Korglikon indications for use. Description of the drug korglikon, instructions for its use and possible side effects. Release form and packaging

If previously, it was mainly older people who encountered articular pathologies due to age-related changes, but today even young people are faced with ailments of the inflammatory nature of the musculoskeletal system and their unpleasant symptoms: painful sensations of varying intensity, swelling, and stiffness.

The complexity of the diseases lies in the fact that they are difficult to treat, or even not completely cured. That is, if the illness has made itself felt, all the patient can do to prevent complications from occurring is to take measures to maintain health, in particular the proper condition of the joints.

Of course, it is better to start therapy for degenerative and dystrophic joint pathologies immediately - after the first alarming symptoms appear. It is not recommended to delay treatment or put it off until later, since it will be very difficult to stop the process that has started.

There are many reasons why joint problems may occur. The occurrence of joint ailments can be caused by: genetic predisposition, inactive or overly active lifestyle, scoliosis, addictions, injuries.

Athletes are also at risk for unpleasant symptoms, as they often suffer from various types of injuries. To solve this problem, some use medications (tablets, ointments, injections) that have anti-inflammatory and analgesic effects, others use complex nutritional supplements. One of the most effective medicines, according to numerous positive reviews from patients, is Glucosamine Chondroitin.

Previously, athletes used corticosteroids and anti-inflammatory drugs to combat joint pain. IN severe cases had to solve the problem surgically. Today, nutritional supplements that have proven their effectiveness in practice are becoming increasingly popular. Similar products can be purchased both in pharmacies and in online stores, their prices are affordable. Moreover, supplements are not so harmful to the body and have fewer side effects compared to corticosteroid drugs.

Composition and form of production

The main purpose of Glucosamine Chondroitin is to saturate the body with vital and necessary substances responsible for the proper functioning of the spinal column and joints.

Glucosamine sulfate is a substance that is found in low concentrations in food. The source of its production is cartilage cells. Chondroitin is one of the important components cartilage tissue, ligaments that ensure their strength under loads. This substance is also a component synovial fluid joint

Glucosamine Chondroitin helps restore cartilage tissue, increase the level of intra-articular fluid, ensure joint mobility, and normalize calcium and phosphorus metabolism. This complex is intended for people over 50, athletes, people whose professional activity associated with intense physical activity and those who are overweight.

This medicine is produced in the form of ointments, gels, tablets, capsules, and solution for injections. The main active components of the supplement are glucosamine and chondroitin sulfate. In addition, as indicated in the instructions, the product is endowed with potassium, silicon, sodium, manganese, ascorbic acid, hyaluronic acid.

Pharmacokinetics and pharmacodynamics

After oral use of the drug, its components are absorbed into the gastrointestinal tract. The bioavailability of chondroitin is 13%, glucosamine is 25%. Maximum concentration the drug in the blood is observed three to four hours after administration. Metabolism active ingredients occurs in the liver. The half-life of the drug's breakdown products, produced through the urinary system and gastrointestinal tract, occurs after 68 hours (glucosamine), 24 hours (chondroitin).

Action

The occurrence of joint ailments is often caused by the destruction of cartilage. The active components of the drug are components of cartilage. Due to joint damage, cartilage cells simply stop producing glucosamine.

The therapeutic effect of the drug is to provide building materials that are used for the formation of cartilage tissue and are a kind of protective pad for joints.

The use of Glucosamine Chondroxide promotes:

prevent friction and damage bone tissue;
improving collagen synthesis;
accelerating the regeneration of restoration processes in the musculoskeletal system;
elimination of the inflammatory process and pain;
increasing the resistance of cartilage to chemical influences;
increasing joint mobility, minimizing swelling;
eliminating tension in joints;
increasing the protective properties of the body;
nourishing joints;
normalization of metabolism.

Glucosamine Chondroitin complex: who is indicated, contraindicated, side effects

If anti-inflammatory and pain-relieving medications provide relief general condition and the patient’s well-being, as well as the elimination of pain, discomfort, swelling and puffiness, then Glucosamine Chondroitin complex helps treat pathology, nourishing cartilage tissue with protective substances that prevent destruction and help cells recover in a short time.

Glucosamine Chondroitin complex is a very effective dietary supplement that will help regulate metabolic processes, eliminate joint pain and improve general condition and well-being.

Medicine in any form - tablets, capsules, ointments or injection solution is effective in combating such pathological conditions and ailments of the spinal column and joints of a degenerative or dystrophic nature:

injury to joints and bones;
spondylosis;
arthropathy;
osteoarthritis;

The supplement is also used for preventive purposes - to improve the condition and functioning of the musculoskeletal system and the skin.

The product is certainly effective and efficient. However, only the attending physician can prescribe its use. In addition, it should be understood that this remedy must be used as part of complex therapy. For the treatment of joint ailments, the use of chondroprotectors, non-steroidal drugs that help eliminate the inflammatory process, the use of massage and supportive physical procedures designed specifically to correct the condition of the spinal column are usually prescribed.

Although this product is a supplement, it belongs to medicines and along with indications for use, it also has contraindications. The use of Glucosamine Chondroitin Complex is not recommended for people with individual intolerance, as well as for women during pregnancy and breastfeeding. Children should not be treated with this product.

In addition, the drug is not prescribed to people suffering from:

phenylketonuria;
diabetes mellitus;
serious disruptions in the functioning of the urinary system and liver;
tendency to bleeding;
thrombophlebitis.

Only a qualified specialist can prescribe the drug, its dosage, frequency of administration and course duration, and only taking into account the individual characteristics of the body and the patient’s age. In addition, before you start taking the medicine, you should read the instructions and make sure there are no contraindications.

Are there any possible side effects?

As a rule, the drug is well tolerated by patients. Side effects when consuming Glucosamine Chondroitin Complex are rare. The occurrence of unpleasant symptoms may be due to abuse of the supplement (more than 3000 mg).

Inappropriate use of the product is fraught with:

malaise;
diarrhea;
dizziness;
skin rashes;
increased risk of diabetes;
soreness in the limbs;
periodic pain in the epigastric region;
swelling;
pain in the head;
tachycardia;
flatulence.

If such symptoms appear, you should refrain from further use of the product, rinse your stomach, take the sorbent, and then seek the help of a qualified specialist.

Glucosamine Chondroitin: instructions for use, overdose and interaction

The active supplement is intended for oral administration. For the drug Glucosamine Chondroitin, the instructions for use indicate that the tablet must be swallowed whole. The medicine is washed down with plenty of liquid.

The dosage, regimen and frequency of use of the medication are selected by the doctor. When using Glucosamine Chondroitin, the instructions for use indicate that optimal duration therapeutic course - a month. Three or four courses can be conducted per year.

The daily dose is 1500 mg. It should be divided into two or three doses. The use of the supplement can be combined with taking steroids and other anti-inflammatory medications.

The combined use of the drug with magnesium, potassium or other minerals has a beneficial effect on the condition and functioning of the musculoskeletal and joint systems.

As indicated in the annotation, the dose of the drug should be selected taking into account body weight. People weighing less than 50 kg are prescribed 1000 mg of glucosamine and 800 mg of chondroitin, 50-90 kg - 1200 mg of chondroitin and 1500 mg of glucosamine, more than 90 kg - 1600 mg of chondroitin and 2000 mg of glucosamine.

Interaction

Simultaneous use of Glucosamine Chondroitin, according to the instructions for use, with antibacterial medications of the tetracycline group is fraught with an increase in the level of absorption of the latter.

Complex use of dietary supplements with penicillin antibiotics is fraught with a decrease in their effectiveness.

Overdose

The drug is well tolerated and cases of overdose are practically not described.

