus).

Compound

1 tablet of the pharmaceutical product contains:

• Riboxin – 0.2 g;
• Calcium stearate;
• Potato starch;
• Powdered sugar;
• Opadry II Yellow coating mixture - Indigo carmine (E 132), Lactose monohydrate, Titanium dioxide (E 171), Macrogol (polyethylene glycol 3000), Quinoline yellow (E 104), Iron oxide (E 172).

Composition of solution for injection:

Release form

• 2% solution for injection in ampoules of 10 ml (total content of the main active ingredient – ​​200 mg). The cardboard box holds 10 ampoules.
• TabletsRiboxin yellow color, covered with a shell with a biconvex surface. In the cross section, two layers are clearly visible. The drug is packaged in contour cellular blisters made of aluminum foil or PVC 10 tablets. A pack contains 1, 2, 3, or 5 plates.
• Riboxin Lect - capsules containing Inosine - 0.2 g. 20, 30 or 50 pieces are placed in a cardboard package.

pharmachologic effect

What is Riboxin?

Riboxin is an anabolic drug that has nonspecific antihypoxic and antiarrhythmic effects. The main active component of the drug is Inosine (Inosine - INN or international generic name pharmaceutical products) is a chemical precursor of adenosine triphosphate (ATP), which is directly involved in the metabolism of glucose and promotes the activation of metabolic processes in conditions of oxygen deficiency (“oxygen starvation”).

Mechanism of action of the drug

The biologically active substances included in the drug activate the metabolism of pyruvic acid (PVA), which ensures normalization tissue respiration even in the absence of the required amount of ATP. The active components also affect the enzymatic component of metabolic processes - when they enter the human body, they stimulate the activity of xanthine dehydrogenase, which in turn catalyzes oxidative reactions followed by the formation of uric acid from hypoxanthine.

The benefits and harms of Riboxin

The positive effects of the pharmaceutical drug include the effect of the main components of Riboxin on metabolism in the myocardium (heart muscle). Thus, the therapeutic properties of the drug are manifested in an increase in the energy balance of cardiomyocytes, accelerated formation of nucleotides, which is manifested in enhanced processes of physiological regeneration of cardiac tissue. That is, the medicine helps to normalize the contractile activity of the myocardium and a more complete course of diastole, when the heart completely relaxes due to the ability to bind with chemical chains of calcium ions that penetrate into the intracellular space during systole.

TO negative influences Riboxin can be attributed to a change in the physiological sequence of the metabolic cycle. That is, the active components of a pharmaceutical drug, coming from outside, make adjustments to metabolic processes. As a rule, qualified specialists try, if possible, not to interfere in this area of ​​​​biochemistry human body, since the therapeutic effects can cause very adverse consequences for the patient. However, in the presence of a pathological process that destructively affects the heart muscle (the vital “pump” of the circulatory system), a change in metabolism is necessary, because non-intervention will lead to a much worse outcome.

Wikipedia about Riboxin

The free encyclopedia of knowledge on the Internet also reveals some aspects of the pharmacological action of the drug. In particular, all cardiac effects are described biologically active ingredients, included in Riboxin. In addition, on the page about this medicine there is information about the effect on the cellular component of the blood coagulation system - Inosine reduces platelet aggregation, thereby reducing the risk of developing thrombosis and thromboembolism. The regenerative therapeutic properties of the pharmaceutical drug extend not only to the heart muscle, but also to the mucous membrane of the gastrointestinal tract.

Separately, it should be noted that Inosine pranobex is a type of drug that has immunostimulating activity and a nonspecific antiviral effect. The drug suppresses harmful pathogens such as viruses herpes simplex, CMV (cytomegalovirus), measles and T-cell lymphoma virus type 3, human enterocytopathogenic virus and many others. The mechanism of this action lies in the inhibition of ribonucleic acid and inhibition of the biological catalyst dihydropteroate synthetase, which manifests itself in the suppression of viral replication and increased production of interferons by lymphocytes that destroy pathological organisms.

Pharmacodynamics and pharmacokinetics

At orally Riboxin is well and almost completely absorbed into gastrointestinal tract. When administered intravenously, the pharmaceutical drug is quickly distributed into tissues that need ATP. Regardless of the route of administration, unused active ingredients are metabolized in the liver, where the final stages of metabolic biochemical reactions take place. A small amount of Riboxin is excreted in urine, feces and bile.

Indications for use of Riboxin

Indications for use of Riboxin tablets:

• Complex treatment of coronary heart disease (angina pectoris, coronary insufficiency, condition after myocardial infarction);
• Intoxication with cardiac glycoside drugs;
• Cardiomyopathies of various origins;
• Myocarditis;
• Rheumatic, congenital and acquired heart defects;
• Cardiac arrhythmia;
• Myocardial dystrophy of infectious or endocrine origin (especially against the background of heavy physical exertion);
• Coronary atherosclerosis;
• Nonspecific liver diseases (hepatitis, fatty degeneration parenchymal organ, cirrhosis);
• Drug and alcohol liver damage;
• Urocoproporphyria;
• Prevention of a decrease in the number of leukocytes during irradiation;
• Gastric ulcer and duodenum;
• Open-angle glaucoma with normalized intraocular pressure.

Specific indications for the use of injections:

• Urgent pathological conditions of cardiac arrhythmias;
• Surgeries on an isolated kidney (as a means of pharmacological protection in case of temporary absence of blood circulation);
• Arrhythmias of unknown etiology in medicine;
• Acute radiation exposure to prevent the development of changes in the blood formula.

Contraindications

• Hereditary or acquired intolerance to the constituent components of a pharmaceutical drug;
• Individual hypersensitivity to active ingredients medicine;
• Gout;
• Kidney failure;
• Hyperuricemia (increased amount of uric acid salts in the blood).

Side effects

As a rule, the medicine is well tolerated, only in isolated cases the following side effects are observed:

Instructions for use of Riboxin (Method and dosage)

Riboxin tablets, instructions for use

Tablets are used orally, before meals. The dosage, as a rule, is set individually in view of the characteristics of the metabolism of the active components and indications for conservative therapy. However, there are certain general schemes treatment with this pharmaceutical drug, according to which daily dose for adults and children over 12 years of age is 0.6-2.4 g per day. Sanitation begins with small dosages (about 0.6-0.8 g - 1 tablet 3-4 times a day), and then, if the medicine is well tolerated and has a beneficial effect on the body, the dose is gradually increased over 2-3 days .

