Analgin has analgesic, antipyretic and moderate anti-inflammatory effects. Inhibits the activity of cyclooxygenase, reduces the formation of endoperoxides, bradykinins, some prostaglandins, free radicals, and inhibits lipid peroxidation. It prevents the conduction of painful extra- and proprioceptive impulses along the Gaulle and Burdach bundles, increases the threshold of excitability of the thalamic centers of pain sensitivity, and increases heat transfer.
Pharmacokinetics
When taken orally, analgin (metamizole) is quickly and completely absorbed. In the intestinal wall it is hydrolyzed to form an active metabolite; There is no unchanged metamizole in the blood. Metabolized in the liver. The active metabolite 4-methyl-aminoantipyrine is in turn metabolized to 4-formyl-aminoantipyrine and other metabolites. The level of binding of the active metabolite to proteins is 50-60%. When taken in therapeutic doses, it penetrates into mother's milk. Metabolites are excreted by the kidneys. The effect develops within 20-40 minutes and reaches a maximum 2 hours after ingestion.
Indications for use
Fever syndrome: infectious inflammatory diseases, insect bites - mosquitoes, bees, gadflies, etc., post-transfusion complications.
Pain syndrome mild and moderate severity: neuralgia, myalgia, arthralgia, biliary colic, renal colic, injuries, burns, decompression sickness, herpes zoster, orchitis, radiculitis, myositis, postoperative pain syndrome, headache, toothache, algodismenorrhea.
Contraindications
Hypersensitivity (including to pyrazolone derivatives), inhibition of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia), liver and/or renal failure, hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase, bronchial asthma induced by taking acetylsalicylic acid, or other anti-inflammatory drugs, anemia, leukopenia, acute porphyria, childhood up to 10 years.
Carefully: kidney disease (pyelonephritis, glomerulonephritis - including a history), long-term alcohol abuse.
Directions for use and doses
Prescribed orally, after meals, the frequency of administration is 2-3 times a day. Children aged 10-14 years (32-52 kg) - single dose 1 tablet (500 mg), maximum daily dose- 4 tablets (2000 mg). Children over 15 years of age (>53 kg) and adults - a single dose of 1-2 tablets (500-1000 mg), maximum daily dose - 6 tablets (3000 mg).
Side effect
From the urinary system: renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, staining urine red.
From the hematopoietic organs: agranulocytosis, leukopenia, thrombocytopenia. Allergic reactions: urticaria (including on the conjunctiva and mucous membranes of the nasopharynx), Quincke's edema, in rare cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome, anaphylactic shock.
Others: decline blood pressure.
Overdose
Symptoms: nausea, vomiting, gastralgia, oliguria, hypothermia, decreased blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and/or liver failure, convulsions, paralysis of the respiratory muscles.
Treatment: induction of vomiting, transtube gastric lavage, administration of saline laxatives, activated carbon, forced diuresis, hemodialysis, if developing convulsive syndrome- intravenous administration of diazepam and fast-acting barbiturates. Symptomatic therapy, maintaining vital functions.medicines"type="checkbox">
Interaction with other drugs
Enhances the effects of ethanol. The effect of analgin is enhanced by barbiturates, codeine, histamine H 2 blockers, and propranolol (slows down inactivation). Thiamazole and cytostatics increase the likelihood of developing leukopenia. Analgin, displacing oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin from protein binding, increases their activity. Reduces the concentration of cyclosporine in plasma. Concomitant use of the drug with other non-steroidal anti-inflammatory drugs may lead to mutual enhancement toxic effects. Tricyclic antidepressants, oral contraceptives and allopurinol disrupt metabolism and increase the toxicity of the drug. Sedatives and tranquilizers enhance the analgesic effect of analgin. Phenylbutazone, barbiturates and other hepatoinducers, when administered simultaneously, reduce the effectiveness of metamizole sodium. Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.
