CHILDREN'S PANADOL
Registration number:
P No. 011292/01Trade proprietary name: CHILDREN'S PANADOL
International non-proprietary name:
paracetamolDosage form:
oral suspensionComposition. Each 5 ml of suspension contains: active ingredient - paracetamol 120 mg; Inactive Ingredients: Malic Acid, Xantham Gum, Glucose Syrup Hydrogenate (Maltitol), Sorbitol, Citric Acid, Sodium Nipasept, Strawberry Flavor, Azorubin, Water.
Children's Panadol does not contain sugar, alcohol and acetylsalicylic acid.
Description:
A pink viscous liquid with a strawberry smell, in which crystals are present.
Pharmacotherapeutic group:
Analgesic non-narcotic drug.ATX code: N02BE01.
Pharmacological properties:
Pharmacodynamics.
The drug has analgesic and antipyretic properties. Blocks cyclooxygenase in the central nervous system, affecting the centers of pain and thermoregulation. The anti-inflammatory effect is practically absent. Does not affect the state of the mucous membrane gastrointestinal tract and water-salt metabolism, since it does not affect the synthesis of prostaglandins in peripheral tissues.
Pharmacokinetics.
High absorption - Panadol is rapidly and almost completely absorbed from the gastrointestinal tract. The connection with plasma proteins is about 15%. The peak plasma concentration is reached after 30-60 minutes. The distribution of paracetamol in body fluids is relatively even.
It is metabolized mainly in the liver with the formation of several metabolites. In newborns of the first two days of life and in children 3-10 years old, the main metabolite of paracetamol is paracetamol sulfate, in children 12 years and older - conjugated glucuronide. Part of the drug (approximately 17%) undergoes hydroxylation with the formation of active metabolites, which are conjugated with glutathione. With a lack of glutathione, these paracetamol metabolites can block the enzyme systems of hepatocytes and cause their necrosis.
The half-life when taking a therapeutic dose ranges from 2-3 hours. When taking therapeutic doses, 90-100% of the dose taken is excreted in the urine within one day. The main amount of the drug is excreted after conjugation in the liver. No more than 3% of the received dose of paracetamol is released unchanged.
Indications for use.
Used in children from 3 months to 12 years old as:
- antipyretic - to reduce fever in the background colds, flu and children infectious diseases(chickenpox, mumps, measles, rubella, scarlet fever, etc.)
- anesthetic - for toothache, including teething, headache, ear pain with otitis media and with a sore throat.
For children 2 to 3 months of age, a single dose is possible to lower the temperature after vaccination. If the temperature does not decrease, a doctor's consultation is necessary.
Contraindications:
- hypersensitivity to paracetamol or any other ingredient in the drug;
- severe liver or kidney dysfunction;
- neonatal period;
Precautionary measures:
Use with caution in case of impaired liver function (including Gilbert's syndrome), kidney, genetic absence of the enzyme glucose-6-phosphate dehydrogenase, serious illnesses blood (severe anemia, leukopenia, thrombocytopenia). In such cases, you should consult your doctor before taking the drug. The drug should not be taken simultaneously with other paracetamol-containing drugs.
Method of administration and dosage:
The drug is taken orally.Shake well before use. A measuring syringe inserted inside the package allows you to correctly and efficiently dispense the drug.
The dose of the drug depends on the age and body weight of the child.
For children over 3 months of age, a single dose is 15 mg / kg of body weight, 3-4 times a day, the maximum daily dose is no more than 60 mg / kg of body weight. Give your child the recommended dose every 4-6 hours as needed, but no more than 4 doses in 24 hours.
In all other cases, before taking Children's Panadola consultation with a doctor is required.
| Body weight (kg) | Age | Dose | |||
| One-time | Maximum daily | ||||
| ml | mg | ml | mg | ||
| 4,5-6 | 2nd month of life | Only as directed by a doctor | |||
| 6-8 | 3 - 6 months | 4.0 | 96 | 16 | 384 |
| 8-10 | 6-12 months | 5.0 | 120 | 20 | 480 |
| 10-13 | 1 - 2 years | 7.0 | 168 | 28 | 672 |
| 13-15 | 2 - 3 years | 9.0 | 216 | 36 | 864 |
| 15-21 | 36 years | 10.0 | 240 | 40 | 960 |
| 21 -29 | 6 - 9 years old | 14.0 | 336 | 56 | 1344 |
| 29-42 | 9-12 years old | 20.0 | 480 | 80 | 1920 |
Duration of admission without consulting a doctor:
- To reduce the temperature - no more than 3 days.
- For pain relief - no more than 5 days.
Side effects:
In the recommended doses, paracetamol rarely has side effects. Sometimes nausea, vomiting, pain in the stomach, allergic reactions ( skin rash, itching, urticaria, Quincke's edema). Rarely - anemia, thrombocytopenia, leukopenia.
If any adverse reactions occur, stop taking the drug immediately and consult a doctor.
Overdose:
Signs acute poisoning paracetamol are nausea, vomiting, stomach pain, sweating, pallor skin... After 1-2 days, signs of liver damage are determined (soreness in the liver, increased activity of liver enzymes). V severe cases liver failure, encephalopathy and coma develop. With prolonged use in excess of the recommended dose, hepatotoxic and nephrotoxic effects (renal colic, nonspecific bacteriuria, interstitial nephritis, papillary necrosis).Treatment: Stop using the drug and consult a doctor immediately.
Recommended gastric lavage and intake of enterosorbents ( Activated carbon, polyphepan) Acetylcysteine is a specific antidote for paracetamol poisoning.
In case of accidental overdose, you should immediately seek medical care even if the child is doing well.
Interaction with other medicinal products:
When using Children's Panadol together with barbiturates, diphenin, anticonvulsants, rifampicin, butadione may increase the risk of hepatotoxic action.
At simultaneous reception with chloramphenicol (chloramphenicol), the toxicity of the latter may increase. The anticoagulant effect of warfarin and other coumarin derivatives can be enhanced by long-term regular use of paracetamol, which increases the risk of bleeding.
Special instructions:
Children from 2 to 3 months and children born prematurely Baby Panadol can only be given as directed by a doctor. When conducting analyzes to determine uric acid and blood sugar, tell your doctor about the use of Baby Panadol.Release form:
Suspension 120 mg / 5 ml in dark glass vials of 100, 300 and 1000 ml. Vials of 100 and 300 ml together with a measuring syringe and instructions for use are packed in a cardboard boxStorage conditions:
At a temperature not exceeding 30 ° C. Protect from light. Do not freeze. Keep out of the reach of children.Shelf life:
3 years. Do not use after the expiration date stated on the package.Terms of dispensing from pharmacies:
Over the counter.Manufacturer:
GlaxoSmithKline Consumer Healthcare, manufactured by Glaxo Wellcome Production, France.Glaxo Wellcome Production, 440 Avenue du General de Gaulle, 14200 Herouville Saint Clair, France
Glaxo Wellcome Production, 440 Avenue General de Julle, 14200 Hérouville Saint Clair, France
Representative office address: 119180 Moscow, Yakimanskaya emb. 2 ZAO GlaxoSmithKline Healthcare
Composition and form of release
1 coated tablet contains paracetamol 500 mg; in a blister 12 pcs., in a box 1 blister.
