Ceftriaxone during breastfeeding Komarovsky. Ceftriaxone (Rocephin) during pregnancy, breastfeeding and childhood: description of the drug and instructions for use

Ceftriaxone is a third generation antibiotic used in the treatment of:

The drug is also prescribed for the prevention of infections in the postoperative period.

Important! When treating with Ceftriaxone, you need to take prebiotics to normalize the microflora in the intestines. This way you can avoid some unpleasant consequences, because the antibiotic kills not only “bad” bacteria, but also necessary for a person to digest food.

How does the drug work?

The main active ingredient fights murein, which is produced by a bacterial cell. However, some bacteria are resistant to the antibiotic, so For successful treatment, a sensitivity test should be performed.

Most often, Ceftriaxone is prescribed only for inpatient use. Long-term treatment requires monitoring the condition of the kidneys, liver and blood.

Contraindications and side effects

When taking an antibiotic, the following are possible: side effects:

Note! Ceftriaxone should not be taken by a nursing mother if the baby has hyperbilirubinemia, as the drug binds to albumin and displaces bilirubin, which is necessary to fight the disease.

If side effects occur, you should consult your doctor to adjust the dose or discontinue the drug altogether, since bad feeling mother's health will definitely affect the child's health.

Contraindications include hypersensitivity to the drug, renal or liver failure, colitis, vitamin K deficiency or problems with its synthesis.

How does it affect lactation and the baby during breastfeeding?

The instructions for use of the drug state that breastfeeding should be stopped. The half-life of the antibiotic in mother's milk is approximately 17 hours, so when taken this drug lactation should be suspended, which can be established after stopping treatment.

Some experts are confident that the medicine can be combined with breastfeeding, but precautions should be taken. In any case, the doctor will give advice to the woman regarding the use of antibiotics during this crucial period.

Maximum concentration in the blood (when administered intramuscularly) is achieved after 2.5 hours. If the drug is administered intravenously, the medicine acts faster - within an hour. This means that you cannot feed the baby during the specified time. The percentage of antibiotic in breast milk is 4.2%.

If the doctor has authorized the use of the drug for breastfeeding, That You should carefully monitor the child’s condition, as the following may occur:

allergy;
upset stomach, stool.

If these symptoms are detected, the drug should be discontinued.

Dosage

The dosage for adults does not differ from that permissible for breastfeeding: 1-2 g once a day or 0.5-1 g every 12 hours. It should be remembered that You cannot self-medicate, discontinue the drug yourself, or increase the duration of treatment.

For a nursing woman, the first regimen for taking Ceftriaxone is suitable, since with a single dose you can wait 17 hours. As mentioned above, this is exactly the time it takes for the antibiotic to be eliminated from the body.

The drug is produced in the form of a powder, which, when prepared, is administered intravenously or intramuscularly. For administration, only freshly prepared solution should be used; it cannot be stored.

Sometimes, with intravenous administration, phlebitis occurs, pain along the vein, and with intramuscular injection– pain at the injection site.

Conclusion

So, some diseases require emergency treatment. The use of antibiotics is contraindicated for women who are lactating, but there are exceptions. If a nursing mother is prescribed Ceftriaxone, she must follow the dosage, monitor the baby’s condition after feeding and her own well-being.

Not a single nursing mother is immune from pathogenic bacteria entering her body. If a woman becomes infected with a bacterial infection during lactation, there is a need for treatment with antibiotics to avoid the development of complications. However, many women consider taking such drugs incompatible with breastfeeding. But in some cases, antibiotic therapy is necessary during lactation, so women need to know how to protect themselves and their baby from negative consequences.

Characteristics and properties of antibiotics

The fundamental difference between antibiotics and other drugs is that their action is aimed directly at bacteria, disrupting their viability and preventing reproduction.

Does not exist universal remedy, affecting all bacteria. Some drugs affect several dozen pathogens, others - two or three types.

Bacteria can be divided into two groups:

transmitted by airborne droplets and damaging Airways. Most often these are streptococci, staphylococci, meningococcus, etc. Penicillin and Erythromycin can affect such bacteria;
getting into the mouth through dirty hands, water and food. Most often these are E. coli, dysentery coli, salmonella, etc. Polymyxin will be effective here.

But, for example, Ceftriaxone and Ampicillin will be effective against bacteria of both groups.

The main task of an antibiotic is to reach the source of infection in a certain concentration. Each drug has its own unique sphere of activity. It is important that the remedy is destructive against the microorganism that caused the disease. Therefore, the choice of antibiotic is only a medical privilege. Self-prescription is unacceptable, especially during lactation.

