Hypertension is spreading at an incredible rate throughout the world. According to statistics in Russia, 30% of the population suffers from arterial hypertension, and this figure is increasing year by year. These are those who have already been officially diagnosed.
And how many people who did not apply for medical care? Nobody knows. Even among children, cases of hypertension are recorded. Every year, military registration and enlistment offices weed out more than 40% of young people with high blood pressure! The statistics are disappointing! And what will happen next?
How does Indap work?
Indap tablets are prescribed for high blood pressure, which is considered such at rates from 140 to 90.
The drug, blocking calcium channels, quickly lowers the pressure by the fact that, by expanding the vessels, it also has a diuretic effect, due to which the exerting agents begin to be excreted from our body. harmful effect on the work of the heart and blood vessels components such as sodium and chlorine.
Also, the drug helps to reduce the synthesis of oxygen radicals, which harms healthy vascular cells.
The desired effect begins to be observed after a week of using the drug. The effect of one tablet or capsule lasts for 24 hours.
Indap breaks down in the liver and is excreted from the body with feces and urine. Renal failure does not affect the excretion of the drug. The advantage of the drug is that it does not have a cumulative effect and you can stop taking it not gradually, but immediately.
The product can be used by patients with mild diabetes mellitus and moderate but strictly under medical supervision. It has no effect on carbohydrate metabolism and its use does not change the level of lipids in the blood. 
If you systematically use this medicine, then the walls of the vessels become elastic, and their peripheral resistance.
How long can I take Indap? Its greatest efficiency is observed when monthly intake medicines. The effect of the reception will last for two months. Often, if necessary, the use of the drug is prescribed for life, regardless of pressure indicators.
If the doctor prescribed to drink Indap daily, then you should not cancel his decision on your own, but it is better to seek advice.
What is included in the composition of the drug and in what forms it is produced
The active ingredient of the drug Indap is indapamide - 2.5 mg. Its composition is also supplemented with excipients:
The drug is produced not in tablets, but in capsules, which are absorbed by the body much better than tablets. The composition of the shell itself includes gelatin, titanium dioxide and indigo dye. Capsules are bicolor (half of the shell is blue, half is white). The capsules contain a white or yellowish powder.
Why is Indap prescribed
According to the instructions for use, the drug is prescribed at high pressure, that is, if the patient is diagnosed with "arterial hypertension". Also, the indications for use include the presence of edema that occurs with heart failure.
The medicine works well complex therapy in conjunction with the use of drugs such as beta-blockers and cardiac glycosides.
Can the drug be used by pregnant and lactating women
Indap is categorically contraindicated for women in position, as well as for breastfeeding. It is extremely dangerous for the unborn child in that when it is used, there is a threat of fetoplacental ischemia, in which there is a delay in the development of the fetus and its hypoxia.
Since the agent is able to penetrate the barriers between tissues and blood, it can easily end up in the milk of a nursing woman. If the doctor nevertheless prescribed a nursing mother to take this remedy if it is urgent, then she should stop breastfeeding.
In what cases is the medication contraindicated?
Most of chemicals to lower blood pressure has numerous contraindications. Indap is no exception. Experts do not recommend using it in the presence of:
- Acute disruption of the brain;
- Age up to 18 years;
- pregnancy;
- Acute failure of the functioning of the liver and kidneys;
- Gout;
- With a lack of potassium in the body (hypokalemia);
- decompensated diabetes;
- High sensitivity to constituents medicinal product.
Carefully it is necessary to carry out treatment with the drug for elderly people, patients with diabetes mellitus, in the presence of arrhythmia, moderate failure of the kidneys and liver, ischemia and heart failure.
All prescriptions for therapy with Indap are made by a doctor. Self-medication is fraught with disastrous consequences.
Like any antihypertensive, Indap is absolutely incompatible with the use of alcohol. The threat is a sharp drop in blood pressure, which can lead to dire consequences, including death. Therefore, before taking alcohol, it is worth stopping taking the drug 24 hours in advance for men, and 32 hours for women.
After alcoholic libations, you can start using the medicine no earlier than after 14 hours for men and after 20 hours for women.
What are the possible side effects during treatment with Indap?
The drug is generally well tolerated by patients. Indap is the best diuretic with the least amount of side effects, but they still exist and manifest themselves:
What happens in case of an overdose of the drug
If an overdose of the drug occurs, this manifests itself:
In case of drug poisoning, medical attention should be called as soon as possible.
How the medicine is taken
How to take Indap? Usually, a 2.5 mg capsule is taken once a day before meals with a sip of water. Her action is enough for the whole day. They drink the medicine for 1-2 months, then you can take a two-week break. The exception is those cases when the drug is prescribed for life.
When taking the capsule at the same time as eating, its absorption slows down, but the amount of the substance that enters the bloodstream does not change.
Interaction of Indap with other drugs
Indap can not be combined with all drugs. If it is consumed with substances containing calcium, then there will be an excess of calcium in the blood. Indapamide is also incompatible with lithium preparations. Lithium toxicity may be caused.
Simultaneous reception with iodine-containing substances threatens to impair kidney function.
The drug is incompatible with antibiotics, hormonal means, with some cardiac glycosides, psychotropic substances. It should not be used with other diuretics.
With which drugs you can take the remedy, and with which you can’t, when prescribing Indap, the attending physician should consult. Self-medication often leads to negative consequences- Don't tempt fate.
How much is Indap
The price of Indap varies from 65 to 120 rubles per pack, depending on the manufacturer, region and pharmacy chain.
What are the analogues of the drug
There are several analogues of Indap, these are:
More cheap analogue Indapamide is no worse than Indap. Preparations of the same effect and have the same composition, however, you still should not replace one medicine with another on your own, but it is better to consult with your doctor.
Reviews
Like every drug, Indap has mixed reviews from both doctors and patients. We are all different, and everyone's organisms are individual, so there can not be only good reviews about the same drug. He helps someone well, but someone is dissatisfied with his action. And this is considered normal.
Basically, the drug is good feedback. It is almost always well tolerated by patients, has the desired effect. Doctors quite often prescribe it to patients as additional funds to normalize blood pressure in combination with other drugs.