1 soluble tablet - 500 mg; in a laminated strip 2 pcs., in a box 6 strips.
pharmachologic effect
pharmachologic effect- antipyretic, analgesic.Suppresses the synthesis of PG in the central nervous system, reduces the excitability of the hypothalamic center of heat regulation, increases heat transfer.
Pharmacodynamics
Has analgesic and antipyretic properties; the latter are manifested in conditions of a febrile syndrome of any genesis.
Pharmacokinetics
It is rapidly and almost completely absorbed from the gastrointestinal tract. The concentration in plasma reaches a peak in 30-60 minutes, T 1/2 of plasma - 1-4 hours. It is metabolized in the liver. Excreted in the urine, mainly in the form of esters with glucuronic and sulfuric acids; less than 5% is excreted unchanged.
Indications for Panadol ®
Mild to moderate pain ( headache, migraine, back pain, arthralgia, myalgia, neuralgia, toothache, menalgia). Feverish syndrome with colds.
Contraindications
Hypersensitivity.
Side effects
Allergic reactions in the form of skin rashes.
Interaction
Enhances the effect of indirect anticoagulants (coumarin derivatives). Metoclopramide or domperidone increase, and cholestyramine decreases the rate of absorption.
Method of administration and dosage
Inside, adults- 2 tables. up to 4 times a day with an interval between doses of at least 4 hours (the maximum daily dose is 8 tablets), children from 6 to 12 years old- 1 / 2-1 tab. up to 4 times a day with an interval between doses of at least 4 hours (the maximum daily dose is 4 tablets). Soluble tablets before taking, dissolve in 1/2 glass of water.
Overdose
Overdose symptoms in the first 24 hours - pallor, nausea, vomiting and pain in abdominal area... 12-48 hours after ingestion, kidney and liver damage may occur with the development of liver failure(encephalopathy, coma, death). Liver damage is possible when taking 10 g or more (in adults). Sharp renal failure with tubular necrosis can develop in the absence of serious damage liver. Other manifestations of overdose are cardiac arrhythmias and pancreatitis. Treatment is with oral methionine or intravenous administration of N-acetylcysteine.
Precautionary measures
It is not recommended to combine with other medications, which include paracetamol, to give to children under 6 years of age. Caution should be exercised in severe liver or kidney dysfunctions. Alcohol intake must be excluded during treatment.
special instructions
The risk of overdose increases in patients with alcoholic liver diseases of a non-cirrhotic nature.
Storage conditions of the drug Panadol ®
At a temperature not exceeding 25 ° C.Keep out of the reach of children.
Shelf life of Panadol ®
film-coated tablets 500 mg - 5 years.
soluble tablets 500 mg - 4 years.
Do not use after the expiration date printed on the package.
Synonyms for nosological groups
| ICD-10 heading | Synonyms of diseases according to ICD-10 |
|---|---|
| G43 Migraine | Migraine pain |
| Hemicrania | |
| Hemiplegic migraine | |
| Migraine headache | |
| Migraine | |
| Migraine attack | |
| Serial headache | |
| K13.7 Other and unspecified disorders of oral mucosa | Aspirin burn of the oral mucosa |
| Sore gums when wearing dentures | |
| Inflammation of the oral cavity | |
| Inflammation of the oral mucosa | |
| Inflammation of the oral mucosa after radiation therapy | |
| Inflammation of the oral mucosa after chemotherapy | |
| Inflammation of the oral mucosa | |
| Inflammation of the mucous membranes of the mouth | |
| Inflammatory diseases of the oral cavity | |
| Inflammatory process of the pharynx | |
| Disease of the oral mucosa | |
| Radioepithelitis | |
| Irritation from dentures | |
| Irritation of the oral mucosa with dentures and braces | |
| Oral cavity wounds | |
| Wounds when wearing dentures | |
| Oral and laryngeal injuries | |
| Injuries to the oral mucosa | |
| Trophic diseases of the oral mucosa | |
| Trophic diseases of the oral mucosa | |
| Erosive and ulcerative periodontal disease | |
| Erosive and ulcerative lesions of the oral mucosa | |
| Erosive and ulcerative periodontal lesions | |
| Erosive and ulcerative lesions of the oral mucosa | |
| Erosion of the oral mucosa | |
| M25.5 Joint pain | Arthralgia |
| Pain syndrome in osteoarthritis | |
| Pain syndrome in osteoarthritis | |
| Pain syndrome in acute inflammatory diseases musculoskeletal system | |
| Painful sensations in the joints | |
| Sore joints | |
| Joint soreness during heavy physical exertion | |
| Painful inflammatory lesions joints | |
| Painful conditions of the joints | |
| Painful traumatic lesions joints | |
| Shoulder pain | |
| Joint pain | |
| Joint pain | |
| Joint pain due to injuries | |
| Musculoskeletal pain | |
| Osteoarthritis pain | |
| Pain with joint pathology | |
| Pain in rheumatoid arthritis | |
| Pain in chronic degenerative bone disease | |
| Pain in chronic degenerative joint diseases | |
| Osteoarticular pain | |
| Rheumatic pain | |
| Rheumatic pains | |
| Joint pain | |
| Joint pain of rheumatic origin | |
| Joint pain syndrome | |
| Joint pain | |
| M54.3 Sciatica | Sciatica |
| Sciatic nerve neuralgia | |
| Sciatic nerve neuritis | |
| M79.1 Myalgia | Pain syndrome in musculoskeletal diseases |
| Pain syndrome in chronic inflammatory diseases of the musculoskeletal system | |
| Painful sensations in the muscles | |
| Muscle soreness | |
| Muscle soreness during heavy physical exertion | |
| Painful conditions of the musculoskeletal system | |
| Musculoskeletal pain | |
| Muscle aches | |
| Resting pain | |
| Muscle aches | |
| Muscle pain | |
| Musculoskeletal pain | |
| Myalgia | |
| Myofascial pain syndromes | |
| Muscle pain | |
| Muscle pain at rest | |
| Muscle pain | |
| Muscle pains of non-rheumatic origin | |
| Muscle pains of rheumatic origin | |
| Acute muscle pain | |
| Rheumatic pain | |
| Rheumatic pains | |
| Myofascial syndrome | |
| Fibromyalgia | |
| M79.2 Neuralgia and neuritis, unspecified | |
| Brachialgia | |
| Occipital and intercostal neuralgia | |
| Neuralgia | |
| Neuralgic pains | |
| Neuralgia | |
| Intercostal nerve neuralgia | |
| Posterior tibial nerve neuralgia | |
| Neuritis | |
| Traumatic neuritis | |
| Neuritis | |
| Neurological pain syndromes | |
| Neurological contractures with spasms | |
| Acute neuritis | |
| Peripheral neuritis | |
| Post-traumatic neuralgia | |
| Severe neurogenic pain | |
| Chronic neuritis | |
| Essential neuralgia | |
| N94.6 Dysmenorrhea, unspecified | Algodismenorrhea |
| Algomenorrhea | |
| Pain syndrome with spasms of smooth muscles | |
