Chorionic gonadotropin 5000 units for how long. The use of chorionic gonadotropin for men. How to use hCG - dosage

Composition and form of release

1 vial with lyophilized powder for the preparation of an injection solution contains chorionic gonadotropin 500 or 1000 IU, complete with a solvent (isotonic sodium chloride solution 0.9% in 1 ml ampoules); in a pack of cardboard 5 sets.

Characteristic

White or almost white powder.

pharmachologic effect

pharmachologic effect- gonadotropic.

It has a gonadotropic, predominantly luteinizing effect. In women, promotes ovulation, formation and hormonal activity corpus luteum. In men, it stimulates the interstitial cells of the gonads, primarily the Leydig cells, thereby enhancing the synthesis of testosterone and partially spermatogenesis, activates the development of the genital organs and secondary sexual characteristics, promotes testicular descent in cryptorchidism.

Indications for Chorionic Gonadotropin for Injection

Decreased function of the gonads in men and women due to impaired activity of the hypothalamus and pituitary gland: interstitial-pituitary insufficiency (Simmonds disease, Sheehan syndrome, panhypopituitarism of any etiology, adiposogenital dystrophy, pituitary dwarfism with symptoms of sexual infantilism, hypogonadotropic hypogonadism with signs of eunuchoidism), anovulatory dysfunction ovaries and associated infertility, later sexual development, habitual and threatened abortion in the first trimester of pregnancy, dysfunctional uterine bleeding in women of childbearing age, bilateral cryptorchidism in children, unilateral cryptorchidism after surgical treatment with signs of eunuchoidism, differential diagnosis primary and secondary hypogonadism in men.

Contraindications

pituitary tumors, inflammatory diseases genital area, hormonally active tumors of the gonads, absence of gonads (congenital or after surgery), early attack menopause, thrombophlebitis, breastfeeding.

Use during pregnancy and lactation

At the time of treatment should stop breastfeeding.

Side effects

allergic reactions, headache, depression, an increase in the testicles located in the inguinal canals, preventing their further descent; premature puberty(with prolonged treatment or use in high doses in male adolescents with impaired physical and sexual development), degeneration of the sex glands (with unreasonably long-term use of the drug for cryptorchidism, especially if indicated surgical intervention), atrophy of the seminiferous tubules (due to inhibition of FSH production as a result of stimulation of the production of androgens and estrogens), a decrease in the number of spermatozoa in the ejaculate (with abuse of the drug in men).

Interaction

It is used in combination with menopausal gonadotropin in the treatment of infertility.

Dosage and administration

V / m, in doses of 500-3000 IU / day.

Men - 2-3 times a week, courses of 4 weeks at intervals of 4-6 weeks. Spend 3-6 courses within 6-12 months; in diagnostic purposes- 1500-3000 IU / day for 5 days.

Women at anovulatory cycles, starting from the 10-12th day of the cycle - 3000 IU 2-3 times with an interval of 2-3 days or 1500 IU 6-7 times every other day.

With pituitary dwarfism with symptoms of sexual infantilism - 500-1000 IU 1-2 times a week for 1-2 months in repeated courses.

With cryptorchidism, children under 10 years old - 500-1000 IU, 10-14 years old - 1500 IU 2 times a week for 4-6 weeks in repeated courses.

Overdose

In women, ovarian hyperstimulation syndrome may occur with an increase in their size.

Precautionary measures

Use with caution in boys puberty, patients with ischemic heart disease, arterial hypertension, renal failure, bronchial asthma, migraine.

special instructions

In women with the occurrence of ovarian hyperstimulation syndrome, the administration of the drug should be discontinued.

Storage conditions of the drug Chorionic gonadotropin for injection

In a place protected from light, at a temperature not exceeding 20 ° C.

Keep out of the reach of children.

Shelf life of the drug Chorionic gonadotropin for injection

4 years.

Do not use after the expiry date stated on the packaging.