Abuse of the drug, exceeding the dosage, as well as independent extension of the course of treatment with Glucosamine Chondroitin according to the instructions for use, is fraught with the appearance of:

pain in the epigastric region;
nausea and vomiting;
flatulence;
constipation;
diarrhea;
pre-fainting states;
headaches
drowsiness;
dermatitis;
redness of the dermis;
swelling;
rash;
increased fatigue;
sleep disorders.

If such symptoms occur, you must stop using the medication and mandatory Seek help from a qualified professional. In case of overdose, symptomatic therapy is usually carried out.

Chondroxide Glucosamine: conditions of sale, storage and special instructions

This remedy is effective and will help in the treatment of musculoskeletal pathologies. You can buy Chonroxide Glucosamine at any pharmacy. The drug is dispensed strictly according to the doctor's prescription. So that the medicine does not lose its properties ahead of time medicinal properties, it should be stored correctly - in a dark place at a temperature not lower than 15 and not higher than 25 degrees. Chondroxide Glucosamine should be kept out of the reach of children. The shelf life of the product is three years.

special instructions

If side effects occur during the therapeutic course, for example, stool disorders, the dosage of Glucosamine Chondroxide is reduced by half. If side effects appear even after reducing the dosage, the medicine is discontinued.

In order to strengthen therapeutic effect Experts recommend enriching your diet with products rich in collagen, chondroitin, glucosamine: beef, chicken and sea fish. During the course it is worth limiting the consumption of sugar and liquids.

The product should not be given to children under 15 years of age. It is prohibited to drink alcohol while taking Glucosamine Chondroxide. Failure to comply with this recommendation is fraught not only with a decrease in the effectiveness of the drug, but with the development of side effects.

Glucosamine Chondroitin: analogues, cost and reviews of use

You can buy the supplement at any pharmacy or specialized online store. Glucosamine Chondroitin, analogues of which are also not expensive ( Russian production) on average - 4000 rubles. average cost medicines from a foreign manufacturer - 2000 rubles.

Analogs

The drug Glucosamine Chondroitin analogues, as well as the dietary supplement itself, can only be prescribed by a qualified specialist.

Often the product is replaced:

Artron Complex;
Chondroflex;
Ostealem.

Use during pregnancy and breastfeeding

The use of Glucosamine Chondroitin and its analogues is not prescribed during pregnancy and breastfeeding. The use of the drug can adversely affect the condition and formation of the fetus and the health of the newborn. If there are serious medical indications Before taking Glucosamine Chondroitin complex or its analogue, breastfeeding should be stopped for a while.

For children

The product is not prescribed for use by children under 15 years of age.

Formula: C6H13NO5 + n, chemical name: 2-Amino-2-deoxy-beta-D-glucopyranose + Chondroitin-4-(hydrogen sulfate) (as sodium salt).
Pharmacological group: correctors of cartilage and bone tissue metabolism in combinations.
Pharmachologic effect: anti-inflammatory, chondroprotective, stimulating the regeneration of cartilage tissue, analgesic, chondrostimulating.

Pharmacological properties

Stimulates the restoration of cartilage tissue. Chondroitin sulfate and glucosamine are involved in the formation connective tissue, help prevent cartilage destruction. The use of exogenous glucosamine stimulates the formation of cartilage matrix and protects cartilage from chemical damage. Glucosamine, as a sulfate salt, is a precursor to hexosamine, and the sulfate anion is needed for the production of glycosaminoglycans. Another possible property of glucosamine is protection against the metabolic destruction of damaged cartilage that is caused by glucocorticosteroids and non-steroidal anti-inflammatory drugs, as well as the presence of its own moderate anti-inflammatory effect. Chondroitin sulfate is an additional substrate for the synthesis of healthy cartilage matrix, whether it is supplied to the body as separate components or as an intact form. Enhances the synthesis of proteoglycans, hyaluronon and collagen type 2, protects hyaluronon from breakdown by enzymes (the activity of the hyaluronidase enzyme is suppressed) and from negative impact free radicals; maintains the viscosity of the joint fluid, enhances cartilage repair and reduces the activity of enzymes involved in the breakdown of cartilage (hyaluronidase, elastase). During the treatment of osteoarthritis, it reduces the manifestation of the disease and also reduces the need for taking non-steroidal anti-inflammatory drugs. The bioavailability of glucosamine when taken orally is 25% (due to first-pass effects through the liver). Distributed in tissues: maximum concentrations are found in articular cartilage, kidneys and liver. Approximately 30% of the dose taken persists for a long time in muscle and bone tissue. It is mainly excreted unchanged in urine, a little in feces. The half-life is 68 hours. When taken orally 0.8 grams (or 0.4 grams 2 times a day), the content of chondroitin sulfate in plasma increases during the day. Absolute bioavailability is 12%. About 20 and 10% of the dose taken are absorbed as low molecular weight and high molecular weight derivatives, respectively. The apparent volume of distribution is approximately 0.44 ml/g. During desulfurization processes it is metabolized. Excreted in urine. The half-life is 310 minutes.

Indications

Osteoarthritis grades 1–3.

Method of use of glucosamine + chondroitin sulfate and dose

The drug is taken orally 20 minutes before meals with a glass of water. Adults and children over 15 years of age: 2 – 3 times a day, 2 capsules (at the rate of glucosamine sulfate 250 mg + chondroitin sulfate 200 mg per capsule); The duration of therapy is 1–2 months; if necessary, the course of treatment can be repeated.
If you miss the next dose of the drug, take it as you remember, then take it after the time specified by the doctor from the last use. If undesirable effects from the digestive system appear, the dose of the drug should be reduced by 2 times, and if there is no improvement, then the drug should be discontinued. If there are no clinical effects when taking 4 capsules per day for 4 weeks, then the diagnosis needs to be clarified.

Contraindications for use

Hypersensitivity, phenylketonuria.

Restrictions on use

No data.

Use during pregnancy and breastfeeding

The use of the drug is contraindicated during breastfeeding and pregnancy.

Side effects of glucosamine + chondroitin sulfate

Glucosamine: disruption of the digestive system (epigastric pain, diarrhea, flatulence, constipation), skin allergic reactions, headache, peripheral edema, leg pain, dizziness, insomnia, drowsiness, tachycardia. Chondroitin sulfate: allergic reactions.

Interaction of glucosamine + chondroitin sulfate with other substances

Increases the absorption of tetracyclines, reduces the effects of semisynthetic penicillins. Compatible with glucocorticosteroids and non-steroidal anti-inflammatory drugs.

Overdose

Cases of overdose are unknown. If this occurs, it is necessary to rinse the stomach and carry out symptomatic treatment.

Trade names of drugs with the active ingredient glucosamine + chondroitin sulfate

Part of the complexes Glucosamine + Ibuprofen + Chondroitin sulfate, Glucosamine + Chondroitin sulfate + Vitamin E

People who begin to engage in active sports at some point inevitably have a question: how can they strengthen their joints and ligaments? High load on the musculoskeletal system during sports activities, one way or another, leads to the need to use additional drugs.

- Products for diet when playing sports
Vitamins for joints and ligaments of athletes
- Biological supplements
- Hodroprotectors
- Useful events
Which doctor should I contact for problems with ligaments and joints?

That's why doctors advise proper nutrition, as well as additionally use biological additives, vitamins, folk and medications to increase the elasticity and strength of the musculoskeletal system. Both foods in the diet and the drugs used tend to accumulate in the body. Therefore, it is necessary to dose the loads, gradually increasing their strength and frequency, along with the use of below listed drugs to avoid injury.

Do not forget that any drug used has side effects, so the use should be agreed with your doctor.

Proper nutrition to strengthen joints and ligaments

Preparing tendons, muscles, joints and ligaments for high loads requires changing your diet and diet. The amount of substances will depend on the lifestyle energy reserves, for the construction of muscle tissue, products that provide elasticity and strength to the fibers.