Features of application
X-ray contrast agents, colloidal blood substitutes and penicillin should not be used during treatment. With long-term use it is necessary to monitor
picture peripheral blood. It is unacceptable to use it to relieve acute abdominal pain until the cause is determined.
Use during pregnancy and lactation. The use of the drug is contraindicated in the first and last trimesters of pregnancy, during lactation (breastfeeding is stopped during treatment).
Precautionary measures
In patients receiving cytotoxic drugs, analgin should be taken only under medical supervision. In patients with atopic bronchial asthma and hay fever is present increased risk development allergic reactions.
In elderly patients, the dose of analgin should be reduced, since the excretion of analgin metabolites is slowed down. In patients with severe somatic status and impaired creatinine clearance, the dose should be reduced, since the elimination of metabolites is slow.
Regular long-term use is not recommended due to myelotoxicity. While taking analgin, agranulocytosis may develop, and therefore, if an unmotivated rise in temperature, chills, sore throat, difficulty swallowing, stomatitis, or the development of vaginitis or proctitis is detected, immediate discontinuation of the drug is necessary. When prescribed to patients with acute cardiovascular pathology, careful monitoring of hemodynamics is necessary.
Use with caution in patients with blood pressure levels below 100 mmHg. Art., with anamnestic indications of kidney disease (pyelonephritis, glomerulonephritis) and with a long history of alcoholism.
Impact on the ability to drive vehicles and other potentially dangerous mechanisms. Does not affect the ability to drive vehicles and other potentially dangerous mechanisms.
Release form
10 tablets in a blister pack or in a blister-free pack. One package at a time along with instructions for use is placed in a cardboard pack. Packaging for hospitals: 120 contour cell-free packages or 150 contour cell packaging with instructions for use are placed in a cardboard box.
Analgin is an effective analgesic (pain reliever) drug that helps quickly eliminate moderate or severe pain in the body.
In addition to the analgesic effect, medicine has a pronounced anti-inflammatory property, which can significantly reduce the resulting area of the inflammatory process.
The drug allows you to quickly eliminate pain, so it can be easily used to relieve (eliminate) pain of a completely different nature and intensity (toothache or headache, various injuries, pain during menstruation, acute inflammatory diseases accompanied by severe pain, etc.).
Analgin is quite effective in helping with abdominal pain ( intestinal colic ah), since the drug has a good antispasmodic effect, at the same time, it can be safely combined with antispasmodics No-shpa or Papaverine.
Main indications for use of Analgin:
- acute or chronic inflammatory diseases respiratory system organism, which are accompanied by an increase in body temperature and painful sensations(bronchitis, tracheitis, pneumonia);
- severe toothache or headache;
- fever;
- renal or hepatic colic (Analgin is mainly used in combination with antispasmodics);
- neuralgia;
- severe pain in the heart;
- pain during menstruation in women;
- injuries of various types (bruise, injury, dislocation, sprain, fracture, etc.);
- burn;
- diseases of the musculoskeletal system (sciatica, rheumatism, arthritis);
- migraine;
- postoperative period;
- intestinal colic;
- myocarditis;
- pain syndrome in acute pancreatitis.
Remember: Before using Analgin, it is recommended to consult a physician to prevent possible development allergic reaction to this medication.
The drug is produced in the form of tablets of 250 or 500 mg, for children rectal suppositories(suppositories), as well as an injection solution for intramuscular, subcutaneous or intravenous administration.
How to take Analgin?
The minimum interval (length of time) between taking Analgin tablets should be at least 4-6 hours. The average course of treatment is 5-7 days.
For children, the average dose of Analgin in tablets is ½ - ¼ t. (125/250 mg.) 2-3 r. per day depending on the age of the child. In the form of an injection solution, the daily dose of the drug is calculated based on the specific age of the child and is 0.1 ml. for each year of life (for example: for a 2-year-old child, the daily dose of Analgin is 0.2 ml, similarly for a 7-year-old child - 0.7 ml).