| Pain syndrome with spasms of smooth muscles (renal and biliary colic, intestinal spasm, dysmenorrhea) | |
| Pain syndrome with spasms of smooth muscles internal organs | |
| Pain syndrome with spasms of smooth muscles of internal organs (renal and biliary colic, intestinal spasm, dysmenorrhea) | |
| Painful sensations during menstruation | |
| Painful irregular periods | |
| Pain during menstruation | |
| Pain during menstruation | |
| Dysalgomenorrhea | |
| Dysmenorrhea | |
| Dysmenorrhea (essential) (exfoliative) | |
| Menstrual disorder | |
| Menstrual crumbs | |
| Menses painful | |
| Metrorrhagia | |
| Disruption of the menstrual cycle | |
| Menstrual irregularities | |
| Primary dysalgomenorrhea | |
| Prolactin-dependent menstrual irregularities | |
| Prolactin-dependent menstrual dysfunction | |
| Menstrual disorder | |
| Spasmodic dysmenorrhea | |
| Functional disorders of the menstrual cycle | |
| Functional disorders of the menstrual cycle | |
| R50 Fever of unknown origin | Hyperthermia, malignant |
| Malignant hyperthermia | |
| R51 Headache | Headache |
| Pain with sinusitis | |
| Back pain | |
| Headache | |
| Headache of vasomotor genesis | |
| Headache of vasomotor origin | |
| Headache with vasomotor disorders | |
| Headache | |
| Neurological headache | |
| Serial headache | |
| Cephalalgia | |
| R52 Pain, not elsewhere classified | Radicular pain syndrome |
| Pain syndrome of low and medium intensity of various origins | |
| Pain syndrome after orthopedic surgery | |
| Pain syndrome in superficial pathological processes | |
| Radicular pain against the background of osteochondrosis of the spine | |
| Radicular pain syndrome | |
| Pleural pain | |
| Chronic pain | |
| R52.2 Other constant pain | Pain syndrome of non-rheumatic origin |
| Pain syndrome with vertebral lesions | |
| Pain syndrome with neuralgia | |
| Pain syndrome with burns | |
| Pain syndrome is weak or moderate | |
| Neuropathic pain | |
| Neuropathic pain | |
| Perioperative pain | |
| Moderate to severe pain | |
| Moderate or mild pain syndrome | |
| Moderate to severe pain syndrome | |
| Ear pain with otitis media |
Self-medication can be harmful to your health.
It is necessary to consult a doctor and read the instructions before use.
Panadol: instructions for use
Composition
Each tablet contains 500 mg of paracetamol.
Excipients: pregelatinized starch, corn starch, povidone, potassium sorbate, talc, stearic acid, water, hydroxypropyl methyl cellulose, triacetin.
Description
White capsule-shaped tablets with a flat edge. On one side of the tablet there is an embossed PANADOL, on the other side - a risk.
pharmachologic effect
Pharmacotherapeutic group: analgesic non-narcotic agent.
ATX code: N02BE01.
Pharmacological properties: The drug has analgesic and antipyretic properties. Blocks cyclooxygenase in the central nervous system, affecting the centers of pain and thermoregulation. The anti-inflammatory effect is practically absent. Does not irritate the gastric and intestinal mucosa. It does not affect water-salt metabolism, since it does not affect the synthesis of prostaglandins in peripheral tissues.
Indications for use
1. Pain syndrome. For headache, migraine, toothache, sore throat, back pain, muscle pain, painful periods.
2. Febrile syndrome as an antipyretic agent. At elevated temperatures against the background of "colds" diseases and flu.
Contraindications
Hypersensitivity to paracetamol or any other ingredient in the drug;
Severe liver or kidney dysfunction;
Contraindicated in children under 9 years of age and weighing less than 35 kilograms.
Method of administration and dosage
Adults (including the elderly): 0.5 - 1 g (1-2 tablets) up to 4 times a day, if necessary. The interval between doses is at least 4 hours, a single dose (2 tablets) can be taken no more than 4 times (8 tablets) within 24 hours.
Children (9-12 years old): 1 tablet up to 4 times daily as needed. The interval between doses is at least 4 hours, a single dose (1 tablet) can be taken no more than 4 times (4 tablets) within 24 hours.
The drug is not recommended to be used for more than 5 days as an anesthetic and more than 3 days as an antipyretic agent without the appointment and supervision of a doctor. An increase in the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.
Do not exceed the indicated dose. In case of overdose, see your doctor immediately, even if you feel well.
Side effect
In the recommended doses, the drug is usually well tolerated. Paracetamol rarely causes side effects... Sometimes there may be an allergic reaction in the form of skin rashes, itching, Quincke's edema. Rarely - disorders of the blood system (anemia, thrombocytopenia, methemoglobinemia).
With prolonged use in high doses, the likelihood of impaired liver and kidney function (renal colic, nonspecific bacteriuria, interstitial nephritis, papillary necrosis) increases and blood picture monitoring is necessary. If you experience unusual symptoms, you should see a doctor.
Overdose
Signs of acute paracetamol poisoning are nausea, vomiting, stomach pain, sweating, pallor of the skin. After 1-2 days, signs of liver damage are determined (soreness in the liver, increased activity of "liver" enzymes). In severe cases, liver failure, encephalopathy and coma develop.
Treatment: Stop using the drug and consult a doctor immediately.
In case of accidental overdose, you should immediately seek medical attention, even if you feel well.
Interaction with other medicinal products
Interaction with other medicinal products: the drug, when taken for a long time, enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding. Inducers of microsomal oxidation enzymes in the liver (barbiturates, diphenin, carbamazepine, rifampicin, zidovudine, phenytoin, ethanol, flumecinol, phenylbutazone, and tricyclic antidepressants) increase the risk of hepatotoxic effects in overdose. Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxic effects.
Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol. Ethanol contributes to the development of acute pancreatitis. The drug can reduce the activity of uricosuric drugs.
Application features
Before taking the drug, you should consult your doctor if:
You have liver or kidney disease;
You are taking drugs for nausea and vomiting (metoclopramide, domperidone) and drugs that lower blood cholesterol (cholestyramine);
You are taking anticoagulants and you need pain relievers every day for a long time. Paracetamol in this case can be taken occasionally;
You are pregnant or breastfeeding.