The doctors themselves speak well of this remedy, and numerous positive reviews patients say a lot:
Indap is popular among hypertensive patients. He has performed quite well. Although its side effects are numerous, they do not often manifest themselves. The drug acts gently and gradually, slowly but surely returning arterial pressure to normal levels. The most important thing is that the medicine works and its price is acceptable. All this is about Indap.
Medications that lower blood pressure are called antihypertensives (hypotensives). A decrease in blood pressure is achieved different ways depending on the etiology, mechanism of development and clinical picture arterial hypertension.
What is the antihypertensive effect?
The antihypertensive effect is the effect that a group of drugs has, whose action is aimed at eliminating the factors that provoke high blood pressure numbers:
- increased tone of peripheral vessels;
- large volume cardiac output blood;
- vasoconstrictor action of catecholamines;
- excess fluid in the body, which increases the load on the heart and blood vessels.
Many pressure medications have a combined effect. These are the drugs latest generation that affect two or more provoking factors (for example, a combination of ACE inhibitors with diuretics and calcium channel blockers).
Principles for the selection of drugs for pressure
The choice of therapy for arterial hypertension is individual. It is made taking into account the age, the mechanism of the development of the disease, as well as the presence of other pathologies in the patient, complicating the course of hypertension. The degree of arterial hypertension also matters.
Development mechanisms:
If the cause of the increase in pressure is bad job kidneys, therapy is aimed at removing excess fluid and normalizing the functioning of the organ. With vascular spasms, antispasmodics and vasodilators are selected.
Hypertension, detected not immediately, inevitably gives complications to other organs. First of all, vision, the brain, the kidneys (if not they were the cause of the disease) and the heart suffer. Medicines are applied taking into account the degree of their defeat.
Medicines against pressure have many undesirable effects and contraindications. Elderly people and children are prescribed taking into account concomitant diseases.
Mechanism of antihypertensive action of drugs of different pharmacological groups
Hypertension is treated with long-acting medications, prescribed in courses or for life. Preparations for continuous use give a cumulative antihypertensive effect and allow you to keep the level of pressure within the target values. The pathogenesis of hypertension determines the use of pressure tablets of the following pharmacological groups:
- blockers (alpha, beta and hybrid);
- calcium antagonists (calcium channel blockers);
- drugs that inhibit the activity of ACE (alphatensin-converting enzyme);
- alpha brain stimulants;
- diuretics;
- antispasmodics;
- sympatholytics.
Beta blockers
Catecholamines (adrenaline and noradrenaline) produced by the adrenal glands are one of the causes high pressure. Adrenoreceptors of the alpha and beta groups react to them. Beta-blockers temporarily block receptors that are sensitive to adrenaline and noradrenaline, due to which the following effect is achieved:
- vessel walls relax and become more permeable;
- improves nutrition of the heart muscle;
- the heart rate stabilizes;
- the heart rate decreases.
Beta-blockers are selective and non-selective. Non-selective act simultaneously on two types of receptors - beta 1 and beta 2. Selective (cardioselective) act selectively only on beta 1 receptors. Not selective drugs have many side effects due to the blockade of two types of receptors.
Beta-blockers are divided into fat-soluble and water-soluble. Fat-soluble foods are absorbed faster, better absorbed and more quickly excreted from the body. Hydrophilic are excreted almost unchanged, but remain in the body longer (have a prolonged effect).
calcium antagonists
Their action is based on blocking the slow channels through which calcium ions enter the cells. Penetrating into them, calcium causes muscle contraction, in particular the vascular walls. When the channels for the current of calcium ions are blocked, the following occurs:
- relaxation of the smooth muscles of the vascular wall;
- coronary arteries expand;
- decreased peripheral vascular resistance;
- the heart muscle needs less oxygen.
As a result, an antihypertensive effect occurs, accompanied by a decrease in afterload on the heart (a decrease in the tension of the walls of the left ventricle). Improves blood supply to the heart by preventing spasm coronary vessels and reduce their resistance.
ACE inhibitors
Alphatensin converting enzyme (ACE) is involved in a complex biochemical reaction that increases blood pressure. ACE inhibitors suppress its activity. They gently reduce pressure, relaxing the vascular wall. Drugs are drugs fast action.
Sartans (angiotensin II receptor blockers)
Patients with increased activity renin (most often in renal pathology). The enzyme is produced by the kidneys and, together with angiotensin and aldosterone, forms a system (RAAS) that affects water-salt metabolism. They retain excess fluid in the body and raise blood pressure. Sartans reduce the sensitivity of angiotensin-II receptors, thus exerting an antihypertensive effect.
Sartans are long-acting medicines belonging to a new generation. They have a minimum of side effects, reduce the risk of developing serious heart and kidney pathologies, and reduce the possibility of diabetes.
Alpha Brain Stimulants
The drugs of this group stimulate adrenoceptors of the brain, reducing tension sympathetic department vegetative nervous system. In addition, they suppress the formed reflexes, destroying cause-and-effect relationships. For example, when the pressure "jumps" in response to certain life situations.
In addition to suppressing the tone of the sympathetic nervous system, alpha-stimulants replace endogenous dopamine (the precursor of adrenaline and noradrenaline) with a false neurotransmitter. They reduce the activity of renin, an enzyme that affects blood pressure, inhibit the synthesis of adrenaline and norepinephrine, and activate the action of the parasympathetic nervous system.
Diuretics
Diuretics are divided into two groups - fast and prolonged action. The former are used as an "ambulance", the latter are part of long-term therapy. "Fast" diuretics have an antihypertensive effect due to:
- removal of excess fluid and sodium chloride;
- decreased sensitivity of smooth muscle vascular system to a vasoconstrictor effect;
- reduction in the volume of circulating fluid.
Long-acting diuretics reduce blood pressure due to a mild diuretic effect. In addition, they relieve swelling, reduce vascular tone and expand them.
Myotropic antispasmodics
If a sharp "take-off" of pressure is provoked by a vascular spasm, myotropic antispasmodics are used. They are also used to treat hypertension early stage. Pressure reduction is achieved by relaxing the smooth muscles of the vascular wall, enhancing the action of other drugs, removing nervous tension and convulsions. Antispasmodics for acute conditions used in combination with drugs that lower blood pressure.