Attention: the drug is used only for short-term analgesia (pain relief), while Analgin is strictly contraindicated for long-term or frequent use.
Contraindications to the use of Analgin
- individual intolerance to the main components of the drug by the body;
- It is not recommended to administer to children under 1 year of age;
- liver and kidney failure;
- dysmenorrhea;
- pregnancy.
Side effects of Analgin
The most common adverse reactions after long-term use There are analgin.
Self-medicating is a risky business. However, what should you do if you suddenly have a headache or a toothache, and the clinic appointment time is over? With such life situations most will reach out to home medicine cabinet for a proven remedy. However, before taking the medicine, you need to know everything about its dosage, adverse reactions. For example, it will give Additional information about the principles of action of the drug Metamizole or Analgin - instructions for use.
What is Analgin
It is known that Analgin is a simple non-steroidal drug from the pyrazoles group, which has antipyretic and analgesic properties. The working name of Analgin is metamizole sodium. It is necessary to know the second name of the tablets in order not to overpay when purchasing analogue drugs. Often expensive drugs at the bottom of the box there is the inscription metamizole sodium or metamizole natricum - this means that you bought the most ordinary Analgin, but at an inflated price.
What does Analgin help with?
Due to the features chemical composition Analgin can relieve pain and relieve fever, but has a weak anti-inflammatory effect. Due to this, the medicine is often used to eliminate the activity of pain syndromes and lower body temperature, but never to treat the inflammatory process. Summarizing all of the above, we can safely say that Analgin helps if you have:
- moderate intensity or weak pain syndrome(migraines, headaches or toothaches, cystitis, myositis, radiculitis, intercostal neuralgia, biliary or intestinal colic);
- in case of disruption of the functional course of menstruation and dysmenorrhea;
- burns medium degree, postoperative incisions, injuries;
- infectious and inflammatory processes in the area respiratory tract(pneumonia, ARVI, influenza, otitis media and other diseases);
- when complications occur after blood transfusion.
Composition of Analgin
Main active substance The drug is sodium phenyl-dimethyl-methylaminopyrazolone methanesulfonate or, simply put, metamizole sodium. Analgin of all forms and varieties includes only this component without any excipients. In appearance, it is a white powder without a characteristic odor, which reacts well with water, but is poorly soluble in alcohol. However, the composition of Analgin in combined action tablets, in addition to metamizole, includes another component - quinine.
Release form of Analgin
A popular form of release of Analgin is tablets, dragees or capsules. However, it is no less common medicinal drug in ampoules or as a component of an injection solution. It is worth knowing that suppositories for rectal use called Spazdolzin are also a derivative of Analgin. All medicinal varieties of the drug differ from each other only in the content of metamizole. Eg:
- Standard dosage active ingredients tablets is 500 mg per 1 piece.
- Analgin in ampoules contains 250/500 mg of the substance per 1 or 2 ml.
- There is also a special preparation for children. The concentration of metamizole is 50/100/150 mg.
- Spazdolzin suppositories for adults contain 650 mg of the substance, and the children's version contains 200 mg.
How to take Analgin
When using Analgin, you should remember that the drug only relieves symptoms - it relieves pain, relieves fever, but does not cure the disease itself that caused such phenomena. Each dosage form used in a specific case. For example, it is better to take Analgin tablets if you have a severe headache or toothache. Adults can take one capsule to relieve biliary or intestinal colic. It is advisable to give injections only if there is high temperature.
Instructions for use of Analgin tablets
The dosage of Analgin in capsules depends on the patient’s age, the intensity of pain and the body’s reaction to taking medications. To start treatment, it is better to choose the minimum dosage that can relieve vasospasm and reduce fever. Round tablets are easy to swallow, but it is still recommended to take them with plenty of liquid - warm milk, still water.