The maximum amount of the drug taken is 2.4 g per day - 4 tablets 3 times per day. This dosage is achieved after 2 months of the course. conservative treatment, the entire duration of which, as a rule, lasts from 1 to 3 months and is regulated taking into account individual indications for therapeutic intervention.

Separately, it should be noted how to take tablets for urocoproporphy, since the pathophysiology of this disease is associated with an increase in uric acid salts in biological fluids and secretions. Riboxin, in turn, accelerates the metabolism of urates, activating the enzymatic oxidation of hypoxanthine. Therefore, in order to avoid deposits and the formation of stones, the dosage of the drug is 0.8 g per day - 1 tablet 4 times a day and must be strictly observed during conservative treatment.

Riboxin injections, instructions for use

Slow drip parenteral administration or rapid jet injections are used, depending on individual indications and the urgency of the pathological condition. If injections are chosen by the attending physician, then first apply minimum dosage in 200 mg of Riboxin (10 ml of 2% solution for injection) 1 time per day. At acute disorders cardiac rhythm, a single injection of Inosine mg (10-20 ml of 2% solution) intravenously can be used.

The dosage of jet administration is increased only if the drug is well tolerated. The maximum amount of the drug can be 400 mg of Riboxin (two ampoules of a 2% solution) 1 or 2 times a day. The duration of the course is selected individually (according to the general protocol - days).

If you use Riboxin intravenously (intravenously), then before its administration, a 2% solution of the drug must be diluted in 5% glucose or a hypotonic sodium chloride solution (concentration - 0.9%) to obtain 250 ml of medicinal liquid. The rate of administration is drops per minute.

Instructions during pregnancy

Riboxin is used intravenously for pregnant women, because in this way its effects are revealed more fully. The dosage and duration of the course of conservative therapy is selected strictly individually in each individual case, based on the results of various clinical studies and the opinion of qualified specialists.

How to use Riboxin Lect?

The dosage and duration of treatment with this variation of the pharmaceutical drug do not differ from the generally accepted protocols for therapeutic care with Riboxin. However, the Lect form of the drug is not used as an emergency correction of dysfunction of the heart muscle or other organs, since its effects develop somewhat more slowly.

Overdose

The medical pharmacological literature does not describe cases of overdose with this pharmaceutical drug.

Interaction

The combined use of a drug with cardiac glycosides enhances the inotropic effect of the latter and prevents the development of such an adverse effect drug treatment, as the occurrence of arrhythmia, for which Riboxin is sometimes prescribed together with this group of pharmaceuticals.

Simultaneous use of Riboxin with anticoagulants such as heparin increases the duration of their therapeutic action.

The drug is completely incompatible with acids and alcohols, pyridoxine hydrochloride or vitamin B6, since both are deactivated chemical compounds, salts of heavy metals, plant alkaloids. The latter, when interacting with Riboxin, form insoluble and non-removable compounds due to the detachment of the alkaloid base.

Terms of sale

The drug belongs to list B, therefore it can be purchased only upon presentation of a certified receptor form. Certain old-fashioned pharmacy stalls may even require a prescription in Latin.

Storage conditions

The medicine should be stored in its original packaging at a temperature not exceeding 25 degrees Celsius in a dry place inaccessible to young children. Also, the drug should be protected from exposure to direct sunlight.

Best before date

special instructions

Riboxin in bodybuilding

The pharmaceutical drug is classified as a metabolic agent and biochemical stimulant, so the drug can be used to gain weight, improve physical performance and increase strength. Riboxin was actively used in sports back in the 70s. The following types of nutrition for bodybuilders are known, which are actively sold to this day:

• Premium Inosine;
• Ultimate nutrition;
• Inosine mega-pro;
• Inosine life extension;
• Cell-tech hardcore.

How to take Riboxin for bodybuilding?

IN sports nutrition A tablet form of the drug is used, which is administered orally before meals. The dosage ranges from 1.5 to 2.5 g per day. As in therapeutic purposes, the number of tablets taken should be gradually increased from the starting dosage of 0.6-0.8 g 3-4 times a day to 2.5 g. Riboxin for athletes should be used for from 4 weeks to 1.5-3 months.

To enhance the effect of the drug on the myocardium and reduce the period of mid-mountain and climatic adaptation, Potassium orotate and Riboxin can be used together. In this case, the dosage potassium salt orotic acid is 0.25-0.5 g 2-3 times a day before meals (course duration is days), and Riboxin is used according to the above scheme.

Riboxin in veterinary practice

The drug is non-specific in its pharmaceutical nature, therefore it can also be used in veterinary therapeutic practice. Often the drug is used for dogs to eliminate heart failure, treat myocarditis and endocarditis, improve the metabolic abilities of the muscular organ with myocardosis and heart defects, which are very common senile problems in animals.

How should animals take Riboxin?

As a rule, the drug is administered intramuscularly, because this is the most rational route of administration in veterinary practice. The dosage is 0.1-0.2 g of the drug per 10 kg of animal weight 3 times a day. The course of conservative treatment lasts about a month. Repeated prescriptions of Riboxin are possible for a more thorough correction of metabolism or elimination of deep degenerative changes.

Riboxin's analogues

Riboxin analogues constitute a small pharmaceutical group with an identical main active ingredient - Inosie-F, Inosine, Riboxin bufus, Ribonosine. As a rule, the price of these drugs is even lower, which is why Riboxin tablets can be replaced with these analogues for greater savings.

With alcohol

Riboxin IV (intravenously) should not be combined with drinking alcohol, as this is fraught with side effects from the list above or the emergence of new adverse consequences of conservative therapy with a pharmaceutical drug.

Riboxin during pregnancy (and lactation)

The pharmaceutical drug is actively prescribed during the most critical periods for a woman, which, as a rule, plunges expectant mothers into slight bewilderment. Even after reading the instructions, many questions remain, the main one of which, of course, is what Riboxin is for during pregnancy. The drug improves energy supply and tissue metabolism, that is, it provides the woman and fetus with more active intake beneficial nutrients during the period when they suffer from deficiencies. This is one of the main aspects of using Riboxin.

