The drug "Ranitidine": indications for use, composition and properties. Medicinal reference book geotar

Ranitidine is a highly effective antiulcer medicine, the main function of which is to reduce the production of gastric juice.

The medicine is produced in the form of tablets, packaged in special blisters and cardboard boxes. Each blister contains 10 tablets. One cardboard package can contain 2 or 10 blisters.

One tablet consists of the main component - hydrochloride (150 mg) and additional substances, which are: microcrystalline cellulose, lactose, sodium starch (glycolic), maize starch, magnesium stearate, povidone K-30, colloidal silicon dioxide.

Indications for use

The drug is effective solution eliminate many problems, including:

formation of twelve ulcers duodenum;
prophylaxis after healing of ulcerative formations in duodenum;
presence of hypersecretory pathological conditions, which include systemic mastocystosis, Zollinger-Ellison syndrome and others;
the presence of a benign active ulcer in the stomach;
erosive esophagitis.

The medicine is also used as a prophylaxis after healing of ulcers in the stomach.

pharmachologic effect

The drug is an H2-blocker histamine receptors parietal type cells that are found in the gastric mucosa. Its action is aimed at optimally stimulating and reducing the production of hydrochloric acid.

The following factors influence the increase in hydrochloric acid production: load digestive tract, the influence of biogenic stimulants and hormones.

The drug can significantly reduce the quantitative production of gastric juice, and therefore the hydrochloric acid that is contained in it.

Also, due to its effect, the pH of the stomach contents increases, which leads to a decrease in pepsin activity.

Instructions for use

The single dosage of the drug is determined solely on an individual basis. For adults it usually looks like this:

0.15 g twice a day. Should be taken in the morning and before bedtime. It is also possible to take 0.3 g of the drug in the evening. The duration of the course is four to eight weeks.
As a preventative measure (after the disease has been cured), the medication should be taken daily for twelve months (0.15 g per dose).
If you have Zollinger-Ellison syndrome, you should take 0.15 g at least three times a day. If the disease is in acute stage, then this dose, if necessary, can be increased to 0.9 g per day.

Patients from 14 to 18 years old take the medicine 0.15 g twice a day. In the presence of renal failure, the dosage should be reduced to 0.075 g and taken twice a day.

The dosage of the drug is determined depending on the complexity of the disease:

The presence of acute ulcerative formations in the duodenum and stomach - 150 mg twice a day or a single dose of 300 mg before bedtime. The duration of treatment is four to eight weeks, but if the problem is not completely resolved within this period, then the course is extended for another four weeks.
Prevention of relapse - no more than 150 mg before bedtime.
Smoking patients - no more than 300 mg at bedtime.
Presence of NSAIDs - gastropathy, no more than 150 mg twice a day or 300 mg in one dose before bedtime. Treatment lasts eight to twelve weeks.
The presence of reflux-esophagitis of the erosive type - no more than 150 mg twice a day or 300 mg in one dose before bedtime. Treatment lasts eight weeks. If a severe form of the disease of the second or third degree is detected, the dosage is increased to 600 mg. Take four times a day for twelve weeks.
The presence of Zollinger-Ellison syndrome - the initial dosage is no more than 150 mg three times a day. If the disease is chronic, then the medicine should be taken 150 mg twice a day for six weeks.
Treatment of small patients with peptic ulcers is carried out at 2-4 mg/kg twice a day. For reflux esophagitis - no more than 8 mg/kg three times a day. Important: maximum daily dosage for a child should not exceed 300 mg.

What is the difference between Ranitidine and Ranitidine Akos? The differences relate to the composition, since the second option, in addition to the “standard” set of components that are included in Ranitidine, contains the following substances: corn starch, calcium gluconate, propylene glycol, talc and hypromellose.

In addition, the action of the drug is aimed at eliminating acute forms ulcerative diseases and complex cases that Ranitidine cannot cope with, since its action is aimed at eliminating “fresh” and shallow ulcers.

Contraindications and side effects

Under no circumstances should you use this drug those people who have allergic reactions to any component of Ranitidine.

It is also unacceptable to use the drug in patients who suffer from severe liver disease or have malignant neoplasms.

