Where is it better to inject Actovegin. Composition, form of release and packaging. Actovegin injections, instructions for use

One of the best drugs for tissue repair and improvement of metabolic processes is Actovegin. This agent is a solution containing hemoderivat from deproteinized blood of calves. Therefore, the drug is physiological for the body and is well tolerated by patients. Actovegin injections are prescribed for the treatment of many pathologies in adults and children.

General description of the drug

Actovegin is a drug with antihypoxic action. It is produced in the form of tablets, ointment and gel for external use, solution for injection and solution for droppers. The main component of the drug is hemoderivat. It is obtained from the blood of healthy calves fed only milk. It is purified from protein, leaving only small molecules that activate metabolism in the human body. And the absence of large protein molecules prevents the occurrence of allergic reactions.

Actovegin in ampoules is used for various diseases, as it acts faster than tablets. This form of release of the drug is used for intravenous and intramuscular injections. There are ampoules of 2 ml, 5 ml and 10 ml. Each milliliter of the solution contains 40 mg of hemoderivate, as well as sodium chloride and water for injection.

In the pharmacy, you can also buy a dropper solution in bottles of 250 ml. It comes in two varieties: based on dextrose with 10% active substance, as well as in physiological saline with 10 and 20% hemoderivate content.

These forms of the drug Actovegin are completely ready for use. They do not need to be diluted with anything and cannot be mixed with anything. The ampoules contain a clear yellowish liquid. If the solution has foreign impurities, and also if the tightness of the package has been broken, the medicine cannot be used. After opening the ampoule, you need to use its entire volume at a time, it is not subject to storage.

Actovegin solution is a clear yellowish liquid

Action taken

Actovegin is valued for its ability to stimulate metabolic processes, improve tissue nutrition and increase cell resistance to hypoxia. It activates the production of ATP molecules, which are necessary for the occurrence of all processes in human body. Moreover, the drug begins to act within half an hour after administration.

And this action is manifested by such therapeutic effects:

• any damage to the skin heals faster, moreover, this happens almost without scarring;
• due to activation tissue respiration reduced manifestations of circulatory disorders;
• accelerates the production of collagen fibers;
• tissue hypoxia decreases and glucose uptake improves;
• the processes of regeneration and cell division are accelerated;
• microcirculation improves due to the formation of new capillaries;
• improves energy metabolism in the brain.

Indications

Actovegin injections are often prescribed in the treatment of various diseases along with other medicines or on their own. The drug is used in neurology, cardiology, surgery, traumatology, dermatology, gynecology. It is well tolerated by patients and helps the body recover faster.

Carefully! Self-medication is unacceptable, only the doctor knows why Actovegin injections are prescribed, how to use the drug correctly and in what dosages.

This drug is used in injections more often than tablets. It is prescribed mainly for diseases caused by impaired blood circulation and metabolic processes, as well as skin damage. Actovegin injections are especially effective in complex therapy disorders of cerebral circulation. Is it hemorrhagic or ischemic stroke, encephalopathy, cerebral insufficiency, Alzheimer's disease. Often appointed similar treatment after traumatic brain injury, with dementia, memory impairment and attention due to vascular disorders.

Actovegin is effective in dementia, cerebrovascular accident, Alzheimer's disease

Injections of Actovegin also help in violation of peripheral circulation, the consequences of which are many pathologies. It could be arterial angiopathy, diabetic polyneuropathy, endarteritis, myocardial infarction. The drug is prescribed for numbness, swelling or tingling in the lower extremities.

In addition, Actovegin is widely used in dermatology and surgery. Indications for its use are as follows:

• bedsores;
• long healing wounds;
• thermal and chemical burns;
• trophic ulcers;
• surgical interventions on the organs of vision to prevent complications;
• radiation damage to the skin;
• frostbite.

Recently, Actovegin's injection solution has become in demand in cosmetology. It is used after plastic surgery, facelift, rhinoplasty. The drug helps prevent complications and accelerates tissue repair after breast augmentation, liposuction and other similar cosmetic procedures.

Actovegin injections accelerate tissue repair after chemical, thermal or radiation burns

Contraindications and side effects

The drug Actovegin contains substances natural to the body. Most often it is well tolerated when used parenterally. Therefore, it is prescribed not only for adults at any age, even the elderly, but also for children. Absolute contraindication to the use of Actovegin, only individual intolerance can become. Therefore, before starting treatment, you need to test for sensitivity to the drug.

In addition, the infusion of this drug is contraindicated in pulmonary edema, heart or kidney failure, fluid retention in the body. Droppers with a solution based on dextrose are not made for diabetes.

The drug is often prescribed during pregnancy, as it is believed that it does not negative impact to the fruit. Although the instruction refers pregnancy and lactation to contraindications. But there are some conditions in which Actovegin injections will not only alleviate the condition of a woman, but can save the life of a child. This is a violation of the blood supply to the placenta, hypoxia, a conflict between the Rh factor of the blood of the mother and the fetus, underdevelopment of the placenta, as well as some severe chronic diseases women.

Side effects for correct application Actovegina are very rare. Most often, these are allergic reactions that appear with individual intolerance to the drug. It can be pruritus, urticaria, rashes, skin hyperemia. In the most severe cases may develop angioedema or anaphylactic shock. To avoid this, the first injection should be no more than 2 ml.

Reactions from the digestive and respiratory systems appear even less frequently. Perhaps the appearance of dyspepsia, nausea, heaviness in the abdomen. Sometimes shortness of breath, difficulty breathing, heaviness in the chest develops. Other side effects are also possible: fluctuations blood pressure, tachycardia, cyanosis, paresthesia, dizziness, weakness, joint pain.

Often only local reactions can develop: pain, swelling, redness, the formation of seals. Their appearance indicates an incorrect injection or too rapid administration of the drug.

Actovegin injections are successfully used during pregnancy

Instructions for use

Actovegin for parenteral use often causes allergic reactions. Therefore, before starting treatment, a test dose of 2 ml should be administered. In the absence of negative consequences, the next injection is given at the dosage prescribed by the doctor.

It is easy to prick Actovegin intramuscularly, any person who has passed medical training. Holding the ampoule vertically, you need to tap on its tip so that the medicine is all glass down. Then break it off and draw the drug with a syringe. You need to prick in that part of the body where there is muscle tissue and less fat. Best of all is the buttocks, top part shoulder or hip.

Intramuscular injections are less effective, so they are prescribed for pathologies moderate. Most often to accelerate wound healing, in complex treatment chronic vascular diseases. Moreover, you can enter no more than 5 ml per day.

Actovegin injections intravenously should only be injected by a specialist. Usually one injection per day is prescribed, only the dosage differs. In case of violation of cerebral circulation, 10 ml of the drug is used per day for 2 weeks, then the dose is reduced to 5 ml, and the treatment continues for another month. In more severe cases, for example, with ischemic stroke, a dropper is placed with 250-500 ml of the drug. To accelerate the healing of ulcers and serious skin lesions, 1 container of Actovegin for infusions is sufficient. Instructions for use of the drug recommends continuing treatment for 10-30 days, it depends on the severity of the patient's condition.

Important: only a doctor should choose the dosage, the method of administration of the drug and the duration of therapy.

In severe cases, infusion administration of the drug is indicated.

Features of the use of the drug

It is impossible to say how to use Actovegin better: intramuscularly or intravenously. After all, the method of administration depends on the individual characteristics of the organism, the severity of the disease. Dosage and method of application is prescribed by a doctor. But intravenous injections are more effective and begin to act faster, so they are more often used in a serious condition of the patient. In addition, with this method, any amount of the drug can be administered, for example, a 10 and 20% solution in 250 ml bottles is used for a dropper. And Actovegin is administered intramuscularly in an amount of not more than 5 ml per day.

Injections should only be given by a specialist. They are very painful, so the drug should be administered very slowly, no faster than 2 ml per minute. Before injection, it is necessary to check each ampoule, since in case of violation of the transparency of the solution or the presence of impurities, the drug cannot be used. You can't store or use open ampoules.

Treatment of children

The instruction to the drug does not provide for its use for the treatment of children. But neurologists often prescribe Actovegin even to babies from the second week of life. Moreover, the drug is used precisely in injections, since it is easier to calculate the correct dosage.

Actovegin is prescribed for children with impaired cerebral circulation, with mental retardation. This can happen due to prenatal hypoxia, birth trauma. Treatment is necessary if the child twitches his neck, he has tics and convulsions, when he is placed on his legs, he relies on his fingers. At an older age, this is manifested by a lag in mental and physical development, speech delay, increased excitability.

The dosage for a child under 6 years of age is calculated individually. Babies from 1 to 3 years old for 1 kg of weight need 0.5 ml of the drug per day. From 3 to 6 years 0.2-0.4 ml daily. The drug is administered intramuscularly or intravenously. It is recommended to mix it with Novocain before injection so that the injection is less painful for the child. This is done at the rate of 1.5 ml of a 0.5% solution per 2 ml of Actovegin.

There are many drugs with a similar effect, for example, Curantil, Mexidol, Cerebrolysin or Solcoseryl. They are cheaper than Actovegin, the minimum course of treatment for which will cost at least 1000 rubles. But still, this remedy is considered the most effective for serious skin lesions and cerebrovascular accident.

For each method of application, there is a separate dosage form.

Characteristics of the drug

For the production of Actovegin, the blood of dairy calves is used, from which deproteinized hemoderivat is obtained by dialysis and ultrafiltration. It contains amino acids, macronutrients, microelements, fatty acids, oligopeptides and other important physiological components.

Having received a doctor's prescription for therapy with an ampoule form of the drug, many are wondering whether it is possible to inject Actovegin intramuscularly or whether an intravenous infusion is needed. The answer can be obtained both from a doctor or pharmacist, and by reading the leaflet to the medicine - the drug is used for intramuscular use.

Actovegin is produced in several dosage forms: injection solution, ointment, tablets, cream, infusion solution and gel. This allows each patient to choose the ideal remedy.

