Unsuccessful IVF - one, two, three, four, five - how not to despair again? What to do next with unsuccessful eco

Perhaps the vast majority of couples who want to have children are faced with the problem of pregnancy, when each unsuccessful case increases the uncertainty in the possibility of having children, despair appears.

In the event that the long-awaited pregnancy does not occur within a year, subject to an active sexual life and the couple's attempts to conceive a child, when contacting a doctor, they receive a disappointing status - infertility.

It's important to know! More than 50% of couples diagnosed with infertility, after undergoing a course of treatment, following the doctor's recommendations, eventually get the desired pregnancy naturally.

In the case when all negative reasons are excluded, the couple is physiologically healthy, or has health limitations for conceiving a child naturally, their chance to become parents may be IVF, i.e. in vitro fertilization.

The reason for the use of IVF technology is the following indications that characterize the health of each member of the couple:

diagnosis of infertility in a woman;
the diagnosis of infertility in a man;
couple's infertility diagnosis.

IVF use case, it is an opportunity for a couple to endure and give birth healthy child. Because technology used to bypass weak spots v reproductive function couples, when the egg is fertilized outside the woman's body, and in laboratory conditions, and the doctor transfers the already viable embryo to the uterus.

Interesting! If future parents have high risk the occurrence of severe genetic diseases, when an unsuccessful pregnancy outcome is practically guaranteed, IVF involves the analysis of embryos obtained during artificial insemination for the presence of pathology in order to prevent dangerous disease The child has.

A contraindication for the use of the IVF method is the inability of a woman to endure a pregnancy, when its onset can provoke risks to life and health, or obviously lead to pathology in the development of the fetus.

In vitro fertilization procedure (stages, protocols)

IVF is carried out in accordance with the individual sequence of hormone therapy for a woman, developed by a doctor, so an unsuccessful result is minimized. The methods used to introduce drugs into the body are called protocols, and are divided into two main types: long and short. The division is due to the duration of therapy, as the name implies.

The long IVF protocol assumes the duration of the hormonal effect on reproductive system women up to 50 days. Used for women with gynecological diseases(eg, endometriosis, fibroids). A negative feature of this technique is the danger of ovarian hyperstimulation.

Short protocol, suggests duration hormone therapy no more than 2 weeks, and begins immediately with ovarian stimulation. The use of this IVF protocol is recommended for women who do not have ovarian problems.

Interesting video:

Briefly, the IVF procedure is as follows:

hormonal stimulation of the ovaries, depending on the protocol chosen by the doctor, as a result of which ovulation gives a large number of eggs in one procedure;
egg retrieval from a woman (occurs under the control ultrasound), and the collection of sperm from a man;
fertilization of the egg is carried out in the embryological laboratory, after which it is considered an embryo and kept in an artificial environment for up to 5 days, which is necessary for analysis of genetic pathologies.
It is curious that even at the stage of embryonic development in the laboratory, modern technologies allow you to determine the sex of the unborn child.
transfer of embryos into the uterus of a woman;
hormonal maintenance of the body with progesterone, in order to prevent abortion;
conducting a blood test for the hCG hormone, 2 weeks after the transfer of the embryo into the body (when a delay in menstruation is obvious). Based on the results obtained, either further management of the pregnancy continues, or an unsuccessful IVF result is recognized.

From the point of view of medicine, children who have received a chance at life as a result of the in vitro fertilization procedure are no different from those that are conceived in a natural way. So future parents should not reject this method solutions to the problem of infertility due to hidden prejudices.

Causes of failure in IVF

A disappointing fact, but many couples who are familiar with the problem of infertility understand that an unsuccessful IVF attempt for the first time, there is no guarantee that it will work out the second. But the lack of results this case is also important, because this is an occasion to undergo a deeper examination, find the reason that caused the unsuccessful IVF result, eliminate it, and use a second chance to conceive.

Important! The reasons why IVF fails are always first of all characterized by the individual characteristics of the couple, and require an exceptional approach of the doctor when looking for treatment options.