Drugs prescribed during breastfeeding

There are several common antibiotics used during lactation. Sometimes your doctor may prescribe medication that will require you to temporarily stop breastfeeding. You shouldn't be afraid of this.

Most doctors agree that antibacterial drugs local application Some pathogens develop resistance (resistance). In the future, this may cause unsuccessful treatment with this antibiotic in any form.

Flemoxin Solutab is an antimicrobial agent belonging to the group of penicillins. Broad-spectrum antibiotic. The active ingredient of Flemoxin is amoxicillin.
The active ingredient of the drug Flemoxin Solutab is amoxicillin

The drug is indicated for infectious and inflammatory diseases:

respiratory organs;
reproductive and urinary systems;
organs of the gastrointestinal tract;
skin.

The only absolute contraindication is individual intolerance to the components of the drug. The instructions indicate that the medicine should be used with caution during lactation.

The drug may cause side effects such as:

nausea, vomiting, diarrhea, dullness of taste;
allergic reaction in the form of a rash.

Amoxicillin's interactions with certain medications may reduce its effect or lead to other negative reactions. Therefore, you should definitely tell your doctor about any medications you are already taking, including oral contraceptives.

The course of treatment is determined by the doctor and ranges from 5 to 10 days. The frequency of administration and dosage are also set by a specialist depending on the clinical picture.

Time of elimination from the body is 8 hours.

It should be noted that the cost of the drug Flemoxin Solutab is approximately 300 rubles. While its absolute analogue Amoxicillin costs up to 100 rubles.

Ceftriaxone is a broad-spectrum antibiotic belonging to the group of cephalosporins, which are most often prescribed by doctors in our country for the treatment of bacterial infections.
Ceftriaxone is not compatible with breastfeeding

The drug is available in powder form for the preparation of a solution, subsequently administered intramuscularly or intravenously.

Ceftriaxone is prescribed for bacterial infections:

organs abdominal cavity and gastrointestinal tract, including: typhoid fever, salmonellosis;
respiratory tract;
skeletal system, joints, skin;
genitourinary system;
central nervous system: meningitis, etc.

Contraindications for the use of the drug are individual intolerance, as well as the lactation period. The instructions indicate that while taking the medicine you should stop breastfeeding.

Use with caution when chronic diseases liver and kidneys, gastrointestinal tract organs.

The elimination period for Ceftriaxone is 48 hours. Usually prescribed for a course of 7–10 days.

Taking the drug may be accompanied by the following adverse reactions:

dizziness, headache;
cardiopalmus;
bleeding from the nose;
abdominal pain, nausea, vomiting;
rash, court;
painful sensations at the injection site.

Taking Ceftriaxone is incompatible with other antimicrobials and alcohol-containing products.

Despite the effectiveness of the medicine and its wide range of applications, its price cannot but surprise - less than 50 rubles.

Cefotaxime is an antibiotic, like Ceftriaxone, classified as a cephalosporin. The release form of the drug is powder for the preparation of injections for intravenous or intramuscular administration.

When taking Cefotaxime, lactation must be stopped.

The method of administration and dose are selected by the doctor individually for each patient.

Cefotaxime is indicated for diseases such as:

infections of the lungs and upper respiratory tract;
meningitis;
rhinitis, pharyngitis, sinusitis, laryngitis;
infections in bones and joints;
gonorrhea.

The contraindications section in the instructions for the drug includes individual hypersensitivity of the body to the components of the drug, pregnancy and lactation.

The use of the drug may be accompanied by side effects such as allergies, headaches, and gastrointestinal disorders.

Incompatible with some other medications, such as antibiotics, in the same syringe or dropper. At simultaneous administration with drugs that block tubular secretion, the period of drug elimination increases. When used together with nonsteroidal anti-inflammatory drugs, the risk of bleeding increases.

The price of this antibiotic is less than 100 rubles.

Vilprafen is an antibiotic from the group of macrolides that has an antibacterial (killing bacteria or suppressing their activity) and bactericidal (causing the death of bacteria) effect.
Vilprafen is an antibiotic of the macrolide group, which has a wide spectrum of action and is used in the treatment of many infectious diseases.

Vilprafen is prescribed for such infectious diseases, How:

angina;
pharyngitis;
inflammatory processes in the ear;
sinusitis, laryngitis, tonsillitis;
diphtheria, scarlet fever;
bronchitis, pneumonia, whooping cough;
skin infections;
prostatitis, syphilis, gonorrhea;
pyelonephritis.

Contraindications to the use of this drug are sensitivity to macrolide antibiotics and disturbances in liver function.

Side effects include:

nausea, vomiting, diarrhea, loss of appetite;
skin itching, urticaria.