Sympatholytics are called drugs central action, as they affect the vasomotor center of the brain. The antihypertensive effect is expressed as follows:
- the shock (systolic) volume of blood decreases;
- the resistance of distal vessels decreases;
- heartbeat slows down.
Most sympatholytics are used only in cases of severe hypertension when other drugs have failed.
How quickly do antihypertensive drugs work?
The rate of action of drugs depends on the degree of pressure increase, as well as on the patient's body. In addition, the dose prescribed by the doctor and the duration of the course also affect. Drugs in the same group may have different periods assimilation and speed of deployment of the main effect.
| "Fast" diuretics | up to 3 hours | Around 8 o'clock. |
| Long acting diuretics | Unfolds throughout the day with a single dose | Persistent healing effect develops on the seventh day and continues for another 3 days after cancellation. |
| ACE inhibitors, sartans | 24 hours | A persistent antihypertensive effect occurs by the end of the first month and intensifies by the eighth week of treatment. |
| Beta blockers | Individual | A stable effect occurs after 7-14 days. |
| BP figures decrease within 5 hours after taking the tablet form and 3 hours after intravenous administration | With a single dose - up to 10 hours. | |
| Antispasmodics | Within half an hour | Up to 3 hours |
| calcium antagonists | Individual | For different generations of drugs - from 8 to 36 hours. |
Drug Overview
All antihypertensive drugs are constantly being studied and improved. At the same time, scientists strive to minimize contraindications and side effects.
Non-selective drugs:
- Anaprilin;
- Carvedilol;
- Nadolol;
- Penbutolol.
Cardioselective beta-blockers:
- bisoprolol;
- metoprolol;
Contraindications and side effects
Adrenoblockers are prescribed with caution in insulin-dependent diabetes mellitus. This type of disease is dangerous with bouts of hypoglycemia. If you do not take action quickly, a hypoglycemic coma develops within a short time. Adrenoblockers hide the main symptoms of a drop in blood glucose levels - tremor, tachycardia, palpitations. Contraindications:
- heart failure;
- atrioventricular and sinoatrial heart block;
- weakness of the sinus node;
- sinus bradycardia;
- bronchial asthma.
When taken, the following side effects may occur:
- headache and dizziness;
- stool disorders;
- dyspnea;
- weakness and fatigue;
- change in sensation in the lower extremities.
One of the side effects is a decrease in sexual function in men.
calcium antagonists
Today, there are several generations of drugs - calcium channel blockers. Representatives of the latter of them are more bioavailable and are excreted from the body more slowly (and, therefore, they last longer). Today, representatives of all groups are used in practice:
- Amlodipine;
- Nifedipine;
- Felodip;
- Verapamil.
Contraindications and side effects:
- heart failure;
- Severe AV blockade;
- unstable angina;
- pregnancy and lactation;
- children under 18;
- narrowing of the aorta;
- MAC syndrome.
Side effects can include swelling in the arms and legs, heart block, bleeding gums, drowsiness, and a feeling of constant fatigue.
ACE inhibitors
The range of application of ACE inhibitors is wide, for pressure reduction the most popular are:
- Ramipril;
- Captopril (Capoten);
- Lisinopril;
- Perindopril (Prestarium, Perineva);
- Enalapril.
The drugs are safe for diabetic nephropathy, atherosclerosis, myocardial infarction and some other diseases.
ACE inhibitors are contraindicated in children and adolescents under 18 years of age, pregnant and lactating mothers. In addition, they should not be taken by hypertensive patients with the following pathologies:
- severe disorders of the liver and kidneys;
- constriction renal arteries and the mouth of the aorta;
- hypersensitivity to any ACE inhibitors.
Possible side effects:
- increased heart rate;
- taste disorders;
- dry cough;
- muscle weakness;
- changes in the blood - a drop in the level of hemoglobin and leukocytes.
Sartans
- Lozap;
- Losartan;
- Blocktran;
- Kozaar.
Sartans are combined with diuretics with caution. The drugs have minimal contraindications:
- pregnancy and lactation;
- children's age up to 18 years;
- individual intolerance;
- increased levels of potassium in the body.
Diuretics
Rapid-acting drugs include Furosemide and Lasix. For long-term therapy, Veroshpiron, Indapamide (Arifon) and hypothiazide diuretics are used.
Taking diuretics causes the body to lose potassium and magnesium needed for normal operation heart muscle. For the patient, this turns into convulsions. calf muscles most often occurring at night and in the morning. To make up for losses, it is recommended to take Panangin or Asparkam at the same time.
Veroshpiron has a potassium-sparing property, so it is contraindicated in hyperkalemia. Indapamide moderately removes potassium and magnesium.
The drugs in this group include:
- Methyldopa;
- Guanetedine;
- Urapidil;
- Isobarin;
- Oktadin;
- Clonidine.
Centrally acting drugs can be used for rapid decline pressure, as well as long-term maintenance therapy.
Contraindications and side effects
Drugs are rarely prescribed for older people and those diagnosed with kidney failure. Other contraindications:
- unstable angina;
- stroke;
- a history of myocardial infarction;
- pregnancy and lactation.
Side effects:
- dry mouth:
- feeling tired;
- bradycardia;
- temperature rise is possible;
- on the part of the blood - a decrease in the number of platelets and leukocytes.