There are some rules for eating food that increase the efficiency of its processing by the body:

The above rules can help prepare an athlete for physical activity without much effort.

Products for diet when playing sports

Proper consumption of food is an important component for preparing the body, but the most important thing is to eat rational foods that help strengthen ligaments and joints.

Doctors have developed a complex of vitamins and microelements responsible for metabolic processes in the tissues of the musculoskeletal system. To prepare the body, it is necessary to enrich the diet with the following products:

To strengthen joint tissue the best products are those that have hyaluronic acid. They are:

Shrimps.
Agar-agar.
Kiseli.
Rich broth and fish soup.

Adding these products to the menu will certainly strengthen the ligaments and joints, allowing the musculoskeletal system to withstand increased loads when playing sports.

Vitamins for joints and ligaments of athletes

You need to follow nutritional rules and consume a certain set of foods during the entire active period. sports activities. But for any athlete, as well as people recovering from injuries, an additional source is required useful elements, namely vitamins.

First you need to determine what microelements and vitamins the body requires to strengthen ligaments and joints:

When choosing a complex of vitamins to strengthen joints and tendons, you need to pay attention to the amount of the above microelements. Examples of proper vitamins are:

Calcemin.
SustaNorm.
ArtriVit.
Orthomol Artro Plus.
Collagen Ultra.

These drugs have contraindications. You should consult your doctor about possible side effects and dosage instructions.

Medicines for joints and tendons

Usually, changing the daily menu and adding vitamins is not enough to achieve the required effect of strengthening the musculoskeletal system in athletes. IN in this case Chondroprotective agents and dietary supplements can help.

Before using these medications, you should consult your doctor.

Biological supplements

Dietary supplements are complexes of substances that are used together with food. They are not considered medications and do not require a prescription from a doctor. You need to be careful with these additives and not use them without preliminary consultation with a doctor.

Despite many controversies regarding the safety and effectiveness of these complexes, professional athletes speak positively about the use of dietary supplements.

Supplements for ligaments and joints contain natural substances. The main elements of supplements for strengthening the musculoskeletal system are chondroprotectors - these are natural substances that normalize metabolic and recovery processes, strengthening cartilage tissue.

Supplements for Tendons and Joints:

Do not forget to soberly assess the balance of harm and benefit from using supplements. Trust the choice of a specialist when choosing dietary supplements.

Hodroprotectors

Today on the market there is a fairly narrow range of medications that can help restore or strengthen damaged joints and ligaments. As a rule, the list of products is limited to the chondroprotectors described above.

Unlike dietary supplements, medicinal chondroprotectors have medical certification and have shown their therapeutic effectiveness. These ointments, tablets, injections and gels affect the cartilage of the joint and normalize metabolic processes in its structures.

The accumulation of the substance in the joint capsule makes it possible to instantly restore lost tissue in the event of microdamage or injury. There are drugs isolated from the bone tissue of calves, marine organisms. Products containing glucosamine, mucopolysaccharides, chondroitin or a combination of these elements.

The most effective and modern medications are considered to be for tendons and ligaments in combination with non-steroidal drugs that strengthen cartilage and also relieve the symptoms of inflammation during joint injuries. Examples of drugs:

Chondrolol.
Chondroxide.
Arthroparon.
Alflutop.
Teraflex.
Artron Flex.

The drugs are made in gels, ointments and tablets, as well as in the form of injections.

Do not forget that the results from chondroprotectors can only be achieved after 3 months of constant use of the tablets.

Folk remedies for strengthening ligaments and joints

Folk remedies can also help with the problem of strengthening ligaments and tendons. The use of natural ingredients and herbs can not only prepare tissues for upcoming stress, but also relieve tension after active exercise.

As during use medications, you need to consult your doctor to identify contraindications to the use of a particular prescription. Even natural materials have some side effects that must be taken into account during their use.

To restore damaged elements, strengthen the fiber structure, and increase elasticity, the following are used:

The above products increase microcirculation at the site of use and have an anti-inflammatory effect. The immunomodulatory effect helps prevent the development of diseases. The fibers contained in herbs strengthen cartilage and ligaments in joints.

Useful events

Medicines, nutritional supplements and proper nutrition do not allow a novice athlete to strain the musculoskeletal system to the limit. Do not forget that gradual and measured load is the basis for harmonious and proper development.

Always perform a full and long warm-up. There is no need to start intense training immediately after consuming strengthening agents; allow the body to absorb the above substances.

To improve and restore the condition of ligaments, muscles and joints, alternate active training with sessions of yoga and therapeutic exercises.

After significant exercise, after consulting a doctor, undergo a course of physiotherapy and massage, take hot bath. These activities will restore the body’s structure after exercise and relieve fatigue.

Which doctor should I contact for problems with ligaments and joints?

An arthrologist deals with this issue. If this doctor is not in your area, then first you need to consult with a therapist. He will be able to determine the reason for your problem so that he can then refer you to further treatment to the required doctor.

Joint pain may simply appear due to various reasons, for example, due to injuries, infectious diseases and other reasons. If discomfort occurs due to an injury, the therapist will refer you to a traumatologist. One way or another, there is no need to self-medicate and wait until the joints and ligaments strengthen themselves.

Which chondroprotectors to choose for the treatment of joints

The pathogenesis of most degenerative and dystrophic diseases of the joints and spine is based on the destruction of intra-articular cartilage tissue, the condition of which determines the stage of the disease and its symptoms. Modern medicine found a way therapeutic effects on intra-articular cartilage - these are chondroprotectors for joints.

These medications are designed to stop the progression of pathological changes and, if possible, repair damaged cartilage. It should immediately be noted that the effect of such treatment will only be observed if initial stage diseases, in advanced cases of arthrosis, even the best chondroprotectors (CP) will be ineffective, since there is nothing to restore in the joint (all cartilage tissue has already been destroyed).

Mechanism of action of chondroprotectors

To understand how these medications help with joint diseases, for which pathology they will be effective, and for which treatment will be ineffective, it is necessary to understand how human joints are structured and what the role of cartilage tissue is.

How are joint cartilages structured?

All articular surfaces of the bones that form the joint are covered with cartilage tissue. Intervertebral discs are also made of it. The surface of the cartilage is smooth and constantly moisturized due to a special intra-articular lubricant - synovial fluid. By the way, nutrition of cartilage tissue also occurs due to the diffusion of substances from this liquid, since cartilage does not have its own blood vessels.

The main function of cartilage is to ensure smooth movements in the joint, in which the cartilaginous surfaces of the bones slide against each other; this process is also facilitated by intra-articular lubrication.

Structure of cartilage tissue:

Cells (chondroblasts and chondrocytes). These are young and mature cells of cartilage tissue. They produce an intercellular substance, a matrix, which makes up the bulk of cartilage. There are much fewer cells here.
The intercellular substance of cartilage is characterized by high hydrophilic ability - it binds water molecules, which make up up to 80% of the matrix. The intercellular substance consists of collagen fibers and chondromucoid. It is the latter substance that is responsible for the integrity, strength, shape and function of the hyaline cartilage of the joint. It contains substances such as chondroitin and glucosamines (structural units of cartilage tissue).

The destruction of cartilage (regardless of the root cause) begins precisely with a decrease in the amount of glucosamines and chondroitin, which leads to the disintegration of cartilage tissue, the appearance of roughness on its surface, cracking and a decrease in the thickness of the cartilage. In connection with this or in parallel, the production of synovial fluid rich in hyaluronic acid decreases, which further aggravates the condition.

Movements in the joint become painful, the articular surfaces of the bones become exposed, which leads to the development of arthrosis and osteochondrosis with all the ensuing consequences.