Synonyms of nosological groups

Category ICD-10	Synonyms of diseases according to ICD-10
E23.0 Hypopituitarism	Anovulatory disorders
	Simmonds disease
	Simmonds-Glinsky disease
	Secondary hypogonadism in men
	Secondary hypogonadotropic hypogonadism
	hypogenitalism
	hypogonadism
	Hypogonadism hypogonadotropic
	Hypogonadism pituitary
	Hypogonadism in men
	Hypogonadotropic hypogonadism
	Hypopituitrism
	Infantilism pituitary
	Dwarfism cerebral-pituitary
	Pituitary cachexia
	Cachexia diencephalic-pituitary
	Larona dwarfism
	Pituitary insufficiency
	Growth retardation in children with hypopituitarism
	Panhypopituitarism
	Primary hypogonadism
	Primary hypogonadotropic hypogonadism
	Kallmann syndrome
	Fertile Eunuch Syndrome
	Sheen's syndrome
	Sheehan syndrome
	Sheehan's syndrome
E23.6.0* Adiposogenital syndrome	Adiposogenital dystrophy
	Adiposogenital syndrome
E23.7 Disorder of pituitary gland, unspecified
	Diagnosis of disorders of the gonadotropic function of the pituitary gland
	Interhypophyseal insufficiency
	Violation of the pituitary gland
	Anterior pituitary insufficiency
	Cerebrohypophyseal disease
E25 Adrenogenital disorders	Adrenogenital syndrome
	Congenital dysfunction of the adrenal cortex
	Macrogenitosomia in boys
	Aper-Galle syndrome
	Crook-Aper-Galle syndrome
E28 Ovarian dysfunction	Dysfunction of the gonads
	Impaired ovarian function
	Non-functioning ovaries
	Decreased function of the gonads
	estrogen deficiency
E28.3 Primary ovarian failure	Hypogonadism ovarian (primary)
	Hypofunction of the ovaries
	Estrogen deficiency
	Lack of estrogen in the body
	estrogen deficiency
	Estrogen deficiency
	Primary ovarian dysfunction
	Estrogen deficiency states
E29 Testicular dysfunction
	Androgenic dysfunction
	Dysfunction of the gonads
	Violation of the function of the gonads in men
	Underdevelopment of the genital organs in men
	Primary hypogonadism in men
E29.1 Testicular hypofunction	Androgen deficiency
	Androgen deficiency
	Leydig cell aplasia
	Hypogonadism testicular (primary)
	Testicular hypoplasia
	Hypofunction of the gonads in men
	Eunuchoidism
	Androgen deficiency
	Androgen deficiency in men
	Leydig cell deficiency
	testosterone deficiency
	Decreased function of the gonads
E30.0 Delayed puberty	late sexual development
	Late puberty
E34.3 Short stature [dwarfism], not elsewhere classified	Pituitary dwarfism
	Pituitary dwarfism
	growth retardation
	Stunted growth in children
	Dwarfism
	Nanism pituitary
	Nanism disproportionate
	Nanism associated with external factors
	Disruption of the growth process
	Growth disorder
	Violation of the secretion of endogenous hormone with growth retardation
	Growth disorders
	Growth hormone deficiency
	Deficiency of endogenous growth hormone
	short stature
N94.6 Dysmenorrhea, unspecified	Algodysmenorrhea
	Algomenorrhea
	Pain syndrome with spasms of smooth muscles
	Pain syndrome with spasms of smooth muscles (renal and biliary colic, intestinal spasm, dysmenorrhea)
	Pain syndrome with spasms of smooth muscles internal organs
	Pain syndrome with spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasm, dysmenorrhea)
	Pain during menstruation
	Painful irregular periods
	Pain during menstruation
	Pain during menstruation
	Dysalgomenorrhea
	Dysmenorrhea
	Dysmenorrhea (essential) (exfoliative)
	menstrual disorder
	Menstrual cramps
	Painful menstruation
	Metrorrhagia
	Violation menstrual cycle
	Menstrual irregularities
	Primary dysalgomenorrhea
	Prolactin-dependent menstrual irregularity
	Prolactin-dependent menstrual dysfunction
	Disorder of the menstrual cycle
	Spastic dysmenorrhea
	Functional disorders of the menstrual cycle
	Functional disorders of the menstrual cycle
N97 Female infertility	Anovulatory infertility
	female infertility
	Infertility due to hyperprolactinemia
	Infertility of ovarian origin
	Infertility due to hypothalamic-pituitary dysfunction
	marriage is fruitless
	Hyperprolactinemic infertility
	Hyperprolactinemia with infertility
	Female infertility with anovulation
	Stimulation of the growth of one follicle
	Functional infertility
	endocrine infertility
O20.0 Threatened abortion	Abortion threatening
	Miscarriage threatening
	Spastic condition with risk of abortion
	Threatened abortion
	Threatened miscarriage in the first trimester of pregnancy
	Threatened spontaneous miscarriage
	Threat of abortion
	Threat of spontaneous miscarriage

HCG (human chorionic gonadotropin) is a hormone that in large numbers produced by the chorion of the embryo. This happens within a week after fertilization. A sufficient amount indicates a normally developing pregnancy. Chorionic gonadotropin is also present in a small amount in the body of men and women who are not expecting a child. The drug containing this hormone is widely used in medicine for various purposes.