Antihypertensive drugs "ambulance"
At hypertension 1 degree, when pressure rises are only sporadically, and during hypertensive crises, fast-acting medications are used:
| Furosemide (Lasix) | removes excess fluid and sodium chloride; | Within 1 hour |
| reduces pulmonary pressure and pressure when filling the left ventricle of the heart; | ||
| reduces the sensitivity of vascular smooth muscles to vasoconstrictive effects; | ||
| reduces the volume of circulating blood | ||
| Kapoten (Captopril) | reduces the resistance of peripheral vessels; | Within 30 - 40 minutes |
| dilates blood vessels; | ||
| enhances blood flow in the renal and coronary arteries; | ||
| improves blood flow | ||
| Cordipin (Corinfar, Cordaflex). With a hypertensive crisis, a dosage of 10 mg is used, the tablet must be chewed. | dilates peripheral vessels and reduces their resistance; | 20 minutes |
| renders light diuretic action and moderately excretes sodium | ||
| Nitrates (Sustak, Nitroglycerin, Nitrocor) are used when high blood pressure is combined with an angina attack | relaxes peripheral vessels; | 1 - 1.5 minutes for sublingual application |
| reduces pressure in the pulmonary circulation | ||
| Gemiton (effective in renal genesis of hypertension) | reduces peripheral vascular resistance and minute blood volume; | 24 hours |
| improves renal blood flow | ||
| Magnesia | dilates blood vessels; | Instantly at intravenous administration, in a few minutes when taken orally |
| relieves nervous tension; | ||
| eliminates cramps; | ||
| contributes to the normalization heart rate |
The most suitable drugs to help during hypertensive crisis fast-acting diuretics Furosemide or Lasix are considered. They reduce pressure smoothly, without compromising the vessels of the brain and heart.
Alpha-blockers are another group of ambulance drugs. They act quickly, but not for long. Their danger lies in the high rate of pressure reduction and, as a result, the threat of developing a stroke or myocardial infarction. Most often they are used to reduce pressure, which has risen sharply as a result of severe stress. Alpha-blockers include Prazosin, Doxazosin. Their hypotensive effect lasts no more than 10 hours.
Self-administration of antihypertensive drugs is contraindicated. But even without treatment, hypertension cannot be left. At the first episodes of increased pressure, it is necessary to consult a doctor to prescribe adequate individual therapy.
In this medical article you can see drug Lisinopril. Instructions for use will explain at what pressure tablets can be taken, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.
In the article, doctors and consumers can only leave real reviews about Lisinopril, from which you can find out whether the drug helped in the treatment of arterial hypertension and lowering pressure in adults and children, for which it is also prescribed. The instructions list analogues of Lisinopril, drug prices in pharmacies, as well as its use during pregnancy.
Hypotensive, vasodilating drug is Lisinopril. Instructions for use recommends taking tablets of 2.5 mg, 5 mg, 10 mg, 20 mg with various forms arterial hypertension, diabetic nephropathy, as well as in combination therapy for early treatment acute myocardial infarction and chronic heart failure.
Release form and composition
Lisinopril is supplied in tablets of 2.5 mg, 5 mg, 10 mg, 20 mg. Includes the eponymous active substance and ancillary items.
pharmachologic effect
Lisinopril, instructions for use confirms this, increases the tone of peripheral vessels and promotes the secretion of aldosterone by the adrenal glands. Thanks to the use of tablets, the vasoconstrictive effect of the hormone angiotensin is significantly reduced, while a decrease in aldosterone is noted in the blood plasma.
Taking the drug helps to lower blood pressure, and regardless of the position of the body (standing, lying down). Lisinopril avoids the occurrence of reflex tachycardia (increased heart rate).
A decrease in blood pressure in the process of taking the medication occurs even with a very low content of renin in the blood plasma (a hormone produced in the kidneys).
Drug properties
the effect this drug becomes noticeable within an hour after its implementation oral intake. The maximum effect of Lisinopril is observed 6 hours after administration, while this effect continues to persist throughout the day.
Abrupt discontinuation of this drug does not lead to a rapid increase in blood pressure, the increase may be insignificant compared to the level that was before the start of therapy.
If Lisinopril is used in patients suffering from heart failure, in parallel with digitalis and diuretic therapy, it has next action: reduces the resistance of peripheral vessels; increases the stroke and minute volume of blood (without an increase in heart rate); reduces the load on the heart; increases the body's tolerance to physical activity.
The drug significantly improves intrarenal dynamics. This drug is absorbed from gastrointestinal tract, while its maximum concentration in the blood is noted in the interval from 6 to 8 hours after the administration.
What helps Lisinopril?
Indications for the use of the drug include:
- diabetic nephropathy (reduction of albuminuria in insulin-dependent patients with normal blood pressure and non-insulin-dependent patients with arterial hypertension);
- chronic heart failure (as part of combination therapy for the treatment of patients taking digitalis and / or diuretics);
- arterial hypertension (in monotherapy or in combination with other antihypertensive agents);
- early treatment of acute myocardial infarction (in the first 24 hours with stable hemodynamic parameters to maintain these parameters and prevent left ventricular dysfunction and heart failure).
At what pressure should I take it?
Lisinopril is prescribed for pressure above 140 over 90.
Instructions for use
Lisinopril (indications suggest taking various doses of the drug) is available in tablets containing 2.5 mg, 5 mg, 10 mg and 20 mg of the active substance. The instruction recommends taking Lisinopril once a day, preferably at the same time.
The use of the drug for essential hypertension should be started with 10 mg per day, followed by a transition to a maintenance dose of 20 mg per day, while last resort, a maximum daily dose of 40 mg is allowed.
Reviews about Lisinopril indicate that the full therapeutic effect drug may develop 2-4 weeks after the start of treatment. If after applying maximum doses the drug did not achieve the expected results, it is recommended additional reception other antihypertensive drugs.
Patients taking diuretics should stop taking them 2-3 days before the start of Lisinopril. If for some reason the abolition of diuretics is not possible, daily dose Lisinopril should be reduced to 5 mg.
In conditions with increased activity of the renin-angiotensin-aldosterone system, which regulates blood volume and blood pressure, the instruction recommends using Lisinopril in a daily dose of 2.5-5 mg. The maintenance dose of the drug for such diseases is set individually, depending on the magnitude of blood pressure.
How to take in diseases
At kidney failure The daily dose of Lisinopril depends on creatinine clearance and can vary from 2.5 to 10 mg per day.
Persistent arterial hypertension involves taking 10-15 mg per day for a long time.
Taking the drug in chronic heart failure begins with 2.5 mg per day, and after 3-5 days increase to 5 mg. The maintenance dose for this disease is 5-20 mg per day.
In diabetic nephropathy, Lisinopril is recommended to take 10 mg-20 mg per day.
Application for acute infarction myocardium involves complex therapy and is performed according to the following scheme: on the first day - 5 mg, then the same dose - once a day, after which the amount of the drug is doubled and taken once every two days, the final stage is 10 mg once a day . Lisinopril, indications determine the duration of treatment, in acute myocardial infarction take at least 6 weeks.