Summarizing everything possible options failures, we highlight the key ones:

Use of embryos with pathological development, the presence of fragmentation, without pronounced activity to division, this is a frequent case of ovarian hyperstimulation. This procedure reduces the qualitative result of the material, by increasing the number of eggs received, which naturally affects the effectiveness of the IVF procedure.
An incorrect choice of IVF protocol, without taking into account the physiology of a woman, provokes an unsuccessful outcome, because. the body may not tolerate hormone therapy correctly.
Poor quality male material, ie. unhealthy spermatozoa, of course, will fertilize the egg in the laboratory, but the development of the embryo will not begin, because. for the body, this is a deliberately unsuccessful option, a pathology. The reason for bad male material usually lies in the availability infectious disease. This case is a contraindication for IVF, before full recovery men and the fence of healthy material for work.
Pathological structure of the endometrium and fallopian tubes, these reasons must be eliminated at the stage of pregnancy planning.
Inadequate hormonal support of the reproductive system, after the transfer of the embryo into the uterine cavity.
chronic diseases endocrine system women ( diabetes), also exceeding the norm of blood coagulability (thrombophilia, causing difficulty in the introduction of the embryo into the endometrium), or an immune disorder - all these reasons require the utmost attention of doctors, in order to minimize them negative impact for the IVF procedure, in order to exclude an unsuccessful attempt.

A prerequisite for the use of IVF is the examination of a couple for genetic pathologies, because an unsuccessful result may be a consequence serious illnesses parents of the unborn child. Holding this study will allow doctors to avoid critical mistakes and create the most favorable conditions for the IVF result to please future parents.

A comprehensive examination, when any, even an insignificant reason, can cause a negative result, it is important to conduct it in advance. Thus, getting time for the diagnosis and treatment of identified diseases, which will reduce the chance of an unsuccessful IVF result, which means it will give additional confidence that pregnancy will occur.

Ways to increase the likelihood of pregnancy, with repeated IVF

To increase the chances of success with repeated IVF, it is recommended to adhere to the following conditions:

the transfer of the embryo into the uterus of a woman should be carried out without any pain, and spasms, the skill of the doctor and the right tool are important here;
the thickness of the endometrium should be within 13 mm, and the structure should be three-layered, which will create the most positive conditions for fixing the embryo;
warning by doctors of excessive stimulation of the ovaries;
physical and mental health couples. positive attitude for the IVF procedure should always accompany the couple, even when this case can become an incredible exception, against the background of the fact that every unsuccessful result naturally extinguishes hope for good luck. And if you do not believe in a successful outcome, then it is strange to expect a miracle from doctors.

For many couples, any chance of becoming parents is a reason in itself to be happy and hopeful of having children. Despite the fact that the recovery of the body after an unsuccessful IVF attempt requires effort from a woman, in search peace of mind and physiological recovery, she also needs support from a man. Each unsuccessful chance is a case of unjustified expectations, and great stress, against the backdrop of a surge of negative emotions.

It is important to survive the unsuccessful result with the whole family together, and without stopping, find mental strength for repeated IVF.

An unsuccessful IVF result is a reason to think about your life, find factors that negatively affect conception, eliminate them, and boldly, with your head held high, start a new attempt. Everyone should be given the happiness of motherhood, the opportunity to be the parents of a small miracle.

Not all patients successfully conceive even after several in vitro fertilization (IVF) attempts. It becomes not only medical, but also psychological problem. Therefore, each couple should be realistic about the possible outcomes before undergoing such a procedure.

The frequency of development of a negative result

It is considered that if the first is unsuccessful, the chances of success remain for the next two attempts. However, at the fourth and subsequent attempts, the probability of pregnancy is reduced by 40% and is less than 5%. If the second IVF, and even more so the third one, was also unsuccessful, it is necessary to change the protocol of the procedure or use other options, which are described below (ZIFT and GIFT procedures).

Causes

The main reasons for unsuccessful IVF:

old age of the mother;
elevated levels of follicle-stimulating hormone (FSH);
negative reaction to medications taken to improve fertility;
a small number of received eggs;
delay in fertilization;
a small number of obtained embryos available for;
decrease in the quality of embryos, which can occur for a variety of reasons.

Sometimes even multiple IVF attempts fail for some unknown reason.