Instructions for use of Analgin tablets indicate that for children over ten years of age and adolescents, a simultaneous dose of the drug should be selected at the rate of 8-16 mg of metamizole per 1 kg of weight.
For adults daily norm can be increased to 1000 mg at a time. The table below will help calculate the required number of tablets according to the patient’s age and weight:
As indicated in the instructions for use, the calculated dosages should be reduced when treating headaches or relieving fever in elderly patients, since the excretion of the metabolite from the body through urine will be slower. In addition, people with impaired liver or kidney function should consult a doctor before taking the pill. If any of the above changes occur long-term treatment Analgin is unacceptable.
Instructions for Analgin in ampoules
Subcutaneous injection of Analgin is unacceptable, as it can lead to severe allergic reactions and inflammatory process. Injections of any dosage are given only intravenously or intramuscularly. It is advisable to do injections only when other drugs do not help or the person is in critical condition and cannot take the pill.
According to the instructions for Analgin in ampoules, the dosage of the drug is calculated according to the patient’s age, for example:
- Adolescents over 14 years of age and adults are administered up to 2500 mg of metamizole sodium per injection, and the maximum daily volume is 5000 mg. Analgin injections are given up to 3 times a day, keeping a 4-hour interval between them.
- Analgin is administered to children with fever minimum dosage, calculated from the ratio of 4-10 mg per 1 kg of weight. The result obtained must be divided by 2, and the drug should be administered 2-3 times per day.
The injected solution for injection must be within body temperature, so after drawing the liquid into the syringe, it must be warmed in the palms for some time. The injection is usually administered intramuscularly, but in critical conditions it is permissible to inject intravenously. Storing opened ampoules on the table, in the refrigerator or other places is strictly prohibited. If the drug has been left in open form more than 15 minutes, it is considered unsuitable for use.
Instructions for use of Analgin for children
Metamizole sodium in tablets or injections can be given to a child from the age of 10, otherwise the body's reaction may be unpredictable - as indicated in the instructions for use. For younger children age group it is customary to treat with rectal suppositories, since they provide due therapeutic effect without harmful effects on the stomach and the baby’s body as a whole.
Instructions for use of Analgin for children indicate the need to comply correct dosages. If these are suppositories, then children under one year old are usually given 1 capsule per day. Children over 2 years old can use two candles per day. As for tablets and solutions, the dosages remain the same and are calculated strictly according to the child’s weight. Parents should understand that regular use of Analgin does not guarantee recovery and can cause a lot of negative reactions.
Overdose
Excessive medication use can lead to the following symptoms:
- nausea, vomiting, stomach pain;
- increased heart rate, decreased blood pressure and body temperature below normal;
- the appearance of drowsiness, weakness, tinnitus, impaired consciousness;
- hemorrhagic syndrome, blood disorders;
- pathologies of the liver or kidneys;
- paralysis of the respiratory system.
In case of overdose, it is important to provide first aid to the victim in a timely manner. To do this, it is necessary to perform gastric lavage and induce artificial vomiting, if there is none. After this, it is advisable to give the patient cleansing sorbents or laxatives: Magnesia, Polysorb, Filtrum, Enterosgel, Activated carbon. If a similar phenomenon occurs in the hospital, then hemodialysis is performed.
Side effects
As a rule, taking tablets with metamizole sodium occurs without any consequences for humans. However, due to individual reactions of the body, negative reactions from various systems and organs may occur. Side effects Analgin can lead to the following disorders:
- Cardiac system: decreased blood pressure.
- In the form of allergic reactions: the appearance of a rash, bronchial asthma, shortness of breath, Quincke's edema.
- The effect of Analgin on the nervous system: convulsions, migraines.
- Hematopoiesis: decrease in the number of leukocytes, platelets, basophils and eosinophils.
- From the outside urinary system: difficulty in urine output, appearance of protein, red coloration of stool, development of nephritis.
- Reactions from digestive system: stomach pain, dry mouth, nausea.