Also, the active ingredients help reduce harm from the so-called “oxygen starvation,” which is a common complication during pregnancy. Arises pathological condition, because respiratory system women supplies vital gas to two organisms. But such a powerful need for oxygen runs counter to the capabilities of the lungs and bronchial tree. Therefore, the antihypoxic effect of Riboxin comes in handy, and this is the second, but no less important aspect of using the drug during pregnancy.

Among the therapeutic properties of a pharmaceutical drug, a significant part consists of effects on cardiac activity. Riboxin normalizes myocardial contractile activity, regulates the metabolic needs of cardiomyocytes, and helps enhance trophic processes. Thus, the drug plays the role of preventive sanitation, since it is not uncommon for pregnant women to develop such pathological processes, such as arrhythmias, tachycardias and other rhythm disturbances of the heart muscle.

How to take Riboxin for pregnant women?

The dosage and duration of use of a pharmaceutical drug during pregnancy is always selected individually based on diagnostic test results, ultrasound data and other physiological parameters. As a rule, Riboxin is administered intravenously during pregnancy, but in medical literature and on thematic forums for pregnant women, cases of prescribing the tablet form of the drug are described.

Reviews about Riboxin

Reviews about Riboxin characterize the drug from a positive point of view in their overwhelming majority. The drug has an extremely small list of possible side effects, which seems even more insignificant if we consider the entire range of indications for the use of Riboxin. The active components make it possible to effectively fight and stop the pathological effects of most common nosological entities affecting the vital circulatory system and its “main pump”.

However, the therapeutic effects of the drug are not limited to effects on the myocardium. The active components promote active regeneration of the mucous membrane in destructive diseases of the gastrointestinal tract, and how often in modern world you will meet a person without at least light form gastritis. The positive effects also extend to the blood system, metabolic processes in the kidneys and other organs and systems.

Reviews from doctors only confirm the favorable therapeutic capabilities of the pharmaceutical drug. Of course, there are those in the medical community who postulate very dubious harmful aspects of using Riboxin, but the vast majority of qualified specialists express their “for” and universally prescribe the drug in the fight against various pathological conditions.

Reviews of this pharmaceutical drug from athletes and bodybuilders are negative. To gain weight and improve physical performance, Riboxin was used back in the 70s, after which biochemistry stepped far forward and reliably proved that the active components do not have an anabolic effect on muscle mass. Accordingly, a course of taking the drug can help only in the form of the so-called “placebo” effect. Athletes, calculating their results, notice the lack of influence and therefore scribble unpleasantly colored reviews left and right.

The situation changes in the opposite direction when it comes to the use of Riboxin during pregnancy. During a course of pharmaceutical therapy Negative consequences critical conditions are more easily tolerated, since the body’s adaptive abilities are significantly expanded due to the properties of the active components. The trophism of tissues and organs is also improved, therefore the color and nature of the skin, the functioning individual systems does not become a cause for concern. Based on the majority of positive reviews, we can safely say that pregnancy is much easier with Riboxin.

Riboxin price, where to buy

The pharmaceutical drug can be purchased almost everywhere at pharmacy kiosks in the territory Russian Federation. The price of Riboxin tablets is 20 rubles, and the price of Riboxin in ampoules is 80 rubles per package.

You can buy the medicine in other countries, for example, the price of Riboxin in Ukraine for the tablet form fluctuates on average about 1 hryvnia, and a solution for injection or infusion can be purchased 1 hryvnia.

Antiarrhythmic drug Riboxin - principles of action and instructions for use

The drug Riboxin is an effective stimulator of energy metabolism in the cells of the human body.

This drug is indispensable for many pathologies, including diseases of the heart, liver, and gastrointestinal tract.

It strengthens the myocardium, restores metabolism, improves blood supply to the coronary vessels and generally has a beneficial effect on health.

Today we will analyze in detail what Riboxin treats, instructions for use and at what pressure this drug is effective.

Riboxin: what is it prescribed for?

First of all, let’s figure out whether Riboxin is a vitamin or a medicine. The basis of the drug is the active substance inosine (precursor of adenosine triphosphate acid) is a nucleide, an element that is part of human cells. This compound is the main source of energy for all tissues of the human body. After all, without its action, oxygen deficiency occurs and the heart stops.

When inosine (0.2 g in one tablet) enters the body in the form of a medicine, it fills its cells with vitamins and minerals necessary for full functioning. And yet, why is Riboxin prescribed?

The drug is prescribed to patients diagnosed with ailments such as:

• cardiac ischemia;
• coronary atherosclerosis;
• myocardial dystrophy;
• cirrhosis of the liver;
• hepatitis (acute, chronic);
• diseases of the visual organs;
• uroporphyria (metabolic disorder);
• stomach ulcer;
• liver intoxication.

Does Riboxin increase or decrease blood pressure? The drug lowers arterial pressure and, often, Riboxim is simply irreplaceable for hypertension. But is it worth taking it if you have low blood pressure? A condition such as hypotension requires additional consultation with your doctor.

The drug significantly reduces the body's reactions during radiation therapy used to get rid of cancer. This medicine is also used by athletes during serious physical exertion that can undermine the body.

Rules of application

Can Riboxin be administered intramuscularly? Can. Moreover, as a rule, the drug is administered intramuscularly, since this is the most rational route of administration.

In addition to intravenous administration, it is used in the form of tablets or capsules.

Orally for adults and children over 12 years of age, the drug is prescribed 1 tablet or capsule 3-4 times a day, which is 0.6–0.8 g. If the medicine is well tolerated, then its dosage is gradually increased.

At first, take 2 tablets 3 times a day, then switch to 4 tablets 3 times a day. An exception is a congenital metabolic disorder (urocoproporphyria). So, in the presence of such an illness, the optimal dose is 1 tablet 4 times a day. This medicine requires long-term use: 1-3 months.

Riboxin tablets

With drip or jet IV administration at the initial stage of treatment, the patient is prescribed 200 mg of Riboxin once a day. Then, provided the medication is well tolerated, the dosage is increased to 400 mg 1-2 times a day. The course of treatment is generally 10 days.