Other diseases and conditions:

chronic endometritis;
after numerous abortions or curettage;
hydrosalpinx;
genetic incompatibility of parents;
diabetes, pathology thyroid gland and others endocrine organs, which could worsen under the influence of hormonal preparation for the procedure;
obesity in both mother and father;
pathology of spermatozoa ().

If there was a failure

If IVF fails, close cooperation with the attending physician is necessary. Only he can identify the problem and find a solution. The doctor should analyze the procedure cycle in detail and determine if there are any ways to change it in order to be successful in the future. Sometimes it is enough to add 1-2 drugs for pregnancy.

At this time, it is necessary to establish a trusting relationship with your doctor. Only by understanding what is happening to her, the patient can improve the chances of successful treatment. To do this, she needs to find a specialist who will answer all her questions.

It should be understood that unsuccessful IVF - common occurrence. An example is the fact that during the normal sexual life of healthy spouses, the probability of pregnancy is no more than 7% per month. This figure is significantly lower than the efficiency of IVF.

What you need to analyze first of all with your doctor:

type of protocol, types and dosages of drugs, results of blood tests and ultrasound;
characteristics of the rate of fertilization in the laboratory, the development of embryos, their cryopreservation;
selection of new technologies, for example, the use of new drugs or the cultivation of an embryo up to 5 days;
exclusion of endometriosis, hydrosalpinx, polyps or uterine fibroids or treatment of these conditions;
diagnosis of polycystic ovary syndrome and appropriate correction of therapy.

You need to understand that most often no one is to blame for the failure. However, in the absence of confidence in the clinic where the first attempt was made, it is better to find another hospital.

Signs of a failed attempt

After IVF, you need to wait for 2 weeks. After that, the patient takes an analysis to determine the level of hCG. If the indicator did not increase compared to the original, then the procedure was unsuccessful.

Signs of unsuccessful IVF before hCG:

there are no unusual symptoms, for example: fever jumps, chills appear, feeling unwell;
remains at the level up to 37.2°;
no manifestations early toxicosis especially nausea.

After an unsuccessful attempt at in vitro fertilization, most patients to identify missed pathological changes in the uterus, which could cause miscarriage, is assigned. Sometimes, immediately in the first cycle after it, a second attempt is made, and this can contribute to the desired pregnancy.

Fertility Restoration

Recovery after an unsuccessful procedure takes up to 3 months. At the same time, it is necessary to pay attention not only to physical, but also to emotional health.

Factors that help to survive stress and recover faster:

psychological: conversation with a medical psychologist, auto-training, meditation;
physiological: sessions of acupuncture, massage, regular exercise;
biochemical: balneotherapy, healing mud, bath procedures, swimming, hardening, moderate tanning;
physical: taking soothing medicinal herbs.

assistance of a psychologist of the center of reproductive technologies;
improving relations with a spouse, since attempts to get pregnant should not turn into an end in itself for a woman;
good nutrition, adequate sleep;
communication with loved ones.

In some cases, a woman develops severe depression - thoughts about her own worthlessness appear, apathy sets in, tearfulness, a constantly depressed state, the desire to live, work, even get out of bed disappears. In this case, the help of a psychiatrist and medication is needed.

When can you try again?

It depends on the individual condition of the patient. She must again gather her courage, undergo all examinations and tests, cure existing diseases. Usually a repeat protocol is prescribed after 3 months. The number of attempts is practically unlimited, some women become pregnant only after the 6th - 8th procedure.

In some cases, cryotransfer after unsuccessful IVF is done after one menstrual cycle, that is, when the first and second menstruation ends. At the same time, the time required for the procedure is reduced, since there are already frozen embryos obtained at the first attempt. Therefore, it is not carried out, the extraction of eggs, their fertilization and cultivation. At the same time, the quality of the embryos does not suffer.

The cryoprotocol can be supplemented with hormonal therapy to support the process in the endometrium, but drugs are usually prescribed only when endocrine form female infertility.

To take advantage of this opportunity, it is necessary immediately after the failure of the first IVF to go through full examination, find and eliminate the cause of the pathology. In this case, there is a chance of pregnancy on the second attempt without an extra hormonal load on the body.