Therapy with Vilprafen should not be combined with taking certain antibiotics, antihistamines and other drugs. Therefore, when prescribing this medicine, you should mandatory Tell your doctor about other medications you are taking.

The duration of therapy and dosage are determined by the doctor. As a rule, the course of taking Vilprafen lasts at least 10 days.

It is eliminated from the body after 12 hours.

The drug is not recommended for use during lactation, since the effect has not been proven active substance(josamycin) on the composition and quality of breast milk. However, in practice, this remedy is prescribed to nursing mothers quite often.

Vilprafen can only be prescribed by a doctor on an individual basis. The cost of this medicine is about 500 rubles.

Another macrolide antibiotic is Erythromycin. Its use during the lactation period is considered safer.
Erythromycin is used with caution during lactation

Prescribed for the same indications as Vilprafen, for a course of 7–10 days.

Among adverse reactions noted:

nausea, vomiting, diarrhea;
negative effect on the liver;
skin reactions (rash, itching).

Contraindications include: hypersensitivity to the components of the drug and liver failure.

The price of Erythromycin varies from 10 to 25 rubles.

Factors influencing the timing of drug removal from the body

The timing of antibiotic elimination is influenced by:

a set of components that make up a medicinal product. This is due chemical structure substances;
route of entry into the body. For example, injections are eliminated faster than tablets;
the age of the patient (the older the person, the slower this process);
condition of internal organs (for example, kidney and liver diseases slow down the removal of drugs from the body);
time of taking the antibiotic associated with eating (before, after or during meals). Often patients simply do not pay attention to these recommendations in the instructions, but if they are not followed, the process of removing the medication from the body can be slowed down;
drinking large amounts of liquid, which speeds up the process.

Recommendations for taking antibiotics while breastfeeding

do not self-medicate;
be sure to notify your doctor that your child is breastfed;
if you accept others medicines- be sure to mention this at your doctor’s appointment;
Be careful when taking medications, monitor your body’s reaction and the baby’s condition;
do not adjust the dosage, frequency of administration and duration of treatment suggested by the doctor;
Consult a doctor to change treatment tactics if side effects occur when taking an antibiotic, or if the effect of treatment is not observed after 48 hours.

Even antibiotics approved by a doctor can cause a negative reaction in the baby, for example, problems with stool. Therefore, if the schedule for taking the medicine allows, then it is more advisable to take it immediately before feeding. While the baby is eating, the medications will not have time to penetrate into the milk, but it will pass before the next feeding. maximum amount time.

If there is a need to stop breastfeeding for a while, take it for granted. After finishing treatment, resume lactation.

Video: Dr. E.O. Komarovsky about taking antibiotics during lactation

The drug should not be used by people with high sensitivity, with renal or liver failure, colitis. Antibiotics are not recommended for pregnant women and during lactation.

Ceftriaxone during lactation

The half-life of the antibiotic in breast milk lasts about 17 hours, so it is best to stop using this medication breastfeeding. However, after the end of the dose, feeding is returned. How to improve breast milk production, read the article on restoring lactation.

However, no negative effects were found in newborns who were breastfed and used this drug. Many experts are confident that Ceftriaxone can be combined with breastfeeding, if you take precautions and replace only some breastfeeding with artificial formula.

The maximum concentration in the blood with intramuscular administration is 2.5 hours, and with intravenous administration - an hour after injection. This means that during this time you cannot feed the baby after administering the drug. The best option will be fed before taking the antibiotic.

The dose of the drug that passes into breast milk is 4.2% of the total composition of breast milk. This small proportion will not adversely affect the baby if the dosage is followed.

Safe dose when breastfeeding, it is 1-2 grams twice a day.

If the doctor has allowed you to combine breastfeeding and taking an antibiotic, then carefully monitor the baby’s well-being. The baby may have colic and stomach upsets, an allergic reaction and even poisoning. If such consequences occur, stop taking it!

It is important to monitor your baby's stool. Diarrhea in a breastfeeding baby can be caused by this drug. Read about the norms of stool in a newborn in the article “What should a baby’s stool be like?”

Dosage

The usual dosage for adults does not exceed permissible norm when breastfeeding. The dose is 1-2 grams once a day or 0.5 - 1 gram every 12 hours.

When breastfeeding, the first option is suitable. Since taking the drug once a day will allow you to skip more than 17 hours between administrations. As stated earlier, this is how long it will take for Ceftriaxone to break down. For administration, use only freshly prepared solution.

vskormi.ru

Ceftriaxone during breastfeeding

When breastfeeding, any medication should be taken with caution. increased attention. Most often, during this period it is not recommended to use antibiotics to treat various diseases. The appropriateness of their use is assessed by the attending physician.