Contraindications
The instructions for use indicate that due to absorption active substance V breast milk It is unacceptable to take Analgin during lactation. Since there is no reliable data on the safety of the medicine for the fetus, the medicine cannot be recommended during pregnancy, especially in the last and first trimester. Otherwise, the contraindications of Analgin are as follows:
- sensitivity to the active component;
- bronchial diseases;
- dysfunction of hematopoiesis;
- acute liver failure;
- kidney pathologies;
- children up to 3 months old.
Interaction with other drugs
Analgin is not only included in many medications, but is also often used in combination with some of them. A typical example interactions with others medicines is:
- Diphenhydramine + Analgin or Suprastin + Analgin is used to reduce temperature.
- Analgin-Papaverine-Diphenhydramine – the combination is used if the patient has cold hyperthermia.
- Aspirin-Analgin is used for viral infections.
- Paracetamol + Analgin is used to lower fever in children.
- Novocaine + Analgin - a combination for pain relief.
Analogues
In many countries, Analgin is considered dangerous and is prohibited for sale due to the likelihood of agranulocytosis - the ability to affect blood cells. However, in Russia and neighboring countries this medicine can be bought everywhere at an affordable price. Still, doctors advise not to rush into making a choice, but, if possible, to purchase analogues of Analgin. Eg:
- Ibuprofen;
- Sedal-M;
- Spasmalgon;
- Pentabufen;
- Maxigan;
- Tempalgin;
- Spazgan;
- Quintalgin;
- Baralgin.
Price
You can purchase the medicine inexpensively without a doctor's prescription at any pharmacy in your city. In addition, in modern realities, many people prefer to receive medications without leaving home, because they can order through the catalog of official manufacturers or buy in an online store. When receiving tablets, ampoules or suppositories with delivery, do not forget to check the quality of the drugs, ask for a certificate and check the expiration date. You can find out how much Analgin tablets cost in Moscow from the following table:
Video
Analgesic-antipyretic
Drug: ANALGIN
Active substance: metamizole sodium
ATX code: N02BB02
KFG: Analgesic-antipyretic
Reg. number: P No. 001286/01
Registration date: 11/18/08
Owner reg. cred.: BIOSYNTHESIS (Russia) group BIOTEK MFPDC (Russia)
DOSAGE FORM, COMPOSITION AND PACKAGING
10 pieces. - cellless contour packages.
10 pieces. - contour cellular packaging (1) - cardboard packs.
The scientific information provided is general and cannot be used to make a decision about the possibility of using a particular drug.
PHARMACHOLOGIC EFFECT
Analgesic-antipyretic. It is a derivative of pyrazolone. It has an analgesic, antipyretic and anti-inflammatory effect, the mechanism of which is associated with inhibition of prostaglandin synthesis.
PHARMACOKINETICS
After oral administration, metamizole sodium is rapidly hydrolyzed into gastric juice with the formation of the active metabolite 4-methyl-amino-antipyrine, which, after absorption, is metabolized into 4-formyl-amino-antipyrine and other metabolites. After intravenous administration, metamizole sodium quickly becomes inaccessible for determination.
Metamizole sodium metabolites do not bind to plasma proteins. The largest portion of the dose is excreted in the urine in the form of metabolites. Metabolites are excreted in breast milk.
INDICATIONS
Pain syndrome of various origins(renal and biliary colic, neuralgia, myalgia; for injuries, burns, after operations; headache, toothache, menalgia). Fever in infectious and inflammatory diseases.
DOSING REGIME
Adults are prescribed 250-500 mg 2-3 times a day orally or rectally. Maximum single dose- 1 g, daily allowance- 3 g. Single doses for children aged 2-3 years are 50-100 mg; 4-5 years - 100-200 mg; 6-7 years - 200 mg; 8-14 years - 250-300 mg; frequency of administration - 2-3 times/day.