If intravenous drip administration is necessary, then in order to avoid attacks of tachycardia, the drug is administered slowly (approximately 50 drops per minute).

The liquid form of Riboxin is produced in ampoules (20 m) by such pharmaceutical companies as Biosintez OJSC, Novosibkhimpharm OJSC, Arterium and others.

In the form of capsules and tablets (200 ml), Riboxin is also produced by various companies, including Darnitsa, Vero, Ferein. The tablets are taken half an hour before meals with plain water.

Riboxin: contraindications and side effects

A significant advantage of the drug is the minimal number of side effects.

Quite rare allergic manifestations, expressed in the form of hives and an itchy rash.

At the same time, the allergy manifests itself in a more severe form if the drug is administered intravenously. But even with minimal signs of allergy, the drug must be discontinued.

Also, long courses of taking Riboxin can provoke a gout attack. This disease, accompanied by severe pain, is characterized by the accumulation of uric acid salts in the joints. One of the elements of the drug, purine, is involved in the metabolism of uric acid. Therefore, its significant accumulation in the body, as a rule, leads to gout.

In some cases, the use of Riboxin is simply unacceptable. So, contraindications to taking the medicine are:

• some kidney diseases;
• leukemia in the final stages;
• late stages of pregnancy;
• lactation;
• gout;
• excessive levels of uric acid in the blood;
• increased sensitivity to the components of the drug.

Use during pregnancy

Many years of medical experience show that taking the drug during pregnancy helps to avoid many unpleasant situations.

Thus, expectant mothers often develop heart problems. Therefore, for the harmonious functioning of the heart muscle, pregnant women are prescribed Riboxin, and if required, the medicine is administered during childbirth.

Also Riboxin - excellent remedy to combat gastritis and liver problems. And what is important, it is recommended to take the drug for the normal formation of the fetus. Indeed, in the case of hypoxia, the child suffers from a lack of oxygen, and it is precisely this drug that can cope with the current problem.

Treatment of heart diseases

Almost all heart disorders are caused by dysfunction of the myocardium.

Metabolic changes occur in the myocardium due to disruptions in the blood supply to the heart and blood flow. Such disorders usually lead to arrhythmia, angina pectoris, heart attack, hypertension, myocardial dystrophy and other diseases.

And if the heart lacks energy to function flawlessly, then the delivery of the components of the drug Riboxin into the myocardial muscle makes up for this deficiency. The medication is prescribed for many heart ailments, but it is of great importance for angina pectoris (a type of coronary artery disease).

Use for liver and stomach diseases

The drug brings the cells of the stomach walls into the appropriate state.

Therefore, this drug accelerates recovery and prevents exacerbation of gastric and duodenal ulcers.

The drug also restores liver cells (hepatocytes). This means that this drug is indispensable for acute and chronic liver diseases (hepatitis, alcohol impairment...). In general, a non-toxic drug can improve the patient’s condition with these and many other diseases.

Compatibility with other drugs

You can also safely take Riboxin with medications such as Nitroglycerin, Nifedipine, Furosemide. It is unacceptable to use the drug with vitamin B6.

It is worth noting that many patients are interested in whether it is possible to take the medications Riboxin and Concor together. They have good compatibility and are often prescribed together to people with diseases of the cardiovascular system.

Video on the topic

Video review of the drug Riboxin:

Based on the indications for use and taking into account good tolerability, the drug Riboxin remains one of the most popular in medical practice. Moreover, this product has an affordable price and is distributed in pharmacy chains. But in order to really improve your health and not harm yourself, you should consult a doctor before using the drug.

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Riboxin in bodybuilding

Previously, athletes especially often used a drug such as Riboxin. And currently this drug is used by bodybuilders and powerlifters. It is used as a supplement to the main course of steroids. Thus, Riboxin can be considered the first among non-steroidal anabolics.

To describe it scientifically, riboxin is a nucleic acid that is a purine base that can be compared to guanine and adenine. Riboxin is present in organ meats and brewer's yeast.

Properties of Riboxin

Riboxin has a lot of positive properties.

• First of all, it helps to increase the capacity of hemoglobin in the blood.
• Participates in metabolic processes (read more about metabolism in this article).
• Stimulates the production of insulin, which promotes the absorption of carbohydrates into the heart muscle.
• Dilates blood vessels.
• Increases endurance and, as a result, the intensity of training (which is especially valued by bodybuilders).
• Strengthens the immune system, stimulates regenerative processes in muscle tissue.

Riboxin can provide all this. Since muscles require a large amount of energy to work, riboxin is its source, replacing ATP. Under the influence of this drug, metabolic processes increase, tissue respiration improves due to the antihypoxic effect.

After taking Riboxin, the metabolic process increases, tissues better tolerate the lack of oxygen, and it is better absorbed by tissue cells. It also has a beneficial effect on the heart muscle, which is important during high physical activity.

Use of the drug

Doctors use Riboxin to treat diseases of the stomach, heart, liver and duodenum, as well as to treat the liver after prolonged drinking. It will be useful to take Riboxin after a course of taking anabolic steroids, but it is also possible to take Riboxin along with steroids in parallel.

Another indication for the use of Riboxin is glaucoma. Using this drug improves visual function. Since sprains may occur in bodybuilding, constant strengthening of blood vessels is necessary, which is facilitated by Riboxin. There is an opinion that Riboxin is the best anabolic agent, although not everyone agrees with this. But if we compare non-steroidal and non-hormonal drugs, then Riboxin can rightfully be called the best drug for bodybuilding.

Soviet weightlifters once widely used Riboxin, but subsequently the effectiveness of the drug was not confirmed. You can achieve good results by taking the drug together with orotate, B vitamins, methiuracil and glycerophosphate. Moreover, this is true for both naturalists and “chemists”.

It is especially important that Riboxin can become a worthy substitute for creatine at a lower cost. In this case, side effects are reduced only to individual intolerance. This may manifest itself in the form of allergic reactions. But, as a rule, this drug is well tolerated, provided the dosage is followed.

Taking Riboxin

The drug is available in tablet form, which must be taken half an hour before meals. Start taking one tablet for four days. During this time, the body’s tolerance to the drug will become clear. Further, the dosage is increased to two and a half grams per day. There is a universal formula with which the working dosage is calculated: per 10 kg of weight 0.15 g. This will be daily dosage, which is divided into several steps.