Concerning side effects from the medication, the following negative manifestations may occur:

malaise, drowsiness, dizziness, insomnia, hallucinations, depression, impaired consciousness and visual perception;
development of tachycardia, atrioventricular block, bradycardia, ventricular premature strokes;
diarrhea, constipation, vomiting, nausea, painful sensations in the abdominal area, pancreatitis;
hepatitis mixed and cholestatic type, jaundice;
myalgia, arthralgia;
granulacytopenia, leukopenia, aplastic anemia;
appearance skin rash, alopecia, erythema, anaphylaxis, angioedema.

Application for children

The use of this medicine for children is permissible only if healing process will be carried out under the supervision of a doctor.

Pregnant and breastfeeding women are not recommended to use the product, as its components may pass into milk.

It can only be taken if the doctor is confident in the safety of the fetus.

special instructions

Before you start taking the drug, you need to make sure that there are no malignant neoplasms, since it can “hide” symptoms indicating gastric carcinoma. You should not suddenly stop using the drug, as the development of the so-called rebound syndrome may begin.

In case of prolonged treatment course in patients who are exposed to systematic stressful situations, the infection may spread.

Ranitidine can cause porphyria, which is accompanied by acute short-term attacks. During the period of use, you must refrain from activities that require increased alertness and concentration.

May reduce the skin's response to histamine and cause inaccurate results.

When using the drug, you should refrain from consuming drinks, food and other drugs that can cause irritation of the stomach, namely its mucous membrane.

Drug interactions

If it is necessary to treat Ranitidine together with antacids, it is important to adhere to a strict interval between their immediate doses. The break is one to two hours.

Analogs

The main synonyms of the drug are: Gi-kar, Zantac, Acyloc-E, Ranitab, Apo-Ranitidine, Peptoran.

Drug price

The cost of Ranitidine ranges from 12 to 64 rubles, depending on the number of tablets.

Ranitidine is an antiulcer, antisecretory drug. Thanks to the medicine, histamine H-2 receptors, which are located in the gastric mucosa, are blocked. The drug can relieve heartburn. When is it appointed? complex therapy for many gastrointestinal diseases. This medication is especially necessary for bedridden patients who suffer from impaired swallowing reflex and diseases gastrointestinal tract.

Composition and release form

Release form

The medicine is available in tablets. One tablet may contain 150 or 300 mg of active substance. The package contains 10,20,30, 100 tablets. For injections, 2 ml ampoules are available.

Composition of the medicine

One 150 mg film-coated tablet contains ranitidine in the hydrochloride form. With excipients: microcrystalline cellulose, croscarmellose sodium, colloidal silicon dioxide, magnesium stearate. The shell consists of hypromellose, triacetin, titanium dioxide E171, talc.

One film-coated tablet contains 300 mg, in addition to everything listed above, the presence of brownlac dyes. The tablet form of the drug 150 mg is doubly convex, white-yellowish- white, with a characteristic odor. 300 mg tablets have a pale pink color and a characteristic odor.

pharmachologic effect

While taking the medicine, there is a decrease in basal and stimulated secretion of hydrochloric acid, which occurs due to irritation of barroreceptors, food loads, the action of hormones and biogenic stimulants. The medicine lasts for about 12 hours. It is available only in film-coated tablets of 150 mg, which dissolve after taking it in the stomach.

Ranitidine solution is used for injection. If a patient comes to the doctor with chronic diseases in the heart area, with porphyria, diseases associated with the kidneys, with the liver, then he must definitely talk about it. The doctor has an individual approach to the use of the drug for each patient. Do not forget that the drug is eliminated by the kidneys, so if their functioning is impaired, the doctor will then be able to prescribe a small dose of the drug. You should not take the drug yourself. In any case, consultation with a specialist is necessary.

Indications for use of Ranitidine

For illnesses, as well as preventive measures associated with exacerbation of gastric and duodenal ulcers.
In case of inflammation of the esophagus, if the integrity of its mucous membrane is compromised, when gastric contents are thrown into the esophagus. Reflux-esophagitis, erosive esophagitis. Take: 150 mg twice every 24 hours. If the exacerbation is 4 times, from 1 to 2 months.
Zollinger-Ellison syndrome. When a patient has a combination of a stomach ulcer and a benign tumor in the pancreas.
During treatment and preventive measures postoperative gastric ulcer.
For preventive measures associated with recurrent bleeding of the upper gastrointestinal tract.
For prophylaxis, if gastric juice gets into Airways, during surgery under anesthesia, aspiration of gastric juice. 2 hours before anesthesia 150 mg and before surgery in the evening 150 mg. If there associated disorder liver, then the dose is underestimated. In case of renal failure, creatinine clearance is less than 50 ml/min, it is necessary to take the drug in an amount of 150 mg per day.