Ceftriaxone is used during breastfeeding to eliminate bacterial infections that can affect the upper respiratory tract. For ease of use, the drug is available in powder form, which is used to prepare a solution. Subsequently, it should be administered through the injection method.

Effect of the drug

Murein is used as the main active component of Ceftriaxone. It is produced by a bacterial cell. After Ceftriaxone it is possible to kill a large number of bacteria harmful to the mother's body. However, some harmful cells have already developed immunity against it. In this case, the therapy will not achieve the long-awaited effect. Nursing mothers must undergo a special sensitivity test before using the drug.

Ceftriaxone is an antibiotic that is used to kill harmful bacterial cells and microorganisms. It is important to use the remedy only if this type of infection does not have developed immunity.

After the injection, you can feed the baby only seven hours later

It is advisable to use the drug in following cases:

Severe inflammatory process in gastrointestinal tract, which has already turned into peritonitis.
Pneumonia or abscess in the lungs was previously diagnosed.
Infectious lesion soft fabric, individual bones or joints.
Meningitis.
Inflammatory process in the renal pelvis (pyelonephritis).
Gonorrhea.
There is an infection in the body individual organs microbes (sepsis).
Burns and wounds that are infectious.

Additionally, it should be noted that the drug can also be used for prophylactic purposes during feeding. A woman should understand that its use is only advisable if prescribed by a doctor. Self-medication in this matter is not acceptable.

The drug can only be used in a hospital setting. During the course, you should additionally monitor the condition of the liver, kidneys and blood. If the drug is administered to elderly people, then the course should be supplemented sufficient quantity vitamin K.

Contraindications for use and side effects

The drug and breastfeeding are compatible. However, there is a risk of negative manifestations.

It lies in the following symptoms:

Allergic reaction, which appears in the form severe rash, hives, itching or swelling.
Strong pain in the head and dizziness.
Nausea progressing to vomiting.
Severe pain in the abdominal area accompanying diarrhea.
Inflammatory process in oral cavity(stomatitis).
Change in taste sensations.
Periodically occurring shortness of breath or tachycardia.
Horse racing blood pressure.
Anemia and symptoms that are characteristic of this disease.

From reception medicinal product people with hypersensitivity to individual components. It is contraindicated renal failure, colitis and other diseases. Antibiotics should not be used during pregnancy and breastfeeding.

Parents and doctors should closely monitor the baby's condition

Features of using the drug during breastfeeding

Antibiotics completely dissolve in the human body within seventeen hours. It is strictly not recommended to feed your baby breast milk during this period. As soon as this period is over, lactation can be fully restored. If necessary, a woman can contact a specialist in this matter, who will help organize the process in a short time.

It should be noted that a large number of tests have been carried out in this area. As a result, no negative effect and impact on the baby. This is why, according to many experts, it is permissible to combine Ceftriaxone and breastfeeding. Breast milk can be replaced with a mixture only if a woman wants to play it safe.

It is important to know that the maximum amount of the substance in the blood occurs 2.5 hours after the injection. It is during this period that doctors recommend refraining from breastfeeding. After this, the amount of antibiotic begins to decrease sharply.

When the drug penetrates into milk, it makes up no more than 4.2% of its total number. This ratio cannot negatively affect the child and the formation of his body. Mommy is advised to strictly adhere to the dosage determined by the doctor.

The dose and frequency of injections is determined by the doctor

It has been scientifically determined that the safe amount of the drug is from one to two grams per day.

If a decision has been made to combine lactation and antibiotic treatment, the woman should be closely monitored. general condition and the baby’s well-being. Side effects may include colic, allergies and diathesis. Unfortunately, cases of severe food poisoning. If such a reaction occurs, it is recommended to immediately stop taking it.

Parents should first of all pay attention to the baby's stool. Diarrhea is one of the common consequences that is recorded while taking Ceftriaxone.

Dosage and purpose of the drug

Most often, doctors prescribe a volume that can be administered during breastfeeding. During the day it should not exceed two grams. For getting maximum effect It is recommended to administer 0.5-1 grams every twelve hours.

Experts recommend using the first option. Otherwise, it will not be permissible to feed the baby for seventeen hours in a row during the day. It is during this time that the antibiotics will be able to completely dissolve. Additionally, it should be noted that it is allowed to give injections only with the solution that was just prepared.

mladeni.ru

Ceftriaxone for nursing mothers

(8.50 out of 10) Loading...

CEFTRIAXONE is an antibiotic belonging to the third generation cephalosporins. It has a wide spectrum of action and is often used in the treatment of newborns. Available in tablets and ampoules (for injections).

