Manufacturer: Biocad JSC
Registration number: No. RK-LS-5 No. 016800
Registration date: 26.04.2016 - 26.04.2021
Instructions
- Russian
Tradename
GENFERON® LIGHT
International nonproprietary name
Dosage form
Suppositories 125,000 IU, 250,000 IU for vaginal or rectal administration
Compound
One suppository contains
active substances:
Excipients: dextran 60,000, macrogol 1500, polysorbate 80, T2 emulsifier, sodium hydrogen citrate, citric acid, purified water, hard fat.
Description
Suppositories are white or white with a yellowish tint, cylindrical in shape with a pointed end, uniform in longitudinal section. An air rod or funnel-shaped depression is allowed on the cut.
Pharmacotherapeutic group
Immunomodulators. Immunostimulants
ATX code L03A
Pharmacological properties
Pharmacokinetics
When the drug is administered rectally, high bioavailability (more than 80%) of interferon is observed, and therefore both local and pronounced systemic immunomodulatory effects are achieved. When intra vaginal use due to the high concentration at the site of infection and fixation on the cells of the mucous membrane, a pronounced local antiviral, antiproliferative and antibacterial effect is achieved, while the systemic effect, due to the low absorption capacity of the vaginal mucosa, is insignificant.
The maximum concentration of interferon in the blood serum is achieved 5 hours after rectal or vaginal insertion drug. The main route of excretion of α-interferon is renal catabolism. The half-life is 12 hours, which necessitates the use of the drug 2 times a day.
Pharmacodynamics
GENFERON® LIGHT - combination drug, the effect of which is determined by the components included in its composition. Has local and systemic effects.
The composition of the drug GENFERON® LIGHT includes recombinant human interferon alpha-2b, produced by a strain of the bacterium Escherichia coli, into which methods genetic engineering human interferon alpha-2b gene was introduced.
Activation under the influence of interferon of leukocytes contained in all layers of the mucous membrane ensures their active participation in the elimination of pathological foci; in addition, due to the influence of interferon, production restoration is achieved secretory immunoglobulin A. Antibacterial effect mediated reactions immune system, enhanced by interferon.
Taurine promotes normalization metabolic processes and tissue regeneration, has membrane-stabilizing and immunomodulatory effects. Being a strong antioxidant, taurine directly interacts with reactive oxygen species, the excessive accumulation of which contributes to the development of pathological processes. Taurine helps maintain the biological activity of interferon, enhancing therapeutic effect use of the drug.
Indications for use
as a component complex therapy- for the treatment of acute respiratory viral infections and others infectious diseases bacterial and viral etiology in children
for the treatment of infectious and inflammatory diseases of the urogenital tract in children and women, including pregnant women, when prescribed and supervised by a doctor specific therapy
Directions for use and doses
The drug can be used in adults both vaginally and rectally:
in children - only rectally!
The method of administration, dosage and course duration depend on age, the specific clinical situation and are determined by the attending physician.
In adults and children over 7 years of age, GENFERON® LIGHT is used in a dosage of 250,000 IU. In children from birth to 7 years of age, it is safe to use the drug at a dosage of 125,000 IU of interferon alfa-2b per suppository. In women who are 13-40 weeks pregnant, the drug is used at a dosage of 250,000 IU of interferon alfa-2b per suppository.
Acute infectious and inflammatory diseases of the urogenital tract in children: 1 suppository rectally 2 times a day with a 12-hour interval for 10 days against the background of specific therapy prescribed and supervised by a doctor.
Infectious and inflammatory diseases of the urogenital tract in pregnant women: 1 suppository (250,000 IU) vaginally 2 times a day with a 12-hour interval for 10 days against the background of specific therapy prescribed and supervised by a doctor.
Infectious and inflammatory diseases of the urogenital tract in women: 1 suppository (250,000 IU) vaginally or rectally (depending on the nature of the disease) 2 times a day with a 12-hour interval for 10 days against the background of specific therapy prescribed and supervised by a doctor. For prolonged forms, 1 suppository 3 times a week, every other day, for 1-3 months.