Point of application for chondroprotectors

Chondroprotective drugs, when prescribed in a timely manner, can stop the destruction of cartilage tissue and, to some extent, even restore the damaged structure of the cartilage. The fact is that their composition is based on the aforementioned chondroitin and glucosamines, which, when entering the body, begin to “integrate” into damaged cartilage, thus restoring their structure and function.

Classification of chondroprotectors

Chondroprotectors can be divided according to three criteria:

by composition;
by generation of medicine;
according to the method of administration.

Types of chondroprotectors depending on composition

CPs that contain chondroitin sulfate (Chondroxid, Mucosat, Chondrolone, Chondroitin, Structum, Artron Chondrex, Chondroitin-phytopharm).
HP that contain glucosamine (Artron flex, Flexamine glucosamine, Dona).
Combined CP (chondroitin + glucosamine) – Artron complex, Teraflex, Chondroitin complex.
Combined CP (chondroitin and/or glucosamine + NSAIDs - ibuprofen, diclofenac) - Triactiv, Artron, Movex, Advance, Artrodar.
CP, which are an extension of cartilage and bone marrow animals (Alflutop, Rumalon).

Types of chondroprotectors depending on generation

The first generation is not purified extracts from animal cartilage and bone marrow. At this time, only Alflutop is used. It has a large number of allergic reactions.
The second generation is mono-preparations based on glucosamine or chondroitin, which are listed above.
The third generation is combination drugs.
Separately, it is worth highlighting hyaluronic acid for intra-articular injections (Ostenil, Fermatron, Sinokrom, Viskosil, Suplazin, Sinvisk).

Types of chondroprotectors depending on the method of administration

HP for oral administration (tablets, capsules) – Structum, Artra, Teraflex. They are well tolerated by patients and cause virtually no side effects. The effectiveness of oral forms is low, since most of the active substance is lost during metabolic changes.
CP in the form of injections (intramuscular and intraarticular) – Alflutop, Dona, all drugs hyaluronic acid. More often they cause allergic reactions and complications associated with the injection, but their effectiveness is much higher.
HP for external use (ointments, gels, creams) – Chondroxide. It is used only in complex treatment.

How to choose a drug?

Answering the question of how to choose a chondroprotector drug for the treatment of joints is not so simple. Firstly, the range of such medicines in modern pharmaceutical market big enough. Secondly, the price of such treatment is very high, and given the need for a long course, which can reach a year or a year and a half, for some patients the cost becomes prohibitive. Thirdly, the effect of treatment with chondroprotectors does not occur immediately (the first positive signs can be noticed after 3-4 months of regular use).

Considering all of the above, before purchasing these medications, you should definitely consult with your doctor, who will determine whether there is really a need for such therapy and which drug is most suitable in your case.

However, in order to somehow navigate the choice, it is necessary to evaluate chondroprotective drugs according to the following criteria.

Mono-drug or combined?

From the above classification of CP, it is clear that they can be single-component (mono-drugs) or combined. As a rule, the combination consists of two main substances - chondroitin and glucosamine; there are no others yet. Some drugs also contain a non-steroidal anti-inflammatory drug (Ibuprofen or Diclofenac).

It would seem that it is better to choose a medicine that contains both glucosamine and chondroitin, because both of these substances are equally important for the body. But in practice, there are some nuances to this choice: some sources of information claim that mono-drugs are more effective, while others talk about the benefits of combination drugs.

Why are there such different opinions? Firstly, chondroprotectors are “young” drugs (the experience of their use is about 10-15 years). Secondly, the interest of pharmaceutical companies producing chondroprotectors plays a big role. It is known that in order to bring one drug to market, billions of dollars are needed (the cost of clinical and other types of research, advertising campaign, etc.). Therefore, often the information obtained as a result of research sponsored by a certain company is not always true.

The recommendation is this: first of all, you need to address this question to a practicing arthrologist who, based on his experience in using these drugs and knowledge, will be able to advise a truly effective CP. Patient reviews of a particular drug will also provide excellent help.

Company manufacturer

This is a very important selection criterion, because a well-known and respected pharmaceutical concern all over the world can afford the most expensive and precise equipment, modern technologies manufacturing of drugs, a high degree of purification of drugs and real clinical studies of the effectiveness of drugs, in contrast to unknown factories.

By purchasing branded drugs rather than generics, you can be sure that for your money you will receive only high-quality medicine, which will minimize all side effects, allergic reactions and ineffective therapy.

Medicine or dietary supplement?

If a chondroprotector claims to be medical product, then there must be clinical studies that confirm its effectiveness, composition, indications, contraindications, side effects etc.

In case of biological active additive(dietary supplement) this is not at all necessary. But you must understand that then there can be no talk about the chemical purity of the drug, the amount of active substance that is in one tablet (and it may not be there at all), or the effectiveness of such treatment.

The instructions for the drug are your main “weapon” - be sure to read it before purchasing. It indicates whether the drug is a dietary supplement or a medicine.

Disease stage

As already mentioned, CPs are effective only in the initial stage of the disease (stages 1 and 2 of arthrosis, osteochondrosis). If your pathological process has already gone far (stages 3 and 4), then there is no longer any reason to take chondroprotectors, since the cartilage tissue is completely destroyed. But these medications are not able to restore it.

Indications and prohibitions for use

Indications for the use of chondroprotectors are:

deforming osteoarthritis stage 1-2 (including coxarthrosis, gonarthrosis);
spinal osteochondrosis in the initial stages;
prevention of joint degenerative diseases in people at risk (age after 50 years, athletes, people who have occupational hazards - severe physical labor or, conversely, long-term stay in one position, overweight people, after an injury, people with other diseases of the musculoskeletal system, with endocrinological and metabolic disorders).

Contraindications to the prescription of CP are individual intolerance to the components, pregnancy and lactation.

List of the most effective chondroprotectors

The following list of the most effective CPs was compiled taking into account patient reviews, recommendations of arthrologists, clinical research data and the reputation of the manufacturer:

Don. This is a mono-drug of glucosamine sulfate. It exists in the form of powder for oral administration and ampoules for intra-articular or intramuscular injections. Produces it medical medicine Rottapharm (Italy).
Artra. Chondroitin and glucosamine complex. These tablets are produced in the USA. It is highly effective at long-term use and safety.
Lifebox. A complex based on a third-generation chondroprotector with the addition of MSM, hyaluronic acid and type II collagen. Produced in Israel.
Teraflex. Complex HP, which is produced in the form of capsules and external cream by the American company Sagmel.
Structum. The drug chondroitin in capsules for oral administration is produced by the French pharmaceutical company Sotex.
Alflutop. This is HP in first generation ampoules. It is an extract of 4 species of Black Sea fish. Used for intra-articular and intramuscular injections. A common side effect is allergies.
Toad stone. This is a dietary supplement for plant based. There are capsules for internal use and ointment for external use.

To summarize, it can be noted that choosing HP is really difficult. Therefore, in order to get maximum effect from treatment and minimum side effects, this should be done by a specialist.

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Glucosamine Chondroitin complex is not inherently medicine, but is considered a dietary supplement that is taken with food consumed.

The main purpose of this complex is to enrich the human body with all the necessary elements that are responsible for the full functioning of the joints and spine.

Why is Glucosamine needed?

Glucosamine sulfate is a substance that is found in small quantities in food.

The source of its production in the human body is the cartilage cells of the body.

Due to this, the productivity of sugar chains, which are the main restorative components of cartilage tissue, is stimulated.

Initially, the substance was used by veterinarians to treat arthritis in animals.

Having convinced themselves of the safety of the remedy, they began to use it to treat people.

The drug became widespread in Europe in the 80s for the treatment of osteoarthritis and.

When taken, glucosamine had a rapid effect on connective tissue and articular cartilage. At the same time, the positive properties of the component for the human body were recorded.

Scientists at the Gustinia Hospital in Venice have revealed evidence of a decrease in common symptoms chronic osteoarthritis by 80% in three weeks. The effect was felt approximately 6-7 days after the first use of the product.