Contraindications
Side effects
- alopecia;
- angioedema (face, lips, tongue, larynx or epiglottis, upper and lower extremities);
- anorexia;
- anuria;
- asthenic syndrome;
- stomach ache;
- chest pain;
- pronounced decrease in blood pressure;
- headache;
- dizziness;
- diarrhea;
- dyspepsia;
- taste changes;
- myocardial infarction;
- skin rash;
- skin itching;
- hives;
- mood lability;
- leukopenia, neutropenia, agranulocytosis, thrombocytopenia;
- fever;
- myalgia;
- violation of the development of the fetus;
- impaired renal function;
- impaired renal function;
- heart rhythm disturbances;
- oliguria;
- orthostatic hypotension;
- acute renal failure;
- increased fatigue;
- increased sweating;
- heartbeat;
- weakness;
- decrease in potency;
- drowsiness;
- confusion;
- convulsive twitching of the muscles of the limbs and lips;
- dry cough;
- dry mouth;
- tachycardia;
- nausea, vomiting;
- cardiopalmus;
- cerebrovascular stroke in patients with increased risk diseases due to a pronounced decrease in blood pressure.
Children, during pregnancy and lactation
The drug is not prescribed to persons under 18 years of age. Contraindicated during pregnancy and breastfeeding.
special instructions
In acute myocardial infarction, the drug is used against the background of complex therapy with the use of thrombolytics, beta-blockers and acetylsalicylic acid.
Before surgical intervention the doctor should be warned about taking Lisinopril. Patients with diabetes require regular monitoring of sugar levels.
drug interaction
In combination with drugs containing lithium, the excretion of the latter from the body is disrupted. With this combination, constant monitoring of the concentration of lithium in the blood is required.
Lisinopril enhances the effect of ethanol. Non-steroidal anti-inflammatory drugs, estrogen and acetylsalicylic acid reduce the antihypertensive effect of the drug.
Analogues of the drug Lisinopril
According to the structure, analogues are determined:
- Liten.
- Lisinoton.
- Prinivil.
- Lysonorm.
- Sinopril.
- Lisinopril dihydrate.
- Dapril.
- Lysigamma.
- Lisinopril Grindeks (Stada, Pfizer, Teva, OBL, Organika).
- Listril.
- Irumed.
- Lizoril.
- Rileys Sanovel.
- Diroton.
- Lizacard.
- Diropress.
In combination with hydrochlorothiazide:
- Skopril plus.
- Liten N.
- Listril Plus.
- Iruzid.
- Rileys Sanovel plus.
- Co-Diroton.
- Lysoretic.
- Lisinopril N.
- Zonicsem ND.
- Lisinoton N.
- Zoniksem NL.
In combination with amlodipine:
- Equator.
- Ekvakard.
Holiday conditions and price
The average price of Lisinopril (tablets 10 mg No. 30) in Moscow is 44 rubles. In Kiev, you can buy medicine for 45 hryvnia, in Kazakhstan - for 1498 tenge. Pharmacies in Minsk offer medicine for 2-3 bel. ruble. It is released from pharmacies by prescription.
To lower blood pressure, Lisinopril and Bisoprolol are prescribed simultaneously. Both drugs are used in the treatment cardiovascular diseases. Means are well combined and have more pronounced effect at joint application. During treatment, the dosage must be observed in order to avoid sharp decline pressure.
Bisoprolol belongs to the group of beta-blockers. The drug increases blood flow to the heart, reduces the heart's need for oxygen, restores heart rhythm and reduces overall peripheral vascular resistance. The agent reduces pressure to normal indicators within 2-3 hours after ingestion. The action lasts up to 24 hours.
How Lisinopril works
Lisinopril is an ACE inhibitor. The drug prevents the formation of angiotensin 2 from angiotensin 1. As a result, the vessels dilate, the pressure decreases to the normal level, the heart muscle is better able to tolerate physical activity. Provides rapid and complete absorption of the active substance. After taking it, the risk of developing severe cardiovascular complications decreases. The effect is observed within 1 hour and lasts up to 24 hours.
The combined effect of bisoprolol and lisinopril
Pressure pills restore the functioning of the heart muscle. In complex therapy, the effectiveness increases and the risk of developing myocardial hypertrophy and other consequences of hypertension decreases. Regular use helps to achieve a more stable and long-lasting result.
Indications for simultaneous use
Reception is indicated for chronic heart failure and hypertension. May additionally require the use of diuretics or cardiac glycosides.
Contraindications to bisoprolol and lisinopril
It is contraindicated to start treatment for certain diseases and conditions, including:
- pregnancy;
- breastfeeding period;
- spontaneous angina;
- increased levels of thyroid hormones in the blood;
- metabolic acidosis;
- allergy to drug components;
- low pressure;
- post-infarction condition;
- the presence of pheochromocytoma;
- Raynaud's disease at an advanced stage;
- rebound arterial hypertension;
- bronchial asthma in a severe stage;
- decrease in heart rate;
- violation of the formation or strength of the impulse in the sinus node;
- cardiogenic shock;
- acute heart failure;
- Quincke's edema in history;
- hypertrophic cardiomyopathy with impaired blood flow through the vessels;
- narrowing of the opening of the aorta, renal arteries, or mitral valve;
- excessive secretion of aldosterone;
- children's age up to 18 years;
- use with preparations containing Aliskiren;
- impaired renal function with creatinine levels less than 220 µmol/l;
- congenital intolerance to galactose;
- lactase deficiency.
During therapy, it is forbidden to carry out hemodialysis using high-flow membranes.
How to take bisoprolol and lisinopril
Tablets should be taken orally, without chewing and with a small amount of liquid. Recommended dosage of bisoprolol and lisinopril for arterial hypertension- 5 mg 1 time per day. With good tolerance, the dosage can be gradually increased. In renal insufficiency, the dosage should be reduced to 2.5 mg.
In chronic heart failure, the initial dosage is 1.25 mg of bisoprolol and 2.5 mg of lisinopril. The dosage is increased gradually.