What does Ranitidine help with, what diseases?

According to the instructions for use, it is used both in preventive measures and in treatment. The doctor prescribes medicine to the patient if there is:

Gastritis
Stomach ulcer
12 duodenum
Zollinger-Ellison syndrome,
Gastroesophageal reflux,
Heartburn.

Gastric juice and hydrochloric acid decrease in volume. Stomach acidity decreases and pepsin activity decreases. The gastric mucosa improves, providing the prerequisites for the healing of ulcers.

Contraindications

Expectant mothers should not take Ranitidine. At breastfeeding. Children under 12 years old. Patients with hypersensitivity to the drug. You should not consume food, drinks or medications that have a negative effect on the gastric mucosa. Also, it is not prescribed in case of hypersensitivity to the drug and its components.

Side effects

Ranitidine is one of those drugs that can cause side effects when used. During administration, side effects may occur related to the nervous, cardiovascular systems, gastrointestinal tract, and skin rashes. Rarely, the patient may feel: headache, fatigue. In seriously ill patients, the drug may cause drowsy state, dizziness, insonomia, vertigo, depression. In rare cases, after taking the drug, disturbances associated with confusion, hallucinations, reversible blurred vision, and impaired eye accommodation may occur.

A person can feel: arrhythmia, tachycardia, bradycardia. You may also feel a bad condition in the gastrointestinal tract: nausea, vomiting, constipation, diarrhea. If you take the drug in large doses (more than 450 mg per day), then in men the mammary glands may begin to enlarge and impotence will appear. Patients of both sexes will experience a decrease in libido. Women will experience menstrual irregularities.

Instructions for use

Method and dosage of tablets

1 tablet 150 or 300 mg contains: Ranitidine hydrochloride. Auxiliary components: microcrystalline cellulose, corn starch, collidon IA-64, colloidal silicon dioxide, magnesium stearate, hypromellose, ethylcellulose, polyethylene glycol, 6000, propylene glycol, sodium lauryl sulfate, titanium dioxide, sunset yellow dye.

The medicine is taken both before and after meals, washed down with water. large quantities. There must be a doctor's recommendation. He prescribes the dose of medicine, duration of treatment and additional medications, for example, to neutralize the acidity of gastric juice, he will prescribe an antacid drug. The tablets are not chewed and are washed down with plenty of water. Also produced effervescent tablets. One tablet requires a glass of water to dissolve it. After it is completely dissolved, the solution can be drunk.

Method and dosage of injections

Ranitidine solution for parenteral administration manufactured in ampoules. The injection into the vein is done slowly over 5 minutes. Dilute the drug with 0.9% sodium chloride solution or 5% dextrose. The dropper is placed for 2 hours at a rate of 25 mg/hour. An injection is given into the muscle 3 to 4 times a day. Injections can be taken by children over 14 years of age and adults. The attending physician decides how many days to give injections. Everything will depend on the severity of the disease. Injections are prescribed: for stomach ulcers, peptic ulcer 12 duodenal ulcers, for stress and symptomatic ulcers. Injections are strictly prohibited for patients with hypersensitivity to the contents of the drug. It is very important to keep track of the time between injections.

Ranitidine for gastric and duodenal ulcers

If the patient has a peptic ulcer of the stomach and duodenum, then take 1 150 mg tablet in the morning and evening. Or 2 150 mg tablets immediately at bedtime. If necessary, the dosage is increased to 4 150 mg tablets per day. Usually the course of treatment takes from 1 to 2 months. For preventive measures, you need to take 1 tablet of 150 mg at night. Smoking patients - 2 tablets of 150 mg.

Ranitidine when using NSAIDs

If the patient is taking non-steroidal anti-inflammatory drugs, then treatment with the drug is prescribed: 150 mg per day, or 300 mg at night for 1 to 2 months. For prophylaxis, 2 times a day - 150 mg.