In particular, injections of Actovegin intramuscularly are carried out using an injection solution. It is a clear liquid that has a yellowish color or is completely colorless. The drug is sold in ampoules with a volume of 2, 5 and 10 ml. The active component in the solution is included in the amount of 40 mg per ml. Thus, 2 ml contains 80 mg of gemoderivate, 5 ml - 200 mg, and 10 ml - 400 mg. excipients water for injections and sodium chloride acts.

Medication indications

The drug has a complex mechanism of action, providing a variety of its pharmacological effects Therefore, it is used in the treatment of many diseases in various fields of medicine. Its purpose is justified, if necessary, to improve the nutrition of body tissues, increase their resistance to hypoxia, which ensures the minimum amount of damage to body cell structures in conditions of oxygen deficiency.

Actovegin according to the instructions for intramuscular injection is used for:

• abnormal dilation of cerebral vessels;
• damage to the retina;
• dyscirculatory encephalopathy;
• ischemia and oxygen starvation of organs;
• vascular atherosclerosis;
• ischemic strokes;
• vascular angiopathy;
• extensive burns of a chemical and thermal nature;
• cerebral insufficiency;
• wounds and bedsores;
• diabetic polyneuropathies;
• frostbite;
• craniocerebral injuries;
• radiation and radiation damage to the skin and mucous membranes.

How to apply

Depending on the severity of the course of the disease, intramuscular or infusion medication is prescribed. The decision on this, as well as on the dosage of the drug, is made by the doctor.

Instructions on how to administer injections intramuscularly:

• Before carrying out the manipulation, you should thoroughly wash your hands with soap and treat with an antiseptic;
• The ampoule should be slightly warmed in the hand before administration;
• Holding the ampoule vertically and having lightly tapped on it so that the entire solution is in the lower part, break off its tip along the line with a red dot;
• The medicine is drawn with a sterile syringe, then turned upside down and a drop of solution is released to make sure that all the air is out;
• Visually divide the buttock into 4 parts and insert the needle into the upper outer square, after treating the skin with a cotton swab with alcohol;
• Enter the drug slowly;
• After the injection, the injection site is clamped with cotton wool or a napkin moistened with alcohol.

In injections, according to the instructions for use, Actovegin is used at 2-5 milliliters per day. The introduction can be carried out from 1 to 3 times a day.

The attending physician, based on the presence of indications, the severity of the course of the disease and the effectiveness of the treatment, can change the recommended doses in one direction or another. If it is necessary to administer the drug in doses exceeding 5 ml, it is recommended to use Actovegin intravenously.

The following doses of the drug are usually prescribed:

• In case of circulatory insufficiency of the brain, 5 ml of the drug is used for 14 days. Next, a tablet form is prescribed to support the effect;
• To speed up the process of tissue regeneration in wounds, frostbite and other damage to the epidermis, daily injections of 5 ml of Actovegin solution are indicated. Additionally apply local forms drug - ointment, cream or gel.

Intramuscular administration is used for mild to moderate disease, while in more complex cases, infusion into a vein is required.

Precautionary measures

To ensure maximum efficiency and safety in the treatment with Actovegin in injections, it is necessary to follow the rules for its use.

Prior to the start of full-fledged therapy, the presence of individual intolerance should be determined. For this, 2 ml of the drug is injected intramuscularly for 1-2 minutes. Long-term administration allows you to observe the body's response to the drug and, with the development of anaphylaxis, you can stop the injection in time and start resuscitation of the patient.

From the above, the following rule of admission follows - injections should be given under conditions medical institution, where, if necessary, it will be possible to obtain emergency care. If home treatment is nevertheless assumed, then at least the first dose should be administered in a hospital under the supervision of medical staff.

Intramuscularly, Actovegin is allowed to be administered at a dose not exceeding 5 ml, since the solution is hypertonic and can provoke sudden jump blood pressure.

It is important to create the most sterile conditions when administering the drug. An open ampoule should be used immediately, as there are no preservatives in the medicine that would provide longer storage. Therefore, the drug should be purchased in ampoules of the volume that needs to be injected at a time. After all, storage of an opened ampoule is prohibited.

Actovegin should be stored in the refrigerator, therefore, before use, the ampoule should be slightly warmed in the hands to ensure a more comfortable administration.

A solution with a visible precipitate or cloudy should not be used. The contents of the ampoule should have a yellowish color and transparency.

It is allowed to include Actovegin in complex treatment regimens for diseases, since no negative interaction reactions with other drugs have been established. It should be borne in mind that mixing it with other drugs in the same vial or syringe is strictly prohibited. The exception is solutions of sodium chloride and glucose, which are recommended for the preparation of infusion solutions. It is also forbidden to drink alcohol during treatment with the drug.

Side effects

Actovegin is well tolerated. The most frequent negative effect during his treatment are allergic reactions, including angioedema. Much less common are:

• redness or pallor of the skin;
• dizziness;
• chest pain;
• indigestion;
• quickening and difficulty breathing;
• general weakness;
• increased blood pressure;
• pain in muscles and joints;
• increased heart rate;
• fever;
• paresthesia;
• bouts of suffocation.

If any adverse reactions of the body to the use of the drug appear, Actovegin therapy should be discontinued and symptomatic treatment should be prescribed.

When applying injections of Actovegin intramuscularly, it must be borne in mind that this is quite unpleasant and painful procedure. Therefore, its intravenous drip administration is preferable along with a solution of glucose or sodium chloride.

Contraindications

Actovegin has a high safety profile, which allows it to be used in a wide range of patients. However, there are exceptions. Injections of Actovegin intramuscularly are prohibited when:

• hypersensitivity to the components of the remedy;
• heart failure;
• violations of the outflow of urine;
• pulmonary edema;
• kidney diseases.

The use of the drug in special groups of patients

According to the instructions, in pediatrics the drug should not be prescribed due to the lack of enough relevant research. But in practice, many doctors use Actovegin to treat infants and children.

Intramuscular injections of the drug are practically not used in this category of patients due to the painfulness of the procedure. An exception are infants with the consequences of intrauterine hypoxia. But such injections are administered only in a hospital under constant medical supervision.

Pregnant women Actovegin is prescribed with caution, after evaluation possible consequences for the fetus. If it is necessary to administer the drug to such patients, preference is given to intravenous administration at the beginning of treatment with a further transition, when the condition improves, to intramuscular administration or taking tablets.

Indications for the appointment are: the threat of abortion, feto-placental insufficiency, placental abruption, Rhesus conflict, slowing down weight gain by the fetus or its low physical activity.

The use of the drug during lactation is also allowed, but only if its therapeutic effect on the mother's body exceeds potential risk for the breast.

In geriatrics, the drug is used quite often. At the same time, judging by the reviews, it is in the elderly and old age positive influence Actovegina appears best.

Found an error? Select it and press Ctrl + Enter

IMPORTANT. The information on the site is provided for reference purposes only. Do not self-medicate. At the first sign of disease, consult a doctor.

All about Actovegin

All about unique preparation- actovegin

Pages

Actovegin - injections. Video. Instructions for injections

So why is an injection sometimes better than a pill?

The injection has a sister - this is a dropper, which is used when you need to inject a lot of medication and it should be administered only gradually.

With the help of a syringe, a solution is drawn from the ampoule (in order to avoid air ingress, it is necessary to release a drop of the solution, holding the syringe with the needle up).

Naturally, everything must be sterile ( here you can see video).

Or: five ml of the solution of the drug in / in - between therapy sessions.

Therefore, in such a situation, treatment with Actovegin is suspended and antihistamine (and, if necessary, corticosteroid) treatment is carried out.

Actovegin injections intramuscularly: inject slowly no more than 5 ml (because this medicinal product hypertensive).

Injections can be done both in the morning and in the evening.

Children - highly undesirable, but in practice (in exceptional cases) make injections of Actovegin. In this case, the doctor evaluates all risks.

After opening the vial or ampoule, the Actovegin solution cannot be stored and then reused for injections: this will not only have no effect, but is simply dangerous to health.

With frequent use of Actovegin injections in patient therapy, it is necessary to check the electrolyte composition of the serum (K, Na, Ca, Cl, Mg.), As well as water balance the patient's body.

Treatment with Actovegin can be carried out only after consulting a doctor.-specialist and only after examining the patient. Neither self-treatment nor consultations given in absentia are recommended, tk. this can lead to complications.

Nevertheless, you can read reviews about Actovegin injections.

Actovegin also comes in the form of tablets, gel, ointment.

Keep ampoules should be in a dark place with room temperature(not higher than 25 ° C), in the package, out of the reach of children.

You may be interested in the general instructions for the use of Actovegin, the compatibility of Actovegin with other medicines, reviews of Actovegin by our readers, the price and manufacturers of the drug (and also its analogue Solcoseryl), the use of Actovegin in sports and in veterinary medicine (for the treatment of our pets).

You will find answers to these and many other questions on our website.

What time of day is best to inject Actovegin

Development of a child with MR (completed).

Thanks for the ideas, we'll implement it right now 🙂

Well, actually, everything is simple, he will need chirping when others around him will not understand him without chirping;) Ie. any information being studied should be applied in everyday life: “Go get me 2 + 2 pencils. find an object with the letter A. make a “cake” from the letters and get a piece. "and other garbage in the current daily life.

Before pregnancy, I never had problems with veins.

Before pregnancy, I never had problems with veins, they were always smooth and slender legs. And as soon as I got pregnant, it immediately became difficult to walk in heels, although my stomach was not yet visible. Further - worse. The legs began to swell, pouring lead, hurt at night. At first, the gynecologist said that this is normal for the expectant mother, because the load increases, but when I began to get out vascular network It became clear that the matter was serious. Then I specifically asked the doctor about how.

Harm of pills to the fetus. Barinvakti's blog on 7ya.ru

Hello, I'm very worried, I live abroad, I have 5.5 weeks, severe spasms, the doctor said there was a threat of miscarriage, and they prescribed me 3 injections of progesterone, progesterone suppositories and spasmalgon (2 tablets 3 times a day). In almost 2 days I received 3 injections of progesterone. After the third shot of progesterone, I fainted and my cramping pains got much worse. I have questions: could there be an overdose of progesterone? What causes spasms to hurt? On ultrasound, the doctor said that the fetus was well attached.

When to start injecting? Botox and hyaluronic acid at 20, 40.