For diabetes
At high blood pressure against the background of non-insulin dependent diabetes mellitus, 10 mg of Lisinopril and 5 mg of Bisoprolol are taken.
Side effects
During therapy, side effects may occur:
- dry cough;
- angioedema;
- lowering blood pressure;
- chest pain;
- cardiopalmus;
- increased fatigue;
- muscle cramps;
- bronchospasm;
- decrease in the number of leukocytes and platelets in the blood;
- anemia;
- bradycardia;
- indigestion;
- inflammation of the pancreas;
- abdominal pain;
- skin rashes and itching;
- dysfunction of the kidneys and liver;
- increased levels of potassium and sodium, creatinine, urea and liver enzymes in the blood;
- muscle pain;
- headache;
- dizziness;
- depressive state;
- hearing loss;
- gagging;
- nausea;
- constipation;
- erectile dysfunction.
Quite an inexpensive drug, actively used in modern medicine, bears the name "Bisoprolol". What are these pills for? The most accurate answer to this question is given by the instructions for the use of the drug, which is necessarily present in the package. However, if there is a desire to deal with this information without purchasing a medication, then this material is at your service.
"Bisoprolol": what are these pills from?
The drug was developed for use in arterial hypertension and heart attack, it also provides important assistance in coronary disease heart, chronic heart failure (CHF), angina pectoris, heart complications after a sore throat. As a rule, it is prescribed if there are violations of the heart rhythm with extrasystole, arrhythmia, thyrotoxicosis.
Analogues of "Bisoprolol" on sale are presented in quite great variety. Drugs with the same name, but different manufacturers are quite different in price. The designations of the manufacturer can be added to the name: "Teva", "Vertex", "Northern Star". Depending on the number of tablets in the package, the characteristics of the composition, the manufacturer, one package costs from 20 to 200 rubles.
Is it possible to replace the drug with an analogue?
Analogues of "Bisoprolol" on sale are represented by the following names:
- "Biprol".
- "Bidop".
- Biol.
Some of them are sold at an affordable cost, like the drug in question, others are more expensive. If the doctor advised to use Bisoprolol, the effect of this drug will be greater than that of analogues. Replace tool with similar drugs(generics) is possible only with the consent of the attending physician. Self-replacement of one drug with another is categorically not recommended, especially from the point of view of the budget there is no benefit, and the tolerance of the body of "Bisoprolol" is better than many analogues.
How to use?
"Bisoprolol" belongs to the group of selective beta1-blockers. The tool is available in the form of tablets, each of which has a shell - a thin film that facilitates administration.
How to take "Bisoprolol" is described in detail in the instructions that come with the drug. It is usually drunk in the morning before breakfast. empty stomach. The entire daily dose is used at a time, swallowed immediately, without chewing. As a rule, from 5 to 10 mg are prescribed per day. The daily dose of "Bisoprolol" for an adult should not be more than 20 mg. Special conditions are designed for those diagnosed with kidney and/or liver problems (maximum daily dose is halved to 10 mg).
Application features
According to the instructions, "Bisoprolol" is recommended to be taken starting with a dose of 1.25 mg per day (for CHF treatment). It is kept throughout the first week of treatment. On the second week, the concentration is increased to 2.5 mg, after another week it is increased again, and the daily dose reaches 3.75 mg. Then for several weeks (from the fourth to the eighth), 5 mg are taken every day in the morning, and from the ninth to the twelfth - 7.5 mg. The next step is 10 mg in 24 hours. This dose is kept until the doctor recommends that the course of treatment be completed. The tool is designed for long-term therapy, often used for years, sometimes it is prescribed for lifelong use.
If during the treatment with "Bisoprolol" (according to the instructions) the patient noticed an improvement in the condition, the course should not be interrupted without the consent of the attending physician. You can check with the doctor whether it is realistic to stop treatment, but it is strictly forbidden to stop taking it without the consent of a specialist. The condition can not only return to the one that was before the start of therapy, but also become noticeably harder.
Diagnoses: when is "Bisoprolol" not prescribed?
Contraindications to the use of "Bisoprolol" include the following pathologies:
- bradycardia;
- chronic obstructive pulmonary disease (COPD);
- cardiomegaly;
- hypotension;
- cardiogenic shock;
- severe form of peripheral circulatory disorders.
Also, the product is not used during the feeding period. baby and when using monoamine oxidase (MAO) inhibitors, if they do not belong to the MAO-B group.
How it works?
As follows from the instructions for "Bisoprolol" (reviews confirm this), the remedy has a strong hypotensive effect, helps fight arrhythmia. The drug acts selectively and belongs to the class of beta1-blockers. It affects the beta1 receptors in the cardiac system, but at a relatively low dose, due to which the activity of catecholamines is inhibited, the generation of ATP and cAMP is reduced, and calcium metabolism slows down. The drug slows down the heart rate by inhibiting excitability and the ability of the myocardium to contract.
Features of efficiency: what else is important?
Confirm the effectiveness of hypertension "Bisoprolol" reviews, which in in large numbers published on the World Wide Web. As the manufacturer explains, the positive effect is due to a reduction in the minute volume of blood circulation. In addition, active active substance the drug stimulates peripheral vessels, the renin-angiotensin-aldosterone system is inhibited. Baroreceptors under the influence of "Bisoprolol" become more sensitive. With hypertension, the primary effect can be observed a few days after the start of treatment (but no later than five), and stabilization of the patient's condition is observed after one or two months from the start of treatment.
The effect that eliminates complications on the heart after a sore throat is also confirmed by reviews of "Bisoprolol". As the manufacturer explains, the effectiveness is guaranteed by the fact that under the influence active component the myocardium receives the necessary amount of oxygen, as the heart rate decreases, diastole becomes longer, myocardial perfusion is better. Diastolic pressure rises, the muscle fibers in the ventricles of the heart stretch more efficiently.
"Bisoprolol" for arrhythmia: proven effectiveness
Considering the testimony of "Bisoprolol", one cannot lose sight of the arrhythmia. The effectiveness of taking the medication in patients with this disorder is ensured by suppressing the factors that provoke the corresponding state of the body with the drug. Spontaneous arousal becomes almost impossible.