Acute respiratory viral infections and others acute diseases viral nature in children: 1 suppository rectally 2 times a day with a 12-hour interval parallel to the main therapy for 5 days. If, after a 5-day treatment period, the symptoms of the disease do not decrease or become more pronounced, the patient should consult a doctor. By clinical indications It is possible to repeat the course of treatment after a 5-day interval.
Chronic infectious and inflammatory diseases of viral etiology in children: 1 suppository (250,000 IU) rectally 2 times a day at 12-hour intervals parallel to standard therapy for 10 days. Then for 1-3 months - 1 suppository rectally at night every other day.
Side effects
The drug is well tolerated by patients.
Very rare (incidence less than 1 in 10,000 cases)
- allergic reactions (single reports).
These phenomena are reversible and disappear within 72 hours after cessation of administration. Continuation of treatment is possible after consultation with a doctor.
To date, no severe or life-threatening side effects have been observed.
Contraindications
- individual intolerance to interferon and other substances included in the drug
Drug interactions
GENFERON® LIGHT is most effective as a component of complex therapy. When combined with antibacterial, fungicidal and antiviral drugs Mutual potentiation of action is observed, which makes it possible to achieve a high total therapeutic effect.
special instructions
Use with caution during exacerbation of allergic and autoimmune diseases.
Pregnancy and lactation
Clinical studies have proven the effectiveness and safety of using the drug GENFERON® LITE in women who are 13-40 weeks pregnant. The safety of the drug in the 1st trimester of pregnancy has not been studied.
There are no restrictions for use during lactation.
Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
The drug GENFERON® LIGHT does not affect the performance of potentially dangerous species activities requiring special attention and speed of reactions.
Overdose
No cases of overdose with GENFERON® LITE have been reported. In case of accidental one-time administration more suppositories than prescribed by the doctor, further administration should be suspended for 24 hours, after which treatment can be resumed according to the prescribed regimen.
Genferon is a combination drug that has immunomodulatory, antimicrobial and antiviral effects on the body. Doctors will advise you on how to administer it correctly.
Genferon suppositories - how to administer correctly?
Components of Genferon suppositories: taurine and anasthesin have anti-inflammatory, antioxidant, membrane and hepatoprotective, reparative, regenerative and anesthetic effects. Genferon is used for infectious and inflammatory diseases of the urogenital tract: chlamydia, genital herpes, prostatitis, balanitis, urethritis, adnexitis, bartholinitis, vulvovaginitis, cervicitis, cervical erosion, bacterial vaginosis, human papillomavirus infections, trichomoniasis, gardnerellosis and other similar diseases. It is important to know how to administer Genferon suppositories correctly in order to achieve maximum effect- Doctor's advice will help.
How to administer Genferon suppositories correctly - doctor’s advice
The method of application and the correct doses of Genferon suppositories depend on the severity of the disease and are prescribed by the attending physician. As a rule, for women with diseases of the urogenital tract, the doctor prescribes one suppository intravaginally twice a day. The course of treatment with Genferon suppositories is ten days. For prolonged forms of illness, it is recommended to administer Genferon correctly three times a week, every other day, in the amount of one suppository, for one to three months. For infectious and inflammatory diseases in men, Genferon is administered rectally. Doctors advise taking one suppository twice a day for ten days.
For pregnant women, the use of Genferon suppositories is allowed after the fifth month of pregnancy, but only if the benefit from treatment is significantly higher than the likelihood of occurrence harmful effects for the fruit.
Doctor's advice on correct insertion of suppositories
Like many medicines, Genferon has many side effects. Allergic reactions, sweating, joint pain, muscle pain and headaches, loss of appetite, fatigue, fever and chills are possible.
Genferon suppositories are contraindicated in case of intolerance to the components included in the drug, such as taurine, anesthesin, citric acid, sodium citrate, emulsifier T 2, Tween 80, polyethylene oxide 1500, dextran 60000, human recombinant interferon alpha-2.
In order not to bother yourself and your loved ones with questions about how to administer Genferon correctly, use contraception and do not have dubious intimate relationships. If you discover that your regular partner is sick, then treatment should be carried out together, and in this case it is also necessary to use protection.
Having found out after going to the pharmacy the cost of some prescribed medications, sometimes it’s time to contact a specialist again - a cardiologist or a psychologist - it all depends on your health and the amount. However, there are drugs that allow you to save money, since they contain several active ingredients at once, for example, Genferon suppositories. What can they save us from?