It is especially advisable to take Riboxin a couple of hours before training. The duration of use is from one to three months, after which it is necessary to take a break.

To summarize: Riboxin is advisable to use during particularly intense training for bodybuilders, as it promotes rapid recovery of the body. Thanks to a large number positive properties and versatility, the use of this drug is recommended for most athletes, allowing them to achieve high results in a relatively short period of time.

Riboxin in bodybuilding - instructions for use

10/05/2016 pharmacology 20,728 Views

The ability to provide a positive therapeutic effect, harmlessness to the body, positive reviews and low price allow Riboxin to maintain popularity since the 70s. The drug is successfully used to treat heart diseases, maintain the health of pregnant women, lose weight and in bodybuilding to form beautiful muscles.

Compound

• riboxin;
• calcium stearate;
• starch;
• methylcellulose;
• sucrose.

The tablets are coated with a coating consisting of indigo carmine, iron oxide, lactose monohydrate, titanium dioxide, macrogol, quinyl yellow.

Inosine is the main active compound.

Release form

Riboxin is produced in the form:

1. Double-layer tablets. The biconvex tablets with a yellow or yellow-orange coating have a rough surface. Under the shell there is a white core. The tablets are sealed in blisters of 10 pieces. 1-5 blisters are placed in one pack.
2. Solution for injection (two percent). The volume of each ampoule is 10 ml. 10 ampoules are placed in a cardboard box.
3. Capsules. 20, 30 or 50 capsules are packaged in cardboard boxes.

pharmachologic effect

Riboxin is an effective anabolic steroid that can saturate the body with oxygen and eliminate arrhythmia (restore heart rhythm).

It supports the metabolism of glucose and pyruvic acid, stimulates protein synthesis, normalizes tissue respiration, and activates metabolism during oxygen starvation and ATP deficiency.

The medicine improves blood circulation. As a result, the tissues are saturated with oxygen, receiving good nutrition. Metabolic processes are established in them and energy supply is restored. A person feels a surge of vitality.

The drug eliminates tissue hypoxia, which is important during pregnancy, when cells experience constant shortage oxygen. For severe injuries that cause immobilization, Riboxin is administered intravenously. Nutrients are quickly transported with the blood stream to the cells of stationary areas of the body.

The medicine will not allow platelets to stick together and form conglomerates. Prevents blood clots from forming and improves blood clotting. At the same time, blood quality increases, heart rate normalizes and stabilizes, tissue regeneration occurs (increased restoration of the mucous membranes of the gastrointestinal tract and myocardium).

The drug acts as an immunostimulant and nonspecific antiviral agent. It inhibits development pathogenic microorganisms. Fights measles virus, herpes, lymphoma and other pathogens of infectious diseases. Under its influence, the body intensively produces lymphocytes that kill pathological microorganisms.

Riboxin has a beneficial effect on liver function. The cells of the organ, saturated with oxygen, are actively restored. It is used in complex therapy for heart diseases.

Indications for use

The medicine is taken in complex therapy and as an independent remedy. It is used for treatment serious pathologies heart, digestive organs, liver. It is recommended in bodybuilding. The drug should not be taken without a doctor's prescription.

Riboxin is prescribed when the following pathologies are detected:

1. Liver cirrhosis, hepatitis with damage and degeneration of tissue structures.
2. Ischemia. Riboxin is taken at any stage of the disease and myocardial infarction.
3. Myocarditis and cardiomyopathies.
4. Arrhythmia (irregular heart rhythm). Riboxin is especially effective for arrhythmia that occurs due to drug and alcohol intoxication.
5. Myocardial dystrophy of various etiologies.
6. Peptic ulcer disease.
7. Uroporphyia (metabolic imbalance).
8. Fatty degeneration and toxic damage to liver tissue.
9. Eye diseases (for example, open-angle glaucoma).
10. Cancer. The drug is prescribed after radiation, chemotherapy and surgical operations. It relieves side effects caused radical methods treatment malignant tumors. Reduces the concentration of leukocytes after radiation therapy. Supports the body, alleviates the condition of cancer patients.
11. Tolerating inadequate physical activity in bodybuilding, which negatively affects the body. Riboxin relieves physical stress, replenishes energy, and gives strength to the bodybuilder.

Contraindications

Riboxin is contraindicated in people with hypersensitivity to its components. An allergic reaction is expressed by redness of the skin and itching. Allergy symptoms disappear as soon as the patient stops taking the medication.

It is not prescribed to those who suffer from gout or who have an imbalance of uric acid and purines. Long-term use of the drug in people with kidney disease leads to the development of gout. If gout occurs, stop taking the medication. The patient is prescribed medications to relieve inflammation in the joints.

Treatment of patients undergoing chemotherapy is carried out under the strictest medical supervision. Doctors monitor blood tests and determine the concentration of uric acid in it. This allows you to avoid the occurrence of side effects (attack of gout) from the use of potent drugs, the effect of which is enhanced by Riboxin.

Research by scientists indicates that Riboxin is not suitable for long-term therapy. However, medical practitioners claim that long-term treatment with the drug allows one to achieve optimal results.

Side effects do not occur if the patient takes Riboxin, adhering to the instructions and recommendations of the doctor (does not exceed the permissible dosage).

In case of an overdose, the skin begins to itch, a rash and redness appear on it. The patient has a feeling of heaviness in the chest, the heart beats intensely. Such signs do not pose a serious danger to life. As soon as the concentration of inosine in the blood drops, the symptoms disappear.

Riboxin is not a harmless drug; self-medication is unacceptable. Prescribing the drug, the form of its administration (tablets, injections, capsules), dosage is the prerogative of a qualified doctor.

Side effects

Riboxin can provoke:

• in case of overdose, intoxication of the body and tachycardia, which quickly disappears after discontinuation of the drug;
• allergies (skin itching, urticaria);
• uric acid imbalance, gout attack;
• arterial hypertension;
• general weakness.

Instructions for use

The tablets are taken before meals. At the beginning of therapy, take 1 tablet 3-4 times a day. This scheme is used for 1-2 days. If there are no side effects, the dosage is increased to 2.4 g per day (corresponds to 4 tablets). The course of treatment is determined by the doctor. It can last 1-4 months (depending on the individual characteristics of the individual patient).