The drug stands out favorably against the background of non-selectively acting beta-blockers, since the side effects of "Bisoprolol" on other organs are much less at an average therapeutic dose. First of all, this applies to those systems where there are beta2-adrenergic receptors. Also declining Negative influence on carbon and sodium metabolism (the latter does not accumulate in the body).
Side effects of "Bisoprolol"
Side effects are rare (1 in 100 patients). As follows from the reviews about the drug, patients rarely experience such troubles, on average, the tolerance of the drug is good. At the same time, you need to be prepared for side effects and at the first manifestations of a deterioration in the condition, you should immediately contact your doctor.
In some patients, when using "Bisoprolol", fatigue increases, sleep and vision disturbances are observed, and pain in the eyes appears. Perhaps the development of sinus bradycardia, a decrease in pressure. Relatively often you can hear complaints about dry mucous membranes. oral cavity and stool problems. If the drug is used in a very large dose, there is a risk of developing difficulty in breathing. With diabetes, the likelihood of hyperglycemia, hypoglycemia increases (depending on the type of disease). Very rarely seen allergic reactions manifested by urticaria or skin itching, a rash may occur. When using the drug during pregnancy, there is a possibility of a delay in the development of the fetus. In some cases, the so-called withdrawal syndrome was diagnosed, when angina pectoris worsened at the end of the course of treatment. Also, in rare cases, there was a decrease in potency.
Application specifics
When choosing "Bisoprolol" it is necessary to regularly monitor the patient's condition. It is important to monitor heart rate, pressure. At the beginning of the use of "Bisoprolol", the indicators are checked every day, with good tolerance, the patient's condition can be monitored every 3-4 months. It is recommended to regularly undergo an ECG, with diagnosed diabetes, donate blood for glucose at least once every 4 months. In the treatment of "Bisoprolol" in the elderly, it is recommended to monitor kidney function, the corresponding analysis is given three times a year. If the drug is used to treat CHF at an initial dosage of 1.25 mg, body readings should be taken for the first four hours. The manufacturer recommends monitoring blood pressure, heart rate, taking ECG readings.
For the most effective control of his condition, a patient treated with "Bisoprolol" should be able to calculate the heart rate himself. If the value is less than 50 beats per minute, you should immediately consult your doctor.
What else to pay attention to?
Despite the indications of "Bisoprolol", in some cases, with angina pectoris, the remedy does not have the proper effectiveness. This is due to the specifics of the disease: it is known that all drugs from the group of beta-blockers do not give a result in approximately every fifth patient. Typically, this is due coronary atherosclerosis at which there is a low ischemic threshold. The effectiveness of the drug decreases if a person has been smoking for a long time, as well as with impaired subendocardial blood flow.
Before prescribing Bisoprolol, the doctor checks the functions external respiration in patients with burdened bronchopulmonary anamnesis. If the patient is using contact lenses, it must be remembered that the use of "Bisoprolol" in some cases provokes a decrease in the release of lacrimal fluid. With an established pheochromocytoma, there is a possibility specific shape hypertension, if it was not possible to achieve effective alpha-blockade. When choosing in favor of "Bisoprolol" for the treatment of patients with diagnosed thyrotoxicosis, it must be remembered that the drug cannot be abruptly canceled.
Compatibility with other drugs
It is known that the compatibility of "Bisoprolol" and products containing clonidine allows the use of these drugs simultaneously, but it is unacceptable to cancel both medications at the same time. First stop taking one drug, and after a few days - the second. When using drugs that reduce the volume of catecholamines, the effectiveness of beta-blockers may increase. It is necessary to inform the doctor about all medicines prescribed by other specialists. The doctor must regularly monitor the patient's condition, otherwise the likelihood of hypotension, bradycardia increases.
The tool can be used for diabetes. The drug does not affect hypoglycemia in most cases, but with the development of tachycardia provoked by this factor, regular intake of "Bisoprolol" can mask the symptoms. The medication in question does not prevent the restoration of blood glucose to normal levels.
Reviews: what do patients say?
On the Internet there are mostly positive reviews about "Bisoprolol". The drug is inexpensive and helps to stabilize the patient's condition even with serious illnesses, if it is used as prescribed by the attending doctor and with regular monitoring of the condition. Mostly negative responses are caused either by self-administration of the drug without the help of a specialist, or intolerance of the body associated with individual characteristics. Also, some patients noted the difficulty of combining the active ingredient "Bisoprolol" with substances present in other drugs. Such an interaction makes it necessary to use the drug only if there is a recommendation from the attending physician who knows which drugs the patient is taking.
At the same time, there are also reviews about "Bisoprolol", which say that the remedy in a particular case was ineffective. As the manufacturer notes, this is possible in every fifth case and is due to other health disorders or individual characteristics. You need to be prepared for such a situation.
For many years now, cardiovascular diseases have been holding the palm among diseases that often lead to death. Moreover, stroke and heart disease are getting younger year by year.
The main risk factors are malnutrition, stress, physical inactivity, tobacco and alcohol use.
The danger of the disease is that it can for a long time not to make themselves felt, but to manifest spontaneously. People with CVD need early diagnosis and treatment through medication.
Doctors are increasingly prescribing for the treatment heart disease drugs or bisoprolol. What is better and what is the difference between these drugs? To resolve this issue, it is necessary to study the composition of both medicines.
Bisoprolol and Concor are drugs from the group of beta-blockers that are widely used to treat hypertension and cardiovascular diseases: heart failure; ischemic heart disease; heart rhythm disturbances; prevention of angina attacks.
Tablets Concor
Concor and other bisoprolol preparations have significant advantages that have made them very popular among patients and doctors.
Compound
The composition of medicines includes the main active ingredient - bisoprol. That is why they act almost the same. Their efficiency is on the same level.
Bisoprolol tablets
Contraindications for use and side effects are also similar. So what is the difference between Concor and Bisoprolol? They differ only in the manufacturer and price. Bisoprolol is domestic analogue Concora. Comparing Concor or Bisoprolol, the price difference is very significant. The Russian drug is somewhat cheaper than its foreign counterpart.