To be absolutely sure, the scientists took tissue samples from the patients' hips and knee cartilages for research.

After taking this drug, the surfaces of the patients' cartilage acquired an almost smooth coating, and the characteristics of osteoarthritis were very weak. From this it was concluded that the product has a restorative effect on the cartilage of the body.

Today the drug is used as a dietary supplement.

It is absorbed into circulatory system and intestines, then makes its way to blood vessels subchondral bone, from where it penetrates into the cartilage.

Chondroitins then begin to absorb glucosamine, which leads to full formation cartilaginous tissues.

Naturally, the amount of cartilage restored and formed depends on the amount of glucosamines.

Chondroitin is the basis of cartilage tissue

- This is one of the important connecting composite cartilaginous tissues and ligaments that provide strength during compression and tension. The formative component is cartilage tissue.

The component also performs the function of lubrication, being part of the joints. Dietary supplements with this drug are made from extracts of active substances from livestock, pigs and sharks.

Preparations made on the basis are used to normalize calcium-phosphorus metabolism and affect acceleration of cartilage restoration, increases the level of intra-articular fluids.

Thanks to a sufficient amount of this substance, joint mobility is ensured, while joint pain is reduced.

Considering that glucosamine and chondroitin have a complementary effect, today the pharmaceutical industry has produced a large number of drugs based on these substances.

Complex based on components: what joints need

The fundamental components of the complex have a fundamental role in the process of formation of cartilage tissue and support of the appropriate level.

Through the use of the complex, the process of restoration of cartilage and surfaces damaged under the influence of inflammatory and degenerative factors is stimulated.

The complex also ensures protection of cartilage from “wear and tear” in certain categories of people:

athletes;
people over 50;
representatives of professions whose activities involve heavy physical activity and overweight people.

The drug is available in the form of capsules, ointments and cream.

Based practical experience applications and patient reviews, the most effective is to take the complex in tablet form, since the drug is safely absorbed by the gastrointestinal tract with further penetration into the circulatory system and joints.

The use of ointments or creams is considered less effective because the drug does not penetrate the skin well.

Pharmacological effects

Joint diseases are most often caused by excessive destruction of cartilage tissue.

Glucosamine and Chondroitin are the main components of cartilage. In case of joint damage, cartilage cells stop synthesizing Glucosamine.

Based on this, therapeutic effect The drug is that it provides building raw materials, which are used to form cartilage and serve as a protective lining for joints. This in turn prevents friction and bone destruction.

Thus the complex provides:

Pharmacokinetics of the drug

The bioavailability of the drug is more than 25%. In this case, the most pronounced effect of primary passage occurs through the liver.

When distributed into tissue, the highest effects are reflected in the liver, kidneys and articular cartilage. More than 30% of the dose of the drug taken persists in bone and muscle tissue for a longer period.

The drug is excreted in the urine and partially in the feces.

Mechanism of action

Glucosamine acts as a stimulant general process for cartilage restoration. It also affects the metabolic process in cartilage tissues and thereby prevents their destruction.

In addition, the substance has an anti-inflammatory effect, relieves painful sensations, swelling and increased sensitivity joints. Restores hardened and damaged joints, which are the sources of pain.

Chondroitin stimulates cartilage tissue to actively absorb fluid. This is very important, since the liquid is a source nutrients and a softening component of cartilage tissue.

Chondroitins are also protectors of old cartilage from premature destruction and act as building materials, thereby creating new, healthy cartilage tissue.

Glucosamine Chondroitin complex, being combination drug, are used to stimulate the process of regeneration of cartilage tissue.

The mechanism of action of the drug is accordingly determined by the properties of its constituent components.

In what cases is the complex used?

Glucosamine Chondroitin complex is used for degenerative diseases of the spine and joints:

Prescribed for older people and children over 15 years old, 40 minutes before eating, 1 capsule 2 times a day. This rule is valid during the introductory 3 weeks.

Beyond three weeks, the dose should be reduced to 1 capsule per day for 6 months.

The minimum period for taking the drug is 2 months. The maximum effect is achieved after taking the drug for six months.

for the purpose of prevention and improvement of the musculoskeletal system and skin;
in rejuvenating procedures;
in the process of treating various types of fractures and injuries;
for various types;
at skin diseases, hypersensitivity and allergies.

When should you abandon the complex?

Undoubtedly, representing an excellent balance of two components, the drug successfully demonstrates its effectiveness against an impressive number of diseases.

thrombophlebitis;
tendency to bleed;
in case of obvious violation normal function kidneys and liver;
for diabetes mellitus;
phenylketonuria;
during pregnancy;
during breastfeeding.

How to take the product

The course of taking the complex is equal to a month. Up to 3-4 cycles of taking the drug can be carried out per year.

The daily dosage is 1500 mg, and is divided into 2-3 meals with food.

In general, the choice of dosage regimen does not affect the effectiveness of the drug.

In parallel, you can take steroids and other anti-inflammatory drugs.

Taking the drug can be combined with simultaneous therapy with supplements containing potassium, magnesium and other minerals that have a positive effect on the musculoskeletal and joint systems.

Individual approach to dosage

It is enough to follow the instructions for use that come with the Glucosamine Chondroitin complex.

These standards provide for different target audiences.

Weighing less than 50 kg. 1000 mg glucosamine and 800 mg chondroitin.
Weighing more than 50 kg. up to 90 kg. 1200 mg chondroitin and 1500 mg glucosamine.
Weighing more than 90 kg. 1600 mg chondroitin and 2000 mg glucosamine.

Dosage adjustments should be made based on the individual's body response.

A certain proportion of patients feel a clear improvement after a short period of time and, based on this, reduce the dose of the drug.

People who are overweight or taking diuretics need higher doses.

Established generally accepted standards: 1 capsule 3 times a day during meals, daily for 2-3 months.

To prevent negative consequences Exceeding the prescribed dose of the drug is strictly not recommended.

Possible side effects

Taking the drug in the permitted doses is not dangerous and does not cause negative effects.

If daily norm exceeds 3000 mg, the drug may cause:

constipation and diarrhea;
a significant increase in the risk of developing diabetes;
stomach upset;
skin rashes;
dizziness.

Forms of release and composition of the product

The drug is available in the form:

tablets;
capsules;
powder;
injections;
ointments and gel.

Manufacturers offer wide range drugs in capsule forms. The complex is available in jars that contain 180 capsules, exactly the amount required for one course.

One capsule contains:

glucosamine sulfate – 1500 ml;
chondroitin sulfate (from cattle cartilage) – 1200 mg;
hyaluronic acid – 25 mg;
vitamin C – 60 mg;
manganese – 6 mg;
sodium – 125 mg;
potassium – 270 mg;
complementary components: silicon, components of crustaceans, seafood.

Overdose

In the practice of using the drug, cases associated with overdose are practically not described.

In case of overdose, symptomatic treatment is provided.

An overdose may be accompanied by the following disorders:

gastrointestinal tract area: painful sensation in the epigastric abdomen, nausea, vomiting, flatulence, constipation and diarrhea;
region nervous system : headaches, drowsiness and insomnia, dizziness, general weakness and increased fatigue;
allergic reactions: swelling, rash, itching, erythema, dermatitis.

If any negative symptoms occur while taking the drug, you should immediately stop taking it and consult your doctor.

Additional instructions

There are no data on the effectiveness and safety of the drug in children under 15 years of age.

Alcohol consumption is completely excluded.

If the functions of the kidneys and kidneys are impaired, taking the drug is not recommended, since if the liver or kidneys are dysfunctional, the removal of the drug from the body will be impaired.

In case of pregnancy, the drug should be taken under the supervision of a physician.