What is human chorionic gonadotropin and what is it responsible for? This substance belongs to gonadotropic hormones. It plays an important role in the body of men and women. This substance is on a par with and follicle-stimulating hormones, but differs from them in structure. Human chorionic gonadotropin is a complex protein base in which carbohydrate elements are present. It mostly consists of amino acids.

Chorionic gonadotropin, produced in large quantities in the body of a pregnant woman, is excreted from her body in the urine unchanged. From there it is mined to create medicines that are subsequently used for various purposes.

Pharmacological properties of gonadotropin

A drug containing gonadotropin hormone has the following pharmacological properties:

• promotes the synthesis of sex hormones in the female body, which occurs in the ovaries. In men, the same process occurs in the testicles. Especially chorionic gonadotropin affects the production of testosterone;
• promotes ovulation;
• stimulates spermatogenesis in men;
• provides normal functioning corpus luteum, which is especially important during pregnancy;
• affects normal development genital organs in men and women, provokes the appearance of secondary sexual characteristics.

Indications for the use of the drug gonadotropin

Features of the use of gonadotropin is that they can eliminate many problems that are found in men and women. This drug is most often used to eliminate the decrease in sexual function, which occurs when there is a violation normal operation pituitary and hypothalamus.

The most common indications for the use of this medicinal product are considered:

• Simmonds syndrome, which causes severe hormonal disorders different kind;
• necrosis of the pituitary gland observed after childbirth. This condition is a complication that occurs as a result of significant bleeding;
• different type, regardless of the reasons for its occurrence;

• adiposogenital dystrophy with emerging obesity, which is localized in the area of ​​\u200b\u200bthe brain where the hypothalamus and pituitary gland are located;
• caused by insufficient function of the pituitary gland, which is accompanied by sexual disorders;
• accompanied by sexual dysfunction, the absence of normally developed genitalia;
• infertility in women, which is associated with the absence of ovulation;

• with delayed sexual development in men and women;
• with threats of spontaneous abortion in the first trimester of pregnancy in the presence of a fetus that develops normally;
• uterine bleeding in women of reproductive age;
• to stimulate the descent of the testicles into the scrotum in children;
• diagnosis of hypogonadism in the stronger sex.

The use of the drug gonadotropin in sports

Chorionic gonadotropin has anabolic properties. It is because of this that it began to be used in bodybuilding for a set muscle mass. Also, the drug containing this hormone affects in a special way, which stimulates the reduction of body fat. The human body begins to use more energy reserves what causes the weight loss effect. At the same time, the muscles do not undergo splitting, as can be observed in a natural process without external intervention.

Recent studies by scientists indicate that the use of this drug may be hazardous to human health. Chorionic gonadotropin produces a much smaller effect on gaining muscle mass than taking other steroids that belong to the anabolic series. To get a tangible result, it is necessary to administer large doses of the drug, which negatively affects the functioning of the body.

Gonadotropin for men is indicated only in cases where there is high risk testicular atrophy due to the use of anabolic steroids. In this case, it is recommended to use drugs in minimum dosage, which eliminates negative consequences for the body. They are taken after a long course of steroids (more than 1-2 months). At this time, it is also recommended to use vitamin complexes and lots of protein.

How to use the drug gonadotropin

Human chorionic gonadotropin is produced pharmaceutical companies in the form of a powder, which is intended for the preparation of a solution. To do this, a solvent (most often sodium chloride) is offered in the kit for the main drug. It must be introduced into an ampoule with powder, and then used for its intended purpose. The drug usually dissolves well within a few seconds. The resulting liquid is administered intramuscularly.

If the prepared solution is not completely used, then it must be moved to the refrigerator. Dry powder should be kept in a dark place out of the reach of children. The optimum temperature for this is no more than 20 ° C.

Half-life active substances the drug is several hours. The result from the use of one injection is saved long time– about 5-6 days.

Permissible dosages of gonadotropin

Instructions for use of this drug indicate the optimal dosage:

• women in the absence of ovulation, to stimulate this process with one injection - from 5000 to 10000 IU;
• stimulation normal life corpus luteum - maximum dose 5000 U (used on certain days of the menstrual cycle);
• during the IVF procedure during ovulation stimulation - 10,000 IU with one injection;
• with habitual miscarriage (before 8 weeks of pregnancy) the entire first trimester - the first dose of 10,000 IU, then 5,000 IU 2 times a week;
• with developmental delays in children (boys) - the maximum dose of 5000 IU for 3 months and more 1 time per week;
• in case of violation reproductive function in men - the maximum dose is 2000 IU 2-3 times a week for several months;
• during treatment hypogonadotropic hypogonadism- the maximum dose of 6000 IU 1 time per week;
• to assess the functions of the testicles in the diagnosis of certain conditions - 5000 units once;
• for lowering the testicles in boys under the age of 6 years - the maximum dose is 1000 IU 2 times a week for 1.5 months;
• for lowering the testicles in boys over 6 years old - 1500 IU twice a week for 1.5 months;
• with oligospermia - 5000 IU every week for 3 months.