Menstrual cycle and pregnancy

Is it possible to get pregnant naturally after a failed attempt?

Yes it is possible. After a negative hCG test result has been obtained, the woman stops taking hormonal drugs.

When does menses start?

Usually, menstruation comes in the first 10 days after hormone withdrawal. If bloody issues appeared literally in the first days after IVF, you should immediately consult a doctor. This may be a sign of an abortion or ovarian hyperstimulation syndrome.

A delay in menstruation after an unsuccessful IVF can be caused by an advanced disease. To find out the reasons, you should consult a doctor and do an ultrasound.

It happens that after an unsuccessful attempt, the chest hurts. This is fine. So the body reacts to significant hormonal changes occurring during this period. After cycle recovery similar symptoms should disappear.

The first menstruation can be heavy and long (up to 10 days), sometimes there are moderate pains. Scanty menstruation during this period is often a sign of endometrial pathology or a violation hormonal background. Ovulation occurs 12-14 days after the onset of menstruation, sometimes later. At this time, the onset of a natural pregnancy is possible. If this does not happen, subsequent menstrual bleeding should be normal for the patient.

In about a third of cases, after IVF failure, natural pregnancy. It is related to diagnosis and treatment. possible diseases couples, improved hormonal levels, better preparation of the endometrium. At the same time, approximately 3-4 weeks after the first menstruation, there are initial signs- nausea, feeling unwell, sometimes the lower abdomen hurts. If such pain becomes stronger, accompanied by bleeding from the vagina, you should immediately consult a doctor. These symptoms may be a sign of a miscarriage. early term. Pain in the abdomen may occur earlier than the specified period. They also require a consultation with a gynecologist or reproductive specialist to rule out ovarian hyperstimulation syndrome.

Physiological pregnancy after unsuccessful IVF develops normally. A woman should see a doctor regularly. She can give birth naturally.

Medical solutions to the problem

For all couples faced with such a situation, the question arises - what to do next?

Usually the couple is asked to try again. How to prepare for your next IVF procedure:

Rediagnosis

Conduct repeated diagnostic tests if the previous results were obtained more than a year ago:

Determine the level of antisperm and antiphospholipid antibodies. Antiphospholipid antibodies interfere with normal uterine blood flow and embryo implantation. Positive antisperm antibodies damage the embryo immediately after implantation, when the woman does not even know that she managed to get pregnant.
Examine the level of lupus coagulant, antibodies to hCG, sow the contents of the endometrium on nutrient medium to identify possible pathogens of chronic endometritis.
Assign to exclude the accumulation of fluid in the pipes (hydrosalpinx). It can enter the uterus and be a toxin for the implanted embryo.
An ultrasound of the uterus is performed with filling its cavity with a sterile solution (hydrosonography) to exclude fibroids or polyps.
If necessary, prescribe dopplerography of the vessels of the uterus and pelvic organs, exclude varicose veins veins in this area.

Ovarian stimulation

They are convinced of the maximum possible for the patient at her age. Any clinic tries to avoid ovarian hyperstimulation syndrome. With this pathology, the ovaries enlarge and secrete into abdominal cavity large amounts of fluid, which can be life-threatening.

Although this risk should be taken very seriously, reducing the amount of hormonal preparations below a safe level leads to a decrease in the normal stimulation of egg production in the follicles, a decrease in their number, a deterioration in the quality of the resulting egg, and then the embryo, and a decrease in the success rate of repeated IVF. With a decrease in drug stimulation of the ovaries, the number of eggs may not decrease, but each of them receives less hormonal exposure, which leads to its underdevelopment.

Search for another clinic

Unsuccessful IVF attempts are a reason to look for another clinic that uses other artificial insemination programs. There are several such protocols, and in each of them medical centers usually stick to one. If it does not work, more information needs to be collected on other reproductive centers.