Interaction with other drugs

When interacting with other drugs, the effectiveness of the drug increases, which enhances the process of absorption of tetracyclines into the gastrointestinal tract.

At the same time, the absorption of chloramphenicol and semisynthetic penicillins decreases.

The relevance of using painkillers is decreasing.

How does it work in practice?

How effective and popular Glucosamine Chondroitin Complex is among consumers and doctors can be found out from reviews.

Along with positive opinions, there are also negative opinions.

What is the attitude of doctors towards the product?

Many people hear complaints from their grandmothers and mothers about joint pain. My knees and back often hurt.

And now, due to various reasons, joint diseases are increasingly common among young people.

Therefore - proper nutrition, moderate loads, light sports (for example, swimming, gymnastics) as well as complexes with glucosamine and chondroitin sulfate are a source of healthy joints. Course of admission: 40 days every 6 months or according to another scheme that you can choose for yourself.

The opinion of the general practitioner Pavel

Prescribed a course of treatment using the Glucosamine Chondroitin complex to a patient with arthrosis of the knees.

According to the patient, there is real relief, a decrease in pain symptoms already in the second week, it disappeared. In general, the drug lives up to all the promises that appear on the insert!

Arthur (doctor)

Patients say

It helps me and my sister brilliantly, I ordered more.

Zlata

Great, but should only be used as directed by a doctor.

The drug really helps, my joints stop hurting. The complex has an anti-inflammatory and analgesic effect, nourishes joints, and promotes cartilage restoration.

Grace

I use glucosamine for pain in the elbow joint. I drink it for 10 days, then take a break for 10 days. I advise everyone to take this method.

Tatiana Surzh

The skin at the site of damage has completely recovered, and there are practically no wrinkles.

Elena

Effective, convenient packaging. Just magic remedy, which helped me get on my feet, in the literal sense of the word.

Fedor

Judging by the reviews, the Glucosamine Chondroitin complex largely met the expectations of patients.

Negative reviews are mainly associated with the high price of the complex and the rather long course of treatment, which affects the total cost of treatment.

We must pay attention to the fact that maximum effect achieved when using the product for at least 6 months.

Price

The price of Glucosamine Chondroitin complex varies depending on the manufacturer and country of origin:

The information has been prepared for general information purposes and cannot be used as a basis for self-medication.

The entire treatment procedure must be carried out under the supervision and control of a physician. Self-medication often leads to disastrous consequences.

Hello, my dears! Lovers of dachas, gardens and vegetable gardens will understand me. With the onset of warm days and until late autumn, amateurs like me “rest” only on the ground with a hoe or rake in their hands.

And everything would be fine, but the longer you weed the beds, the more your back and knees hurt. A neighbor in the country advised me to take the drug Glucosamine Chondroitin. It cannot be called a medicine; rather, it is a dietary supplement whose purpose is to nourish joints and bones.

I still can’t determine for sure whether this drug has any effect, but I’ve been taking it every day for the last two months. My back and knees don’t bother me, I just don’t know if the dietary supplements helped or if I stopped going to the dacha.

Description of the drug

A product that is a combination of substances that support healthy bones, cartilage, tendons, joints and ligaments. Protects the musculoskeletal system from damage and injury during intense training and promotes rapid recovery.

Glucosamine is a necessary building material for cartilage tissue. It is used by the body to form connective tissue of cartilage, ligaments, tendons, heart valves, synovial (joint) fluid, nails, hair. According to the results of clinical studies, glucosamine sulfate has the maximum biochemical absorption (about 90%).

The main property of chondroitin sulfate is to retain water in the cartilage in the form of water cushions, which creates good shock absorption and absorbs shock when walking.

Chondroitin sulfate has an anti-inflammatory and analgesic effect, reduces pain in the joints and spine, increases their flexibility and mobility. It also activates the fixation of sulfur during the synthesis of chondroitin-sulfuric acid, which in turn promotes the deposition of calcium in the bones.

Glucosamine and chondroitin are actively used for the treatment of various joint disorders that are associated with degenerative processes in cartilage tissues, age-related changes, illnesses and intense physical activity. Also, the complex of these substances has proven itself well as a general tonic for the health of the skin, cardiovascular and other body systems.

Main properties of glucosamine and chondroitin

With regular use, glucosamine chondroitin complex:

Reduces joint inflammation;
Relieves pain;
Slows down the destruction of cartilage and activates its restoration;
Prevents cancer;
Improves skin condition and has other properties.

Glucosamine Chondroitin helps restore cartilage tissue, increase the level of intra-articular fluid, ensure joint mobility, and normalize calcium and phosphorus metabolism. This complex is intended for people over 50, athletes, people whose professional activities involve intense physical activity and those who are overweight.

This medicine is produced in the form of ointments, gels, tablets, capsules, and solution for injections. In addition, as indicated in the instructions, the product is endowed with potassium, silicon, sodium, manganese, ascorbic acid, and hyaluronic acid.

After oral use of the drug, its components are absorbed into the gastrointestinal tract. Bioavailability of chondroitin - 13%, glucosamine - 25%. The maximum concentration of the drug in the blood is observed three to four hours after administration. Metabolism of active substances occurs in the liver.

The half-life of the drug's breakdown products, produced through the urinary system and gastrointestinal tract, occurs after 68 hours (glucosamine), 24 hours (chondroitin).

What is chondroitin

Chondroitin sulfate belongs to the class of glycosaminoglycans - the main components of connective tissue that create the structure of bones, joints and ligaments. Chondroitin sulfate is the most common glycosaminoglycan in the human body. It includes:

Cartilage tissue;
Skin;
Tendons and ligaments;
Synovial (intra-articular) fluid;
Vessels;
Perineuronal network surrounding nerve cells and regulating their work;
Corneas of the eye.

Chondroitin sulfate molecules are long chains that create a three-dimensional network in which water molecules accumulate. This structure gives the cartilage elasticity, since in this case the water acts as a shock absorber.

When the load on the fabric increases, the liquid is “squeezed out” onto the surface, creating an additional protective film, the thickness of which depends on the force of the impact. Thanks to this, there is no friction in the joints.

Except structural function, chondroitin sulfate also has other biological properties:

Stimulates the reproduction and growth of chondroblasts - the precursors of chondrocytes;
Suppresses premature death (apoptosis) of chondrocytes;
Stimulates the synthesis of collagen, the main structural protein of connective tissue;
Neutralizes enzymes that destroy connective tissue;
Participates in the transport of water, lipids and amino acids;
Normalizes the composition of synovial (joint) fluid.

Chondroitin is a biological polymer that acts as a flexible connective matrix between protein strands in cartilage. The substance is extracted from the tissues of salmon fish or created using special methods in laboratories. Chondroitin sulfates play an important role in the formation of cartilage. Cartilage is located between the joints (fingers, knees, hips) and helps a person move painlessly.

Research has demonstrated that with sufficient amounts of chondroitin sulfate in cells that produce proteoglycan (a component that forms the cartilage matrix), an accelerated healing process occurs. Numerous medical examinations of patients have confirmed that no side effects or health risks have been identified from the use of chondroitin supplements.

Chondroitin enhances the synthesis of hyaluronic acid, thereby strengthening cartilage and other connective tissue structures. It blocks the action of enzymes that destroy joint tissue. Under its influence, cathepsin, elastase, peptidase, interleukin-1 and some other aggressive substances that are formed during the breakdown of chondrocytes lose their destructive ability.

By correctly using chondroitin and understanding what it is needed for, you can reduce pain in the affected joints when walking. And during the rest period, it improves the shock-absorbing properties of cartilage tissue and enhances its regeneration. The participation of chondroitin in the process of sulfur fixation during the synthesis of chondroitin-sulfuric acid ensures improved calcium deposition in bone tissue.