Patients with urocoproporphyria are prescribed no more than 0.8 g (200 mg per dose) of the drug per day for 1-3 months. The disease is characterized by an increase in the concentration of uric acid and its salts. Inosine increases the rate of urate metabolism, which leads to the formation and deposition of stones. Therefore, the prescribed dosage (1 tablet 4 times a day) is not exceeded.

The solution for injection is intended for intravenous administration. It is injected in a stream or dripped. A stream of liquid is slowly injected into the vein. On the first day, use only one ampoule (10 ml). If the patient does not experience any adverse reactions, the dose is doubled (the solution is administered twice a day, 10 ml; or once a day the entire volume (20 ml) at once).

For drip administration, the medicine is mixed with a glucose solution (5%) or sodium chloride (0.9%). The volume of liquid should be 250 ml. The solution is fed dropwise/min. Duration of treatment days.

Overdose

To avoid an overdose, Reboxin should be taken according to the regimen drawn up by doctors, or follow the recommendations given in the instructions. Increased doses lead to skin itching, reddening of the epithelium, and the appearance of rashes. They can provoke an irregular heartbeat and heaviness in the chest.

An overdose is not too dangerous for health. If symptoms of intoxication appear, stop taking the drug and consult a doctor.

Interaction

There are both drugs with which Riboxin is perfectly combined, and medications that are incompatible with it:

1. The simultaneous use of cardiac glycosides and Riboxin eliminates arrhythmia and increases the force of contraction of the heart muscle.
2. The drug increases the effectiveness of Heparin and increases the time of its effect on pathological foci.
3. Riboxin is compatible with furosemide, nitroglycerin, spironolactone, nifedipine.
4. The injection solution must not be mixed with alkaloids. As a result of their interaction, insoluble compounds are formed.
5. Contraindicated simultaneous administration vitamin B6 and Riboxin. When combining drugs, they are completely deactivated.
6. The injection solution is diluted only in recommended solvents (glucose, sodium chloride). Otherwise, undesirable chemical reactions between substances occur in the solution.

Riboxin in bodybuilding

To achieve high results in bodybuilding, athletes often take approved drugs. Building muscle mass and pumping up muscles cannot be achieved without performing grueling physical exercises.

To facilitate the formation beautiful body bodybuilders drink harmless supplements. Thanks to dietary supplements, athletes are able to withstand crazy pace, less tired.

Riboxin helps to form beautiful muscles without harm to the body. Taking it, bodybuilders quickly recover from the hardest strength training. They experience a surge of vital energy.

Riboxin, once in the athlete’s body, enhances metabolism, activates biochemical and energy processes, promotes cell and tissue regeneration, and increases endurance.

The drug has a vascular strengthening effect. Thanks to it, sprains and injuries are less likely to occur. Under conditions of excessive force loads, the heart muscle has time to relax between contractions.

Riboxin is the most effective anabolic in bodybuilding among other non-steroidal and non-hormonal medications. It is an excellent alternative to creatine, which is an unsafe and expensive supplement.

How to take Riboxin

The tablets are taken one minute before meals. Start taking the drug with one tablet. If no adverse reactions occur within 1-2 days, the dosage is adjusted to 2.5 g per day.

The calculation for taking tablets is made as follows: per 10 kg of weight of an athlete or bodybuilder, use 0.15 g of the drug. Take the tablets 1.5-2 hours before starting strength training. Riboxin is taken in courses. Their duration is 1-4 months. The rest between courses should be at least 2-3 months.

Potassium orotate and Riboxin in bodybuilding

Bodybuilders often take Riboxin in tandem with Potassium Orotate, a safe drug. When used together, medications achieve complete absorption and give a lasting result.

A single dose for bodybuilders is 2 tablets. This is quite enough to achieve optimal sporting achievements. Strength training after joint use of drugs is effective.

Athletes feel a lift in their spirits. Their performance is activated and their endurance increases. Complex therapy gives more tangible results: simultaneous intake of Riboxin and Potassium Oratate with vitamins, adaptogens, and metabolites.

Asparkam and Riboxin in bodybuilding

Asparkam – complex medicine, popular among those who actively lose weight and play sports. It contains magnesium and potassium aspartate. Magnesium aspartate maintains protein balance and transports energy in the required volume. Potassium aspartate normalizes metabolism at the cellular level.

During strength training, Asparkam is a very useful supplement that relieves fatigue. An unexhausted bodybuilder trains more effectively and can withstand heavy loads with ease.

When an athlete is in shape, he is able to achieve optimal performance. The feeling of strength allows you to build muscle mass and create beautiful reliefs on your body.

To avoid fluid accumulation in tissues, Asparkam is taken together with diuretics. At the same time, toxins leave the body, and useful material are held.

Taking Asparkam starts with 1-2 tablets 3 times a day. An increase in the dosage of the drug is carried out based on the results of tests and general condition bodybuilding athlete. For each bodybuilder, the course and regimen for taking Asparkam is strictly individual (prepared by their sports doctor).

Analogs

Preparations similar to Riboxin contain substances identical to inosine. They may contain Inosie-F, Riboxin bufus, Ribonosine.

Analogues of the drug include:

• Piracetam;
• Enap;
• Panangin.

Panangin is close in effect to Riboxin. It nourishes the heart and improves its functioning. Normalizes the activity of the cardiovascular system.

The cost of Riboxin is low. The price of its analogues is even lower. The cost of the drugs does not exceed 100 rubles.

"Riboxin" is a drug that can have a positive effect on the energy supply of body tissues and metabolism.

It normalizes heart rate and coronary circulation, and also increases the energy balance of the myocardium. By participating in glucose metabolism, Riboxin stimulates metabolic processes in the absence of ATP. Because of the drug’s ability to reduce tissue hypoxia, women are often prescribed Riboxin during pregnancy, reviews after taking it indicate its high effectiveness.

Taking this drug promotes active tissue regeneration, which is especially important for the myocardium and gastrointestinal mucosa. "Riboxin" also reduces platelet aggregation, which is an indicator that determines blood clotting.

"Riboxin" is poorly soluble in alcohol and absolutely insoluble in water. In its pure form it is an odorless, white, slightly yellowish powder.