Advantages
P The advantage of drugs over other drugs is in the following points:
- It is enough to take Concor and Bisoprolol 1 time per day. One tablet will provide the patient with stable blood pressure for a day;
- medication does not depend on food intake;
- these beta-blockers have fewer side effects than their predecessors;
- medicines do not affect potency in men;
- affordable price.
- Bisoprolol and Concor are metabolically neutral drugs. They do not affect the metabolism of cholesterol, triglycerides and blood glucose. They are safely prescribed to patients with type 2 diabetes and the elderly.
And yet, many patients are concerned about the question: Bisoprolol and Concor - which is better? Some patients benefit from the more expensive original Concor, while others may rely solely on their health. domestic medicine. The choice of drug for treatment remains with the patients.
How do hypertension medications work?
The drugs under consideration for hypertension are much more stable than other medicines and keep blood pressure at the right level.
Daily pressure monitoring showed that after taking Bisoprolol or Concor tablets, the pressure remains normal in the morning of the day following the intake.
Other beta-blockers reduced or completely stopped their hypotensive effect 4 hours before taking the next dose of the drug.
These medications allow you to effectively control blood pressure and heart rate, not only at rest, but also during physical activity. In this regard, they act better than, for example,. The most important feature drugs are the stability and uniformity of their action during the day.
With severe hypertension, combinations of bisoprolol with other drugs are prescribed. therapeutic agents: diuretics, ACE inhibitors, other drugs for hypertension. It was found that the effect of Concor and Bisoprol on lowering blood pressure remained stable for 3 years while the study was ongoing.
Medicines, even without combination with other medicines, provide the desired effect in patients suffering from mild or moderate hypertension.
Treatment of chronic heart failure
Both drugs are useful in chronic heart failure of various origins.
The drugs significantly reduce the risk sudden death, readmission rates, and improve the quality of life of patients.
At the slightest ailment associated with an increase in blood pressure, such as frequent headaches and dizziness, flies flashing before the eyes, as well as when aching or stabbing pains in the sternum, shortness of breath, it is important to consult a doctor in time.
Timely access to a doctor will significantly reduce the risk of stroke and heart attack.
How to take beta blockers correctly?
At various diseases and depending on the condition of the patient, the dosage of drugs may be different:
- with hypertension, the initial dose is 5 mg per day, gradually increasing it to 10 mg per day;
- in coronary heart disease, the dosage is from 2.5 to 10 mg per day. It is selected strictly individually until the pulse rate reaches 50-60 beats per minute;
- in chronic heart failure, drugs are prescribed in addition to therapy with diuretic drugs and ACE inhibitors. The initial dose is 1.25 mg per day.
For elderly patients, the dosage of drugs is prescribed on a general basis. Treatment of heart disease with beta-blockers and their dosage can only be prescribed by a doctor!
Concor: benefits and harms during pregnancy and lactation
It is Concor that is most often prescribed to expectant mothers for the treatment of arterial hypertension.
Any beta-blockers reduce blood flow in the placenta, and this negatively affects the development of the unborn baby.
After the birth of a child, it must be carefully examined. The newborn may experience symptoms of bradycardia and hypoglycemia.
The active ingredient in Concor breast milk does not stand out, but its use during feeding the baby is not recommended. If you still need to take the medicine, then the doctors insist on giving up breastfeeding.
The interaction of alcohol and bisoprolol
Alcoholic beverages can affect the work of any medication.
This is due to the fact that both alcohol and drugs undergo a processing procedure in the liver, and this negatively affects its work.
Bisoprolol and Concor with reception alcoholic beverages combination is prohibited.
During their interaction, the functioning of the heart is disrupted. This results in arrhythmia and pain in the region of the heart. Alcohol can significantly increase blood pressure. Even a small dose of alcohol during therapy can cause sedation: feeling of emotional depression, severe lethargy.
The simultaneous use of alcohol and beta-blockers can be fatal!
Analogues
Many analogues of these drugs are available on the pharmacy market:
- Biprol;
- Bisogamma;
- Niperten;
- Bisoprolol-Lugal;
- Bisoprolol-Prana;
- Bisoprolol-ratiopharm.
Each manufacturer of Bisoprolol analogues is trying to convince doctors that it is their drug that corresponds international standards quality and in its action is not inferior to the original Concor.
Every doctor has his own opinion on this matter. When prescribing a drug, he focuses on practical experience and the patient's condition.
Contraindications
The list of contraindications for both drugs is almost the same:
- cardiogenic shock;
- bradycardia;
- atrioventricular block II and III degree;
- sick sinus syndrome;
- hypotension;
- hypersensitivity to beta-blockers;
- diseases respiratory tract, emphysema, severe forms bronchial asthma.
Beta-blockers are prescribed with caution in hepatic and chronic renal failure, myasthenia gravis; violations at work thyroid gland, diabetes mellitus; depression, psoriasis.
Side effect
Bisoprolol and Concor are much better tolerated by patients than older generation beta-blockers.
Side effects when taking beta-blockers are still possible and they manifest themselves in the following:
- from the side of the central nervous system: weakness, fatigue, dizziness, headaches, nightmares, anxiety;
- from the senses: vision problems, conjunctivitis, dry and sore eyes;
- from the side of cardio-vascular system: bradycardia, palpitations, cardiac arrhythmias, arterial hypotension;
- from the side digestive system : nausea, abdominal pain, constipation or diarrhea;
- from the side endocrine system: weakening of thyroid function;
- allergic reactions: rash, urticaria, skin itching.
When taking medications, changes in blood test parameters are possible: thrombocytopenia, increased activity of ALT liver enzymes, as well as bilirubin levels.
Related videos
Specialist on which is better: Concor ilm Bisoprolol, what is the difference between the drugs:
Bisoprolol and Concor are modern selective drugs from the group of beta-blockers. They have proven high efficacy in the treatment of hypertension and cardiovascular disease. Side effects are relatively rare, well tolerated by patients. These medications lower blood pressure to right level, reduce the frequency of angina attacks and manifestations of heart failure. Timely treatment with beta-blockers prescribed by a doctor will reduce the risk of stroke and heart attack. The difference between Concor and Bisoprolol is only in the manufacturer and price. Bisoprol is a domestic drug. In Russia, it is included in the Federal program of preferential drug supply sick.
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