Using Helper Methods

To improve the efficiency of IVF, auxiliary methods can be used:

"Assisted hatching" is the application of a microscopic hole in the wall of an embryo to help it "hatch" before implantation in the uterus.
Co-cultivation, that is, the joint development of the embryo with endometrial cells obtained from the uterine wall.
, in which 1 cell is taken from a 3-day-old embryo, which is subjected to chromosomal analysis.
Preventive removal of the fallopian tube with large hydrosalpinx.
Prolongation of cultivation "in vitro" up to 5 days, until the formation is no longer a zygote, but a larger formation - a blastocyst.
Adding to the Hormone Therapy Protocol growth hormone necessary for the full maturation of the egg, most often in young patients with a large number of received eggs or in women over 38 years of age.

Application of analog technologies

How to increase the chances of success of retries? If all were taken into account possible factors, but the pregnancy never occurred, you can apply other technologies:

Use taken from another woman.
ZIFT is a procedure in which own eggs are retrieved and fertilized in the same way as in IVF, but after that they are not incubated, but during the first 2 days they are transferred into the fallopian tube through laparoscopy.
GIFT is a procedure in which eggs are obtained either by transvaginal aspiration (suction or laparoscopy), immediately mixed with sperm and immediately placed in the fallopian tube.

ZIFT and GIFT technologies allow a fertilized egg to immediately enter its physiological environment - the fallopian tube. As a result, there is a more harmonious development of the embryo, the influence of the beneficial factors contained in the tubes on it, " independent choice» the place and time for implantation in the uterus. This increases the chance of pregnancy from 5% to 40%.

The in vitro fertilization procedure is constantly being modernized and is becoming available to many childless couples. But, it does not always end with the desired pregnancy. Doctors consider the reasons for unsuccessful IVF in each individual case individually.

Diseases of the female genital organs

Thorough examination and productive treatment help to avoid unsuccessful attempts. It is important to remember that the problems listed below are not a sentence. Some genetic diseases, are inherited only at a certain stage, and with immune deviations, drugs are prescribed.

The age of the woman. Among the patients, many ladies over the age of 40 years. Over the years, even healthy woman the functions of the reproductive system are reduced. And for those who have problems with conceiving and carrying a pregnancy, artificial insemination at this age cannot always help. In addition, it takes much more time to rehabilitation period, after failure. The age of the potential father also has an impact. In men older than 45 years, the quality and motility of spermatozoa decreases.

endocrine problems. Stimulation of ovulation can provoke an exacerbation of previously existing diseases that have not been fully cured. Consultation with an endocrinologist is necessary if diabetes mellitus, hypothyroidism, hyperthyroidism and other diseases associated with the endocrine system are diagnosed.

Excess weight. Obesity in most cases is an obstacle to pregnancy. Before making a new attempt, it is worth getting rid of extra pounds. Obesity needs to be cured not only expectant mother but also to a father who has excess weight. In obese men, a poor spermogram is often detected, which is why low-quality embryos ripen and die in the uterine cavity.

Therefore, highly qualified doctors insist on a thorough examination of married couples before entering into the protocol and a responsible attitude when choosing a clinic for the procedure.

Physiological recovery

After an abortion, recovery after an unsuccessful IVF, each woman takes an unequal time. Maybe there is a lack of menstruation or profuse bleeding. The first menstruation should begin 5-7 days after implantation or unsuccessful cryotransfer, and then observed irregular cycle. None of these circumstances are out of the ordinary.

Within 1 - 3 months, the menstrual cycle should be restored, its failure is due to hormonal changes in organism. If this does not happen, you should consult a gynecologist.

Most often, starting from the second unsuccessful attempt, many patients complain of weight gain. For some, this is about two kilograms, for someone - more than ten. main reason weight gain - hormonal imbalance leading to metabolic disorders.

It is possible, but it is not easy to do so. Losing weight after the protocol is more difficult than removing it overweight due to malnutrition. In order to return to the previous form, you should not only monitor your diet, but also increase physical activity.

Is it possible on your own? According to statistics, in almost 30%, a woman became pregnant after an unsuccessful IVF in a natural way. This is due to the stimulating procedures carried out during the period of being in the protocol, which gave impetus to the activation of the physiological hormonal cycle after the procedure.