Contraindications for use

Human chorionic gonadotropin is not used with therapeutic purpose in the following cases:

• ovarian cancer;
• hypersensitivity to any component;
• absence of glands reproductive system (congenital pathology, the result of the operation);
• hypothyroidism;
• menopause that came too early;
• tumors of various types (pituitary or hormone-dependent sex glands);
• thrombophlebitis;
• lactation;
• adrenal dysfunction;
• obstruction of the uterine tubes.

Also, with great care, this remedy is prescribed for hypertension, in adolescence, for the treatment of people with kidney failure, bronchial asthma, or frequent migraine episodes.

Side effects of gonadotropin

Chorionic gonadotropin 1500 IU dosage or any other can provoke the following side reactions:

• increased irritability;
• pain at the injection site;
• hyperemia;
• allergic reactions of various manifestations;
• headache;
• high fatigue;
• depressive states;
• inhibition of the normal functioning of the pituitary gland;
• in women, when taken in large doses, there is a syndrome of ovarian hyperstimulation, in men - swelling of tissues, sensitivity of the nipples, an increase in testicles;
• with prolonged use in men, inhibition of sperm activity is observed.

Reception features

With increasing doses of the drug in women, ovarian hyperstimulation syndrome often occurs, which is accompanied by an increase in their size.

it dangerous state, requiring symptomatic treatment. Major Complications given state- ascites and hydrothorax. In the treatment of infertility, this remedy is often used in combination with menopausal gonadotropin.

In the treatment of men, the ineffectiveness of the drug at a high concentration of FSH has been proven. unfounded long-term use means leads to negative consequences. When treating children, premature puberty may occur. If the hormone is administered for cryptorchidism, degeneration of the genital organs sometimes occurs.

Long-term use may cause the formation of specific antibodies. This is a dangerous condition that leads to a decrease in the concentration of the hormone. immune system. During pregnancy, this leads to interruption or premature birth. If this remedy was used to stimulate ovulation, the likelihood of the formation of two or more eggs increases several times.

It should also be borne in mind that after discontinuation of the drug in both men and women for a week, a pregnancy test will show a false positive result.

Manufacturers

Chorionic gonadotropin is produced by several pharmaceutical companies under different trade names:

• Moscow Endocrine Plant. It has generic name denoting the active substance;
• Pregnyl. Contains chorionic gonadotropin 500, 100, 1500, 3000 U in one vial. Manufacturer - the Netherlands;
• Profazi. Manufacturer - Switzerland;
• Ovitrelle. Manufacturer - Italy.

The description of these drugs is identical. They have the same range of applications and side effects. The tablet as a therapeutic component is not used. All funds are ready or semi-ready solution for injection.

Bibliography

1. Atlas by ultrasound diagnostics in obstetrics and gynecology. Dubile P., Benson K.B. 2009 Publisher: MEDpress-inform.
2. Metabolic syndrome and thrombophilia in obstetrics and gynecology. Makatsaria A.D., Pshenichnikova E.B. 2006 Publisher: MIA.
3. Arterial hypertension in pregnant women Preeclampsia (preeclampsia). Makarov O.V., Volkova E.V. RASPM; Moscow; TsKMS GOU VPO RGMU.-31 p.- 2010.
4. Herpetic infection, antiphospholipid syndrome and fetal loss syndrome. HELL. Makatsaria, N.V. Dolgushin, 2008, Moscow, "Triad-X".
5. obstetric risk. Maximum information - minimum danger for mother and baby Radzinsky V.E., Knyazev S.A., Kostin I.N. 2009 Publisher: Eksmo.

Most often, gonadotropin is used in sports and bodybuilding, but its use is much more extensive. For athletes, it helps to produce more testosterone, exhibits an anabolic effect, while for women, hCG therapy is sometimes required not only during pregnancy, but also before it. Restoration of the menstrual cycle, improvement of the corpus luteum, stimulation of follicles- all this requires the use this tool. How to take gonadotropin in all these cases, so as not to harm yourself?

Dosage and mode of taking hCG

Gonadotropin in tablets is not used, because it has low efficiency, therefore it is administered by injection into the muscle. Here it is absorbed faster, which means it begins to work more actively. You can make injections on your own, but only if you have the necessary skills so as not to damage other important areas near the muscle.