IM or IV slowly for adults - 250-500 mg 2-3 times a day. Maximum single dose- 1 g, daily allowance- 2 g. In children, it is used parenterally at a dose of 50-100 mg per 10 kg of body weight.
SIDE EFFECT
Allergic reactions: skin rash, Quincke's edema; rarely - anaphylactic shock.
From the hematopoietic system: rarely, with long-term use - leukopenia, agranulocytosis.
Local reactions: with intramuscular injection - infiltrates at the injection site.
CONTRAINDICATIONS
Severe renal and/or liver dysfunction, glucose-6-phosphate dehydrogenase deficiency, blood diseases, increased sensitivity to pyrazolone derivatives.
PREGNANCY AND LACTATION
Use with caution during pregnancy, especially in the first trimester and in the last 6 weeks.
SPECIAL INSTRUCTIONS
With long-term use, it is necessary to monitor the peripheral blood picture.
Metamizole sodium is used in combination with pitofenone and fenpiverinium bromide as analgesic with antispasmodic effect.
Use with caution in children in the first 3 months of life.
DRUG INTERACTIONS
When used simultaneously with analgesics-antipyretics and NSAIDs, mutual enhancement of toxic effects is possible.
When used simultaneously with inducers of microsomal liver enzymes, the effectiveness of metamizole sodium may decrease.
With simultaneous use, the activity of indirect anticoagulants, oral hypoglycemic drugs, corticosteroids, and indomethacin increases due to their displacement from connection with blood proteins under the influence of metamizole sodium.
When used simultaneously with phenothiazine derivatives, severe hyperthermia is possible; With sedatives, anxiolytics - the analgesic effect of metamizole sodium is enhanced; with tricyclic antidepressants, oral contraceptives, allopurinol - the metabolism of metamizole sodium is disrupted and its toxicity increases; with caffeine - the effect of metamizole sodium is enhanced; with cyclosporine - the concentration of cyclosporine in the blood plasma decreases.
When using metamizole sodium in combination with pitofenone hydrochloride (has a direct myotropic effect on smooth muscles internal organs and causes its relaxation) and with fenpiverinium bromide (m-anticholinergic) their mutual strengthening occurs pharmacological action, which is accompanied by a decrease in pain, relaxation of smooth muscles and a decrease in elevated temperature bodies.
Analgin is a synthetic pain reliever that belongs to the group of non-narcotic analgesics.
The active ingredient of the drug is metamizole sodium. The drug has a pronounced analgesic effect, and also has an anti-inflammatory and antipyretic effect.
On this page you will find all the information about Analgin: full instructions on application to this medicine, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Analgin. Would you like to leave your opinion? Please write in the comments.
Clinical and pharmacological group
Analgesic-antipyretic. It is a derivative of pyrazolone. It has an analgesic, antipyretic and anti-inflammatory effect, the mechanism of which is associated with inhibition of prostaglandin synthesis.
Conditions for dispensing from pharmacies
The tablets are available without a prescription. To purchase suppositories and injection solution prescription required.
Prices
How much does Analgin cost? average price in pharmacies is at the level 20 rubles for tablets and 60 rubles for ampoules.
Release form and composition
A popular form of release of Analgin is tablets, dragees or capsules. However, no less common is a medicinal drug in ampoules or as a component of an injection solution. It is worth knowing that suppositories for rectal use called Spazdolzin are also a derivative of Analgin.
All medicinal varieties of the drug differ from each other only in the content of metamizole. Eg:
- The standard dosage of the active components of the tablets is 500 mg per 1 piece.
- Analgin in ampoules contains 250/500 mg of the substance per 1 or 2 ml.
- There is also a special preparation for children. The concentration of metamizole is 50/100/150 mg.
- Spazdolzin suppositories for adults contain 650 mg of the substance, and the children's version contains 200 mg.
Pharmacological effect
The active ingredient of Analgin is metamizole sodium, chemical compound from the group of pyrazolones, a non-steroidal anti-inflammatory drug (NSAID).