Wrinkle cream, Botox or hyaluronic acid injections

Hypertensive crisis: are our parents treated correctly.

Treatment of hypertensive crisis. How do hypertension medications work?

My daughter's birthday.

And flew. 4:30 They shake me by the leg, spread their arms with the word "Everything." I still do not understand anything, because I want to sleep deadly after sleepless night wallpaper pasting. Somehow I wake up. Alenka explains to me that the mucus plug has finally come off and she is having contractions. In general, the fact that the cork has finally departed is a harbinger, but it can still calmly take a few days before the birth. Yes, and contractions may well be trial (by the way, we have already been sitting with such trials in the country for an hour since.

For those who have missing apples.

It is very strange, but for some reason, none of my friends know that you can make a wonderful marshmallow thing from apples. Which is incredibly pleasant to chew in winter and remember about summer and childhood :)) For me, this is exactly the taste of childhood. My grandmother always prepared this delicacy for the winter. In general, if you have formed inedible padanki or just extra apples, then I recommend making marshmallow. The cooking process is simple to obscene. Peel the apples from the skin and core, cut into pieces and.

Just pour mashed potatoes on parchment and smooth with a spatula?

And then what thickness should this puree be initially? :)))))

I need to do this ASAP!!!

Israeli cosmetics Lamerel - an alternative to injections?.

Good day! I tried the other day a new cosmetics Lamerel from Israel - a cream with a lifting effect. I was pleasantly surprised - the effect is quick and pleasant (the oval of the face somehow tightened up, the color refreshed, the skin seemed to be from a vacation). Here I sit, racking my brains - what to do when it runs out - where can I buy Lamerel cosmetics in St. Petersburg? Fly back to Eilat for her? Write, who knows what and who else has tried this cosmetics?

If necessary, I'll poke. Vaccination (vaccinations) | How vaccinations are made

Post-vaccination reactions occur much more often, but they do not cause harm to health and, as a rule, do not require treatment. These include: An increase in temperature up to ° C in the first three days after vaccination. In this case, suppositories, tablets or syrup with paracetamol or ibuprofen help well. Attention! It is not recommended to use aspirin to lower the temperature! Also, you can not take this drug within a month after vaccination against chickenpox - this threatens with severe liver damage. In the case of the use of live vaccines, on the 7-14th day after vaccination, the development of a “disease in miniature” is possible (a rash appears, the joint swells.

Nutrition of children with pathological regurgitation syndrome.

Almost all new mothers are worried that their babies spit up after feeding. This is usually caused by aerophagia (air entering the esophagus during sucking). This is completely normal for babies.

Cesarean section: recover without loss! C-section

Recovery after caesarean section

Drugs for placental insufficiency. Vitamins.

Based on a comprehensive examination, a conclusion is made not only about the fact of the presence or absence of placental insufficiency, but also about the severity of such a violation. The tactics of conducting pregnancy with different degrees of severity of placental insufficiency is different. Prevention and treatment Currently, unfortunately, it is not possible to completely rid a pregnant woman of placental insufficiency that has arisen by any therapeutic effects. The applied means of therapy can only contribute to the stabilization of the existing pathological process and maintaining compensatory-adaptive mechanisms at a level that allows to ensure the continuation of pregnancy until the optimal term of delivery. Therefore, it is very important to carry out prophylaxis in women with risk factors for the development of placenta.

Actovegin increases the resistance of the brain and fetal tissues to hypoxia, activates metabolism, increases glucose consumption, and stimulates the renewal of fetal cells. In addition, the drug enhances blood circulation in the mother-placenta-fetus system, contributes to better fetal tolerance. birth act. Treatment with Actovegin has pronounced effect on the condition of the fetus. This is reflected in improved blood flow and improved fetal growth, which reduces the frequency of forced early delivery. The drug is obtained from the blood of calves, has a minimum of side effects, a rather rare occurrence of allergic reactions has been noted. Contraindications to the use of the drug is heart failure.

Mom gives injections - help is needed. We need your experience and knowledge.

Who has experience in this matter? I need your help, otherwise my brain will boil now 🙁 We prescribed a course of treatment for the child, prescribed a bunch of medicines, incl. you need to give injections: 1. Cerebrolysin 1.0 ml intramuscularly 2. Actovegin 2.0 ml intramuscularly 3. Neuromidin 5 mg, 0.5 ml intramuscularly to myself. I am terribly afraid, while in my life I have never given injections myself. I have experience only in breeding Cortexin injections and, accordingly, I saw where to inject and how to inject. Those. With.

To mothers of restless children: PEP - myths and reality.

You can minimize the time of mother's "lack of sleep" with the help of rational organization co-sleeping and night feedings. Babies often sleep better next to their mothers. Motion sickness can also be replaced by applying to the chest before going to bed. When I learned that it was “possible” to do this, the time of motion sickness was significantly reduced. Children often wake up after sleeping in bad mood, you can also offer a breast, and the world will delight the baby again! Secondly, this is the assignment to pathological of a number of adaptive, passing phenomena from the outside. nervous system newborn (for example, startling or throwing up arms and legs, trembling of the chin with excessive crying or.

©, 7ya.ru, Mass media registration certificate El No. FS.

Reprinting messages from conferences is prohibited without specifying a link to the site and the authors of the messages themselves. Reprinting materials from other sections of the site is prohibited without the written consent of ALP-Media and the authors. The opinion of the editors may not coincide with the opinion of the authors. The rights of authors and the publisher are protected. Technical support and IT outsourcing is carried out by KT-ALP.

7ya.ru - information project on family issues: pregnancy and childbirth, parenting, education and career, home economics, recreation, beauty and health, family relationships. Thematic conferences, blogs work on the site, ratings of kindergartens and schools are maintained, articles are published daily and competitions are held.

If you find errors, malfunctions, inaccuracies on the page, please let us know. Thank you!

Actovegin - instructions for use (injections, tablets, ointment, gel, cream). Why is Actovegin prescribed?

Varieties, names, composition and forms of release

Actovegin is currently available in the following dosage forms (which are also sometimes called varieties):

• Gel for external use;
• Ointment for external use;
• Cream for external use;
• Solution for infusions ("droppers") on dextrose in 250 ml bottles;
• Solution for infusion in 0.9% sodium chloride (in saline) in 250 ml bottles;
• Solution for injection in ampoules of 2 ml, 5 ml and 10 ml;
• Tablets for oral administration.

Gel, cream, ointment and Actovegin tablets do not have any other everyday simplified name. But forms for injection in everyday life are often called simplified names. So, the injection solution is often called "Actovegin ampoules", "Actovegin injections", as well as "Actovegin 5", "Actovegin 10". In the names "Actovegin 5" and "Actovegin 10" the numbers mean the number of milliliters in an ampoule with a solution ready for administration.

• Gel Actovegin - contains 20 ml of gemoderivate (0.8 g in dried form) in 100 ml of gel, which corresponds to 20% concentration of the active ingredient.
• Ointment and cream Actovegin - contain 5 ml of gemoderivate (0.2 g in dried form) in 100 ml of ointment or cream, which corresponds to 5% concentration of the active ingredient.
• Solution for infusion in dextrose - contains 25 ml of hemoderivate (1 g in dried form) per 250 ml of a ready-to-use solution, which corresponds to an active ingredient concentration of 4 mg / ml or 10%.
• Solution for infusion in 0.9% sodium chloride - contains 25 ml (1 g dried) or 50 ml (2 g dried) hemoderivat per 250 ml ready-to-use solution, which corresponds to an active ingredient concentration of 4 mg / ml ( 10%) or 8 mg/ml (20%).
• Solution for injection - contains 40 mg of dry hemoderivat per 1 ml (40 mg / ml). The solution is available in ampoules of 2 ml, 5 ml and 10 ml. Accordingly, ampoules with 2 ml of solution contain 80 mg of the active ingredient, with 5 ml of solution - 200 mg and with 10 ml of solution - 400 mg.
• Tablets for oral administration - contain 200 mg of dry hemoderivate.

All dosage forms of Actovegin (ointment, cream, gel, solutions for infusions, solutions for injections and tablets) are ready to use and do not require any preparation before use. This means that the ointment, gel or cream can be applied immediately after opening the package, the tablets can be taken without preparation. Solutions for infusion are administered intravenously (“dropper”) without prior dilution and preparation, simply by placing a bottle in the system. And injection solutions are also administered intramuscularly, intravenously or intra-arterially without preliminary dilution, simply by choosing an ampoule with the required amount of milliliters.

• Mountain wax glycolate;
• Titanium dioxide;
• Diethyl phthalate;
• Dried gum arabic;
• Macrogol 6000;
• Microcrystalline cellulose;
• Povidone K90 and K30;
• Sucrose;
• magnesium stearate;
• Talc;
• Dye quinoline yellow varnish aluminum (E104);
• Hypromellose phthalate.

The composition of the auxiliary components of the gel, ointment and cream Actovegin is shown in the table below:

Cream, ointment and gel Actovegin are available in aluminum tubes of 20 g, 30 g, 50 g and 100 g. The cream and ointment are a homogeneous white mass. Gel Actovegin is a transparent yellowish or colorless homogeneous mass.

The volume of Actovegin ampoules in ml

Actovegin solution in ampoules is intended for intravenous, intra-arterial and intramuscular injections. The solution in ampoules is ready for use, so to make an injection, you just need to open the ampoule and draw the medicine into the syringe.

Therapeutic action

Actovegin is a universal stimulant of metabolism, which leads to a significant improvement in tissue nutrition and the utilization of glucose from the blood for the needs of the cells of all organs. In addition, Actovegin increases the resistance of cells of all organs and tissues to hypoxia, as a result of which, even under conditions oxygen starvation damage to cellular structures is minimally expressed. The general, total effect of Actovegin is to increase the production of energy molecules (ATP) necessary for the flow of all vital processes in the cells of any organ.