PERSONS WITH ALCOHOL ABUSE SHOULD CONSULT A DOCTOR BEFORE TAKING THE MEDICINE. IN THE CASE OF EXCEEDING THE RECOMMENDED DOSE, PARACETAMOL MAY BE LIVER DAMAGING.
Precautionary measures
Use with caution in benign hyperbilirubinemia (including Gilbert's syndrome), viral hepatitis, alcoholic injury liver, deficiency of glucose-6-phosphate dehydrogenase, alcoholism, pregnancy, lactation. The drug should not be taken simultaneously with other paracetamol-containing drugs.
Release form
1 or 2 blisters (6 or 12 tablets each) are packed in a cardboard box with instructions for use.
Storage conditions
At a temperature not exceeding 25 ° C, out of the reach of children.
Panadol
Latin name: Panadol
Pharmacological groups:
pharmachologic effect
Application:
Contraindications:
Side effects:
Interaction:
Overdose:Symptoms:
Treatment:
Method of administration and dosage:
Precautionary measures:
- Panadol
Panadol asset
Latin name: Panadol active
Pharmacological groups: Non-narcotic analgesics, including non-steroidal and other anti-inflammatory drugs
Nosological classification (ICD-10): A38 Scarlet fever. B01 Chicken pox... B05 Measles. B26 Parotitis... G43 Migraine. H66 Purulent and unspecified otitis media... J00-J06 Acute upper respiratory infections respiratory tract... J03 Acute tonsillitis [tonsillitis]. J10-J18 Influenza and pneumonia. J11 Influenza, virus not identified. K00.7 Teething syndrome K08.8.0 Toothache K13.7 Other and unspecified disorders of oral mucosa M25.5 Joint pain M54.3 Sciatica M79.1 Myalgia M79.2 Neuralgia and neuritis, unspecified N94.6 Dysmenorrhea, unspecified R07.0 Sore throat. R50 Fever of unknown origin. R51 Headache. R52 Pain, not elsewhere classified. R52.2 Other persistent pain. T08-T14 Injuries to unspecified part of trunk, limb or body region. T14 Injury, unspecified. T20-T32 Thermal and chemical burns... Z100 CLASS XXII Surgical practice. Z29.1 Prophylactic immunotherapy
pharmachologic effect
Active ingredient (INN) Paracetamol (Paracetamol)
Application: Pain of mild and moderate intensity (headache and toothache, migraine, back pain, arthralgia, myalgia, neuralgia, menalgia), febrile syndrome with colds.
Contraindications: Hypersensitivity, impaired renal and liver function, alcoholism, childhood(up to 6 years old).
Side effects: Agranulocytosis, thrombocytopenia, anemia, renal colic, aseptic pyuria, interstitial glomerulonephritis, allergic reactions in the form of skin rashes.
Interaction: Increases the effect of indirect anticoagulants (coumarin derivatives) and the likelihood of liver damage by hepatotoxic drugs. Metoclopramide increases and cholestyramine decreases the rate of absorption. Barbiturates reduce antipyretic activity.
Overdose:Symptoms: in the first 24 hours - pallor, nausea, vomiting and pain in the abdominal region; 12–48 hours later - damage to the kidneys and liver with the development of liver failure (encephalopathy, coma, death), cardiac arrhythmias and pancreatitis. Liver damage is possible when taking 10 g or more (in adults).
Treatment: the appointment of methionine by mouth or intravenous administration of N-acetylcysteine.
Method of administration and dosage: Inside and rectally, adults and children over 12 years old, 0.5-1 g up to 4 times a day; the maximum daily dose is 4 g, the course of treatment is 5-7 days. Children 6–12 years old - 240–480 mg, 1–6 years old - 120–240 mg, from 3 months to 1 year - 24–120 mg up to 4 times a day for 3 days. Soluble tablets are dissolved in 1/2 glass of water before taking.
Precautionary measures: The risk of overdose increases in patients with alcoholic liver diseases of a non-cirrhotic nature.
- Panadol active
Panadol tablets soluble
Latin name: Panadol soluble
Pharmacological groups: Non-narcotic analgesics, including non-steroidal and other anti-inflammatory drugs
Nosological classification (ICD-10): A38 Scarlet fever. B01 Chickenpox. B05 Measles. B26 Mumps. G43 Migraine. H66 Purulent and unspecified otitis media. J00-J06 Acute upper respiratory tract infections. J03 Acute tonsillitis [tonsillitis]. J10-J18 Influenza and pneumonia. J11 Influenza, virus not identified. K00.7 Teething syndrome K08.8.0 Toothache K13.7 Other and unspecified disorders of oral mucosa M25.5 Joint pain M54.3 Sciatica M79.1 Myalgia M79.2 Neuralgia and neuritis, unspecified N94.6 Dysmenorrhea, unspecified R07.0 Sore throat. R50 Fever of unknown origin. R51 Headache. R52 Pain, not elsewhere classified. R52.2 Other persistent pain. T08-T14 Injuries to unspecified part of trunk, limb or body region. T14 Injury, unspecified. T20-T32 Thermal and chemical burns. Z100 CLASS XXII Surgical practice. Z29.1 Prophylactic immunotherapy
pharmachologic effect
Active ingredient (INN) Paracetamol (Paracetamol)
Application: Pain of mild and moderate intensity (headache and toothache, migraine, back pain, arthralgia, myalgia, neuralgia, menalgia), febrile syndrome with colds.
Contraindications: Hypersensitivity, impaired renal and liver function, alcoholism, childhood (up to 6 years).
Side effects: Agranulocytosis, thrombocytopenia, anemia, renal colic, aseptic pyuria, interstitial glomerulonephritis, allergic reactions in the form of skin rashes.
Interaction: Increases the effect of indirect anticoagulants (coumarin derivatives) and the likelihood of liver damage by hepatotoxic drugs. Metoclopramide increases and cholestyramine decreases the rate of absorption. Barbiturates reduce antipyretic activity.
Overdose:Symptoms: in the first 24 hours - pallor, nausea, vomiting and pain in the abdominal region; 12–48 hours later - damage to the kidneys and liver with the development of liver failure (encephalopathy, coma, death), cardiac arrhythmias and pancreatitis. Liver damage is possible when taking 10 g or more (in adults).
Treatment: the appointment of methionine by mouth or intravenous administration of N-acetylcysteine.
Method of administration and dosage: Inside and rectally, adults and children over 12 years old, 0.5-1 g up to 4 times a day; the maximum daily dose is 4 g, the course of treatment is 5-7 days. Children 6–12 years old - 240–480 mg, 1–6 years old - 120–240 mg, from 3 months to 1 year - 24–120 mg up to 4 times a day for 3 days. Soluble tablets are dissolved in 1/2 glass of water before taking.
