Instructions for the use of analgesic and antipyretic ibuprofen syrup for children. Ibuprofen - instructions for use for adults and children

Ibuprofen is an effective and safe antipyretic drug that has anti-inflammatory and analgesic properties, and is intended for use in children of all ages. For fever in children, Ibuprofen is the first antipyretic drug. The drug is available in the form of syrup, rectal suppositories, tablets and suspension. Such a wide selection of release forms has its own field of influence, which is important to know about for use at home. It is recommended to use the drug after a doctor’s permission, so you should first consult with your local doctor.

Main indications for use

The instructions for use of the drug Ibuprofen state that it should be used in case of complex therapy. The main indications for use include the following diseases:

infectious diseases accompanied by increased body temperature;
toothaches;
ARVI and various forms of influenza;
headache;
pain in the joints and muscles;
musculoskeletal injuries.

Instructions for use provide for a short course of treatment of the above diseases. If it is necessary to use the drug on a long-term basis, it is necessary to monitor the state of functioning of the liver, kidneys and peripheral blood. Ibuprofen for fever for children is used in various forms release, which depends not only on the patient’s age, but also on the form and type of disease. Let's take a closer look at each release form and find out in what cases the products are indicated for use.

Ibuprofen suppositories: in what cases should they be used?

Ibuprofen for children in the form of rectal suppositories is intended for use from the age of three months. The pediatrician prescribes Ibuprofen suppositories for the child if the following indications exist:

increased body temperature above 38-38.5 degrees;
pain in the throat area;
ARVI;
inflammation of the inner ear.

If the baby experiences symptoms of fever along with vomiting or nausea, then resorting to the use of forms of Ibuprofen other than suppositories is prohibited. This is due to the fact that during vomiting the entire composition of the drug will be removed from the body. The effectiveness of candles is not inferior to other forms of release of this product. It is not recommended to use rectal suppositories if a young patient has symptoms of diarrhea and diarrhea. The main contraindications for the use of ibuprofen suppositories include:

inflammatory processes in the intestines;
ulcerative types of diseases;
bronchial asthma;
bleeding in the gastrointestinal tract;
intolerance to the composition of the drug.

Ointment for the treatment of external inflammatory processes

The activity of Ibuprofen in the form of an ointment is due to its composition. The ointment is used if the following indications exist:

inflammatory processes in tendons;
bruise of non-skeletal tissues;
sharp pain in the lumbar region.

It is important to know! Ibuprofen in the form of ointment is approved for use in children over 12 years of age.

The ointment should be used externally only. To use, apply the ointment to the affected areas, then rub thoroughly until the cream is completely absorbed. skin. The interval between subsequent applications of the ointment should be at least 6 hours. The duration of treatment with ointment is no more than 20 days. Children are prohibited from using the product independently and only as prescribed by a doctor.

The main types of contraindications to the use of ointment are:

allergic manifestations;
presence of skin damage;
post-surgical period;
symptoms of dyspepsia.

Syrup, tablets and suspension

Syrup is the most popular form of Ibuprofen. Instructions for the use of Ibuprofen in the form of tablets, syrup and suspension state that doctors prescribe the drug for the following ailments:

toothaches;
disorders of the peripheral nerves;
arthritis, complicated by infectious symptoms;
migraine.

A special measuring syringe is included with the syrup. Using this syringe it is convenient to calculate the dosage of the drug.

Dosage and application features

When the temperature rises in children, it is recommended to give preference to this form of release, such as rectal suppositories. The disadvantage of this form of release, such as candles, is the long-lasting effect upon achieving positive results. Candles take longer to break down than tablets or syrup. Let's consider the features of using Ibuprofen in all available forms of release.

Pills

Ibuprofen tablets are recommended for children to take between meals. The medication is prescribed in dosages of 5 to 10 mg per 1 kg of body weight. Tablets are prescribed for use throughout the day 3-4 times a day. The basic dosage of taking tablets for children at different ages:

Age from 3 to 6 years – 300 mg/ daily dose.
Ages from 6 to 9 years – 400 mg.
Ages from 9 to 12 years – 600 mg.
Ages over 12 years – 800 mg.

Tablets are contraindicated for use in children under three years of age. The above dosage is approximate, and a more precise dosage should be checked with your doctor.

Suspension

Ibuprofen suspension has a quick effect compared to tablets. Before using the drug, shake the bottle thoroughly for 1 minute. Before use, be sure to read the instructions for use.

It is important to know! If you do not shake the syrup before use, the required amount of the active substances of the product will not enter the body.

The dosage for using syrup and suspension is almost identical. Both forms of release should be used for children aged 6 months and older. The dosage will be as follows:

at the age of 6 to 12 months, the dosage is 50 mg;
from 1 year to 3 years – 100 mg/3 times a day;
from 4 to 6 years – 150 mg / 3 times a day;
from 7 to 9 years – 200 mg/3 times a day;
from 10 to 12 years – 300 mg / 3 times a day.