The dosage of the drug is selected in each case purely individually. In pharmacies, gonadotropin is usually provided in doses from 500 IU to 10,000 IU, which allows you to immediately dilute the right amount of the drug by making one injection.

The standard dosages of gonadotropin used will be given below, but it should be used only as directed by a doctor. We must not forget that wrong treatment this medicine can bring many problems, as well as delay the treatment of the underlying disease. So, standard dosages for various pathologies are usually the following:

• When stimulating the corpus luteum, it is enough to use hCG in the amount of 1500 IU for one day of ovulation (that is, on the third, sixth and ninth day), or to inject 5000 IU at a time.
• With threats of miscarriage, 10,000 IU are prescribed first, then therapy is continued weekly at 5,000 IU twice. Terms of application are strictly limited. You need to start and end treatment, respectively, from 8 to 14 weeks of pregnancy.
• Gonadotropin injections are also made to maintain pregnancy, if a woman had previously experienced habitual miscarriage. Dosage in this case similar to that prescribed for threatened miscarriage.
• Stimulation of follicle growth precedes further reproductive activities. In the latter case, a single injection of 10,000 IU of gonadotropin is sufficient to select a mature egg within 34 hours.
• In cases of developmental delay, hCG is prescribed in the amount of 3000-5000 IU for 3 months every week. This dosage is suitable for adolescents, but for men, hCG 500, 1500 or 2000 IU is more often used 2-3 times a week. The course of therapy is selected individually and can last 1.5-3 months.
• Hypogonadotropic hypogonadism is treated when combined with menotropins. Enter 1500-6000 IU of gonadotropin at a time.
• Up to 6 years of age, boys with cryptorchidism are injected with either 500 IU twice a week, or at a time 1000 IU for 6 weeks. After 6 years, the dosage of gonadotropin increases and will be 1500 IU, and the drug must be administered twice a week.

Rules for the injection of gonadotropin

HCG is sold in a pharmacy, usually in the form of a powder for injection, which is then diluted either with a special solution or with water for injection. Dilution of the drug at home is done as follows:

1. Remove the rubber protective cap without opening the vial;
2. Wipe it with alcohol;
3. Draw water for injection (2 ml) into a clean syringe and, without removing the cap from the bottle, pierce it with a needle and inject the liquid into it slowly;
4. Diluted medicine should not be shaken, left in the sun or warmed in any way;
5. Take the solution into the cavity without removing the syringe, and inject.

An injection of gonadotropin is done in the same way as any other intramuscular injection. The safest area is gluteal muscle, and not all, but only the upper part of it. In order not to hurt sciatic nerve, mentally draw a cross on the buttock.

The upper outer thigh is the best place for self intramuscular injection. Naturally, both before the procedure and after it, it is necessary to treat the area with alcohol.

The storage of the drug must also be approached correctly so that it does not deteriorate. So, chorionic gonadotropin should be stored in the refrigerator (not in the freezer!), Especially if it has already been diluted. You can choose another cool place for him, as long as the temperature is not higher than 10-12 degrees.

HCG injection is designed to compensate for the amount of human chorionic gonadotropin in the body with insufficient natural production. Injection involves the introduction of one of the drugs that have different commercial names. The list of such drugs includes: chorionic gonadotropin (Russia), Profazi (Switzerland), Pregnil (Netherlands or USA), Horagon (Germany), etc. The main purpose of such drugs is to influence hormonal background body and restore the functions of the genital organs. The need to inject hCG for women who want to become pregnant is explained by the normalization of the ovulatory process and the subsequent hormonal activity of the corpus luteum after the injection.

Chorionic gonadotropin: general information

HCG or human chorionic gonadotropin has two subunits in its structure: alpha and beta. The alpha subunit is structurally identical to the TSH, FSH, and LH subunits. The beta subunit has no analogues. It is she who is the basis of tests that determine pregnancy.

The production of the beta component of hCG occurs in the first weeks of pregnancy. And by the 11th week, its content grows thousands of times. After that, its level begins to gradually fall. For this reason, it is important to monitor human chorionic gonadotropin during the perinatal period. So the control of the hormone level allows you to timely determine its decrease or increase, which may indicate the development of certain pathologies of pregnancy (threat of interruption, ectopic pregnancy and etc.).

In addition, a woman registered for infertility must undergo an examination to detect antibodies to hCG. These antibodies do not allow the protein to function fully, which leads to a decrease in placental lacogen, estradiol, and progesterone. Due to chorionic gonadotropin, the rejection of the embryo, its death inside the mother's womb, is excluded. This is another argument in favor of monitoring its level. Patients who have antibodies to hCG in the blood are recommended to perform plasmapheresis and take advantage of the possibilities of in vitro fertilization.