Reduces the production of prostaglandins - specific mediators of inflammation (anti-inflammatory effect), increases heat transfer from the body (antipyretic effect), increases the sensitivity threshold of the pain centers of the thalamus and creates obstacles to the conduction of pain impulses in the central nervous system(central analgesic effect). The anti-inflammatory effect is less pronounced than other NSAIDs, and the antipyretic effect is stronger; metamizole sodium is the most powerful antipyretic of this group. Virtually no irritation to the mucous membrane digestive tract and does not lead to disruption of water-salt metabolism. It has antispasmodic activity against the smooth muscles of the biliary and urinary tract.
Analgin begins to act 20-30 minutes after oral administration, reaching its peak after 1-2 hours. Easily absorbed into gastrointestinal tract, dissolves well in almost all medical solutions, which makes it convenient for use both orally and parenterally.
What does Analgin help with?
Due to the peculiarities of the chemical composition, Analgin can relieve pain and relieve fever, but has a weak anti-inflammatory effect. Due to this, the medicine is often used to eliminate the activity of pain syndromes and lower body temperature, but never to treat the inflammatory process.
Summarizing all of the above, we can safely say that Analgin helps if you have:
- moderate burns, postoperative incisions, injuries;
- infectious and inflammatory processes in the respiratory tract (flu, and other diseases);
- moderate intensity or mild pain syndrome (migraines, headaches or toothaches, myositis, radiculitis, biliary or intestinal colic);
- in case of disruption of the functional course of menstruation and;
- when complications occur after blood transfusion.
Contraindications
Contraindications for the use of Analgin in treatment are individual intolerance to metamizole sodium and hypersensitivity to butadione and tribuzone, blood diseases and hematopoietic disorders (neutropenia, leukopenia, agranulocytosis), bronchial asthma, “aspirin asthma”, bronchial spasms, impaired renal or liver function, hereditary hemolytic anemia, long-term ethanol abuse.
The drug is contraindicated during pregnancy. Analgin is especially dangerous in the first trimester and in the last six weeks of pregnancy. When treating with the drug, you should also suspend breast-feeding. Analgin should be given to children with special caution, strictly following the doctor’s recommendations and the prescribed dosage.
Use during pregnancy and lactation
Use with caution during pregnancy, especially in the first trimester and in the last 6 weeks.
Instructions for use Analgin
The instructions for use indicate that Analgin orally or rectally for adults is prescribed 250-500 mg 2-3 times a day. Maximum single dose– 1 g, daily allowance– 3 g. Single doses for children aged 2-3 years are 50-100 mg; 4-5 years – 100-200 mg; 6-7 years – 200 mg; 8-14 years – 250-300 mg; frequency of administration – 2-3 times/day.
IM or IV slowly for adults – 250-500 mg 2-3 times a day. Maximum single dose– 1 g, daily allowance– 2 g. In children, parenterally used at a dose of 50-100 mg per 10 kg of body weight
Side effects
When used according to indications and dosage selected in accordance with the instructions for use, Analgin is well tolerated by patients, both adults and children, and rarely causes undesirable effects.
Long-term use of Analgin can cause hematopoietic disorders, especially for granulocytes. In some countries, the drug was banned because it raised suspicions that its use leads to agranulocytosis, a blood disease directly life-threatening. However, after a series of studies it was found that the danger is significantly overestimated. Currently it is assessed as extremely low, however, such a possibility cannot be excluded.
Also, the instructions for use of Analgin indicate the possibility of allergic reactions due to individual intolerance to the drug, to a greater extent this applies to the drug administered parenterally(intravenously).
Overdose
Symptoms of an overdose of Analgin appear as:
- tinnitus;
- weaknesses;
- vomiting;
- disturbances of consciousness;
- delirium;
- expressed hypotension;
- hypothermia;
- shortness of breath;
- heartbeat;
- nausea;
- drowsiness;
- convulsive syndrome.