Repeated administration of the medication is allowed no earlier than 6 hours later.

Candles

Rectal suppositories are intended directly for children aged 3 months and older. The instructions for use stipulate that after use the suppositories begin their effect on the body after 20-30 minutes. Suppositories must be stored exclusively in the refrigerator. Insert the candle into the child's anus carefully. First, you should unpack it, then hold it in your hand for about 1 minute, then insert it into anus, pushing it with your finger 3-4 cm.

Can a child under 3 months of age be given an Ibuprofen suppository? The instructions do not recommend administering the product to children under 3 months of age. If there is a need for this, you should consult a doctor who will prescribe a dosage or another drug. For children from 3 to 9 months of age, 1 suppository with a dosage of 60 mg should be used. The procedure can be repeated no earlier than after 6-8 hours.

It is important to know! Children under one year of age are allowed to use Ibuprofen no more than 3 times a day.

Children aged 9 months to 2 years should use one candle 4 times a day. The duration of use of Ibuprofen to reduce fever is 3 days, and as a pain reliever - no more than 5 days. It is strictly forbidden to increase the dose of the medication on your own.

What happens during an overdose

During an overdose, the following symptoms are observed:

vomiting and nausea;
abdominal pain;
migraine;
headache;
decreased appetite;
mental disorders;
renal and heart failure.

If there are signs of an overdose of an antipyretic drug, you should go to the hospital. If the symptoms of an overdose disappear after some time, the drug should not be used again. In case of overdose, children may experience worsened sleep and insomnia, so it is important to control the dosage of the drug. If the dosage of the drug was violated, you can give the child a drink carbon tablets. You should not wait for the development of adverse reactions, as they can appear after 2-3 hours.

Main types of contraindications

The instructions for use for any form of Ibuprofen describe the main types of contraindications. If they are present in a child, the use of the drug should be avoided and the doctor who prescribed the medicine should be informed. The main types of contraindications include diseases such as peptic ulcers, colitis, gastritis, and bleeding disorders. If there are impaired functioning of the kidneys, liver, heart and blood vessels, the drug should be used with caution.

If a young patient has diseases optic nerve, and increased sensitivity to the components of the medicine, you should completely exclude this drug in any form of release. Children under 6 years of age are allowed to use Ibuprofen only as directed by a doctor. During pregnancy and breastfeeding It is imperative to consult a doctor before taking the product in any form of release.

Drug interactions

If you use Ibuprofen in combination with other types of medications, you should definitely know the following:

When using Ibuprofen with other drugs from the NSAID group, a weakening of the effect of the antipyretic drug is observed.
When used together with anticoagulants and thrombolytics, the risk of internal bleeding increases.
Combined use with gold preparations increases medicinal properties, as well as a decrease in the rate of elimination of the drug from the body.

It is important to exercise caution and monitor your dosage when taking Ibuprofen. The drug is sold in pharmacies without a prescription, so it is important to follow the dosage prescribed by the doctor. Continue therapeutic treatment more than 5 days without a doctor's prescription is strictly prohibited. At the slightest sign of deterioration in the patient’s well-being, it is necessary to exclude the use of the medicine.

In conclusion, it should be noted that Ibuprofen is universal remedy, allowing to normalize the condition of young patients, reduce pain, lower high body temperature, and cure viral and infectious diseases. The drug is effective only if it is used correctly.

Tradename

Ibuprofen

Dosage form

Suspension for oral administration (for children).

Ibuprofen Composition

5 ml of suspension contains:

active substance- ibuprofen 100 mg;
Excipients- polysorbate 80 - 3.0 mg, glycerol - 500.0 mg, sorbitol - 1050.0 mg, sodium saccharinate - 1.5 mg, citric acid - 7.5 mg, xanthan gum - 30.0 mg,
0.5 M sodium hydroxide solution - 1.071 g, 0.5 M hydrochloric acid solution - 0.982 g, methyl parahydroxybenzoate - 5.0 mg, propyl parahydroxybenzoate - 1.5 mg, orange flavoring - 1.0 mg, purified water up to 5 ml.

Ibuprofen Description

Homogeneous white or almost white viscous suspension with the smell of orange.

Pharmacotherapeutic group

Nonsteroidal anti-inflammatory drug (NSAID), a derivative of phenylpropionic acid.

ATX CODE

Pharmacological properties

It has an analgesic, antipyretic and anti-inflammatory effect due to the indiscriminate blockade of cyclooxygenase (COX1 and COX2) and has an inhibitory effect on the synthesis of prostaglandins; the analgesic effect is most pronounced in cases of inflammatory pain; Like all NSAIDs, ibuprofen exhibits antiplatelet activity. The effect of the drug is due to inhibition of prostaglandin synthesis by blocking the enzyme cyclooxygenase. Suppresses platelet aggregation. With long-term use it has a desensitizing effect.