Ranitidine for Zollnger-Ellison syndrome

Zollinger-Ellison syndrome, with a combination of a stomach ulcer and a benign tumor in the pancreas, the drug is taken 3 times a day, 150 mg or 2 times a day, 150 mg for 1-2 months. It all depends on the doctor's orders.

Ranitidine for children

The medicine is not prescribed to children under 12 years of age.

During pregnancy and lactation

It is not taken during pregnancy and lactation. The medicine is quickly absorbed, and its penetration affects not only the placenta, but also the fetus. Clinical researches were not carried out. Therefore, there is no data on its use during pregnancy. In addition, it has side effects.

Overdose

If you take too much of the drug, be sure to call an ambulance. Because your head may become dizzy, coordination of movements may be impaired, and you may faint

In case of an overdose of Ranitidine, you need to pay attention to the symptoms. If the patient: has a headache, begins to feel dizzy, feels sleepy, begins to get confused in his thoughts, or has a rash on his skin, a doctor is needed urgently. And before his arrival, it is necessary to call the patient vomiting reflex and then give Activated carbon. What to do if the patient does not take the dose of the drug on time? You can accept it as soon as you remember it. And if the time is approaching for the next dose, then you should not take the missed tablet. This will be a doubling of the dose of the medicine, which can have a bad effect on your well-being.

special instructions

According to the instructions, the drug Ranitidine in tablets can be taken as much as the doctor allows. The use of the drug must be discontinued gradually. In weakened patients treated for a long time, diarrhea may develop. During treatment, a decrease in concentration and psychomotor reactions occurs. It is advisable to quit smoking while taking the drug. Stop drinking alcohol. Smoking and alcohol irritate the gastric mucosa, and therefore the effectiveness of Ranitidine treatment is reduced.

Interaction with other drugs

If you take increased doses of aitacids and sucralfate, the drug will be poorly absorbed. Therefore, you need to take each Ranitidine every 2 hours with a break. If you take Ranitidine with procainamide at the same time, the latter will be poorly excreted by the kidneys. And the threat of increasing its concentration in plasma will remain. Ranitidine may interact with drugs such as glipizide, gaiburide, metoprolol, midazolam, nifedipine, phenytoin, theophylline, farfarin.

Domestic and foreign analogues

Ranitidine has the highest availability, that is, the amount medicinal substances, reaching the scene of action among their interchangeable counterparts. The list of the most popular ranitidine analogues is as follows:

Ranigast - treats heartburn, dyspeptic disorders, if there are no organic diseases in the digestive system.
Ranisan - used for indications: peptic ulcer of the stomach and duodenum, chronic gastritis, Zollinger-Ellison syndrome.
Rantak - used for heartburn.
Ulran - used for heartburn.

They have one or more substances with Ranitidine, which, when used, have the same effect.

Price in pharmacies

The price of Ranitidine in different pharmacies may vary significantly. This is due to the use of cheaper components and the pricing policy of the pharmacy chain.

Read the official information about the drug Ranitidine, the instructions for use of which include general information and treatment plan. The text is provided for informational purposes only and cannot serve as a substitute for medical advice.

Film-coated tablet contains 150/300 mg ranitidine hydrochloride . Excipients: silicon dioxide (colloid), MCC (type 12), copovidone, Mg stearate.

Film shell components (white Opadry AMB OY-B28920): soy lecithin, talc, xanthan gum, titanium dioxide, .

Injection(1 ml) contains 0.025 grams ranitidine hydrochloride .

Release form

Ranitidine is available in tablet form and in the form injections.

Film-coated tablets are packed in blisters of 10 pcs. A cardboard pack can contain 2, 3 or 10 blisters.
The solution for injection is available in ampoules of 2 ml.

pharmachologic effect

Ranitidine Akos– an antiulcer drug, the active substance of which belongs to the group of histamine H2 receptor antagonists. The principle of action is based on blocking H2 receptors in parietal cells located in the gastric mucosa, as well as on inhibiting the production of hydrochloric acid . Under the influence of the active substance, the volume of total secretion decreases, suppressing the activity pepsin V .