Usually, the level of chorionic gonadotropin is monitored during pregnancy, which is normal in such a situation. However, testing for beta-CHG in some cases may be indicated for some non-pregnant women and even men. An analysis that detects chorionic gonadotropin in the blood is prescribed for men and non-pregnant women when it is necessary to confirm hormone-producing tumors.

For injection, chorionic gonadotropin is produced in the form of a solution or in the form of a lyophilisate (a solution is prepared from it). This protein is harvested for production hormonal drugs from the urine of pregnant women.

Indications for the use of hCG injections

The effectiveness of drugs with hCG was noted when the following conditions occur in women:

• dysmenorrhea;
• ovarian dysfunction;
• anovulatory infertility;
• corpus luteum deficiency;
• the threat of spontaneous miscarriage;
• inability to bear fruit;
• preparation for IVF;
• placenta formation.

The drug with hCG can act as additional funds with assisted reproductive techniques.

Recombinant hCG affects:

• on the ovaries and tissues to enhance the production of sex hormones;
• when stimulating ovulation.

Instructions for the use of HCG

The drugs are injected intramuscularly. It is permissible for a woman to give herself an hCG injection, but only if she knows how to do it. intramuscular injections. Otherwise, she will have to look for a person from her inner circle who could do it for her. If none of the options is possible, then you can go for injections in treatment room toy antenatal clinic, which the patient visits at the place of registration. But this option is not entirely convenient, since injections are prescribed for a long time, in whole courses, and the opportunity to visit the treatment room of the clinic is not always possible. Therefore, it is best to still find a person who can come to the house or do it yourself.

When stimulating ovulation, the doctor will recommend an injection of hCG into the stomach. It is much more painless and more convenient than when placing it in the buttock. To do this, measure the distance of about two fingers from the navel to the left and right. Having pinched the fold of the skin, the needle is inserted into it to the end. The needle for these purposes is better to choose a short, insulin. The injection site must be treated with a cotton swab dipped in an alcohol solution.

Permissible doses of drugs with HCG.

The volumes of chorionic gonadotropin may be different. The following dosages of the hormone are found in the pharmacy network: 500 units, 1000 units, 1500 units, 5000 units, 10000 units.

Dosages at different problems an obstetrician-gynecologist may prescribe the following.

The dosage of injections of chorionic gonadotropin, which is prescribed to maintain pregnancy, can be from 5000 IU to 10000 IU. Each time it will depend on how much of the hormone was detected in the blood of the pregnant woman. In addition, the size of the follicle is taken into account, since due to the injection of the drug with hCG, ovarian hyperstimulation syndrome may develop.

One of the main indications for the use of hCG injections is infertility. After ovulation stimulation, several procedures are prescribed ultrasound. At ultrasound sessions, follicle growth is monitored (up to 20-25 cm) and then hCG is injected, which triggers the ovulation mechanism. Also, the action of the hormone is directed against the regression of follicles, that is, it prevents the development follicular cyst. In order to stimulate ovulation, chorionic gonadotropin is indicated once at a dose of 5000 or 10000 units. Evaluate the effect of the injected injection after 24-36 hours using ultrasound equipment. Performing injections with hCG increases the possibility of conception many times over.

To stimulate the performance of the corpus luteum for 3-6-9 days, chorionic gonadotropin is indicated at a dose of 1500 units or CG 5000 units.

When performing superovulation as part of reproductive measures, the patient, after stimulating the growth of several follicles, is injected once with about 10,000 units of chorionic gonadotropin. The selection of the egg is carried out after 34-36 hours from the moment of CG injection.

If a threatened miscarriage is suspected, 10,000 units of the drug are first administered, after which the dose is reduced to 5,000 units, which is administered twice a week. Therapy is started before the 8th week of gestation, it can be continued up to the 14th week.

Indications for injection of hCG for pregnant women.

Pregnant women are prescribed injections with hCG with a sharp drop in the level of human chorionic gonadotropin in the blood in order to maintain pregnancy in the future. low concentration of this complex protein in the blood can be explained early diagnosis. Before prescribing hormone therapy for a pregnant woman, the doctor will once again send for analysis to confirm the lack of gonadotropin.

In situations in which the deviations of the indicator are significant from normal value, always taken into account for the week of pregnancy, and this downward deviation is more than 20%, then the course of hormone therapy is prescribed in without fail. Such a deviation in the hormone index may be evidence of anomalies, such as:

• ectopic pregnancy;
• frozen pregnancy;
• chronic placental insufficiency;
• risk of miscarriage.