Pharmacokinetics

Well absorbed from the gastrointestinal tract. Absorption is slightly reduced when taking the drug after meals. TC max when taken on an empty stomach - 45 minutes, when taken after meals - 1.5 - 2.5 hours, in synovial fluid - 2-3 hours (where it creates higher concentrations than in plasma). 90% bound to plasma proteins. Subject to presystemic and postsystemic metabolism in the liver. After absorption, approximately 60% of the pharmacologically inactive R form of ibuprofen is slowly transformed into the active S form. The CYP2C9 isoenzyme takes part in the metabolism of the drug. It has two-phase elimination kinetics with T 1/2 2-2.5 hours (for retard forms - up to 12 hours). It is excreted by the kidneys (no more than 1% unchanged) and, to a lesser extent, with bile.

Ibuprofen Indications for use

Ibuprofen is used for children from 6 months to 12 years as an antipyretic for acute respiratory diseases, flu, childhood infections, post-vaccination reactions and other infectious and inflammatory diseases accompanied by an increase in body temperature. The drug is used as an analgesic for pain of mild or moderate intensity, including headaches and toothaches, migraines, neuralgia, pain in the ears and throat, pain with sprains and other types of pain.

Contraindications

Hypersensitivity, erosive and ulcerative diseases of organs gastrointestinal tract(Gastrointestinal tract) in the acute stage (including peptic ulcer stomach and duodenum, ulcerative colitis, Crohn's disease), complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including a history), bleeding disorders (including hemophilia, prolongation of bleeding time, tendency to bleed, hemorrhagic diathesis), active gastrointestinal bleeding; heavy renal failure(creatinine clearance less than 30 ml/min), progressive kidney disease, severe liver failure or active liver disease, condition after coronary artery bypass surgery, confirmed hyperkalemia, inflammatory diseases intestines, hereditary fructose intolerance due to the presence of medicinal product includes sorbitol. Take with CAUTION for - liver cirrhosis with portal hypertension; liver and/or renal failure, heart failure, nephrotic syndrome, hyperbilirubinemia, gastric ulcer and duodenum(history), gastritis, enteritis, colitis, blood diseases unknown etiology(leukopenia and anemia), pregnancy (II-III trimester), during lactation. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study; During the treatment period, ethanol intake is not recommended; to reduce the risk of developing adverse events from the gastrointestinal tract
The minimum effective dose should be used for the shortest possible short course. In patients bronchial asthma or other diseases associated with bronchospasm, Ibuprofen may increase the risk of bronchospasm. The use of the drug in these patients is permissible only if great caution is observed, and in case of difficulty breathing, you should immediately consult a doctor.

Ibuprofen Method of administration and dosage

Ibuprofen is taken orally after meals. Shake before use to obtain a homogeneous suspension.
Children from 6 to 12 months (7-9 kg) 3 to 4 times 2.5 ml during the day;
Children from 1 year to 3 years (10-15 kg) 3 times 5 ml during the day;
Children from 3 to 6 years old (16-20 kg) 3 times 7.5 ml during the day;
Children from 6 to 9 years old (21-29 kg) 3 times 10 ml during the day;
Children from 9 to 12 years old (30-40 kg) 3 times 15 ml during the day;
For post-vaccination reactions in infants from 3 to 6 months:
Infants from 3 to 6 months (5-7.6 kg): 2 times 2.5 ml during the day (take 2.5 ml, if necessary, repeat 2.5 ml after 6 hours).
The duration of treatment for fever is no more than 3 days, for pain syndrome - no more than 5 days.

Side effect

from the outside digestive system: NSAIDs - gastropathy (nausea, vomiting, abdominal pain, heartburn, loss of appetite, diarrhea, flatulence, pain and discomfort in the epigastric region), ulcerations of the gastrointestinal mucosa (in some cases complicated by perforation and bleeding); irritation, dryness of the oral mucosa or pain in the mouth, ulceration of the gum mucosa, aphthous stomatitis, pancreatitis, constipation, hepatitis;
from the outside respiratory system: shortness of breath, bronchospasm; from the sensory organs: hearing loss, ringing or noise in the ears, reversible toxic optic neuritis,
vagueness visual perception or diplopia, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic origin), scotoma;
from the nervous system: headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations, rarely - aseptic meningitis (more often in patients with autoimmune diseases);
from the outside of cardio-vascular system: development or worsening of heart failure, tachycardia, increased blood pressure;
from the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome(edema), polyuria, cystitis; allergic reactions: skin rash(usually erythematous, urticaria), itchy skin, angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm, fever, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), eosinophilia, allergic rhinitis;
from the hematopoietic organs: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia; other: increased sweating; the risk of developing ulcerations of the gastrointestinal mucosa, bleeding (gastrointestinal, gingival, uterine, hemorrhoidal), visual impairment (impaired color vision, scotoma, amblyopia) increases with long-term use in large doses.