• The healing of any tissue damage (wounds, incisions, cuts, abrasions, burns, ulcers, etc.) and their restoration is accelerated normal structure. That is, under the action of Actovegin, any wounds heal easier and faster, and the scar is formed small and inconspicuous.
• The process of tissue respiration is activated, which leads to a more complete and rational use of oxygen delivered with blood to the cells of all organs and tissues. Due to the more complete use of oxygen, the Negative consequences insufficient blood supply to tissues.
• The process of using glucose by cells that are in a state of oxygen starvation or metabolic depletion is stimulated. And this means that on the one hand, the concentration of glucose in the blood decreases, and on the other hand, tissue hypoxia decreases due to the active use of glucose for tissue respiration.
• Improves the synthesis of collagen fibers.
• The process of cell division is stimulated with their subsequent migration to areas where it is necessary to restore the integrity of the tissue.
• Growth is stimulated blood vessels, which leads to improved blood supply to tissues.

The effect of Actovegin on enhancing glucose utilization is very important for the brain, since its structures need this substance more than all other organs and tissues of the human body. After all, the brain uses mostly glucose for energy production. Actovegin also contains inositol phosphate-oligosaccharides, the effect of which is similar to that of insulin. And this means that under the action of Actovegin, the transportation of glucose to the tissues of the brain and other organs improves, and then this substance is quickly captured by cells and utilized for energy production. Thus, Actovegin improves energy metabolism in the structures of the brain and provides its needs for glucose, thereby normalizing the work of all parts of the central nervous system and reducing the severity of cerebral insufficiency syndrome (dementia).

Indications for use (Why is Actovegin prescribed?)

Various dosage forms of Actovegin are indicated for use in various diseases, therefore, to avoid confusion, we will consider them separately.

• Acceleration of wound healing and inflammatory processes on the skin and mucous membranes (abrasions, cuts, scratches, burns, cracks);
• Improving tissue repair after burns of any origin ( hot water, ferry, solar, etc.);
• Treatment of weeping ulcers skin any origin (including varicose ulcers);
• Prevention and treatment of reactions to the effects of radiation exposure (including radiation therapy of tumors) from the skin and mucous membranes;
• Prevention and treatment of bedsores (only for Actovegin ointment and cream);
• For pre-treatment wound surfaces before skin grafting in the treatment of extensive and severe burns (only for Actovegin gel).

Solutions for infusions and solution for injections (shots) Actovegin - indications for use. Solutions for infusions ("droppers") and solutions for injections are indicated for use in the same following cases:

• Treatment of metabolic and vascular disorders of the brain (for example, ischemic stroke, the consequences of a traumatic brain injury, impaired blood flow in brain structures, as well as dementia and impaired memory, attention, ability to analyze due to vascular diseases of the central nervous system, etc.);
• Treatment of peripheral vascular disorders, as well as their consequences and complications (for example, trophic ulcers, angiopathy, endarteritis, etc.);
• Treatment of diabetic polyneuropathy;
• Healing of wounds of the skin and mucous membranes of any nature and origin (for example, abrasions, cuts, incisions, burns, bedsores, ulcers, etc.);
• Prevention and treatment of lesions of the skin and mucous membranes when exposed to radiation, including radiation therapy of malignant tumors;
• Treatment of thermal and chemical burns(only for solutions for injections);

Actovegin tablets - indications for use. Tablets are indicated for use in the treatment of the following conditions or diseases:

• As part of the complex therapy of metabolic and vascular diseases of the brain (for example, cerebrovascular insufficiency, traumatic brain injury, as well as dementia due to vascular and metabolic disorders);
• Treatment of peripheral vascular disorders and their complications (trophic ulcers, angiopathy);
• Diabetic polyneuropathy;
• Hypoxia of organs and tissues of any origin (this indication is approved only in the Republic of Kazakhstan).

Instructions for use

Ointment, cream and gel Actovegin - instructions for use

Various dosage forms of Actovegin for external use (gel, cream and ointment) are used for the same conditions, but at different stages of these diseases. This is due to various auxiliary components that give different properties gel, ointment and cream. Therefore, gel, cream and ointment provide scarring of wounds at various stages of healing with different types of wound surfaces.

• If the wound is weeping with copious discharge, then the gel should be used until the wound surface dries. When the wound dries up, it is necessary to switch to the use of a cream or ointment.
• If the wound is moderately wet, the discharge is poor or moderate, then a cream should be used, and after the wound surface has completely dried, switch to the use of an ointment.
• If the wound is dry, without discharge, then an ointment should be applied.

Rules for the treatment of wounds with gel, cream and ointment Actovegin

Actovegin tablets - instructions for use (adults, children)

Tablets are intended for use in the same conditions and diseases as injectable solutions. However, the severity therapeutic effect with parenteral administration of Actovegin (injections and "droppers") is stronger than when taking the drug in tablet form. That is why many doctors recommend always starting treatment with parenteral administration Actovegin with a subsequent transition to taking tablets as a fixing therapy. That is, at the first stage of therapy, in order to quickly achieve the most pronounced therapeutic effect, it is recommended to administer Actovegin parenterally (by injections or "droppers"), and then additionally drink the drug in tablets to consolidate the effect achieved by injections for a long period of time.

Actovegin injections - instructions for use

Dosages and general rules application of Actovegin solutions

Figure 2 - The correct break off of the tip of the ampoule to open it.

• metabolic and vascular disorders work of the brain (traumatic brain injury, cerebrovascular insufficiency) - 5-25 ml of solution is administered daily for two weeks. After completing the course of injections of Actovegin, they switch to taking the drug in tablets in order to maintain and consolidate the achieved therapeutic effect. In addition, instead of switching to a maintenance pill, you can continue injecting Actovegin by injecting 5-10 ml of the solution intravenously 3-4 times a week for two weeks.
• Ischemic stroke - Actovegin is administered by infusion ("dropper"), adding 20 - 50 ml of solution from ampoules to 200 - 300 ml physiological saline or 5% dextrose solution. In this dosage, the drug is infused daily for a week. Then in 200 - 300 ml infusion solution(saline or dextrose 5%) add 10-20 ml of Actovegin solution from ampoules and inject at this dosage daily in the form of "droppers" for another two weeks. After completing the course of "droppers" with Actovegin, they switch to taking the drug in tablet form.
• Angiopathy (peripheral vascular disorders and their complications, for example, trophic ulcers) - Actovegin is administered by infusion ("dropper"), adding 20-30 ml of the solution from the ampoules to 200 ml of saline or 5% dextrose solution. In this dosage, intravenous infusion, the drug is administered daily for four weeks.
• Diabetic polyneuropathy - Actovegin is administered intravenously, 50 ml of a solution from ampoules, daily for three weeks. After completing the course of injections, they switch to taking Actovegin in the form of tablets for 4 to 5 months to maintain the achieved therapeutic effect.
• Healing of wounds, ulcers, burns and other wound injuries of the skin - a solution is injected from ampoules of 10 ml intravenously or 5 ml intramuscularly either daily or 3-4 times a week, depending on the rate of healing of the defect. In addition to injections, Actovegin can be used in the form of an ointment, cream or gel to accelerate wound healing.
• Prevention and treatment radiation injury(during radiation therapy of tumors) of the skin and mucous membranes - Actovegin is injected with 5 ml of a solution from ampoules intravenously daily, in between sessions of radiation therapy.
• Radiation cystitis - inject 10 ml of a solution from ampoules transurethral (through the urethra) daily. Actovegin in this case used in combination with antibiotics.

Rules for the introduction of Actovegin intramuscularly

Actovegin solution for infusion - instructions for use

Solutions for infusion Actovegin are available in two varieties - in saline or dextrose solution. There is no fundamental difference between them, so you can use any version of the finished solution. Such solutions of Actovegin are available in 250 ml bottles in the form of a ready-to-use infusion (“dropper”). Solutions for infusion are administered intravenously by drip (“dropper”) or intra-arterially by jet (from a syringe, as intramuscularly). Drip injection into a vein should be carried out at a rate of 2 ml / min.

• Circulatory and metabolic disorders in the brain (traumatic brain injury, lack of blood supply to the brain, etc.) - 250-500 ml (1-2 bottles) are administered once a day, daily for 2-4 weeks. Further, if necessary, in order to consolidate the obtained therapeutic effect, they switch to taking Actovegin tablets, or continue to inject the solution intravenously, 250 ml (1 bottle) 2-3 times a week for another 2 weeks.
• Acute disorders of cerebral circulation (stroke, etc.) - 250 - 500 ml (1 - 2 bottles) are administered once a day, daily, or 3 - 4 times a week for 2 - 3 weeks. Further, if necessary, they switch to taking Actovegin tablets in order to consolidate the obtained therapeutic effect.
• Angiopathy (impaired peripheral circulation and its complications, for example, trophic ulcers) - 250 ml (1 vial) is administered once a day, daily, or 3-4 times a week for 3 weeks. Simultaneously with the "droppers" you can apply Actovegin externally in the form of an ointment, cream or gel.
• Diabetic polyneuropathy - 250 - 500 ml (1 - 2 bottles) are administered once a day, daily, or 3 - 4 times a week for 3 weeks. Next, be sure to switch to taking Actovegin tablets in order to consolidate the resulting therapeutic effect.
• Trophic and other ulcers, as well as long-term non-healing wounds of any origin - 250 ml (1 bottle) is administered once a day, daily, or 3-4 times a week, until the wound defect is completely healed. Simultaneously with infusion administration, Actovegin can be used topically in the form of a gel, cream or ointment to accelerate wound healing.
• Prevention and treatment of radiation damage (during radiation therapy of tumors) of the skin and mucous membranes - 250 ml (1 vial) is administered one day before the start, and then daily during the entire course of radiation therapy, and additionally for another two weeks after last irradiation session.

special instructions

With repeated intravenous, intramuscular or intra-arterial administration of Actovegin, the level of blood electrolytes (calcium, potassium, sodium, chlorine) and the percentage of water in the body (hematocrit) should be monitored.

Overdose

In Russian official instructions according to the application, there are no indications of the possibility of overdose with any dosage forms of Actovegin. However, in the instructions approved by the Ministry of Health of Kazakhstan, there are indications that when using tablets and solutions of Actovegin, an overdose may occur, which is manifested by pain in the stomach or increased side effects. In such cases, it is recommended to cancel the use of the drug, perform a gastric lavage and carry out symptomatic therapy aimed at maintaining the normal functioning of vital organs and systems.