Thanks to antisecretory effect Ranitidine manages to create favorable conditions for healing ulcerative lesions in the digestive tract (stomach, duodenum). The active substance can have protective action by enhancing reparative processes, increasing the secretion of special mucous substances, and improving microcirculation.

Pharmacodynamics and pharmacokinetics

The active substance ranitidine is absorbed quite quickly from the lumen of the digestive tract. Food has no effect on the degree of absorption. Bioavailability reaches 50%. Already 2-3 hours after oral administration peak concentration is recorded. 15% bound to plasma proteins. Partial metabolism takes place in the hepatic system with the formation of ranitidine S-oxide and desmethylranitidine .

The drug is characterized by a “first pass” effect through the hepatic system. The condition of the liver affects the extent and rate of elimination. After oral administration, the half-life is 2.5 hours, and with a creatinine clearance of 20-30 ml/min, this figure increases to 8-9 hours.

A small amount is excreted from feces, the main part is excreted unchanged through the renal system. The active component does not pass the blood-brain barrier well, but penetrates the placenta well. Ranitidine is released during lactation.

Indications for use of Ranitidine

Ranitidine tablets - what do they help with? The main area of application of the drug is gastroenterology .

Ranitidine Akos- what does it help with? The drug is prescribed for the treatment various pathologies digestive system, and can also be used for prophylactic purposes.

Indications for use of Ranitidine Acri

symptomatic ulcerative lesions digestive tract;
(stomach, duodenum);
Zollinger-Ellison syndrome ;
prevention of aspiration of gastric juice during surgical interventions with the introduction of anesthesia;
prevention of the development of “stress” ulcers;
reflux esophagitis ;
erosive esophagitis ;
prevention of the development of ulcerative lesions of the gastrointestinal tract after surgical interventions;
relapse prevention from upper sections digestive tract.

Indications for use Ranitidine Sopharma similar.

Contraindications

For pathology excretory function renal system, stomach tablets are prescribed with caution.

Absolute contraindications:

lactation;
individual hypersensitivity;
carrying a pregnancy.

Ranitidine Acree not used in pediatric practice (age restrictions up to 14 years).

Side effects

Hematopoietic system:

leukopenia (with long-term therapy);

The cardiovascular system:

development (rarely, mainly with intravenous infusion).

Digestive tract:

stool disorders ( / );
hepatitis (rarely).

Side effects from the central nervous system:

vertigo , ;
fast fatiguability;
blurred visual perception;
(rarely);
confusion (extremely rare).

Endocrine system, metabolism:

level up ;
level up ;
gynecomastia ;
decline libido ;

Other reactions:

recurrent ;
arterial hypotension ;
bronchospasm ;
arthralgia ;
hair loss;
various rashes on the skin;
myalgia.

Ranitidine tablets, instructions for use (Method and dosage)

The treatment regimen is selected individually. The tablets are intended to be taken orally.

Daily dosage is 300-450 mg (can be increased to 600-900 mg if necessary), divided into 2-3 doses. To prevent exacerbation of diseases of the digestive tract, the drug is prescribed at bedtime at a dose of 150 mg. The duration of therapy is determined by the dynamics of the disease.

For pathology of the renal system, the medication is prescribed twice a day at a dose of 75 mg. Instructions for use of Ranitidine Akos are similar. Your doctor will tell you how long you can take the pills (on average, the course of treatment is 2-4 weeks).

Overdose

Main manifestations:

skin rashes;
confusion;
headache;
dizziness;
increased drowsiness.

First aid is to take enterosorbents ( , , and others), call an ambulance.

Interaction

There is a decrease in ranitidine absorption rates during treatment antacids . Elderly patients experience deterioration in attention and memory when simultaneous administration anticholinergic drugs . It is assumed that medications that block histamine H2 receptors are capable of suppressing the ulcerogenic effect of drugs from the group NSAIDs on the mucous wall of the stomach. There is a decrease in clearance when treated with Ranitidine. IN medical practice a case of bleeding and hypoprothrombinemia in a patient who took Warfarin .

Possible undesirable increase in ranitidine absorption rates during concomitant therapy . Cases reported hypoglycemia upon admission .

Ranitidine inhibits absorption And . Half-life and its AUC increase with ranitidine treatment. Absorption of the drug changes when taking high doses (more than 2 g).