Ceftriaxone is compatible with breastfeeding, although symptoms should be monitored loose stool The child has.

How long is ceftriaxone excreted from breast milk?

The half-life of ceftriaxone in breast milk is 12-17 hours (longer than in maternal plasma), however, no adverse effects have been found in children.
The maximum concentration in the blood is after 60 minutes.
Only 4.2% of the maternal dose passes into breast milk.
A safe dose of ceftriaxone for a nursing mother is 1000-2000 mg 2 times a day.

Like any antibiotic, ceftriaxone has side effects and precautions. Do not use antibiotics in treatment without the consent of your doctor! However, if the doctor insists on ending lactation due to treatment, try looking for another specialist. Read also: how to understand that your doctor is against breastfeeding.

See also: other medications for hepatitis B.

Sources: 1. Hale T. Medications and Mother's Milk, 2010

Synonyms: can a nursing mother take ceftriaxone?

The doctor prescribed the antibiotic Ceftriaxone, I am breastfeeding

Compatibility of ceftriaxone and lactation

Ceftriaxone - instructions for hepatitis B

Group of drugs: antibiotics.

Dear women! Do not take antibiotics on your own if you have chest pain or another problem. Today, consultations with a mammologist are available not only in your city, but also online (for example, see the doctor search portal DocDoc.ru). Uncontrolled treatment with antibiotics can lead to new troubles...

(8.50 out of 10)

am-am.info

Is ceftriaxone suitable for women who are breastfeeding?

Ceftriaxone is used to treat a large number of serious infections that are caused by organisms that are resistant to other antibiotics. Pneumonia of varying severity and degree is often treated with ceftriaxone at home. This drug is also effective in the treatment of bacterial meningitis, which is caused by pneumococci, meningococci, Haemophilus influenzae and susceptible enteric gram-negative bacilli, but not listeria.

Other uses of ceftriaxone include:

acute bacterial otitis media;
joint and bone infections;
intra-abdominal infections;
infections urinary tract;
inflammatory diseases pelvic organs;
surgical prophylaxis.

Regarding pregnancy, ceftriaxone was assigned category B. In animal studies, no connection was found between taking the drug and birth defects, which was also confirmed by preliminary studies in humans.

Video about the effects of antibiotics During breastfeeding, ceftriaxone enters mother's milk in minimal concentrations, while the manufacturer himself does not recommend that nursing mothers continue breastfeeding while taking the drug or do so with extreme caution.

The drug has a lot of side effects, but there are also a lot of positive properties. Thus, ceftriaxone precipitates in the bile, forms sediment and stones in gallbladder, to which children are most susceptible. In addition, the medicine may cause allergic reactions similar to those caused by penicillin. This should be taken into account when prescribing the drug.

Other common side effects include irritation at the injection site, rash, and diarrhea. Specific side effects include hypoprothrombinemia and bleeding.

That is, before you start taking a medication, you should weigh the risks and benefits, and in no case prescribe ceftriaxone yourself, especially if you are breastfeeding. Any prescription should be made only by a doctor, after a detailed study of the patient’s medical history and related nuances, for example, allergic reactions.

If the patient is allergic to the drug or its components, using ceftriaxone is strictly prohibited! This is the case when treatment will only harm the patient and become a reason to fight even more diseases or even die.

Also, ceftriaxone is not recommended for newborns with hyperbilirubinemia, especially premature ones. This is due to the opinion that the drug can displace bilirubin, which is necessary for the child’s body, from its binding sites with albumin.

Video about the dangers of antibiotics When using intravenous calcium-containing solutions/products, combination with ceftriaxone is also contraindicated, even if these drugs are administered through different infusion lines. Ceftriaxone calcium can settle in the neonatal kidneys and lungs, causing death in the newborn.

The work of the drug is aimed at suppressing bacterial cell wall synthesis by attaching to penicillin-binding proteins (PBPs). Thus, the transpeptidation step in peptidoglycan synthesis, necessary for bacterial cell walls, is suppressed.

Video about taking medications while breastfeeding

Ceftriaxone, like other cephalosporins, is a bactericidal drug. The question of killing bacteria depends only on time. In this case, the removal time of the drug itself from the human body is seven to eight hours. But before leaving the body, it penetrates into all its tissues and fluids, reaching even the level cerebrospinal fluid, which helps inhibit many pathogens.

The medical drug is introduced into the body only intravenously or intramuscularly by injection. Oral administration is unacceptable! Most infections are treated with a dose of 15-50 mg/kg/day, administered daily every 24 hours.

promum.ru

Ceftriaxone (Rocephin) during pregnancy, breastfeeding and childhood: description of the drug and instructions for use

Bacterial infections in pregnant women and babies can cause serious problems. Delay in treatment is very dangerous. Therefore, ceftriaxone is one of the most commonly used antibiotics.