Indications for use

The drug is taken in various dosages to treat many diseases. As part of complex therapy for coronary heart disease, the drug "Riboxin" is prescribed, reviews of which indicate its effectiveness at absolutely any stage of this disease. In addition, the drug is indicated in the recovery period after a myocardial infarction suffered by the patient.

Riboxin also comes to the rescue in the treatment of cardiomyopathies and myocarditis. Instructions for use, reviews from doctors and patients indicate that the drug does an excellent job of normalizing heart rhythm. Moreover, in the treatment of arrhythmia, which was caused by an overdose of other drugs, the greatest effect is achieved.

The medicine has found another application in the treatment of patients with uroporphyria, a disorder of metabolic processes in the body.

"Riboxin" can also be part of complex therapy for a number of liver diseases, which include cirrhosis, hepatitis, and fatty degeneration. In addition, the drug is prescribed to patients with toxic damage to liver cells caused by exposure to various factors on the body associated with professional activities or taking certain medications.

Often, cancer patients undergoing radiation therapy are prescribed Riboxin. Feedback from patients after taking the drug confirms its effect, which is to reduce adverse reactions during radiation therapy.

The drug is part of the complex therapy of diseases of the visual organs, in particular open-angle glaucoma.

For excessive physical activity, the drug "Riboxin" is also indicated, reviews of which, and only positive ones, were left by a considerable number of athletes.

Contraindications

First of all, you should understand that, even if you know your diagnosis for sure, self-medication with this drug is not recommended. Prescription of "Riboxin" should be carried out only by a qualified doctor and on an individual basis.

The main contraindication to taking the drug is individual intolerance or hypersensitivity to the active ingredients that are included in the composition.

The drug is contraindicated in patients with metabolic disorders of purine bases and uric acid, as well as in patients with gout. The fact is that the drug can provoke an attack of gout, as well as cause various adverse reactions during treatment with chemotherapy drugs. Therefore, the use of the drug by patients undergoing chemotherapy should be under the strict supervision of the attending physician, and the amount of uric acid in the patient’s blood should be regularly checked.

Adverse reactions

The most common side reaction of the body to treatment with Riboxin is an allergic reaction, which is manifested by slight itching and redness of the skin. After stopping the use of the product, the allergy goes away immediately.

With a long course of treatment with Riboxin, as mentioned earlier, patients with impaired uric acid metabolism and kidney disease may develop gout. In this case, it is necessary to stop taking the drug and carry out therapy to combat inflammatory processes in the joints.

Currently, research questions the benefit of long-term use of the drug. However, patients and doctors do not agree with this: experience shows the effectiveness of long-term use.

Any medication must be taken strictly according to the instructions and only after it has been prescribed by a doctor. Riboxin is no exception. Reviews from doctors and patients indicate that an overdose of the drug may result in the appearance of a rash, redness and itching, as well as increased heartbeat, heaviness in the chest and other unpleasant sensations. But all these symptoms are not dangerous and disappear immediately with a decrease in the concentration of the drug “Riboxin” in the blood. Indications for use, reviews of the drug and a serious attitude towards treatment will only lead to a positive effect.

Directions for use and dosage

"Riboxin" tablets should be taken before eating. The daily dose in the first days of treatment is 0.6-0.8 g (1 tablet 3-4 times a day). In the following days, if there are no negative reactions from the body, the daily dose can be increased to 2.4 g. The duration of the course of treatment should be determined by the attending physician, sometimes the duration of treatment is up to 3 months, depending on the disease. For example, patients with uroporphyria should take Riboxin 800 mg daily for 4-12 weeks.

The product is available not only in tablets, but also in the form of a 2% injection solution, which is administered intravenously. The solution can be administered either by stream (very slowly) or by drip (50-60 drops per minute). On the first day of treatment, a solution of 10 ml must be administered only once. Further, the dosage can be increased to 20 ml several times a day if no negative side reactions have been identified and the patient feels well.

In order to administer the required dose of “Riboxin” by drip, it must be dissolved in glucose or 5% sodium chloride (volume - up to 250 ml). The duration of treatment is 1.5-2 weeks.

Indications for use during pregnancy

Being an antioxidant, antihypoxant and a good tool for improving metabolic processes in tissues, “Riboxin” is especially important during gestation.

The drug can be prescribed to support cardiac activity during periods of increased stress. Often, the Riboxin solution is administered to women directly during childbirth, since it is at this moment that the load on the heart is greatest. It is indicated for use in pregnant women with liver disease and gastritis. Moreover, the drug can reduce unpleasant symptoms and normalize gastric secretion.

If fetal hypoxia is detected, Riboxin can also be prescribed during pregnancy. Reviews about a decrease in the degree of oxygen starvation of the fetus after taking the drug confirm its effectiveness in this regard.

In the absence of any adverse reactions, pregnant women are prescribed 1 tablet 3-4 times a day for one month.

Contraindications during pregnancy

During pregnancy, many women are prescribed the drug "Riboxin", reviews of which indicate the advisability of taking it during this period. However, some are confused by the fact that in the instructions for the drug you can often find information that it is contraindicated during pregnancy. But you shouldn’t be upset or scared, because the contraindications are based only on the lack of clinical research in this area. In addition, today there is a lot of evidence of the successful use of Riboxin during pregnancy. The drug has no pathological effect on either the mother or the fetus, therefore, there is no reason to be concerned. The only contraindication may be individual intolerance to the components of the drug. But, despite the harmlessness of "Riboxin", we should not forget that only a doctor can prescribe the drug.

"Riboxin" in bodybuilding

The drug is used not only for the purpose of treatment for various diseases. Riboxin is used as a dietary supplement for athletes in bodybuilding. Reviews about the harmlessness of the drug and its positive effect on the body allow it to be used by supporters of doping-free sports.

Being a precursor of ATP, it activates reduction and oxidative processes, due to which metabolism and energy supply to tissues are activated. In addition, oxygen saturation of tissues improves.

Bodybuilders use Riboxin to gain weight. Reviews from other athletes indicate that by using the drug, it is possible not only to build muscle mass, but also to maintain it.