There is a slowdown in excretion Procainamide through the renal system, which leads to an increase in the concentration of the active substance in the blood. Absorption Triazolam increases, which is associated with changes in the pH of gastric juice. The risk of toxicity increases with treatment , which is explained by a significant increase in its concentration in the blood. There is an increase in bioavailability with simultaneous therapy with Ranitidine.

IN medical literature there is a description of a case of development ventricular arrhythmia type bigeminy in a patient who was taking Ranitidine and Quinidine . During treatment the risk increases cardiotoxic damage . There is an increase in the level in the blood during parallel treatment with Ranitidine.

Terms of sale, recipe in Latin

Dispensed at pharmacies upon presentation of a prescription form from a doctor.

Rp: Tab. Ranitidini 0.15
D.t.d. N30
S. 1 tablet 30 minutes before meals 2 times a day.

Storage conditions

Ranitidine tablets are stored in their original packaging, subject to temperature regime from 15 to 30 degrees.

Best before date

special instructions

With pronounced pathologies of the renal system the medication is prescribed with caution. Before using the drug, it is necessary to exclude oncological diseases intestines , esophagus And stomach .

Long-term therapy of weakened patients who are in a state of stress can provoke the development bacterial disease stomach, as well as the subsequent spread of the inflammatory process.

If the medication is abruptly discontinued, the risk of relapse of peptic ulcer increases. Preventive therapy more effective when taking the drug for a course of 45 days in the fall and spring, compared to continuous use.

In patients suffering various disorders rhythm, rapid intravenous administration of the solution can provoke bradycardia . Persons with porphyria history of Ranitidine is prescribed with caution due to the risk of developing an acute attack.

Distortion of indicators is allowed laboratory research(enzymes hepatic system, creatinine, GGT). Time interval between doses antacids and Ranitidine should be at least 1-2 hours due to the risk of altered absorption active substance. Clinical studies confirming the safety of the drug in pediatric practice are limited.

Included in the preparations

Included in the list (Order of the Government of the Russian Federation No. 2782-r dated December 30, 2014):

VED

ONLS

Minimum pharmacy assortment

ATX:

A.02.B.A Histamine H2 receptor blockers

A.02.B.A.02 Ranitidine

Pharmacodynamics:

Histamine H2 receptor blocker. Suppresses basal and stimulated by histamine, gastrin and acetylcholine (to a lesser extent) secretion of hydrochloric acid. Helps increase the pH of gastric contents and reduces pepsin activity. Durationb effects of ranitidine with a single dose - 12 hours.

Pharmacokinetics: Interaction:

Aluminum phosphate. Against the background of aluminum phosphate, the absorption of ranitidine is reduced.

Acenocoumarol. When used in combination, it can either enhance or weaken the effect of acenocoumarol.

Acetylsalicylic acid + Chlorphenamine + . When used simultaneously with acetylsalicylic acid(as part of a combination + chlorphenamine +) increases its toxicity.

Bisacodyl. may cause too fast dissolution bisacodyl enteric coating and irritation of the gastric or duodenal mucosa; when administered in combination, the interval between doses should be at least 1 hour.

Warfarin. changes prothrombin time: it can be lengthened or shortened; When administered together, monitoring of hemocoagulation parameters is necessary.

Gliclazide + ., secreted in the tubules, competes for tubular transport systems and, with long-term combination therapy, can increase the maximum concentration of metformin (as part of the combination) by 60%.

Diazepam. Against the background of ranitidine, biotransformation slows down and the effect of diazepam may increase.

Dirithromycin. Against the background of ranitidine, the absorption of dirithromycin increases.

Ibandronic acid.(when administered intravenously) increases the bioavailability of ibandronic acid by 20%.

Itraconazole, . It is a weak acid and, against the background of ranitidine, which alkalizes the contents of the stomach, is absorbed with less speed and completeness; when prescribed together, a 2 hour (or more) interval between doses is required.

Metformin. slows down excretion, increases (by more than half) the maximum concentration (secreted by the renal tubules and competes for tubular transport systems), enhances the effect.

Metformin + . excreted by the kidneys by tubular secretion and theoretically can interact with metformin (as part of a combination), competing for common transport systems renal tubules. It is recommended to carefully monitor patients and, if necessary, adjust the dose of the combination and/or ranitidine if they are used simultaneously.