Overdose

Symptoms of ibuprofen overdose in children: abdominal pain, nausea, vomiting, lethargy, headache, tinnitus, depression, drowsiness, metabolic acidosis, coma, hemorrhagic diathesis, decreased blood pressure, convulsions, apnea, acute renal failure, liver dysfunction, tachycardia, bradycardia, atrial fibrillation, forced diuresis. Children under 5 years of age are especially prone to apnea, coma, and seizures.
Serious consequences associated with the toxic effect of the drug usually appear after taking a dose exceeding 400 mg/kg body weight (i.e. 80 recommended single doses). If an overdose is suspected, consult a doctor immediately.
Treatment for overdose: gastric lavage, taking activated carbon, alkaline drink, symptomatic therapy (correction of CBS, blood pressure).

special instructions

During long-term use, non-steroidal anti-inflammatory drugs can cause damage to the gastric mucosa, peptic ulcers and bleeding from the stomach. digestive tract. During long-term treatment with NSAIDs, monitoring of peripheral blood patterns and functional state liver and kidneys. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a blood test to determine Hb, hematocrit, and a stool test for occult blood.
Interaction with other drugs Ibuprofen should not be used simultaneously with other non-steroidal anti-inflammatory drugs (for example, acetylsalicylic acid reduces the anti-inflammatory effect of ibuprofen and increases side effects). If possible, the simultaneous administration of ibuprofen and diuretics should be avoided, due, on the one hand, to a weakening of the diuretic effect and, on the other, to the risk of developing renal failure. Ibuprofen weakens the effect antihypertensive drugs(angiotensin convertase inhibitors, -adrenergic agents, thiazides). Inhibits the hypotensive effect ACE inhibitors, while simultaneously reducing their excretion by the kidneys. Ibuprofen enhances the effect of oral hypoglycemic agents (especially sulfonylureas) and insulin. Inducers of microsomal oxidation phenytoin, ethanol, barbiturates, zixorin, rifampicin, phenylbutazone, tricyclics (antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions. Inhibitors of microsomal oxidation - reduce the risk of hepatotoxicity. Strengthens the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics (increasing the risk of hemorrhagic complications). Increases the concentration of digoxin in the blood. Strengthens toxic effect methotrexate and lithium preparations. Caffeine enhances the analgesic effect.

Release form

Oral suspension (for children) 100 mg/5 ml. 90 ml, 100 ml, 110 ml, 115 ml or 125 ml in orange glass bottles or jars with a screw neck, sealed with polyethylene stoppers and screw caps made of polymer materials or aluminum caps with perforation.
90 ml, 100 ml, 110 ml, 115 ml or 125 ml in brown glass bottles, sealed with caps made of polymer materials.
Each bottle or jar, along with instructions for use and a measuring cup or measuring spoon or dosing syringe, is placed in a cardboard pack.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children!
Shelf life: 2 years. Do not use after expiration date!

In this article you can read the instructions for use of the drug Ibuprofen. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Ibuprofen in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Ibuprofen analogues in the presence of existing structural analogues. Use for the treatment of inflammation and fever, as well as pain relief in adults, children, as well as during pregnancy and lactation.

Ibuprofen- non-steroidal anti-inflammatory drug, a derivative of phenylpropionic acid. It has anti-inflammatory, analgesic and antipyretic effects.

The mechanism of action is associated with inhibition of the activity of COX, the main enzyme in the metabolism of arachidonic acid, which is a precursor of prostaglandins that play main role in the pathogenesis of inflammation, pain and fever. The analgesic effect is due to both peripheral (indirectly, through suppression of prostaglandin synthesis) and central mechanism(due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). Suppresses platelet aggregation.

When applied externally, it has an anti-inflammatory and analgesic effect. Reduces morning stiffness and helps increase range of motion in joints.

Pharmacokinetics

When taken orally, ibuprofen is almost completely absorbed from the gastrointestinal tract. Simultaneous use food slows down the rate of absorption. Metabolized in the liver (90%). 80% of the dose is excreted in the urine mainly in the form of metabolites (70%), 10% - unchanged; 20% is excreted through the intestines in the form of metabolites.

Indications

inflammatory diseases of the joints and spine (incl. rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, gouty arthritis);
moderate pain syndrome of various etiologies(including headache, migraine, toothache, neuralgia, myalgia, postoperative pain, post-traumatic pain, primary algodismenorrhea);
febrile syndrome with “colds” and infectious diseases;
created for symptomatic therapy, reducing pain and inflammation at the time of use, does not affect the progression of the disease.

Release forms

Film-coated tablets 200 mg and 400 mg.

Candles for rectal use for children 60 mg.

Gel for external use 5%.

Ointment for external use 5%.

Syrup or suspension for oral administration.

Effervescent tablets Ibuprofen - Hemofarm.