Influence on the ability to control mechanisms

No dosage form of Actovegin (ointment, cream, gel, tablets, solutions for injections and solutions for infusions) affects the ability to control mechanisms, therefore, against the background of the use of the drug in any form, a person can engage in any type of activity, including those requiring high speed of reactions and concentration of attention.

Interaction with other drugs

Forms of Actovegin for external use (gel, cream and ointment) do not interact with other drugs. Therefore, they can be used in combination with any other means for oral administration (tablets, capsules) and for local use(creams, ointments, etc.). Only if Actovegin is used in combination with other external agents (ointments, creams, lotions, etc.), a half-hour interval should be maintained between the applications of the two preparations, and not smeared immediately after each other.

Actovegin is a drug that activates metabolism, improves tissue nutrition, reduces tissue hypoxia and stimulates regeneration. Is it possible to inject Actovegin intramuscularly? Doctors of the Yusupov hospital prescribe Actovegin in the form of intramuscular and intravenous injections, infusions. The drug can be taken orally in the form of tablets. Ointments, creams and gels of actovegin are applied to the skin.

The drug is used in endocrinology, neurology, vascular surgery, obstetrics and pediatrics. In the Yusupov hospital, before prescribing Actovegin intramuscularly, doctors conduct a comprehensive examination of the patient using modern diagnostic equipment from leading manufacturers and laboratory methods diagnostics. The drug is administered intramuscularly according to the instructions for use of actovegin. Doctors individually determine the route of administration of the drug, the dose and duration of therapy.

Instructions for use Actovegin

Actovegin solution is administered intramuscularly, which is in ampoules of 2 or 5 ml. Ampoules containing 10 ml are not used for intramuscular injection, since the maximum allowable dose of the drug that can be injected into the muscle is 5 ml, and the contents of the opened ampoule cannot be stored.

One milliliter of the solution contains 40 mg of the main active ingredient - purified calf blood extract, 2 ml - 80 mg, 5 ml - 200 mg. The active substance actovegin contains the following components:

• Amino acids;
• Macronutrients;
• Microelements;
• Fatty acid;
• Oligopeptides.

An auxiliary ingredient is water for injection and sodium chloride. Actovegin solution is a clear, colorless or yellowish liquid. When it becomes cloudy or flakes form, the drug is not administered intramuscularly.

Indications and contraindications for intramuscular administration of actovegin

Actovegin has a complex mechanism of action, which provides a variety of its pharmacological effects. It is used in the treatment of many diseases. His doctors at the Yusupov hospital prescribe, if necessary, to improve the nutrition of body tissues and increase their resistance to hypoxia. This ensures minimal damage to body cells in conditions of insufficient oxygen supply.

Actovegin, according to the instructions, is administered intramuscularly in the presence of the following indications:

• Transient disorders of cerebral circulation;
• Ischemic stroke;
• Encephalopathy;
• Cerebral atherosclerosis;
• angiopathy;
• Diabetic polyneuropathy.

Intramuscular injections of actovegin are indicated for frostbite, burns, trophic ulcers. The drug is administered intramuscularly to patients suffering from obliterating peripheral vascular diseases, varicose disease, diabetic angiopathy. Doctors prescribe intramuscular injections of actovegin for mild or moderate diseases.

How to administer Actovegin intramuscularly

How to inject Actovegin intramuscularly? Nurses Yusupov hospital when performing under intramuscular injection actovegin strictly adhere to the instructions for use of the drug. Intramuscular injections of the drug are made according to the algorithm:

• Before carrying out the manipulation, wash your hands thoroughly with soap and treat with an antiseptic solution;
• Put on sterile disposable gloves;
• An ampoule with actovegin is warmed in the hand, wiped with alcohol;
• The ampoule is held vertically, with light tapping of the fingers on it they make sure that the entire solution is in the lower part, break off its tip along the line with a red dot;
• The solution is drawn into a disposable sterile syringe, air is released;
• Visually divide the buttock into 4 parts and insert the needle into the outer upper square, after treating the skin with a cotton swab with alcohol;
• The drug is administered slowly;
• After the injection, the injection site is clamped with a napkin or cotton ball moistened with alcohol.

Recommended doses of actovegin for intramuscular injection

According to the instructions for the use of Actovegin, 2-5 ml of the drug can be administered intramuscularly. The attending physician, taking into account the indications, the severity of the course of the disease and the effectiveness of the treatment, may change the recommended doses. In diseases of the central nervous system, 5 ml of actovegin is usually administered daily for two weeks. Then doctors prescribe Actovegin tablets in maintenance doses.

To accelerate the process of tissue regeneration in wounds, frostbite and other damage to the epidermis, daily intramuscular injections of 5 ml of actovegin solution are indicated. Additionally, the following pharmacological forms medication, such as a gel, ointment, or cream. Actovegin is administered intramuscularly for mild to moderate severity of the course of the disease. In more complex cases, doctors prescribe intravenous injections or infusions of the drug.

Precautions for intramuscular administration of actovegin

To ensure maximum efficiency and safety in the treatment with actovegin, individual intolerance to the drug is determined at the beginning of therapy. For this, 2 ml of the drug is injected intramuscularly for 1-2 minutes. Long-term administration allows you to observe the body's response to the drug and, with the development of allergic reactions, stop the injection in time. Treatment rooms at the Yusupov Hospital are equipped with an anti-shock kit, which allows immediate emergency care to be provided to the patient.

The use of disposable syringes, modern antiseptic solutions, allows you to protect the patient from infection with pathogens of infectious diseases that are transmitted with blood. Nurses are fluent in the technique of intramuscular injections. An open ampoule is used immediately, since the absence of preservatives in the solution does not allow it to be stored. long time. For this reason, patients are advised to purchase ampoules of the volume that is administered once.

Actovegin is stored in the refrigerator. Before using the drug, the ampoule is slightly warmed in the hands to ensure a more comfortable administration. A solution that is cloudy or contains a visible precipitate is not used. As evidenced by the instructions for the use of actovegin, children can be injected with the drug intramuscularly from the age of three.

You can enter Mexidol and Actovegin together intramuscularly. The treatment regimen is determined by the doctor. During treatment with Actovegin, doctors recommend that patients stop drinking alcohol. In order to get advice on the use of Actovegin, call us.

Bibliography

• ICD-10 ( International classification diseases)
• Yusupov hospital
• Badalyan L. O. Neuropathology. - M.: Enlightenment, 1982. - S.307-308.
• Bogolyubov, medical rehabilitation(manual, in 3 volumes). // Moscow - Perm. - 1998.
• Popov S. N. Physical rehabilitation. 2005. - P.608.

Service prices *

*The information on the site is for informational purposes only. All materials and prices posted on the site are not a public offer, determined by the provisions of Art. 437 of the Civil Code of the Russian Federation. For exact information, please contact the clinic staff or visit our clinic. List of rendered paid services listed in the price list of the Yusupov hospital.

*The information on the site is for informational purposes only. All materials and prices posted on the site are not a public offer, determined by the provisions of Art. 437 of the Civil Code of the Russian Federation. For exact information, please contact the clinic staff or visit our clinic.

Actovegin belongs to the well-known medication With a wide range consumption.

A medicine is used to treat metabolic and vascular changes in the brain, burns, bedsores, with chronically increased sugar in adults, children, during childbearing and lactation. Price for this medicine quite high and inaccessible to most categories of people, therefore they produce analogues of Actovegin, much cheaper than the official product.

On this page you will find all the information about Actovegin: complete instructions on application to this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Actovegin in the form of injections. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

A drug that activates the metabolism in tissues, improves trophism and stimulates the regeneration process.

Terms of dispensing from pharmacies

Injections and tablets are available by prescription. Ointment, cream, gel - without a prescription.

Prices

How much do Actovegin ampoules cost? average price in pharmacies is at the level of 650 rubles.

Release form, composition and packaging

There are the following forms of the drug:

• Actovegin tablets have a round biconvex shape, covered with a yellow-green shell. Packed in dark glass bottles of 50 pieces.
• Solution for injection 2 ml, 5.0 No. 5, 10 ml No. 10. It is contained in colorless glass ampoules that have a breaking point. Packed in a blister pack of 5 pieces.
• The solution for infusion (Actovegin intravenously) is placed in 250 ml bottles, which are corked and placed in a cardboard box.
• Cream Actovegin is packaged in tubes of 20 g.
• Gel Actovegin 20% is packaged in tubes of 5 g.
• Actovegin eye gel 20% is packaged in tubes of 5 g.
• Ointment 5% is packaged in tubes of 20 g.

This tool contains as active substance deproteinized hemoderivate from calf blood. The injection also contains sodium chloride and water as additional substances. OKPD code 24.42.13.815.

pharmachologic effect

Actovegin is a universal stimulant of metabolism, which leads to a significant improvement in tissue nutrition and the utilization of glucose from the blood for the needs of the cells of all organs. In addition, Actovegin increases the resistance of cells of all organs and tissues to hypoxia, as a result of which, even under conditions of oxygen starvation, damage to cellular structures is minimally expressed. The general, total effect of Actovegin is to increase the production of energy molecules (ATP) necessary for the flow of all vital processes in the cells of any organ.

The overall effect of Actovegin, which consists in improving energy metabolism and increasing resistance to hypoxia, at the level various bodies and tissues is manifested by the following therapeutic effects:

1. Improves the synthesis of collagen fibers.
2. The process of cell division is stimulated with their subsequent migration to areas where it is necessary to restore the integrity of the tissue.
3. The growth of blood vessels is stimulated, which leads to an improvement in the blood supply to tissues.
4. The healing of any tissue damage (wounds, incisions, cuts, abrasions, burns, ulcers, etc.) and the restoration of their normal structure are accelerated. That is, under the action of Actovegin, any wounds heal easier and faster, and the scar is formed small and inconspicuous.
5. The process of tissue respiration is activated, which leads to a more complete and rational use of oxygen delivered with blood to the cells of all organs and tissues. Due to a more complete use of oxygen, the negative consequences of insufficient blood supply to tissues are reduced.
6. The process of using glucose by cells that are in a state of oxygen starvation or metabolic depletion is stimulated. And this means that on the one hand, the concentration of glucose in the blood decreases, and on the other hand, tissue hypoxia decreases due to the active use of glucose for tissue respiration.