What is ceftriaxone

It is a semisynthetic cephalosporin antibiotic for parenteral administration. By disrupting the synthesis of the outer shell of the microbial cell, it causes the disintegration and death of pathogenic microorganisms. The drug is active against most currently known strains of Enterobacteriaceae, Escherichia coli, Pseudomonas aeruginosa and Haemophilus influenzae, Klebsiella, Moraxella, meningococci, Proteus, the causative agent of gonorrhea, Staphylococcus aureus and Staphylococcus epidermidis, Streptococci, Bacteroides, Clostridia, Peptostreptococcus. The special value of Rocephin is its ability to resist substances secreted by microbes (beta-lactamases) that destroy other antibacterial agents. That is, ceftriaxone is a reserve drug used against pathogens resistant to penicillin, imipenem and other beta-lactam antibiotics.

Already 2 hours after injection, Rocephin is completely distributed in the tissues of the body. Up to 67% of the administered dose is excreted by the kidneys in active form, the rest - with bile into the intestines and then - with feces, but in a microbiologically inactive form. At the same time, the long half-life - about 7 hours - gives the patient the opportunity to make only one, maximum two injections per day.

The drug easily penetrates the placenta, into the fluid of the middle ear, into inflamed meninges, reaching a therapeutic concentration.

Indications for use of ceftriaxone

An antibiotic is prescribed for wide range microbial infections:

acute otitis media;
defeats subcutaneous tissue and skin;
bacterial sepsis, intrauterine infections;
respiratory diseases and pneumonia;
uncomplicated acute gonorrhea and pelvic inflammation of gonorrheal etiology;
urinary tract infections, epididymitis, prostatitis;
after sexual violence - to prevent infection with sexually transmitted infections;
inflammation of the kidney tissue (pyelonephritis);
meningitis, neurosyphilis;
infections of joints and bones, including osteomyelitis;
inflammation of the peritoneum (peritonitis) and pelvic organs;
nosocomial infections;
surgical diseases abdominal organs, including after surgery, if there is a high risk of bacterial complications.

The low resistance of pathogenic bacteria to the drug makes it possible to prescribe it immediately, even before obtaining the results of culture tests for sensitivity to antibiotics.

Ceftriaxone: release forms, storage and use rules

The drug is used in the form of ceftriaxone disodium salt: a white crystalline powder for injection, packaged in sterile glass bottles of 0.5 or 1 gram. In addition to the chemical name, the trade name is also used - Rocephin.

The antibiotic can be stored at room temperature in a place protected from light and heat sources. Before use, it is important to make sure that the powder has not turned yellow or “caked” due to the seal of the bottle being broken and moisture penetrating inside.

The drug is administered intramuscularly or intravenously after dilution. The finished solution has yellowish color with different shade saturation (up to amber) depending on the type of solvent and the resulting concentration of the antibiotic.

Important: despite the ease of dissolution of the antibiotic, it must be diluted with water for injection or saline solution. Combination with calcium (in Ringer's or Hartmann's solution) causes the formation of a dense sediment, and anesthetics (novocaine, lidocaine) significantly increase the risk of developing an allergic reaction.

The average therapeutic dose for an adult, including pregnant women, is 1-2 (maximum 4) grams per day. The specific dosage, as well as the duration of the course of therapy (7-30 days), is determined by the treating doctor. It depends on the type of infection detected and the severity of the disease. For children, the drug is prescribed in a dose of 25 to 100 mg/kg/day, more often 50 mg/kg, but not more than 1 gram per day. Adolescents weighing more than 45 kg are allowed to administer up to 2 grams per day.

Contraindications for use and side effects

Ceftriaxone is not prescribed to patients with allergies to antibiotics of the cephalosporin and penicillin classes due to high risk severe anaphylactic reactions up to shock. Due to its antagonistic effect, it is incompatible with Levomycetin (chloramphenicol).

Rocephin (like most other antibiotics) disrupts the vital activity of beneficial microflora in the intestines. This may manifest as antibiotic-associated diarrhea varying degrees severity: from mild intestinal upset to fatal colitis. The longer the course of treatment, the more colonies of resistant pathogenic microbes appear. They release toxins into the intestines that damage not only the gastrointestinal tract, but also internal organs. If a connection between diarrhea and the administration of the drug is confirmed, its use should be discontinued. For recurrent colitis (inflammation of the intestines), ceftriaxone should be taken very carefully.