Instructions for use and dosage

Ibuprofen is prescribed to adults and children over 12 years of age orally, in tablets of 200 mg 3-4 times a day. To achieve fast therapeutic effect the dose can be increased to 400 mg (2 tablets) 3 times a day. Upon reaching therapeutic effect the daily dose of the drug is reduced to 600-800 mg. The morning dose is taken before meals with sufficient quantity water (for faster absorption of the drug). The remaining doses are taken throughout the day after meals.

The maximum daily dose is 1200 mg (do not take more than 6 tablets in 24 hours). Take a repeat dose no more often than after 4 hours. The duration of use of the drug without consulting a doctor is no more than 5 days.

Do not use in children under 12 years of age without consulting a doctor.

Children from 6 to 12 years old: 1 tablet no more than 4 times a day; the drug can only be used if the child’s body weight is more than 20 kg. The interval between taking tablets is at least 6 hours (daily dose no more than 30 mg/kg).

Apply externally for 2-3 weeks.

The maximum daily dose for adults when taken orally or rectally is 2.4 g.

Side effect

NSAID gastropathy (abdominal pain, nausea, vomiting, heartburn, loss of appetite, diarrhea, flatulence, constipation; rarely - ulceration of the gastrointestinal mucosa, which in some cases is complicated by perforation and bleeding);
irritation or dryness of the oral mucosa;
mouth pain;
ulceration of the gum mucosa;
dyspnea;
bronchospasm;
hearing impairment: hearing loss, ringing or tinnitus;
visual disturbances: toxic damage to the optic nerve, blurred vision or double vision
dryness and irritation of the eyes;
swelling of the conjunctiva and eyelids (allergic origin);
headache;
dizziness;
insomnia;
anxiety;
nervousness and irritability;
psychomotor agitation;
drowsiness;
depression;
confusion;
hallucinations;
heart failure;
tachycardia;
increased blood pressure;
allergic nephritis;
skin rash (usually erythematous or urticaria);
skin itching;
Quincke's edema;
anaphylactoid reactions;
anaphylactic shock;
fever;
allergic rhinitis;
anemia (including hemolytic, aplastic);
thrombocytopenia and thrombocytopenic purpura;
agranulocytosis;
leukopenia;
increased sweating.

Laboratory indicators:

bleeding time (may increase);
serum glucose concentration (may decrease);
creatinine clearance (may decrease);
hematocrit or hemoglobin (may decrease);
serum creatinine concentration (may increase);
activity of “liver” transaminases (may increase).

Contraindications

hypersensitivity to any of the ingredients included in the drug. Hypersensitivity to acetylsalicylic acid or other NSAIDs, incl. anamnestic data on an attack of bronchial obstruction, rhinitis, urticaria after taking acetylsalicylic acid or other NSAIDs; complete or incomplete acetylsalicylic acid intolerance syndrome (rhinosinusitis, urticaria, nasal polyps, bronchial asthma);
erosive and ulcerative diseases of the gastrointestinal tract in the acute stage (including peptic ulcer of the stomach and duodenum, Crohn's disease, ulcerative colitis);
inflammatory bowel diseases;
hemophilia and other bleeding disorders (including hypocoagulation), hemorrhagic diathesis;
period after coronary artery bypass surgery;
gastrointestinal bleeding and intracranial hemorrhage;
severe liver failure or active liver disease;
progressive kidney disease;
severe renal failure with creatinine clearance less than 30 ml/min, confirmed hyperkalemia;
pregnancy;
children under 6 years of age.

Use during pregnancy and breastfeeding

Contraindicated during pregnancy. Use with caution during lactation.

special instructions

Treatment with the drug should be carried out with minimal effective dose, the shortest possible course. During long-term treatment, monitoring of the peripheral blood picture and the functional state of the liver and kidneys is necessary. If symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, general analysis blood (hemoglobin determination), stool test for occult blood.

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.

Patients should refrain from all activities requiring increased attention, fast mental and motor reactions. During the treatment period, ethanol (alcohol) intake is not recommended.

Drug interactions

Concomitant use of ibuprofen with acetylsalicylic acid and other NSAIDs is not recommended. When administered simultaneously, ibuprofen reduces the anti-inflammatory and antiplatelet effect of acetylsalicylic acid (possibly increasing the incidence of acute coronary insufficiency in patients receiving small doses of acetylsalicylic acid as an antiplatelet agent after starting ibuprofen). When prescribed with anticoagulant and thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding simultaneously increases. Concomitant use with serotonin reuptake inhibitors (citalopram, fluoxetine, paroxetine, sertraline) increases the risk of developing serious gastrointestinal bleeding.