The effect of the drug on the body of athletes

When using "Riboxin" the athlete's body has a complex effect:

• Energy processes in the body and metabolism improve.
• The risk of hypoxia of organs and tissues is significantly reduced.
• At the cellular level, the ability to regenerate tissue increases.
• Tissue respiration and blood flow improves.
• The work of the heart muscle is significantly improved, thereby reducing the risk of myocardial ischemia.

Dosage of the drug during sports

Thanks to the use of the drug, heavy physical activity is much easier for the athlete, in addition, he becomes stronger and more resilient. However, it is important to take the dosage of a medicine such as Riboxin responsibly. The instructions and reviews from doctors say that an athlete should start taking the drug with small doses, thereby checking the reaction of his body to this medicine. The first few days you need to take up to four tablets during the day before meals. If there are no adverse reactions within three days, the daily dose can be gradually increased to 14 tablets. The duration of the course should not exceed three months, after which it is not recommended to take the drug for several months to give the body a rest.

Interaction with other drugs

The simultaneous use of Riboxin and cardiac glycosides can prevent the occurrence of disruptions in the heart, as well as enhance the inotropic effect.

Use with Heparin enhances the effectiveness and duration of the latter's effects.

When using the drug in the form of injections, you should remember that it is incompatible with alkaloids: as a result of their mixing, insoluble compounds are formed. It is not recommended to combine the injection solution with other medications: undesirable chemical interaction of the components with each other may occur.

The drug is also incompatible with vitamin B6: simultaneous use deactivates both compounds.

Drug: RIBOXIN

Active substance: inosine
ATX code: C01EB
KFG: A drug that normalizes myocardial metabolism and reduces tissue hypoxia
ICD-10 codes (indications): I20, I21, K71, K73, K74
Reg. number: LP-000240
Registration date: 02/16/11
Owner reg. cred.: TATHIMPHARMPREPARATIONS (Russia)

DOSAGE FORM, COMPOSITION AND PACKAGING

Film-coated tablets light yellow to yellow-orange, round, biconvex, slightly rough; on a cross section, two layers are visible: the core is white or white with a slightly yellowish tint and the shell is light yellow to yellow-orange.

	1 tab.
inosine	200 mg

Excipients: potato starch 54.1 mg, methylcellulose 3.2 mg, sucrose 10 mg, stearic acid 2.7 mg.

Shell composition: opadry II yellow (polyvinyl alcohol, titanium dioxide, talc, macrogol 3350 (polyethylene glycol 3350), iron (III) oxide, aluminum varnish based on quinoline yellow) - 8 mg.

10 pieces. - contour cell packaging (5) - cardboard packs.
25 pcs. - contour cell packaging (2) - cardboard packs.

INSTRUCTIONS FOR USE FOR SPECIALISTS.
The description of the drug was approved by the manufacturer in 2011.

PHARMACHOLOGIC EFFECT

Inosine belongs to the group of drugs that regulate metabolic processes. The drug is a precursor for the synthesis of purine nucleotides: adenosine triphosphate and guanosine triphosphate.

It has antihypoxic, metabolic and antiarrhythmic effects. Increases the energy balance of the myocardium, improves coronary circulation, and prevents the consequences of intraoperative renal ischemia. It is directly involved in glucose metabolism and promotes the activation of metabolism under conditions of hypoxia and in the absence of adenosine triphosphate.

Activates the metabolism of pyruvic acid to provide normal process tissue respiration, and also promotes the activation of xanthine dehydrogenase. Stimulates the synthesis of nucleotides, enhances the activity of some Krebs cycle enzymes. Penetrating into cells, it increases the energy level, has a positive effect on metabolic processes in the myocardium, increases the strength of heart contractions and promotes more complete relaxation of the myocardium in diastole, resulting in an increase in stroke volume of blood.

Reduces platelet aggregation, activates tissue regeneration (especially the myocardium and the mucous membrane of the gastrointestinal tract.

PHARMACOKINETICS

Well absorbed in the gastrointestinal tract. Metabolized in the liver with the formation of glucuronic acid and its subsequent oxidation. A small amount is excreted by the kidneys.

INDICATIONS

Prescribed to adults in the complex treatment of coronary heart disease, after myocardial infarction, cardiac arrhythmias caused by the use of cardiac glycosides.

Prescribed for hepatitis, cirrhosis, fatty liver caused by alcohol or drugs and urocoproporphyria.

DOSING REGIME

Prescribed for adults orally, before meals.

The daily dose when taken orally is 0.6-2.4 g. In the first days of treatment, the daily dose is 0.6-0.8 g (200 mg 3-4 times a day). If well tolerated, the dose is increased (on days 2-3) to 1.2 g (0.4 g 3 times a day), if necessary - to 2.4 g per day.

Course duration is from 4 weeks to 1.5-3 months.

For urocoproporphyria, the daily dose is 0.8 g (200 mg 4 times a day). The drug is taken daily for 1-3 months.

SIDE EFFECT

Possible allergic reactions in the form of urticaria, skin itching, skin hyperemia (drug discontinuation required). Rarely, during treatment with the drug, the concentration of uric acid in the blood increases and exacerbation of gout (with long-term use).

CONTRAINDICATIONS

Hypersensitivity to the drug, gout, hyperuricemia. Fructose intolerance and glucose/galactose malabsorption syndrome or sucrase/isomaltase deficiency.

Carefully. Kidney failure, diabetes mellitus.

PREGNANCY AND LACTATION

The safety of using the drug Riboxin during pregnancy and lactation has not been established. The use of Riboxin is contraindicated during pregnancy. During treatment with Riboxin, breastfeeding should be stopped.

SPECIAL INSTRUCTIONS

During treatment with Riboxin, the concentration of uric acid in the blood and urine should be monitored.

Information for patients with diabetes: 1 tablet of the drug corresponds to 0.00641 bread units.

Does not affect the ability to drive vehicles and operate machinery that requires increased concentration attention.

DRUG INTERACTIONS

Immunosuppressants (azathioprine, antilympholine, cyclosporine, thymodepressin, etc.) when used simultaneously reduce the effectiveness of Riboxin.

CONDITIONS OF VACATION FROM PHARMACIES

The drug is available with a prescription.

CONDITIONS AND DURATION OF STORAGE

In a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.

Best before date. 3 years. Do not use after the expiration date indicated on the package.