Triple blow to the disease
Genferon suppositories are prescribed for the treatment of urogenital diseases caused by viruses, fungi and bacteria. This medicine is prescribed for:
- toxoplasmosis;
- mycoplasma;
- any types of herpes;
- vaginal candidiasis;
- trichomoniasis;
- cervical erosion;
- adnexitis;
- weakened body defenses.
The drug is quite often prescribed as an immunostimulant, especially for children.
Suppositories are inserted into the anus or vagina 1-2 times, depending on the nature of the disease and the age of the patient. But before we dwell on the nuances of administration, let's figure out what the effect of the drug is based on. Genferon is a combination of three components:
- interferon (helps the blood develop its own immunity, and also provides additional interferons - substances formed in the blood during the reaction to viruses entering the body);
- taurine (strengthens interferon and also accelerates the regeneration of tissue cells, reducing the area of the inflammatory process);
- benzocaine (has analgesic properties).
Such wide range exposure allows you to effectively stimulate the activity of your own immunity.
Application nuances
Each suppository contains different quantities interferons - from 125 to 1000. Depending on the severity of the disease, a weaker or strong medicine. The dosage is determined solely by the doctor based on diagnostic procedures And general condition patient.
Treatment of women
If a woman has acute sexually transmitted infection, then, as a rule, 1 suppository is prescribed vaginally with a dosage of 250-500. Suppositories should be used 2 times a day. It is not recommended to delay the course of treatment for more than 10 days. Otherwise, the body may begin irreversible processes, associated with the “relaxation” of the immune system, which gets used to the fact that interferon protects it.
If a lady is being treated for a protracted infection, then the dosage regimen is slightly different: 1 suppository before bed, but for 1-3 months.
Treatment for men
Representatives of the stronger half of humanity are prescribed Genferon 500 to increase immunity, as well as for complex therapy of both sexual partners. Suppositories are used 2 times a day, after waking up and before going to bed. The course of treatment in this case is about 10 days.
Help for children
Doctors prescribe Genferon from the first days after birth. However, this is possible and advisable only if the baby has a really weakened immune system, which does not allow him to overcome the infection on his own. The drug is also used in cases of preparation for surgery.
For children, Genferon Light suppositories are usually prescribed with a dosage of 125 to minimize a possible allergic reaction.
Read also:
The intensity of treatment depends on the nature of the disease:
- chronic viruses require the administration of a suppository every other day before bedtime for 1-3 months;
- at viral infection The baby is given 2 suppositories: one in the morning, the other in the evening. The course of treatment is 5 days. If improvement occurs slowly, then after 5-7 days the treatment is repeated.
Genferon suppositories during pregnancy and lactation
For pregnant women, suppositories are prescribed only from the 2nd trimester. This is due to the fact that by activating the protective properties of the immune system, it is possible to provoke its rejection of the gestating fetus as a foreign organism. The dosage is calculated individually, depending on the severity of the infection. The drug is not prescribed during lactation.
Feedback
The instructions for the Genferon Light 125 suppositories for children say that this drug stimulates the body’s immune abilities after just 1-2 doses. This is also confirmed by reviews from mothers who, in this way, helped their babies recover faster from viral or infectious diseases. The leitmotif of reviews regarding the use of Genferon suppositories for children can be considered to be that young patients did not experience allergic reactions, but a noticeable therapeutic effect It was already on the 2nd day.
But women who use Genferon vaginally quite often complain of a burning sensation in the perineum, disturbances monthly cycle and heartburn. The last “side effect” was also noted by men. In general, the high efficiency of the drug allows you to “forgive” some minor shortcomings.
Genferon is an immunomodulatory medicine, the drug has antiviral effect on the body. I will consider in detail its instructions for use.
What is the composition and release form of Genferon?
Genferon is produced in yellowish-white suppositories; they are cylindrical in shape with a slightly pointed end. Active substance- human recombinant interferon alpha-2, in addition, taurine and benzocaine are present.
Excipients Genferon: solid fat, purified water, dextran 60,000, citric acid, polyethylene oxide 1500, sodium citrate, added Tween-80, as well as T2 emulsifier.