Metformin + [Sibutramine + Microcrystalline cellulose]., secreted in the renal tubules, competes with metformin (as part of the combination + [sibutramine + MCC]) for tubular transport systems and, when used in combination, can lead to an increase maximum concentration metformin.

Midodrine. may slow down (mutually) excretion by competing for the common transport system in the renal tubules.

Morphine. Ranitidine may alter the enterohepatic circulation; If coadministration is necessary, careful monitoring is necessary.

Naproxen. Against the background of ranitidine, which alkalizes the contents of the stomach, the absorption of naproxen is reduced; simultaneous use is not recommended.

Procainamide. Against the background of ranitidine, a decrease in excretion is possible (competition for excretory systems renal tubules) and an increase in the concentration of procainamide in the blood.

Propranolol. Against the background of ranitidine, the biotransformation of propranolol slows down.

Rilpivirine. Use with caution is suggested when administered concomitantly with ranitidine as this may result in a significant decrease in rilpivirine plasma levels due to increased gastric pH. should be taken at least 12 hours before or 4 hours after rilpivirine.

Sucralfate. Against the background of sucralfate, the absorption of ranitidine may be reduced; when administered in combination, the interval between doses should be at least 2 hours.

Theophylline. Against the background of ranitidine, the biotransformation of theophylline is inhibited.

Phenytoin. Against the background of ranitidine, the biotransformation of phenytoin slows down.

Cyclosporine. Ranitidine increases the risk of renal dysfunction.

Ciprofloxacin. Against the background of ranitidine, the absorption of ciprofloxacin is reduced (should be taken 2 hours before or 4 hours after ranitidine).

Special instructions:

Before starting treatment, the presence of malignant neoplasms in the stomach and duodenum (may mask symptoms of stomach cancer). The risk of cardiotoxic effects is increased in patients with heart disease, with rapid intravenous administration and use in high doses. It is not advisable to abruptly cancel due to the risk of exacerbation of the condition. At long-term treatment weakened patients under stress may experience bacterial damage to the stomach with subsequent spread of infection.

May increase glutamyl transpeptidase activity. When treating with ranitidine, a false-positive reaction is possible when testing for protein in the urine.

During treatment, patients should exercise caution when engaging in potentially dangerous species activities.

Instructions

Gastrointestinal diseases are an extremely common problem that affects people regardless of age and gender. For example, gastritis is often diagnosed among adolescents and sometimes in young children. Fortunately, modern medicine offers a lot inflammatory processes digestive tract. And one of them is the drug Ranitidine. The indications for use of this medicine are very wide. So what does it contain and how effective is such a product?

The drug "Ranitidine": composition and release form

The main active ingredient of the drug is ranitidine hypochloride. IN natural form is a white granular powder (sometimes with a yellowish tint) with a characteristic sulfur odor and bitter taste. This substance has antagonistic properties towards histamine H2 receptors.

The drug is available either in the form of tablets or as a solution for intramuscular or intravenous administration. There are also so-called “effervescent” tablets for preparing an aqueous solution.

The tablets are round, biconvex shape, covered with a light orange shell on top. As excipients used: sodium lauryl sulfate, colloidal corn starch, magnesium stearate, hypromellose, polyethylene glycol 6000, ethylcellulose and yellow dye.

Today, pharmacological companies offer tablets containing either 150 mg or 300 mg of the active substance. Injection solutions are available in glass ampoules with a volume of 2 ml.

Pharmacological properties of the drug "Ranitidine"

As already mentioned, the main active substance of the drug blocks histamine H2 receptors. This medicine mainly affects the functioning of the parietal cells of the gastric mucosa. Under its influence, the release of hydrochloric acid is inhibited, which leads to a decrease in the volume released and also a decrease in its acidity. By the way, this is why the drug Ranitidine for heartburn is very effective.

It is worth noting that histamine receptor blockers reduce the concentration of digestive enzymes (pepsin) in gastric juice. Inhibition of secretion creates optimal conditions for healing ulcers on the mucous membrane, which naturally speeds up the healing process.

Besides, active ingredients the drug affects the gastroduodenal zone, increasing the activity of local defense mechanisms, increasing the secretion of protective mucous secretion. The drug also accelerates regeneration processes.