Cefamandole, cefaperazone, cefotetan, valproic acid, plicamycin, increase the incidence of hypoprothrombinemia. Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostaglandins in the kidneys, which is manifested by increased nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects. Drugs that block tubular secretion reduce excretion and increase plasma concentrations of ibuprofen. Inducers of microsomal oxidation (phenytoin, ethanol (alcohol), barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of developing severe intoxications. Inhibitors of microsomal oxidation - reduce the risk of hepatotoxicity. Reduces the hypotensive activity of vasodilators, natriuretic and diuretic activity of furosemide and hydrochlorothiazide. Reduces the effectiveness of uricosuric drugs, enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics (increasing the risk of hemorrhagic disorders), enhances the ulcerogenic effect with bleeding of mineralocorticosteroids, glucocorticosteroids, colchicine, estrogens, ethanol (alcohol). Enhances the effect of oral hypoglycemic drugs medicines and insulin, sulfonylurea derivatives. Antacids and cholestyramine reduce absorption. Increases the blood concentration of digoxin, lithium preparations, methotrexate. Caffeine enhances the analgesic effect.

Analogues of the drug Ibuprofen

Structural analogues of the active substance:

Advil;
ArthroCam;
Bonifen;
Brufen;
Brufen retard;
Burana;
Deblock;
Children's Motrin;
Dolgit;
Ibuprom;
Ibuprom Max;
Ibuprom Sprint Caps;
Ibuprofen Lannacher;
Ibuprofen Nycomed;
Ibuprofen-Verte;
Ibuprofen-Hemofarm;
Ibusan;
Ibutop gel;
Ibufen;
Yprene;
MIG 200;
MIG 400;
Nurofen;
Nurofen for children;
Nurofen Period;
Nurofen UltraCap;
Nurofen forte;
Nurofen Express;
Pedea;
Solpaflex;
Faspik.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

Antipyretic syrup Ibuprofen for children is recognized as one of the most effective. It allows you to quickly relieve fever and reduce the temperature by at least 1 degree. At the same time, reviews note that Ibuprofen works even in the most severe cases, when paracetamol was powerless. How to use the drug correctly?

Compound

According to the instructions, the medicine contains the main substance of the same name, ibuprofen. Various excipients are used as syrup fillers for children.

Ibuprofen is sold in the form of a white powder, from which a suspension is prepared using boiled water. It turns out white with the smell of orange. The price for it is not too high.

Ibuprofen syrup for children, according to the instructions for use, can be used to reduce fever, eliminate pain, and relieve inflammation. Ibuprofen is well absorbed from the gastrointestinal tract and excreted by the kidneys.

Indications and contraindications

The instructions for use list the following indications for which Ibuprofen syrup is prescribed for children:

acute viral and bacterial infections accompanied by an increase in temperature;
reactions to vaccinations;
pain (migraines, ear and toothache, pain from sprains and bruises).

But still, ibuprofen is most often used for children as an effective antipyretic.

Ibuprofen syrup for children has quite broad contraindications, according to the instructions for use:

age of children up to six months;
gastrointestinal diseases;
impaired blood clotting;
bronchial asthma;
polyps in the sinuses;
individual intolerance;
severe liver and kidney diseases;
hyperkalemia;
after coronary bypass surgery.

For some of these conditions, Ibuprofen syrup can be used, but only under the strict supervision of a doctor.

Ibuprofen for children tends to increase bronchospasm, so it is highly not recommended for asthma. Instructions for use also include wide list its compatibility with other drugs and warnings for use with other medications. So parents’ independent use of medication, especially for the first time, should be very careful, and the dosage should be strictly observed.

How to use?

First you need to prepare the syrup itself. According to the instructions, to do this, pour warm boiled water into the bottle halfway and shake well. After the medicine has dissolved, the instructions for use recommend adding more water to the mark indicated on the bottle. Shake the syrup before use.

Then use a measuring syringe to draw out the required amount of syrup. The dosage, as indicated in the instructions for use, should be as follows (Ibuprofen syrup should be given 3-4 times a day no earlier than 6 hours after the last dose):

from six months to a year (up to 9 kg) - two and a half ml;
from 1 to 3 years - five ml;
from 3 to 6 years - seven and a half ml;
from 6 to 9 years - ten ml;
from 9 to 12 years - fifteen ml.

Ibuprofen is also used for children from 3 to 6 months with post-vaccination reactions. For fever, the drug is used only for 3 days. For pain, the period of use is 5 days.

Side effects

Ibuprofen for children has quite a lot side effects. Compared to paracetamol, it seems less safe, but reviews claim that side effects are quite rare.

Side effects include:

diseases of the digestive system;
shortness of breath;
spasms in the bronchi;
disturbance of visual and auditory perception;
anxiety, depression, nervous system disorders;
heart failure, hypertension;
kidney disease, nephritis;
gastric and hemorrhoidal bleeding, anemia.

In case of overdose, the following symptoms may occur:

nausea, vomiting;
depression, drowsiness, lethargy;
dysfunction of the liver and kidneys;
Children under 5 years of age may experience apnea, convulsions, and coma.

For a serious overdose to occur, it is necessary to exceed the permissible single dose by 80 times.