Suppositories of five pieces are packed in blister packs and placed in cardboard boxes, on which their expiration date is visible; it is two years from the date of release of the medicine. It is recommended to place the medication in cool conditions from two to eight degrees. You can purchase Genferon using a prescription form.
What is the effect of the drug Genferon?
The combined drug Genferon has a local immunomodulatory effect on the body, as well as a systemic one. Interferon alpha-2 also has antiviral and antimicrobial effects.
Under its influence, the activity of phagocytes, natural killer cells, and T-helper cells increases, and the differentiation of B-lymphocytes also improves. Interferon inhibits the replication of chlamydia, as well as the transcription of viruses.
Another active component of the drug Genferon is taurine, it has a membrane-protective, antioxidant effect, as well as an anti-inflammatory effect, in addition, it enhances regenerative processes in tissues.
Another component is benzocaine, it has a local anesthetic effect, reduces the permeability of cell membranes directly to sodium ions, and calcium is displaced from inner surface membranes, which leads to blocking of the nerve impulse. This substance prevents the occurrence of pain impulses.
The drug is absorbed through the mucous membrane when administered rectally or vaginally, after which it enters the tissues, in lymphatic system, as a result, the systemic effect of Genferon on the body is ensured. In addition, he provides local action.
What are the indications for use of the drug Genferon?
Rectal suppositories Genferon are prescribed as part of complex treatment with infectious and inflammatory processes occurring in the urogenital tract:
The remedy is indicated for genital herpes;
The drug is effective for chlamydia and ureaplasmosis;
Suppositories are prescribed for mycoplasmosis;
For trichomoniasis;
For vaginal candidiasis of a recurrent nature;
The drug is used for gardnerellosis and trichomoniasis;
With cervicitis and with;
For papillomavirus infection;
An effective remedy for bacterial vaginosis;
For cervical erosion;
The drug is prescribed for urethritis, vulvovaginitis, adnexitis and prostatitis.
In addition, the drug is effective in the presence of balanitis and balanoposthitis.
What are Genferon's contraindications for use?
The medicine Genferon is not used for hypersensitivity to its components.
What are Genferon's uses and dosage?
For diseases of the urogenital tract of an infectious-inflammatory nature, Genferon is used intravaginally, one suppository twice a day, the treatment period is ten days. For chronic processes, the drug is used every other day for one or three months.
For men with diseases of the urogenital tract, the drug is prescribed rectally, also one suppository twice a day, treatment lasts for at least ten days.
At joint use Genferon with antibiotics or other antimicrobial drugs intended for the treatment of urogenital pathologies, its effectiveness increases markedly.
When prescribing the drug simultaneously with vitamin E or ascorbic acid, the effect of interferon is enhanced. NSAIDs, as well as anticholinesterase drugs potentiate the effect of benzocaine.
Before using medicinal suppositories, it is first recommended to consult a doctor, and only then proceed therapeutic activities.
Overdose of Genferon
The instructions for use do not provide information about cases of overdose of Genferon, since there is none yet.
What are the side effects of Genferon?
The use of suppositories may lead to the development of some allergic reactions as skin itching and rash, these symptoms are reversible, they disappear without a trace three days after stopping the medication.
When using Genferon at a dosage of 10 million IU/day, the risk of developing such side effects: the patient develops headache, leukopenia, thrombocytopenia are noted, body temperature may increase, hyperhidrosis occurs, fatigue, myalgia cannot be ruled out, appetite decreases, and arthralgia develops.
special instructions
The drug should be used with caution in those patients with a history of autoimmune or allergic diseases, especially occurring in the acute stage.
What are Genferon's analogues?
Interferon alpha-2b + Taurine is an analogue; the product should be used after consultation with a doctor.
Conclusion
Treatment of urogenital infection should be carried out after examining the patient; if there are side effects, you should consult a specialist.
Genferon 1000000 is universal remedy, which simultaneously affects pathogenic microorganisms(bacteria, viruses) and helps speed up recovery through positive influence on the body - increases defenses. The drug is in the middle price category. The scope of application is wide, but there are practically no contraindications.
Other names and classification
On Latin: Genferon.
International nonproprietary name
Benzocaine + Interferon alpha-2b + Taurine.