Cases of immune-mediated hemolytic anemia, including fatalities, during treatment with ceftriaxone (and other cephalosporins). The mechanism of its occurrence is not fully understood. Therefore, it is important to control red blood during therapy and immediately discontinue the antibiotic if rapid decline hemoglobin.

Particular care should be taken in selecting the dose and duration of use of the drug in patients with severe liver or kidney failure, including gestosis in a pregnant woman.

Rarely, an increase in prothrombin time is possible, causing increased bleeding. This requires monitoring of the coagulogram and prophylactic administration of vitamin K.

With existing cholecystitis, cholelithiasis or chronic pancreatitis Ceftriaxone-calcium salts may appear in the gallbladder. They are visible on ultrasound and can cause exacerbation with pain syndrome. The salts completely dissolve after stopping the antibiotic and conservative therapy dyskinesia.

During treatment, false positive reactions to sugar in urine and blood tests are possible. Therefore, it is important to notify your doctor about your diabetes mellitus or impaired carbohydrate tolerance, so that the doctor correctly interprets the results obtained laboratory research.

Rocephin at joint use enhances the undesirable side effects of aminoglycoside antibiotics (for example, gentamicin), anticoagulants (Warfarin), cyclosporine, heparin.

Intramuscular injection Ceftriaxone is painful and leaves noticeable redness on the skin. With rapid intravenous administration, especially with a low dilution of the antibiotic, there is a high probability of osmotic damage to the vein with the development of its inflammation (phlebitis).

Features of using ceftriaxone during pregnancy

The antibiotic is approved for use at any stage of gestation. Animal studies have found no evidence of toxic effects on the fetus or the ability to cause malformations. Even with a 20-fold dose, it does not reduce the ability to conceive and bear fruit.

During treatment, the doctor will monitor the condition of the expectant mother’s biliary tract, liver, kidneys and blood coagulation system for early detection side effects of the drug.

Disruption of the microbial balance against the background of a physiological decrease in immunity during the administration of ceftriaxone often leads to an exacerbation of thrush.

Prescription of ceftriaxone during lactation

The drug is considered compatible with breastfeeding. On the third day from the start of treatment after intramuscular or intravenous administration for a woman, 1 gram of ceftriaxone, the peak concentration of the drug in breast milk is observed after 4 hours. It reaches only 0.7 or 0.5 mg per liter, respectively. This is a tiny dose: approximately 0.5% of the maternal dose. In most cases, it does not affect the baby's body in any way.

Very rarely, there are reports of a child developing thrush or symptoms similar to antibiotic-associated diarrhea (relaxed watery stools, intestinal colic). But there is strong evidence linking a woman’s use of the drug with intestinal disorder the baby is not provided. However, the manufacturer recommends that nursing mothers not self-medicate and be sure to coordinate the prescription of the medication (like any other) with a doctor.

Features of the use of ceftriaxone in childhood

For newborns (up to 28 days of life), especially premature ones, the drug is prescribed with extreme caution. The reason is its ability to displace bilirubin, which is toxic to the baby’s brain, from its inactivating connection with blood albumin. As a result, not only when hemolytic disease, but also with physiological jaundice, the risk of developing bilirubin encephalopathy in the baby greatly increases.

Co-administration of ceftriaxone with any calcium-containing drugs is contraindicated, including for parenteral nutrition, in very premature or operated infants. This is due to the formation of insoluble calcium salts, which can cause the death of a child due to multiple organ failure.

After vaccination against tuberculosis, ceftriaxone may interfere with the formation of an immune response to BCG vaccine and some other live vaccines. Therefore, its use during the first 1.5-2 months after vaccination is undesirable.

Combining medications and breastfeeding is an issue that worries nursing mothers. International medical research shows that many medications, especially antibiotics, cannot be combined with breastfeeding.

Ceftriaxone is a third-generation antibiotic with a broad spectrum of action that is used to treat bacterial infections and respiratory diseases. The drug is a powder for preparing a solution, which is administered intramuscularly or intravenously.

Effect of the drug

Ceftriaxone is designed to block murein, which is produced by the bacterial cell. Thanks to this, bacterial microorganisms die. However, many bacteria are resistant to the antibiotic. To ensure that therapy is not unsuccessful, it is necessary to conduct a certain sensitivity test.

Ceftriaxone helps with the following diseases:

Inflammation of the gastrointestinal tract and peritonitis;
Pneumonia and lung abscess;
Infections of the skin and soft tissues, bones and joints;
Meningitis;
Pyelonephritis (disease of the renal pelvis);
Gonorrhea;
Sepsis (general infection of the body with microbes);
Syphilis Typhoid fever;
Infected burns and wounds.

The drug is also used to prevent bacterial diseases.