Rehabilitation after failure

In vitro fertilization is not only a big financial, physical, but also mental cost. For many, life after unsuccessful IVF is difficult psychologically. During this period, a woman needs the support of her husband and loved ones. Therefore, before the procedure, it is important to prepare both physically and mentally in order to know how to behave after an unsuccessful IVF.

How to Survive a Failed IVF:

speak out and cry a lot right away, for the first time days after the protocol;
visit regularly gym or fitness club. This will not only distract, but also help you get in shape;
find an interesting activity: sign up for driving courses, study foreign languages, attend master classes on cutting and sewing, knitting, beading, drawing;
get excited about reading. Buy interesting literature, or visit the library and read as much as possible. Exciting works will help distract from sad thoughts;
believers, good moral support will be provided by a visit to the temple and a conversation with a clergyman.

You should not dive into an unsuccessful attempt and try to look for the guilty, blame the doctors for everything, considering them to be non-professionals. No need to self-flagellate or blame your spouse and constantly quarrel with him.

Increasing the odds

A failed IVF attempt should be an incentive to more thorough examination, elimination of existing problems, aftercare of neglected diseases.

It is required to give the body time to rest from increased doses of hormones, not to take any medications without consulting a doctor. At least two months must elapse before a new attempt. A more accurate period, the doctor will help to establish, depending on the individual characteristics of the organism.

To increase your chances of achieving positive result in the following protocol, the attending physician may issue a referral for physiotherapy, acupuncture, hirudotherapy. Some women need a consultation with a psychologist. To distract from failure and restore strength for the subsequent procedure will help Spa treatment. Contact with viral patients should be excluded, stressful situations should be avoided.

If possible, contact a clinic that uses the latest techniques during IVF. One of them is laser hatching. This is a procedure in which laser beams dissect the shell of the embryo, as a result of which it takes root better.

Empirically, it was found that if the causes of unsuccessful embryo transfer could not be excluded after 4-5 attempts, then in the future the chances noticeably drop. In such a situation, doctors recommend using other methods of getting rid of infertility. For example, use donor biomaterial, or agree to surrogate motherhood.

Preparing for IVF is a long process. Given the fact that for couples who decide on this procedure, artificial insemination becomes, without exaggeration, the last hope, after numerous attempts to conceive a child and long treatment, they have very high hopes for IVF. The more painful is the realization that the first attempt was unsuccessful. We hasten to reassure: this is exactly what happens in most cases. Why IVF fails the first time? Let's list the most common reasons.

In cases of viral and bacterial infections the likelihood of successful IVF is reduced

The older the woman, the less likely that the embryo will immediately take root, because with age, fertility decreases - after 35 years, and especially after 38. During this period, success is no more than 15%, while for women aged about 30 years - 35%. Often the numbers are even lower; to determine potential fertility, there are special tests - for example, a reaction to clomiphene or a measurement of the third day, which assesses the level of FGS in the blood.

Poor embryo quality

There is no unified system for assessing the quality of embryos in the world, but, as a rule, the following parameters are used: - correct shape; - crushing speed (the higher it is, the better). An embryo that will be implanted in a woman should have 8 cells on the third day. As a rule, the transfer is carried out exactly on the third day, with the exception of some cases (such as cryopreservation), when a five-day wait is advisable; - the absence of fragments. An embryo is considered unsuitable for replanting if the fragmentation is 50 percent or more.

Infectious and viral diseases

ARVI and especially influenza have a negative impact on the reproductive system, since during the illness toxic substances are produced that affect, among other things, the uterine cavity. In addition, for the treatment of these diseases are often used antibacterial drugs. On their own at correct selection they don't provide negative impact on fertility, but can become dangerous in combination with hormonal drugs.

Changes in the endometrium

In order for successful implantation to occur, and then for the development of the embryo, it is necessary that the endometrium is mature, of the required thickness and with a structure that meets the standards. It is generally accepted that before implantation, its thickness should be at least 7 millimeters. Usually this parameter is determined by ultrasound before the start of hormonal stimulation, so that the doctor can prescribe additional drugs, which do not prevent the maturation of the follicles, but at the same time contribute to an increase in the thickness of the endometrium.