An important feature of chondroitin, compared to glucosamine, is its ability to retain water inside cartilage. The resulting “water cushions” create excellent shock absorption and perfectly absorb shock, increasing the density of connective tissue. By the way, in a separate publication on our website the question of whether glucosamine hydrochloride or sulfate is better, the therapeutic properties of which vary somewhat.

What is glucosamine used for?

Glucosamine's chemical structure is a monosaccharide, a modified glucose molecule. He is a kind of " building material» for chondroitin sulfate and hyaluronic acid. In addition, glucosamine:

Stimulates the production of chondrocytes structural components cartilage;
Deactivates substances that provoke inflammation;
Suppresses the synthesis of enzymes that destroy cartilage tissue;
Has antioxidant properties;
Normalizes calcium metabolism in bone tissue.

Glucosamine - natural Chemical substance in the body, a connecting component of your tissues, ligaments and joints. It is divided into two types: hydrochloride and sulfate.

Glucosamine sulfate helps the body maintain healthy cartilage, the “rubbery” tissue (connective) that softens the friction of bone in joints. As we age, joint strength begins to be lost, leading to gradual joint destruction.

To treat sports injuries, he advises using dietary supplements with glucosamine, which, in addition to giving elasticity and flexibility to your joints, have a positive effect on other areas:

reduce intestinal inflammation;
treat rheumatoid arthritis;
reduce long-term lower back pain;
prevent venous insufficiency;
solve problems with the temporomandibular joint.

The tandem of glucosamine and chondroitin is widely used for the treatment and prevention of joint disease. They have an analgesic effect, so their use reduces pain, and this is an opportunity to improve the quality of life of people suffering from chronic diseases spine or joints.

A significant difference between chondroitin and glucosamine is that the first is more effective when used externally (ointments, creams, gels), and the second is more effective when taken orally.

Regardless of the form in which glucosamine chondroitin enters the body, like its analogues, serves as an additional substance for the formation of a healthy cartilage matrix and enhances the synthesis of proteoglycans, hyaluron and collagen.

Glucosamine is indicated for use not only to eliminate pathological processes in various connective tissues, with its help you can speed up the process of restoration of damaged tendons.

Cosmetology is another area of application of chondroitin and glucosamine. Here they belong to the conventional group of enteral cosmetic preparations. Dermatologists also came to the conclusion that the use of these drugs helps to increase the production of collagen and elastin, which allows you to restore elasticity and youth to the skin without the intervention of plastic surgeons.

Both products are safe and have no side effects on the body. They are easily digestible and do not cause allergies. Glucosamine and chondroitin can be used either separately or in combination with other drugs.

If anti-inflammatory and analgesic medications help alleviate the general condition and well-being of the patient, as well as eliminate pain, discomfort, swelling and swelling, then Glucosamine Chondroitin complex helps treat pathology, nourishing cartilage tissue with protective substances that prevent destruction and help cells recover in a short time.

pharmachologic effect

Chondroitin Complex is a drug that has a pronounced chondroprotective effect. The drug contains two active components - glucosamine hydrochloride and sodium chondroitin sulfate. The drug prevents degenerative changes in joint tissue, its active components take part in the synthesis of connective tissue, stimulate the synthesis of collagen, proteoglycans and hyaluron.

In addition, chondroitin sulfate inhibits the activity of hyaluronidase and reduces the breakdown of hyaluron. The drug regulates phosphorus-calcium metabolism. The use of the drug in complex therapy of degenerative-dystrophic diseases of the musculoskeletal system makes it possible to reduce the dose of non-narcotic analgesics.

Sodium chondroitin sulfate is involved in the construction of cartilage tissue, is able to reduce the activity of enzymes that destroy joint cartilage, and stimulates its regeneration. Sodium chondroitin sulfate early stages inflammatory processes can reduce its activity, slowing down degenerative changes in cartilage tissue.

Reduces severity pain syndrome, improves functional state joints, reduces the need for non-steroidal anti-inflammatory drugs for osteoarthritis of the hip and knee joints.

Glucosamine hydrochloride eliminates the deficiency of glycosamines in the body, has chondroprotective properties, and is involved in the biosynthesis of proteoglycans and hyaluronic acid. Glucosamine hydrochloride exhibits affinity for cartilage tissue, initiating the process of sulfur fixation during the biosynthesis of chondroitinsulfuric acid.

Selectively acting on articular cartilage, glucosamine hydrochloride is a specific substrate, a stimulator of the synthesis of proteoglycans and hyaluronic acid, suppresses the formation of enzymes and superoxide radicals that predetermine damage to cartilage tissue (phospholipases, collagenases), prevents the destructive effect of glucocorticoids on chondrocytes, disruption of glycosaminoglycan production, induced by non-steroidal anti-inflammatory drugs.

After oral administration the active components of the drug are well absorbed into gastrointestinal tract. The bioavailability of chondroitin sulfate is 13%, glucosamine – 25%. The peak concentration of chondroitin in the blood plasma is observed 3-4 hours after taking the drug.

The active components are metabolized in the liver. The half-life of glucosamine is about 68 hours, chondroitin sulfate sodium is completely eliminated from the body within 24 hours. The active components of the drug are excreted primarily by the kidneys; a small part of glucosamine hydrochloride is excreted by the intestines.

Features of the use of the drug

Glucosamine + Chondroitin is prescribed for the treatment of those patients diagnosed with degenerative diseases of the spine and joints. In particular, the drug is indicated for patients with osteoarthritis and osteochondrosis.

This remedy, as well as other drugs with similar active ingredients (Glucosamine-Chondroitin Plus, Glucosamine + Chondroitin + MSM, etc.) are also prescribed if necessary to provide an additional source of these substances.

Indications for use

The drug is prescribed for the purpose of prevention and additional auxiliary therapy of degenerative-dystrophic diseases of the joints, for the restoration of joints in people who have suffered sports injuries and fractures.

Capsules may also be included in sports nutrition. The drug Chondroitin Complex is used in complex therapy of degenerative-dystrophic diseases of the joints and spine:

glenohumeral periarthritis;
osteoarthritis;
osteocondritis of the spine;
fractures (to accelerate the formation of callus).

Contraindications

Although this product is a supplement, it belongs to medicines and, along with its indications for use, it also has contraindications. The drug Chondroitin Complex is contraindicated for:

individual hypersensitivity to glucosamine hydrochloride, sodium chondroitin sulfate, as well as auxiliary components (croscarmellose sodium, sodium starch glycolate, low molecular weight medical polyvinylpyrolidone, magnesium stearate, Aerosil);
thrombophlebitis;
bleeding tendency;
severe kidney/liver dysfunction;
diabetes mellitus;
phenylketonuria;
during pregnancy;
during breastfeeding.

The use of Glucosamine Chondroitin Complex is not recommended for people with individual intolerance, as well as for women during pregnancy and breastfeeding. The drug Chondroitin Complex is not used in pediatric practice.

Directions for use and dosage

The dosage, regimen and frequency of use of the medication are selected by the doctor. When using Glucosamine Chondroitin, the instructions for use indicate that the optimal duration of the therapeutic course is a month. You can conduct three or four courses per year.

The drug is intended for oral use. It is recommended to swallow the capsules whole, without chewing or crushing, with a drink sufficient quantity liquids. The drug is taken 30 minutes before meals. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient.

Adults and adolescents over the age of 15 years are usually prescribed 1 capsule of the drug 2 times a day. 3 weeks after the start of drug therapy, switch to a maintenance dose of 1 capsule of the drug 1 time per day.

The duration of treatment is usually at least 2 months. To achieve a sustainable therapeutic effect, it is recommended to take the drug for at least 6 months.

Daily dose - 1500 mg. It should be divided into two or three doses. The use of the supplement can be combined with taking steroids and other anti-inflammatory medications.

The combined use of the drug with magnesium, potassium or other minerals has a beneficial effect on the condition and functioning of the musculoskeletal and muscular systems.