The effect of Actovegin on enhancing glucose utilization is very important for the brain, since its structures need this substance more than all other organs and tissues of the human body. After all, the brain uses mostly glucose for energy production. Actovegin also contains inositol phosphate-oligosaccharides, the effect of which is similar to that of insulin. And this means that under the action of Actovegin, the transportation of glucose to the tissues of the brain and other organs improves, and then this substance is quickly captured by cells and utilized for energy production. Thus, Actovegin improves energy metabolism in the structures of the brain and provides its needs for glucose, thereby normalizing the work of all parts of the central nervous system and reducing the severity of cerebral insufficiency syndrome (dementia).

In addition, improving energy metabolism and increased glucose utilization leads to a decrease in the severity of symptoms of circulatory disorders in any other tissues and organs.

What helps Actovegin?

Actovegin can be prescribed for many painful conditions. Its use is justified in such diseases:

• radiation, thermal, solar, chemical burns up to 3 degrees;
• peripheral diabetic polyneuropathy;
• trophic damage;
• wounds of various origins that are difficult to treat;
• ulcerative skin lesions;
• therapy and residual effects after it;
• encephalopathies of different origin;
• failures observed in the work of venous, peripheral or arterial blood;
• various craniocerebral injuries;
• angiopathy, especially of diabetic origin;
• emerging bedsores;
• damage to the mucous membranes and skin, provoked by radiation damage;
• radiation neuropathies.

Contraindications

Contraindications to the use of the drug are the following conditions:

• pulmonary edema;
• , anuria;
• fluid retention in the body;
• children's and adolescence up to 18 years;
• hypersensitivity to the drug Actovegin, similar drugs or excipients;
• decompensated heart failure.

Pregnancy

During pregnancy and lactation, Actovegin should be used only in cases where the therapeutic benefit outweighs the potential risk to the fetus or child.

Instructions for use Actovegin

The instructions for use indicate that Actovegin is used intravenously, intravenously (including as an infusion) and intramuscularly.

• Depending on the severity clinical picture first, 10-20 ml of the drug should be administered intravenously or intravenously daily; then - 5 ml in / in or / m slowly, daily or several times a week.

For infusion administration, from 10 to 50 ml of the drug should be added to 200-300 ml of the stock solution (isotonic sodium chloride solution or 5% glucose solution). The infusion rate is about 2 ml / min.

For intramuscular injections, no more than 5 ml of the drug is used, which should be administered slowly, since the solution is hypertonic.

• AT acute period ischemic stroke (starting from 5-7 days) - 2000 mg / day intravenously, up to 20 infusions with the transition to a tablet form, 2 tab. 3 times / day (1200 mg / day). The total duration of treatment is 6 months.
• With dementia - 2000 mg / day intravenously. The duration of treatment is up to 4 weeks.
• In case of peripheral circulation disorders and their consequences - 800-2000 mg / day intravenously or intravenously. The duration of treatment is up to 4 weeks.
• In case of diabetic polyneuropathy - 2000 mg / day intravenously, 20 infusions with the transition to a tablet form, 3 tab. 3 times / day (1800 mg / day). The duration of treatment is from 4 to 5 months.

Instructions for use of ampoules with a break point

1. Position the tip of the ampoule point up.
2. Gently tapping with your finger and shaking the ampoule, allow the solution to flow down from the tip of the ampoule.
3. Holding the ampoule in one hand with the tip up, with the other hand break off the tip of the ampoule at the break point.

Side effects

As practice shows, the drug is well accepted by patients and does not cause side effects. But, nevertheless, in rare cases, anaphylactic and allergic reactions associated with individual intolerance to the drug may occur. In addition, the following side effects sometimes appear when taking Actovegin:

• slight redness of the skin or;
• general malaise;
• nausea and vomiting;
• headache and loss of consciousness;
• disruption of the gastrointestinal tract;
• joint pain;
• difficulty breathing, sometimes choking caused by stiffness respiratory tract;
• increased sweating;
• stagnation of water in the body;
• due to the stiffness of the airways, the patient may even have problems swallowing water, food and saliva;
• excessive excitement and activity.

special instructions

1. Solution for injection and infusion solutions have a slightly yellowish tint. The color intensity may vary from one batch to another, which does not affect the effectiveness of the drug. Do not use an opaque solution or a solution containing particles.
2. When administered intramuscularly, Actovegin should be administered slowly, no more than 5 ml.
3. Due to the likelihood of an anaphylactic reaction, a trial injection (2 ml intramuscularly) is recommended.
4. The solution of Actovegin in the opened package is not subject to storage.
5. With repeated injections, it is necessary to control the water and electrolyte balance of the blood plasma.

The use of the drug Actovegin intravenously is indicated to protect the organs and systems of the body from damage due to insufficient blood supply and oxygen starvation, as well as to improve the functioning of intracellular enzyme systems.

Forms of release of the drug

Actovegin for intravenous administration is available as a ready-made solution for infusion. It is packaged in 250 ml bottles. There are 2 dosages of this form of release:

• containing 4 mg of deproteinized hemoderivate from calf blood in 1 ml of the product;
• with a content of 8 mg of the active ingredient in 1 ml of the product.

As a solvent in these products, dextrose or 0.9% sodium chloride solution can be used.

In addition, Actovegin is produced in ampoules containing 2, 5 and 10 ml of a solution, each milliliter of which contains 40 mg of deproteinized hemoderivate from calf blood. Thus, 1 ampoule contains 80, 200 or 400 mg of the active ingredient. This form of release of the drug is also used for intravenous administration.

There is Actovegin in the form of tablets, cream, ointment and gel. But they are intended for internal or external use, and not for intravenous administration.

Indications

The use of the drug Actovegin intravenously is indicated for:

• violations of cerebral blood flow;
• ischemic strokes;
• metabolic disorders;
• craniocerebral injuries;
• diabetic polyneuropathy;
• burns of thermal and chemical origin;
• frostbite;
• pathologies of peripheral vessels;
• damage to the skin and mucous membranes resulting from exposure to radiation or radiation therapy.

In addition, athletes use Actovegin to increase endurance and accelerate the healing of injuries. Also, the drug can be used intravenously for other conditions at the discretion of the doctor.

Solution preparation

If Actovegin is injected into a vein by jet, that is, directly from a syringe, then a solution from ampoules is used that does not require preparation.

If there is a drip injection of the drug using the so-called "dropper", then dilution of the ampoules will be required.

Instructions on how to dilute Actovegin intravenously:

• In the form of a basic solution, 0.9% sodium chloride solution or 5% glucose solution is used;
• Depending on the doctor's prescription, ml of Actovegin is added to the vial containing ml of the stock solution;
• Actovegin prepared in this way can be injected into a vein using a system (“dropper”).

Important! The product does not contain a preservative, so open ampoules and the prepared solution should be used immediately.

It is forbidden to mix Actovegin in one vial with other medicines, except for those indicated above.

Intravenous administration

Actovegin is administered intravenously by drip or jet. It is very important that all manipulations are carried out under sterile conditions. It is forbidden to use a cloudy solution, with signs of sediment. The contents of the ampoule should be transparent, from colorless to light yellow.

Due to the possible development of anaphylactic reactions when using the drug, it is recommended to first check for sensitivity to the drug before intravenous administration.

The preparatory stage of administering the drug into a vein in any way is the same:

• Before the procedure, you need to prepare everything necessary materials and medicines;
• Immediately before manipulation, you need to wash your hands and treat them with an antiseptic.

Instructions on how to administer Actovegin intravenously drip:

• First prepare the system and the injected solution;
• If a ready-made solution for infusion is used, then it can be administered immediately. Otherwise, Actovegin is diluted with the solution indicated by the doctor;
• The patient is laid horizontally and a tourniquet is applied 5 cm above the venipuncture. After that, they are asked to squeeze and unclench their fist several times to fill the vein;
• The puncture site is wiped with alcohol and the needle is inserted into the vein 1/3 of the length (before that, you need to release a few drops of the solution to make sure there is no air in the system);
• After the appearance of blood in the tube, open the clamp on the system, remove the tourniquet and fix the needle with adhesive tape;
• Regulate the rate of drug administration and monitor its constancy. Intravenous drip administration of Actovegin should be carried out at a rate of 2 ml per minute;
• Stop the infusion at the moment when there is still some liquid left in the vial. This is necessary to prevent air from entering the vein;
• During the procedure, you need to monitor the place where the needle is inserted. If swelling of the tissues appears, it is necessary to interrupt the intravenous administration and resume it in another vein using a new sterile needle.

If the infusion of the drug will be carried out for several days in a row, then the use of special intravenous catheters is recommended, which eliminates the need for a daily puncture of the vein.

Intravenous drip administration of Actovegin should only be carried out by medical professionals.

Jet Actovegin is administered intravenously undiluted:

• After preparatory phase, the patient is laid horizontally or seated;
• The required amount of medicine is drawn into a syringe;
• A tourniquet is placed on the patient's arm. They ask the person to work with his fist to fill the vein with blood;
• The injection site of the needle and the elbow area are treated with a cotton or napkin moistened with alcohol;
• A needle is inserted into the vein 1/3 of the length, the tourniquet is removed and the drug is injected;
• After the injection, a cotton swab moistened with alcohol is applied to the injection site, and the patient is asked to bend his arm at the elbow until the bleeding stops.

According to patient reviews, pain and discomfort are noted with this administration of the drug. Therefore, it is better to choose the infusion administration of the drug into the body.

Intra-arterial administration

Separately, the intra-arterial method of using the drug, which involves the introduction directly into the artery, should be considered. This method is used for violations of arterial circulation. Usually the injection is carried out in the radial or tibial artery. But since the technique for performing such an introduction is very complicated, it is used quite rarely.