The wrong stimulation

The most important stage of in vitro fertilization is ovarian stimulation to increase the number of maturing follicles containing eggs. If the types or dose of drugs were chosen incorrectly, the goal will not be achieved: the number of follicles will remain minimal or their quality will be unsatisfactory.

Pathology of the fallopian tubes

In before the procedure is always assigned special study Helping to identify diseases of the fallopian tubes. For example, one of them is hydrosalpinx, which is an accumulation of fluid as a result of inflammatory processes. Moreover, stimulation of ovulation before IVF is one of the factors that contribute to the growth of hydrosalpinxes.

The consequences of unsuccessful IVF can be severe, both in the reproductive aspect and in the psychological aspect. And if her relatives and herself are more responsible for the moral state of the patient, then doctors will have to prevent future unpleasant surprises that may appear in the process of infertility treatment.

The clinic "IVF Center" closely monitors the reaction of the body of a particular patient to a particular therapy. We try to figure out what went wrong as soon as possible so that the next attempt will be successful.

Unsuccessful IVF attempts: causes of non-pregnancy

Immediately, we note that each attempt of in vitro fertilization gives about forty percent of the probability of a successful outcome. At the same time, pregnancy after the first replanting is a rarity, and patients are always warned about this.

Consider the most common causes of unsuccessful IVF:

unpreparedness female body to pregnancy;
hormonal disruptions;
diseases or pathologies of the endometrium;
diseases of the fallopian tubes;
decrease in ovarian reserve;
insufficient response of the ovaries to ovulation stimulation;
poor sperm quality;
poor quality of the obtained embryos;
autoimmune factors (rejection of the embryo by the mother's body);
chromosomal disorders;
similarity of tissue compatibility antigens in parents;
infections.

Why the body may not be ready for pregnancy? It is not recommended to carry out fertilization during an exacerbation of any diseases (not necessarily gynecological). That is why before preparing for IVF, you need to pass so many tests. It is better not to rush, to fully recover and thereby increase the likelihood successful conception. The presence of infection is also an easily eliminated factor: by the next cycle, the chances of a successful implantation of the embryo will be higher.

As for hormonal failure, most often it is caused by ovarian hyperstimulation syndrome. It is possible that the chosen protocol did not suit the patient, and the scheme of preparation for fertilization should be changed. The same applies to insufficient response to stimulation: a different protocol or replacement of drugs is needed.

For successful implantation of the embryo, the thickness of the endometrium must be between 7 and 14 mm. The doctors of the clinic "IVF Center" always carefully monitor the observance of this condition, however, in general, unsuccessful IVF, according to reviews, is often due to the unavailability of the inner layer of the uterus.

To exclude autoimmune factors, it is necessary to donate blood for an immunogram, which detects the presence of killer cells. Both parents should consult a geneticist to determine possible chromosomal abnormalities or antigen similarities.

Signs of failed IVF

When does it become clear that the procedure has not been successful? Two weeks after the implantation of the embryo will pass in agonizing expectation. This expectation always makes a woman listen sensitively to her body and look for the slightest changes. The most accurate indicator of pregnancy is an increase in the blood level of the hormone hCG. If this is not observed, IVF has failed. Then it's time to find out the reasons for unsuccessful IVF, but, according to reviews, there are other alarming signals.

There are a few more characteristic features pregnancy after IVF. The restructuring of the female body, combined with a slight weakening of the immune system as a result of in vitro fertilization and the procedures preceding it, will noticeably worsen your well-being. The condition will be similar to a cold, and basal body temperature will rise to 37.2º. If you do not feel anything like this, most likely, the pregnancy has not occurred.

Toxicosis, and rather early, is an indispensable companion of pregnancy resulting from IVF. With natural conception, some women manage to avoid such unpleasant symptom. But after the use of assisted reproductive technologies, toxicosis occurs with a 100% probability. This is due to the effect of stimulating superovulation. So if you don't feel sick, unfortunately IVF failed.

But do not rush to despair! Immediately contact the clinic "IVF Center" to find out why unsuccessful IVF is taking place in your particular case. Our specialists will establish the causes and will be ready to correct the error by the next protocol.

Start your journey to happiness - right now!