At the same time, the medicine does not have any effect dangerous influence on the body. In particular, it does not affect the concentration of calcium ions in the blood and does not interfere with the functioning of endocrine system, does not affect the processes of spermatogenesis. The research results also showed that the drug does not have a carcinogenic effect and does not cause mutations. On the other hand, the active substance penetrates the placental barrier and into breast milk.

After administration, the medicine is quickly absorbed by the wall of the digestive tract. Its maximum concentration in the blood is observed after 2-3 hours. In most cases, the effect lasts about 12 hours. During metabolism, it is partially converted in the liver. It is completely excreted from the body by the kidneys within 24 hours after administration.

The drug "Ranitidine": indications for use

This medicine is widely used as However, there are a lot of disorders for which doctors prescribe the drug Ranitidine. Indications for use are as follows:

It is only worth noting that acute diseases- are not the only ailments that require treatment with the drug Ranitidine. Indications for use include prevention of exacerbations chronic gastritis and peptic ulcer.

How to take the medicine correctly?

Of course, before you start using this medicine consultation with a doctor is required. All doses are determined individually, as they depend on the age and condition of the patient, the form of the disease, and the purpose of administration (treatment or prevention):

Adult patients are advised to take tablets with a dose of the active substance of 150 mg twice a day. In some cases, doctors recommend taking two tablets at once before bed.
To prevent bleeding, the patient is administered intramuscularly (or intravenously) 0.05 - 0.1 g at intervals of 6-8 hours (if necessary, the dose can be increased to 0.9 g).
Teenagers typically take 150 mg twice daily.
During treatment benign tumors The recommended dose is 150 mg of the active substance three times a day.

Typically, the duration of treatment is four to eight weeks. If we are talking about prevention, then some patients are recommended to take the drug for several months, and sometimes a whole year, but under the constant supervision of a doctor and with regular endoscopic examinations.

Contraindications to the use of the drug "Ranitidine"

Like any other medicine, this drug cannot be used by every patient. In particular, it is prohibited to be used to treat women during pregnancy and breastfeeding, since active substances easily penetrate into milk and pass the placental barrier. Contraindication is increased sensitivity to any constituent substance of the drug. Ranitidine is not used in the treatment of children under 14 years of age.

Besides, this remedy used with caution to treat patients diagnosed with hepatic or renal failure, as well as acute porphyria and cirrhosis of the liver.

What side effects are possible during treatment?

Unfortunately, the active components of the drug affect almost all organ systems. Therefore, in some patients, taking the drug may be associated with some adverse reactions:

Headaches, drowsiness, increased anxiety, fatigue, dizziness, and blurred vision are often observed. In more serious cases, the medicine may cause confusion, development depressive states, the occurrence of hallucinations.
Possible malfunctions of cardio-vascular system, in particular, a decrease blood pressure, aplastic or hemolytic anemia, arrhythmia, tachycardia, thrombocytopenia, less often - bone marrow hypoplasia.
Allergic reactions are often accompanied by the appearance of skin rash and itching, fever, swelling, and erythrema. It is extremely rare that taking the drug leads to anaphylactic shock.
Nausea and vomiting and abdominal pain may occur. It is extremely rare that treatment leads to the development of pancreatitis and some forms of hepatitis.

If any side effects occur, you should stop taking the medication and describe the symptoms to your doctor.

Additional information about the medicine

Before starting this medication, a thorough examination is usually carried out, as it is extremely important to ensure that there are no malignant tumors in the stomach and small intestine. The fact is that the drug can mask the main symptoms of cancer.

Long-term treatment of patients with weakened immune system and depletion of the body can lead to bacterial damage to the stomach tissue.

Ranitidine should be stopped gradually, reducing the dose day by day. Abrupt withdrawal of the medication can provoke an exacerbation of peptic ulcer disease.

How does the drug Ranitidine interact with other drugs?

Quite often, therapy includes the simultaneous use of this medication and antacid drugs that reduce acidity in the stomach. In such cases, the break between taking these medications should be at least 1-2 hours.

The drug "Ranitidine" complicates the absorption of ketoconazole, and also inhibits the metabolic processes in the liver of diazepam, metronidazole, lidocaine and some other drugs. By the way, smoking significantly reduces the effect of taking this drug.