If the dosage has been exceeded, you should empty your stomach and induce vomiting. If the child is very ill, call an ambulance and do not give any other medications until the doctors arrive.

Analogs, price

Ibuprofen syrup for children has many analogues. There are medications based on the active ingredient ibuprofen. The most popular are the following:

Nurofen is an analogue that can be given to children from 5 years of age;
MIG is an anesthetic drug recommended for children over 12 years of age and adults;
Ibuprofen in the form of suppositories and gel.

Among less known analogues can be distinguished:

Advil;
Burana;
Dolgit;
Faspik.

Many parents are concerned about the question of whether it is worth resorting to Ibuprofen analogues if they are more expensive, and no one can vouch for the quality. Perhaps there really is no point in purchasing analogues. The most the best analogue still remains Nurofen. This is the most popular ibuprofen-based medicine.

The price of Ibuprofen or Nurofen is relatively small - from 70 to 90 rubles, depending on the region and pharmacy. So there's no point in spending money on expensive analogues, if you can buy Ibuprofen syrup for your child.

How effective?

The price of Ibuprofen suits many buyers. It is small, but the benefits brought exceed the funds spent. What do parents like about this drug?

Fast action. Although the instructions for use recommend Ibuprofen and its analogues for pain relief and against fever, parents tend to use it more as an antipyretic.
Helps with almost any infection. Amazing property Ibuprofen is able to help with almost any type of infection. When paracetamol is powerless, parents resort to ibuprofen. It quickly relieves pain and fever.
Almost not side effects. Although the manufacturer of the drug claims in the instructions for use that the medicine has quite a lot of side effects, in reality there are quite a few of them. Children rarely complain of pain or other discomfort after taking ibuprofen or medications containing this substance. This explains its increased popularity combined with high efficiency.
Convenient form of administration. As you know, children are very reluctant to take certain medications. Often the cause of refusal or whims is the unpleasant, bitter taste of drugs. Nurofen has a pleasant fruity taste, which makes it extremely beneficial. Kids calmly drink it this way.

What to do if the medicine is not suitable or does not work?

Check the expiration date: Give children only fresh medications.

If everything was fine with the drug, but it still didn’t help, you are dealing with a very serious illness. In this case, you need to call an ambulance for the child, who will give an injection with diphenhydramine and relieve the temperature. If the temperature does not go down, the child is sent to the hospital, and Ibuprofen sometimes becomes unnecessary.

However, this effective remedy from pain and heat, and it continues to remain so.

Often inflammatory process in the child's body is accompanied elevated temperature And painful sensations. This may be due to the flu, acute respiratory infections, childhood infections, or a reaction to a vaccine. Antipyretic drugs will help alleviate the baby’s condition and relieve the symptoms of the disease. Children's Ibuprofen is one of them.

A review of the medication will help mothers decide whether to use it.

Ibuprofen has analgesic, anti-inflammatory properties, and has a moderate antipyretic effect.

Indications for use

Ibuprofen is effective:

as a means to lower fever with fever due to acute respiratory infections, influenza, infectious diseases or reactions to vaccination;
as a pain reliever during headaches, dental and muscle pain, ear and throat pain, as well as during various injuries.

Review by Evgenia N.:

"From colds no one is immune. I have two preschool children. Of course they get sick. I have always used it as an antipyretic. Somehow it wasn’t in the pharmacy, so I was offered to buy an analogue - Ibuprofen. The main active substance is the same, but the price is much lower. For my children, Ibuprofen was no worse and even more effective. 30 minutes after application the temperature subsides. Now we use it."

Composition and action

Ibuprofen is a non-hormonal anti-inflammatory drug.

The active component in its composition is called ibuprofen. The mechanism of action of the substance is aimed at suppressing the synthesis of biologically active prostaglandins (substances that promote the inflammatory process).

The drug has wide range actions:

anti-inflammatory;
antipyretic;
painkiller.

Therefore, it is actively used in the complex treatment of childhood diseases.

The effect of use comes quickly (body temperature begins to drop after 15-20 minutes) and lasts long time(within 6 - 8 hours).

Review by Maria K.:

“My one and a half year old baby was given DPT. The doctor warned about possible reactions for vaccination. I decided to take care of the antipyretic in advance. At the pharmacy, the pharmacist recommended Ibuprofen. I bought it. In the evening Dashulya got up heat. I had to resort to medicine - I gave 2.5 ml of syrup. Half an hour later, my girl’s temperature subsided and she fell asleep. Contrary to my fears, the effect of the drug lasted for a long time - my daughter slept peacefully until the morning.”

Important! Ibuprofen is not an antiviral or antibacterial agent.

Release forms

Ibuprofen is available in the following forms:

suspension;
rectal suppositories;
gel;
ointment;
pills.

Suspension- liquid orange color with a sweetish orange flavor. It is designed to treat children from three months of age.