Precautionary measures: The risk of overdose increases in patients with alcoholic liver diseases of a non-cirrhotic nature.
- Panadol soluble tablets (Panadol soluble)
Active ingredient (INN) Pinaverium bromide (Pinaverium bromide)
Application:
Contraindications: Hypersensitivity.
Restrictions on use:
Side effects:
Method of administration and dosage:Inside
Special instructions:
- Pinaverium bromide (-)
Dicetel
Latin name: Dicetel
Pharmacological groups: Myotropic antispasmodics
Nosological classification (ICD-10): K58 Irritable bowel syndrome K82.8.0 Dyskinesia of gallbladder and biliary tract... K94 Diagnosis of gastrointestinal diseases
pharmachologic effect
Active ingredient (INN) Pinaverium bromide (Pinaverium bromide)
Application: Organ smooth muscle spasms abdominal cavity: colon dyskinesia, biliary dyskinesia; preparation for X-ray examination of the gastrointestinal tract using barium (Instructions for medical use drug Dicetel. Approved by the Pharmacological Committee of the Ministry of Health of the Russian Federation on July 18, 2002, pr. No. 4p).
Symptomatic treatment pain syndrome with gastrointestinal dyskinesia, irritable bowel syndrome; preparation for X-ray examination of the gastrointestinal tract with contrast (Federal guidelines for the use of drugs (formulary system), issue V, 2004).
Cholecystitis, cholangitis, gastritis, duodenitis, esophagitis, enteritis, pylorospasm, cholelithiasis, intestinal colic, biliary colic, renal colic, biliary dyskinesia, spastic colitis, gastralgia; postcholecystectomy syndrome, irritable syndrome small intestine... Preparation for endoscopic and X-ray studies of the gastrointestinal tract (State Register of Medicines, vol. 2, 2000).
Contraindications: Hypersensitivity.
Restrictions on use: Pregnancy, breastfeeding, childhood.
Side effects: Dyspeptic symptoms, nausea, constipation, allergic reactions.
Method of administration and dosage:Inside, while eating, drinking plenty of water without breaking, chewing or dissolving. Adults - 50 mg 3-4 times a day (up to 300 mg / day, no more). In preparation for a barium enema - 200 mg / day daily for 3 days preceding the procedure.
Special instructions: Do not take tablets before lying down or just before bed.
- Dicetel
Proproten-100
Latin name: Proproten-100
Pharmacological groups: Means for correcting disorders in alcoholism, toxic and drug addiction
Nosological classification (ICD-10): F10.2 Syndrome alcohol addiction... F10.3 Withdrawal state
:
APPROVED
Head of the Department of State Control of Medicines, Products medical purpose and medical equipment of the Ministry of Health of the Russian Federation.
Approved by the Pharmacological Committee of the Ministry of Health of the Russian Federation on March 13, 2003.
INSTRUCTIONS for medical use of the drug PROPROTEN-100 (Proproten-100)
Description.
Complex homeopathic remedy... Tablets from white to white with cream or white with a grayish shade, flat-cylindrical shape with a beveled and scored, with a smooth, uniform surface.
Composition.
Antibodies to brain-specific protein S-100 affinity purified C1000.
Excipients: microcrystalline cellulose, calcium stearate or magnesium stearate, lactose.
Pharmacological properties.
Relieves mental disorders (agitation, irritability, anxiety, depression, insomnia, attraction to alcoholic beverages), neurological (tremor, headache) and somatic (sweating, tachycardia, arterial hypertension, digestive disorders) manifestations of alcohol withdrawal syndrome.
Indications.
- Alcohol withdrawal syndrome of mild and moderate severity.
- Prevention of relapse of alcoholism.
Contraindications
Not found.
Side effects.
Isolated cases of short-term (5-10 minutes) violation of accommodation.
Interaction.
Compatible with other pharmaceuticals.
Method of administration and dosage.
Dissolve the tablet in the mouth 15–20 minutes before meals. In the first 2 hours take 1 table. every 30 minutes, in the next 8-10 hours- 1 table. in hour. In case of sleep onset, Proproten-100 should be resumed upon awakening.
Further, when the condition improves, the drug is prescribed in 1 table. every 2-3 hours (4-6 tablets per day).
When the symptoms of alcohol withdrawal are aggravated, traditionally used drugs must be added to the therapy with Proproten-100.
For the prevention of relapses, incl. reducing the pathological craving for alcohol should be taken in 1–2 table. per day for 2-3 months.
Release form.
In polymer cans of 20 or 50 pcs., In a cardboard box 1 can.
In dark glass bottles of 25 ml, in a cardboard box 1 bottle.
Storage conditions.
Store in a dry, dark place, out of the reach of children, at a temperature not exceeding 25 ° C.
Shelf life.
3 years.
Conditions for dispensing from pharmacies.
Over the counter
- Proproten-100 (Proproten-100)
Reamberin
Latin name: Reamberinum
Pharmacological groups: Detoxifying agents, including antidotes. Regulators of water-electrolyte balance and acid-base balance
Nosological classification (ICD-10): A48.3 Toxic shock syndrome
:
INSTRUCTIONS FOR USE
APPROVED by the Federal Committee of the Ministry of Health of the Russian Federation on May 24, 2001, pr. No. 7.
Composition. Reamberin 1.5% balanced isotonic detoxifying infusion solution containing N- (1-deoxy-D-glucitol-1-yl) -N-methylammonium, sodium succinate (1.5%), sodium chloride (0.6%), potassium chloride (0.03%), magnesium chloride (0.012%), water for injection up to 1 liter.
Pharmacological properties. Reamberin has antihypoxic and antioxidant effects, providing positive effect on aerobic processes in the cell, reducing the production of free radicals and restoring energy potential cells.
The drug activates the enzymatic processes of the Krebs cycle and promotes utilization fatty acids and glucose by cells, normalizes acid-base balance and blood gas composition.
It has a moderate diuretic effect.
Indications for use. Reamberin 1.5% is used in children and adults as an antihypoxic and detoxifying agent in acute intoxication different etiology.
Contraindications Individual intolerance. Condition after TBI, accompanied by cerebral edema, severe renal dysfunction, pregnancy.
Method of administration and dosage. Reamberin is administered to adults up to 800 ml per day only by intravenous drip at a rate of no more than 90 drops / min (4-4.5 ml / min). Depending on the severity of the disease, the course of administration of the drug is up to 11 days.
Children are injected intravenously at the rate of 10 ml / kg of body weight daily 1 time per day.
Side effect. With the rapid introduction of the drug, short-term reactions are possible in the form of a feeling of heat and redness of the upper body.
Special instructions. Due to the activation of aerobic processes in the body by the drug, a decrease in the concentration of glucose in the blood and alkalization of blood and urine are possible.
Release form. Solution in bottles of 200 and 400 ml. The bottle is packed in a cardboard box.