The possibility of developing hemorrhagic syndrome , acute agranulocytosis, hepatic And acute renal failure.
The lethal dose in tablets is from 15 to 20 grams.
Treatment: gastric lavage (the procedure is carried out using a tube), induction of vomiting, use of saline laxatives and enterosorbents, alkalinization of urine, conduction forced diuresis. Subsequently, therapy is symptomatic, aimed at regulating and maintaining the impaired functions of vital organs.
special instructions
During treatment with Analgin, it is important to take into account some points:
- you can’t take analgin for relief acute pain in the abdomen until the causes are identified, causing pain and diagnosing pathology;
- During treatment, monitoring of peripheral blood composition is required ( leukocyte formula), to prevent inhibition of hematopoiesis;
- during treatment, urine may turn red, which is associated with the excretion of metabolites (has no diagnostic value);
- the use of Analgin in the second trimester of pregnancy is possible only after a thorough assessment of the benefits to the mother and the risk to the fetus; the drug is contraindicated in the first and last 3 months of pregnancy;
- Analgin should not be taken during breastfeeding;
- taking Analgin does not affect the speed of motor and mental reactions, the ability to drive and control complex mechanisms;
- for elderly patients, as well as patients with impaired renal function (with glomerulonephritis, pyelonephritis), therapeutic doses should be reduced, since the elimination of the drug from the body may slow down;
- when prescribing Analgin to patients with acute cardiovascular disease strict control is required heart rate and blood pressure, respiratory rate;
- use with caution in patients with alcohol dependence;
- prescribe with caution to patients prone to allergies (risk of developing anaphylactic shock to the drug increases in patients with bronchial asthma, chronic urticaria, intolerance to dyes and alcohol);
- The drug is not recommended for long-term use due to its myelotoxic effect.
Drug interactions
- The simultaneous use of Analgin with Cyclosporine leads to a significant increase in the concentration of the latter.
- The simultaneous use of Analgin with barbiturates, phenylbutazone and drugs that stimulate liver activity leads to a significant decrease in therapeutic effect Analgina.
- The simultaneous use of Analgin with sedatives and tranquilizers leads to an increase in the therapeutic effect of Analgin associated with the suppression of pain.
- Simultaneous use of Analgin with tricyclic antidepressants, non-narcotic painkillers, Allopurinol and contraception, leads to increased toxicity of Analgin.
- Simultaneous use of Analgin with drugs that reduce the ability of blood to clot, drugs containing adrenal hormones, hormonal contraceptives, Indomethacin, drugs containing ethanol or alcoholic drinks, leads to increased action of the latter.
For whom is Analgin especially dangerous?
The likelihood of developing severe hypersensitivity reactions is higher in patients with the following pathologies:
- hypersensitivity to NSAIDs (asthmatic or allergic reaction);
- bronchial asthma;
- ethanol intolerance;
- intolerance to benzoates (common preservatives).
The analgesic is given with caution to victims with multiple traumatic injuries fabrics. Close monitoring of hemodynamic characteristics is necessary if the patient is diagnosed with acute pathologies heart and blood vessels (in particular myocardial infarction) or arterial hypotension. High risk of complications drug therapy with this drug in people suffering from dehydration.
Important: if diagnosed " acute stomach", metamizole sodium, as well as other analgesics, should not be given in order to avoid “blurring” the symptoms.
There is no data on the likelihood of the formation of fetal malformations under the influence of Analgin. Due to a lack of information, women preparing to become mothers are strongly advised to refrain from using the drug in the early and early stages. later. Since metamizole sodium partially blocks the production of prostaglandins, there is a possibility of early closure of the ductus arteriosus in the unborn child.
Analgin's metabolic products are able to penetrate into mother's milk, therefore this medicine Women should not drink during lactation. IN as a last resort, you can feed the baby no earlier than 2 days after taking it.
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