Used to lower fever, reduce pain and inflammation.

If your baby develops a fever after vaccination, you should give your child medicine.

In case of reactions to vaccinations in children under 3 months of age (including newborns), the use of the suspension is possible after consultation with a doctor.

It is this form that is most often used to treat children, so later in the article we will mainly write about it. Some mothers call it syrup (because of the sweet taste), and ask pharmacies not for the suspension, but for Ibuprofen syrup, but this is not entirely true * (although pharmacists understand this too).

*Suspension is a suspension of small solid particles in a liquid substance.

All substances are completely dissolved in the syrup.

For acute respiratory viral infections, otitis media, throat diseases and reactions to vaccination, pediatricians recommend the use of suppositories for children from 3 months to 2 years old. Candles - convenient form for the treatment of infants. It is not always possible to spoon-feed such patients with medicine.

If a child is vomiting and has a high temperature, it is better to use antipyretic suppositories.

Gel and ointment- anti-inflammatory drugs for external use for muscle pain, inflammation of joints and soft tissues, injuries. The use of the drug for the treatment of children under 12 years of age is possible as prescribed by a doctor.

Manufacturers

Ibuprofen suspension is produced by the Russian manufacturer EKOlab CJSC in a 100 ml brown glass bottle. The medicine is packaged in a cardboard box, equipped with a measuring spoon and an insert containing instructions for use.

In pharmacies you can find “Ibuprofen” and “Ibuprofen-FT” from the Belarusian manufacturer “Pharmtekhnologiya” LLC, 50 ml, 100 ml and 150 ml in a plastic bottle with a measuring spoon or dosing syringe.

The Russian company Akrikhin OJSC produces a suspension for children “Ibuprofen Akrikhin” in 100 ml dark glass bottles complete with a dispensing spoon and in 100 ml plastic bottles complete with a dispensing syringe.

The average price of the drug is 75 rubles.

How to take the suspension

Read the instructions for use of children's Ibuprofen (). Clearly calculate the dosage taking into account the age and weight of the child.

Before use, pay attention to the expiration date. It is indicated on the box. Take out the bottle of medicine and shake the contents well.

Some babies are more willing to take medicine from a spoon rather than from a syringe.

In the kit you will find a measuring spoon or dispenser syringe. Measure the required amount of medicine according to the weight and age of the baby and give it to the child.

Wash and dry the measuring spoon or syringe thoroughly after use.

Important! An increase in body temperature is an indicator of struggle child's body with infection. The temperature is usually not brought down below 38.5 degrees.

Dosages by age

The dosage of Ibuprofen is calculated taking into account the child’s age and weight. Per 1 kg body weight single dose is 10 mg. Repeated administration of the medicine is possible after 8 hours; if urgently necessary, the interval can be reduced to 4 hours. The suspension is taken after meals, it can be washed down with a small amount of water.

To calculate the amount of a substance, you can use the table.

If it is needed long-term treatment, then you will need to consult a specialist.

The drug can be used as an antipyretic no more than three days. If the suspension is necessary to relieve pain, the drug can be extended to 5 days.

Important! Simultaneous use of several drugs with the same active substance strictly prohibited. Overdose is possible.

Review by Marina L.:

“I have been familiar with Ibuprofen in suspension form for 4 years. In all this time, the medicine has never let me down. I always reduce the calculated dose slightly. The drug works great. Within 20 minutes my daughter was cheerful and cheerful again. I did not observe any side effects or allergic reactions. We just didn't have them."

Side effects and contraindications

Children's Ibuprofen is usually well tolerated by young patients. However, when used, there is a possibility of side effects:

stomach pain, discomfort, nausea and vomiting;
suffocation, exacerbation of asthma, bronchospasm;
headaches, dizziness, irritability, drowsiness;
allergic reaction, skin rash, urticaria, itching, possible angioedema.

If a child has adverse reaction- call the doctor.

The appearance of any of the above symptoms is fraught with complications. In such cases, you should stop taking the drug and seek medical help.

Contraindications to the use of the suspension:

individual intolerance to the components of the product;
severe insufficiency of liver and kidney function;
manifestation allergic reaction on any non-steroidal anti-inflammatory drug;
stomach diseases in the acute phase;
blood clotting disorder;
children up to three months old.

Analogues of the drug

On the drug market there are analogues of Ibuprofen with the same name. active substance. Their mechanism of action is the same. The drugs differ only in price. For comparison:

Nurofen - 195 rubles;
Befron - 120 rubles;
Ibufen D - 195 rubles.

An analogue of Ibuprofen - Nurofen - the medicine is used as an antipyretic for acute respiratory diseases, influenza, and childhood infections.

Ibuprofen is effective and inexpensive remedy for the treatment of children. However, there are contraindications to its use. Before taking the drug, be sure to read the instructions and consult your doctor. Remember - the baby's health is in your hands!

Elena Vasilyeva