Storage conditions. The drug should be stored in a dry, dark place under normal conditions. Freezing during transportation is allowed. If the color of the solution changes or there is a sediment, the use of the drug is unacceptable. Keep out of the reach of children.
Shelf life 3 years.
Conditions for dispensing from pharmacies. Prescribed by a doctor.
- Reamberin (Reamberinum)
Kanglight
Latin name: Kanglaite
Pharmacological groups: Antineoplastic agents vegetable origin
INSTRUCTIONS FOR USE
APPROVED by the Federal Committee of the Ministry of Health of the Russian Federation on July 24, 2003, pr. No. 6p.
Composition. 1 ml of emulsion contains:
active substance: Coix seed oil for injection 100 mg.
Excipients: soy lecithin, glycerin, water for injection.
Description. White oil-in-water emulsion.
Characteristic. The preparation obtained by the extraction of natural active ingredient from seeds of Coix (Coix lacryma-jobi L. Var. Ma-yuen (Roman) Stapf, Fem. Gramineae).
Pharmacodynamics. Antineoplastic drug. The antitumor effect of Kanglite is due to inhibition of the mitosis of tumor cells, the induction of their apoptosis and the effect on the expression of tumor cells.
Indications for use. Non-small cell lung cancer.
Contraindications Severe violation lipid metabolism (shock, acute pancreatitis, hyperlipidemia, lipoid nephrosis), pregnancy, period breastfeeding, increased individual sensitivity to the drug.
Method of administration and dosage. The usual dose of the drug is 20 g (200 ml) daily as a slow intravenous infusion for 21 days. The break between courses of treatment should be 3-5 days. The treatment cycle includes 2 courses. When the drug is combined with chemotherapy and radiation therapy the dose of Kanglaite may be reduced. At the beginning of the intravenous injection, it is recommended to set the injection rate of the drug at the level of 20 drops / min during the first 10 minutes, after 20 minutes, the rate can be gradually increased, bringing to 40-60 drops / min after 30 minutes from the start of the injection.
Side effect. Allergic reactions to lipids in the form of fever, chills and mild nausea. These symptoms usually resolve within 3-5 days.
Phlebitis can sometimes occur. With extravasation - pain, irritation of the surrounding tissues.
Overdose. In case of an unintentional overdose, an increase in the above adverse reactions is usually not observed.
Interaction. Kanglite must not be mixed with other drugs (pharmaceutical incompatibility).
Special instructions. When pronounced allergic reaction treatment should be discontinued and symptomatic therapy should be prescribed.
When signs of phlebitis appear, it is recommended to administer 50-100 ml of 0.9% sodium chloride solution or 5% dextrose solution before or after intravenous administration of Kanglight.
Extravasal administration of the drug should be avoided. To reduce the local irritating effect, in case of cooling, it is recommended to heat the preparation in a water bath at a temperature of 30 ° C.
When the emulsion is stratified, the drug cannot be used.
Release form. Emulsion for intravenous infusion in vials of 10 g / 100 ml. 1 bottle in a cardboard box with attached instructions for use.
Storage conditions. Out of the reach of children and protected from light at a temperature not exceeding +25 ° C, avoiding freezing.
Shelf life. 1 year. Do not use after the expiration date printed on the package.
Conditions for dispensing from pharmacies. Prescribed by a doctor.
- Kanglaite
Ceruloplasmin lyophilized for injection 0.1 g
Latin name: Ceruloplasminum lyophilisatum pro injectionibus 0.1 g
Pharmacological groups: Detoxifying agents, including antidotes. Stimulants of hematopoiesis
:
INSTRUCTIONS FOR USE
APPROVED BY FK MH RF 10/19/1990
Characteristic. Ceruloplasmin is a copper-containing enzyme from the alpha2-globulin fraction of blood serum. Received from donor human blood plasma. V medical practice it is used in the form of a solution, which is prepared from a lyophilized blue powder.
Description. Lyophilized blue powder.
Pharmacological properties. Ceruloplasmin is the main antioxidant in the blood, the drug stimulates hematopoiesis (red sprout of hematopoiesis), reduces intoxication and immunosuppression by binding superoxide radicals and preventing lipid peroxidation of cell membranes.
Indications for use. Ceruloplasmin is used to stimulate hematopoiesis, reduce intoxication and maintain immunoreactivity in complex therapy cancer patients; during preoperative preparation, especially in debilitated patients with anemia, intoxication and exhaustion; in early postoperative period in patients with massive surgical blood loss; at purulent-septic complications in the early postoperative period; when carrying out combined chemotherapy, including in patients with hemoblastosis with mild intoxication.
The drug is also used in the complex therapy of patients with acute and chronic osteomyelitis.
Method of administration and dosage. The drug is administered i / v. The contents of 1 bottle (ampoule) are dissolved in 200 ml of 5% glucose solution or isotonic sodium chloride solution and injected at a rate of 30 drops per minute.
During preoperative preparation, ceruloplasmin is administered to cancer patients at a dose of 1.5–2 mg / kg of body weight; daily or every other day, depending on the patient's condition. The course of treatment is 7-10 injections.
In the postoperative period, a single dose is determined by the amount of blood loss and ranges from 1.5 mg / kg of body weight (with low blood loss) to 6 mg / kg of body weight (with large blood loss), daily. The course of treatment is 7-10 days.
When carrying out chemoradiation treatment, a single dose is 4–6 mg / kg of body weight, 3 times a week. The course of treatment is 10-14 injections.
In patients with hemoblastosis, a single dose is 1.5–3 mg / kg of body weight, daily. The course of treatment is 7-10 days.
If the patient receives high doses of corticosteroids and there is a risk of developing a steroid diabetes mellitus, Ceruloplasmin should be dissolved in isotonic sodium chloride solution.
In patients with acute and chronic osteomyelitis, Ceruloplasmin is used intravenously. In acute osteomyelitis, a single dose is 2.5 mg / kg of body weight, the course of treatment consists of 5 injections administered daily or every other day.
In chronic osteomyelitis, Ceruloplasmin is administered at 5 mg / kg body weight 2-3 times with an interval of 1-2 days and then 3-7 injections of 2.5 mg / kg body weight are made every other day.
Side effect. At the beginning of treatment, there may be a feeling of a rush of blood to the face, nausea, chills, a short-term increase in temperature, skin rashes (urticaria). In these cases, the dose is reduced, the rate of administration is reduced, or the drug is discontinued.
Contraindications The use of Ceruloplasmin is contraindicated in hypersensitivity to preparations of protein origin.
Release form. Ceruloplasmin is available as a lyophilized powder for injection. in vials or ampoules of 100 mg, in a cardboard box of 5 vials (ampoules).
Storage conditions. In a dry place at a temperature of +5 ° C.
Shelf life. 2 years.