Applied doses of medication

The dose of the drug is selected by the doctor in each case individually, taking into account the presence of indications, the patient's condition, the characteristics of the body and susceptibility to treatment. Actovegin injections intravenously can be administered in the following doses:

• From 20 to 50 ml of Actovegin, together with a solution of sodium chloride or glucose, every day in the first week of treatment for ischemic stroke. From the second week, the dose is reduced by a dose of medication per day. A ready-made infusion solution can be used per ml per day;
• From 5 to 25 ml of the drug or 250 ml of solution for intravenous infusion for cerebrovascular and metabolic disorders;
• To accelerate the healing of wounds, a daily administration of 10 ml of the drug is usually used;
• In case of violations of peripheral blood flow, the recommended dose is from 20 to 30 ml of the drug or 1 bottle of infusion solution daily;
• For preventive purposes, when receiving radiation therapy, an infusion of 1 vial of the solution is prescribed daily. Intravenous administration start 1 day before the start of therapy and continue for another 14 days after;
• 50 ml of the drug is required to be administered for diabetic polyneuropathy daily for 3 weeks;
• In other severe cases, a ml of the drug is used for 1 infusion, in lighter cases - from 5 to 20 ml. Accordingly, at severe course diseases, 2 bottles (500 ml) of a ready-made solution for infusions are used, and with a lighter one, 1 bottle (250 ml) of such a solution is enough.

When the use of the drug is prohibited

Actovegin has a high degree safety, but it has some contraindications. It:

• intolerance to the components of the drug;
• pulmonary edema;
• violations of the excretion of fluid from the body;
• hypernatremia;
• anuria;
• oliguria;
• heart failure in the phase of decompensation;
• hyperchloremia.

Unwanted Effects

Actovegin injections are well tolerated by patients. Occasionally, redness and irritation may appear at the injection site.

Speaking of systemic adverse reactions on the body, the medicine can cause:

• allergic reactions, up to angioedema;
• dizziness;
• swelling;
• difficulty breathing;
• chest pain;
• drop or rise in blood pressure;
• pain in muscles and joints.

Other undesirable effects may occur, a complete list of which can be found in the package insert for Actovegin.

Use in special groups of patients

According to the instructions for use, Actovegin is not recommended for the treatment of children, since there have been no clinical researches confirming this use. However, more and more drugs are prescribed for various violations blood flow in children, the consequences of hypoxia, brain injuries and various neurological problems.

Women during pregnancy, the remedy is also prescribed. It is used to improve placental blood flow, reduce hypoxia, with the threat of premature birth, detachment of the fetal egg.

Found an error? Select it and press Ctrl + Enter

IMPORTANT. The information on the site is provided for reference purposes only. Do not self-medicate. At the first sign of disease, consult a doctor.

Actovegin - instructions for use (injections, tablets, ointment, gel, cream). Why is Actovegin prescribed?

Varieties, names, composition and forms of release

Actovegin is currently available in the following dosage forms (which are also sometimes called varieties):

• Gel for external use;
• Ointment for external use;
• Cream for external use;
• Solution for infusions ("droppers") on dextrose in 250 ml bottles;
• Solution for infusion in 0.9% sodium chloride (in saline) in 250 ml bottles;
• Solution for injection in ampoules of 2 ml, 5 ml and 10 ml;
• Tablets for oral administration.

Gel, cream, ointment and Actovegin tablets do not have any other everyday simplified name. But forms for injection in everyday life are often called simplified names. So, the injection solution is often called "Actovegin ampoules", "Actovegin injections", as well as "Actovegin 5", "Actovegin 10". In the names "Actovegin 5" and "Actovegin 10" the numbers mean the number of milliliters in an ampoule with a solution ready for administration.

• Gel Actovegin - contains 20 ml of gemoderivate (0.8 g in dried form) in 100 ml of gel, which corresponds to 20% concentration of the active ingredient.
• Ointment and cream Actovegin - contain 5 ml of gemoderivate (0.2 g in dried form) in 100 ml of ointment or cream, which corresponds to 5% concentration of the active ingredient.
• Solution for infusion in dextrose - contains 25 ml of hemoderivate (1 g in dried form) per 250 ml of a ready-to-use solution, which corresponds to an active ingredient concentration of 4 mg / ml or 10%.
• Solution for infusion in 0.9% sodium chloride - contains 25 ml (1 g dried) or 50 ml (2 g dried) hemoderivat per 250 ml ready-to-use solution, which corresponds to an active ingredient concentration of 4 mg / ml ( 10%) or 8 mg/ml (20%).
• Solution for injection - contains 40 mg of dry hemoderivat per 1 ml (40 mg / ml). The solution is available in ampoules of 2 ml, 5 ml and 10 ml. Accordingly, ampoules with 2 ml of solution contain 80 mg of the active ingredient, with 5 ml of solution - 200 mg and with 10 ml of solution - 400 mg.
• Tablets for oral administration - contain 200 mg of dry hemoderivate.

All dosage forms of Actovegin (ointment, cream, gel, solutions for infusions, solutions for injections and tablets) are ready to use and do not require any preparation before use. This means that the ointment, gel or cream can be applied immediately after opening the package, the tablets can be taken without preparation. Solutions for infusion are administered intravenously (“dropper”) without prior dilution and preparation, simply by placing a bottle in the system. And injection solutions are also administered intramuscularly, intravenously or intra-arterially without preliminary dilution, simply by choosing an ampoule with the required amount of milliliters.

• Mountain wax glycolate;
• Titanium dioxide;
• Diethyl phthalate;
• Dried gum arabic;
• Macrogol 6000;
• Microcrystalline cellulose;
• Povidone K90 and K30;
• Sucrose;
• magnesium stearate;
• Talc;
• Dye quinoline yellow varnish aluminum (E104);
• Hypromellose phthalate.

The composition of the auxiliary components of the gel, ointment and cream Actovegin is shown in the table below:

Cream, ointment and gel Actovegin are available in aluminum tubes of 20 g, 30 g, 50 g and 100 g. The cream and ointment are a homogeneous white mass. Gel Actovegin is a transparent yellowish or colorless homogeneous mass.

The volume of Actovegin ampoules in ml

Actovegin solution in ampoules is intended for intravenous, intra-arterial and intramuscular injections. The solution in ampoules is ready for use, so to make an injection, you just need to open the ampoule and draw the medicine into the syringe.

Therapeutic action

Actovegin is a universal stimulant of metabolism, which leads to a significant improvement in tissue nutrition and the utilization of glucose from the blood for the needs of the cells of all organs. In addition, Actovegin increases the resistance of cells of all organs and tissues to hypoxia, as a result of which, even under conditions of oxygen starvation, damage to cellular structures is minimally expressed. The general, total effect of Actovegin is to increase the production of energy molecules (ATP) necessary for the flow of all vital processes in the cells of any organ.

• The healing of any tissue damage (wounds, incisions, cuts, abrasions, burns, ulcers, etc.) and the restoration of their normal structure are accelerated. That is, under the action of Actovegin, any wounds heal easier and faster, and the scar is formed small and inconspicuous.
• The process of tissue respiration is activated, which leads to a more complete and rational use of oxygen delivered with blood to the cells of all organs and tissues. Due to a more complete use of oxygen, the negative consequences of insufficient blood supply to tissues are reduced.
• The process of using glucose by cells that are in a state of oxygen starvation or metabolic depletion is stimulated. And this means that on the one hand, the concentration of glucose in the blood decreases, and on the other hand, tissue hypoxia decreases due to the active use of glucose for tissue respiration.
• Improves the synthesis of collagen fibers.
• The process of cell division is stimulated with their subsequent migration to areas where it is necessary to restore the integrity of the tissue.
• The growth of blood vessels is stimulated, which leads to an improvement in the blood supply to tissues.

The effect of Actovegin on enhancing glucose utilization is very important for the brain, since its structures need this substance more than all other organs and tissues of the human body. After all, the brain uses mostly glucose for energy production. Actovegin also contains inositol phosphate-oligosaccharides, the effect of which is similar to that of insulin. And this means that under the action of Actovegin, the transportation of glucose to the tissues of the brain and other organs improves, and then this substance is quickly captured by cells and utilized for energy production. Thus, Actovegin improves energy metabolism in the structures of the brain and provides its needs for glucose, thereby normalizing the work of all parts of the central nervous system and reducing the severity of cerebral insufficiency syndrome (dementia).

Indications for use (Why is Actovegin prescribed?)

Various dosage forms of Actovegin are indicated for use in various diseases, therefore, in order to avoid confusion, we will consider them separately.

• Acceleration of wound healing and inflammatory processes on the skin and mucous membranes (abrasions, cuts, scratches, burns, cracks);
• Improving tissue repair after burns of any origin (hot water, steam, solar, etc.);
• Treatment of weeping skin ulcers of any origin (including varicose ulcers);
• Prevention and treatment of reactions to the effects of radiation exposure (including radiation therapy of tumors) from the skin and mucous membranes;
• Prevention and treatment of bedsores (only for Actovegin ointment and cream);
• For preliminary treatment of wound surfaces before skin grafting in the treatment of extensive and severe burns (only for Actovegin gel).

Solutions for infusions and solution for injections (shots) Actovegin - indications for use. Solutions for infusions ("droppers") and solutions for injections are indicated for use in the same following cases:

• Treatment of metabolic and vascular disorders of the brain (for example, ischemic stroke, the consequences of a traumatic brain injury, impaired blood flow in brain structures, as well as dementia and impaired memory, attention, ability to analyze due to vascular diseases of the central nervous system, etc.);
• Treatment of peripheral vascular disorders, as well as their consequences and complications (for example, trophic ulcers, angiopathy, endarteritis, etc.);
• Treatment of diabetic polyneuropathy;
• Healing of wounds of the skin and mucous membranes of any nature and origin (for example, abrasions, cuts, incisions, burns, bedsores, ulcers, etc.);
• Prevention and treatment of lesions of the skin and mucous membranes when exposed to radiation, including radiation therapy of malignant tumors;
• Treatment of thermal and chemical burns (only for injection solutions);

Actovegin tablets - indications for use. Tablets are indicated for use in the treatment of the following conditions or diseases:

• As part of the complex therapy of metabolic and vascular diseases of the brain (for example, cerebrovascular insufficiency, traumatic brain injury, as well as dementia due to vascular and metabolic disorders);
• Treatment of peripheral vascular disorders and their complications (trophic ulcers, angiopathy);
• Diabetic polyneuropathy;
• Hypoxia of organs and tissues of any origin (this indication is approved only in the Republic of Kazakhstan).