As indicated in the annotation, the dose of the drug should be selected taking into account body weight. People weighing less than 50 kg are prescribed 1000 mg of glucosamine and 800 mg of chondroitin, 50–90 kg - 1200 mg of chondroitin and 1500 mg of glucosamine, more than 90 kg - 1600 mg of chondroitin and 2000 mg of glucosamine.

Patients receiving therapy with Chondroitin Complex are advised to refrain from drinking alcoholic beverages and also reduce the amount of sugar in the diet.

Side effects

When taking products whose active ingredients are glucosamine and chondroitin (Weider Glucosamine Chondroitin Plus MSM, Glucosamine Chondroitin MSM, Ultimate Nutrition Glucosamine Chondroitin MSM, etc.), the following undesirable effects may develop:

stool disorders;
periodic pain in the epigastric region;
flatulence;
dizziness, headache;
swelling;
pain in the limbs;
tachycardia;
allergic manifestations;
disruption of biological rhythms.

If such symptoms appear, you should refrain from further use of the product, rinse your stomach, take the sorbent, and then seek the help of a qualified specialist.

Glucosamine is considered a safe supplement. During the studies, subjects took it at a dosage of 1500 mg per day for three years.

Studies in which glucosamine was taken for more than twelve months indicate that glucosamine sulfate itself continues to long time have a positive effect on health and reduction of joint pain, but the effectiveness of glucosamine/chondroitin and other combination supplements is gradually decreasing.

Most glucosamine as a supplement ingredient is obtained from organic seafood components. Therefore, before starting consumption, it is recommended to make sure whether you are allergic to seafood. If this is a problem for you, don't worry - there are special glucosamine supplements from plant sources that are marketed as vegetarian.

In the early stages of glucosamine research, there was some concern that glucosamine might negatively impact insulin resistance. However, several newer studies have concluded that taking glucosamine has no effect on it.

Overdose

The drug is well tolerated and cases of overdose are practically not described. Abuse of the drug, exceeding the dosage, as well as independent extension of the course of treatment with Glucosamine Chondroitin according to the instructions for use, is fraught with the appearance of:

pain in the epigastric region;
nausea and vomiting;
flatulence;
constipation;
diarrhea;
pre-fainting states;
headaches;
drowsiness;
dermatitis;
redness of the dermis;
swelling;
rash;
increased fatigue;
sleep disorders.

If such symptoms occur, you must stop using the products and be sure to seek the help of a qualified specialist. In case of overdose, symptomatic therapy is usually carried out.

Special instructions for taking the drug

One of the most safe medicines considered “Glucosamine-Chondroitin” (complex). These capsules are easy to drink, they are easily absorbed and rarely cause side effects. But you still need to know the features of their use and combination with other medications:

if there is no improvement two weeks after starting treatment, you should consult your doctor about the possibility of replacing the drug with its analogues - “Arthra”, “Teraflex”, “Chondroflex” and others;
this drug impairs the absorption of penicillin antibiotics;
Tetracycline drugs begin to be absorbed more quickly and may cause side effects;
The complex combines well with non-steroidal anti-inflammatory drugs and glucocorticosteroids, enhancing their effect;
during treatment it is necessary to completely exclude alcoholic drinks, limit your sugar intake.

If side effects are observed during therapy, in particular, dysfunction digestive system, it is necessary to reduce the dose of the drug by half. If side effects persist, therapy should be discontinued.

For more pronounced effect During the treatment process, foods containing glucosamine, chondroitin, and collagen should be included in the diet. These are beef, chicken, sea fish, etc. Learn more about which products contain necessary for the body substance, a specialist will tell you.

Drug interactions

The Glucosamine-Chondroitin complex in combination with tetracyclines can lead to an increase in the absorption of the latter. When the drug interacts with lemomycetin and semisynthetic penicillins, on the contrary, their degree of absorption decreases.

This medication reduces the need for taking NSAIDs, corticosteroids and painkillers. Treatment with this drug becomes more effective when the patient’s diet includes foods with vitamins C and A, as well as salts of copper, manganese, selenium, zinc and magnesium.

Alternative forms of application

Modern medicine produces glucosamine hydrochloride in the form medicinal substance or dietary supplements, equating them to the group of chondroprotectors that better influence the metabolic functions of cartilage tissue.

Glucosamine can be taken as a separate drug, or it can be part of complex means. Available in forms such as gel, balm, ointments, tablets and injections.

Gels and ointments

Although it is generally accepted that glucosamine chondroitin complex is effective when taken orally, formulas have been created for external use containing both components. Thus, we can isolate a gel, the composition of which contains glucosamine sulfate, chondroitin sulfate and additional components (cinquefoil extract, collection essential oils and D-panthenol).

The gel is prescribed for the following indications:

osteoarthritis, affecting the joints and spine;
if an injury is sustained (dislocations, bruises, fractures), in order to better restore tissue;
increased loads when playing sports;
preventive treatment for elderly and frail people.

The combination of glucosamine and chondroitin affects collagen, or rather, its production and strengthening. The gel, penetrating into the tissue, slows down the process of joint destruction and strengthens cartilage. Also, a gel containing glucosamine chondroitin has the advantage that it contains D-panthenol with a wound-healing and conductive effect and essential oils.

If the gel is used for inflammation or injury, the processes of restoration of joint cartilage tissue are stimulated, pain syndrome is reduced, the process of fluid formation in the joint is improved and collagen is strengthened. The course of treatment is calculated from several weeks to 3 months, while applying the gel 2-3 times a day. For better effect the complex can be taken orally.

For local application You can take a cream-balm that needs to be rubbed into areas of inflammation and pain. The balm provides joint tissue with active components for regeneration and reduction of inflammation. The balm is also recommended for use as a preventive measure to stop the aging process and destruction of the joint apparatus.

The balm with chondroitin and glucosamine has a composition with additional components, including sea buckthorn and eucalyptus oils; it also contains menthol, camphor, St. John's wort and other components. The product should be taken topically and it is better to consult a doctor about the duration of treatment and the number of applications to the skin.

Complex for sports

Sports nutrition is on par with visiting the gym for real athletes. That is why complexes containing chondroitin glucosamine are also designed to support the ligamentous apparatus in athletes and people with an active lifestyle.

It is not uncommon for former athletes to begin to suffer from pathologies of the joints and spine with age due to numerous injuries and overloads throughout their lives.

This is due to the fact that during exercise, collagen, vitamins and minerals are lost, and tissue metabolism is disrupted. Thus, doctors have created an ultra-complex containing glucosamine and chondroitin for sports nutrition.

It is better to take the complex in a course, this will better preserve the integrity of the joints.
In addition, sports nutrition additionally contains chondroitin complex plus zinc and methyl sulfatemethane. If you take the complex, you can observe the following effect:

the frequency of pain after exercise and injury is reduced;
joints cope better with the load;
Collagen is produced in sufficient quantities.

It is the complex of all substances that allows for a better effect on the human body, and the product is safe to take. The norm per 100 g of fat and protein is zero, calories - up to 131 kcal, and carbohydrates - up to 52.4 g.

Meals are taken twice a day by mixing the contents of a measuring spoon into a glass of water. If desired, you can help the production of collagen by consuming foods such as jelly, jellied meat, and jellies.

Conditions of release, storage and sale

To prevent the medicine from losing its medicinal properties ahead of time, it should be stored correctly - in a dark place at a temperature not lower than 15 and not higher than 25 degrees. Chondroxide Glucosamine should be kept out of the reach of children. The shelf life of the product is three years.

You can buy the supplement at any pharmacy or specialized online store. Glucosamine Chondroitin analogues are also not expensive (Russian production) - on average 4000 rubles. The average cost of a medicine from a foreign manufacturer is 2,000 rubles.