Pre
- Ceruloplasmin lyophilized for injection 0.1 g (Ceruloplasminum lyophilisatum pro injectionibus 0.1 g)
Realdiron
Latin name: Realdiron
Pharmacological groups: Immunomodulators. Antiviral agents
Nosological classification (ICD-10): A84 Tick-borne viral encephalitis... B16 Acute hepatitis B. B18.1 Chronic viral hepatitis B without delta agent. B18.2 Chronic viral hepatitis C. B21.0 Disease caused by HIV, with manifestations of Kaposi's sarcoma. C43 Malignant melanoma of the skin. C64 Malignant neoplasm kidney, except for the renal pelvis. C84 Peripheral and cutaneous T-cell lymphomas. C84.0 Fungal mycosis C84.1 Cesari's disease C91.4 Hairy cell leukemia C92.1 Chronic myeloid leukemia
:
INSTRUCTIONS FOR USE
Composition. Active substance: interferon alpha-2b human recombinant.
Excipients: sodium chloride, disodium hydrogen phosphate dodecahydrate, sodium dihydrogen phosphate dihydrate.
Stabilizing agent: dextran 60.
Realdiron as sterile dry matter white in ampoules or vials available in 1, 3, 6, 9 or 18 million IU.
Pharmacological properties. Realdiron has antiviral, immunomodulatory, antiproliferative and antitumor effects.
Interferon alpha-2b human recombinant isolated from cells Pseudomonas putida, in the genetic apparatus of which the human gene is embedded leukocyte interferon alpha-2b. Polypeptide structure of the molecule, biological activity and pharmacological properties recombinant protein and human leukocyte interferon alpha-2b are identical.
Interferon alpha, interacting with related receptors on the cell surface, initiates a complex chain of changes within the cell. It is assumed that these processes are associated with the prevention of viral replication in the cell, inhibition of cell proliferation and the immunomodulatory effect of interferon. Interferon alpha has the ability to stimulate the phagocytic activity of macrophages, as well as the cytotoxic activity of T cells and natural killer cells. These properties of interferon alpha are due to curative action Realdirona.
Indications for use. Realdiron is used in patients:
For viral diseases:
- acute hepatitis B;
- chronic active hepatitis B;
- chronic hepatitis C;
- tick-borne encephalitis.
At oncological diseases:
- hairy cell leukemia;
- chronic myeloid leukemia;
- renal cell carcinoma;
- Kaposi's sarcoma against the background of AIDS;
- cutaneous T-cell lymphoma (fungal mycosis and Sesari's syndrome);
- malignant melanoma.
Method of administration and dosage. Realdiron is used for intramuscular or subcutaneous administration, dissolving immediately before use the contents of an ampoule or vial in 1 ml of water for injection. The drug dissolves quickly, regardless of the dose contained in the ampoule or vial. The drug solution may be opalescent.
Viral diseases
For acute hepatitis B (mild, moderate and severe forms)
Realdiron is administered at 1 million IU 2 times a day for 5-6 days, then the dose is reduced to 1 million IU per day and administered for another 5 days. If necessary (after control biochemical blood tests to assess functional state liver), treatment can be continued for another 2 weeks, during which the drug is administered 1 million IU 2 times a week.
Realdiron is most effective at the beginning of the icteric period up to 5 days of jaundice, more late dates prescribing the drug is less effective. Realdiron is ineffective in developing hepatic coma and cholestatic course of the disease.
For chronic active hepatitis B appoint Realdiron 3-6 million IU 3 times a week for 24 weeks. If after the administration of the drug within 12 weeks there is no clinical, biochemical improvement and / or disappearance of HBeAg, treatment with Realdiron is canceled.
For chronic hepatitis C appoint Realdiron 3 million IU 3 times a week for 24 weeks. If after the administration of the drug within 4 weeks there is no 50% decrease in the activity of ALT in the blood plasma, the dose of the drug is increased to 6 million IU 3 times a week. Treatment with Realdiron is discontinued if, after 12 weeks of using the drug, there is no clinical, biochemical improvement.
With tick-borne encephalitis Realdiron is effective for meningeal forms tick-borne encephalitis... Realdiron is administered at 1-3 million IU 2 times a day for 10 days. Then, supportive treatment is prescribed - 5 times, 1-3 million IU every 2 days.
Oncological diseases
The instructions indicate the recommended therapeutic doses of Realdiron. General principle the use of interferon for cancer is the appointment maximum dose, which can be tolerated by the patient for a sufficiently long period of time (months and years). Since interferon alpha has a cytostatic effect, maintenance treatment with Realdiron should be continued after an objective effect is achieved - hematological remission, regression of solid tumor foci.
With hairy cell leukemia Realdiron is administered at 3 million IU daily. After reaching hematological remission, they switch to maintenance therapy, 3 million IU 3 times a week.
With chronic myeloid leukemia use Realdiron 9 million IU daily. After reaching hematological remission, maintenance treatment is prescribed at 9 million IU 3 times a week.
For renal cell carcinoma Realdiron is injected at 18 million IU 3 times a week. An objective effect (complete or partial regression of metastases) appears after 8–12 weeks of treatment with Realdiron or later. Upon reaching therapeutic effect or stabilization of the disease, maintenance therapy is continued at 18 million IU 3 times a week.
With Kaposi's sarcoma on the background of AIDS Realdiron is injected daily at 36 million IU. The drug is used for a long time, except in cases of rapid progression or severe intolerance. After the manifestation of the effect, maintenance therapy is prescribed at 18 million IU 3 times a week.
For cutaneous T-cell lymphoma (fungal mycosis and Sesari's syndrome) Realdiron is prescribed 18 million IU daily.
For malignant melanoma Realdiron is administered at 18 million IU daily. After achieving an objective effect (complete or partial regression of metastases), maintenance therapy is prescribed at 18 million IU 3 times a week. Adjuvant therapy with Realdiron 18 million IU 3 times a week, prescribed after surgical removal primary tumor of stage I-II melanoma or metastases in regional The lymph nodes, helps to increase the duration of remission and survival of patients.
Side effect. With the introduction of Realdiron, flu-like symptoms are possible: most often - chills, fever, fatigue, lethargy, headache, myalgia, joint pain, loss of appetite. These symptoms are partially relieved by paracetamol. When treating with Realdiron, minor leukopenia, thrombocytopenia, some deviations in liver function indicators are possible. These adverse reactions disappear when Realdiron is canceled or its dose is reduced.
Contraindications Realdiron is not prescribed to patients with allergies to interferon alfa or other components of the drug.
Application during pregnancy and breastfeeding. Realdiron should be prescribed to pregnant women and nursing mothers only if the expected therapeutic effect in the mother is clearly superior to the possible undesirable effect on the fetus (especially in the first 3 months) or the child.