You cannot take Ceftriaxone on your own without a doctor's prescription!

In addition, in most cases, the drug is prescribed to be taken only in a hospital. At long-term treatment monitoring of the condition of the liver, kidneys and blood is required. Elderly people and people with weakened immune systems require additional vitamin K.

Contraindications and side effects

Ceftriaxone can cause a number of side effects:

Allergic reaction (rash, fever, urticaria, itching, swelling);
Headache and dizziness;
Nausea and vomiting;
Abdominal cramps, diarrhea;
Stomatitis (inflammation of the oral mucosa);
Taste disturbance;
Tachycardia and shortness of breath;
Drop in blood pressure;
Anemia;
Leukopenia.

The drug should not be used by people with high sensitivity, with renal or liver failure, or colitis. Antibiotics are not recommended for pregnant women and during lactation.

Ceftriaxone during lactation

The dose of the drug that passes into breast milk is 4.2% of the total composition of breast milk. This small proportion will not adversely affect the baby if the dosage is followed.

A safe dose for breastfeeding is 1-2 grams twice a day.

If the doctor has allowed you to combine breastfeeding and taking an antibiotic, then carefully monitor the baby’s well-being. The baby may have stomach upsets, an allergic reaction, and even poisoning. If such consequences occur, stop taking it!

The usual dosage for adults does not exceed the permissible limit for breastfeeding. The dose is 1-2 grams once a day or 0.5 - 1 gram every 12 hours.

When breastfeeding, any medication should be treated with extreme caution. Most often, during this period it is not recommended to use antibiotics to treat various diseases. The appropriateness of their use is assessed by the attending physician.

Effect of the drug

Murein is used as the main active component of Ceftriaxone. It is produced by a bacterial cell. After Ceftriaxone, it is possible to kill a large number of bacteria harmful to the mother’s body. However, some harmful cells have already developed immunity against it. In this case, the therapy will not achieve the long-awaited effect. Nursing mothers must undergo a special sensitivity test before using the drug.

Ceftriaxone is an antibiotic that is used to kill harmful bacterial cells and microorganisms. It is important to use the remedy only if this type of infection does not have developed immunity.

After the injection, you can feed the baby only seven hours later

It is advisable to use the drug in the following cases:

A severe inflammatory process in the gastrointestinal tract, which has already progressed to peritonitis.
Pneumonia or abscess in the lungs was previously diagnosed.
Infection of soft tissue, individual bones or joints.
Meningitis.
Inflammatory process in the renal pelvis (pyelonephritis).
Gonorrhea.
Infection of individual organs with microbes (sepsis) is observed in the body.
Burns and wounds that are infectious.

Contraindications for use and side effects

The drug and breastfeeding are compatible. However, there is a risk of negative manifestations.

It consists of the following symptoms:

An allergic reaction that manifests itself as a severe rash, hives, itching, or swelling.
Severe headache and dizziness.
Nausea progressing to vomiting.
Severe pain in the abdominal area accompanying diarrhea.
Inflammatory process in the oral cavity (stomatitis).
Change in taste sensations.
Periodically occurring shortness of breath or tachycardia.
Blood pressure surges.
Anemia and symptoms that are characteristic of this disease.

People with hypersensitivity to individual components should avoid taking the drug. Contraindications include renal failure, colitis and other diseases. Antibiotics should not be used during pregnancy and breastfeeding.

Parents and doctors should closely monitor the baby's condition

Features of using the drug during breastfeeding

It should be noted that a large number of tests have been carried out in this area. As a result, no negative effect or impact on the baby was identified. This is why, according to many experts, it is permissible to combine Ceftriaxone and breastfeeding. Breast milk can be replaced with formula only if a woman wants to play it safe.

When the drug penetrates into milk, it makes up no more than 4.2% of its total amount. This ratio cannot negatively affect the child and the formation of his body. Mommy is advised to strictly adhere to the dosage determined by the doctor.

The dose and frequency of injections is determined by the doctor

It has been scientifically determined that the safe amount of the drug is from one to two grams per day.

If a decision has been made to combine lactation and antibiotic treatment, then the woman should closely monitor the general condition and well-being of the baby. Side effects may include colic, allergies and diathesis. Unfortunately, cases of severe food poisoning have also been recorded. If such a reaction occurs, it is recommended to immediately stop taking it.

Parents should first of all pay attention to the baby's stool. Diarrhea is one of the common consequences that is recorded while taking Ceftriaxone.

Dosage and purpose of the drug

Most often, doctors prescribe a volume that can be administered during breastfeeding. During the day it should not exceed two grams. To obtain maximum effect, it is recommended to administer 0.5-1 grams every twelve hours.