Side effects of hCG shot

Side effects in women: due to the administration of the drug, ovarian hyperstimulation syndrome, hydrothorax, ascites, thromboembolism, and cysts may occur.

Other side effects from hCG are rare. It may be discomfort and sensation pulling pains in the abdomen, flatulence (gas formation in the abdomen), mood swings, excessive anxiety and fatigue. After the course of treatment is completed, such symptoms usually disappear.

List of contraindications.

Measures with the artificial administration of a hormone-containing drug are contraindicated:

• during lactation;
• at the onset of early menopause;
• at tumor process in the pituitary gland and ovaries;
• with thrombophlebitis;
• when fallopian tubes declared impassable;
• when allergic reactions for the drug
• with diseases of the adrenal glands;
• with hyperthyroidism.

If there are difficulties with conceiving or carrying an embryo, the doctor will first identify the cause of this violation by prescribing an hCG test and a number of other examinations. With all the importance of chorionic gonadotropin for the processes of ovulation and for maintaining the development of the fetus, as well as with its identified shortage and for some other indications, the doctor prescribes hCG injections to artificially restore the lost balance of the amount of the hormone in the woman's body.

At the same time, one should not worry that this hCG injection will be dangerous for the health of the woman herself or for the fetus.

In most situations, it is thanks to this measure that future mother It turns out to keep and endure a healthy baby. The sooner a disorder is identified that suggests immediate medical care the higher the chances of a positive outcome.

Almost every woman who plans to get pregnant knows what hCG is. This one after the egg is fertilized. However, this does not happen with anovulation. That is, there are problems with the further occurrence, maintenance and development of pregnancy.

An hCG injection with ovulation stimulation is applied after the doctor detects a dominant follicle. The injection allows it to grow to required sizes and burst.

What is a hormone?

Chorionic gonadotropin (hCG) is specific hormone human, having in its composition such subunits as alpha and. The second has no analogues in the body, so pregnancy tests are made on its basis. It is produced in the first weeks of embryo development. Its number is growing significantly. However, from the 11th week, the concentration of the hormone may decrease.

During this period, it is necessary to monitor the peculiarities of the course of pregnancy. Jumps in the level of hCG can indicate pathologies of fetal development, the threat of miscarriage. If the amount of the hormone is insufficient, then the woman has an abortion or its onset becomes impossible.

HCG promotes the production of progesterone and estrogen. The formation of the corpus luteum depends on these hormones, proper development and attachment of the embryo to the lining of the uterus. It is he who ensures the preservation of pregnancy even before the formation of the placenta.

Indications and contraindications for the use of the drug

HCG preparations have a luteinizing gonadotropic effect. They stimulate the onset of ovulation in women. They should be used if the patient has:

• dysfunction of the gonads, provoked by improper functioning of the pituitary and hypothalamus;
• anovulatory infertility (that is, the lack of education dominant follicle and development of the ovum).
• insufficient functionality of the corpus luteum;
• habitual miscarriage;
• dysmenorrhea.

HCG injections are required for the normal formation of the placenta in a pregnant woman. Without drugs based on gonadotropins, it is impossible to stimulate ovulation and IVF.

But it is not always possible to use a medicine based on hCG. Contraindications include:

• hypersensitivity to the components of the remedy;
• early menopause;
• congenital or postoperative absence of the gonads;
• neoplasm in the pituitary gland;
• hormonally active tumors.

And also you should not give hCG injections in the presence of thrombophlebitis, hypothyroidism, lack of functionality of the adrenal glands, obstruction fallopian tubes, ovarian cancer and while breastfeeding. The medicine must be used very carefully kidney failure, bronchial asthma, migraines, pressure surges, cardiac ischemia, as well as in adolescence.

Application rules

Before proceeding with the procedure for administering hCG, you need to make sure that it is allowed. It is important to follow these rules:

• Check the degree of patency of the fallopian tubes. If there is a problem, then there is no point in carrying out the procedure. Patency can be determined using laparoscopy or other diagnostic methods.
• Determine the balance of the hormonal background. Analyzes are given on the 3rd day of the menstrual cycle. Based on the results, the dosage of stimulant drugs can be adjusted.
• Get an ultrasound. This procedure will have to be carried out many times. It is necessary to determine the ovarian reserve of a woman.
• Make a spermogram for a partner, as well as test the compatibility of a couple to conceive a child.

HCG injection 5000 units. most often used if a woman for some reason does not ovulate. This dose in most cases is enough to start the process. It must be done intramuscularly. A woman can also make an injection on her own if she knows how to do it. If this is not possible, then it is better to entrust the procedure to a specialist.