Special warnings. Patients with severe heart disease are prescribed Realdiron with caution. In patients with previous illnesses of cardio-vascular system, arrhythmia may occur as an adverse reaction.
If the side effect of the drug does not weaken or even intensifies, the dose is reduced to 50%, or treatment with Realdiron is stopped.
Depending on the individual sensitivity and the prescribed dose of treatment, patients may experience a delayed response due to manifestations side effects Realdirona in the form of drowsiness, weakness, fatigue.
When treating with Realdiron, the use of alcohol should be excluded.
Storage conditions. Realdiron should be stored at 2-8 ° C. The expiration date (3 years) is indicated on the label. Realdiron does not contain preservatives, therefore, in order to avoid bacterial contamination, it is recommended to use only a freshly prepared solution for intramuscular or subcutaneous administration.
Package. Each pack contains 5 ampoules or vials of Realdiron and instruction on the use of the drug.
Dispensing from pharmacies. Realdiron is available on prescription.
- Realdiron
Composition
1 coated tablet, Panadol contains:Paracetamol - 500mg;
Excipients.
1 coated tablet, Panadol Active contains:
Paracetamol - 500mg;
Excipients, including sodium bicarbonate.
1 tablet soluble Panadol Solubl contains:
Paracetamol - 500mg;
Excipients.
pharmachologic effect
Panadol is a drug of a group of non-selective non-steroidal anti-inflammatory drugs. The drug contains the active substance paracetamol, which has a pronounced antipyretic and analgesic effect. The mechanism of action of the drug is associated with inhibition of the synthesis of prostaglandins, which occurs due to a decrease in the activity of the enzyme cyclooxygenase. The anti-inflammatory effect of the drug is weak due to the fact that paracetamol is inactivated by cellular peroxidases. The analgesic and antipyretic effect of the drug is carried out by reducing the amount of prostaglandins in the central nervous system.In addition to paracetamol, Panadol Active contains sodium bicarbonate, which helps to accelerate absorption active substance and ensures the early onset of the therapeutic effect of paracetamol.
After oral administration paracetamol is well absorbed in the gastrointestinal tract, the maximum plasma concentration of the active substance is observed 30-120 minutes after taking the drug. The degree of association of paracetamol with plasma proteins is low. It is metabolized mainly in the liver, excreted by the kidneys in the form of metabolites. The half-life is 2-3 hours.
Indications for use
The drug is used to eliminate pain syndrome of various etiologies, including:Headache, migraine and migraine-like pain.
Myalgia, arthralgia, rheumatic pains, neuralgia.
Algodismenorrhea, toothache.
In addition, the drug can be used to relieve flu symptoms, including fever, headache, and muscle pain.
Mode of application
The drug is taken orally. Panadol and Panadol Active tablets are recommended to be swallowed whole, without chewing or crushing, drinking enough water. Before taking Panadol Solubl tablets should be dissolved in a glass of water. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient.Adults and adolescents over the age of 12 are usually prescribed 500-1000 mg of the drug 3-4 times a day. It is recommended to observe the interval between taking the drug at least 4 hours.
Children aged 6 to 12 years are usually prescribed 250-500 mg of the drug 3-4 times a day. It is recommended to observe the interval between taking the drug at least 4 hours.
The maximum daily dose for adults is 4000 mg, for children aged 6 to 12 years - 2000 mg. If you need to use the drug for more than 3 days in a row, you should consult your doctor. It is not recommended to take the drug for more than 7 days in a row.
Patients suffering from impaired liver and / or kidney function need a dose adjustment of the drug.
Side effects
The drug is usually well tolerated by patients, however, in some cases, the following side effects may develop:From the gastrointestinal tract and liver: nausea, vomiting, pain in the epigastric region, increased activity of liver enzymes.
From the hematopoietic system: anemia, including hemolytic anemia, agranulocytosis, thrombocytopenia, pancytopenia. In addition, the development of methemoglobinemia is possible, the symptoms of which are cyanosis, shortness of breath and cardialgia.
Allergic reactions: skin rash, itching, urticaria, exudative erythema multiforme, toxic epidermal necrolysis and anaphylactoid reactions.
Others: a decrease in blood glucose levels up to hypoglycemic coma, bronchospasm (observed mainly in patients with increased individual sensitivity to nonsteroidal anti-inflammatory drugs), papillary necrosis and interstitial nephritis. Paracetamol can alter laboratory blood sugar and uric acid levels.
Contraindications
Increased individual sensitivity to the components of the drug.Hyperbilirubinemia, deficiency of glucose-6-phosphate dehydrogenase.
Severe violations of liver and / or kidney function.
Violations of the hematopoietic system, including anemia and leukopenia.
The drug Panadol and Panadol Solubl are not used to treat children under the age of 6 years.
Panadol Active is not used to treat children under the age of 12 years.
The drug should not be administered to patients suffering from alcoholism.
The drug should be used with caution in patients with liver and / or kidney disease.
Pregnancy
The drug does not have an embryotoxic, mutagenic and teratogenic effect, however, due to the fact that paracetamol penetrates the blood-placental barrier, its appointment during pregnancy is possible only if the expected benefit for the mother is higher than potential risks for the fetus.The drug can be prescribed during lactation by the attending physician, who must take into account possible risks for a child.
Drug interactions
When used in combination, the drug enhances therapeutic action coumarin anticoagulants, including warfarin.With the simultaneous use of metoclopramide and domperidone increase the absorption of paracetamol.
Cholestyramine, when combined, reduces the absorption of paracetamol.
With the simultaneous use of the drug with barbiturates, a decrease in the antipyretic effect of paracetamol is noted.
Microsomal oxidation inducers, isoniazid and hepatotoxic medicines increase the hepatotoxic effect of paracetamol.
The drug, when used simultaneously, reduces the effectiveness of diuretics.
The combined use of the drug with ethanol is contraindicated.
Overdose
When using the drug in doses significantly exceeding those recommended in patients, the development of toxic liver damage is possible. In addition, on the first day after an overdose of the drug, patients may develop nausea, vomiting, pallor of the skin, loss of appetite and abdominal pain. With a further increase in the dose, the development of metabolic acidosis and violations carbohydrate metabolism... In severe intoxication with the drug, the development of encephalopathy, bleeding, hypoglycemia and coma is possible.In case of an overdose, gastric lavage and the intake of enterosorbents are indicated. A specific antidote is N-acetylcysteine, which is used within the first 24 hours after taking excessive doses of the drug. If the patient does not develop vomiting, in case of an overdose, prescribe oral administration methionine. Treatment of an overdose of paracetamol should take place under strict medical supervision in a hospital setting.
- Official instructions for the drug Panadol.
Description of the drug " Panadol"on this page is a simplified and expanded version of official instructions by application. Before purchasing or using the drug, you should consult your doctor and familiarize yourself with the annotation approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide on the appointment of the drug, as well as determine the doses and methods of its use.
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