Trade names
Genferon.
ATX
Composition and dosage forms
The drug is produced in the form of suppositories. Designed for rectal and vaginal administration. The solid contains several active ingredients, due to which a complex effect on the body and high level effectiveness in treatment:
- recombinant human interferon alpha-2a at a concentration of 1,000,000 IU;
- benzocaine or anesthesin (55 mg);
- taurine (10 g).
The suppositories have a cylindrical shape with a pointed end for ease of insertion into the genital tract through the vulva and into the anus. Additionally, the drug contains other components that do not exhibit immunomodulatory and antiviral activity:
- dextran 60000;
- hard fat;
- macrogol 1500;
- polysorbate 80;
- citric acid;
- sodium hydrogen citrate;
- emulsifier T2;
- purified water.
Candles can be purchased in packs of 10 pcs.
Pharmacological group
Immunomodulatory agents, interferons.
pharmachologic effect
The drug can be used in complex therapy and as an independent remedy, which depends on the degree of damage to the body, the state of the immune system, and the presence of other diseases.
Characterized by systemic action. Activation of biochemical processes under the influence of basic substances occurs only with regular use of suppositories over a given period. Candles are intended for local application and can be prescribed for the treatment of men and women.
Each of the active components acts according to different principles. Thus, recombinant human interferon alpha-2a exhibits the following properties:
- anti-inflammatory;
- immunomodulatory;
- antibacterial.
Increased defenses are ensured by enhancing the function of T-helpers, the body's natural killer cells and phagocytes. At the same time, there is a development of the process of changing the function of cells, their size, shape and ability to manifest metabolic activity in the process of differentiation. As a result, the immune system is stimulated, which triggers natural reactions to pathogenic particles that contribute to the development of the pathological condition.
In addition, there is a restoration of the process of production of immunoglobulin A. The body more effectively recognizes infected cells. Thanks to this, negative manifestations are eliminated faster and the patient’s condition improves. At viral diseases The mechanism of action of the drug is based on increasing the activity of intracellular enzymes, the key function of which is to block the process of synthesis of harmful microorganisms.
The drug works on the same principle against bacteria and cells that have been changed as a result of a developing tumor. The main function of Genferon is to maintain the immune system. Under influence negative factors defenses are weakened, the pathological condition continues to develop. In this case, there is no way for the body to overcome the disease on its own.
For this reason, it is advisable to use aids, which trigger a number of biochemical processes. When the body’s condition returns to normal, the intensity of the symptoms decreases, the course of treatment is stopped, because immunity has increased, and there is no longer a need for additional stimulants.
Another active component (taurine) represents a group of compounds with metabolic properties. Under its influence, a number of biochemical processes are normalized, thanks to which blood microcirculation and normal delivery speed are restored useful substances into cells. Due to this, there is also a slight increase in protective forces. Additionally, taurine exhibits regenerating properties, which accelerates tissue restoration.
Benzocaine (anesthesin) represents a group of local anesthetics. Under its influence the level of pain. The desired result is achieved thanks to the following processes: cell walls become less permeable under the influence of benzocaine, calcium ions are more actively removed from the receptors. At the same time, nerve impulses are blocked (do not reach the goal), and the process of their conduction is disrupted. Additionally, it is noted that nerve impulses do not arise at the endings of sensory nerves.
Despite the administration of the drug rectally, not only a local, but also a systemic effect is noted. This is because this remedy characterized by high bioavailability (80%).
The vaginal method of delivery of active components allows you to eliminate symptoms only locally, since the substances are poorly absorbed by the mucous membranes of the vagina.
The maximum level of activity of the drug is reached no earlier than 5 hours after using the suppository. The main components, in particular alpha-2a interferon, are removed from the body with the participation of the kidneys. You should know that the half-life of this substance is 12 hours; at the end of it, the drug stops working. It is recommended to use candles 2 times a day.
Indications for use of Genferon 1000000 IU
The drug is prescribed in the following cases:
- urogenital diseases accompanied inflammatory process, as well as pathological conditions of viral or bacterial etiology: vaginal candidiasis, trichomoniasis, gardnerellosis, chronic recurrent cystitis, genital herpes, human papillomavirus infection, ureaplasmosis, mycoplasmosis, erosive processes in the structure of the cervical epithelium, prostatitis, etc.;
- bronchitis in the acute phase.