Instructions for use

Ointment, cream and gel Actovegin - instructions for use

Various dosage forms of Actovegin for external use (gel, cream and ointment) are used for the same conditions, but at different stages of these diseases. This is due to various auxiliary components that give different properties to the gel, ointment and cream. Therefore, gel, cream and ointment provide scarring of wounds at various stages of healing with different types of wound surfaces.

• If the wound is weeping with copious discharge, then the gel should be used until the wound surface dries. When the wound dries up, it is necessary to switch to the use of a cream or ointment.
• If the wound is moderately wet, the discharge is poor or moderate, then a cream should be used, and after the wound surface has completely dried, switch to the use of an ointment.
• If the wound is dry, without discharge, then an ointment should be applied.

Rules for the treatment of wounds with gel, cream and ointment Actovegin

Actovegin tablets - instructions for use (adults, children)

Tablets are intended for use in the same conditions and diseases as injectable solutions. However, the severity of the therapeutic effect with parenteral administration of Actovegin (injections and "droppers") is stronger than when taking the drug in tablet form. That is why many doctors recommend that you always start treatment with parenteral administration of Actovegin, followed by a switch to taking tablets as a fixative therapy. That is, at the first stage of therapy, in order to quickly achieve the most pronounced therapeutic effect, it is recommended to administer Actovegin parenterally (by injections or "droppers"), and then additionally drink the drug in tablets to consolidate the effect achieved by injections for a long period of time.

Actovegin injections - instructions for use

Dosages and general rules for the use of Actovegin solutions

• Take the ampoule in your hands so that the breaking point is directed upwards (as shown in Figure 1);
• Tap the glass with your finger and gently shake the ampoule so that the solution drains from the tip to the bottom;
• With the fingers of the second hand, break off the tip of the ampoule in the area of ​​the point by moving away from you (as shown in Figure 2).

Figure 2 - The correct break off of the tip of the ampoule to open it.

• Metabolic and vascular disorders of the brain (traumatic brain injury, cerebrovascular insufficiency) - 5-25 ml of the solution is administered daily for two weeks. After completing the course of injections of Actovegin, they switch to taking the drug in tablets in order to maintain and consolidate the achieved therapeutic effect. In addition, instead of switching to a maintenance pill, you can continue injecting Actovegin by injecting 5-10 ml of the solution intravenously 3-4 times a week for two weeks.
• Ischemic stroke - Actovegin is administered by infusion ("dropper"), adding 20 - 50 ml of solution from ampoules to 200 - 300 ml of saline or 5% dextrose solution. In this dosage, the drug is infused daily for a week. Then, in 200-300 ml of infusion solution (saline solution or 5% dextrose), add 10-20 ml of Actovegin solution from ampoules and inject at this dosage daily in the form of "droppers" for another two weeks. After completing the course of "droppers" with Actovegin, they switch to taking the drug in tablet form.
• Angiopathy (peripheral vascular disorders and their complications, for example, trophic ulcers) - Actovegin is administered by infusion ("dropper"), adding 20-30 ml of the solution from the ampoules to 200 ml of saline or 5% dextrose solution. In this dosage, intravenous infusion, the drug is administered daily for four weeks.
• Diabetic polyneuropathy - Actovegin is administered intravenously, 50 ml of a solution from ampoules, daily for three weeks. After completing the course of injections, they switch to taking Actovegin in the form of tablets for 4 to 5 months to maintain the achieved therapeutic effect.
• Healing of wounds, ulcers, burns and other wound injuries of the skin - a solution is injected from ampoules of 10 ml intravenously or 5 ml intramuscularly either daily or 3-4 times a week, depending on the rate of healing of the defect. In addition to injections, Actovegin can be used in the form of an ointment, cream or gel to accelerate wound healing.
• Prevention and treatment of radiation damage (during radiation therapy of tumors) of the skin and mucous membranes - Actovegin is injected with 5 ml of a solution from ampoules intravenously daily, in between radiation therapy sessions.
• Radiation cystitis - inject 10 ml of a solution from ampoules transurethral (through the urethra) daily. Actovegin in this case is used in combination with antibiotics.

Rules for the introduction of Actovegin intramuscularly

Actovegin solution for infusion - instructions for use

Solutions for infusion Actovegin are available in two varieties - in saline or dextrose solution. There is no fundamental difference between them, so you can use any version of the finished solution. Such solutions of Actovegin are available in 250 ml bottles in the form of a ready-to-use infusion (“dropper”). Solutions for infusion are administered intravenously by drip (“dropper”) or intra-arterially by jet (from a syringe, as intramuscularly). Drip injection into a vein should be carried out at a rate of 2 ml / min.

• Circulatory and metabolic disorders in the brain (traumatic brain injury, lack of blood supply to the brain, etc.) - 250-500 ml (1-2 bottles) are administered once a day, daily for 2-4 weeks. Further, if necessary, in order to consolidate the obtained therapeutic effect, they switch to taking Actovegin tablets, or continue to inject the solution intravenously, 250 ml (1 bottle) 2-3 times a week for another 2 weeks.
• Acute disorders of cerebral circulation (stroke, etc.) - 250 - 500 ml (1 - 2 bottles) are administered once a day, daily, or 3 - 4 times a week for 2 - 3 weeks. Further, if necessary, they switch to taking Actovegin tablets in order to consolidate the obtained therapeutic effect.
• Angiopathy (impaired peripheral circulation and its complications, for example, trophic ulcers) - 250 ml (1 vial) is administered once a day, daily, or 3-4 times a week for 3 weeks. Simultaneously with the "droppers" you can apply Actovegin externally in the form of an ointment, cream or gel.
• Diabetic polyneuropathy - 250 - 500 ml (1 - 2 bottles) are administered once a day, daily, or 3 - 4 times a week for 3 weeks. Next, be sure to switch to taking Actovegin tablets in order to consolidate the resulting therapeutic effect.
• Trophic and other ulcers, as well as long-term non-healing wounds of any origin - 250 ml (1 bottle) is administered once a day, daily, or 3-4 times a week, until the wound defect is completely healed. Simultaneously with infusion administration, Actovegin can be used topically in the form of a gel, cream or ointment to accelerate wound healing.
• Prevention and treatment of radiation damage (during radiation therapy of tumors) of the skin and mucous membranes - 250 ml (1 vial) is administered one day before the start, and then daily during the entire course of radiation therapy, and additionally for another two weeks after last irradiation session.

special instructions

With repeated intravenous, intramuscular or intra-arterial administration of Actovegin, the level of blood electrolytes (calcium, potassium, sodium, chlorine) and the percentage of water in the body (hematocrit) should be monitored.

Overdose

In the Russian official instructions for use, there are no indications of the possibility of overdose with any dosage forms of Actovegin. However, in the instructions approved by the Ministry of Health of Kazakhstan, there are indications that when using tablets and solutions of Actovegin, an overdose may occur, which is manifested by pain in the stomach or increased side effects. In such cases, it is recommended to cancel the use of the drug, perform a gastric lavage and carry out symptomatic therapy aimed at maintaining the normal functioning of vital organs and systems.

Influence on the ability to control mechanisms

No dosage form of Actovegin (ointment, cream, gel, tablets, solutions for injections and solutions for infusions) affects the ability to control mechanisms, therefore, against the background of the use of the drug in any form, a person can engage in any type of activity, including those requiring high speed of reactions and concentration of attention.

Interaction with other drugs

Forms of Actovegin for external use (gel, cream and ointment) do not interact with other drugs. Therefore, they can be used in combination with any other means both for oral administration (tablets, capsules) and for topical use (creams, ointments, etc.). Only if Actovegin is used in combination with other external agents (ointments, creams, lotions, etc.), a half-hour interval should be maintained between the applications of the two preparations, and not smeared immediately after each other.

How to make an intramuscular injection (in the buttock) - video

Read more:

Reviews

Leave feedback

You can add your comments and feedback to this article, subject to the Discussion Rules.

Actovegin intravenously

Actovigin refers to supportive drugs that are used to accelerate the recovery processes in cells. It is used for rehabilitation after burns and radiation therapy, in situations where it is necessary to urgently improve cellular metabolism. The greatest effect gives the use of the drug Actovegin intravenously. Parenterally medicinal properties hemoderivative blood of calves, freed from protein, is preserved in its original form.

Why is Actovegin prescribed intravenously?

The following forms of the drug are available for sale:

• dragee for oral use;
• gel for external use;
• eye gel for fast healing retina and cornea;
• solution for intravenous and intramuscular injections;
• solution for intravenous infusion.

With maintenance therapy and for prophylactic purposes, Actovegin is used orally, however, in the process of passing through the digestive tract, the drug loses its main advantage - speed. It is for this reason that it is more advisable to use Actovegin as injections, intravenously or intramuscularly. At the first administration, the dose of vml for one application is acceptable. Subsequently, the patient is transferred to droppers with a lower concentration of the active substance.

What is the best way to inject Actovegin intravenously?

With intramuscular injection, the hidden resources of the body are turned on, the effect of the drug comes on rather quickly, but is less pronounced than when injected into the network of blood vessels. Injections can be given both in the veins and in the arteries, without making any distinction. So that Actovegin, when administered intravenously, does not cause allergic reaction, an allergic test to the main active substance can be carried out. To do this, a few drops of the solution are applied to the scarified finger. It is important to remember that in oral form the drug rarely causes individual sensitivity, so if you have used Actovegin dragees before, it is still better to do sensitivity tests.

Drip Actovegin is administered intravenously in such situations:

• cerebrovascular accident, stroke;
• peripheral circulatory disorders, injuries, bedsores;
• trophic disorders, varicose veins;
• prevention and treatment of radiation injuries.

The solution for intravenous infusion has a reduced concentration of the active substance - 5-10 ml per 250 ml of solution. It is administered once or twice a day for 7-10 days. A solution for a dropper can be prepared independently, by the method of administering Actovegin for injection in ml of glucose solution or saline. At the same time, it is not recommended to combine it with other drugs.

Copying information is allowed only with a direct and indexed link to the source