If the injection of hCG is to stimulate ovulation, then it should be done in the stomach. This method is faster and more convenient. In addition, an injection in the buttock is characterized by the fact that its soreness is more pronounced.

The distance from the navel to the injection site is about 2 cm to the left and right side. Next, you need to pinch the fold of the skin and completely insert the needle into it to the base. It should be short (preferably insulin). The hCG injection site must be disinfected.

In the case of stimulation of ovulation, ultrasound control is indispensable. It is important to monitor the size of the dominant follicle. As soon as they are as acceptable as possible, an injection of hCG is immediately given. It is he who starts the process of ovulation. The regression of the follicles is prevented, so the development of a cyst is prevented.

One injection is enough to stimulate ovulation. The effectiveness of the procedure is checked by ultrasound on the second or third day. It greatly increases the chance of getting pregnant.

Before stimulation, it is necessary to check the hormonal background of a woman. Sometimes it is enough for her to restore the menstrual cycle to undergo a simple course of treatment without the use of hCG.

Features of the stimulation process

Any interference in natural processes female body, does not go unnoticed. All procedures with hormones must be carried out with the permission and under the supervision of doctors. Before prescribing an hCG injection, the specialist must find out the following data:

• dynamics of follicle enlargement;
• features of endometrial growth.

And he is also obliged to predict when ovulation should occur. In addition to the injection to the patient, concomitant drugs can be prescribed: Puregon or Klostilbegit. After the injection, ovulation occurs no later than 36 hours. The following drugs are suitable for injection: Pregnil, Chorionic Gonadotropin. The dosage of the drug is prescribed by the doctor. The most commonly used injection of hCG is 10,000 units.

During this period, it is necessary to regularly have sexual intercourse with a partner in order to become pregnant. Sex should be done every other day. Further, there is an additional stimulation of the functionality of the corpus luteum, which at first ensures the success of pregnancy and embryo development.

How to choose the right dosage?

This question should be addressed to a doctor who has the patient's examination data and is familiar with the instructions for use. Do not use injections on your own. For the first time, 5000 units of hCG are usually prescribed. If such a dosage did not give positive effect, then it can be increased to 10,000 units, but in the next cycle.

If ovulation has occurred, which was confirmed by an ultrasound study, then the patient is shown additional stimulation of the functionality of the corpus luteum. appointed on the 3rd, 6th and 9th day after the release of the egg. The dosage in this case is minimal - no more than 5000 units.

In the presence of habitual miscarriage pregnancy, the course of treatment with the use of hCG is long - up to 14 weeks. The first dose of the drug is 10,000 units. Further, the rate is reduced. A woman is given 2 injections per week of 5000 units.

Possible side effects

After stimulation has been carried out, it is important to ensure that ovulation occurs. Sometimes the patient may experience ovarian hyperstimulation syndrome. The follicle simply cannot rupture and develops into a cyst. In addition, the introduction of hCG can cause other side effects:

• disorders of the digestive tract (diarrhea, constipation, nausea);
• thromboembolism (blockage of blood vessels by a detached thrombus);
• hydrothorax (accumulation of fluid in pleural cavity, which is non-infectious);
• gynecomastia (this symptom is typical for men and manifests itself in an increase in the mammary glands);
• increased sensitivity of the nipples.

Also, the patient may have pain, as well as a rash in the area of ​​hCG injection. And also there is discomfort in the mammary glands, fever. However, after cessation of stimulation, all discomfort disappear.

Overdose and special instructions for the use of hCG

An overdose of hCG may be accompanied by ovarian hyperstimulation syndrome, which negatively affects general health women. That is, the patient has an excessive number of follicles, which eventually degenerate into cysts. Treatment of all side effects is symptomatic.

It is important to remember that long-term use of hCG-based drugs is fraught with formation. Increases the likelihood of multiple embryos (development of multiple pregnancy). During treatment, as well as within a week after its completion, pregnancy tests may show an erroneous result.

If there have already been several unsuccessful stimulation attempts, in which the dosage of the drugs used was gradually increased, then it is necessary to stop the process and undergo additional tests. After that, the methods of therapy are reviewed.

If Clostilbegit is used for stimulation, it is recommended to use it no more than 5-6 times in a lifetime. Otherwise, ovarian failure syndrome will occur and the woman will not be able to use her own eggs even for artificial insemination.

If stimulation did not give the expected result and pregnancy did not occur, do not give up. Perhaps the long-awaited conception will come after 2-3 months naturally. Moreover, now there are new reproductive technologies that allow a woman to become a mother.