Method of use and dosage of Genferon 1000000 IU
At different pathological conditions The principle of therapy is different:
- diseases of the urogenital tract in women: permissible single doses vary from 250,000 to 1,000,000 IU; a more precise amount is determined individually, taking into account the degree of severity pathological process; suppositories are inserted into the anus or vagina 2 times a day (morning and night); the duration of treatment is 10 days;
- therapy for men with diseases of the urogenital tract is carried out according to the same scheme, but the dose of interferon should be 500,000 or 1,000,000 IU;
- treatment of bronchitis: 1 suppository (1,000,000 IU) twice a day; course of therapy - 5 days.
special instructions
To prevent the spread of infections of the urogenital tract, you should stop for a while. sex life, and also consider the issue of simultaneous treatment of the sexual partner.
Suppositories are allowed to be administered vaginally and during menstruation.
The drug has no effect on vital function important organs and systems, which means there are no contraindications to driving while using suppositories.
During pregnancy and breastfeeding
Genferon is approved for use, but in a smaller dosage - 250,000 IU. During the 1st trimester, the drug cannot be used, because there is not enough information about the degree of its effect on the fetus. Genferon in moderate doses is prescribed up to 40 weeks of pregnancy.
The product is also allowed to be used during lactation.
In childhood
The drug can be used, but in limited quantities. Thus, children under 7 years of age are prescribed no more than 125,000 IU. For patients aged 7-18 years, a dose of 250,000 IU may be recommended.
Side effects of Genferon 1000000 IU
Negative reactions develop infrequently. Women may experience a burning sensation in the vagina. This symptom disappears without the need for auxiliary therapy after 3 days. The doctor decides whether to continue the course of treatment.
The use of interferon of any type provokes the development of the following symptoms:
- temperature increase;
- general weakness;
- chills;
- loss of appetite;
- headache;
- discomfort in the muscles;
- joint pain;
- disruption of the hematopoietic system (thrombocytopenia).
Contraindications
The advantages of the product include the minimum number of restrictions on use. Only an individual negative reaction to any active substance as part of Genferon. In this case, the course of therapy should be stopped.
Additionally, they note the need for careful use of the drug when various diseases autoimmune nature, allergies.
Overdose
When using suppositories, increasing the dose does not provoke the occurrence of negative reactions. However, in cases of administration of an amount of the drug exceeding 10,000,000 IU, side effects increase. If the intensity of symptoms increases, a break in treatment for 1 day may be recommended.
Interoperability and Compatibility
Genferon is rarely used as an independent measure. More often it is prescribed simultaneously with other drugs that affect the cause of the disease (antimicrobial drugs) or eliminate the symptoms of the pathological condition.
Benzocaine in Genferon helps reduce the level of activity of drugs from the sulfonamide group. This substance exhibits higher efficiency under the influence analgesics non-narcotic and anticholinesterase drugs.
With alcohol
The combination of alcohol-containing drinks and Genferon is not recommended for use. This is due to the fact that alcohol helps to reduce the immunomodulatory activity of the drug.
Manufacturer
BIOCAD (Russia).
Conditions for dispensing from pharmacies
The product represents a group of prescription drugs.
Price
The average cost is 810 rubles.
Conditions and shelf life
The air temperature varies within +2...+8°С. For this reason, suppositories must be stored in the refrigerator. Children should not have access to the medicine.
Genferon retains its properties for 2 years from the date of release.
Analogs
Instead of the drug in question, other drugs containing recombinant human interferon are prescribed different types(Interferon, Viferon). Additionally, products based on other components can be used. However, according to the principle of action, such drugs are always weaker than interferon-containing analogues.
Concentration medicinal substance may vary. For this reason, when choosing an analogue, you should take into account this factor so that you do not have to recalculate the amount of the product or revise the entire treatment regimen.
In order to ensure a complex effect on the body, multicomponent substitutes should be considered. In this case, the drug will be able to provide antiviral, antibacterial, immunomodulatory, and in addition, analgesic activity. Otherwise, you will need to prescribe drugs with such properties separately.
Loading...